methyl methanesulfonate has been researched along with methylnitronitrosoguanidine in 164 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 112 (68.29) | 18.7374 |
| 1990's | 37 (22.56) | 18.2507 |
| 2000's | 12 (7.32) | 29.6817 |
| 2010's | 2 (1.22) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Rosin, MP; Stich, HF | 1 |
| Sandberg, AA; Shiraishi, Y | 1 |
| Fahrig, R | 1 |
| Amsbaugh, SC; Dipaolo, JA; Popescu, NC | 3 |
| Frei, JV; Lawley, PD | 1 |
| Jacoby, GA; Kung, AH; Lee, BT; Lehrbach, P | 1 |
| Boling, ME; Kimball, RF; Perdue, SW | 1 |
| Lemontt, JF | 1 |
| Pekhov, AP; Reshetnikova, VN | 1 |
| Chernin, LS; Goldfarb, DM; Ovadis, MI | 1 |
| Katsuki, M; Otsuji, N; Sekiguchi, M; Yamamoto, Y | 1 |
| Cairns, J; Defais, M; Jeggo, P; Samson, L; Schendel, PF | 1 |
| Griffin, DE; Hill, WE | 1 |
| Huang, SL | 1 |
| Bases, R; Elequin, F; Kadish, A; Liebeskind, D; Mendez, F; Rubinstein, A; Wittner, D | 1 |
| Hsie, AW; O'Neill, JP; Schenley, RL | 1 |
| Barker, CJ; Rackham, BD | 1 |
| Chang, C; Lee, CG | 1 |
| Heidelberger, C; Peterson, AR; Peterson, H | 1 |
| Casto, BC; Dipaolo, JA; Janosko, N; Pieczynski, WJ | 1 |
| Narui, K; Sadaie, Y | 1 |
| Dipalo, JA; Myhr, BC | 1 |
| Ellenberger, J; McGregor, D; Merker, HJ; Mohn, G | 1 |
| Henderson, E; Scudiero, D; Strauss, B | 1 |
| Lawley, PD | 1 |
| Henderson, E; Norin, A; Scudiero, D; Strauss, B | 1 |
| Masek, F; Sedliaková, M | 1 |
| Bilbin, M; Czeczot, H; Tudek, B | 1 |
| Inoue, H; Ishii, C; Nakamura, K | 1 |
| Erickson, LC | 1 |
| Allalunis-Turner, J; Day, RS; Miyakoshi, J; Scudiero, DA | 1 |
| Berger, NA; Berger, SJ; Chatterjee, S; Cheng, MF | 1 |
| Hajec, LI; Volkert, MR | 1 |
| Berger, ML; Graupner, PR; Sainsbury, M; Shertzer, HG | 1 |
| Berger, ML; Sainsbury, M; Shertzer, HG | 1 |
| Ben-Hur, E; Elkind, MM; Shibuya, ML; Wells, RL | 1 |
| Friederich, U; Grüter, A; Würgler, FE | 1 |
| Hartshorn, JN; Robison, SH; Scicchitano, DA | 1 |
| Fornace, AJ; Hollander, MC; Papathanasiou, MA; Yarosh, DB | 1 |
| Karwan, A; Klein, F; Wintersberger, U | 1 |
| Pattee, PA; Tam, JE | 1 |
| Inoue, H; Ishii, C | 1 |
| Volkert, MR | 1 |
| Faustman, EM; Gage, D; Kirby, Z; Varnum, M | 1 |
| Bartlett, JD; Bradley, WG; Hartshorn, JN; Jones, SK; Magin, GK; Nee, LE; Pendlebury, WW; Polinsky, RJ; Sweet, L; Tandan, R | 1 |
| Pueyo, C; Roldán-Arjona, T; Ruiz-Rubio, M | 1 |
| Goad, DL; Rebeck, GW; Samson, L; Smith, CM | 1 |
| Sagher, D; Schwartz, JL; Strauss, B; Turkula, T | 1 |
| Fornace, AJ; Hollander, MC; Wilson, SH; Zmudzka, B | 1 |
| Bartlett, JD; Bradley, WG; Jones, SK; Nee, LE; Polinsky, RJ; Robison, SH; Sweet, L | 1 |
| Schwartz, JL | 2 |
| Brent, TP | 1 |
| Chen, XR; Dai, YF; Yu, YN | 1 |
| Amacher, DE; Dunn, EM | 1 |
| Beard, KC; Nguyen, DC; Volkert, MR | 1 |
| Aeschbacher, HU | 1 |
| Dalbadie-McFarland, G; Davis, EF; Foster, PL; Richards, JH; Schultz, SC | 1 |
| Stuy, JH; Walter, RB | 1 |
| Karwan, A; Wintersberger, U | 1 |
| Babich, MA; Day, RS | 1 |
| Sakagishi, Y; Sakamoto, Y; Sonoda, M; Uyemura, K; Yano, K | 1 |
| Berger, ML; Reitman, FA; Shertzer, HG | 1 |
| Hall, J; Karran, P; Kataoka, H; Stephenson, C | 1 |
| Klein, CB; Molina, M; Rossman, TG | 1 |
| Evensen, G; Kaasen, I; Seeberg, E | 1 |
| Hall, J; Karran, P; Kataoka, H | 1 |
| Goth-Goldstein, R; Hughes, M | 1 |
| Kaina, B | 2 |
| Ibric, LL; Peterson, AR; Peterson, H | 1 |
| Hiwasa, T; Sakiyama, S | 1 |
| Stratford, IJ; Walling, JM | 1 |
| Laval, F | 1 |
| Frosina, G; Laval, F | 1 |
| Anuszewska, E; Koziorowska, J | 1 |
| Day, RS; DiPaolo, JA; Doniger, J | 1 |
| Christensen, RB; Lawrence, CW; Nisson, PE | 1 |
| Schechtman, LM | 1 |
| Abbondandolo, A; Frosina, G | 1 |
| Aune, T; Deilhaug, T; Haugen, A; Krokan, H; Myrnes, B | 1 |
| Iwanaga, S; Kondo, H; Miyata, T; Nakabeppu, Y; Sekiguchi, M | 1 |
| Jeggo, PA; Kemp, LM | 1 |
| Fukamachi, H | 1 |
| Henderson, EE; Ribecky, R | 1 |
| Andrae, U; Schwarz, LR | 1 |
| Benigni, R; Calcagnile, A; Dogliotti, E; Falcone, E | 1 |
| Das, SK | 1 |
| Cleaver, JE; Morgan, WF | 1 |
| Fronko, G; Henderson, EE | 1 |
| Kataoka, H; Sekiguchi, M; Yamamoto, Y | 1 |
| Sargentini, NJ; Smith, KC | 1 |
| Aihara, M; Miyaki, M; Ono, T; Suzuki, K | 1 |
| Grisham, JW; Smith, GJ | 2 |
| Behlau, I; Rein, RP; Shanabruch, WG; Walker, GC | 1 |
| Balganesh, M; Setlow, JK | 1 |
| Mahna, SK | 1 |
| Huang, SS; Pontzer, NJ; Shaikh, B | 1 |
| DiPaolo, JA; Popescu, NC | 1 |
| Laval, F; Laval, J | 1 |
| Fujimura, S; Ohkubo, M; Sakiyama, S | 1 |
| Evans, HH; Glazier, KG; Horng, MF; Weber, MC | 1 |
| Boorstein, RJ; Pardee, AB | 1 |
| Barfknecht, TR; Little, JB | 3 |
| Kikuchi, H; Watanabe, M | 1 |
| Moseley, BE; Tempest, PR | 1 |
| Fazio, M; Tong, C; Williams, GM | 1 |
| Peterson, AR; Peterson, H | 1 |
| Defais, M; Schendel, PF | 1 |
| Sklar, R; Strauss, B | 1 |
| Hannan, MA; Nasim, A; Nestmann, ER | 1 |
| Casperson, C; Huang, SL; Huang, SM; Waters, MD | 1 |
| Hieda-Shiomi, N; Sato, K; Shiomi, T | 1 |
| Das, SK; Lau, CC; Pardee, AB | 1 |
| Igel, HJ; Kropko, ML; Lake, RS; McLachlan, S; Pezzutti, MR; Shoemaker, RH | 1 |
| Becker, Y; Shiloh, Y | 1 |
| Irwin, J; Strauss, B | 1 |
| Balwierz, PS; Molinary, SV; Oshiro, Y | 1 |
| Busbee, DL; Jacobson, MK; Mitchell, VR; Rankin, PW | 1 |
| Deering, RA; Podgorski, G | 1 |
| Peterson, AR | 1 |
| Dave, P; Fasullo, M; Rothstein, R | 1 |
