methyl methanesulfonate has been researched along with hydroxyurea in 137 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (15.33) | 18.7374 |
| 1990's | 20 (14.60) | 18.2507 |
| 2000's | 65 (47.45) | 29.6817 |
| 2010's | 27 (19.71) | 24.3611 |
| 2020's | 4 (2.92) | 2.80 |
| Authors | Studies |
|---|---|
| Obermeier, J; Weinblum, D; Zahn, RK; Zollner, EJ | 1 |
| Ansley, CM; Craddock, VM; Henderson, AR | 1 |
| Banerjee, MR; Bodell, WJ | 1 |
| Clarkson, JM | 1 |
| Higgins, NP; Kato, K; Strauss, B | 1 |
| Karran, P; Norin, A; Scudiero, D; Strauss, B | 1 |
| Baranowska, H; Jachymczyk, WJ; Zaborowska, D; Zuk, J | 1 |
| Fargnoli, J; Fornace, AJ; Holbrook, NJ; Hollander, MC; Luethy, JD; Nebert, DW; Papathanasiou, M | 1 |
| Maemori, M; Matsuda, Y; Seki, N; Tobari, I | 1 |
| Kupiec, M; Simchen, G | 1 |
| Allison, DC; Bose, KK | 1 |
| Anuszewska, E; Koziorowska, J | 1 |
| Ockey, CH | 1 |
| Sakaguchi, K; Sono, A | 1 |
| Snyder, RD | 1 |
| Strauss, BS | 1 |
| Andrae, U | 1 |
| Bianchi, V; Levis, AG; Zantedeschi, A | 1 |
| Baral, E; Lambert, B; Lewensohn, R; Ringborg, U | 1 |
| Hwang, CG; Pitot, HC; Sattler, GL; Sirica, AE | 1 |
| Gupta, PK; Sirover, MA | 1 |
| Irwin, J; Strauss, B | 1 |
| Jan, KY; Lee-Chen, SF; Wang, MC; Wu, DR; Yu, CT | 1 |
| Araki, H; Leem, SH; Phongdara, A; Sugino, A | 1 |
| Fay, DS; Foiani, M; Marini, F; Stern, DF; Sun, Z | 1 |
| Fraschini, R; Longhese, MP; Lucchini, G; Plevani, P | 1 |
| Björklund, S; Filatov, D; Johansson, E; Thelander, L | 1 |
| Andrews, B; Ho, Y; Hoekstra, M; Kobayashi, R; Mason, S | 1 |
| Ciesla, Z; Fikus, MU; Mieczkowski, PA | 1 |
| Warr, N; Watts, FZ; Willson, J; Wilson, S | 1 |
| Fraschini, R; Longhese, MP; Lucchini, G; Paciotti, V; Plevani, P; Zaccarini, R | 1 |
| Ando, S; Matsumoto, K; Shimomura, T; Sugimoto, K | 1 |
| Casagrande, R; Chabes, A; Huffaker, TC; Thelander, L; Tian, XC; Wang, PJ | 1 |
| Gurr, JR; Jan, KY; Lai, HT; Lynn, S | 1 |
| Arroyo, MP; Wang, TS | 2 |
| Fay, DS; Hsiao, J; Stern, DF; Sun, Z | 1 |
| Johnstone, P; Kohler, S; Moses, RE; Olson, S; Reifsteck, C; Worland, P | 1 |
| Gilbert, CS; Green, CM; Lowndes, NF; Vialard, JE | 1 |
| Tavassoli, M; Watts, FZ; Wilson, S | 1 |
| Gaudet, P; Tsang, A | 1 |
| Henriques, JA; Pereira, VR; Saffi, J | 1 |
| Enomoto, T; Miyajima, A; Onoda, F; Seki, M | 1 |
| Enomoto, T; Kikuchi, Y; Miyajima, A; Odagiri, N; Ohno, Y; Ohta, K; Onoda, F; Seki, M; Shiratori, M | 1 |
| Ciesla, Z; Dajewski, W; Mieczkowski, P; Podlaska, A; Skoneczna, A; Sledziewska-Gójska, E | 1 |
| Beckwith, W; McAlear, MA | 1 |
| Foss, EJ | 1 |
| Enomoto, T; Miyajima, A; Ohno, Y; Onoda, F; Satoh, Y; Seki, M; Ui, A | 1 |
| Mankouri, HW; Morgan, A | 1 |
| D'Urso, G; Feng, W | 1 |
| Bennett, RJ; Wang, JC | 1 |
| Kunkel, TA; Pavlov, YI; Shcherbakova, PV | 1 |
| Chakraverty, RK; de La Torre Ruiz, MA; Grenon, M; Hickson, ID; Kearsey, JM; Lowndes, NF; Oakley, TJ | 1 |
| Baldo, V; Clerici, M; Longhese, MP; Lucchini, G; Paciotti, V; Romano, M | 1 |
| Carr, AM; Hartsuiker, E; Kohli, J; Vaessen, E | 1 |
| Craig, TJ; Mankouri, HW; Morgan, A | 1 |
| Hammet, A; Heierhorst, J; Pike, BL | 1 |
| Garber, PM; Rine, J | 1 |
| MacNeill, SA; Okayama, H; Ryu, GH; Seo, YS; Tanaka, H; Tanaka, K; Yuasa, Y | 1 |
| Campbell, SD; Radcliffe, CM; Silva, EA | 1 |
| Bellaoui, M; Boone, C; Brown, GW; Chang, M | 1 |
| Gasser, SM; Pasero, P; Shimada, K | 1 |
| Hijal, S; Larochelle, S; Masrouha, N; Suter, B; Yang, L | 1 |
| Campbell, JL; Imamura, O | 1 |
| Akamatsu, Y; Iwasaki, H; Lindsay, HD; Nakazaki, T; Shinagawa, H; Tomita, K; Ueno, M; Watanabe, K | 1 |
| Kuo, SR; Liu, JS; Melendy, T | 1 |
| Masukata, H; Matsuura, A; Nakagawa, T; Ono, Y; Tomita, K; Ueno, M; Uritani, M; Ushimaru, T | 1 |
| Diffley, JF; Jackson, D; Merrick, CJ | 1 |
| Chevalier, A; Dubacq, C; Mann, C | 1 |
| Garriott, ML; Hoffman, WP; Lee, C; Murphy, GP; Phelps, JB | 1 |
| Moriyama, A; Murakami, H; Nakanishi, M; Sugimoto, I; Tonami, Y | 1 |
| Denis, CL; Hammet, A; Heierhorst, J; Tenis, N; Traven, A | 1 |
| Ahmad, F; Stewart, E | 1 |
| Dalgaard, JZ; Huberman, JA; Karahan, N; Kumar, S; Pellny, TK; Sommariva, E | 1 |
| Duncker, BP; Prasad, AA; Ramer, MD; Scholz, RP; Varrin, AE | 1 |
| Alabert, C; Cordón-Preciado, V; Pasero, P; Tourrière, H; Versini, G | 1 |
| Krogh, BO; Lam, A; Llorente, B; Symington, LS | 1 |
| Masai, H; Matsumoto, S; Noguchi, E; Ogino, K; Russell, P | 1 |
| Hsu, JJ; Lawrence, NA; Loeb, LA; Preston, BD; Venkatesan, RN | 1 |
| Gottifredi, V; Podhajcer, O; Prives, C; Soria, G | 1 |
| Albuquerque, CP; Kats, ES; Kolodner, RD; Zhou, H | 1 |
| Holway, AH; Kim, SH; La Volpe, A; Michael, WM | 1 |
| Ciaramella, M; Ferrara, MC; Nadal, M; Napoli, A; Rossi, M; Valenti, A | 1 |
| Bueno, A; Cordón-Preciado, V; Ufano, S | 1 |
| Kaplan, Y; Kupiec, M | 1 |
| Lee, RT; Shi, QM; Wang, Y; Wang, YM; Zheng, XD | 1 |
| Franco, GR; Furtado, C; Macedo, AM; Machado, CR; Passos-Silva, DG; Pena, SD; Regis-da-Silva, CG | 1 |
| Horikoshi, M; Matsubara, K; Sano, N; Umehara, T | 1 |
| Han, J; Horazdovsky, B; Xu, RM; Zhang, K; Zhang, Z; Zhou, H | 1 |
| Abdu, U; Bakhrat, A; Butin-Israeli, V; Klovstad, M; Schüpbach, T | 1 |
| Hickson, ID; Mankouri, HW; Ngo, HP | 1 |
| Güerci, A; Liviac, D; Marcos, R | 1 |
| Bailis, JM; Forsburg, SL; Hunter, T; Luche, DD | 1 |
| Folch, A; Li, N; Monnat, RJ; Sidorova, JM | 1 |
| Cho, EJ; Kim, HJ; Park, HJ; Seol, JH; Yoo, JK | 1 |
| Boddy, MN; Campbell, D; Head, SR; Pebernard, S; Schaffer, L | 1 |
| Aparicio, OM; Bachant, J; Bhogal, NS; Gasparyan, HJ; Julius, JA; Nugent, CI; Petreaca, RC; Rex, AE; Small, VY; Warsi, TH; Xu, L | 1 |
