methotrexate has been researched along with thymidine in 436 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 361 (82.80) | 18.7374 |
| 1990's | 47 (10.78) | 18.2507 |
| 2000's | 21 (4.82) | 29.6817 |
| 2010's | 7 (1.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gangjee, A; Jain, HD; Kisliuk, RL; McGuire, JJ | 1 |
| Gangjee, A; Kisliuk, RL; Lin, X; McGuire, JJ | 1 |
| Akkemik, E; Budak, H; Ciftci, M | 1 |
| Kaminskas, E; Nussey, AC | 1 |
| Sutherland, GR | 1 |
| Raich, PC | 1 |
| Farmer, JL | 1 |
| Roberts, D; Warmath, EV | 1 |
| Forsdyke, DR; Scott, FW | 1 |
| Brunk, CF; Yaffe, D | 1 |
| Bogenhagen, D; Clayton, DA | 1 |
| Irvin, AD; Stagg, DA | 1 |
| Biermann, WA; Haurani, FI; Kardinal, CG | 1 |
| Jackson, RC | 2 |
| Schempp, W; Sigwarth, I; Vogel, W | 1 |
| Enomoto, T; Tanuma, S; Yamada, M | 1 |
| Heidelberger, C; Moran, RG; Mulkins, M | 1 |
| Jackson, RC; Weber, G | 1 |
| Marz, R; Plagemann, PG; Wohlhueter, RM | 1 |
| Balk, SD; Hoon, BS; LeStourgeon, D; Mitchell, RS | 1 |
| Harrap, KR; Straw, JA; Talbot, DC; Taylor, GA | 1 |
| Bertino, JR | 1 |
| Browman, GP; Harrap, KR; Taylor, GA | 1 |
| Shearer, M; Taylor-Papadimitriou, J; Watling, D | 1 |
| Grindey, GB; Pavelic, ZP; Semon, JH | 1 |
| Frei, E; Howell, SB; Krishan, A | 1 |
| Sauer, H; Schalhorn, A; Wilmanns, W | 2 |
| Friedman, MA; Sadée, W | 1 |
| Karasek, M; Liu, SC | 1 |
| Nakamura, N; Okada, S | 1 |
| Wyss, C | 1 |
| Ensminger, WD; Rosowsky, A | 1 |
| Grindey, GB; Kinahan, JJ; Otten, M | 1 |
| Van Der Weyden, MB | 1 |
| Abelson, HT; Beardsley, GP; McCaffrey, RP; Rosowsky, A | 1 |
| Akao, T; Fujimoto, S; Itoh, B; Itoh, K; Kitsukawa, Y; Takahashi, M | 1 |
| Marquet, J; Zittoun, J; Zittoun, R | 1 |
| Ensminger, WD; Frei, E; Howell, SB; Krishan, A | 1 |
| McCullough, JL; Newburger, AE; Weinstein, GD | 1 |
| Kaufmann, M; Kubli, F; Reus, W; Volm, M; von Fournier, D | 1 |
| Alexander, JA; Wheeler, GP | 1 |
| Grindey, GB; Semon, JH | 1 |
| Fry, DW; Goldman, ID; White, JC | 1 |
| de Loecker, W; van der Schueren, G | 1 |
| Cohen, A; Martin, DW; Ullman, B | 1 |
| Frei, E | 1 |
| Mueller, GC; Planck, SR | 1 |
| Fung, WP; Yang, KH; Zaharko, DS | 1 |
| Ensminger, WD; Frei, E | 1 |
| Sauer, H; Wilmanns, W | 1 |
| Goldman, ID | 1 |
| Hummel, H; Mattern, J; Volm, M | 1 |
| Boyle, JM; Fox, M | 1 |
| Frankfurt, OS; Goncharova, SA | 2 |
| Curt, GA; Kramer, RA; Parker, LM; Rosowsky, A; Tattersall, MH; Tobias, JS | 1 |
| Blakley, RL; Ho, YK; Hoffmann, CC; Thompson, JS | 1 |
| Lietman, PS; Rogers, HJ | 1 |
| Young, RC | 1 |
| Hryniuk, WM | 2 |
| Brox, LW; Henderson, JF; Hryniuk, WM; Tamaoki, T | 1 |
| Ferguson, RJ; McMaster, JH; Weinert, CR | 1 |
| Karle, H; Killmann, SA; Wantzin, GL | 1 |
| Brown, B; Frei, E; Tattersall, MH | 1 |
| Frei, E; Jaffe, N; Parker, L; Pitman, S; Tattersall, MH | 1 |
| Håkansson, L | 1 |
| Brown, BL; Frei, E; Tattersall, MH | 1 |
| MacManus, JP; Youdale, T | 1 |
| Greenberg, ML; Waxman, S | 1 |
| Bull, JM; Chabner, BA; Pinedo, HM; Zaharko, DS | 1 |
| Azizkhan, JC; Speeg, KV; Stromberg, K | 1 |
| Langley, D; Pritchard, MA; Rittenberg, S | 1 |
| Bergsagel, DE; Librach, SL; Ogawa, M | 1 |
| McCullough, JL; Weinstein, GD | 1 |
| Grindey, GB; Moran, RG | 1 |
| Dahn, I; Håkansson, L; Huldt, B | 1 |
| Maisenbacher, J; Probst, H | 1 |
| Berg, T; Johnsen, SR; Melbye, B; Prydz, H | 1 |
| Rasmussen, L; Zeuthen, E | 1 |
| Arlett, CF; Cole, J | 1 |
| DeLapp, NW; Karasek, MA | 1 |
| Fujieda, S; Ohtsubo, T; Saito, H; Tanigawa, N | 1 |
| Freisheim, JH; Jansen, G; McAlinden, TP; Prasad, KM; Ratnam, M; Schornagel, JH; Westerhof, GR; Williams, FE | 1 |
| Aran, JM; Plagemann, PG | 1 |
| Arredondo, MA; Guimaraes, MA; Rustum, YM; Yin, MB; Zhang, ZG | 1 |
| Bjerknes, R; Haaskjold, E; Refsum, H; Refsum, SB | 1 |
| Chaabouni, H; Hila, L | 1 |
| Barrios, L; Egozcue, J; Fuster, C; Miró, R | 1 |
| Grem, JL | 1 |
| Taniki, T; Weber, G; Zhen, YS | 1 |
| Atillasoy, ES; Barnett, SK; Milstone, LM; Schwartz, PM | 1 |
| Matsuo, Y; Minowada, J; Otani, T; Sur, P | 2 |
| Cao, S; Wu, S; Xue, Y; Zhen, Y | 1 |
| Christian, MC; Grem, JL; King, SA; Sorensen, JM | 1 |
| Christensen, B; Djurhuus, R; Refsum, H; Ueland, PM | 1 |
| Gutjahr, P; Reitz, M | 1 |
| Belt, JA; Crawford, CR; Ng, CY | 1 |
| Nagai, M; Nakamura, H; Olah, E; Prajda, N; Szekeres, T; Weber, G | 1 |
| Chan, TC; Howell, SB | 1 |
| Alarcòn, GS; Baggott, JE; Everson, MP; Hardin, JM; Hine, RJ; Koopman, WJ; Krumdieck, CL; Morgan, SL | 1 |
| Bakker, MA; Bökkerink, JP; Damen, FJ; De Abreu, RA; Hulscher, MW | 1 |
| Ichikawa, S; Nagai, M; Natsumeda, Y; Weber, G | 1 |
| Booker, L; Browman, GP; Spiegl, P | 1 |
| Kane, MA; Raptis, G; Roth, E; Schreiber, C; Waxman, S | 1 |
| Milstone, LM; Schwartz, PM | 1 |
| Akiyama, Y; Kiriyama, Y; Kito, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 2 |
| Fischer, PH; Kunugi, K; Vazquez-Padua, MA | 1 |
| Chabner, BA; Curt, GA; Fine, RL; Griffin, JD; Koizumi, S | 1 |
| Friedman, SJ; Green, BJ; Hoar, DI; Inoue, M; Matheson, DS | 1 |
| Bertino, JR; Sobrero, AF | 1 |
| Baker, E; Eichenbaum, SZ; Hockey, A; Krumins, E; Purvis-Smith, S; Sutherland, GR | 1 |
| Branda, RF; Carney, JK; McCormack, JJ; Moore, AL; Perlmutter, CA | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Houghton, JA; Houghton, PJ; Meyer, WH | 1 |
| Benedict, WF; Heidelberger, C; Peterson, AR | 1 |
| Bertino, JR; Handschumacher, RE; Sobrero, AF | 1 |
| Hoth, DF; King, SA; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Iseki, T; Iwasa, S; Kanazawa, S; Kondo, H; Okuda, K | 1 |
| Boiocchi, M; Broggini, M; D'Incalci, M; Erba, E; Lorico, A; Rappa, G; Toffoli, G | 1 |
| deFazio, A; Hughes, JM; Tattersall, MH | 1 |
| Beverley, SM; Peixoto, MP | 1 |
| Hayashi, M; Honma, Y; Hozumi, M; Okabe-Kado, J | 1 |
| Burres, NS; Cass, CE | 1 |
| Diddens, H; Niethammer, D; Teufel, T | 1 |
| Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Ledbetter, DH; Nussbaum, RL | 1 |
| Glait, HM; Horenstein, AL; Koss, A | 1 |
| Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK | 1 |
| Mroczka, D; Nelson, JA | 1 |
| Choy, YM; Fung, KP; Lam, WP; Ng, SW | 1 |
| Meyer, JS | 1 |
| Choy, YM; Fung, KP; Ng, SW | 1 |
| Chwalinski, S; Potten, CS | 1 |
| Fischer, PH; Reznikoff, CA; Vazquez-Padua, MA | 1 |
| Iland, HJ; Laszlo, J; Sedwick, WD | 1 |
| Ayusawa, D; Hori, T; Koyama, H; Seno, T; Shimizu, K; Takeishi, K | 1 |
| Nicander, B; Reichard, P | 1 |
| Plagemann, PG; Wohlhueter, RM | 1 |
| Fitzgerald, PH; Morris, CM | 1 |
| Kaiho, T; Sekiya, S; Takamizawa, H | 1 |
| Kidwell, WR | 1 |
| Goerttler, K; Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Adams, JE; Martin, WE; Pomerat, CM | 1 |
| Eder, M | 1 |
| Seidel, HJ; Wegner, LA | 1 |
| Wüst, GP | 1 |
| Matthes, KJ; Wüst, GP | 1 |
| Boden, B; Fünfhausen, G; Stinner, G | 1 |
| Hirsiger, H; Schaer, JC; Schindler, R; Siegers, MP | 1 |
| Jungkind, DL; Wood, RC | 2 |
| Eker, P | 2 |
| Lang, A; Nitsan, J | 2 |
| Canellos, GP; Greenberg, NH; Mead, JA; Schrecker, AW | 1 |
| Foley, GE; Lazarus, H | 1 |
| Grossowicz, N; Mandelbaum-Shavit, F | 2 |
| Kolb, B; Ramseier, L; Schindler, R | 1 |
| Hoshino, T; Nagai, M; Sano, K | 1 |
| Steffen, JA; Stolzmann, WM | 1 |
| Kustova, OV; Lomakina, LIa | 1 |
| Ockey, CH; Williams, CA | 1 |
| Fukui, K; Halprin, K; Marks, R | 1 |
| Kummer, D | 1 |
| Fox, M; Nias, AH | 1 |
| Ockey, CH | 1 |
| Makulu, DR | 1 |
| Zeuthen, E | 3 |
| Halterman, RH; Herberman, RB; Leventhal, BG; McCoy, JL; Rosenberg, EB | 1 |
| Erickson, V; Graham, TC; Kolb, H; Kolb, HJ; Lerner, KG; Mickelson, E; Rudolph, RH; Storb, R; Thomas, ED | 1 |
| Prescott, DM; Wise, GE | 1 |
| Forsdyke, DR; Sjostrom, DA | 1 |
| Sprecher-Goldberger, S | 1 |
| Baluda, MA; Brodetsky, AM; Knudson, AG | 1 |
| Bowman, RL; Braslow, NM | 1 |
| Mundinger, F | 1 |
| Catovsky, D; Das, KC; Hoffbrand, V; Tripp, E | 1 |
| Sneider, TW | 1 |
| Bluming, AZ; Fass, L; Iversen, OH; Morrow, RH; Ziegler, JL | 1 |
| Balazs, I; Brown, EH; Schildkraut, CL | 1 |
| Hansen, HH; Krezoski, SK; Muggia, FM | 1 |
| Altaner, C; Hladká, M | 1 |
| Calabresi, P; Fischer, GA; Lee, SY | 1 |
| Bykovskaya, SN; Kadagidze, ZG; Slavina, EG | 1 |
| Bull, FE; Ruddon, RW; Wheeler, RH | 1 |
| Donsbach, RC; Sirotnak, FM | 1 |
| Muckle, DS | 1 |
| Galt, RM; Knock, FE; Oester, YT; Sylvester, R | 1 |
| Chary, KK; Humphrey, GB; Krivit, W; Nesbit, ME | 1 |
| Lampkin, BC; Mauer, AM; McWilliams, NB | 2 |
| Gallo, RC; Levine, P; Smith, RG; Ting, RC; Whang-Peng, J | 1 |
| Bakkeren, JA; de Vaan, GA; Schretlen, ED | 1 |
| Evert, CF; Lampkin, BC; Mauer, AM; McWilliams, NB | 1 |
| Ernst, P | 1 |
| Furness, ME; Goldie, JH; Price, LA | 1 |
| Borella, L; Green, AA | 1 |
| Berry, CL; Germain, J | 1 |
| Harrap, KR; Tattersall, MH | 1 |
| Cooper, LE; Groth, DP; Vogler, WR | 1 |
| Bishop, A; Foerster, J; Hryniuk, WM | 1 |
| McBurney, MW; Whitmore, GF | 1 |
| Harrap, KR; Jackson, RC; Jackson, ST; Tattersall, MH | 1 |
| Lampkin, BC; Mauer, AM | 1 |
| DaCosta, M; Kamen, B; Rothenberg, SP | 1 |
| Blackett, NM; Constable, TB | 1 |
| Dunn, CD | 1 |
| Lipkin, M; Troncale, FJ | 1 |
| Thomas, DW | 1 |
| Weinstein, WM | 1 |
| Andersen, V; Killmann, SA; Weeke, E | 1 |
| Jeffery, WR | 1 |
| Andersen, HA | 2 |
| Muzik, H; Paterson, AR; Warnick, CT | 1 |
| Hussa, RO; Pattillo, RA | 1 |
| Edlis, H; Herbert, V; Tisman, G | 1 |
| Bagai, RC; Harris, JE; Stewart, TH | 1 |
| Chabner, BA; Young, RC | 1 |
| Hermanová, E; Pristoupilová, K; Slavík, K | 1 |
| Cox, RP; Malathi, VG; Meyers, R; Silber, R | 1 |
| Comings, DE; Okada, TA | 1 |
| Rizki, RM; Rizki, TM | 1 |
| Jasińska, JK; Steffen, JA; Swierkowska, KM | 1 |
| Ernst, P; Killmann, SA | 4 |
| Byfield, JE; Karlsson, U | 1 |
| Radnay, J; Rozenszajn, LA | 1 |
| Killmann, SA | 1 |
| Beer, CT; Kajiwara, K; Mueller, GC | 1 |
| Altmann, GG | 1 |
| Auletta, AE; Davis, J; Gery, AM; Mead, JA; Mishra, L; Parmar, A | 1 |
| Benassi, M; Bresciani, F; Casale, C; Nervi, C; Paoluzi, R; Ziparo, E | 1 |