| Ito, T; Maki, H; Nakamura, T; Sekiguchi, M | 1 |
| Auer, B; Fritz, G; Kaina, B | 1 |
| Hayashi, M; Honma, M; Kikuno, T; Mizusawa, H; Ogura, S; Sofuni, T | 1 |
| Rawson, TY; Showalter, SD; Srivastava, DK; Wilson, SH | 1 |
| Samson, L; Xiao, W | 1 |
| Sledziewska-Gójska, E | 1 |
| Angel, P; Herr, I; Herrlich, P; Steffen, A; van Dam, H; Wilhelm, D | 1 |
| Chung, HK; Hong, SH; Joe, CO; Lee, JK; Park, EJ; Park, SD | 1 |
| Baumgartner, E; Einhaus, M; Holz, O; Krause, T; Meissner, R; Rüdiger, HW | 1 |
| Kolasa, IK; Kusmierek, JT; Mroczkowska, MM | 1 |
| Denizeau, F; Moffatt, P; Plaa, GL | 1 |
| Dosch, J; Kaina, B | 1 |
| Haas, S; Kaina, B; Kappes, H | 1 |
| Angel, P; Bender, K; Knebel, A; Wilhelm, D | 1 |
| Casto, BC; Lee, H; Li, D; Milo, GE; Prior, T; Shuler, CF; Weghorst, CM | 1 |
| Bianchi, L; Prosperi, E; Savio, M; Stivala, LA; Vannini, V | 1 |
| Justus, T; Thomas, SM | 1 |
| Dinglay, S; Gold, B; Sedgwick, B | 1 |
| Berger, MS; Blank, A; Bobola, MS; Silber, JR; Tseng, SH | 1 |
| Collins, AR; Gábelová, A; Hlincíková, L; Horváthová, E; Mandal, TK; Slamenová, D | 1 |
| Kaina, B; Ochs, K; Sobol, RW; Wilson, SH | 1 |
| Andersen, JS; Baun, A; Nyholm, N | 1 |
| Brozmanová, J; Chovanec, M; Farkasová, E; Margison, GP; Vlasáková, D; Vlcková, V | 1 |
| Boiteux, S; Chevalier, C; Ielpi, L; Labigne, A; O'Rourke, EJ; Radicella, JP | 1 |
| Ballario, P; Fujimoto, N; Handa, N; Inoue, H; Ishii, C; Macino, G; Noguchi, Y; Sakuraba, Y | 1 |
| Adachi, N; Koyama, H; Matsuzaki, Y | 1 |
| Almeida, KH; Engelward, BP; Horton, JK; Joyce, DF; Kartalou, M; Prasad, R; Samson, LD; Sobol, RW; Wilson, SH | 1 |
| Caldwell, D; Kelley, MR; Rinne, M | 1 |
| Erixon, K; Goldman, AS; Helleday, T; Jenssen, D; Lundin, C; North, M; Walters, K | 1 |
| Christmann, M; Fabian, K; Kaina, B; Tomicic, MT | 1 |
| Engelward, BP; Marinus, MG; Nowosielska, A; Smith, SA | 1 |
| Pittman, DL; Wyatt, MD | 1 |
| Briegert, M; Kaina, B | 1 |
| Kaina, B; Nikolova, T; Staszewski, O | 1 |
| Horváthová, E; Kováciková, I; Navarová, J; Slamenová, D; Wsólová, L | 1 |
| Jatsenko, T; Kivisaar, M; Saumaa, S; Sidorenko, J | 1 |
| Kim, KQ; Marcinkiewicz, T; McHugh, EP; Thomas, EN; Zaher, HS | 1 |
8 review(s) available for methyl methanesulfonate and methylnitronitrosoguanidine
| Article | Year |
|---|---|
The nature of the alkylation lesion in mammalian cells.
Topics: Alkylating Agents; Binding Sites; Cell Line; DNA; DNA Repair; DNA Replication; HeLa Cells; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Structure-Activity Relationship | 1975 |
"Excision" of bases from DNA methylated by carcinogens in vivo and its possible significance in mutagenesis and carcinogenesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinogens; Dimethylnitrosamine; DNA; Escherichia coli; Liver; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Organ Specificity; Rats; Species Specificity | 1975 |
The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition.
Topics: Animals; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Rats; Streptozocin | 1991 |
BALB/c 3T3 cell transformation: protocols, problems and improvements.
Topics: Animals; Biotransformation; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Research Design | 1985 |
The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures.
Topics: Alkylating Agents; Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Haplorhini; Kidney; Liver; Mammals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Placenta; Rats | 1985 |
Predictive and mechanistic evaluation to toxic responses in mammalian cell culture systems.
Topics: Alkylating Agents; Animals; Cell Division; Cell Line; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Culture Techniques; Cytological Techniques; Dimethylnitrosamine; Flow Cytometry; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Toxicology | 1984 |
Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline.
Topics: Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Cell Line, Transformed; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Proto-Oncogene Proteins c-bcl-2 | 2005 |
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks.
Topics: Animals; DNA Breaks; DNA Methylation; DNA Repair; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine | 2006 |
156 other study(ies) available for methyl methanesulfonate and methylnitronitrosoguanidine
| Article | Year |
|---|---|
The inhibitory effect of cysteine on the mutagenic activities of several carcinogens.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Acrylamides; Aflatoxins; Carcinogens; Cysteine; Genetic Techniques; Histidine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Microsomes, Liver; Mutagens; Salmonella typhimurium; Semicarbazones | 1978 |
Effects of various chemical agents on sister chromatid exchanges, chromosome aberrations, and DNA repair in normal and abnormal human lymphoid cell lines.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Cell Survival; Chromosome Aberrations; Crossing Over, Genetic; DNA Repair; Ethyl Methanesulfonate; Humans; Leukemia, Experimental; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycins | 1979 |
Evidence that induction and suppression of mutations and recombinations by chemical mutagens in S. cerevisiae during mitosis are jointly correlated.