| Brown, S; Lehmann, AR; Niimi, A | 1 |
| Alabert, C; Bianco, JN; Pasero, P | 1 |
| Janbandhu, VC; Kumar, V; Mukherji, A | 1 |
| Alby, K; Bennett, RJ | 1 |
| Bao, Q; Dröge, P; Goodman, SD; Henderson, D; Klonisch, T; Li, O; Peter, S; Sathiyanathan, P; Summer, H; Zhan, L | 1 |
| Bähler, J; Kupiec, M; Laor, D; López-Maury, L; Schonbrun, M; Weisman, R | 1 |
| Araki, H; Bando, M; Komata, M; Shirahige, K | 1 |
| Enserink, JM; Kats, ES; Kolodner, RD; Martinez, S | 1 |
| Deal, RB; Kandasamy, MK; McKinney, EC; Meagher, RB; Smith, AP | 1 |
| Bahn, YS; Floyd, A; Heitman, J; Jung, KW; Kim, GB; Ko, YJ; Maeng, S | 1 |
| Feng, J; Jiang, L; Li, J; Zhang, L; Zhao, J | 1 |
| Handa, H; Hayashi, Y; Horikoshi, M; Kawano, A; Noguchi, S; Yamaguchi, Y | 1 |
| Hannun, YA; Matmati, N; Mohanty, BK; Tripathi, K; Zheng, WJ | 1 |
| Bacal, J; Dorn, J; Kaiser, GS; Lee, EH; Lisby, M; Maddox, P; Pasero, P; St-Hilaire, E; Tsao, S; Verreault, A; Wurtele, H | 1 |
| Aslanian, A; de Bruin, RA; Guaderrama, M; Ideker, T; Kalashnikova, TI; Kuo, D; Smolka, MB; Thai, K; Travesa, A; Wittenberg, C; Yates, JR | 1 |
| Cai, M; Fang, Z; Zhang, J; Zhang, Y; Zhou, X | 1 |
| Chen, K; Gao, J; Hu, K; Li, W; Sang, J; Wang, H; Wang, Y; Wong, AH | 1 |
| Travesa, A; Wittenberg, C | 1 |
| Ohashi, E; Takeishi, Y; Tsurimoto, T; Ueda, S | 1 |
| Arumugam, P; Dalgaard, JZ; Eydmann, T; Koulintchenko, M; Vengrova, S | 1 |
| Duan, Y; Feng, J; Jiang, L; Zhao, Y | 1 |
| Eckert-Boulet, N; Eléouët, M; Gallina, I; Game, J; Germann, SM; Hamou, W; Lisby, M; Mathiasen, DP; Thodberg, S | 1 |
| Kupiec, M; Liefshitz, B; Shemesh, K; Singh, S | 1 |
| Addinall, SG; Dong, K; Lydall, D; Rutherford, JC | 1 |
| Han, WY; Huang, QH; Li, YZ; Liang, PJ; Ni, JF; She, QX; Shen, YL | 1 |
| Gao, H; Lustig, AJ; Moss, DL; Parke, C; Tatum, D | 1 |
| Bi, X; Khan, A; Li, C; Siler, J; Yu, Q | 1 |
| Aguilera, A; García-Rodríguez, N; Stuckey, R; Wellinger, RE | 1 |
| de Sena-Tomás, C; Holloman, WK; Kojic, M; Milisavljevic, M; Nikolic, DB; Pérez-Martín, J; Sutherland, JH | 1 |
| Fujimuro, M; Ito, A; Nakagawa, K; Nakata, S; Takeda, H; Watanabe, T | 1 |
| Bernstein, KA; Godin, SK; Herken, BW; Lee, AG; Mihalevic, MJ; Resnick, MA; Sobol, RW; Westmoreland, JW; Yu, Z; Zhang, Z | 1 |
| Bi, X; Kath, M; Siler, J; Wong, C; Xia, B | 1 |
| Fleck, O; Knapp, K; Villahermosa, D | 1 |
| Korbel, JO; Mardin, BR; Onishi-Seebacher, M; Segura-Wang, M; Stütz, AM | 1 |
| Jeong, SH; Kim, C; Kim, H; Kim, KP; Kim, KY; Kwack, K; Park, GH; Park, Y; Ro, M; Shin, HB; Yang, J | 1 |
| Choi, JE; Chung, WH; Heo, SH; Kim, MJ | 1 |
| Carvajal-Garcia, J; Gales, ER; Ramsden, DA; Sekelsky, J | 1 |
| Bravo Ruiz, G; Gow, NAR; Lorenz, A; Ross, ZK | 1 |
| Han, Q; Li, X; Liu, J; Wang, N; Wang, Y; Zhang, Y | 1 |
| Harris, C; Ray, S; Savas, J; Shanle, EK | 1 |
137 other study(ies) available for methyl methanesulfonate and hydroxyurea
| Article | Year |
|---|---|
Influence of UV irradiation, 4-nitroquinoline-u-oxide, methylmethanesulfonate, and bleomycin on the acitivity of an alkaline deoxyribonuclease from human lymphocytes.
Topics: 4-Nitroquinoline-1-oxide; Bleomycin; Caffeine; Deoxyribonucleases; Hydroxyurea; Lymphocytes; Mesylates; Methyl Methanesulfonate; Nitroquinolines; Radiation Effects; Ultraviolet Rays | 1976 |
Repair replication of DNA in the intact animal following treatment with dimethylnitrosamine and with methyl methanesulphonate, studied by fractionation of nuclei in a zonal centrifuge.
Topics: Animals; Cell Division; Cell Nucleus; Centrifugation, Zonal; Cycloheximide; Dimethylnitrosamine; Diploidy; DNA Repair; DNA Replication; Female; Hydroxyurea; Liver; Mesylates; Methyl Methanesulfonate; Mitosis; Nitrosamines; Polyploidy; Rats | 1976 |
DNA repair in normal and preneoplastic mammary tissues.
Topics: Animals; Bromodeoxyuridine; DNA Repair; DNA Replication; DNA, Neoplasm; Female; Hydroxyurea; In Vitro Techniques; Mammary Neoplasms, Experimental; Methyl Methanesulfonate; Mice; Mice, Inbred BALB C; Precancerous Conditions; Pregnancy; Thymidine | 1978 |
Enhancement of repair replication in mammalian cells by hydroxyurea.
Topics: Cell Line; DNA; DNA Repair; DNA Replication; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Nitrogen Mustard Compounds; Ultraviolet Rays | 1978 |
A model for replication repair in mammalian cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Centrifugation, Density Gradient; DNA Repair; DNA Replication; DNA, Neoplasm; Humans; Hydroxyurea; Methyl Methanesulfonate; Microscopy, Electron; Models, Biological; Molecular Weight; Xeroderma Pigmentosum | 1976 |
DNA excision-repair deficiency of human peripheral blood lymphocytes treated with chemical carcinogens.
Topics: Acetoxyacetylaminofluorene; Burkitt Lymphoma; Carcinogens; Cell Line; Cells, Cultured; Concanavalin A; DNA; DNA Repair; Hydroxyurea; Lymphocytes; Methyl Methanesulfonate; Time Factors | 1976 |
Role of the CDC8 gene in the repair of single strand breaks in DNA of the yeast Saccharomyces cerevisiae.
Topics: Centrifugation, Density Gradient; Cycloheximide; Diploidy; DNA Repair; DNA, Fungal; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Saccharomyces cerevisiae; Temperature | 1990 |
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media; DNA Damage; Female; Gene Expression; Growth Inhibitors; Humans; Hydroxyurea; Kinetics; Male; Methyl Methanesulfonate; Mice; Molecular Sequence Data; Poly A; Rats; RNA, Messenger; Ultraviolet Rays | 1989 |
Mechanism of chromosome aberration induction in the mouse egg fertilized with sperm recovered from postmeiotic germ cells treated with methyl methanesulfonate.
