Page last updated: 2024-08-25

methotrexate and vitamin b 12

methotrexate has been researched along with vitamin b 12 in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	34 (47.89)	18.7374
1990's	13 (18.31)	18.2507
2000's	10 (14.08)	29.6817
2010's	9 (12.68)	24.3611
2020's	5 (7.04)	2.80

Authors

Authors	Studies
Poirier, LA	1
Barak, AJ; Sorrell, MF; Tuma, DJ	1
Arsenian, FG; Iurkevich, AM; Miasishcheva, NV; Sof'ina, ZP	1
Van Der Weyden, MB	1
Marquet, J; Zittoun, J; Zittoun, R	1
Gatzemeier, U; Jüngst, G; Wagner, G	1
Canellos, GP	1
Reynolds, EH	1
Gajcy, H	1
Hoffbrand, AV; Linnell, JC; Matthews, DM; Quadros, EV	1
Hoffbrand, AV; Hooton, JW	1
Grzelakowska-Sztabert, B	1
Girdwood, RH	1
Bottiglieri, T; Carney, MW; Chanarin, I; Flynn, TG; Godfrey, PS; Laundy, M; Reynolds, EH; Toone, BK	1
Abels, J; Ermens, AA; Lindemans, J; Schoester, M	1
Gill, DS; Latham, J; Wickramasinghe, SN	1
Brodzki, M; Deptala, A; Konopka, L; Krämer, M; Pawelski, S; Swencz-Szczepanik, K	1
Abels, J; Ermens, AA; Kroes, AC; Lindemans, J; Schoester, M; van Lom, K	1
Abels, J; Kroes, AC; Lindemans, J; Schoester, M	1
Golenko, OD; Miasishcheva, NV; Nikolaeva, TG; Vares, IuV	1
Gerasimova, GK; Il'ina, NS; Miasishcheva, NV; Sof'ina, ZP	1
Gawthorne, JM; Smith, RM	1
DiGirolamo, PM; Fujii, K; Henderson, GB; Huennekens, FM; Jacobsen, DW; Neef, VG; Rader, JI	1
Bau, S; Jain, KK; Posener, LJ; Pow, CG	1
Hennemann, HH; Loewe, U	1
Salen, G; Schumacher, HR	1
Ellegaard, J; Esmann, V; Henriksen, L	1
Dawson, AA; Ogston, D	1
Herbert, V; Kelly, A; Metz, J; Swett, VC; Waxman, S	1
Sauer, H	1
Arsenian, FG; Gerasimova, GK; Golenko, OD; Miasishcheva, NV; Vares, IuV	1
Arsenian, FG; Golenko, OD; Miasishcheva, NV; Sof'ina, ZP	1
Fernandes-Costa, F; Metz, J; Miller, H	1
Gimsing, P; Hippe, E	1
Alarcón, GS; Austin, JS; Baggott, JE; Koopman, WJ; Krumdieck, CL; Lee, JY; Morgan, SL; Vaughn, WH; Veitch, TA	1
Fida, S; Wickramasinghe, SN	1
Arza, B; Barceló, MJ; Cadafalch, J; García-Die, F; Parellada, MM; Remacha, A	1
Kim, YI; Logan, JW; Mason, JB; Roubenoff, R	1
Crowe, SF; Ross, CK	1
Abad, LW; Dellaripa, P; Muldoon, BA; Nadeau, MR; Rosenberg, IH; Roubenoff, R; Selhub, J	1
Fiskerstrand, T; Refsum, H; Ueland, PM	1
Bhatt, HR; Bunker, CA; Farrell, AM	1
Blom, HJ; Giesendorf, BA; Haagsma, CJ; van de Putte, LB; van Oppenraaij-Emmerzaal, D; van Riel, PL; van't Hof, MA	1
Varela-Moreiras, G	1
Calvert, H	1
FERNBACH, DJ; SULLIVAN, MP; THURMAN, WG	1
FRIEDKIN, M	1
GREENSPAN, EM	1
COOPER, BA; LOWENSTEIN, L	1
Goldman, ID; Zhao, R	1
Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA	1
Ellingsen, T; Hornung, N; Poulsen, JH; Stengaard-Pedersen, K	1
Barut, Y; Direskeneli, H; Inanc, N; Ozdemir, A; Sahinoglu, S; Tarcin, O; Tiftikci, A; Uras, F; Yavuz, S	1
Bisbe, E; Castillo, J; García-Erce, JA; Pérez, C; Sáez, M	1
Demlova, R; Dusek, L; Sterba, J; Valik, D	1
Aamar, S; Abou Atta, I; Arbel, O; Ben-Yehuda, A; Berkun, Y; Dresner-Pollak, R; Friedman, G; Levartovsky, D; Orbach, H; Rubinow, A	1
Beri-Dexheimer, M; Guéant, JL; Marguerite, V; Merten, M; Ortiou, S	1
Chukoskie, L; Kamen, BA	1
Barendregt, PJ; Calasan, MB; de Jong, PH; de Jonge, R; de Rotte, MC; de Sonnaville, PB; Hazes, JM; Lindemans, J; Pluijm, SM; van der Lubbe, PA; van Zeben, D	1
Hughes, RM; Lawrence, DS; Lee, J; Marvin, CM; Oien, NP; Rodgers, ZL; Smith, WJ	1
Blatch, SA; Harrison, JF; Stabler, SP	1
Ding, S; Hughes, RM; Lawrence, DS; Marvin, CM; Oien, NP; Rodgers, ZL; Smith, WJ	1
Forster, VJ; McDonnell, A; McKay, JA; Theobald, R	1
Hodges, NJ; Kusari, F; O'Doherty, AM; Wojewodzic, MW	1
Akrout, R; Ayedi, F; Bahloul, Z; Ben Hamad, M; Chaabane, S; Keskes, L; Maalej, A; Marzouk, S; Messedi, M; Rebai, A; Turki, M	1
de Jonge, R; Fiocco, M; Heil, SG; Oosterom, N; Pieters, R; Smith, DEC; Tissing, WJE; van den Heuvel-Eibrink, MM; van Zelst, BD	1
Akin, AT; Karabulut, D; Kaymak, E; Kuloglu, N; Ozturk, E; Yakan, B	3
Chen, YC; Chiu, YH; Yang, E	1
Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R	1