| Mattern, J; Volm, M; Wayss, K | 1 |
| Benckhuijsen, C | 1 |
| Borsa, J; Whitmore, GF | 3 |
| Buckner, CD; Clift, RA; Epstein, RB; Rudolph, RH; Storb, R; Thomas, ED | 1 |
| Roberts, D | 1 |
| Adachi, M; Fujimoto, S; Miyoshi, T; Urushibara, O; Watanabe, Y | 1 |
| Salen, G; Schumacher, HR | 1 |
| Gautschi, JR; Hürni, C; Schindler, R | 1 |
| Firkin, B; Rother, M; Van der Weyden, M | 1 |
| Green, R; Metz, J; Sive, J | 1 |
| Hoffman, J; Post, J | 1 |
| Bach, JF; Bach, MA | 1 |
| Velasco, J; Weinstein, GD | 1 |
| Bernheim, NJ; Clive, D; Flamm, WG; Machesko, MR | 1 |
| Alesenko, AV; Burlakova, EB; Waĭnson, AA | 1 |
| Shapiro, WR | 1 |
| Blunt, RJ; Jones, R | 1 |
| Calman, N; Eng, B; Slater, LM; Wallerstein, H | 1 |
| White, JE | 2 |
| Margolis, S; Philips, FS; Sternberg, SS | 1 |
| Di Rosa, M; Papadimitriou, JM; Willoughby, DA | 1 |
| Fox, M | 1 |
| Frost, P; Nyhan, WL; Shear, CS; Weinstein, GD | 1 |
| Hall, TC; Roberts, D | 1 |
| Kajiwara, K; Mueller, GC; Spalding, J | 1 |
| Hall, TC; Roberts, D; Rosenthal, D | 1 |
| Bertino, JR; Hryniuk, WM | 2 |
| Cooper, EH; Gabutti, V; Gavosto, F; Pileri, A; Tarocco, RP | 1 |
| Delalieux, G; Manaster, J; Socquet, M; Stryckmans, P | 1 |
| Hartje, J; Wilmanns, W | 1 |
| Lampkin, BC; Mauer, AM; Nagao, T | 1 |
| Weinstein, GD | 1 |
| Bertino, JR; Capizzi, R; Hryniuk, WM | 1 |
| Eder, M; Rostock, H; Vogel, G | 1 |
| Bertino, JR; McCullough, JL; O'Brien, P | 1 |
| Hakala, MT | 1 |
| Loehr, EV; Roberts, D | 1 |
| Frost, P; Weinstein, GD | 1 |
| Brinkmann, W; Dörmer, P; Muschalik, P | 2 |
| Bertino, JR; Fischer, GA; Hryniuk, WM | 1 |
| Friedman, DL | 1 |
| Groundwater, JR; Maibach, HI | 1 |
| Villadsen, IS; Zeuthen, E | 1 |
| Jasińska, J; Michalowski, A; Steffen, JA | 1 |
| Hampton, EG | 1 |
| Margolis, LB | 1 |
| Benzio, G; Bernengo, MG; Pegoraro, L | 1 |
| Fujimoto, S; Miyoshi, T; Watanabe, Y; Watanuki, S | 1 |
| Coward, JE; Gentry, GA; Morse, PA | 1 |
| Comings, DE; Kakefuda, T | 1 |
| Chu, MY; Fischer, GA | 1 |
| Grieder, A; Odartchenko, N; Ramseier, L; Schindler, R | 1 |
| Burnett, JP; Dwyer, AC; Harrington, JA; Summers, AO | 1 |
| Blackett, NM | 1 |
| Roberts, D; Wodinsky, I | 1 |
| Herbert, V; Metz, J; Waxman, S | 1 |
| Labow, R; Maley, F; Maley, GF | 1 |
| Herbert, V; Waxman, S | 1 |
| Hsu, TC; Humphrey, RM | 1 |
| Almquist, P; Bertino, JR; Evans, EA; Hollingsworth, JW; Johns, DG | 1 |
| Gerschenson, LE; Rounds, DE; Strasser, FF | 1 |
| Evans, EA | 1 |
| Damm, H; Desprez, JD; Kiehn, CL; Krizek, TJ | 1 |
| Ozer, HL | 1 |
| Cohen, LS; Roseman, J; Schweitzer, JL; Studzinski, GP | 1 |
| Bruce, WR | 1 |
| Galivan, J | 1 |
| Tattersall, MH; Taylor, IW | 1 |
| Singer, R; Weidauer, H | 1 |
| Lankelma, J; Leyva, A; Nederbragt, H; Pinedo, HM | 1 |
| Beaulieu, D; Matiaszuk, NV; Pottier, A; Rosenblatt, DS; Vuchich, MJ; Whitehead, VM | 1 |
| Ellims, PH | 1 |
| Rosenblatt, DS; Whitehead, VM | 1 |
| Benz, C; Cadman, E; Choti, M; Newcomer, L | 1 |
| Keiding, N; Larsen, JK; Møller, U | 1 |
| Burry, RW | 1 |
| Kimura, K; Tanaka, M; Yoshida, S | 1 |
| Bernheim, JL; Naaktgeboren, N; Roobol, K; Theunissen, J | 1 |
| Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ | 1 |
| Howell, SB; Mansfield, SJ; Taetle, R | 2 |
| Powis, G | 1 |
| Shapiro, WR; Young, DF | 1 |
| Beck, WS; Pelliniemi, TT | 1 |
| Ayusawa, D; Koyama, H; Seno, T | 1 |
| Ali-Osman, F; Maurer, HR | 1 |
| Leyva, A; Pinedo, HM; Schornagel, JH; Uitendaal, MP | 2 |
| Bover, L; Cabral, S; Leis, S; Mordoh, J; Nembrot, M | 1 |
| Ochi, T; Ohsawa, M; Takahashi, K | 1 |
| Abelson, HT; Beardsley, GP; Fosburg, MT; Goorin, AM; Gorka, C; Link, D; Link, M | 1 |
| Samuels, LL; Straw, JA | 1 |
| Hamlin, JL; Heintz, NH | 1 |
| Mackinnon, WB; Nott, SE; Piper, AA; Tattersall, MH | 1 |
| Green, B; Hoar, DI; Matheson, DS | 1 |
| Shimizu, T | 1 |
| Leyva, A; Pinedo, HM; Schornagel, JH | 2 |
| Yunis, JJ | 1 |
| Das, KC; Garewal, G; Mohanty, D | 1 |
| Alonso, A; Barriga, C; de la Fuente, M; Peña, J | 1 |
| Tschiersch, B | 1 |
| Halprin, KM; Levine, V; Taylor, JR; Woodyard, C | 1 |
| Tattersall, MH | 1 |
| Chacón, RD; Filmus, J; Mordoh, J | 1 |
| Leyva, A; Nederbragt, H; Pinedo, HM; Uitendaal, MP; van der Grint, L | 1 |
| Bogyo, D; Mihich, E | 1 |
| Browman, GP; Calvert, AH; Harrap, KR; Hart, LI; Taylor, GA | 1 |
| Ariel, M; Grossowicz, N; Holtzer, E; Lavi, H | 1 |
| Bruno, S; Creaven, P; Grindey, G; Kinahan, J; Ledesma, E; Mittelman, A; Moayeri, H; Priore, R; Zakrzewski, S | 1 |
| Browman, GP | 1 |
| Martin, DS; Nayak, R; Sawyer, RC; Spiegelman, S; Stolfi, RL; Woodcock, T; Young, CW | 1 |
| Sauer, H; Schalhorn, A | 1 |
| Brennand, J; Fox, M; Saffhill, R | 1 |
| Iwata, N; Maekawa, T; Omine, M; Yamauchi, H | 1 |
| Tisdale, MJ | 1 |
| Browman, GP; Csullog, GW | 1 |
| Clarke, R; Murphy, RF; Van den Berg, HW | 1 |
| Dove, WF; Laffler, TG | 1 |
| Howell, SB; Tamerius, RK | 1 |
| Ayusawa, D; Iwata, K; Koyama, H; Seno, T | 1 |
| Calvert, AH; Dady, PJ; Harrap, KR; Muindi, JF; Smith, IE; Smyth, JF; Taylor, GA | 1 |
| Laszlo, J; Sedwick, WD | 1 |
| Boss, GR; Frei, E; Herbst, K; Howell, SB | 1 |
| Lin, HS | 1 |
| Fernandes-Costa, F; Metz, J; Miller, H | 1 |
| Henson, E; McClarty, G; Wang, LL | 1 |
| Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ | 1 |
| Baker, CJ; Camacho, M; Haber, M; Kavallaris, M; Madafiglio, J; Norris, MD; Stewart, BW; White, L | 1 |
| Iizuka, H; Takagi, A | 1 |
| Andreola, S; Benini, E; Brambilla, C; Daidone, MG; Ferrari, L; Greco, M; Luisi, A; Mastore, M; Silvestrini, R; Veneroni, S | 1 |
| Hu, JL; Qi, CQ; Su, J; Zhen, YC | 1 |
| Gimsing, P; Hippe, E | 1 |
| Egan, MG; Garrow, TA; Rumberger, BG; Shane, B; Sirlin, S; Sirotnak, FM | 1 |
| Banks, SD; Barrett, LL; Dickerson, S; Pendergast, W; Smith, GK; Waters, KA | 1 |
| Kremer, JM | 1 |
| Lehman, NL; Moran, RG; Smith, SG | 1 |
| Baumgart, F; Köpf-Maier, P; Tausch-Treml, R; Ziessow, D | 1 |
| Christensen, IJ; Christensen, J; Larsen, JK; Møller, U | 1 |
| Baldini, E; Bevilacqua, G; Collecchi, P; Conte, PF; Giannessi, PG; Naccarato, AG; Passoni, A | 1 |
| Anderson, M; Chu, E; Dearing, MP; Englee-Miller, MJ; Gazdar, AF; Kramer, BS; Kratzke, RA; Mulshine, JL; Venzon, D; Weinstein, J | 1 |
| Amadori, A; Amadori, D; Amaducci, L; Giunchi, DC; Maltoni, R; Nanni, O; Saragoni, A; Silvestrini, R; Vio, A; Volpi, A | 1 |
| Adamson, PC; Balis, FM; Montello, MJ; Murphy, RF; O'Brien, M; Sorensen, JM; Widemann, BC | 1 |
| Cheng, RZ; Li, J; Shammas, MA; Shmookler Reis, RJ | 1 |
| Blakley, RL; Lewis, WS; Mareya, SM; Patel, M; Sleep, SE; Sorrentino, BP; Spencer, HT | 1 |
| Bervoets, TJ; Bronckers, AL; Lyaruu, DM; van Duin, MA; Wöltgens, JH | 1 |
| Chow, M; Koo, J; Ng, P; Rubin, H | 1 |
| Kim, C; Lee, KJ; Park, JE | 1 |
| Antony, AC; Gharehbaghi, K; Jayaram, HN; Li, QJ; Sun, XL; Xiao, X | 1 |
| Canestrari, JG; McGuire, JJ; Nagel, GS | 1 |
| Barnes, MJ; Newell, DR; Taylor, GA | 1 |
| Genestier, L; Izeradjene, K; Revillard, JP | 1 |
| Grosse-Wilde, H; Jacob, JR; Kreuzfelder, E; Maschke, J; Menne, S; Roggendorf, M; Tennant, BC | 1 |
| Beijnen, JH; Boogerd, W; Mathĵt, RA; Schellens, JH; Schornagel, JH; Soesan, M; van den Bongard, HJ | 1 |
| Aggarwal, BB; Majumdar, S | 1 |
| Drouin, R; Lavoie, J | 1 |
| Fagny, C; Robberecht, P; Svoboda, M; Vandevelde, M | 1 |
| Cole, PD; Kamen, BA; Smith, AK | 1 |
| SCHINDLER, R | 1 |
| MILLER, E; SULLIVAN, RD | 1 |
| SCHINKLER, R | 1 |
| TEMIN, HM | 1 |
| CASTELLS, J; MESCHAN, I | 1 |
| BENSON, JW; DAMM, H; DESPREZ, JD; KIEHN, CL | 1 |
| GENTRY, GA; LAWSON, LA; RANDALL, CC | 1 |
| MORSE, PA; POTTER, VR | 1 |
| GEBERT, R; GENTRY, GA; IVES, DH; MORSE, PA; POTTER, VR | 1 |
| HODAS, S; YOUNG, CW | 1 |
| Bornmann, W; Koutcher, JA; Rubio, MB; Spees, WM; Veach, D; Yang, G | 1 |
| Castro, M | 1 |
| Banerjee, D; Bertino, JR; Li, WW; Magro, PG; Russo, AJ | 1 |
| Abbeyquaye, T; Chen, CY; Chu, M; Guo, J | 1 |
| Belt, JA; Marina, NM | 1 |
| Aramaki, H; Fukagawa, T; Higuchi, S; Ichimiya, T; Inoue, K; Koyanagi, S; Matsunaga, N; Ohdo, S; Taguchi, Y; Yamauchi, A | 1 |
| Bertrandy, S; Delanoue, R; Dutriaux, A; Flagiello, D; Legent, K; Mas, M; Piskur, J; Silber, J | 1 |
| Barrett, DA; Fouladi-Nashta, AA; Halliday, N; Li, D; Sinclair, KD; Singh, R | 1 |
| Beijnen, JH; Schellens, JH | 1 |
| Altinoz, MA; Bilir, A; Del Maestro, RF; Gedikoglu, G; Ozcan, E; Ozdilli, K; Sav, A | 1 |
| Nelson, LS; Smith, SW | 1 |
| Dong, L; He, XD; Hu, SL; Li, M; Shen, ZJ; Tao, SN; Zhu, YY | 1 |
| Anderson, RJ; Cunningham, A; Donaldson, M; George, SE; Groundwater, PW | 1 |
| Adamson, PC; Balis, FM; Boron, M; Cole, DE; Eby, M; Fox, E; Ivy, P; Jayaprakash, N; Kim, A; Murphy, RF; O'Brien, M; Shalabi, A; Widemann, BC | 1 |
| Banerjee, D; Bertino, JR; Blasberg, RG; Cai, S; de Stanchina, E; Kochetkov, T; Moroz, MA; Nair, J; Schwartz, GK; Serganova, I; Shamis, M; Wu, J | 1 |
| Baharav, E; Bar, M; Gil-Ad, I; Karp, L; Taler, M; Weinberger, A; Weizman, A | 1 |
| Bhinder, B; Djaballah, H; Fischer, MA; Früh, K; Hirsch, AJ; Nelson, JA; Parkins, C; Radu, C; Shum, D; Smith, JL; Stein, DA | 1 |
| Harada, R; Kawami, M; Ojima, T; Takano, M; Yamagami, Y; Yumoto, R | 1 |
23 review(s) available for methotrexate and thymidine
| Article | Year |
|---|---|
The fluoropyrimidines: biochemical mechanisms and design of clinical trials.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Metabolism; Methotrexate; Pyrimidines; Thymidine; Thymine | 1978 |
Methotrexate revisited.
Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Kidney; Kidney Failure, Chronic; Leucovorin; Leukemia L1210; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Thymidine; Vincristine | 1976 |
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
Topics: Colonic Neoplasms; Deoxyuridine; Dipyridamole; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Nucleosides; Nucleotides; RNA, Neoplasm; Thymidine; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Clinical use of thymidine as a rescue agent from methotrexate toxicity.