Topics: Animals; Benzamides; Caffeine; Chromosome Aberrations; Cytarabine; Female; Hydroxyurea; Male; Meiosis; Methyl Methanesulfonate; Mice; Mice, Inbred Strains; Mutagens; Ovum; Sister Chromatid Exchange; Spermatozoa; Zygote | 1989 |
Regulation of the RAD6 gene of Saccharomyces cerevisiae in the mitotic cell cycle and in meiosis.
Topics: Genes, Fungal; Genes, Regulator; Hydroxyurea; Kinetics; Meiosis; Methyl Methanesulfonate; Mitosis; RNA, Messenger; Saccharomyces cerevisiae; Transcription, Genetic; Ultraviolet Rays | 1986 |
Cytophotometric determination of unscheduled DNA synthesis.
Topics: Animals; Autoradiography; Cell Cycle; Cell Line; DNA; DNA Damage; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Humans; Hydroxyurea; Methyl Methanesulfonate; Mice | 1987 |
DNA repair and sensitivity of mouse embryo fibroblasts to methyl methanesulphonate and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Cell Division; Cells, Cultured; DNA Repair; Embryo, Mammalian; Fibroblasts; Hydroxyurea; Kinetics; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Mice, Inbred DBA | 1985 |
Fibre autoradiography of repair and replication in DNA from single cells: the effect of DNA synthesis inhibitors.
Topics: Autoradiography; Cell Cycle; Cells, Cultured; DNA Repair; DNA Replication; Fibroblasts; Floxuridine; HeLa Cells; Humans; Hydroxyurea; Leukocytes; Methyl Methanesulfonate; Ultraviolet Rays | 1982 |
Inhibition of protein synthesis antagonizes induction of sister-chromatid exchanges by exogenous agents.
Topics: Animals; Bromodeoxyuridine; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Crossing Over, Genetic; Cycloheximide; Ethyl Methanesulfonate; Floxuridine; Hydroxyurea; Methyl Methanesulfonate; Puromycin; Sister Chromatid Exchange | 1981 |
3-Aminobenzamide does not alter DNA repair in human fibroblasts through modulation of deoxynucleoside triphosphate pools.
Topics: Antineoplastic Agents; Benzamides; Cells, Cultured; Deoxyribonucleotides; DNA Repair; Fibroblasts; Humans; Hydroxamic Acids; Hydroxyurea; Male; Methyl Methanesulfonate; Skin | 1984 |
The interaction of u.v.- and methyl methanesulfonate-induced DNA repair synthesis: a role for poly(ADP-ribose)?
Topics: Cell Line; Cycloheximide; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Humans; Hydroxyurea; Kinetics; Leukemia, Lymphoid; Methyl Methanesulfonate; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Ultraviolet Rays | 1984 |
Evidence for the involvement of cytochrome P-450-dependent monooxygenase(s) in the formation of genotoxic metabolites from N-hydroxyurea.
Topics: Animals; Cell Differentiation; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Repair; DNA Replication; Enzyme Induction; Hydroxyurea; Liver Neoplasms, Experimental; Methyl Methanesulfonate; Mutagens; Oxygenases; Rats; Ultraviolet Rays | 1984 |
The scintillometric evaluation of DNA repair synthesis can be distorted by changes of thymidine pool radioactivity.
Topics: Animals; Autoradiography; Cell Line; Chromatography, Thin Layer; Cricetinae; DNA; DNA Repair; DNA Replication; Humans; Hydroxyurea; Methyl Methanesulfonate; Scintillation Counting; Thymidine; Ultraviolet Rays | 1983 |
DNA repair synthesis in subpopulations of human lymphocytes.
Topics: B-Lymphocytes; Cells, Cultured; DNA Repair; Humans; Hydroxyurea; Lymphocytes; Mechlorethamine; Methyl Methanesulfonate; T-Lymphocytes; Ultraviolet Rays | 1982 |
Use of primary cultures of adult rat hepatocytes on collagen gel-nylon mesh to evaluate carcinogen-induced unscheduled DNA synthesis.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Carcinogens; Cells, Cultured; Culture Media; Cytological Techniques; DNA; Hydroxyurea; Liver; Methyl Methanesulfonate; Microscopy, Phase-Contrast; Rats; Time Factors | 1980 |
Cell cycle regulation of DNA repair in normal and repair deficient human cells.
Topics: Acetoxyacetylaminofluorene; Cell Cycle; Cell Line; DNA Repair; DNA Replication; Fibroblasts; Humans; Hydroxyurea; Methyl Methanesulfonate; Ultraviolet Rays; Xeroderma Pigmentosum | 1981 |
Use of hydroxyurea in the measurement of DNA repair by the BND cellulose method.
Topics: Acetoxyacetylaminofluorene; Cell Line; Chromatography, DEAE-Cellulose; DNA; DNA Repair; Humans; Hydroxyurea; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mutagens | 1980 |
Nickel chloride inhibits the DNA repair of UV-treated but not methyl methanesulfonate-treated Chinese hamster ovary cells.
Topics: Animals; Carcinogens; Cell Survival; Centrifugation, Density Gradient; CHO Cells; Cricetinae; Cytarabine; DNA; DNA Repair; Hydroxyurea; Methyl Methanesulfonate; Nickel; Ultraviolet Rays | 1993 |
Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint.
Topics: Amino Acid Sequence; Cell Cycle; Cell Cycle Proteins; DNA Polymerase II; DNA-Binding Proteins; Dose-Response Relationship, Radiation; Flow Cytometry; Fungal Proteins; Gene Dosage; Genes, Fungal; Genes, Suppressor; Hydroxyurea; Methyl Methanesulfonate; Molecular Sequence Data; Mutation; Phenotype; Protein Binding; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid; Transglutaminases; Ultraviolet Rays | 1995 |
Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways.
Topics: Alkaline Phosphatase; Cell Cycle; Cell Cycle Proteins; Cell Division; Checkpoint Kinase 2; DNA Damage; DNA Replication; DNA, Fungal; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Hydroxyurea; Immunoblotting; Intracellular Signaling Peptides and Proteins; Methyl Methanesulfonate; Mutagenesis; Phosphorylation; Precipitin Tests; Protein Kinases; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Temperature | 1996 |
Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase.
Topics: Cell Cycle; Cell Cycle Proteins; DNA Damage; DNA Primase; DNA Replication; Dose-Response Relationship, Radiation; Genes, Fungal; Genetic Complementation Test; Genotype; Hydroxyurea; Methyl Methanesulfonate; Mitosis; Mutagenesis; Mutagens; RNA Nucleotidyltransferases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature; Ultraviolet Rays | 1996 |
Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light.
Topics: 3T3 Cells; Animals; DNA, Single-Stranded; Enzyme Induction; G1 Phase; Gene Expression Regulation, Enzymologic; Genes; Hydroxyurea; Methyl Methanesulfonate; Mice; Promoter Regions, Genetic; Resting Phase, Cell Cycle; Ribonucleotide Reductases; Ultraviolet Rays | 1996 |
Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae.
Topics: Casein Kinase I; Casein Kinases; Cell Cycle; DNA Damage; DNA Repair; Fungal Proteins; Gene Expression Regulation, Fungal; Hydroxyurea; Methyl Methanesulfonate; Phosphorylation; Protein Binding; Protein Kinases; RNA, Fungal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcription, Genetic | 1997 |
Characterization of a novel DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, which is a structural homolog of the RAD2 and RAD27 DNA repair genes.
Topics: Amino Acid Sequence; Base Sequence; Cell Cycle Proteins; Checkpoint Kinase 1; Checkpoint Kinase 2; Cloning, Molecular; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Fungal; Endodeoxyribonucleases; Exodeoxyribonucleases; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Humans; Hydroxyurea; Lac Operon; Meiosis; Methyl Methanesulfonate; Molecular Sequence Data; Mutagens; Mutation; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Restriction Mapping; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Ultraviolet Rays | 1997 |
Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.
Topics: Amino Acid Sequence; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Base Sequence; Cell Cycle Proteins; DNA Damage; DNA Replication; DNA, Fungal; Epistasis, Genetic; Fungal Proteins; Gene Deletion; Hydroxyurea; Methyl Methanesulfonate; Molecular Sequence Data; Mutation; Nuclear Proteins; Phenotype; Plasmids; Radiation Tolerance; Restriction Mapping; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 1997 |
The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.