Topics: 4-Nitroquinoline-1-oxide; Acridine Orange; Chlorophenols; Dinitrofluorobenzene; Drug Interactions; Ethyl Methanesulfonate; Halogenated Diphenyl Ethers; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitosis; Mutagens; Mutation; Phenyl Ethers; Recombination, Genetic; Saccharomyces cerevisiae; Sodium Nitrite; Triethylenemelamine | 1979 |
The relevance of a caffeine post-treatment to SCE incidence induced in Chinese hamster cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; Cell Line; Chromosome Aberrations; Chromosomes; Cisplatin; Cricetinae; Crossing Over, Genetic; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Ultraviolet Rays; X-Rays | 1979 |
Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N' -nitro-N-nitrosoguanidine: lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at 0-6 of guanine.
Topics: Animals; Carcinogens; DNA; Female; Guanine; Lymphoma; Mesylates; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Nitrosoguanidines; Thymus Gland; Thymus Neoplasms | 1976 |
Plasmid modification of radiation and chemical-mutagen sensitivity in Pseudomonas aeruginosa.
Topics: DNA Polymerase I; DNA Repair; Drug Resistance, Microbial; Gamma Rays; Mesylates; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Pseudomonas aeruginosa; R Factors; Radiation, Ionizing; Recombination, Genetic; Ultraviolet Rays | 1977 |
Evidence that UV-inducible error-prone repair is absent in Haemophilus influenzae Rd, with a discussion of the relation to error-prone repair of alkylating-agent damage.
Topics: Alkylating Agents; DNA Repair; Ethyl Methanesulfonate; Haemophilus influenzae; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Nitrogen Mustard Compounds; Nitroso Compounds; Phenotype; Ultraviolet Rays; X-Rays | 1977 |
Mutagenesis of yeast by hydrazine: dependence upon post-treatment cell division.
Topics: Canavanine; Cell Division; Drug Resistance, Microbial; Ethyl Methanesulfonate; Genes; Hydrazines; Hydroxylamines; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Nitrous Acid; Saccharomyces cerevisiae; Ultraviolet Rays | 1977 |
[Test-strains of E. coli for detection of chemical mutagens].
Topics: Escherichia coli; Hydroxylamines; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Nitrous Acid; Proflavine | 1977 |
F plasmid genes involved in the production of recombination-stimulating factor, control of sensitivity to some injurious agents, and chromosome replication in Escherichia coli K-12 HfrC.
Topics: Chromosome Mapping; Chromosomes, Bacterial; DNA, Bacterial; Escherichia coli; Genotype; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Plasmids; Recombination, Genetic; Temperature; Ultraviolet Rays | 1978 |
Escherichia coli gene that controls sensitivity to alkylating agents.
Topics: Alkylating Agents; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Ethyl Methanesulfonate; Genes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycins; Mutation; Transduction, Genetic | 1978 |
Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents.
Topics: Alkylating Agents; DNA Repair; DNA, Bacterial; Escherichia coli; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation | 1978 |
In vitro breakage of plasmid DNA by mutagens and pesticides.
Topics: Aldrin; Chlordan; DDT; Dichlorvos; Dieldrin; DNA, Circular; Escherichia coli; Ethyl Methanesulfonate; Heptachlor; Malathion; Methyl Methanesulfonate; Methyl Parathion; Methylnitronitrosoguanidine; Mutagens; Pesticides; Plasmids; Toxaphene | 1978 |
The mutability of the minute loci and sex-linked recessive lethals in Drosophila melanogaster.
Topics: Animals; Crosses, Genetic; Drosophila melanogaster; Ethyl Methanesulfonate; Female; Gene Frequency; Genes, Lethal; Genes, Recessive; Genetic Linkage; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Nitrosomethylurethane; Sex Chromosomes | 1977 |
Mutagen-induced disturbances in the DNA of human lymphocytes detected by antinucleoside antibodies.
Topics: Alkylating Agents; Antibodies; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Nucleosides | 1979 |
Cytotoxicity and mutagenicity of alkylating agents in cultured mammalian cells (CHO/HGPRT system): mutagen treatment in the presence or absence of serum.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Female; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Nitrosourea Compounds; Ovary | 1979 |
The induction of sister-chromatid exchanges in cultured fish cells (Ameca splendens) by carcinogenic mutagens.
Topics: Animals; Bromodeoxyuridine; Carcinogens; Cell Line; Cricetinae; Crossing Over, Genetic; Ethyl Methanesulfonate; Fibroblasts; Fishes; Humans; Karyotyping; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Sister Chromatid Exchange | 1979 |
Direct study of alkylating agent--RNA interaction by 13C nuclear magnetic resonance spectroscopy.
Topics: Alkylating Agents; Binding Sites; Carcinogens; DNA; Magnetic Resonance Spectroscopy; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Structure-Activity Relationship; Sulfuric Acid Esters | 1978 |
Oncogenesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents.
Topics: Alkylating Agents; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA Repair; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens | 1979 |
Significance of treatment interval and DNA repair in the enhancement of viral transformation by chemical carcinogens and mutagens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetoxyacetylaminofluorene; Adenoviridae; Aflatoxins; Benzopyrenes; Caffeine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cytarabine; DNA Repair; DNA Replication; Methyl Methanesulfonate; Methylcholanthrene; Methylnitronitrosoguanidine; Mutagens; Oncogenic Viruses; Propiolactone | 1976 |
Repair deficiency, mutator activity, and thermal prophage inducibility in dna-8132 strains of Bacillus subtilis.
Topics: 4-Nitroquinoline-1-oxide; Bacillus subtilis; Bacteriophages; DNA Repair; DNA, Bacterial; Drug Resistance, Microbial; Gamma Rays; Genes; Lysogeny; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycins; Mutation; Radiation Effects; Temperature; Ultraviolet Rays; Virus Replication | 1976 |
Requirement for cell dispersion prior to selection of induced azaguanine-resistant colonies of Chinese hamster cells.
Topics: 2-Acetylaminofluorene; Animals; Azaguanine; Cell Line; Cells, Cultured; Cricetinae; Culture Media; Cytological Techniques; Drug Resistance; Hypoxanthine Phosphoribosyltransferase; In Vitro Techniques; Lung; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Probability; Selection, Genetic | 1975 |
Mutagenicity studies in microorganisms in vitro, with extracts of mammalian organs, and with the host-mediated-assay.
Topics: DNA Repair; Drug Interactions; Escherichia coli; Kupffer Cells; Liver; Methods; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Nitrosomethylurethane; Quinones | 1975 |
The measurement of chemically-induced DNA repair synthesis in human cells by BND-cellulose chromatography.
Topics: Benz(a)Anthracenes; Cell Line; Chromatography, DEAE-Cellulose; DNA; DNA Repair; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens | 1975 |
Inducible stable DNA replication in Escherichia coli uvr+ and uvr- cells, treated with genotoxic chemicals.
Topics: 4-Nitroquinoline-1-oxide; 4-Quinolones; Acrylates; Anti-Infective Agents; Chloramphenicol; DNA Replication; Escherichia coli; Furans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mitomycin; Mutagens; Nalidixic Acid; Nitro Compounds; Nitrofurans | 1992 |
Induction of aberrant crypts in the colons of rats by alkylating agents.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Wistar | 1992 |
A novel phenotype of an excision-repair mutant in Neurospora crassa: mutagen sensitivity of the mus-18 mutant is specific to UV.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Chromosome Mapping; DNA Damage; DNA Repair; DNA, Bacterial; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electrophoresis, Agar Gel; Epistasis, Genetic; Gamma Rays; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycin; Mitomycins; Mutation; Neurospora crassa; Phenotype; Ultraviolet Rays | 1991 |
The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylating agents.