Topics: Adolescent; Adult; Aged; Child; Female; Humans; Kidney; Kidney Diseases; Male; Meta-Analysis as Topic; Methotrexate; Middle Aged; Thymidine | 1991 |
Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Cytidine; Deoxycytidine; Deoxyribonucleotides; DNA; Embryo, Mammalian; Fibroblasts; Floxuridine; Fluorouracil; Idoxuridine; Methotrexate; Mice; Mice, Inbred C3H; Mutation; Thymidine; Trifluridine | 1985 |
Role of thymidine in biochemical modulation: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Deoxycytidine Kinase; DNA Replication; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Interphase; Kinetics; Leukemia; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acid Synthesis Inhibitors; Nucleotides; Phosphonoacetic Acid; RNA, Neoplasm; Species Specificity; Thymidine | 1987 |
Biochemical modulation: application of laboratory models to the clinic.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Dose-Response Relationship, Drug; Drug Evaluation; Fluorouracil; Humans; Methotrexate; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Thymidine | 1986 |
Fragile X syndrome: a unique mutation in man.
Topics: Caffeine; Chromosome Fragility; Female; Fragile X Syndrome; Genetic Counseling; Genetic Linkage; Genetic Markers; Heterozygote; Humans; Hybrid Cells; Intellectual Disability; Male; Methotrexate; Models, Genetic; Pedigree; Phenotype; Sex Chromosome Aberrations; Thymidine | 1986 |
Thymineless death and genetic events in mammalian cells.
Topics: Animals; Cell Survival; Centrifugation, Density Gradient; Chromosome Aberrations; Cycloheximide; Dactinomycin; DNA; DNA Replication; Humans; Interphase; Methotrexate; Methyltransferases; Mice; Mitosis; Mutation; Recombination, Genetic; Sister Chromatid Exchange; Thymidine; Thymidine Monophosphate; Thymidylate Synthase; Ultrafiltration | 1985 |
Synchronization of mammalian cells with respect to the mitotic cycle.
Topics: Animals; Antineoplastic Agents; Autoradiography; Calcium; Carbon Isotopes; Cattle; Cell Count; Cell Differentiation; Cell Line; Cells; Cells, Cultured; Centrifugation, Density Gradient; Clone Cells; Cold Temperature; Cricetinae; Culture Techniques; DNA; Female; Floxuridine; Guinea Pigs; HeLa Cells; Humans; Hydroxyurea; Iodine Isotopes; Kinetics; L Cells; Liver; Methods; Methotrexate; Mice; Mitosis; Ovary; RNA; Statistics as Topic; Thymidine; Time Factors; Tritium | 1971 |
Synchronization of the Tetrahymena cell cycle.
Topics: Animals; Antimalarials; Carbon Isotopes; Cell Division; Cell Nucleus; Culture Media; DNA; DNA Replication; Floxuridine; Hot Temperature; Methotrexate; Morphogenesis; Nucleosides; Protein Biosynthesis; Temperature; Tetrahymena; Tetrahymena pyriformis; Thymidine; Time Factors; Transcription, Genetic; Tritium; Uridine | 1971 |
The cell cycle and the development of pathology in the gastrointestinal tract.
Topics: Adenine; Animals; Autoradiography; Cell Count; Cell Division; Colon; Digestive System; DNA; Flucytosine; Fluorouracil; Humans; Intestine, Small; Methotrexate; Pentosyltransferases; RNA; Stomach; Thymidine; Thymidine Kinase; Tritium | 1972 |
Epithelial cell renewal of the small intestinal mucosa.
Topics: Celiac Disease; Cell Differentiation; Cell Division; Cell Movement; Colchicine; Cytological Techniques; Epithelial Cells; Epithelium; Folic Acid Deficiency; Humans; Intestinal Mucosa; Intestine, Small; Malabsorption Syndromes; Methotrexate; Mitosis; Radiation Effects; Thymidine; Time Factors; Tritium; Vitamin B 12 Deficiency | 1974 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; Hydroxyurea; In Vitro Techniques; Leukemia; Leukemia L1210; Leukemia, Lymphoid; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitosis; Nitroso Compounds; Prednisone; Thymidine; Time Factors; Tritium; Vinblastine; Vincristine | 1969 |
In search of a key.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cricetinae; DNA, Neoplasm; Drug Combinations; Humans; In Vitro Techniques; Leukemia; Leukemia, Experimental; Leukocytes; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1971 |
[Results of primary antineoplastic chemotherapy in advanced keratinizing squamous epithelial carcinomas of the head and neck region].
Topics: Adult; Aged; Bleomycin; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Inosine; Leucovorin; Male; Methotrexate; Middle Aged; Prognosis; Thymidine; Vincristine | 1981 |
Thymidine as an anticancer agent, alone or in combination. A biochemical appraisal.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Neoplasms; Thymidine | 1982 |
Dose-dependent metabolism, therapeutic effect, and toxicity of anticancer drugs in man.
Topics: Alanine; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Ifosfamide; Kinetics; Methotrexate; Thymidine | 1983 |
Neurological complications of antineoplastic therapy.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Aspartic Acid; Cisplatin; Cytarabine; Fluorouracil; Humans; Methotrexate; Nervous System Diseases; Phosphonoacetic Acid; Thymidine; Vinblastine; Vincristine | 1984 |
Is there a role for thymidine in cancer chemotherapy?
Topics: Cytarabine; Drug Therapy, Combination; Fluorouracil; Humans; Kinetics; Leukemia; Methotrexate; Neoplasms; Thymidine | 1982 |
[Metabolic modulation as a method in tumor chemotherapy].
Topics: Antineoplastic Agents; Cytarabine; Fluorouracil; Humans; Methotrexate; Neoplasms; Tegafur; Thymidine; Uracil | 1982 |
An overview of thymidine.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Methylthioinosine; Mice; Neoplasms; Thymidine | 1980 |
The mechanism of action of methotrexate in rheumatoid arthritis: the search continues.
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Humans; Leukotriene Antagonists; Lipoxygenase Inhibitors; Methotrexate; Thymidine | 1994 |
7 trial(s) available for methotrexate and thymidine
| Article | Year |
|---|---|
Sequential therapy compared with combination therapy in multiple myeloma.
Topics: Autoradiography; Bence Jones Protein; Bone Neoplasms; Cell Count; Drug Therapy, Combination; Humans; Immunoglobulins; Kinetics; Melphalan; Methotrexate; Mitosis; Multiple Myeloma; Plasma Cells; Prednisone; Risk; Thymidine; Time Factors; Tritium; Vincristine | 1975 |
Extracorporeal irradiation of the blood: clinical applications.
Topics: Blood Cells; Cesium Isotopes; Clinical Trials as Topic; Cobalt Radioisotopes; Cytidine; Erythrocytes; Extracorporeal Circulation; Hematocrit; Humans; Immunosuppression Therapy; Isotope Labeling; Kinetics; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocytes; Methotrexate; Radiation Effects; Radioisotope Teletherapy; Radioisotopes; Radiotherapy Dosage; Reticulocytes; Strontium Radioisotopes; Thymidine; Tritium; Yttrium Isotopes | 1974 |
Studies on preoperative cancer chemotherapy. Effects of preoperative intra-arterial infusion of methotrexate and mitomycin C on stomach cancer.
Topics: Adult; Aged; Biopsy; Clinical Trials as Topic; Culture Techniques; Female; Humans; Injections, Intra-Arterial; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Mitomycins; Peptic Ulcer; Pyridoxal Phosphate; Stomach Neoplasms; Thymidine; Tritium | 1971 |
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Head and Neck Neoplasms; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Purines; Random Allocation; Thymidine | 1983 |
An overview of thymidine.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Methylthioinosine; Mice; Neoplasms; Thymidine | 1980 |
Changes in biological markers after primary chemotherapy for breast cancers.
Topics: Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Breast Neoplasms; Cell Cycle; Cell Division; Cyclophosphamide; Diploidy; DNA, Neoplasm; Doxorubicin; Epirubicin; Female; Fluorouracil; Humans; Methotrexate; Mitoxantrone; Neoplasm Staging; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; S Phase; Thymidine; Tumor Suppressor Protein p53 | 1995 |
Effects of primary chemotherapy on biological parameters of locally advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Cisplatin; Cyclophosphamide; Epirubicin; Evaluation Studies as Topic; Female; Fluorouracil; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Methotrexate; Middle Aged; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor, IGF Type 1; Thymidine; Treatment Outcome; Tritium | 1996 |
407 other study(ies) available for methotrexate and thymidine
| Article | Year |
|---|---|
Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Pyrimidines; Structure-Activity Relationship; Thymidylate Synthase | 2004 |
Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofol
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Escherichia coli; Folic Acid Antagonists; Glutamates; Humans; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma | 2005 |
Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study.
Topics: Adult; Binding, Competitive; Enzyme Inhibitors; Erythrocytes; Glucosephosphate Dehydrogenase; Humans; Kinetics; Male; Pentose Phosphate Pathway; Sulfur Compounds | 2010 |
Effects of methotrexate and of environmental factors on glycolysis and metabolic energy state in cultured Ehrlich ascites carcinoma cells.
Topics: Adenine Nucleotides; Amino Acids; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Culture Media; Cycloheximide; Dactinomycin; Energy Metabolism; Glucose; Glycolysis; Hydrogen-Ion Concentration; Hypoxanthines; Methotrexate; Phosphates; Thymidine | 1978 |
Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Culture Media; Dose-Response Relationship, Drug; Folic Acid; Humans; Hydrogen-Ion Concentration; Lymphocytes; Methotrexate; Phenotype; Thymidine; Time Factors | 1979 |
Prediction of therapeutic response in acute leukaemia.
Topics: Adult; Aged; Cells, Cultured; Cyclophosphamide; Cytarabine; Depression, Chemical; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis; Remission, Spontaneous; Thymidine; Tritium; Vincristine | 1978 |
Conditional antifolate resistance in Bacillus subtilis thyA.
Topics: Bacillus subtilis; Drug Resistance, Microbial; Folic Acid Antagonists; Kinetics; Methotrexate; Mutation; Tetrahydrofolate Dehydrogenase; Thymidine; Transformation, Bacterial | 1979 |
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine | 1975 |
Isotope-dilution studies of the effects of 5-fluorodeoxyuridine and hydroxyurea on the incorporation of deoxycytidine and thymidine by cultured thymus cells.
Topics: Animals; Cells, Cultured; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; DNA Replication; Floxuridine; Hydroxyurea; Methotrexate; Rats; Thymidine; Thymus Gland | 1976 |
The reversible inhibition of myoblast fusion by ethidium bromide (EB).
Topics: Cell Fusion; Cells, Cultured; Chloramphenicol; Cytarabine; DNA; Dose-Response Relationship, Drug; Ethidium; Floxuridine; Hydroxyurea; Methotrexate; Protein Biosynthesis; Rifampin; RNA; Thymidine | 1976 |
Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cells.
Topics: Animals; Bromodeoxyuridine; Cell Nucleus; DNA, Mitochondrial; Floxuridine; L Cells; Methotrexate; Mice; Phosphates; Thymidine; Thymidine Kinase | 1976 |
Theileria parva: purine and pyrimidine metabolism and the action of folate antagonists in parasitized bovine lymphoid cells.
Topics: Adenine; Aminopterin; Animals; Azaguanine; Cattle; Cells, Cultured; Culture Media; Eukaryota; Floxuridine; Folic Acid Antagonists; Guanine; Hypoxanthines; Lymphocytes; Methotrexate; Purines; Pyrimidine Nucleosides; Theileriasis; Thymidine; Uridine | 1977 |
Thymidylate synthetase and dihydrofolic acid reductase in the stimulated human lymphocyte.
Topics: Cells, Cultured; Deoxyuridine; Floxuridine; Humans; Lectins; Lymphocytes; Methotrexate; Methyltransferases; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidylate Synthase | 1978 |
The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.
Topics: 3-Deazauridine; Animals; Cell Line; DNA, Neoplasm; Floxuridine; Liver Neoplasms, Experimental; Methotrexate; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Uridine | 1978 |
Comparison of thymidine, fluorodeoxyuridine, hydroxyurea, and methotrexate blocking at the G1/S phase transition of the cell cycle, studied by replication patterns.
Topics: Amniotic Fluid; Cell Cycle; Cells, Cultured; Chromosomes, Human; DNA Replication; Floxuridine; History, 16th Century; Humans; Hydroxyurea; Interphase; Methotrexate; Skin; Thymidine | 1978 |
Effect of thymidine on poly(ADP-ribosyl)ation in vivo.
Topics: Cell Nucleus; DNA Replication; DNA, Neoplasm; HeLa Cells; Humans; Hydroxyurea; Kinetics; Methotrexate; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Thymidine | 1979 |
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.
Topics: Animals; Cell Division; Cells, Cultured; Floxuridine; Humans; Hypoxanthines; Leucovorin; Leukemia, Experimental; Methotrexate; Methyltransferases; Mice; Thymidine; Thymidylate Synthase | 1979 |
Enzyme pattern directed chemotherapy. The effects of combinations of methotrexate, 5-fluorodeoxyuridine and thymidine on rat hepatoma cells in vitro.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Depression, Chemical; Floxuridine; Liver Neoplasms; Methotrexate; Rats; Thymidine; Time Factors | 1976 |
Growth rate of cultured Novikoff rat hepatoma cells as a function of the rate of thymidine and hypoxanthine transport.
Topics: Adenosine; Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Dipyridamole; Guanosine; Hypoxanthines; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Rats; Thymidine; Thymine Nucleotides | 1977 |
Thymidine and hypoxanthine requirements for the proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts in the presence of methotrexate.
Topics: Animals; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chickens; Fibroblasts; Hypoxanthines; Methotrexate; Thymidine | 1979 |
Some observations on the reversibility of methotrexate toxicity in normal proliferating tissues.
Topics: Animals; Bone Marrow; Bone Marrow Cells; DNA; Drug Interactions; Drug Therapy, Combination; Hypoxanthines; Intestinal Mucosa; Intestines; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Purines; Pyrimidines; Thymidine | 1977 |
"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.
Topics: Animals; Asparaginase; Breast Neoplasms; Carboxypeptidases; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia; Lung Neoplasms; Lymphoma; Melanoma; Methotrexate; Neoplasms; Osteosarcoma; Tetrahydrofolates; Thymidine | 1977 |
Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines.
Topics: Allopurinol; Animals; Drug Synergism; Female; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Purines; Pyrimidines; Thymidine; Time Factors | 1977 |
Growth requirements of calf lens epithelium in culture.
Topics: Animals; Blood; Cattle; Cell Division; Cell Line; Culture Media; Epithelial Cells; Fibroblasts; Folic Acid; Lens, Crystalline; Leucovorin; Methotrexate; Mice; Mitomycins; Thymidine | 1978 |
Modulation versus rescue of antimetabolite toxicity by salvage metabolites administered by continuous infusion.
Topics: Animals; Drug Therapy, Combination; Duodenal Diseases; Female; Infusions, Parenteral; Inosine; Lethal Dose 50; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1978 |
Cytokinetic comparison of thymidine and leucovorin rescue of marrow in humans after exposure to high-dose methotrexate.
Topics: Bone Marrow; Cell Cycle; DNA, Neoplasm; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine | 1979 |
The biochemistry of the citrovorum factor rescue effect in normal bone marrow cells after high-dose methotrexate.
Topics: Adult; Bone Marrow; Cells, Cultured; Deoxyuridine; Humans; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Osteosarcoma; Thymidine; Thymidine Kinase | 1979 |
Isolation and serial cultivation of rabbit skin epithelial cells.
Topics: Animals; Cell Division; Cells, Cultured; Collagen; Culture Media; Cytological Techniques; Edetic Acid; Egtazic Acid; Epithelial Cells; Epithelium; Female; Male; Methotrexate; Phosphates; Rabbits; Serine; Skin; Thymidine; Trypsin | 1978 |
Cell-cycle dependency of BUdR-induced mutation for six genetic markers in cultured mammalian cells.