Reviews

6 review(s) available for methotrexate and vitamin b 12

Article	Year
Chronic granulocytic leukemia. The Medical clinics of North America, 1976, Volume: 60, Issue:5 Topics: Alkaline Phosphatase; Blood Transfusion; Busulfan; Chromosomes, Human, 21-22 and Y; Humans; Hydroxyurea; Immunotherapy; Leukemia, Myeloid; Leukocytes; Methotrexate; Prednisone; Splenectomy; Vincristine; Vitamin B 12	1976
Neurological aspects of folate and vitamin B12 metabolism. Clinics in haematology, 1976, Volume: 5, Issue:3 Topics: Adult; Aged; Anemia, Megaloblastic; Anticonvulsants; Blood-Brain Barrier; Brain; Brain Diseases; Child; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Metabolism, Inborn Errors; Methotrexate; Middle Aged; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency	1976
Folic acid and vitamin B12: transport and conversion to coenzyme forms. Advances in enzyme regulation, 1974, Volume: 12 Topics: Animals; Biological Transport, Active; Cell Line; Cell Membrane; Coenzymes; Folic Acid; Kinetics; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Models, Biological; Mutation; NADP; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Vitamin B 12	1974
Nutritional regulation of homocysteine: effects of drugs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2001, Volume: 55, Issue:8 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6	2001
Folate status and the safety profile of antifolates. Seminars in oncology, 2002, Volume: 29, Issue:2 Suppl 5 Topics: Antimetabolites, Antineoplastic; Dietary Supplements; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Humans; Hydroxymethyl and Formyl Transferases; Methotrexate; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Thymidylate Synthase; Vitamin B 12	2002
ENZYMATIC ASPECTS OF FOLIC ACID. Annual review of biochemistry, 1963, Volume: 32 Topics: Amidohydrolases; Aminopterin; Chromatography; Clostridium; Escherichia coli; Floxuridine; Folic Acid; Ligases; Liver; Lyases; Methionine; Methotrexate; Micrococcus; Oxidoreductases; Pseudomonas; Research; Spectrophotometry; Transferases; Tritium; Vitamin B 12	1963