Topics: Cell Cycle; Cell Cycle Proteins; Cloning, Molecular; DNA Damage; Epistasis, Genetic; Genes, Fungal; Glycoproteins; Hydroxyurea; Methyl Methanesulfonate; Mutagenesis; Mutagens; Periodicity; Phosphoproteins; Phosphorylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Suppression, Genetic; Ultraviolet Rays | 1997 |
Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway.
Topics: Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; DNA Replication; DNA-Binding Proteins; Fungal Proteins; G2 Phase; Gene Expression Regulation, Fungal; Genes, Fungal; Homeodomain Proteins; Hydroxyurea; Methyl Methanesulfonate; Minor Histocompatibility Antigens; Mutagens; Mutation; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Replication Protein C; Repressor Proteins; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Temperature; Transcriptional Activation; Ultraviolet Rays | 1997 |
Rnr4p, a novel ribonucleotide reductase small-subunit protein.
Topics: Amino Acid Sequence; Cloning, Molecular; Cold Temperature; Enzyme Inhibitors; Gene Dosage; Gene Expression Regulation, Fungal; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Molecular Sequence Data; Mutagens; Mutation; Phenotype; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; RNA, Fungal; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid | 1997 |
Arsenite retards DNA break rejoining by inhibiting DNA ligation.
Topics: Animals; Arsenites; Cell Survival; CHO Cells; Cricetinae; Cytarabine; DNA; DNA Damage; DNA Repair; Hydroxyurea; Kinetics; Methyl Methanesulfonate; Mutagenesis; Mutagens; Oligodeoxyribonucleotides; Poly A; Polydeoxyribonucleotides; Time Factors | 1997 |
Mutant PCNA alleles are associated with cdc phenotypes and sensitivity to DNA damage in fission yeast.
Topics: Alleles; Cell Cycle; DNA Damage; DNA Repair; DNA Replication; Gamma Rays; Genes, cdc; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Mutagenesis, Site-Directed; Phenotype; Proliferating Cell Nuclear Antigen; Saccharomyces; Temperature; Ultraviolet Rays | 1998 |
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.
Topics: Amino Acid Sequence; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; DNA Replication; Fungal Proteins; G2 Phase; Hydroxyurea; Methyl Methanesulfonate; Mitosis; Mutation; Oligopeptides; Peptides; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 1998 |
Fanconi anemia group A and D cell lines respond normally to inhibitors of cell cycle regulation.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Caffeine; Cell Cycle; Cells, Cultured; Central Nervous System Stimulants; Chromosome Breakage; Cross-Linking Reagents; DNA Adducts; Enzyme Inhibitors; Fanconi Anemia; Humans; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Mitomycin; Oxidants | 1997 |
The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.
Topics: Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; Fungal Proteins; G2 Phase; Gamma Rays; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Methyl Methanesulfonate; Mitosis; Mutagens; Mutation; Nocodazole; Phosphorylation; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ultraviolet Rays | 1998 |
Schizosaccharomyces pombe rad32 protein: a phosphoprotein with an essential phosphoesterase motif required for repair of DNA double strand breaks.
Topics: Adenosine Triphosphatases; Alleles; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Chromatography, Gel; DNA Damage; DNA Helicases; DNA Repair; Esterases; Exodeoxyribonucleases; Fungal Proteins; G2 Phase; Hydroxyurea; Iron; Meiosis; Methyl Methanesulfonate; Molecular Sequence Data; Molecular Weight; Mutagenesis; Phosphoproteins; Phosphorylation; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Spores, Fungal | 1998 |
Regulation of the ribonucleotide reductase small subunit gene by DNA-damaging agents in Dictyostelium discoideum.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cycloheximide; Dictyostelium; DNA Damage; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gene Expression Regulation, Enzymologic; Genes, Protozoan; Hydroxyurea; Kinetics; Methyl Methanesulfonate; Protein Biosynthesis; Response Elements; Ribonucleotide Reductases; RNA, Messenger; Sequence Deletion; Ultraviolet Rays; Up-Regulation | 1999 |
Schizosaccharomyces pombe replication and repair proteins: proliferating cell nuclear antigen (PCNA).
Topics: Cell Cycle; Cell Division; DNA Polymerase III; DNA Repair; DNA Replication; Fungal Proteins; Hydroxyurea; Methyl Methanesulfonate; Models, Molecular; Mutagenesis, Site-Directed; Mutagens; Phenotype; Proliferating Cell Nuclear Antigen; Protein Structure, Tertiary; Schizosaccharomyces; Temperature | 1999 |
Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae.
Topics: 4-Nitroquinoline-1-oxide; Cell Division; DNA Helicases; DNA Repair; Hydrogen Peroxide; Hydroxyurea; Mechlorethamine; Methyl Methanesulfonate; Mutagens; Mutation; Quinolones; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ultraviolet Rays | 2000 |
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.
Topics: Alleles; Bloom Syndrome; DNA Helicases; Dose-Response Relationship, Drug; Genetic Complementation Test; Hydroxyurea; Methyl Methanesulfonate; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Phenotype; Plasmids; Recombination, Genetic; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Sister Chromatid Exchange; Transfection; Werner Syndrome | 2000 |
Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions.
Topics: Adenosine Triphosphatases; Cell Cycle Proteins; DNA Helicases; DNA Repair; DNA Topoisomerases, Type I; DNA-Binding Proteins; Endodeoxyribonucleases; Enzyme Inhibitors; Exodeoxyribonucleases; Flow Cytometry; Fungal Proteins; Genotype; Hydroxyurea; Meiosis; Methyl Methanesulfonate; Mitosis; Mutagenesis, Site-Directed; Mutagens; Mutation, Missense; Nuclear Proteins; Phenotype; Recombination, Genetic; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Werner Syndrome Helicase | 2000 |
Expression of UMP1 is inducible by DNA damage and required for resistance of S. cerevisiae cells to UV light.
Topics: Cysteine Endopeptidases; DNA Damage; Gene Expression Regulation, Fungal; Hydroxyurea; Methyl Methanesulfonate; Molecular Chaperones; Multienzyme Complexes; Mutagens; Proteasome Endopeptidase Complex; Radiation Tolerance; Saccharomyces cerevisiae; Ultraviolet Rays | 2000 |
Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions.
Topics: Alleles; Amino Acid Motifs; Amino Acid Sequence; Cell Cycle Proteins; DNA Damage; DNA Replication; DNA-Binding Proteins; Fungal Proteins; Genes, Fungal; Homeodomain Proteins; Hydroxyurea; Methyl Methanesulfonate; Minor Histocompatibility Antigens; Models, Molecular; Molecular Sequence Data; Mutation; Phenotype; Protein Structure, Quaternary; Protein Subunits; Proto-Oncogene Proteins c-bcl-2; Replication Protein C; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Suppression, Genetic; Telomere | 2000 |
Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae.
Topics: Cell Cycle Proteins; Cell Division; Checkpoint Kinase 2; Cyclin B; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flow Cytometry; Fungal Proteins; Genotype; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Methyl Methanesulfonate; Models, Genetic; Mutagens; Mutation; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcription, Genetic; Ultraviolet Rays | 2001 |
Different domains of Sgs1 are required for mitotic and meiotic functions.
Topics: Alleles; Cell Cycle Proteins; DNA Helicases; Dose-Response Relationship, Drug; Fungal Proteins; Gene Expression Regulation, Fungal; Genetic Complementation Test; Genotype; Homeodomain Proteins; Hydroxyurea; Meiosis; Methyl Methanesulfonate; Mitosis; Mutagenesis, Site-Directed; Mutagens; Mutation, Missense; Phenotype; Plasmids; Recombination, Genetic; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Sister Chromatid Exchange; Spores, Fungal; Transfection | 2000 |
The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors.
Topics: 4-Nitroquinoline-1-oxide; Camptothecin; Cycloheximide; DNA Helicases; Drug Resistance, Microbial; Ethylmaleimide; Hydroxyurea; Methyl Methanesulfonate; Mitoxantrone; Mutagenesis; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Topoisomerase I Inhibitors | 2001 |
Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint control.
Topics: Catalytic Domain; Cell Cycle; Checkpoint Kinase 1; DNA Damage; DNA Polymerase II; Gene Expression; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Mutagenesis; Mutagens; Nucleic Acid Synthesis Inhibitors; Protein Kinases; S Phase; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2001 |
Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: studies of fusion proteins.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Binding Sites; Cloning, Molecular; DNA Helicases; DNA Topoisomerases, Type I; Gene Deletion; Genetic Complementation Test; Humans; Hydroxyurea; Methyl Methanesulfonate; Mutagenesis; Mutagenesis, Site-Directed; Recombinant Fusion Proteins; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Deletion | 2001 |
In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta.