Topics: Carmustine; Cell Line, Transformed; Cell Survival; DNA Repair; DNA, Viral; Fibroblasts; Glutathione; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Nitrosourea Compounds; Phenotype; RNA, Messenger; RNA, Viral; Simian virus 40 | 1991 |
Alkylating agent hypersensitivity in poly(adenosine diphosphate-ribose) polymerase deficient cell lines.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; DNA Repair; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Lethal Dose 50; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Poly(ADP-ribose) Polymerases; Sulfuric Acid Esters | 1991 |
Molecular analysis of the aidD6::Mu d1 (bla lac) fusion mutation of Escherichia coli K12.
Topics: Alkylation; Escherichia coli; Genetic Complementation Test; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Phenotype; Restriction Mapping; Species Specificity | 1991 |
Mechanisms of chemical mediated cytotoxicity and chemoprotection in isolated rat hepatocytes.
Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Erythrocyte Membrane; Hemolysis; In Vitro Techniques; Indoles; Lipid Peroxides; Liver; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Rats | 1991 |
Membrane stabilization as a fundamental event in the mechanism of chemoprotection against chemical intoxication.
Topics: Animals; Antioxidants; Cell Membrane; Cell Survival; In Vitro Techniques; Lipid Peroxidation; Liver; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Osmotic Fragility; Rats; Rats, Inbred Strains | 1991 |
Cellular NAD+ and ATP levels in alkylation-induced cytotoxicity enhanced by an inhibitor of poly(ADP-ribose) synthesis.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cell Survival; Cells, Cultured; Cricetinae; Fibroblasts; Intracellular Fluid; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; NAD; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors | 1990 |
Antimutagenic effects of mushrooms.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxin B1; Aflatoxins; Aminacrine; Basidiomycota; Benzo(a)pyrene; DNA Repair; Ethanol; Fluorenes; Hot Temperature; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutation; Nitrogen Mustard Compounds | 1990 |
Measurements of genomic and gene-specific DNA repair of alkylation damage in cultured human T-lymphocytes.
Topics: Alkylating Agents; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; DNA Repair; DNA Replication; Genes; Humans; Kinetics; Lymphocyte Activation; Methyl Methanesulfonate; Methylnitronitrosoguanidine; T-Lymphocyte Subsets; T-Lymphocytes | 1990 |
Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.
Topics: Cell Line; Gene Expression; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; RNA, Messenger; X-Rays | 1990 |
Pedigree analyses of yeast cells recovering from DNA damage allow assignment of lethal events to individual post-treatment generations.
Topics: DNA Damage; Ethyl Methanesulfonate; Genes, Fungal; Genes, Lethal; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Nitrous Acid; Probability; Saccharomyces cerevisiae | 1990 |
Characterization and genetic mapping of a mutation affecting apurinic endonuclease activity in Staphylococcus aureus.
Topics: 4-Nitroquinoline-1-oxide; Chromosome Mapping; Chromosomes, Bacterial; Deoxyribonuclease IV (Phage T4-Induced); DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Ethyl Methanesulfonate; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycin; Mitomycins; Mutation; Nitrous Acid; Recombination, Genetic; Staphylococcus aureus; Ultraviolet Rays | 1986 |
Epistasis, photoreactivation and mutagen sensitivity of DNA repair mutants upr-1 and mus-26 in Neurospora crassa.
Topics: 4-Nitroquinoline-1-oxide; Aminacrine; DNA Repair; Dose-Response Relationship, Radiation; Gamma Rays; Genotype; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycin; Mitomycins; Mutagens; Mutation; Neurospora; Neurospora crassa; Nitrogen Mustard Compounds; Ultraviolet Rays | 1989 |
Altered induction of the adaptive response to alkylation damage in Escherichia coli recF mutants.
Topics: Alkylation; Bacterial Proteins; beta-Galactosidase; Escherichia coli; Genes; Genes, Bacterial; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Operon | 1989 |
In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: structure-activity patterns.
Topics: Alkylating Agents; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethyl Methanesulfonate; Ethylnitrosourea; Female; In Vitro Techniques; Maternal-Fetal Exchange; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Pregnancy; Rats; Rats, Inbred Strains | 1989 |
DNA repair deficiency for alkylation damage in cells from Alzheimer's disease patients.
Topics: Alkylating Agents; Alzheimer Disease; DNA Damage; DNA Repair; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Skin | 1989 |
Simple method for precise determination of chemical lethality in the L-arabinose resistance test of Salmonella typhimurium.
Topics: 2-Naphthylamine; Arabinose; Biotransformation; Drug Resistance, Microbial; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Salmonella typhimurium | 1989 |
Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium.
Topics: Cysteine; DNA Repair; Escherichia coli; Guanine; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Salmonella typhimurium | 1989 |
The relationship between O6-alkylguanine alkyltransferase activity and sensitivity to alkylation-induced sister chromatid exchanges in human lymphoblastoid cell lines.
Topics: Alkylating Agents; Carmustine; Cell Line, Transformed; Humans; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange | 1989 |
Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; DNA Damage; DNA Polymerase I; Female; Gene Expression Regulation; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Ovary; RNA, Messenger; Ultraviolet Rays | 1989 |
Decreased DNA repair in familial Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Cell Line, Transformed; Cell Transformation, Viral; DNA; DNA Repair; Female; Humans; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Middle Aged | 1989 |
Monofunctional alkylating agent-induced S-phase-dependent DNA damage.
Topics: Alkylating Agents; Animals; Bromodeoxyuridine; Cell Line; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Replication; Female; Interphase; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Ovary | 1989 |
Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA.
Topics: Alkylating Agents; DNA; Dose-Response Relationship, Drug; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Sulfuric Acid Esters | 1986 |
The cell-cycle dependent and the DNA-damaging agent-induced changes of cellular NAD content and their significance.
Topics: 4-Nitroquinoline-1-oxide; Benzamides; Cell Cycle; Cell Line; DNA Damage; DNA Replication; Humans; Interphase; Methyl Methanesulfonate; Methylnitronitrosoguanidine; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases | 1987 |
Mutagenesis at the ouabain-resistance locus of 3.7.2C L5178Y cells by chromosomal mutagens.
Topics: Animals; Chromosomes; Drug Resistance; Epichlorohydrin; Hydrocarbons, Iodinated; Leukemia L5178; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mutagenicity Tests; Mutagens; Ouabain; Sodium-Potassium-Exchanging ATPase | 1985 |
Escherichia coli gene induction by alkylation treatment.
Topics: Alkylation; beta-Galactosidase; Enzyme Induction; Escherichia coli; Galactosidases; Genes; Genes, Bacterial; Genotype; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Plasmids; Species Specificity; Transduction, Genetic | 1986 |
Rates of micronuclei induction in different mouse strains.
Topics: Animals; Cell Nucleus; Dose-Response Relationship, Drug; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Mitomycin; Mitomycins; Mutagenicity Tests; Species Specificity | 1986 |
Creation of a test plasmid for detecting G-C-to-T-A transversions by changing serine to arginine in the active site of beta-lactamase.