Trials

5 trial(s) available for methotrexate and vitamin b 12

Article	Year
Enhancement of recovery from psychiatric illness by methylfolate. Lancet (London, England), 1990, Aug-18, Volume: 336, Issue:8712 Topics: Adult; Aged; Depressive Disorder; Double-Blind Method; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Methotrexate; Middle Aged; Randomized Controlled Trials as Topic; Schizophrenia; Vitamin B 12	1990
Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Annals of internal medicine, 1994, Dec-01, Volume: 121, Issue:11 Topics: Adult; Aged; Arthritis, Rheumatoid; Diet; Double-Blind Method; Drug Therapy, Combination; Erythrocytes; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Patient Dropouts; Treatment Outcome; Vitamin B 12	1994
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis. Annals of the rheumatic diseases, 1999, Volume: 58, Issue:2 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Digestive System; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sulfasalazine; Vitamin B 12	1999
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. Arthritis and rheumatism, 2004, Volume: 50, Issue:10 Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12	2004
Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate. Arthritis and rheumatism, 2013, Volume: 65, Issue:11 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Monitoring; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Predictive Value of Tests; Prospective Studies; Vitamin B 12; Vitamin B 6	2013

Other Studies

60 other study(ies) available for methotrexate and vitamin b 12

Article	Year
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes. Journal of the National Cancer Institute, 1975, Volume: 54, Issue:1 Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methotrexate; Neoplasms, Experimental; Nitrosamines; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Vitamin B 12	1975
Interaction of methotrexate with lipotropic factors in rat liver. Biochemical pharmacology, 1975, Jul-15, Volume: 24, Issue:13-14 Topics: Animals; Cholesterol; Choline; Choline Deficiency; Diet; Drug Synergism; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Phospholipids; Rats; Triglycerides; Vitamin B 12	1975
[Possibility of potentiating the antineoplastic effect of a folic acid antagonist by methylcobalamin analogs]. Vestnik Akademii meditsinskikh nauk SSSR, 1979, Issue:1 Topics: Adenocarcinoma; Animals; Drug Therapy, Combination; Female; Folic Acid Antagonists; Hybridization, Genetic; Intestinal Neoplasms; Leukemia, Experimental; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred Strains; Neoplasms, Experimental; Quinolinium Compounds; Uterine Cervical Neoplasms; Vitamin B 12	1979
Deoxyuridine metabolism in human megaloblastic marrow cells. Scandinavian journal of haematology, 1979, Volume: 23, Issue:1 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency	1979
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency. Blood, 1978, Volume: 51, Issue:1 Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency	1978
[Chemotherapy of inoperable endothoracic tumours (results of the Karrer and aco polycytostatic therapy) (author's transl)]. Praxis und Klinik der Pneumologie, 1979, Volume: 33, Issue:1 Topics: Adult; Aged; Bronchial Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Pyridoxine; Thoracic Neoplasms; Vinca Alkaloids; Vitamin B 12	1979
Vitamin B12 levels in drug-treated bacterial cells. Biochemical pharmacology, 1975, Jul-15, Volume: 24, Issue:13-14 Topics: Bacillus megaterium; Chloramphenicol; Dactinomycin; Dose-Response Relationship, Drug; Fluorouracil; Methotrexate; Puromycin; Sulfathiazoles; Vitamin B 12	1975
Synthesis of cobalamin coenzymes by human lymphocytes in vitro and the effect of folates and metabolic inhibitors. Blood, 1976, Volume: 48, Issue:4 Topics: Antimetabolites; Cobamides; Folic Acid; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Vitamin B 12	1976