Topics: Animals; Asparagine; Bromodeoxyuridine; Cell Cycle; Cytarabine; DNA; Drug Resistance; Genes; L Cells; Methotrexate; Mice; Mutation; Ouabain; Thioguanine; Thymidine | 1979 |
TAM selection of Drosophila somatic cell hybrids.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Cell Line; Drosophila; Drug Resistance; Hybrid Cells; Isocitrate Dehydrogenase; Methotrexate; Mutation; Pentosyltransferases; Phenotype; Thymidine | 1979 |
Thymidine 5'-O-pivaloate. A prodrug derivative of thymidine with potential applications in high-dose methotrexate therapy.
Topics: Animals; DNA; Drug Therapy, Combination; Kinetics; Leukemia L1210; Male; Methotrexate; Mice; Pentanoic Acids; Thymidine | 1979 |
Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine.
Topics: Animals; Cell Division; Cell Line; Cells, Cultured; Deoxyribonucleotides; Dose-Response Relationship, Drug; Humans; Leukemia L1210; Methotrexate; Ribonucleotides; Thymidine | 1979 |
Deoxyuridine metabolism in human megaloblastic marrow cells.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency | 1979 |
Methotrexate di-n-butyl ester effects on thymidine metabolism.
Topics: Animals; Biological Transport; Cells, Cultured; DNA-Directed DNA Polymerase; Kinetics; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymidine Kinase | 1979 |
In vitro sensitivity test of stomach cancer tissues by the use of metal grid method.
Topics: Antineoplastic Agents; Cytarabine; Drug Evaluation, Preclinical; Fluorouracil; Humans; In Vitro Techniques; Methotrexate; Mitomycins; Stomach Neoplasms; Thymidine | 1979 |
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency.
Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1978 |
Thymidine rescue of high-dose methotrexate in humans.
Topics: Adult; Aged; Blood Cells; Bone Marrow; DNA; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine | 1978 |
Biological and biochemical actions of methotrexate in psoriasis.
Topics: Administration, Topical; Animals; Cell Survival; DNA; Dose-Response Relationship, Drug; Humans; Injections, Intradermal; Methotrexate; Mitosis; Psoriasis; Rats; Skin; Thymidine | 1978 |
[Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast (author's transl)].
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Deoxyuridine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Female; Humans; Lymphatic Metastasis; Methotrexate; Thymidine; Uridine | 1978 |
Rate of DNA synthesis as an indication of drug toxicity and as a guide for scheduling cancer therapy.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Lomustine; Methotrexate; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Thymidine | 1978 |
Potentiation of the antitumor activity of methotrexate by concurrent infusion of thymidine.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Thymidine | 1978 |
Rapid separation of low molecular weight solutes from liposomes without dilution.
Topics: Chromatography, Gel; Folic Acid; Inulin; Leucine; Liposomes; Methionine; Methotrexate; Sucrose; Thymidine | 1978 |
In vitro effects of methotrexate, 5-fluorouracil, cyclophosphamide and vincristine sulphate on the metabolism of induced mammary cancers in rats.
Topics: Animals; Cyclophosphamide; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Fluorouracil; In Vitro Techniques; Mammary Neoplasms, Experimental; Methotrexate; Neoplasm Proteins; Rats; Thymidine; Vincristine | 1978 |
Characterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimidine nucleosides.
Topics: Animals; Cell Line; Hypoxanthines; Kinetics; Lymphoma; Methotrexate; Mice; Mutation; Neoplasms, Experimental; Purine Nucleosides; Pyrimidine Nucleosides; Structure-Activity Relationship; Thymidine | 1979 |
Deoxyribonucleic acid chain growth and organization of replicating units in HeLa cells.
Topics: Bromodeoxyuridine; Cycloheximide; DNA Replication; DNA, Neoplasm; Genes; HeLa Cells; Methotrexate; Molecular Weight; Temperature; Thymidine | 1977 |
Relative biochemical aspects of low and high doses of methotrexate in mice.
Topics: Animals; Bone Marrow; Deoxyuridine; DNA; Dose-Response Relationship, Drug; Infusions, Parenteral; Intestine, Small; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Thymidine; Thymidine Monophosphate | 1977 |
The prevention of methotrexate toxicity by thymidine infusions in humans.
Topics: Adult; Aged; Bone Marrow; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Parenteral; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms; Thymidine | 1977 |
Cobalamin dependent methionine synthesis and methyl-folate-trap in human vitamin B12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Folic Acid; Humans; Methotrexate; Methyltransferases; Tetrahydrofolates; Thymidine; Vitamin B 12 Deficiency | 1977 |
Effects of methotrexate on cellular metabolism: some critical elements in the drug-cell interaction.
Topics: Amino Acids; Animals; Biological Transport; Cell Division; Cells; Humans; In Vitro Techniques; Kinetics; Methotrexate; Microtubules; Purines; Pyrimidines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine; Thymidine Monophosphate; Time Factors | 1977 |
[Correlation between the effects of cytostatic agents on leukemia L 1210 in vivo and in the short term test in vitro (author's transl)].
Topics: Animals; Cell Count; Culture Techniques; Deoxyuridine; Doxorubicin; Female; Leucine; Leukemia L1210; Methotrexate; Mice; Thymidine; Time Factors; Uridine; Vinblastine | 1977 |
Factors affecting the growth of Chinese hamster cells in HAT selection media.
Topics: Animals; Cell Line; Culture Media; Drug Resistance; Hypoxanthines; Methotrexate; Mutation; Selection, Genetic; Thymidine | 1976 |
Effect of methotrexate on the cell cycle of L1210 leukemia.
Topics: Animals; Cell Division; DNA, Neoplasm; Leukemia L1210; Methotrexate; Mitotic Index; Thymidine | 1976 |
Inhibition of nucleic acid synthesis by the di-n-butyl ester of methotrexate.
Topics: Cell Line; Deoxyuridine; DNA, Neoplasm; Drug Resistance; Methotrexate; Thymidine; Time Factors | 1976 |
Comparative effects of selected antifolates on transforming human lymphocytes and on established human lymphoblastic cell lines.
Topics: Animals; Cattle; Cell Line; Deoxyuridine; Folic Acid Antagonists; Humans; In Vitro Techniques; Lectins; Liver; Lymphocyte Activation; Methotrexate; Mitosis; Stimulation, Chemical; Thymidine; Time Factors | 1976 |
Inhibition by trimethoprim of some effects of epidermal growth factor on human fibroblasts in tissue culture.
Topics: Cells, Cultured; Epidermal Growth Factor; Fibroblasts; gamma-Aminobutyric Acid; Humans; Methotrexate; Peptides; Thymidine; Trimethoprim | 1976 |
Kinetic aids to proper chemotherapeutic scheduling: labeled nucleoside incorporation studies in vivo.
Topics: Animals; Bone Marrow; Cell Survival; Cyclophosphamide; DNA, Neoplasm; Drug Administration Schedule; Fluorouracil; Granulocytes; Intestinal Mucosa; Kinetics; Lomustine; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Pyrimidine Nucleosides; Thymidine; Uridine | 1976 |
The mechanism of action of methotrexate in cultured L5178Y leukemia cells.
Topics: Animals; Cell Line; Cell Survival; Deoxyuridine; DNA, Neoplasm; Hypoxanthines; Kinetics; Leukemia, Lymphoid; Methotrexate; Mice; Models, Biological; Thymidine; Time Factors | 1975 |
Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells.
Topics: Adenine; Adenosine Triphosphate; Animals; Cell Line; Cytosine Nucleotides; Depression, Chemical; DNA; Guanine; Guanosine Triphosphate; Hypoxanthines; Leucine; Leukemia, Lymphoid; Methotrexate; Mice; Purines; RNA; Thymidine; Time Factors; Uracil Nucleotides; Uridine | 1975 |
Assay of cell-mediated cytotoxicity by tritiated thymidine labeled tumor cells.
Topics: Autoradiography; Cytotoxicity Tests, Immunologic; Fibroblasts; Humans; Immunity, Cellular; Isotope Labeling; Lymphocytes; Methotrexate; Osteosarcoma; Thymidine; Tritium | 1975 |
Nuclear DNA-polymerase estimation in human leukaemic myeloblasts.
Topics: Bone Marrow; Bone Marrow Cells; Cell Nucleus; Cell Transformation, Neoplastic; Cytarabine; DNA Nucleotidyltransferases; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Methotrexate; Neoplasm Proteins; Thymidine; Thymine Nucleotides; Tritium | 1976 |
The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects.
Topics: Allopurinol; Animals; Drug Therapy, Combination; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Thymidine | 1975 |
New approaches to cancer chemotherapy with methotrexate.
Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Purines; Thymidine; Thymine Nucleotides | 1975 |
Effect of cytostatic drugs on nucleic acid synthesis in mouse thymocytes and chick embryo cells.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytarabine; Dactinomycin; Deoxyadenosines; Deoxyuridine; DNA; Fluorouracil; Melphalan; Methotrexate; Mice; Mice, Inbred Strains; Thymidine; Thymus Gland; Triaziquone; Tritium; Uridine; Vinblastine | 1975 |
Methotrexate-thymidine treatment of murine leukemia.
Topics: Allopurinol; Animals; Drug Evaluation, Preclinical; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine | 1975 |
Failure of tritiated thymidine incorporation into DNA to reflect the autoradiographically demonstrable calcium-induced increase in thymic lymphoblast DNA synthesis.
Topics: Animals; Calcium; DNA; Formates; Male; Methotrexate; Rats; T-Lymphocytes; Thymidine; Thymidine Monophosphate; Thymidylate Synthase | 1975 |
Sequential use of methotrexate, folinic acid, and cytosine arabinoside in the treatment of acute leukemia.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Child; Cytarabine; Deoxyuridine; DNA; Drug Administration Schedule; Female; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mitosis; Thymidine; Thymine | 1976 |
The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.
Topics: Adenosine; Animals; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Granulocytes; Guanosine; Hematopoietic Stem Cells; Inosine; Leucovorin; Leukocytes; Male; Methotrexate; Mice; Mice, Inbred C57BL; Ribonucleosides; Thymidine | 1976 |
The stimulation by methotrexate of human chorionic gonadotropin and placental alkaline phosphatase in cultured choriocarcinoma cells.
Topics: Alkaline Phosphatase; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; L-Lactate Dehydrogenase; Leucovorin; Methotrexate; Neoplasm Proteins; Placenta; Pregnancy; RNA, Neoplasm; Thymidine; Uterine Neoplasms | 1976 |
Effects of methotrexate on intraperiplasmic and axenic growth of Bdellovibrio bacteriovorus.
Topics: Bacteria; Cell Division; Culture Media; Cytoplasm; DNA, Bacterial; Drug Antagonism; Escherichia coli; Methotrexate; Microscopy, Phase-Contrast; Mutation; Peptones; Saccharomyces; Tetrahydrofolates; Thymidine; Thymine; Thymine Nucleotides | 1975 |
Mouse myeloma. A model for studies of cell kinetics.
Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Cells; Bone Neoplasms; Cell Division; Cells, Cultured; Cyclophosphamide; Cytarabine; Disease Models, Animal; Kinetics; Melphalan; Methotrexate; Mice; Mice, Inbred BALB C; Myeloma Proteins; Neoplasms, Experimental; Plasmacytoma; Thymidine; Tritium; Vinblastine; Vincristine | 1975 |
Effects of methotrexate esters on normal and psoriatic skin.
Topics: Chemical Phenomena; Chemistry; Chronic Disease; Deoxyuridine; Depression, Chemical; DNA; Humans; Lipids; Methotrexate; Psoriasis; Skin; Solubility; Thymidine | 1975 |
Effects of allopurinol on the therapeutic efficacy of methotrexate.
Topics: Allopurinol; Animals; Chick Embryo; Female; Hypoxanthines; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1975 |
[Effect of methotrexate on the leukemic cell cycle in mouse ascitic leukemia L1210].
Topics: Animals; Ascitic Fluid; Cell Transformation, Neoplastic; Drug Resistance; Drug Synergism; Female; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mitosis; Thymidine; Time Factors; Vinblastine | 1975 |
The effect of cytostatic drugs on the synthesis of DNA in adenocarcinomas of the stomach. An in vitro study.
Topics: Adenocarcinoma; Antineoplastic Agents; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; In Vitro Techniques; Melphalan; Methotrexate; Stomach Neoplasms; Thymidine; Tritium; Uridine; Vinblastine | 1975 |
[Repair replication in synchronous Ehrlich ascites cells after reversal of a methotrexate block (author's transl)].
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Centrifugation, Density Gradient; DNA Repair; DNA Replication; Methotrexate; Mice; Thymidine; Time Factors | 1975 |
Activity of lysosomal enzymes in the various cell cycle phases of synchronized HeLa cells.
Topics: Acetylglucosaminidase; Cathepsins; Cell Division; Colchicine; Deoxyribonucleases; DNA; Galactosidases; Glucuronidase; Glycoside Hydrolases; HeLa Cells; Lysosomes; Methotrexate; Mitosis; Thymidine | 1975 |
Uridine as an inhibitor of thymidine utilization and DNA synthesis in L cells with impeded function of thymidylate synthetase.
Topics: Cell Division; Cytidine; DNA; L Cells; Methotrexate; Protein Biosynthesis; Purine Nucleosides; Pyrimidine Nucleosides; Thymidine; Thymidylate Synthase; Uridine | 1976 |
Ethyl methanesulphonate mutagenesis with L5178Y mouse lymphoma cells: a comparison of ouabain, thioguanine and excess thymidine resistance.
Topics: Animals; Cell Survival; Clone Cells; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Ethyl Methanesulfonate; Genetic Variation; Methotrexate; Mice; Mice, Inbred DBA; Mutation; Ouabain; Thioguanine; Thymidine | 1976 |
Importance of pyrimidine nucleotide salvage pathways for DNA synthesis in skin.
Topics: Animals; Animals, Newborn; Azauridine; Cytidine; DNA; Hydroxyurea; Liver; Methotrexate; Mice; Orotic Acid; Pyrimidine Nucleotides; Rabbits; RNA; Skin; Thymidine; Time Factors; Uridine | 1976 |
Chemosensitivity of head and neck cancer with the rapid thymidine incorporation assay and its clinical application.
Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Child; Cisplatin; Colonic Neoplasms; DNA, Neoplasm; Doxorubicin; Drug Screening Assays, Antitumor; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Mitomycins; Peplomycin; Remission Induction; Stomach Neoplasms; Thymidine; Tritium; Tumor Cells, Cultured | 1992 |
Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines.
Topics: Affinity Labels; Biological Transport, Active; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Leukemia; Methotrexate; Purines; Receptors, Cell Surface; Thymidine; Tumor Cells, Cultured | 1992 |
Nucleoside transport-deficient mutants of PK-15 pig kidney cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Line; Clone Cells; Cytarabine; DNA; Escherichia coli; Flow Cytometry; Floxuridine; Hypoxanthine; Hypoxanthines; Kidney; Kinetics; Membrane Proteins; Methotrexate; Mutation; Nucleoside Transport Proteins; Nucleosides; Plasmids; Recombinant Proteins; Swine; Thymidine; Transfection; Tubercidin; Uridine | 1992 |
Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
Topics: Cell Division; Cell Line; DNA; DNA Damage; DNA, Single-Stranded; Fluorouracil; Formyltetrahydrofolates; Methotrexate; Quinazolines; Rhodamines; Thiophenes; Thymidine; Thymidylate Synthase; Time Factors | 1992 |
Cell kinetics of the rat corneal epithelium.
