methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate and 5-hydroxy-6,8,11,14-eicosatetraenoic acid

methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate has been researched along with 5-hydroxy-6,8,11,14-eicosatetraenoic acid in 2 studies

Compound Research Comparison

Studies (methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate)	Trials (methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate)	Recent Studies (post-2010) (methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate)	Studies (5-hydroxy-6,8,11,14-eicosatetraenoic acid)	Trials (5-hydroxy-6,8,11,14-eicosatetraenoic acid)	Recent Studies (post-2010) (5-hydroxy-6,8,11,14-eicosatetraenoic acid)
16	0	0	648	5	54

Protein Interaction Comparison

Protein	Taxonomy	methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate (IC50)	5-hydroxy-6,8,11,14-eicosatetraenoic acid (IC50)
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)		2

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (50.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Colombo, C; Dotson, R; Ghai, G; Kimble, EF; Ku, EC; Lee, WH; Oglesby, TD; Raychaudhuri, A; Wasley, JW	1
Kruse-Elliott, KT; Olson, NC	1

Other Studies

2 other study(ies) available for methyl 2-((3,4-dihydro-3,4-dioxo-1-naphthalenyl)amino)benzoate and 5-hydroxy-6,8,11,14-eicosatetraenoic acid

Article	Year
Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models. Biochimica et biophysica acta, 1988, Apr-15, Volume: 959, Issue:3 Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Biotransformation; Blood Platelets; Calcimycin; Dexamethasone; Guinea Pigs; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naphthoquinones; ortho-Aminobenzoates; Pleurisy; Quinones; Rats; Rats, Inbred Strains; Sheep	1988
CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs. The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2 Topics: 6-Ketoprostaglandin F1 alpha; Albumins; Animals; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Cytokines; Dinoprost; Drug Synergism; Eicosanoids; Heart; Heart Diseases; Hydroxyeicosatetraenoic Acids; Indomethacin; Injections, Intravenous; Interleukin-1; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Lung Diseases; Naphthoquinones; ortho-Aminobenzoates; Swine; Thromboxane B2; Tumor Necrosis Factor-alpha; Vascular Resistance	1993

Article

Year

Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models.

Biochimica et biophysica acta, 1988, Apr-15, Volume: 959, Issue:3

Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Biotransformation; Blood Platelets; Calcimycin; Dexamethasone; Guinea Pigs; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Leukocytes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Naphthoquinones; ortho-Aminobenzoates; Pleurisy; Quinones; Rats; Rats, Inbred Strains; Sheep

1988

CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs.

The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2

Topics: 6-Ketoprostaglandin F1 alpha; Albumins; Animals; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Cytokines; Dinoprost; Drug Synergism; Eicosanoids; Heart; Heart Diseases; Hydroxyeicosatetraenoic Acids; Indomethacin; Injections, Intravenous; Interleukin-1; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Lung Diseases; Naphthoquinones; ortho-Aminobenzoates; Swine; Thromboxane B2; Tumor Necrosis Factor-alpha; Vascular Resistance

1993