Thymidine kinase in megaloblastic anaemia. British journal of haematology, 1976, Volume: 33, Issue:4 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Humans; Lectins; Lymphocyte Activation; Male; Methotrexate; Puromycin; Sonication; Thymidine Kinase; Vitamin B 12; Vitamin B 12 Deficiency	1976
Uptake of folate and its analogue-amethopterin by mouse L-cells. Acta biochimica Polonica, 1976, Volume: 23, Issue:4 Topics: Animals; Cells, Cultured; Chloromercuribenzoates; Cycloheximide; Dactinomycin; Folic Acid; Kinetics; L Cells; Methionine; Methotrexate; Mice; Vitamin B 12	1976
The nature of possible adverse reactions to co-trimoxazole. Scandinavian journal of infectious diseases. Supplementum, 1976, Issue:8 Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Humans; Methotrexate; Pyrimethamine; Sulfamethoxazole; Thrombocytopenia; Trimethoprim; Vitamin B 12	1976
Effect of nitrous oxide and methotrexate on folate coenzyme pools of blast cells from leukemia patients. Leukemia research, 1991, Volume: 15, Issue:2-3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Nitrous Oxide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Vitamin B 12	1991
Effects of phenytoin sodium on doubling time, deoxyuridine suppression, 3H-methotrexate uptake and 57Co-cyanocobalamin uptake in HL60 cells. Clinical and laboratory haematology, 1990, Volume: 12, Issue:1 Topics: Cell Division; Cell Survival; Cobalt Radioisotopes; Deoxyuridine; Folic Acid; Humans; Methotrexate; Phenytoin; Tritium; Tumor Cells, Cultured; Vitamin B 12	1990
Central nervous system involvement in non-Hodgkin's lymphomas. Haematology and blood transfusion, 1989, Volume: 32 Topics: Adult; Antineoplastic Agents; Central Nervous System Diseases; Cytophotometry; DNA, Neoplasm; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Protein Binding; Vitamin B 12	1989
Effect of cobalamin inactivation on folate metabolism of leukemic cells. Leukemia research, 1988, Volume: 12, Issue:11-12 Topics: Bone Marrow; Cell Line; Deoxyuridine; Female; Folic Acid; Humans; Leukemia; Male; Methotrexate; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12	1988
Enhanced therapeutic effect of methotrexate in experimental rat leukemia after inactivation of cobalamin (vitamin B12) by nitrous oxide. Cancer chemotherapy and pharmacology, 1986, Volume: 17, Issue:2 Topics: Animals; Blood Cell Count; Deoxyuridine; Drug Administration Schedule; Drug Synergism; Folic Acid; Leukemia, Experimental; Male; Methotrexate; Nitrous Oxide; Rats; Thymine Nucleotides; Vitamin B 12	1986
[Biosynthesis of cobalamin coenzymes in tumor and hematopoietic tissues in assessing methotrexate sensitivity]. Vestnik Akademii meditsinskikh nauk SSSR, 1986, Issue:5 Topics: Adenocarcinoma; Animals; Cobamides; Drug Evaluation, Preclinical; Hematopoietic Stem Cells; Male; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Splenic Neoplasms; Vitamin B 12	1986
[Effect of methylcobalamin on methotrexate transport in normal and tumorous tissues]. Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 99, Issue:6 Topics: Adenocarcinoma; Animals; Biological Transport; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Female; Intestine, Small; Kinetics; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Spleen; Vitamin B 12	1985
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver. The Biochemical journal, 1974, Volume: 142, Issue:1 Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency	1974
Life threatening disease. An unusual case of severe burns, meningitis, obstructive hydrocephalus and neuroblastoma in a child under age two. Clinical pediatrics, 1968, Volume: 7, Issue:5 Topics: Burns; Humans; Hydrocephalus; Infant; Male; Mechlorethamine; Meningitis; Methotrexate; Neuroblastoma; Polymyxins; Pseudomonas Infections; Vitamin B 12	1968
[Therapy of erythroleukemia]. Minerva medica, 1972, Apr-25, Volume: 63, Issue:31 Topics: Cytarabine; Folic Acid; Humans; Leukemia, Erythroblastic, Acute; Mercaptopurine; Methotrexate; Prednisone; Pyridoxine; Remission, Spontaneous; Vitamin B 12	1972