Topics: Alanine; Alleles; Amino Acid Motifs; Amino Acid Sequence; Base Pair Mismatch; Binding Sites; Catalysis; Conserved Sequence; Diploidy; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Primers; DNA Repair; DNA-Directed DNA Polymerase; Dose-Response Relationship, Radiation; Frameshift Mutation; Heterozygote; Homozygote; Hydroxyurea; Methyl Methanesulfonate; Models, Genetic; Molecular Sequence Data; Mutation; Phenotype; Plasmids; Point Mutation; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Tyrosine; Ultraviolet Rays | 2001 |
Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint.
Topics: Alkylating Agents; Blotting, Northern; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Flow Cytometry; G2 Phase; Gene Deletion; Hydroxyurea; Methyl Methanesulfonate; Mitosis; Models, Biological; Mutation; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Ultraviolet Rays | 2001 |
Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Nucleus; Cell Separation; Checkpoint Kinase 2; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flow Cytometry; Fungal Proteins; G2 Phase; Galactose; Genotype; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Kinetics; Methyl Methanesulfonate; Mitosis; Mutagens; Nocodazole; Nucleic Acid Synthesis Inhibitors; Phosphoproteins; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae Proteins; Time Factors; Ultraviolet Rays | 2001 |
Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Cycle Proteins; Cell Separation; Chromosomal Proteins, Non-Histone; Chromosome Deletion; Cloning, Molecular; Crosses, Genetic; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Epistasis, Genetic; Flow Cytometry; Fungal Proteins; Gamma Rays; Gene Deletion; Genotype; Humans; Hydroxyurea; Methyl Methanesulfonate; Mice; Models, Genetic; Molecular Sequence Data; Nuclear Proteins; Phosphoproteins; Recombination, Genetic; S Phase; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid; Sister Chromatid Exchange; Telomere; Time Factors | 2001 |
SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases.
Topics: Cell Division; DNA Helicases; Gene Dosage; Genes, Fungal; Genes, Suppressor; Genetic Complementation Test; Hydroxyurea; Methyl Methanesulfonate; Models, Genetic; Mutagens; Mutation; Phenotype; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Suppression, Genetic | 2002 |
Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.
Topics: Adenosine Triphosphatases; Blotting, Northern; Cell Cycle Proteins; Cell Nucleus; Cell Survival; Checkpoint Kinase 2; Cytoplasm; DNA Helicases; Dose-Response Relationship, Drug; Exoribonucleases; Fungal Proteins; Hydroxyurea; Kinetics; Methyl Methanesulfonate; Models, Genetic; Phenotype; Protein Kinases; Protein Serine-Threonine Kinases; RNA; RNA Processing, Post-Transcriptional; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Time Factors; Transcription, Genetic; Two-Hybrid System Techniques; Up-Regulation | 2002 |
Overlapping roles of the spindle assembly and DNA damage checkpoints in the cell-cycle response to altered chromosomes in Saccharomyces cerevisiae.
Topics: Calcium-Binding Proteins; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Chromosome Aberrations; Chromosomes, Fungal; DNA Damage; Fungal Proteins; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Mad2 Proteins; Methyl Methanesulfonate; Mutation; Nuclear Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spindle Apparatus | 2002 |
The fission yeast pfh1(+) gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase.
Topics: Adenosine Triphosphatases; Alleles; Catalysis; Cell Cycle Proteins; Cell Nucleus; Conserved Sequence; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA, Fungal; G2 Phase; Gene Deletion; Genes, Essential; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Nuclear Proteins; RNA, Fungal; S Phase; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Suppression, Genetic; Temperature | 2002 |
A method for assaying the sensitivity of Drosophila replication checkpoint mutants to anti-cancer and DNA-damaging drugs.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 1; Cisplatin; Cytarabine; DNA Damage; DNA Replication; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Female; Genes, Insect; Hydroxyurea; Male; Methyl Methanesulfonate; Mutation; Nuclear Proteins; Paraquat; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Schizosaccharomyces pombe Proteins | 2002 |
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.
Topics: DNA Damage; Gene Expression Profiling; Genome, Fungal; Hydroxyurea; Methyl Methanesulfonate; Mutation; S Phase; Saccharomyces cerevisiae | 2002 |
ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase.
Topics: Cell Cycle Proteins; Cell Survival; Checkpoint Kinase 2; Chromosomes, Fungal; Cycloheximide; DNA Damage; DNA Replication; DNA-Binding Proteins; DNA, Fungal; Dose-Response Relationship, Drug; Fungal Proteins; Gene Expression Regulation, Fungal; Genes, cdc; Hydroxyurea; Methyl Methanesulfonate; Mutation; Nucleic Acid Conformation; Origin Recognition Complex; Phosphorylation; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Replication Origin; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin | 2002 |
The Drosophila chk2 gene loki is essential for embryonic DNA double-strand-break checkpoints induced in S phase or G2.
Topics: Animals; Checkpoint Kinase 2; Chromosome Mapping; DNA Damage; DNA Replication; Drosophila; Drosophila Proteins; Embryo, Nonmammalian; G2 Phase; Genotype; Hydroxyurea; Meiosis; Methyl Methanesulfonate; Mutagens; Nuclear Proteins; Phylogeny; Protein Serine-Threonine Kinases; S Phase | 2003 |
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.
Topics: Adenosine Triphosphatases; Alkylating Agents; Bloom Syndrome; DNA Helicases; DNA Repair; DNA Replication; DNA, Fungal; Enzyme Inhibitors; Exodeoxyribonuclease V; Exodeoxyribonucleases; Genetic Complementation Test; Humans; Hydroxyurea; Methyl Methanesulfonate; Protein Interaction Mapping; RecQ Helicases; Ribonucleotide Reductases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature | 2003 |
Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.
Topics: Amino Acid Sequence; Binding Sites; Cell Cycle Proteins; Cell Nucleus; Chromosomal Proteins, Non-Histone; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Exodeoxyribonucleases; Hydroxyurea; Methyl Methanesulfonate; Molecular Sequence Data; Mutation; Nuclear Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid; Telomere; Two-Hybrid System Techniques; Ultraviolet Rays | 2003 |
Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents.
Topics: Antineoplastic Agents, Alkylating; Aphidicolin; Ataxia Telangiectasia Mutated Proteins; Benzofurans; Cell Cycle Proteins; Checkpoint Kinase 1; Comet Assay; Cyclohexanecarboxylic Acids; Cyclohexenes; DNA Damage; DNA Replication; DNA-Binding Proteins; Duocarmycins; Enzyme Inhibitors; Fibroblasts; HeLa Cells; Histones; Humans; Hydroxyurea; Indoles; Methyl Methanesulfonate; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Replication Protein A; S Phase; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2003 |
A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.
Topics: Alleles; DNA Damage; DNA Repair; DNA-Binding Proteins; Epistasis, Genetic; Gamma Rays; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Mutation; Protein Binding; Radiation Tolerance; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Replication Protein A; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Telomere; Ultraviolet Rays | 2003 |
Visualization of altered replication dynamics after DNA damage in human cells.
Topics: DNA; DNA Damage; Flow Cytometry; HeLa Cells; Humans; Hydroxyurea; Infrared Rays; Methyl Methanesulfonate; Microscopy, Confocal; Radiation, Ionizing; S Phase; Time Factors | 2004 |
The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea.
Topics: Cadmium; DNA Damage; Drug Resistance, Fungal; Enzyme Inhibitors; Genes, Fungal; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Methyl Methanesulfonate; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Repressor Proteins; Ribonucleotide Reductases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2004 |
Relative cytotoxicity values at the lowest effective concentration for 12 positive chemicals in the in vitro micronucleus test utilizing Chinese hamster ovary cells.
Topics: Animals; Benz(a)Anthracenes; Bleomycin; Cell Count; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Cyclophosphamide; Dactinomycin; Dose-Response Relationship, Drug; Etoposide; Female; Griseofulvin; Hazardous Substances; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Mitomycin; Phenol; Vinblastine | 2004 |
DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast.
Topics: Carrier Proteins; Cell Cycle Proteins; Checkpoint Kinase 2; Culture Media; DNA; DNA Replication; DNA, Fungal; Flow Cytometry; Green Fluorescent Proteins; Hydroxyurea; Immunoblotting; Immunoprecipitation; Indoles; Mad2 Proteins; Methyl Methanesulfonate; Mitosis; Mutagens; Mutation; Nuclear Proteins; Phenotype; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Spindle Apparatus; Temperature; Time Factors; Tyrosine; Ultraviolet Rays | 2004 |
Ccr4-not complex mRNA deadenylase activity contributes to DNA damage responses in Saccharomyces cerevisiae.