Topics: Animals; Cornea; Deoxycytidine; DNA; Epithelial Cells; Female; Kinetics; Methotrexate; Mitosis; Mitotic Index; Rats; Rats, Wistar; Thymidine | 1992 |
[High resolution cytogenetic techniques or microcytogenetics].
Topics: Bromodeoxyuridine; Cell Division; Humans; Karyotyping; Methotrexate; Thymidine | 1992 |
Induction of premature centromere division affecting all chromosomes under culture conditions of fragile site expression.
Topics: Cells, Cultured; Centromere; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Humans; Karyotyping; Methotrexate; Reference Values; Thymidine | 1992 |
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replication; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Methotrexate; Pancreatic Neoplasms; Thymidine; Tumor Stem Cell Assay; Zidovudine | 1992 |
Methotrexate induces differentiation of human keratinocytes.
Topics: Cell Differentiation; Cell Division; Cells, Cultured; Humans; In Vitro Techniques; Keratinocytes; Methotrexate; Protein Precursors; Proteins; Thymidine | 1992 |
Modulation of methotrexate cytotoxicity with natural interferon upon human leukemia cell line HL-60.
Topics: Biological Transport; Cell Division; Flow Cytometry; Humans; In Vitro Techniques; Interferon-alpha; Interferon-gamma; Leukemia, Promyelocytic, Acute; Methotrexate; Tetrahydrofolates; Thymidine; Tumor Cells, Cultured | 1991 |
Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytarabine; Drug Synergism; Female; Humans; Leukemia L1210; Leukemia P388; Male; Methotrexate; Mice; Mice, Inbred DBA; Plant Extracts; Tea; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1991 |
Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Methotrexate; Mice; Neoplasms; Tetrahydrofolates; Thymidine | 1991 |
Increasing alkaline DNase activity with substrate specificity for denaturated DNA after high dose methotrexate therapy.
Topics: Bone Marrow; Bone Marrow Cells; Child; Deoxyribonucleases; DNA; DNA Damage; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Isoelectric Focusing; Lymphocytes; Magnesium; Methotrexate; Nucleic Acid Hybridization; Osteosarcoma; Phytohemagglutinins; Substrate Specificity; Thymidine | 1991 |
Isolation and characterization of an L1210 cell line retaining the sodium-dependent carrier cif as its sole nucleoside transport activity.
Topics: 2-Chloroadenosine; Affinity Labels; Animals; Carrier Proteins; Cell Division; Cell Membrane; Cell Survival; Cladribine; Deoxyadenosines; Kinetics; Leukemia L1210; Membrane Transport Proteins; Methotrexate; Mice; Mutation; Nucleosides; Sodium; Thioinosine; Thymidine; Tumor Cells, Cultured | 1990 |
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Topics: Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Methotrexate; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1991 |
Role of hypoxanthine and thymidine in determining methotrexate plus dipyridamole cytotoxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cyclic AMP; Dipyridamole; Drug Synergism; Female; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Ovarian Neoplasms; Thymidine | 1990 |
Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation.
Topics: Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Culture Media; Deoxyuridine; DNA; Female; Folic Acid; Humans; Lectins; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phytohemagglutinins; Thymidine; Tritium | 1990 |
Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Drug Synergism; Humans; Lymphocytes; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thymidine; Tumor Cells, Cultured | 1990 |
Azidothymidine inhibition of thymidine kinase and synergistic cytotoxicity with methotrexate and 5-fluorouracil in rat hepatoma and human colon cancer cells.
Topics: Animals; Cell Line; Cell Survival; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Kinetics; Liver Neoplasms, Experimental; Methotrexate; Rats; Thymidine; Thymidine Kinase; Tumor Cells, Cultured; Zidovudine | 1990 |
Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate.
Topics: Cell Division; Cell Line; Drug Antagonism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Lymphoid Tissue; Methotrexate; Polyglutamic Acid; Tetrahydrofolates; Thymidine; Uridine | 1985 |
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Cells; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Nasopharyngeal Neoplasms; Pentosephosphates; Phosphoribosyl Pyrophosphate; Thymidine | 1987 |
Dipyridamole potentiates the growth-inhibitory action of methotrexate and 5-fluorouracil in human keratinocytes in vitro.
Topics: Cell Division; Dipyridamole; DNA; Drug Synergism; Epidermal Cells; Fluorouracil; Humans; Infant, Newborn; Keratins; Male; Methotrexate; Thymidine | 1989 |
Synergistic effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Aphidicolin; Cell Line; Cytarabine; Diterpenes; DNA Damage; Drug Combinations; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Phosphorylation; Thymidine | 1989 |
Enzyme regulatory site-directed drugs: study of the interactions of 5'-amino-2', 5'-dideoxythymidine (5'-AdThd) and thymidine triphosphate with thymidine kinase and the relationship to the stimulation of thymidine uptake by 5'-AdThd in 647V cells.
Topics: 5'-Nucleotidase; Dideoxynucleosides; Feedback; Humans; Methotrexate; Nucleotidases; Thymidine; Thymidine Kinase; Thymidine Phosphorylase; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.
Topics: Bone Marrow; Bone Marrow Cells; Cell Line; Cell Separation; Cell Survival; Colony-Forming Units Assay; Growth Inhibitors; Hematopoietic Stem Cells; Humans; Inosine; Intracellular Fluid; Leukemia, Myeloid, Acute; Methotrexate; Peptides; Polyglutamic Acid; Thymidine | 1985 |
Agents which decrease intracellular thymidine pools cause an augmentation in human natural killer activity in vitro.
Topics: Dactinomycin; Floxuridine; Glucosamine; Humans; Interferons; Killer Cells, Natural; Methotrexate; Thymidine; Thymidine Monophosphate | 1985 |
Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Arabinofuranosylcytosine Triphosphate; Cycloheximide; Cytarabine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Thymidine; Tumor Cells, Cultured | 1989 |
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Methotrexate; Neoplastic Stem Cells; Quinazolines; Thymidine; Trimetrexate | 1986 |
Prenatal diagnosis of the fragile X using thymidine induction.
Topics: Adult; Amniocentesis; Australia; Chorionic Villi; Female; Floxuridine; Fragile X Syndrome; Humans; Male; Methotrexate; Pregnancy; Prenatal Diagnosis; Sex Chromosome Aberrations; Thymidine | 1987 |
Inhibition of lymphocyte nucleic acid metabolism and antibody production by trimetrexate.
Topics: Antibody Formation; Deoxyuridine; DNA; Humans; Interphase; Lymphocytes; Methotrexate; Nucleic Acids; Quinazolines; Thymidine; Trimetrexate | 1987 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Hypoxanthine:guanine phosphoribosyltransferase activity in primary human osteosarcomas. A rationale for therapy with methotrexate-thymidine rescue?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lung Neoplasms; Male; Methotrexate; Osteosarcoma; Pentosyltransferases; Thymidine | 1987 |
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; Floxuridine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Nucleosides; Quinazolines; Thymidine | 1985 |
Effect of methotrexate on the deoxyuridine suppression test: results with different cell preparations.
Topics: Bone Marrow; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA; Formyltetrahydrofolates; Humans; Methotrexate; Microchemistry; Tetrahydrofolates; Thymidine | 1988 |
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.
Topics: Cell Cycle; Cell Survival; Cycloheximide; DNA; DNA Damage; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Proteins; Quinazolines; Thymidine | 1988 |
Modulation of antifolate cytotoxicity by metabolites from dying cells in a lymphocyte clonal assay.
Topics: Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; Drug Resistance; Humans; Hypoxanthine; Hypoxanthines; Lymphocytes; Methotrexate; Thymidine | 1988 |
In vitro activity of sulfonamides and sulfones against Leishmania major promastigotes.
Topics: Animals; Drug Synergism; Folic Acid Antagonists; Leishmania; Methotrexate; Sulfamoxole; Sulfonamides; Sulfones; Thymidine | 1987 |
Enhancement by hemin of the sensitivity of K562 human leukemic cells to 1-beta-D-arabinofuranosylcytosine.
Topics: Aminolevulinic Acid; Butyrates; Cell Differentiation; Cell Line; Cytarabine; Daunorubicin; Deoxyguanosine; Doxorubicin; Drug Synergism; Erythropoiesis; Heme; Hemin; Humans; Hydroxyurea; Leukemia, Myeloid; Methotrexate; Thymidine; Vincristine | 1986 |
Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine.
Topics: Cell Differentiation; Cells, Cultured; Choriocarcinoma; DNA; DNA Replication; Female; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Methotrexate; Pregnancy; Thymidine; Uterine Neoplasms | 1987 |
High-dose methotrexate therapy with leucovorin rescue: in vitro investigations on human osteosarcoma cell lines.
Topics: Cell Line; Cell Survival; Deoxyuridine; DNA, Neoplasm; Humans; Leucovorin; Methotrexate; Osteosarcoma; Thymidine; Tumor Cells, Cultured | 1987 |
An improved selection procedure for the rescue of hybridomas. A comparative study of methotrexate versus aminopterin.
Topics: Aminopterin; Antibody Formation; Antibody-Producing Cells; Cell Survival; Culture Media; Hybridomas; Methotrexate; Thymidine; Tritium | 1987 |
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Rectal Neoplasms; Thymidine; Thymine Nucleotides | 1987 |
In vitro evaluation of nucleoside transport inhibition in vivo.
Topics: Animals; Biological Transport; Dipyridamole; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Methotrexate; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Nucleosides; Thymidine; Time Factors | 1986 |
Prevention by thymidine against toxicity and glucose uptake inhibition of methotrexate on cultured Ehrlich ascites tumour cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cells, Cultured; Deoxyglucose; Glucose; Methotrexate; Mice; Thymidine | 1986 |
Cell kinetics in selection and stratification of patients for adjuvant therapy of breast carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Carcinoma in Situ; Cell Cycle; DNA, Neoplasm; Epithelium; Evaluation Studies as Topic; Female; Flow Cytometry; Fluorouracil; Humans; Melphalan; Methotrexate; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Thymidine; Tritium | 1986 |
The reversal of effects of methotrexate on toxicity and glucose transport reduction by thymidine in Ehrlich ascites tumor bearing mice.
Topics: Animals; Binding Sites; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Division; Cell Membrane; Cytochalasin B; Deoxy Sugars; Deoxyglucose; Glucose; Methotrexate; Mice; Mice, Inbred ICR; Thymidine | 1986 |
Cell position dependence of labelling thymidine nucleotides using the de novo and salvage pathways in the crypt of small intestine.
Topics: Animals; Deoxyuracil Nucleotides; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mice; Thymidine; Thymidine Kinase; Thymidine Phosphorylase | 1986 |
Perturbation of thymidine kinase regulation: a novel chemotherapeutic approach.
Topics: Cell Division; Cell Survival; Cells, Cultured; Humans; Idoxuridine; Methotrexate; Thymidine; Thymidine Kinase; Thymine Nucleotides; Ureter; Urinary Bladder | 1986 |
Paradoxical effect of BW 301U, a lipophilic antifolate, on methotrexate-inhibitable deoxyuridine incorporation by human hematopoietic cells.
Topics: Antineoplastic Agents; Biological Transport; Bone Marrow; Deoxyuridine; Folic Acid Antagonists; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Methotrexate; Pyrimidines; Thymidine; Tritium | 1985 |
Evidence for the involvement of substrate cycles in the regulation of deoxyribonucleoside triphosphate pools in 3T6 cells.
Topics: Animals; Aphidicolin; Cells, Cultured; Cytidine; Cytidine Diphosphate; Deoxyribonucleotides; Diterpenes; DNA Polymerase II; DNA Replication; Hydroxyurea; Kinetics; Methotrexate; Mice; Radioisotope Dilution Technique; Thymidine; Tritium | 1985 |
S49 mouse lymphoma cells are deficient in hypoxanthine transport.
Topics: Adenine; Animals; Biological Transport; Cell Line; Cricetinae; Cricetulus; Dipyridamole; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lymphoma; Methotrexate; Mice; Permeability; Thymidine; Uridine; Uridine Kinase | 1986 |
An evaluation of high resolution chromosome banding of hematologic cells by methotrexate synchronization and thymidine release.
Topics: Acute Disease; Chromosome Banding; Chronic Disease; Humans; Karyotyping; Leukemia; Metaphase; Methotrexate; Thymidine | 1985 |
Development of methotrexate-resistant human choriocarcinoma cells in culture.
Topics: Biological Transport; Cell Division; Cell Line; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; Culture Media; DNA; Drug Resistance; Female; Humans; Methotrexate; Mutation; Pregnancy; Thymidine | 1985 |
Fidelity of DNA replication in isolated L-cell nuclei.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Cell Nucleus; Centrifugation, Density Gradient; Chemical Precipitation; Cycloheximide; Cytoplasm; Dactinomycin; Deoxyribonucleases; DNA; DNA Replication; Drug Stability; Hot Temperature; Hydroxyapatites; Isotope Labeling; L Cells; Methotrexate; Mice; Nucleic Acid Denaturation; Thymidine; Thymine Nucleotides; Time Factors; Tritium | 1972 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation; Drug Resistance; Fluorouracil; Humans; Methods; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Procarbazine; Radioisotopes; Rats; Scintillation Counting; Thymidine; Triaziquone; Uridine | 1974 |
Incorporation of deoxribonucleic acid by HeLa cells during various phases of the cell cycle.
Topics: Cell Division; Culture Techniques; DNA; HeLa Cells; Methotrexate; Microscopy, Fluorescence; Nucleosides; Pinocytosis; Staining and Labeling; Thymidine | 1965 |
[Experimental investigations on damages of the intestinal mucosa].
Topics: Aminopterin; Animals; Antineoplastic Agents; Autoradiography; DNA; Intestinal Mucosa; Methotrexate; Mice; Rats; Regeneration; Thymidine; Tritium; Ulcer | 1965 |
[Estimation of tumor sensitivity in vitro. I. Comparative studies with the Jensen sarcoma in vivo and in vitro after 1-hour-incubation].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Autoradiography; Cycloparaffins; Dactinomycin; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Methods; Methotrexate; Mustard Compounds; Neoplasm Transplantation; Nucleosides; Rats; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Time Factors; Triaziquone; Tritium; Uridine; Vinblastine | 1969 |
[On the question of preclinical selection of cytostatics in the area of treatment of human tumors].
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Culture Techniques; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; Lung Neoplasms; Methods; Methotrexate; Neoplasms; Neoplasms, Experimental; Radionuclide Imaging; Rats; RNA, Neoplasm; Stimulation, Chemical; Thymidine; Triaziquone; Tritium; Vinblastine; Vincristine | 1969 |
[In vitro measurement of 3H thymidine uptake in Jensen sarcoma under the effect of cytostatics using fluid scintillation spectrometry].
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; In Vitro Techniques; Methotrexate; Radiometry; Rats; Sarcoma, Experimental; Spectrum Analysis; Thymidine; Time Factors; Triaziquone; Tritium; Vincristine | 1970 |
[Serological studies after homologous bone marrow transfusion].
Topics: Adult; Autoradiography; Azathioprine; Blood Group Antigens; Bone Marrow Transplantation; Female; Hemagglutination Tests; Hodgkin Disease; Humans; Methotrexate; Phenotype; Prednisone; Thymidine; Transplantation Immunology; Transplantation, Homologous; Tritium; Vinblastine | 1969 |
Determination of rates of DNA synthesis in cultured mammalian cell populations.