Topics: Aflatoxins; Amino Acid Sequence; Arginine; beta-Lactamases; Binding Sites; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Plasmids; Serine; Ultraviolet Rays | 1987 |
Isolation and characterization of a UV-sensitive mutator (mutB1) mutant of Haemophilus influenzae.
Topics: DNA, Bacterial; Haemophilus influenzae; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Ultraviolet Rays | 1988 |
Retardation of cell cycle progression in yeast cells recovering from DNA damage: a study at the single cell level.
Topics: Cell Cycle; Cell Nucleus; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Nitrous Acid; Saccharomyces cerevisiae | 1987 |
Potentiation of cytotoxicity by 3-aminobenzamide in DNA repair-deficient human tumor cell lines following exposure to methylating agents or anti-neoplastic drugs.
Topics: Antineoplastic Agents; Benzamides; Busulfan; Cell Line; Cell Survival; DNA Repair; Drug Synergism; Ethylnitrosourea; Humans; Kinetics; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1988 |
Reactions of ultimate carcinogens with cell membranes: importance of carbamoylation of phosphatidylethanolamine by the carcinogens.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Chickens; Erythrocyte Membrane; Kidney; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Lipids; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Phosphatidylethanolamines; Rats | 1988 |
Toxicity of methylating agents in isolated hepatocytes.
Topics: Animals; Cell Survival; Dimethylnitrosamine; Lipid Peroxides; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Promethazine; Rats; Rats, Inbred Strains | 1988 |
The contribution of O6-methylguanine and methylphosphotriesters to the cytotoxicity of alkylating agents in mammalian cells.
Topics: Alkylating Agents; Animals; Cell Line; Cloning, Molecular; Cricetinae; DNA Damage; DNA Repair; Drug Resistance; Guanine; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Organophosphates; Organophosphorus Compounds; Structure-Activity Relationship; Transfection | 1988 |
Comutagens in E. coli and Chinese hamster cells with special attention to arsenite.
Topics: Animals; Arsenic; Arsenites; Cell Line; Cricetinae; Cricetulus; Drug Interactions; Drug Resistance; Escherichia coli; Lung; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Ouabain; Ultraviolet Rays | 1986 |
Amplified expression of the tag+ and alkA+ genes in Escherichia coli: identification of gene products and effects on alkylation resistance.
Topics: Alkylation; Cloning, Molecular; DNA Glycosylases; DNA Repair; DNA, Bacterial; Escherichia coli; Genes; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; N-Glycosyl Hydrolases; Plasmids | 1986 |
Complementation of sensitivity to alkylating agents in Escherichia coli and Chinese hamster ovary cells by expression of a cloned bacterial DNA repair gene.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Glycosylases; DNA Repair; Escherichia coli; Female; Genes, Bacterial; Genetic Complementation Test; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; N-Glycosyl Hydrolases; Ovary; Plasmids | 1986 |
Cell killing by various monofunctional alkylating agents in Chinese hamster ovary cells.
Topics: Alkylating Agents; Animals; Caffeine; Cell Cycle; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary | 1987 |
Correction of alkylation hypersensitivity of CHO-W27-1 cells by transfection with human DNA.
Topics: Alkylation; Animals; Cricetinae; Cricetulus; DNA; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1987 |
Poly(ADP-ribose) synthesis and inhibition of DNA synthesis in Chinese hamster cells treated with methylating agents and thymidine.
Topics: Animals; Cricetinae; Cricetulus; Depression, Chemical; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Fibroblasts; Lung; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; NAD; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Thymidine | 1986 |
Increase in the synthesis of a Mr 32,000 protein in BALB/c 3T3 cells after treatment with tumor promoters, chemical carcinogens, metal salts, and heat shock.
Topics: 3,3'-Diaminobenzidine; Animals; Arsenic; Arsenites; Ascorbic Acid; Carcinogens; Deoxycholic Acid; Diglycerides; Diterpenes; Gene Expression Regulation; Hot Temperature; Isoelectric Point; Metals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Molecular Weight; Protease Inhibitors; Sodium Compounds; Terpenes | 1986 |
Chemosensitization by monofunctional alkylating agents.
Topics: Animals; Antineoplastic Agents; Cell Line; Cisplatin; Cricetinae; Drug Synergism; Ethyl Methanesulfonate; In Vitro Techniques; Melphalan; Methyl Methanesulfonate; Methylnitronitrosoguanidine | 1986 |
Adaptive response to alkylating agents in mammalian cells.
Topics: Adaptation, Physiological; Alkylating Agents; Animals; Cell Survival; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1986 |
The O6-methylguanine-DNA-methyltransferase activity of rat hepatoma cells is increased after a single exposure to alkylating agents.
Topics: Alkylating Agents; Animals; Cell Line; Ethyl Methanesulfonate; Liver Neoplasms, Experimental; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1987 |
DNA repair and sensitivity of mouse embryo fibroblasts to methyl methanesulphonate and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Cell Division; Cells, Cultured; DNA Repair; Embryo, Mammalian; Fibroblasts; Hydroxyurea; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Mice, Inbred DBA | 1985 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
UV and chemical mutagenesis in rev7 mutants of yeast.
Topics: Alleles; Diploidy; Ethyl Methanesulfonate; Genes, Fungal; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Saccharomyces cerevisiae; Ultraviolet Rays | 1985 |
Persistence of sister chromatid exchanges and in vitro morphological transformation of Syrian hamster fetal cells by chemical and physical carcinogens.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; DNA; Fetus; Mesocricetus; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycin; Mitomycins; Sister Chromatid Exchange | 1985 |
Potentiation of alkylation-induced sister chromatid exchange frequency by 3-aminobenzamide is mediated by intracellular loss of NAD+.
Topics: Adenosine Triphosphate; Alkylation; Animals; Benzamides; Cell Line; Cell Membrane Permeability; Clone Cells; Cricetinae; Cricetulus; Drug Synergism; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; NAD; Ovary; Sister Chromatid Exchange | 1986 |
Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung.
Topics: Animals; Carcinogens; Cells, Cultured; DNA Repair; Ethylnitrosourea; Lung; Macrophages; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Pulmonary Alveoli; Rabbits | 1985 |
Structure and expression of the alkA gene of Escherichia coli involved in adaptive response to alkylating agents.
Topics: Alkylating Agents; Amino Acid Sequence; Bacterial Proteins; Base Sequence; DNA Glycosylases; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Methyl Methanesulfonate; Methylnitronitrosoguanidine; N-Glycosyl Hydrolases; Nucleic Acid Conformation; Plasmids | 1984 |
X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents.
Topics: Animals; Bleomycin; Cell Line; Cricetinae; Cricetulus; DNA Repair; Ethyl Methanesulfonate; Female; Methods; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Ovary; Ultraviolet Rays; X-Rays | 1983 |
Acceleration of epithelial keratinization by carcinogens in fetal rat forestomach in organ culture.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetoxyacetylaminofluorene; Animals; Carcinogens; Epithelium; Gastric Mucosa; Keratins; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Organ Culture Techniques; Rats; Rats, Inbred F344; Stomach; Tretinoin | 1984 |
Transformation of human leukocytes with Epstein-Barr virus after cellular exposure to chemical or physical mutagens.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; Herpesvirus 4, Human; Humans; Leukocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Ultraviolet Rays; X-Rays | 1980 |
Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Diazonium Compounds; Dimethylnitrosamine; DNA; DNA Repair; Epoxy Compounds; Liver; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Rats; Rats, Inbred Strains; Uracil | 1981 |
DNA repair studies on diallate, triallate and sulfallate in human cell cultures.