Topics: DNA Damage; DNA-Binding Proteins; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Nucleic Acid Synthesis Inhibitors; Phenotype; Point Mutation; Ribonucleases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2005 |
The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.
Topics: Adenosine Triphosphatases; Blotting, Western; DNA Damage; DNA Helicases; DNA Topoisomerases, Type I; Hydroxyurea; Immunoprecipitation; Methyl Methanesulfonate; Mutation; Oligonucleotides; Plasmids; Protein Binding; Protein Structure, Tertiary; RecQ Helicases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Species Specificity; Ultraviolet Rays | 2005 |
Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.
Topics: Alkylation; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; DNA, Fungal; DNA, Single-Stranded; Genome, Fungal; Genomic Instability; Hydroxyurea; Methyl Methanesulfonate; Mitosis; Mutation; Protein Binding; Protein Serine-Threonine Kinases; S Phase; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription Factors | 2005 |
A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.
Topics: Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; DNA Replication; DNA-Binding Proteins; DNA, Fungal; Drug Resistance, Fungal; Fungal Proteins; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Mutation; Origin Recognition Complex; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Two-Hybrid System Techniques | 2005 |
Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.
Topics: Cell Cycle Proteins; Checkpoint Kinase 2; DNA Replication; DNA-Binding Proteins; DNA, Ribosomal; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Mutation; Nucleic Acid Synthesis Inhibitors; Protein Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2005 |
Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity.
Topics: DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Exodeoxyribonucleases; Exonucleases; Gamma Rays; Hydroxyurea; Immunoprecipitation; Methyl Methanesulfonate; Multiprotein Complexes; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomere | 2005 |
Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.
Topics: Alkylating Agents; Alleles; Animals; Bacterial Proteins; Cell Cycle; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; DNA; DNA Repair; DNA Replication; DNA-Binding Proteins; DNA, Single-Stranded; Escherichia coli; Hydroxyurea; Immunoprecipitation; Luminescent Proteins; Methyl Methanesulfonate; Mice; Models, Genetic; Mutation; Plasmids; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Temperature; Transcription Factors; Two-Hybrid System Techniques | 2005 |
Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta.
Topics: Amino Acid Sequence; Amino Acid Substitution; Cell Cycle; DNA Polymerase III; DNA Replication; Hydroxyurea; Methyl Methanesulfonate; Mutagenesis, Site-Directed; Mutation; Phenotype; Saccharomyces cerevisiae | 2006 |
P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.
Topics: Antineoplastic Agents; Aphidicolin; Cell Cycle; Cell Proliferation; Cells, Cultured; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; DNA Repair; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Humans; Hydroxyurea; Lung Neoplasms; Methyl Methanesulfonate; Mutagens; Proliferating Cell Nuclear Antigen; Ubiquitin; Ultraviolet Rays | 2006 |
Checkpoint functions are required for normal S-phase progression in Saccharomyces cerevisiae RCAF- and CAF-I-defective mutants.
Topics: Cell Cycle Proteins; Checkpoint Kinase 2; Chromatin Assembly Factor-1; Chromosomal Proteins, Non-Histone; DNA Damage; DNA Replication; DNA-Binding Proteins; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Models, Biological; Molecular Chaperones; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2006 |
Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Cycle; Cell Cycle Proteins; Cell Division; Checkpoint Kinase 1; Cytochalasin B; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Down-Regulation; Embryo, Nonmammalian; Endodeoxyribonucleases; Genes, cdc; Germ Cells; Hydroxyurea; Ligases; Methyl Methanesulfonate; Mitosis; Models, Biological; Mutation; Phosphotransferases; Protein Kinases; Rad51 Recombinase; Recombinases; RNA, Small Interfering; Ubiquitin-Conjugating Enzymes; Ultraviolet Rays | 2006 |
Selective degradation of reverse gyrase and DNA fragmentation induced by alkylating agent in the archaeon Sulfolobus solfataricus.
Topics: Alkylating Agents; Archaeal Proteins; DNA Fragmentation; DNA Topoisomerases, Type I; DNA, Archaeal; Hydroxyurea; Metalloproteases; Methyl Methanesulfonate; Sulfolobus solfataricus | 2006 |
Limiting amounts of budding yeast Rad53 S-phase checkpoint activity results in increased resistance to DNA alkylation damage.
Topics: Alleles; Antineoplastic Agents, Alkylating; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; DNA Replication; Drug Resistance; Gene Deletion; Hydroxyurea; Methyl Methanesulfonate; Mutation; Protein Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2006 |
A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition.
Topics: Cell Cycle Proteins; DNA-Binding Proteins; G1 Phase; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Nucleic Acid Synthesis Inhibitors; RNA Splicing; RNA Splicing Factors; RNA-Binding Proteins; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Critical role of DNA checkpoints in mediating genotoxic-stress-induced filamentous growth in Candida albicans.
Topics: Alleles; Amino Acid Sequence; Aphidicolin; Candida albicans; Cell Cycle; DNA Damage; DNA Replication; DNA, Fungal; Fungal Proteins; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Ribonucleotide Reductases; Ultraviolet Rays | 2007 |
Schistosoma mansoni: the IMP4 gene is involved in DNA repair/tolerance after treatment with alkylating agent methyl methane sulfonate.
Topics: Alkylating Agents; Amino Acid Sequence; Animals; Base Sequence; DNA Repair; DNA, Complementary; Escherichia coli; Gene Library; Genetic Complementation Test; Hydroxyurea; Methyl Methanesulfonate; Molecular Sequence Data; Mutation; Nucleic Acid Synthesis Inhibitors; Phenotype; Polymerase Chain Reaction; Ribosomal Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schistosoma mansoni; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 2007 |
Global analysis of functional surfaces of core histones with comprehensive point mutants.
Topics: Amino Acid Sequence; Histones; Hydroxyurea; Methyl Methanesulfonate; Models, Molecular; Molecular Sequence Data; Mutagens; Nucleosomes; Phenotype; Point Mutation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Uracil | 2007 |
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.
Topics: Acetylation; Amino Acid Sequence; Camptothecin; Catalytic Domain; Chromosome Breakage; DNA Damage; DNA Replication; Histone Acetyltransferases; Histones; Hydroxyurea; Lysine; Methyl Methanesulfonate; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutagens; Mutation; Recombinant Proteins; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid | 2007 |
An essential role for Drosophila hus1 in somatic and meiotic DNA damage responses.
Topics: Aneuploidy; Animals; Apoptosis; Body Patterning; Cell Cycle; Cell Cycle Proteins; DNA Damage; Drosophila; Drosophila Proteins; Female; Hydroxyurea; Larva; Male; Meiosis; Methyl Methanesulfonate; Mutagens; Mutation; Oocytes; Protein Binding; S Phase; X-Rays | 2007 |
Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3.
Topics: Cell Proliferation; DNA Repair; DNA-Binding Proteins; Epistasis, Genetic; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Models, Biological; Mutant Proteins; Mutation; Recombination, Genetic; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Detection of excision repaired DNA damage in the comet assay by using Ara-C and hydroxyurea in three different cell types.
Topics: Blood Cells; Cell Line; Cell Survival; Comet Assay; Cytarabine; DNA Damage; DNA Repair; Ethyl Methanesulfonate; Humans; Hydroxyurea; Methyl Methanesulfonate | 2009 |
Minichromosome maintenance proteins interact with checkpoint and recombination proteins to promote s-phase genome stability.
Topics: Amino Acid Substitution; Bleomycin; Cell Cycle Proteins; Cell Survival; Checkpoint Kinase 2; DNA Damage; DNA-Binding Proteins; Gamma Rays; Genomic Instability; HeLa Cells; Humans; Hydroxyurea; Methyl Methanesulfonate; Minichromosome Maintenance Complex Component 4; Mutagens; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Proline; Protein Kinases; Protein Serine-Threonine Kinases; Rad51 Recombinase; Recombination, Genetic; RNA, Small Interfering; S Phase; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Temperature; Time Factors; Transfection | 2008 |
The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.
Topics: Blotting, Western; DNA Damage; DNA Replication; Exodeoxyribonucleases; Fibroblasts; Flow Cytometry; Humans; Hydroxyurea; Methyl Methanesulfonate; RecQ Helicases; RNA Interference; Werner Syndrome Helicase | 2008 |
Analysis of Saccharomyces cerevisiae histone H3 mutants reveals the role of the alphaN helix in nucleosome function.