Topics: Animals; Autoradiography; Cell Division; Cell Line; Cells, Cultured; Deoxyuridine; DNA; DNA, Neoplasm; Kinetics; Mast-Cell Sarcoma; Methotrexate; Mice; Mitosis; Neoplasm Transplantation; Thymidine | 1974 |
Factors involved in the synthesis of cyclopropane fatty acids by Streptococcus faecalis.
Topics: Carbon Radioisotopes; Cell Division; Chromatography, Gas; Cyclopropanes; Enterococcus faecalis; Fatty Acids; Folic Acid; Hydrogen-Ion Concentration; Methionine; Methotrexate; Nephelometry and Turbidimetry; Oleic Acids; Temperature; Thymidine; Time Factors | 1974 |
Physiological differences between cyclopropane fatty acid-deficient mutants and the parent strain of Streptococcus faecalis.
Topics: Cell Division; Cell Survival; Chromatography, Thin Layer; Cyclopropanes; Deoxycholic Acid; Drug Resistance, Microbial; Enterococcus faecalis; Fatty Acids; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; Pantothenic Acid; Sodium Chloride; Species Specificity; Temperature; Thymidine; Time Factors; Tyrosine | 1974 |
Studies on thymidine kinase of human liver cells in culture.
Topics: Culture Techniques; Enzyme Repression; Floxuridine; Humans; Liver; Methotrexate; Thymidine; Thymidine Kinase | 1966 |
Inhibition of cell division and cell elongation in higher plants by inhibitors of DNA synthesis.
Topics: Cell Division; DNA; Floxuridine; Gibberellins; In Vitro Techniques; Methotrexate; Mitomycins; Plants, Edible; Thymidine | 1965 |
The effect of treatment with cytotoxic agents on mouse spleen dihydrofolate reductase activity.
Topics: Animals; Cyclophosphamide; Floxuridine; Folic Acid; In Vitro Techniques; Leucovorin; Male; Methotrexate; Mice; Nucleosides; Organ Size; Spleen; Tetrahydrofolate Dehydrogenase; Thymidine | 1967 |
The response in vitro, of continuous cultures of human lymphoblasts (CCRF-CEM cells) to chemotherapeutic agents.
Topics: Animals; Azaserine; Chloramphenicol; Culture Media; Culture Techniques; Cyclophosphamide; Cytarabine; Dactinomycin; Deoxyuridine; Floxuridine; Fluorouracil; Humans; Hydrocortisone; Lymphocytes; Mechlorethamine; Mercaptopurine; Methotrexate; Mitomycins; Puromycin; Thymidine; Triazines; Vincristine | 1967 |
Relations among cell growth, DNA synthesis, and gibberellin action.
Topics: Carbon Isotopes; Chloramphenicol; Dactinomycin; DNA; Ethanol; Floxuridine; Gibberellins; Methotrexate; Mitomycins; Plants, Edible; Puromycin; RNA; Thymidine; Tritium; Uridine | 1967 |
Effect of folinate on thymidine uptake by Pediococcus cerevisiae.
Topics: Aminopterin; Carbon Isotopes; Deoxyuridine; Floxuridine; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Leucovorin; Methotrexate; Pediococcus; Temperature; Thymidine; Thymine; Tritium; Uracil | 1968 |
[Mutation to inhibitor-resistance and backward mutation to inhibitor-sensitivity in cancer cell cultures].
Topics: Animals; Culture Media; Culture Techniques; Floxuridine; Glycine; Hypoxanthines; Mast-Cell Sarcoma; Methotrexate; Mice; Mutation; Neoplasm Transplantation; Thymidine | 1967 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; Follow-Up Studies; Glioma; Humans; Meningioma; Methotrexate; Oligodendroglioma; Radiation-Sensitizing Agents; Thymidine | 1968 |
Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis. I. Variability of S plus G2 periods of first generation cells.
Topics: Benzocycloheptenes; Chromosomes; Culture Media; Culture Techniques; DNA; Floxuridine; Humans; Kinetics; Lectins; Lymphocytes; Methotrexate; Mitosis; Nucleosides; Thymidine; Time Factors; Tritium | 1969 |
[A proof of the entrance of cells into the period of DNA synthesis under the effects of 5-fuoro-2'-desoxyuridine and amethopterin].
Topics: Animals; Autoradiography; Cricetinae; Culture Techniques; Cytosine Nucleotides; DNA; Floxuridine; Methotrexate; Mitosis; Thymidine; Tritium | 1968 |
Distribution of DNA replicator sites in mammalian nuclei after different methods of cell synchronization.
Topics: Animals; Autoradiography; Cell Line; Cell Nucleus; Cricetinae; Culture Techniques; DNA; DNA Replication; Female; Fibroblasts; Floxuridine; Methods; Methotrexate; Microscopy, Electron; Mitosis; Ovary; Thymidine; Tritium | 1970 |
The application of an in vitro technique to the study of epidermal replication and metabolism.
Topics: Culture Techniques; DNA; Folic Acid Antagonists; Growth Inhibitors; Histidine; Humans; Methods; Methotrexate; Nucleosides; Proline; Protein Biosynthesis; Psoriasis; RNA; Skin; Thymidine; Tritium | 1971 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
Distribution of DNA replicator sites in mammalian nuclei. II. Effects of prolonged inhibition of DNA synthesis.
Topics: Adenosine; Animals; Autoradiography; Cell Line; Cell Nucleolus; Cell Nucleus; Cell Survival; Chromatin; Cricetinae; DNA; DNA Replication; Female; Floxuridine; Lung; Methotrexate; Microscopy, Electron; Mitosis; Ovary; Rodentia; Sex Chromatin; Thymidine; Time Factors; Tritium | 1972 |
Mode of action of methotrexate upon insulin-antibody formation in guinea pigs.
Topics: Adenosine; Animals; Antibody Formation; Deoxyadenosines; Depression, Chemical; Drug Antagonism; Floxuridine; Formates; Guanosine; Guinea Pigs; Immunization; Immunosuppressive Agents; Insulin Antibodies; Iodine Isotopes; Leucovorin; Male; Mathematics; Methotrexate; Swine; Tetrahydrofolates; Thymidine; Time Factors | 1972 |
Cellular immune reactions to human leukemia.
Topics: Antigens, Neoplasm; Bone Marrow; Bone Marrow Cells; Cell Membrane; Chromium Isotopes; Cytotoxicity Tests, Immunologic; Humans; Immunity, Cellular; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphocyte Culture Test, Mixed; Mercaptopurine; Methotrexate; Prednisone; Skin Tests; Thymidine; Tritium; Vincristine | 1972 |
Marrow grafts between DL-A-matched canine littermates.
Topics: Animals; Blood Platelets; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Chromosomes; Cobalt Isotopes; Dogs; Graft vs Host Disease; Hematopoietic Stem Cells; Histocompatibility Antigens; Immunosuppression Therapy; Leukocyte Count; Leukocyte Transfusion; Leukocytes; Lymphocyte Culture Test, Mixed; Lymphocytes; Methotrexate; Radiation Effects; Thymidine; Time Factors; Transplantation Immunology; Transplantation, Homologous; Tritium | 1973 |
Initiation and continuation of DNA replication are not associated with the nuclear envelope in mammalian cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Cricetinae; Cytosine Nucleotides; DNA Replication; Female; Floxuridine; Membranes; Methotrexate; Microscopy, Electron; Ovary; Thymidine; Tritium | 1973 |
Isotope-dilution analysis of rate-limiting steps and pools affecting the incorporation of thymidine and deoxycytidine into cultured thymus cells.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Culture Media; Cytidine; Deoxycytidine; Deoxyribonucleosides; Floxuridine; Isotope Labeling; Kinetics; Methotrexate; Rats; Thymidine; Thymidylate Synthase; Thymus Gland; Time Factors; Tritium | 1974 |
The existence of two different metabolic patterns for the synthesis of RNA viruses.
Topics: Adenine; Animals; Antimetabolites; Chick Embryo; Culture Media; Dactinomycin; Enterovirus; Fibroblasts; Formates; Histones; Influenza A virus; Methotrexate; Nucleosides; Orotic Acid; Phenylalanine; Puromycin; Radiation Effects; RNA Viruses; RNA, Viral; Thymidine; Ultraviolet Rays; Uridine | 1966 |
Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine.
Topics: Animals; Antiviral Agents; Avian Leukosis Virus; Cell Division; Chick Embryo; Culture Techniques; DNA, Viral; Fibroblasts; Floxuridine; Methotrexate; RNA, Viral; Thymidine; Tritium; Uridine; Virus Replication | 1967 |
Capillary tube scanning applied to cell growth kinetics.
Topics: Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Biology; Cell Count; Cells; Cells, Cultured; Hypoxanthines; Kinetics; Liver Neoplasms; Lymphoma; Methotrexate; Mice; Mitosis; Neoplasms, Experimental; Photometry; Rats; Thymidine | 1972 |
[Clinical and experimental results of interstitial Curie-therapy combined with radiosensitizing agents in DS carcinoma of the rat and in infiltrating brain neoplasms].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinosarcoma; Cytidine; Ependymoma; Glioblastoma; Humans; Iridium; Methotrexate; Oligodendroglioma; Radiation-Sensitizing Agents; Rats; Thymidine | 1972 |
Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis.
Topics: Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Culture Techniques; Cyclic AMP; Dactinomycin; Deoxyuridine; DNA; Folic Acid; Humans; Lectins; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocyte Activation; Methotrexate; Mitosis; Phosphodiesterase Inhibitors; Puromycin; RNA; Theophylline; Thymidine; Tritium | 1973 |
Letter: On the source of "minor thymine" in DNA from a Novik off rat hepatoma cell line.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chromatography, Paper; Cytosine; Deamination; Deoxycytidine; DNA; Liver; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Rats; Thymidine; Thymine; Tritium | 1973 |
Burkitt's lymphoma: cell kinetics, treatment and immunology.
Topics: Antibodies, Neoplasm; Antibodies, Viral; Burkitt Lymphoma; Culture Techniques; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Herpesvirus 4, Human; Humans; Hypersensitivity, Delayed; Injections, Spinal; Methotrexate; Neoplasm Recurrence, Local; Prognosis; Thymidine; Tritium; Vincristine | 1973 |
The temporal order of replication of some DNA cistrons.
Topics: Animals; Anura; Autoradiography; Bromodeoxyuridine; Cell Division; Cell Line; Cell Nucleus; DNA; DNA Replication; DNA, Viral; Genes; Kidney; Methotrexate; Mice; Operon; Polyomavirus; Ribosomes; Simian virus 40; Thymidine; Time Factors; Tritium | 1974 |
Cell kinetic studies in patients with small cell carcinoma of the lung.
Topics: Autoradiography; Biopsy; Bone Marrow; Carcinoma, Small Cell; Cell Division; Cyclohexanes; Cyclophosphamide; DNA Replication; Humans; Hydroxyurea; Lung Neoplasms; Lymph Nodes; Methotrexate; Nitrosourea Compounds; Remission, Spontaneous; Thymidine; Time Factors; Tritium | 1974 |
Suppression of the avian sarcoma virus genome in hamster-transformed cells made resistant to 8-azaguanine.
Topics: Animals; Antigens, Viral; Avian Sarcoma Viruses; Azaguanine; Carbon Radioisotopes; Cell Division; Cell Fusion; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chickens; Chromosome Mapping; Clone Cells; Cricetinae; Drug Resistance; Genotype; Glycine; Hypoxanthines; Methotrexate; Neoplasms, Experimental; Pentosyltransferases; Phenotype; Polyploidy; Thymidine | 1974 |
Detection of chemical mutagens using a host-mediated assay (L5178Y) mutagenesis system.
Topics: Animals; Biological Assay; Bromodeoxyuridine; Cell Line; Cells, Cultured; Clone Cells; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Leukemia, Lymphoid; Mesylates; Methotrexate; Mice; Mutagens; Mutation; Thymidine | 1974 |
Morphological changes in normal lymphocytes treated with phytohemagglutinin and methotrexate following their interaction with target cells.
Topics: Adsorption; Animals; Antigen-Antibody Reactions; Autoradiography; Cytotoxicity Tests, Immunologic; Fibroblasts; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Thymidine; Time Factors; Transplantation Immunology; Tritium | 1974 |
The effect of heparin on the cytotoxicity and uptake of anti-neoplastic drugs in cultured Burkitt lymphoma cells.
Topics: Burkitt Lymphoma; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Heparin; Humans; Mechlorethamine; Mercaptopurine; Methotrexate; Thymidine; Time Factors; Tritium | 1974 |
The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.
Topics: Animals; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Dose-Response Relationship, Drug; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Thymidine; Time Factors; Tritium; Uridine | 1974 |
Response of a musculo-skeletal tumour to combined radiation therapy. An in vitro/vivo investigation.
Topics: Animals; Cell Line; Glycolysis; Hot Temperature; Lymphatic Metastasis; Methotrexate; Models, Biological; Muscles; Neoplasm Metastasis; Neoplasm Transplantation; Oxygen Consumption; Rabbits; Radiotherapy Dosage; Thymidine; Time Factors; Tritium; Tumor Virus Infections | 1974 |
In vitro estimate of sensitivity of individual human tumors to antitumor agents.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Arsenicals; Benzoates; Breast Neoplasms; Carbon Radioisotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Cattle; Depression, Chemical; DNA, Neoplasm; Female; Fluorouracil; Humans; In Vitro Techniques; Iodoacetates; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Lymphoma, Non-Hodgkin; Mechlorethamine; Methotrexate; Mice; Neoplasms; Phenylalanine; Succinate Dehydrogenase; Thymidine; Tritium | 1974 |
Impaired lymphocyte transformation in leukemic patients after intensive therapy.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cobalt Isotopes; Cytarabine; Female; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Mitogens; Prednisone; Radiation Effects; Remission, Spontaneous; Thymidine; Time Factors; Tritium; Vincristine | 1972 |
Cell kinetics and chemotherapy in acute leukemia.
Topics: Asparaginase; Autoradiography; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Cells, Cultured; Cyclophosphamide; Cytarabine; DNA; Drug Combinations; Exchange Transfusion, Whole Blood; Humans; Hydrocortisone; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Methylprednisolone; Mitosis; Prednisone; Thymidine; Tritium; Vincristine | 1972 |
Selective toxicity of rifamycin derivatives for leukaemic human leucocytes.
Topics: Antibiotics, Antineoplastic; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Differentiation; Cells, Cultured; DNA Nucleotidyltransferases; DNA, Neoplasm; Humans; Hydroxyurea; Kinetics; Leukemia; Leukocytes; Lymphocytes; Mercaptopurine; Methotrexate; Rifampin; RNA, Neoplasm; Thymidine; Tritium; Uridine | 1972 |
Phytohaemagglutinin stimulation of peripheral lymphocytes in children with acute lymphoblastic leukaemia during remission.
Topics: Adolescent; Cell Transformation, Neoplastic; Child; Child, Preschool; Cyclophosphamide; Humans; In Vitro Techniques; Lectins; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Stimulation, Chemical; Thymidine; Time Factors; Tritium; Vincristine | 1972 |
Cell kinetics in human acute lymphoblastic leukemia: computer simulation with discrete modeling techniques.
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Computers; Cytarabine; DNA; Humans; Kinetics; Leukemia, Lymphoid; Methotrexate; Mitosis; Models, Theoretical; Thymidine; Tritium; Vincristine | 1973 |
Effects of chemotherapeutic agents on cell cycle and cellular proliferation: basic and clinical considerations.
Topics: Autoradiography; Bone Marrow Cells; Cell Division; Cyclophosphamide; Cytarabine; DNA; Drug Antagonism; Drug Combinations; Hodgkin Disease; Humans; Hydrocortisone; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Mitosis; Thymidine; Tritium; Vincristine | 1973 |
[Kinetic effect of cytostatic drugs on the generation cycle of human leukaemic blast cells in vivo. A review].
