methyl-ferulate has been researched along with prunasin* in 1 studies
1 other study(ies) available for methyl-ferulate and prunasin
| Article | Year |
|---|---|
Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation.
The aerial parts of Chrysanthemum coronarium L. were extracted with MeOH, and the concentrated extract was partitioned using EtOAc, n-BuOH, and H(2)O, successively. Repeated column chromatography of the EtOAc and n-BuOH fractions gave a new heterocycle, 5,5'-dibuthoxy-2,2'-bifuran (1) along with five known compounds: methyl trans-ferulate (2), prunasin (3), sambunigrin (4), pterolactam (5), and adenosine (6), which were identified by several spectroscopic methods including NMR and MS. This paper is the first report on the isolation of these compounds from C. coronarium L. The IC(50) values of compound 1 for human Acyl-CoA:cholesterol acyltransferase (hACAT)-1 and hACAT-2 were 0.16 mM and 0.19 mM, respectively. Compound 2 inhibited low-density lipoprotein (LDL) oxidation with an IC(50) value of 7.7 microM. Topics: Adenosine; Animals; Caffeic Acids; Cell Line; Chrysanthemum; Coumaric Acids; Furans; Glycosides; Humans; Lactams; Lipoproteins, LDL; Microsomes; Nitriles; Oxidation-Reduction; Plant Extracts; Rats; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2 | 2008 |