Metabolism of leukocytes in a case of acute leukemia. Acta haematologica, 1967, Volume: 37, Issue:5 Topics: Autoradiography; Child; DNA; Female; Folic Acid; Humans; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Methotrexate; Prednisone; Thymidine; Tritium; Uridine; Vincristine; Vitamin B 12	1967
Deficient folate activity during treatment of psoriasis with methotrexate diagnosed by determination of serine synthesis in lymphocytes. The British journal of dermatology, 1972, Volume: 87, Issue:3 Topics: Adult; Aged; Carbon Isotopes; Female; Folic Acid Deficiency; Formates; Humans; In Vitro Techniques; Intestinal Absorption; Lymphocytes; Male; Methotrexate; Middle Aged; Psoriasis; RNA; Serine; Vitamin B 12	1972
Thrombocytosis following thrombocytopenia in man. Postgraduate medical journal, 1969, Volume: 45, Issue:530 Topics: Anemia, Pernicious; Humans; Methotrexate; Neoplasms; Prednisone; Purpura, Thrombocytopenic; Thrombocytopenia; Thrombocytosis; Vitamin B 12	1969
Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans. British journal of haematology, 1968, Volume: 14, Issue:6 Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Female; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymine; Tritium; Uridine; Vitamin B 12; Vitamin B 12 Deficiency	1968
[Vitamin B12 as a regulator and methotrexate as an antagonist of folic acid metabolism. Pathophysiologic and clinical aspects]. Fortschritte der Medizin, 1983, Apr-21, Volume: 101, Issue:15 Topics: DNA; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate; Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency	1983
[Modifying action of cobalamins on the processes of tumor growth]. Vestnik Akademii meditsinskikh nauk SSSR, 1981, Issue:7 Topics: Animals; Antineoplastic Agents; Drug Therapy, Combination; Methotrexate; Mice; Neoplasms, Experimental; Organometallic Compounds; Palladium; Vitamin B 12	1981
[Kinetics of the cell proliferation of murine mammary adenocarcinoma under the influence of methylcobalamine]. Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:2 Topics: Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Female; Kinetics; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Stimulation, Chemical; Vitamin B 12	1980
Synthesis of DNA as shown by the deoxyuridine suppression test is normal in the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus). The British journal of nutrition, 1980, Volume: 44, Issue:3 Topics: Animals; Bone Marrow; Cells, Cultured; Chiroptera; Deoxyuridine; DNA; Folic Acid; Lymphocytes; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency	1980
Cobalamin-dependent metabolism in chronic myelogenous leukemia determined by deoxyuridine suppression test and the formiminoglutamic acid and methylmalonate excretion in urine. American journal of hematology, 1995, Volume: 49, Issue:2 Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Female; Formiminoglutamic Acid; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Malonates; Methotrexate; Middle Aged; Tetrahydrofolates; Thymidine; Tritium; Vitamin B 12	1995
Misincorporation of uracil into the DNA of folate- and B12-deficient HL60 cells. European journal of haematology, 1993, Volume: 50, Issue:3 Topics: Chromatography, Ion Exchange; DNA, Neoplasm; Folic Acid; Humans; Leukemia, Promyelocytic, Acute; Methotrexate; Tritium; Tumor Cells, Cultured; Uracil; Vitamin B 12	1993
The deoxyuridine suppression test in HIV-1 positive patients: the role of azydothymidine (AZT). European journal of haematology, 1996, Volume: 56, Issue:4 Topics: Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; Folic Acid; HIV Infections; HIV-1; Humans; Intestinal Absorption; Methotrexate; Vitamin B 12; Vitamin B 12 Deficiency; Zidovudine	1996
DNA hypomethylation in inflammatory arthritis: reversal with methotrexate. The Journal of laboratory and clinical medicine, 1996, Volume: 128, Issue:2 Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Vitamin B 12	1996
Effect of folate deficiency and folate and B12 excess on memory functioning in young chicks. Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:2 Topics: Animals; Avoidance Learning; Chickens; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Memory; Methionine; Methotrexate; Reflex; Time Factors; Vitamin B 12	1997