Topics: Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; DNA Nucleotidyltransferases; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Mitosis; Prednisone; Thymidine; Time Factors; Vincristine | 1974 |
Comparison of the effects of methotrexate and pyrimethamine on L5178Y lymphoblasts in cell culture.
Topics: Adenosine; Animals; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Centrifugation; Dose-Response Relationship, Drug; Folic Acid Antagonists; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Mice; Pyrimethamine; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1973 |
Sequestration of PHA-responsive cells (T-lymphocytes) in the bone marrow of leukemic children undergoing long-term immunosuppressive therapy.
Topics: Adolescent; Bone Marrow Cells; Cells, Cultured; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Lectins; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; T-Lymphocytes; Thymidine; Tritium; Vincristine | 1972 |
Absence of the third molar tooth in the mouse: its relevance to human malformation.
Topics: Animals; Anodontia; Deficiency Diseases; DNA; Female; Humans; Injections, Intraperitoneal; Leucovorin; Liver; Methotrexate; Mice; Mice, Inbred CBA; Molar; Thymidine; Tooth Abnormalities; Tritium | 1972 |
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyribonucleotides; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Guanosine; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Phosphates; Thymidine; Tritium | 1973 |
Correlation of cytosine arabinoside-induced increment in growth fraction of leukemic blast cells with clinical response.
Topics: Adult; Aged; Bone Marrow; Bone Marrow Cells; Cell Division; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mitosis; Thymidine; Time Factors; Tritium | 1974 |
Clinical correlates of in vitro effect of methotrexate on acute leukemia blasts.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Cell Biology; Cell Survival; Child; DNA, Neoplasm; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Purines; Remission, Spontaneous; Thymidine; Tritium | 1974 |
Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells.
Topics: Adenosine; Animals; Cell Fusion; Cell Survival; Cells, Cultured; Chromatography, DEAE-Cellulose; Clone Cells; Cricetinae; Crosses, Genetic; Culture Media; DNA; Female; Folic Acid; Glycine; Hybrid Cells; Leucovorin; Methotrexate; Mutation; Ovary; Phenotype; RNA; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1974 |
Factors determining cell sensitivity to methotrexate: studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines.
Topics: Animals; Biological Assay; Cell Count; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxyribonucleotides; Dose-Response Relationship, Drug; Folic Acid; Humans; L Cells; Leukemia L1210; Lymphoma; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Thymidine; Thymidylate Synthase | 1974 |
Proceedings: Cellular kinetics in acute leukemia.
Topics: Acute Disease; Asparaginase; Cell Division; Cell Survival; Cytarabine; DNA; Glucocorticoids; Humans; Leukemia; Methotrexate; Mitosis; Thymidine; Tritium; Vincristine | 1972 |
DNA synthesis in chronic myelogenous leukemia cells: comparison of results in cells containing folate binding factor to replicating cells without binder.
Topics: Anemia, Hypochromic; Binding Sites; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA; DNA Replication; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid; Leukocytes; Lymphoma, Large B-Cell, Diffuse; Methotrexate; RNA; Thymidine; Tritium; Tuberculosis, Lymph Node; Uridine | 1972 |
Comparison of effect of four cytotoxic agents on granulocytic and erythroid repopulating ability of rat bone marrow.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Busulfan; Clone Cells; Cyclophosphamide; Dactinomycin; Erythropoiesis; Female; In Vitro Techniques; Male; Methotrexate; Rats; Spleen; Thymidine; Transplantation, Homologous; Tritium | 1972 |
The proliferative capacity of haemopoietic colony forming units in the rat.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Busulfan; Cell Count; Cell Differentiation; Cell Division; Cell Survival; Chlorambucil; Clone Cells; Female; Femur; Hematopoietic Stem Cells; Injections, Intraperitoneal; Injections, Intravenous; Methotrexate; Rats; Rats, Inbred Strains; Spleen; Thymidine; Time Factors; Tritium | 1973 |
Discontinous antibody secretion during the secondary response to sheep erythrocytes in vitro.
Topics: Adenosine; Animals; Antibody Formation; Antibody-Producing Cells; Antigens; Cells, Cultured; Choline; Erythrocytes; Female; Hemolytic Plaque Technique; Immunologic Memory; Lymphocytes; Methotrexate; Mice; Mice, Inbred BALB C; Spleen; Thymidine; Tritium | 1974 |
Evidence for a temporal incompatibility between DNA replication and division during the cell cycle of Tetrahymena.
Topics: Adenosine; Animals; Autoradiography; Carbon Isotopes; Cell Count; Cell Division; Cell Nucleus; DNA; DNA Replication; Germ-Free Life; Hot Temperature; Leucine; Methotrexate; Micromanipulation; Mitosis; Tetrahymena pyriformis; Thymidine; Time Factors; Tritium; Uridine | 1972 |
Induced elimination of DNA from macronucleus of Tetrahymena pyriformis.
Topics: Animals; Autoradiography; Cell Division; Cell Nucleus; Cytoplasm; DNA; DNA Replication; Isotope Labeling; Methotrexate; Temperature; Tetrahymena pyriformis; Thymidine; Time Factors; Tritium; Uridine | 1972 |
Requirements for DNA replication preceding cell division in Tetrahymena pyriformis.
Topics: Animals; Carbon Isotopes; Cell Division; Centrifugation, Density Gradient; DNA Replication; Hot Temperature; Methotrexate; Tetrahymena pyriformis; Thymidine; Uridine | 1972 |
Interference with nucleoside transport in mouse lymphoma cells proliferating in culture.
Topics: Adenosine; Animals; Ascitic Fluid; Aza Compounds; Biological Transport; Bromodeoxyuridine; Carbon Isotopes; Cell Division; Cell-Free System; Cells, Cultured; Guanosine; Inosine; Lymphoma; Male; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Pyrazoles; Pyrimidinones; Pyrroles; Ribonucleosides; Thymidine; Time Factors; Transplantation, Homologous | 1972 |
Effects of methotrexate on established cell lines of human choriocarcinoma.
Topics: Cell Line; Choriocarcinoma; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Female; Folic Acid Antagonists; Humans; Methotrexate; Neoplasm Proteins; Pregnancy; Thymidine | 1972 |
Determination of therapeutic index of drugs by in vitro sensitivity tests using human host and tumor cell suspensions.
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Humans; In Vitro Techniques; Methotrexate; Neoplasms; Penicillamine; Thymidine; Time Factors; Tritium | 1973 |
Use of plasma-free medium for the in vitro culture of human lymphocytes.
Topics: Adult; Aged; Arsenicals; Cells, Cultured; Culture Media; Female; Humans; Hydrocortisone; Immunity, Cellular; Insulin; Lectins; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Methylcellulose; Neoplasms; Penicillins; Plasma; Streptomycin; Thymidine; Tritium | 1973 |
Threshold methotrexate concentration for in vivo inhibition of DNA synthesis in normal and tumorous target tissues.
Topics: Animals; Ascites; Ascitic Fluid; Bone Marrow; Deoxyuridine; Depression, Chemical; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Duodenum; Intestinal Mucosa; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymine Nucleotides; Tritium | 1973 |
Studies on the mechanism of antifolate induced inhibition on HeLa cell growth.
Topics: Aminopterin; Carbon Isotopes; Folic Acid Antagonists; Glucose; Glutamates; Growth; HeLa Cells; Methotrexate; Pteridines; Tetrahydrofolate Dehydrogenase; Thymidine; Time Factors | 1973 |
Studies on nucleoside deaminase. Increase in activity in HeLa cell cultures caused by cytosine arabinoside.
Topics: Alkaline Phosphatase; Aminohydrolases; Antimetabolites; Carbon Isotopes; Cell Fractionation; Culture Media; Cycloheximide; Cytarabine; Cytidine; Deamination; DNA; DNA Nucleotidyltransferases; Glucosephosphate Dehydrogenase; HeLa Cells; L-Lactate Dehydrogenase; Leucine; Methotrexate; Nucleosides; Protein Biosynthesis; Thymidine; Time Factors; Tritium; Uridine | 1973 |
DNA replication and the nuclear membrane.
Topics: Animals; Autoradiography; Cell Count; Cell Division; Cell Membrane; Cell Nucleus; Cells, Cultured; Cricetinae; DNA; DNA Replication; Female; Fibroblasts; Hydroxyurea; Isotope Labeling; Methotrexate; Microscopy, Electron; Mitosis; Rodentia; Thymidine; Time Factors; Tritium | 1973 |
The role of thymidylate synthetase inhibitors in bromodeoxyuridine-induced neoplasia in Drosophila.
Topics: Animals; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA; Drosophila; Fluorine; Fluorouracil; Idoxuridine; Larva; Methotrexate; Methyltransferases; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Tritium | 1973 |
5-Ethyl-2'-deoxyuridine: evidence for incorporation into DNA and evaluation of biological properties in lymphocyte cultures grown under conditions of amethopterine-imposed thymidine deficiency.
Topics: Autoradiography; Bromodeoxyuridine; Carbon Radioisotopes; Cells, Cultured; Chromosome Aberrations; Culture Media; Deoxyuridine; DNA; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lymphocytes; Methotrexate; Mitosis; Thymidine; Time Factors | 1973 |
An analysis of the relationship of leukemic cell kinetics to chemotherapy.
Topics: Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; DNA; Drug Therapy, Combination; Hematopoietic Stem Cells; Humans; Kinetics; Leukemia; Methotrexate; Mitosis; Prednisone; Thymidine; Tritium; Vincristine | 1973 |
Inhibition of replication and differentiation in malignant mouse neuroblasts.
Topics: Amino Acids; Animals; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Cytarabine; DNA Replication; Methotrexate; Mice; Microscopy, Electron; Neoplasm Proteins; Neoplasms, Experimental; Neuroblastoma; RNA; Thymidine; Tritium; Uridine | 1973 |
The effect of methotrexate on transformation and mitosis of normal human blood lymphocytes in vitro.
Topics: Blood Proteins; Carbon Radioisotopes; Cells, Cultured; Densitometry; DNA; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Mitosis; Phenylalanine; RNA; Thymidine; Time Factors; Tritium; Uridine | 1974 |
Effect of cytostatic drugs on the kinetics of leukemic blast cells in man.
Topics: Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Cell Division; Cytarabine; Daunorubicin; DNA, Neoplasm; Drug Therapy, Combination; Humans; Leukemia; Methotrexate; Mitosis; Prednisone; Spectrophotometry; Thymidine; Time Factors; Vincristine | 1974 |
Synchronization of HeLa cells with 2,3-dihydro-1-H-imidazo(1,2-b)pyrazole.
Topics: Adenosine; Carbon Radioisotopes; Cell Division; Depression, Chemical; DNA; HeLa Cells; Humans; Imidazoles; Leucine; Methotrexate; Mitosis; Protein Biosynthesis; Pyrazoles; RNA; Thymidine; Time Factors; Tritium; Uridine | 1974 |
Changes in the mucosa of the small intestine following methotrexate administration or abdominal x-irradiation.
Topics: Animals; Autoradiography; Cell Movement; Epithelial Cells; Epithelium; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mitosis; Radiation Effects; Rats; RNA; Thymidine | 1974 |
The effect of folate and folate analogs upon dihydrofolate reductase and DNA synthesis in kidneys of normal mice.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Deoxyuridine; DNA; Folic Acid; Folic Acid Antagonists; Isotope Labeling; Kidney; Male; Methotrexate; Mice; Mice, Inbred Strains; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thymidine; Time Factors; Tritium; Ultracentrifugation; Ultrafiltration; Xanthopterin | 1974 |
Cell kinetics and growth of squamous cell carcinomas in man.
Topics: Autoradiography; Biopsy; Carcinoma, Squamous Cell; DNA, Neoplasm; Gingival Neoplasms; Humans; Lip Neoplasms; Methotrexate; Mitosis; Skin Neoplasms; Thymidine; Time Factors; Tritium | 1974 |
The effects of cytostatic drugs on transplanted tumours. An investigation of the correlation between in vivo and in vitro results.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cytarabine; Daunorubicin; Fluorouracil; Melanoma; Methotrexate; Mice; Neoplasm Transplantation; Plasmacytoma; Procarbazine; Rats; Thymidine; Tritium; Uridine | 1974 |
Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Culture Techniques; Deoxyuridine; DNA; Embryo, Mammalian; Escherichia coli; Folic Acid; Histocytochemistry; Kinetics; L Cells; Leucovorin; Methotrexate; Mice; Nucleotides; RNA; Thymidine; Transferases; Tritium | 1969 |
Allogeneic marrow engraftment following whole body irradiation in a patient with leukemia.
Topics: Aspartate Aminotransferases; Autopsy; Bilirubin; Blood Cell Count; Blood Platelets; Bone Marrow; Bone Marrow Examination; Bone Marrow Transplantation; Busulfan; Cobalt Isotopes; Genetics, Medical; Hematocrit; Histocompatibility Testing; Humans; Hydrocortisone; Leukemia, Myeloid; Leukocyte Count; Male; Methotrexate; Middle Aged; Neisseria; Prednisone; Sputum; Thymidine; Transplantation, Homologous; Tritium; Vincristine | 1970 |
Metabolism of leukocytes in a case of acute leukemia.
Topics: Autoradiography; Child; DNA; Female; Folic Acid; Humans; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Methotrexate; Prednisone; Thymidine; Tritium; Uridine; Vincristine; Vitamin B 12 | 1967 |
Studies on the division cycle of mammalian cells. V. Modifications of time parameters by different steady-state culture conditions.
Topics: Animals; Autoradiography; Cell Count; Cell Division; Cell Line; Culture Media; Culture Techniques; Dactinomycin; DNA; Fluorometry; Glucose; Leucine; Mast-Cell Sarcoma; Methods; Methotrexate; Mice; Mitosis; Serum Albumin, Bovine; Thymidine; Time Factors; Tritium | 1971 |
Megaloblastic maturation masked by iron deficiency: a biochemical basis.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Bone Marrow; Culture Techniques; Deferoxamine; Deoxyuridine; DNA; Folic Acid Deficiency; Humans; Iron; Methotrexate; Thymidine; Tritium; Vitamin B 12 Deficiency | 1972 |
Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow.
Topics: Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; DNA; Ethanol; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Pyrimidines; Thymidine; Trimethoprim; Tritium | 1972 |
Purineless death as a link between growth rate and cytotoxicity by methotrexate.
Topics: Animals; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Hypoxanthines; In Vitro Techniques; Leucine; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine; Tritium; Uridine | 1972 |
Effects of nitrogen mustard, methotrexate and hydrocortisone on cell replication in rat ileum and spleen.
Topics: Anemia; Animals; Autoradiography; Blood Cell Count; Body Weight; DNA; DNA Replication; Hydrocortisone; Ileum; Leukopenia; Lymphocytes; Male; Methotrexate; Mitosis; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains; Spleen; Thymidine; Tritium | 1972 |
Activities of immunosuppressive agents in vitro. II. Different timing of azathioprine and methotrexate in inhibition and stimulation of mixed lymphocyte reaction.
Topics: Antigens; Azathioprine; Cell Division; Cytotoxicity Tests, Immunologic; Depression, Chemical; Humans; Immune Adherence Reaction; In Vitro Techniques; Kinetics; Lymphocytes; Methotrexate; Stimulation, Chemical; Thymidine; Tritium; Trypan Blue | 1972 |
Selective action of methotrexate on psoriatic epidermal cells.