Topics: Alanine; Alkylating Agents; Amino Acid Sequence; Amino Acid Substitution; Cell Cycle Proteins; DNA Mutational Analysis; Histones; Hydroxyurea; Methyl Methanesulfonate; Molecular Chaperones; Molecular Sequence Data; Mutation; Nuclear Proteins; Nucleosomes; Protein Structure, Secondary; Ribonucleotide Reductases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tandem Repeat Sequences | 2008 |
Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.
Topics: Carrier Proteins; Cell Cycle Proteins; Cell Nucleus; Centromere; Chromosomal Proteins, Non-Histone; DNA Replication; DNA, Fungal; Heterochromatin; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Nucleic Acid Synthesis Inhibitors; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Small Ubiquitin-Related Modifier Proteins; Telomere | 2008 |
Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpoint.
Topics: Cell Cycle Proteins; Checkpoint Kinase 2; DNA Polymerase I; DNA Replication; Hydroxyurea; Methyl Methanesulfonate; Models, Biological; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spindle Apparatus; Telomere; Telomere-Binding Proteins; Temperature | 2009 |
Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork.
Topics: Cell Line; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Hydroxyurea; Methyl Methanesulfonate; Proliferating Cell Nuclear Antigen; Ubiquitination; Ultraviolet Rays | 2009 |
Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint.
Topics: Bleomycin; Cell Cycle Proteins; Checkpoint Kinase 2; Deoxyribonucleases, Type II Site-Specific; DNA Breaks; DNA Repair; DNA Replication; DNA, Fungal; Hydroxyurea; Methyl Methanesulfonate; Models, Genetic; Mutagens; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Rad51 Recombinase; Rad52 DNA Repair and Recombination Protein; Recombination, Genetic; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2009 |
HBx protein modulates PI3K/Akt pathway to overcome genotoxic stress-induced destabilization of cyclin D1 and arrest of cell cycle.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; cdc25 Phosphatases; Cell Cycle; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hepatitis B virus; Humans; Hydroxyurea; Methyl Methanesulfonate; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Trans-Activators; Up-Regulation; Viral Regulatory and Accessory Proteins | 2009 |
Stress-induced phenotypic switching in Candida albicans.
Topics: Candida albicans; DNA Damage; Gene Deletion; Gene Dosage; Gene Expression Regulation, Fungal; Genes, Fungal; Genes, Switch; Hydroxyurea; Methyl Methanesulfonate; Oxidative Stress; Phenotype; S Phase; Stress, Physiological | 2009 |
HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy.
Topics: Antineoplastic Agents; AT-Hook Motifs; Cell Line, Tumor; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Drug Resistance, Neoplasm; Genome, Human; HMGA2 Protein; Humans; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Neoplasms; Phosphorus-Oxygen Lyases | 2009 |
TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
Topics: CDC2 Protein Kinase; Cell Survival; DNA Damage; DNA Replication; Enzyme Activation; Gene Expression Regulation, Fungal; Gene Silencing; Hydroxyurea; Methyl Methanesulfonate; Mitosis; Multiprotein Complexes; Mutagens; Nucleic Acid Synthesis Inhibitors; Oligonucleotide Array Sequence Analysis; Protein Kinases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Telomere | 2009 |
The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.
Topics: Amino Acid Substitution; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; DNA Replication; Hydroxyurea; Methyl Methanesulfonate; Minichromosome Maintenance Complex Component 6; Mutation; Protein Binding; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Stress, Physiological | 2009 |
The Saccharomyces cerevisiae Rad6 postreplication repair and Siz1/Srs2 homologous recombination-inhibiting pathways process DNA damage that arises in asf1 mutants.
Topics: Cell Cycle Proteins; Chromosomes, Fungal; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; DNA, Fungal; Hydroxyurea; Methyl Methanesulfonate; Molecular Chaperones; Mutation; Protein Serine-Threonine Kinases; Recombination, Genetic; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination | 2009 |
Arabidopsis actin-related protein ARP5 in multicellular development and DNA repair.
Topics: Animals; Antibiotics, Antineoplastic; Arabidopsis; Arabidopsis Proteins; Bleomycin; Cell Nucleus; DNA Breaks, Double-Stranded; DNA Repair; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Reporter; Genetic Complementation Test; Hydroxyurea; Methyl Methanesulfonate; Microfilament Proteins; Mutagens; Nicotiana; Nucleic Acid Synthesis Inhibitors; Phenotype; Promoter Regions, Genetic; Recombinant Fusion Proteins; Seedlings; Transgenes | 2009 |
Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.
Topics: Adaptor Proteins, Signal Transducing; Adenylyl Cyclases; Antifungal Agents; Cadmium Compounds; Cell Cycle Proteins; Cell Wall; Cluster Analysis; Congo Red; Cryptococcus neoformans; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dioxoles; DNA Damage; Down-Regulation; Drug Resistance, Fungal; Fungal Proteins; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Fungal; GTP-Binding Protein alpha Subunits; Heat-Shock Proteins; Hydroxyurea; Methyl Methanesulfonate; Models, Biological; Mutation; Osmotic Pressure; Oxidative Stress; Pyrroles; Pyruvaldehyde; ras Proteins; Signal Transduction; Stress, Physiological; Sulfates; Superoxides; Up-Regulation | 2010 |
Functional characterization of the PP2C phosphatase CaPtc2p in the human fungal pathogen Candida albicans.
Topics: Antifungal Agents; Azoles; Candida albicans; Cytoplasm; Fungal Proteins; Gene Deletion; Gene Expression Profiling; Humans; Hydroxyurea; Methyl Methanesulfonate; Mitochondria; Phosphoprotein Phosphatases; Phylogeny; Protein Phosphatase 2C; Sequence Homology, Amino Acid; Sodium Dodecyl Sulfate | 2010 |
Global analysis for functional residues of histone variant Htz1 using the comprehensive point mutant library.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Benomyl; Caffeine; Drug Resistance, Fungal; Gene Library; Histones; Hydroxyurea; Isoleucine; Methyl Methanesulfonate; Molecular Sequence Data; Mutagens; Nucleic Acid Synthesis Inhibitors; Phenotype; Phenylalanine; Phosphodiesterase Inhibitors; Point Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Tubulin Modulators | 2011 |
Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae.
Topics: Actins; Blotting, Western; CDC28 Protein Kinase, S cerevisiae; Cell Cycle Proteins; Cell Wall; Chitin; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Hydroxyurea; Methyl Methanesulfonate; Microscopy, Fluorescence; Mutagens; Mutation; Nucleic Acid Synthesis Inhibitors; Protein-Tyrosine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sphingolipids; Type C Phospholipases | 2011 |
Histone H3 lysine 56 acetylation and the response to DNA replication fork damage.
Topics: Acetylation; Antineoplastic Agents; Camptothecin; DNA Damage; DNA Repair; DNA Replication; DNA, Fungal; Histones; Hydroxyurea; Lysine; Methyl Methanesulfonate; Mutagens; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2012 |
DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1.
Topics: Camptothecin; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; DNA Replication; G1 Phase; Gene Expression Regulation, Fungal; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Repressor Proteins; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2012 |
Improved gene targeting frequency in marine-derived filamentous fungus Aspergillus glaucus by disrupting ligD.
Topics: Aquatic Organisms; Aspergillus; DNA End-Joining Repair; Gene Targeting; Genes, Fungal; Genetic Loci; Hydroxyurea; Methyl Methanesulfonate; Mutation; Phenotype; Sequence Homology, Nucleic Acid; Transformation, Genetic; Ultraviolet Rays | 2012 |
Pph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans.
Topics: Candida albicans; Cell Cycle Proteins; DNA Damage; DNA, Fungal; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Fungal; Hydroxyurea; Methyl Methanesulfonate; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases | 2012 |
Turned on by genotoxic stress.
Topics: Camptothecin; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Damage; DNA Replication; Gene Expression Regulation, Fungal; Genes, cdc; Hydroxyurea; Methyl Methanesulfonate; Phosphorylation; Protein Serine-Threonine Kinases; Repressor Proteins; Saccharomyces cerevisiae Proteins; Saccharomycetales | 2012 |
Two serine phosphorylation sites in the C-terminus of Rad9 are critical for 9-1-1 binding to TopBP1 and activation of the DNA damage checkpoint response in HeLa cells.