Topics: Cells, Cultured; Ditiocarb; DNA Repair; Embryo, Mammalian; Epithelium; Herbicides; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Thiocarbamates; Triallate | 1982 |
Multiplicity reactivation of alkylating agent damaged herpes simplex virus (type I) in human cells.
Topics: Animals; Cell Line; Cells, Cultured; Chlorocebus aethiops; Fibroblasts; Humans; Kidney; Male; Mechlorethamine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Simplexvirus; Skin | 1982 |
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts.
Topics: Benzamides; Cells, Cultured; DNA Repair; DNA, Single-Stranded; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerases; Time Factors; Ultraviolet Rays; X-Rays | 1983 |
Studies on chemical carcinogen enhancement of Epstein-Barr virus induced transformation of human neonatal and adult peripheral blood lymphocytes.
Topics: Adult; Autoradiography; Carcinogens; Cell Line; Cell Transformation, Viral; Cells, Cultured; Densitometry; DNA; DNA, Viral; Fetal Blood; Genes, Viral; Herpesvirus 4, Human; Humans; Infant, Newborn; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Nucleic Acid Hybridization | 1984 |
A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate.
Topics: Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation | 1983 |
Characterization of an Escherichia coli mutant (radB101) sensitive to gamma and uv radiation, and methyl methanesulfonate.
Topics: Chromosomes, Bacterial; DNA Repair; Escherichia coli; Gamma Rays; Genotype; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Ultraviolet Rays | 1983 |
Misincorporation in DNA synthesis after modification of template or polymerase by MNNG, MMS and UV radiation.
Topics: DNA; DNA Polymerase I; Escherichia coli; In Vitro Techniques; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Mutation; Polydeoxyribonucleotides; Ultraviolet Rays | 1983 |
Mutagenesis, by methylating and ethylating agents, in mutH, mutL, mutS, and uvrD mutants of Salmonella typhimurium LT2.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; DNA Repair; Ethyl Methanesulfonate; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Models, Genetic; Mutagens; Mutation; Recombination, Genetic; Salmonella typhimurium; Ultraviolet Rays | 1983 |
Prophage induction in Haemophilus influenzae and its relationship to mutation by chemical and physical agents.
Topics: Bacteriophages; Ethyl Methanesulfonate; Haemophilus influenzae; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycin; Mitomycins; Mutagens; Mutation; Ultraviolet Rays; Virus Activation | 1984 |
Transfection assay test system: assay of four chemical mutagens.
Topics: Bacillus subtilis; Bacteriophages; DNA, Viral; Ethyl Methanesulfonate; Hydroxylamine; Hydroxylamines; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Transfection | 1984 |
Urinary excretion of methylated purines and 1-methyl-nicotinamide following administration of methylating carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenine; Alkylating Agents; Animals; Carcinogens; Dimethylhydrazines; Dimethylnitrosamine; Guanine; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Niacinamide; Rats | 1980 |
Quantitative comparison between SCE and transformation frequencies induced by chemical carcinogens in Syrian hamster cells.
Topics: Acetoxyacetylaminofluorene; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cisplatin; Cricetinae; Embryo, Mammalian; Mesocricetus; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Sister Chromatid Exchange | 1984 |
Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.
Topics: Acclimatization; Alkylating Agents; Animals; Cell Line; Cell Survival; Drug Resistance; Kinetics; Liver Neoplasms, Experimental; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Rats | 1984 |
Cross-resistance studies with V79 Chinese hamster cells adapted to the mutagenic or clastogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Thioguanine; Ultraviolet Rays | 1983 |
Cytotoxicity of monofunctional alkylating agents. Methyl methanesulfonate and methyl-N'-nitro-N-nitrosoguanidine have different mechanisms of toxicity for 10T1/2 cells.
Topics: Animals; Cell Cycle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mutagens; Mutation; Structure-Activity Relationship | 1983 |
Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Alkylating Agents; Animals; Chromatography, Thin Layer; Enzyme Induction; Humans; Liver; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Nicotinamide N-Methyltransferase; Rats; Rats, Inbred Strains | 1983 |
Isolation and characterization of BHK cells sensitive to ionizing radiation and alkylating agents.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Drug; Drug Tolerance; Ethyl Methanesulfonate; Kidney; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Radiation Tolerance | 1984 |
Factors modifying 3-aminobenzamide cytotoxicity in normal and repair-deficient human fibroblasts.
Topics: Benzamides; Caffeine; Cell Cycle; Cell Division; Cell Survival; DNA Repair; Fibroblasts; Humans; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Poly Adenosine Diphosphate Ribose; Time Factors | 1984 |
Abnormal sensitivity of skin fibroblasts from familial polyposis patients to DNA alkylating agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Cell Survival; DNA; Ethyl Methanesulfonate; Fibroblasts; Humans; Intestinal Polyps; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Skin | 1982 |
Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Ataxia Telangiectasia; Cell Line; Cell Survival; Ethyl Methanesulfonate; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Reference Values; Skin | 1982 |
Preferential modification of the inverted repeat DNA of tetrahymena by N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Benzopyrenes; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Repetitive Sequences, Nucleic Acid; Tetrahymena pyriformis | 1982 |
Survival of hereditary retinoblastoma human skin fibroblasts after treatment with DNA-damaging chemicals.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Cell Survival; Cells, Cultured; Ethyl Methanesulfonate; Eye Neoplasms; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Retinoblastoma; Skin | 1982 |
Defective excision repair in a mutant of Micrococcus radiodurans hypermutable by some monofunctional alkylating agents.
Topics: DNA Repair; Drug Resistance, Microbial; Ethyl Methanesulfonate; Genes, Lethal; Hydroxylamines; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Micrococcus; Mitomycins; Mutagens; Mutation; Nitrous Acid | 1980 |
Cell cycle-specific mutagenesis at the hypoxanthine phosphoribosyltransferase locus in adult rat liver epithelial cells.
Topics: Cell Cycle; Cell Line; DNA Replication; Epithelium; Hypoxanthine Phosphoribosyltransferase; Liver; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitosis; Mutagens | 1980 |
Differences in temporal aspects of mutagenesis and cytotoxicity in Chinese hamster cells treated with methylating agents and thymidine.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; DNA Replication; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Mutation; Thymidine | 1982 |
The role of umuC gene product in mutagenesis by simple alkylating agents.
Topics: Alkylating Agents; DNA Repair; DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Ultraviolet Rays | 1980 |
Role of the uvrE gene product and of inducible O6-methylguanine removal in the induction of mutations by N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli.
Topics: Chloramphenicol; DNA Repair; DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Ethyl Methanesulfonate; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Protein Biosynthesis; Ultraviolet Rays | 1980 |
Pure and mosaic clones--a reflection of differences in mechanisms of mutagenesis by different agents in Saccharomyces cerevisiae.