Abnormal homocysteine metabolism in rheumatoid arthritis. Arthritis and rheumatism, 1997, Volume: 40, Issue:4 Topics: Adult; Aged; Arthritis, Rheumatoid; Fasting; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	1997
Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Anesthetics, Inhalation; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12	1997
Screening of cobalamin metabolism in methotrexate-treated psoriatics. The British journal of dermatology, 1998, Volume: 138, Issue:6 Topics: Adult; Dermatologic Agents; Humans; Methotrexate; Methylmalonic Acid; Middle Aged; Psoriasis; Vitamin B 12	1998
CYCLOPHOSPHAMIDE THERAPY IN CHILDHOOD NEUROBLASTOMA. The New England journal of medicine, 1964, Jun-18, Volume: 270 Topics: Child; Cyclophosphamide; Dactinomycin; Humans; Infant; Mechlorethamine; Methotrexate; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Retroperitoneal Neoplasms; Toxicology; Urography; Vitamin B 12	1964
REGRESSION OF METASTATIC HEPATOMEGALY FROM MAMMARY CARCINOMA. CYTOTOXIC COMBINATION CHEMOTHERAPY WITH 5-FU. New York state journal of medicine, 1964, Oct-01, Volume: 64 Topics: Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Hepatomegaly; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Neoplasms; Prednisone; Testosterone; Thiotepa; Toxicology; Vitamin B 12	1964
RELATIVE FOLATE DEFICIENCY OF ERYTHROCYTES IN PERNICIOUS ANEMIA AND ITS CORRECTION WITH CYANOCOBALAMIN. Blood, 1964, Volume: 24 Topics: Anemia; Anemia, Hypochromic; Anemia, Pernicious; Biological Assay; Blood Chemical Analysis; Chromatography; Erythrocytes; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Lactobacillus; Metabolism; Methotrexate; Vitamin B 12	1964
Enter Alimta: a new generation antifolate. The oncologist, 2004, Volume: 9, Issue:3 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Pemetrexed; Vitamin B 12	2004
Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement. The Journal of rheumatology, 2004, Volume: 31, Issue:12 Topics: Arthritis, Rheumatoid; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methotrexate; Probability; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Vitamin B 12	2004
Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis. Rheumatology international, 2006, Volume: 26, Issue:3 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Methotrexate; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B Complex	2006
[Delayed improvement of anemia treated with intravenous iron and epoetin alfa after hip replacement surgery]. Revista espanola de anestesiologia y reanimacion, 2005, Volume: 52, Issue:8 Topics: Adult; Anemia, Hypochromic; Arthroplasty, Replacement, Hip; Chronic Disease; Colitis; Drug Therapy, Combination; Epoetin Alfa; Erythropoietin; Ferric Compounds; Folic Acid; Humans; Intestinal Polyps; Leucovorin; Malabsorption Syndromes; Male; Methotrexate; Osteoarthritis, Hip; Preoperative Care; Recombinant Proteins; Rectal Diseases; Remission Induction; Spondylitis, Ankylosing; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency	2005
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited. Clinical chemistry, 2006, Volume: 52, Issue:4 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12; Vitamin B Complex	2006
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis. The Journal of rheumatology, 2007, Volume: 34, Issue:8 Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cross-Sectional Studies; Female; Ferredoxin-NADP Reductase; Genotype; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Pteroylpolyglutamic Acids; Rheumatic Nodule; Severity of Illness Index; Vitamin B 12	2007
Cobalamin potentiates vinblastine cytotoxicity through downregulation of mdr-1 gene expression in HepG2 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2007, Volume: 20, Issue:6 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Cell Line, Tumor; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Promoter Regions, Genetic; Rhodamine 123; Up-Regulation; Vinblastine; Vitamin B 12	2007
