methyl-caffeate and ethyl-caffeate

To explore the in-vitro and in-vivo antimalarial potential of caffeic acid and derivatives.. Two common phenolic acids (caffeic acid and chlorogenic acid) were evaluated for in-vitro and in-vivo antiplasmodial activity in comparison with some semi-synthetic derivatives that were synthesized. An in-vitro assay based on plasmodial lactate dehydrogenase activity, and the classical in-vivo 5-day suppressive test from Peters on an artemisinin-resistant Plasmodium berghei strain was used. Parasitic stage sensitivity to ethyl caffeate was determined in this work.. Our study provides evidence for an antimalarial potential of caffeic acid derivatives which are common in several medicinal plants traditionally used against malaria. It also demonstrates the possibility to use such derivatives in the treatment of malaria.

Topics: Animals; Antimalarials; Caffeic Acids; Chlorogenic Acid; Inhibitory Concentration 50; Mice; Parasitic Sensitivity Tests; Plasmodium berghei

To investigate the chemical constituents from Xanthium mongolicum.. The constituents were isolated and purified by silicagel,Sephadex LH-20 column chromatography. Their structures were identified on the basis of spectral data and physiochemical characteristics.. Ten compounds were isolated and identified as hexadecanoic acid( 1), methyl 3, 4-dihydroxybenzoate ( 2), protocatechuic aldehyde( 3), caffeic acid methyl ester( 4), vanillic acid( 5), 4-hydroxybenzoic acid( 6), caffeic acid ethyl ester( 7), chlorogenic acid( 8), caffeic acid( 9), 3, 4-di-O-caffeoylquinic acid( 10).. Compounds 1 ~ 5,7 and 10 are isolated from this plant for the first time.

Topics: Caffeic Acids; Chlorogenic Acid; Hydroxybenzoates; Parabens; Quinic Acid; Vanillic Acid; Xanthium

Propyl caffeate has the highest antioxidant capacity in the caffeate alkyl esters family, but industrial production of propyl caffeate is hindered by low yields using either the chemical or enzymatic catalysis method. To set up a high-yield process for obtaining propyl caffeate, a novel chemoenzymatic synthesis method using lipase-catalyzed transesterification of an intermediate methyl caffeate or ethyl caffeate and 1-propanol in ionic liquid was established. The maximum propyl caffeate yield of 98.5% was obtained using lipase-catalyzed transesterification under the following optimal conditions: Novozym 435 as a biocatalyst, [Bmim][CF3SO3] as a medium, a molar ratio of methyl caffeate to 1-propanol of 1:5, a mass ratio of methyl caffeate to lipase of 1:20, and a reaction temperature of 60°C. The two-step conversion of caffeic acid to propyl caffeate via methyl caffeate is an efficient way to prepare propyl caffeate with an overall yield of 82.7%.

Topics: 1-Propanol; Biocatalysis; Caffeic Acids; Esterification; Ionic Liquids; Lipase; Substrate Specificity; Temperature