Topics: DNA Repair; DNA Replication; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mosaicism; Mutation; Nitrous Acid; Saccharomyces cerevisiae | 1981 |
Induction of 6-thioguanine resistance in synchronized human fibroblast cells treated with methyl methanesulfonate, N-acetoxy-2-acetylaminofluorene and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Acetoxyacetylaminofluorene; Cell Cycle; Cell Line; Cytological Techniques; Dose-Response Relationship, Drug; Drug Resistance; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Skin; Thioguanine | 1981 |
A novel mutant of mouse lymphoma cells sensitive to alkylating agents and caffeine.
Topics: Alkylating Agents; Animals; Caffeine; Cell Survival; Ethyl Methanesulfonate; Leukemia L5178; Leukemia, Experimental; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mitomycins; Mutagenicity Tests; Mutagens; Mutation; Ultraviolet Rays | 1982 |
Abolition by cycloheximide of caffeine-enhanced lethality of alkylating agents in hamster cells.
Topics: Alkylating Agents; Animals; Caffeine; Cell Line; Cell Survival; Cricetinae; Cycloheximide; Drug Antagonism; Drug Synergism; Kidney; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine | 1982 |
Relationship of carcinogen-induced sister chromatid exchange and neoplastic cell transformation.
Topics: Acetoxyacetylaminofluorene; Animals; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; In Vitro Techniques; Mesocricetus; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Neoplasms, Radiation-Induced; Sister Chromatid Exchange | 1981 |
Chemical carcinogen induction of DNA-repair synthesis in human peripheral blood monocytes.
Topics: 2-Acetylaminofluorene; Aflatoxins; Benzopyrenes; Carcinogens; Cells, Cultured; Dimethylnitrosamine; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycins; Monocytes; Mutagens | 1980 |
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.
Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; DNA; DNA Repair; Female; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1981 |
Use of hydroxyurea in the measurement of DNA repair by the BND cellulose method.
Topics: Acetoxyacetylaminofluorene; Cell Line; Chromatography, DEAE-Cellulose; DNA; DNA Repair; Humans; Hydroxyurea; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens | 1980 |
Morphological transformation of C3H/10T1/2 CL8 cells by alkylating agents.
Topics: Alkylating Agents; Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical; Hydrocarbons, Iodinated; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Propiolactone; Thiophenes | 1981 |
Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes.
Topics: Carcinogens; DNA; DNA Repair; Humans; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; NAD | 1980 |
Quantitation of induced mutation in Dictyostelium discoideum: characterization and use of a methanol-resistance mutation assay.
Topics: Dictyostelium; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Microbial; Gamma Rays; Methanol; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Mutation; Ultraviolet Rays | 1980 |
DNA synthesis, mutagenesis, DNA damage, and cytotoxicity in cultured mammalian cells treated with alkylating agents.
Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA Repair; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mutation | 1980 |
DNA-damaging agents stimulate the formation of directed reciprocal translocations in Saccharomyces cerevisiae.
Topics: 4-Nitroquinoline-1-oxide; DNA Damage; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitosis; Mutagens; Ploidies; Recombination, Genetic; Saccharomyces cerevisiae; Sister Chromatid Exchange; Translocation, Genetic; Ultraviolet Rays | 1994 |
Roles of transcription and repair in alkylation mutagenesis.
Topics: Alkylation; Base Sequence; DNA Modification Methylases; DNA Mutational Analysis; DNA Repair; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutagenesis; Point Mutation; Ribosomal Protein S9; Ribosomal Proteins; Transcription, Genetic | 1994 |
Effect of transfection of human poly(ADP-ribose)polymerase in Chinese hamster cells on mutagen resistance.
Topics: Animals; Antimutagenic Agents; Blotting, Western; Cell Survival; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerases; Transfection | 1994 |
DNA fingerprint analysis in chemically mutagenized Chinese hamster lung cells.
Topics: 2-Acetylaminofluorene; Animals; Cell Line; Cricetinae; Cricetulus; Cyclophosphamide; DNA Fingerprinting; DNA Probes; DNA, Satellite; Furylfuramide; Lung; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycin; Mutagenesis; Mutagens | 1995 |
Phorbol ester abrogates up-regulation of DNA polymerase beta by DNA-alkylating agents in Chinese hamster ovary cells.
Topics: Alkylating Agents; Amino Acid Sequence; Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; DNA Damage; DNA Polymerase I; DNA Repair; Drug Antagonism; Epitope Mapping; Immunoblotting; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Molecular Sequence Data; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Up-Regulation | 1995 |
In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.
Topics: Alkylation; Deoxyribonuclease IV (Phage T4-Induced); DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Fungal; Endodeoxyribonucleases; Gene Expression; Genes, Fungal; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae | 1993 |
The level of GC-->AT transitions induced by MMS is not affected by the adaptive response in Escherichia coli K12.
Topics: Deoxyribonuclease I; DNA Repair; Escherichia coli; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Mutagenesis; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Suppression, Genetic | 1993 |
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.
Topics: Activating Transcription Factor 2; Base Sequence; Cell Differentiation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; DNA Damage; Gene Expression Regulation; Humans; MAP Kinase Kinase 4; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitogen-Activated Protein Kinase Kinases; Models, Genetic; Molecular Sequence Data; Phorbol Esters; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-jun; Signal Transduction; Structure-Activity Relationship; Threonine; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Ultraviolet Rays | 1995 |
Isolation of UV-inducible transcripts from Schizosaccharomyces pombe.
Topics: Amino Acid Sequence; Base Sequence; DNA Damage; DNA, Complementary; DNA, Fungal; Dose-Response Relationship, Radiation; Fungal Proteins; Glycoproteins; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Molecular Sequence Data; RNA, Messenger; Schizosaccharomyces; Sequence Analysis, DNA; Ultraviolet Rays | 1994 |
A novel technique for the detection of DNA single-strand breaks in human white blood cells and its combination with the unscheduled DNA synthesis assay.
Topics: Chromosome Aberrations; DNA Damage; DNA Mutational Analysis; DNA Repair; DNA, Single-Stranded; Environmental Monitoring; Humans; Leukocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Monocytes | 1993 |
Chloroacetaldehyde-induced mutagenesis in Escherichia coli: specificity of mutations and modulation by induction of the adaptive response to alkylating agents.
Topics: Acetaldehyde; Alkylating Agents; Carcinogens; DNA Damage; DNA Glycosylases; DNA Mutational Analysis; DNA Repair; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenesis; N-Glycosyl Hydrolases; Vinyl Chloride | 1993 |
Rat hepatocytes with elevated metallothionein expression are resistant to N-methyl-N'-nitro-N-nitrosoguanidine cytotoxicity.
Topics: Animals; Antineoplastic Agents, Alkylating; Cadmium; Cell Survival; Chromatography, Affinity; Copper; Glutathione; Lethal Dose 50; Liver; Male; Metallothionein; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Rats; Rats, Sprague-Dawley; Zinc | 1996 |
Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal
Topics: Alkylating Agents; Animals; Cell Death; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glycoproteins; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombination, Genetic; RNA, Messenger; Transcription Factor AP-1; Transfection; Ultraviolet Rays | 1996 |
A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs.
Topics: 4-Nitroquinoline-1-oxide; Animals; Animals, Newborn; Antineoplastic Agents; Benzo(a)pyrene; Cell Survival; Cells, Cultured; DNA Replication; Fibroblasts; Genes, fos; Melphalan; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Mice; Mice, Knockout; O(6)-Methylguanine-DNA Methyltransferase; S Phase; Time Factors | 1997 |
The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents.