Autism Speaks: meeting on folate metabolism and Autism spectrum disorders, March 19-20, 2009, Washington, DC. Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:3 Topics: Autistic Disorder; Biological Transport; Brain; Cognition Disorders; District of Columbia; Folic Acid; Genomic Instability; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, N-Methyl-D-Aspartate; Vitamin B 12	2011
Cell-mediated assembly of phototherapeutics. Angewandte Chemie (International ed. in English), 2014, Oct-06, Volume: 53, Issue:41 Topics: Cell Survival; Colchicine; Dexamethasone; Drug Carriers; Erythrocytes; Fluorescein; HeLa Cells; Humans; Light; Methotrexate; Prodrugs; Receptors, Glucocorticoid; Rhodamines; Tetrahydrofolate Dehydrogenase; Vitamin B 12	2014
The effects of folate intake on DNA and single-carbon pathway metabolism in the fruit fly Drosophila melanogaster compared to mammals. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2015, Volume: 189 Topics: Animals; Anti-Bacterial Agents; Bacteria; Carbon; Carbon Cycle; DNA; Drosophila melanogaster; Eating; Folic Acid; Food, Formulated; Humans; Larva; Mammals; Metabolic Networks and Pathways; Methotrexate; Sulfaquinoxaline; Vitamin B 12	2015
Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents. Angewandte Chemie (International ed. in English), 2016, 12-23, Volume: 55, Issue:52 Topics: Boron Compounds; Colchicine; Erythrocytes; HeLa Cells; Humans; Methotrexate; Molecular Structure; Paclitaxel; Photochemical Processes; Vitamin B 12	2016
Effect of methotrexate/vitamin B Epigenomics, 2017, Volume: 9, Issue:9 Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Methylation; Humans; Long Interspersed Nucleotide Elements; Methotrexate; Neurons; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tacrolimus Binding Proteins; Vitamin B 12	2017
Bi-directional effects of vitamin B Scientific reports, 2017, 09-19, Volume: 7, Issue:1 Topics: Animals; Daphnia; DNA Methylation; Epigenesis, Genetic; Genome-Wide Association Study; Methotrexate; Reproduction; Vitamin B 12	2017
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2018, Volume: 67, Issue:8 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase; Tunisia; Vitamin B 12	2018
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia. PloS one, 2019, Volume: 14, Issue:9 Topics: Adolescent; Antidotes; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Infant; Leucovorin; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12	2019
Effects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinase. Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:12 Topics: Animals; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Male; Methotrexate; Rats; Rats, Wistar; Receptor-Interacting Protein Serine-Threonine Kinases; Treatment Outcome; Vitamin B 12	2020
Ascending myelopathy after intrathecal methotrexate. The Kaohsiung journal of medical sciences, 2021, Volume: 37, Issue:11 Topics: Adult; Antimetabolites, Antineoplastic; Bone Marrow Transplantation; Female; Humans; Injections, Spinal; Leucovorin; Leukemia, Myeloid, Acute; Magnetic Resonance Imaging; Methotrexate; Peripheral Blood Stem Cell Transplantation; Prednisone; Spinal Cord; Spinal Cord Diseases; Vitamin B 12	2021
Vitamin B12 suppresses Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2022, Volume: 97, Issue:4 Topics: Animals; Apoptosis; Male; Methotrexate; Rats; Rats, Wistar; Testis; Vitamin B 12	2022
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate. Zeitschrift fur Rheumatologie, 2023, Volume: 82, Issue:Suppl 1 Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; Vitamin B 12	2023
Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity. Journal of molecular histology, 2022, Volume: 53, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Catalase; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Kidney Diseases; Male; Malondialdehyde; Methotrexate; Rats; Rats, Wistar; Superoxide Dismutase; Vitamin B 12; Vitamin B Complex	2022