Topics: Carrier Proteins; Cell Cycle Proteins; Checkpoint Kinase 1; DNA Damage; DNA Repair; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Silencing; HeLa Cells; Humans; Hydroxyurea; Methyl Methanesulfonate; Nuclear Proteins; Phosphorylation; Protein Binding; Protein Kinases; RNA Interference; Serine; Ultraviolet Rays | 2012 |
DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.
Topics: Alkylating Agents; Cell Cycle Proteins; DNA Damage; DNA Polymerase I; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Genomic Instability; Hydroxyurea; Methyl Methanesulfonate; Mutation; Nuclear Proteins; S Phase; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Ultraviolet Rays | 2012 |
Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and rapamycin in Candida albicans.
Topics: Antifungal Agents; Candida albicans; Cloning, Molecular; DNA Damage; DNA, Fungal; Epistasis, Genetic; Fungal Proteins; Gene Deletion; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Phenotype; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus | 2013 |
Physical mapping and cloning of RAD56.
Topics: Acetylation; Bleomycin; Camptothecin; Chromosome Mapping; Cloning, Molecular; DNA Damage; DNA Repair; DNA, Fungal; Hydroxyurea; Methyl Methanesulfonate; Mutation; N-Terminal Acetyltransferase B; Phenotype; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Analysis, DNA; X-Rays | 2013 |
Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway.
Topics: Carrier Proteins; Chromosomal Proteins, Non-Histone; DEAD-box RNA Helicases; DNA Damage; Fanconi Anemia; Humans; Hydroxyurea; Methyl Methanesulfonate; Mutation; Proliferating Cell Nuclear Antigen; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sumoylation; Two-Hybrid System Techniques | 2013 |
The yeast copper response is regulated by DNA damage.
Topics: Cell Cycle Proteins; Checkpoint Kinase 2; Copper; DNA Damage; DNA-Binding Proteins; DNA, Fungal; Gene Expression Regulation, Fungal; Hydroxyurea; Methyl Methanesulfonate; Nuclear Proteins; Oxidation-Reduction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Transcription Factors | 2013 |
Knockouts of RecA-like proteins RadC1 and RadC2 have distinct responses to DNA damage agents in Sulfolobus islandicus.
Topics: Archaeal Proteins; DNA Damage; Hydroxyurea; Methyl Methanesulfonate; Sulfolobus; Ultraviolet Rays | 2013 |
The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.
Topics: Alleles; Cell Cycle Proteins; Checkpoint Kinase 2; Chromatids; DNA Repair; Endodeoxyribonucleases; Exodeoxyribonucleases; Hydroxyurea; Kinetics; Methyl Methanesulfonate; Mutation; Phenotype; Replication Protein C; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomerase; Telomere; Temperature | 2014 |
Functions of Fun30 chromatin remodeler in regulating cellular resistance to genotoxic stress.
Topics: Chromatin Assembly and Disassembly; DNA Damage; DNA Repair; DNA Replication; DNA, Fungal; Homologous Recombination; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2015 |
Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.
Topics: Bacterial Proteins; Camptothecin; Carcinogenesis; Cell Cycle; Cell Separation; Chromosomes; DNA; DNA Copy Number Variations; DNA Replication; DNA, Ribosomal; Electrophoresis, Gel, Two-Dimensional; Flow Cytometry; Gene Dosage; Genomic Instability; Humans; Hydroxyurea; Luminescent Proteins; Methyl Methanesulfonate; Mutation; Replication Origin; Ribonuclease H; RNA; Saccharomyces cerevisiae | 2015 |
LAMMER kinase contributes to genome stability in Ustilago maydis.
Topics: Cell Cycle; Chromosome Segregation; Cloning, Molecular; DNA Repair; Epistasis, Genetic; Fungal Proteins; Genetic Complementation Test; Genetic Testing; Genomic Instability; Hydroxyurea; Meiosis; Methyl Methanesulfonate; Mutation; Phenotype; Protein Kinases; Recombination, Genetic; Ultraviolet Rays; Ustilago | 2015 |
The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage.
Topics: Acetylation; DNA Damage; Endoplasmic Reticulum Stress; Ethanol; Heat-Shock Response; HeLa Cells; Histones; Humans; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Sirolimus; Subcellular Fractions; Ubiquitinated Proteins; Ubiquitination | 2016 |
The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products.
Topics: Adenine; Alkylation; Camptothecin; Cisplatin; DNA Damage; DNA Polymerase beta; DNA Repair; DNA, Fungal; Epistasis, Genetic; Etoposide; Genes, Fungal; Genetic Loci; Homologous Recombination; Humans; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Models, Biological; Mutation; Mutation Rate; Protein Binding; Radiation, Ionizing; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ultraviolet Rays | 2016 |
Cell cycle-dependent positive and negative functions of Fun30 chromatin remodeler in DNA damage response.
Topics: Camptothecin; Cell Cycle Checkpoints; Cell Cycle Proteins; Chromatin Assembly and Disassembly; DNA Breaks, Double-Stranded; DNA Repair; DNA, Fungal; Hydroxyurea; Methyl Methanesulfonate; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Stress, Physiological; Transcription Factors | 2017 |
A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents.
Topics: Codon, Initiator; Cytotoxins; Gene Expression Regulation, Fungal; Genetic Engineering; Genetic Loci; Genetic Markers; Histidine; Hydroxyurea; Indenes; Methyl Methanesulfonate; Mutation; MutS Homolog 3 Protein; Peptide Elongation Factor 2; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2017 |
Systematic Identification of Determinants for Single-Strand Annealing-Mediated Deletion Formation in
Topics: Camptothecin; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Fungal; DNA, Single-Stranded; Doxorubicin; Gene Expression Profiling; Genomic Instability; Hydroxyurea; Methyl Methanesulfonate; Mutagens; Mutation; Nucleic Acid Synthesis Inhibitors; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2017 |
Yeast-based assays for characterization of the functional effects of single nucleotide polymorphisms in human DNA repair genes.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Proliferation; Computational Biology; Computer Simulation; Culture Media; DNA Repair; DNA-Binding Proteins; Escherichia coli; Genetic Techniques; Humans; Hydroxyurea; Ku Autoantigen; Methyl Methanesulfonate; Models, Molecular; Mutation; Polymorphism, Single Nucleotide; Saccharomyces cerevisiae; Sequence Alignment; Sequence Homology, Amino Acid; Ubiquitin-Protein Ligases; Ultraviolet Rays; Xeroderma Pigmentosum Group D Protein | 2018 |
Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae.
Topics: 4-Nitroquinoline-1-oxide; DNA Breaks, Double-Stranded; DNA, Fungal; Gene Expression Regulation, Fungal; Genome, Fungal; Genomic Instability; Homologous Recombination; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Molecular Chaperones; Mutation; Paraquat; Phleomycins; Quinolones; Rad51 Recombinase; Reactive Oxygen Species; Recombinational DNA Repair; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Superoxide Dismutase-1 | 2018 |
The
Topics: Animals; DNA Damage; DNA Repair; Drosophila melanogaster; Female; Humans; Hydroxyurea; Insect Proteins; Male; Methyl Methanesulfonate; Mutagens; Rad51 Recombinase; Radiation, Ionizing; Ubiquitin-Protein Ligases | 2020 |
Pseudohyphal Growth of the Emerging Pathogen Candida auris Is Triggered by Genotoxic Stress through the S Phase Checkpoint.
Topics: Adaptation, Physiological; Candida; DNA Damage; DNA, Fungal; Flucytosine; Host-Pathogen Interactions; Hydroxyurea; Hyphae; Methyl Methanesulfonate; Mutagens; S Phase Cell Cycle Checkpoints; Virulence | 2020 |
Homolog of Saccharomyces cerevisiae SLX4 is required for cell recovery from MMS-induced DNA damage in Candida albicans.
Topics: Candida albicans; Cell Cycle Checkpoints; DNA Damage; Endodeoxyribonucleases; Fungal Proteins; Hydroxyurea; Methyl Methanesulfonate; Phosphorylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2021 |
Yeast-based screening of cancer mutations in the DNA damage response protein Mre11 demonstrates importance of conserved capping domain residues.
Topics: Adenocarcinoma; Breast Neoplasms; DNA Damage; DNA Repair; Early Detection of Cancer; Endodeoxyribonucleases; Exodeoxyribonucleases; Female; Humans; Hydroxyurea; MCF-7 Cells; Methyl Methanesulfonate; Microorganisms, Genetically-Modified; MRE11 Homologue Protein; Mutation Rate; Protein Domains; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2021 |