Topics: Acetylcysteine; Alkylating Agents; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Ethylnitrosourea; Genes, jun; Glutamate-Cysteine Ligase; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerase Inhibitors; Receptors, Cell Surface; Reducing Agents; Signal Transduction; Ultraviolet Rays | 1997 |
Ineffectiveness of the presence of H-ras/p53 combination of mutations in squamous cell carcinoma cells to induce a conversion of a nontumorigenic to a tumorigenic phenotype.
Topics: Animals; Autoradiography; Blotting, Northern; Carcinoma, Squamous Cell; DNA, Complementary; Gene Expression Regulation, Neoplastic; Genes, p53; Genes, ras; Humans; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Nude; Mutation; Phenotype; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1997 |
Involvement of the proliferating cell nuclear antigen (PCNA) in DNA repair induced by alkylating agents and oxidative damage in human fibroblasts.
Topics: Alkylating Agents; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Repair; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Oxidative Stress; Proliferating Cell Nuclear Antigen | 1998 |
Construction of a umuC'-luxAB plasmid for the detection of mutagenic DNA repair via luminescence.
Topics: Artificial Gene Fusion; Bacterial Proteins; DNA Repair; DNA-Directed DNA Polymerase; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Genes, Reporter; Kinetics; Luminescent Measurements; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Plasmids; SOS Response, Genetics; Ultraviolet Rays; Vibrio | 1998 |
Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA.
Topics: Adenine; Apurinic Acid; Bacterial Proteins; Bacteriophage lambda; Binding Sites; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Damage; DNA Repair; DNA, Bacterial; DNA, Viral; Escherichia coli; Escherichia coli Proteins; Indicators and Reagents; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mixed Function Oxygenases; Mutagens; Mutation; Netropsin; Polynucleotides; Sulfuric Acid Esters; Virus Replication | 1998 |
Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Guanine; Humans; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Temozolomide; Tumor Cells, Cultured | 1996 |
The nature and origin of DNA single-strand breaks determined with the comet assay.
Topics: Animals; Antioxidants; Cricetinae; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Humans; Hydrogen Peroxide; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Vitamin E | 1998 |
Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.
Topics: Alkylating Agents; Animals; Apoptosis; Chromosome Aberrations; DNA Damage; DNA Polymerase beta; DNA Repair; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Knockout; Necrosis | 1999 |
Correcting for toxic inhibition in quantification of genotoxic response in the umuC test.
Topics: 4-Nitroquinoline-1-oxide; Antineoplastic Agents, Alkylating; Biomass; False Positive Reactions; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Sodium Azide; Water Pollutants | 1999 |
Effect of stable integration of the Escherichia coli ada gene on the sensitivity of Saccharomyces cerevisiae to the toxic and mutagenic effects of alkylating agents.
Topics: Alkylating Agents; Bacterial Proteins; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Transcription Factors | 2000 |
A novel 3-methyladenine DNA glycosylase from Helicobacter pylori defines a new class within the endonuclease III family of base excision repair glycosylases.
Topics: Amino Acid Motifs; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Blotting, Western; Chromatography, High Pressure Liquid; Deoxyribonuclease (Pyrimidine Dimer); DNA Adducts; DNA Glycosylases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endodeoxyribonucleases; Enzyme Induction; Escherichia coli Proteins; Helicobacter pylori; Lysine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutagenesis; N-Glycosyl Hydrolases; Open Reading Frames; Plasmids; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Substrate Specificity; Transcription, Genetic | 2000 |
Characterization of the Neurospora crassa mus-25 mutant: the gene encodes a protein which is homologous to the Saccharomyces cerevisiae Rad54 protein.
Topics: Alkylating Agents; Amino Acid Sequence; Cloning, Molecular; DNA Helicases; DNA Repair Enzymes; Epistasis, Genetic; Fungal Proteins; Gene Expression Regulation, Fungal; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutagens; Mutation; Neurospora crassa; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Ultraviolet Rays | 2000 |
Vertebrate cells lacking FEN-1 endonuclease are viable but hypersensitive to methylating agents and H2O2.
Topics: Animals; Cell Division; Cell Survival; Chickens; DNA; Dose-Response Relationship, Drug; Etoposide; Exodeoxyribonuclease V; Exodeoxyribonucleases; Hydrogen Peroxide; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Molecular Sequence Data; Mutation; Sequence Analysis, DNA; Tumor Cells, Cultured; Ultraviolet Rays | 2002 |
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.
Topics: Alkylating Agents; Animals; Base Sequence; Cells, Cultured; DNA; DNA Glycosylases; DNA Methylation; DNA Polymerase beta; DNA Repair; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Knockout; Mutation; Phenotype; Recombination, Genetic; Tumor Suppressor Protein p53 | 2003 |
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Topics: Adenoviridae; Alkylating Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; Dacarbazine; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Genetic Therapy; Genetic Vectors; Humans; Hydroxylamines; Immunohistochemistry; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Oligonucleotides; Sensitivity and Specificity; Sulfuric Acid Esters; Temozolomide; Time Factors | 2004 |
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks.
Topics: Alkylating Agents; Animals; Cell Line; Cricetinae; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Electrophoresis, Gel, Pulsed-Field; Hot Temperature; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Recombination, Genetic; X-ray Repair Cross Complementing Protein 1; Yeasts | 2005 |
Homologous recombination prevents methylation-induced toxicity in Escherichia coli.
Topics: Adenosine Triphosphatases; Alkylating Agents; DNA Helicases; DNA Methylation; DNA Polymerase I; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutation; Recombination, Genetic | 2006 |
Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.
Topics: Alkylating Agents; Cell Survival; Cells, Cultured; Dacarbazine; Dendritic Cells; DNA Methylation; DNA Repair; Drug Hypersensitivity; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Monocytes; Mutagens; Temozolomide | 2007 |
Kinetics of gamma-H2AX focus formation upon treatment of cells with UV light and alkylating agents.
Topics: Alkylating Agents; Animals; CHO Cells; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Fluorescent Antibody Technique; Histones; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Phosphorylation; Time Factors; Ultraviolet Rays | 2008 |
Carboxymethyl chitin-glucan (CM-CG) protects human HepG2 and HeLa cells against oxidative DNA lesions and stimulates DNA repair of lesions induced by alkylating agents.
Topics: Alkylating Agents; Antioxidants; Aspergillus niger; Chitin; Comet Assay; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; Glucans; HeLa Cells; Hep G2 Cells; Humans; Hydrogen Peroxide; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Oxidative Stress | 2010 |
DNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putida.
Topics: Alkylation; Bacterial Proteins; DNA Adducts; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Directed DNA Polymerase; DNA, Bacterial; Drug Resistance, Bacterial; Genes, Reporter; Lac Operon; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens; Mutation; Phenotype; Promoter Regions, Genetic; Pseudomonas aeruginosa; Pseudomonas putida; Recombinant Fusion Proteins; Rifamycins; Species Specificity; Temperature | 2017 |
Alkylative damage of mRNA leads to ribosome stalling and rescue by
Topics: Alkylating Agents; Alkylation; Escherichia coli; Escherichia coli Proteins; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Protein Biosynthesis; Ribosomes; RNA, Bacterial; RNA, Messenger | 2020 |