Topics: Biopsy; DNA Replication; Humans; Methotrexate; Mitosis; Psoriasis; Skin; Thymidine; Time Factors; Tritium | 1972 |
A mutational assay system using the thymidine kinase locus in mouse lymphoma cells.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Line; Clone Cells; Culture Media; Drug Resistance; Ethylamines; Glycine; Hypoxanthines; Lymphoma; Methane; Methanol; Methotrexate; Mice; Mutation; Neoplasms, Experimental; Phenotype; Radiation Genetics; Sulfonic Acids; Thymidine; Thymidine Kinase; Xanthenes | 1972 |
[Change in lipid antioxidative activity according to cell cycle stages in a HeLa cell culture].
Topics: Antioxidants; Autoradiography; Free Radicals; HeLa Cells; Lipids; Methotrexate; Mitosis; Thymidine; Tritium | 1972 |
The effect of chemotherapeutic agents on the incorporation of DNA precursors by experimental brain tumors.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Bone Marrow; Brain; Brain Neoplasms; Carbon Isotopes; Carmustine; Cyclohexanes; Cytarabine; Deoxyuridine; Disease Models, Animal; DNA, Neoplasm; Dose-Response Relationship, Drug; Ependymoma; Glioma; Lymph Nodes; Male; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Thymidine; Tritium | 1972 |
Inhibition of cell dcivision and denervation hypersensitivity in skeletal muscle.
Topics: Acetylcholine; Animals; Fluorouracil; Hindlimb; Methotrexate; Mitosis; Muscle Contraction; Muscle Denervation; Muscles; Rats; Receptors, Drug; Thymidine; Tritium; Vincristine | 1972 |
Reversal of resistance to methotrexate in L1210 murine leukemia by uracil.
Topics: Animals; DNA; Drug Resistance; Leukemia L1210; Mercaptopurine; Methotrexate; Nucleic Acids; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium; Uracil | 1971 |
The effect of methotrexate on newborn rat skin.
Topics: Animals; Cells; DNA; Folic Acid Antagonists; Methotrexate; Rats; Skin; Thymidine; Tritium | 1971 |
The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.
Topics: Animals; Body Weight; Depression, Chemical; DNA; Epithelial Cells; Folic Acid Antagonists; Intestinal Mucosa; Intestine, Small; Lethal Dose 50; Liver; Male; Methotrexate; Mice; Mitosis; Organ Size; Phosphates; Phosphorus Isotopes; Thymidine; Tritium; Uridine | 1971 |
A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bone Marrow; Carrageenan; Edema; Indomethacin; Leukocytes; Macrophages; Male; Mefenamic Acid; Methotrexate; Phagocytosis; Phenylbutazone; Pleurisy; Radiation Effects; Rats; Thymidine; Tritium; Turpentine | 1971 |
Spontaneous and x-ray-induced genotypic and phenotypic resistance to 5-iodo-2'-deoxyuridine in lymphoma cells in vitro.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Drug Resistance; Genotype; Hypoxanthines; Idoxuridine; Lymphoma; Methotrexate; Mice; Mutation; Phenotype; Radiation Dosage; Radiation Genetics; Thymidine; Time Factors | 1971 |
Syndrome of unilateral ectromelia, psoriasis and central nervous system anomalies.
Topics: Abnormalities, Multiple; Autoradiography; Birth Weight; Cell Division; Central Nervous System; DNA; Ectromelia; Female; Functional Laterality; Genes, Dominant; Humans; Infant; Male; Methotrexate; Musculoskeletal Abnormalities; Pedigree; Psoriasis; Skin; Syndrome; Thymidine; Tritium | 1971 |
Dihydrofolate reductase activity and deoxynucleoside incorporation into DNA of human leukocytes. Relation to methotrexate administration.
Topics: Adolescent; Adult; Child; Child, Preschool; Deoxyuridine; DNA; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Methotrexate; Middle Aged; Nucleosides; Tetrahydrofolate Dehydrogenase; Thymidine | 1967 |
The metabolism of basic proteins in HeLa cell nuclei.
Topics: Carbon Isotopes; Cell Nucleus; Culture Techniques; DNA; Electrophoresis; HeLa Cells; Histones; Methotrexate; Nucleoproteins; Thymidine | 1966 |
Coordinated changes in biochemical patterns: the effect of cytosine arabinoside and methotrexate on leukocytes from patients with acute granulocytic leukemia.
Topics: Acute Disease; Cytarabine; Deoxyuridine; DNA; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Ligases; Methotrexate; Phosphotransferases; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidine Kinase | 1969 |
Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1969 |
Proliferative potential of out-of-cycle leukaemic cells.
Topics: Bone Marrow; Bone Marrow Cells; Cell Division; Humans; Leukemia, Lymphoid; Methotrexate; Thymidine; Tritium | 1969 |
Perturbation of generation cycle of human leukemic blast cells by cytostatic therapy in vivo: effect of corticosteroids.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antineoplastic Agents; Autoradiography; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; DNA; Female; Humans; Leukemia, Lymphoid; Lymphocytes; Male; Methotrexate; Methylprednisolone; Microscopy, Electron; Middle Aged; Mitosis; Prednisone; Spectrophotometry; Thymidine; Tritium; Vincristine | 1970 |
The potentiality of out-of-cycle acute leukemic cells to synthesize DNA.
Topics: Adult; Aged; Autoradiography; Child; Cyclophosphamide; Daunorubicin; DNA Replication; Female; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Methotrexate; Middle Aged; Prednisone; Radiation Effects; Thymidine; Tritium; Ultraviolet Rays; Vincristine | 1970 |
Methotrexate inhibition of deoxyuridine incorporation in the skin of three day old rats.
Topics: Animals; Deoxyuridine; Depression, Chemical; DNA; Folic Acid Antagonists; Methotrexate; Rats; Skin; Thymidine; Tritium | 1971 |
[Autoradiographic and enzyme-chemical studies of the DNA synthesis in leukemia cells. II. Thymidine-kinase and 3H-thymidine labelling index under cytostatic therapy].
Topics: Adolescent; Adult; Autoradiography; Cell Differentiation; Cytarabine; DNA, Neoplasm; Female; Histocytochemistry; Humans; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone; Thymidine; Thymidine Kinase; Tritium | 1970 |
Synchronization and recruitment in acute leukemia.
Topics: Adult; Antineoplastic Agents; Asparaginase; Bone Marrow; Bone Marrow Cells; Child; Culture Techniques; Cyclophosphamide; Cytarabine; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Exchange Transfusion, Whole Blood; Humans; Hydrocortisone; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Methotrexate; Mitosis; Thymidine; Tritium; Vincristine | 1971 |
Perturbation of generation cycle of human leukemic myeloblasts in vivo by methotrexate.
Topics: Aged; Autoradiography; Bone Marrow Examination; Deoxyuridine; DNA; Erythrocytes; Female; Hematopoietic Stem Cells; Humans; Kinetics; Leukemia, Myeloid, Acute; Leukocytes; Male; Methotrexate; Middle Aged; Mitosis; Spectrophotometry; Thymidine; Tritium; Vincristine | 1971 |
Growth rate and cell kill.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Humans; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Biochemical and pathophysiological rationale for amethopterin in psoriasis.
Topics: Administration, Oral; Autoradiography; Deoxyuridine; Epithelium; Germ Cells; Humans; Injections, Intramuscular; Methotrexate; Mitosis; Psoriasis; Skin; Thymidine; Time Factors; Tritium | 1971 |
Prediction of methotrexate responsiveness of tumors in man.
Topics: Deoxyuridine; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Prognosis; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1971 |
[The effect of the folic acid antagonists (Methotrexate) on regeneration of the intestinal mucosa].
Topics: Animals; Autoradiography; DNA; Female; Intestinal Mucosa; Intestines; Methotrexate; Mice; Regeneration; Thymidine; Tritium | 1966 |
Studies relating to the mode of action of methotrexate. II. Studies on sites of action in L-cells in vitro.
Topics: Animals; Cattle; Culture Media; Culture Techniques; L Cells; Leucovorin; Methotrexate; Nucleosides; Nucleotides; Purines; Tetrahydrofolate Dehydrogenase; Thymidine | 1969 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine | 1971 |
Homofolate and tetrahydrohomofolate, inhibitors of purine synthesis.
Topics: Animals; Culture Media; Culture Techniques; Folic Acid; Glycine; Leucovorin; Methotrexate; Neoplasms, Experimental; Purines; Sarcoma, Experimental; Thymidine | 1971 |
Elevation of thymidylate synthetase activity in CCRF-CEM cells.
Topics: Cell Line; Cells, Cultured; Child; Deoxyuridine; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Methotrexate; Methyltransferases; Thymidine; Uracil Nucleotides | 1971 |
Cell proliferation kinetics in benign and malignant skin diseases in humans.
Topics: Autoradiography; Carcinoma, Basal Cell; Cell Division; DNA; DNA, Neoplasm; Humans; Ichthyosis; Injections, Intramuscular; Kinetics; Methotrexate; Mitosis; Psoriasis; Skin; Skin Diseases; Skin Neoplasms; Thymidine; Tritium | 1969 |
Effect of anti-leukemic drugs on cell cycle of human leukemic blast cells in vivo.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Cell Transformation, Neoplastic; DNA, Neoplasm; Humans; Leukemia; Male; Methotrexate; Prednisone; Thymidine; Tritium | 1969 |
[A new method for the determination of the rate of DNA-synthesis in bone marrow cells in vitro].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Culture Media; Culture Techniques; DNA; Methotrexate; Models, Biological; Nucleosides; Rats; Thymidine; Tritium; Uridine | 1969 |
[Determination of DNA synthesis time of bone marrow cells in vitro using quantitative autoradiography].
Topics: Animals; Autoradiography; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; DNA; In Vitro Techniques; Methotrexate; Rats; Thymidine; Time Factors | 1969 |
S-phase cells of rapidly growing and resting populations. Differences in response to methotrexate.
Topics: Animals; Cell Line; Clone Cells; Culture Techniques; Deoxyuridine; DNA; Folic Acid Antagonists; Kinetics; Leukemia, Experimental; Methotrexate; Mice; Thymidine; Time Factors; Tritium | 1969 |
DNA polymerase from HeLa cell nuclei: levels of activity during a synchronized cell cycle.
Topics: Cell Nucleus; Chemical Precipitation; Culture Techniques; Cytoplasm; DNA; DNA Nucleotidyltransferases; HeLa Cells; Methotrexate; Mitosis; Quaternary Ammonium Compounds; Solubility; Stimulation, Chemical; Sulfates; Thymidine; Tritium; Vibration | 1970 |
Congenital bullous ichthyosiform erythroderma. Epidermolytic hyperkeratosis--treatment with methotrexate.
Topics: Administration, Oral; Adolescent; Autoradiography; Epidermolysis Bullosa; Female; Humans; Ichthyosis; Imidazoles; Infant, Newborn; Male; Methotrexate; Purines; Thymidine; Tritium | 1970 |
Synchronization of DNA synthesis in Tetrahymena populations by temporary limitation of access to thymine compounds.
Topics: Animals; Cell Division; Culture Techniques; DNA; DNA Replication; Methotrexate; Protein Biosynthesis; RNA; Tetrahymena; Thymidine; Uridine | 1970 |
Independent synchronization of DNA synthesis and of cell division in same culture of Tetrahymena cells. Demonstration that heat-shock induced division-synchrony is by differential extension of the G2 phase.
Topics: Animals; Cell Division; Culture Techniques; DNA; DNA Replication; Hot Temperature; Methotrexate; Protein Biosynthesis; RNA; Tetrahymena; Thymidine; Time Factors; Tritium | 1970 |
Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis. II. Kinetics of the initiation of the proliferative response.
Topics: Culture Techniques; DNA; DNA Replication; Humans; Lectins; Lymphocytes; Methotrexate; Mitosis; Thymidine; Time Factors; Tritium | 1970 |
H-1 virus growth in synchronized rat embryo cells.
Topics: Animals; Autoradiography; Carbon Isotopes; Culture Techniques; DNA; DNA Viruses; Embryo, Mammalian; Methotrexate; Mitosis; Nucleosides; Rats; Thymidine; Virus Replication | 1970 |
Transport of folinate and related compounds in Pediococcus cerevisiae.
Topics: Aminopterin; Biological Transport; Folic Acid; Glucose; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Pediococcus; Temperature; Thymidine; Tritium | 1970 |
[Synchronization of the processes in the cell cycle].
Topics: Animals; Carcinoma, Ehrlich Tumor; Chickens; Cold Temperature; Cricetinae; Culture Techniques; DNA; Erythrocytes; HeLa Cells; Hot Temperature; Humans; Mathematics; Methods; Methotrexate; Mice; Mitosis; Models, Biological; Plants; Temperature; Thymidine | 1970 |
[Effect of methotrexate on DNA synthesis in human lymphocytes stimulated with phytohemagglutinin].
Topics: DNA; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Phosphorus Isotopes; RNA; Thymidine | 1970 |
[Indication for antineoplastic agents (using 3H-thymidine)].
Topics: Antineoplastic Agents; Culture Techniques; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; Methotrexate; Mitomycins; Stomach Neoplasms; Thymidine; Tritium; Vinblastine | 1971 |
Effect of methotrexate on pyrimidine metabolism in regenerating rat liver.
Topics: Animals; Carbon Isotopes; DNA; Hepatectomy; Liver; Liver Regeneration; Male; Methotrexate; Nucleosides; Orotic Acid; Pyrimidines; Rats; Thymidine; Thymine | 1968 |
Studies on thymidine kinase, thymidylate kinase, and deoxycytidylate deaminase of Chang liver cells.
Topics: Aminohydrolases; Carbon Isotopes; Culture Techniques; Cytosine Nucleotides; Dactinomycin; DNA; Feedback; Growth; Humans; Hydroxyurea; Liver; Methotrexate; Mitomycins; Nucleosides; Nucleotides; Phosphotransferases; Puromycin; Thymidine; Thymidine Kinase; Time Factors | 1968 |
Initiation of deoxyribonucleic acid replication at the nuclear membrane in human cells.
Topics: Autoradiography; Cell Division; Cell Nucleolus; Cell Nucleus; Culture Techniques; DNA; DNA Replication; Humans; Membranes; Methotrexate; Microscopy, Electron; Thymidine; Tritium | 1968 |
Effects of cytosine arabinoside on the cell viability and uptake of deoxypyrimidine nucleosides in L5178Y cells.
Topics: Animals; Culture Techniques; Cytarabine; Depression, Chemical; DNA, Neoplasm; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Nucleosides; Phosphates; RNA, Neoplasm; Thymidine; Tritium | 1968 |
Thymine starvation by inhibition of uptake and synthesis of thymine-compounds in Tetrahymena.
Topics: Cell Division; DNA; Hot Temperature; Methotrexate; Nucleosides; Tetrahymena; Thymidine; Thymine; Tritium; Uracil; Uracil Nucleotides; Uridine | 1968 |
Studies on the division cycle of mammalian cells. II. Causal relationship between completion of DNA synthesis and onset of the G2 period.
Topics: Animals; Autoradiography; Cell Division; Culture Techniques; DNA; Methotrexate; Thymidine; Tritium | 1968 |
Production of highly labeled adenoviruses.
Topics: Adenoviridae; Centrifugation, Density Gradient; Culture Techniques; DNA, Viral; Hydrolases; Methotrexate; Microscopy, Electron; Thymidine; Tritium; Virus Cultivation | 1968 |
Investigation of bone-marrow stem cell proliferation in normal, anemic, and irradiated rats, using methotrexate and tritiated thymidine.
Topics: Anemia; Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Injections, Intravenous; Methotrexate; Phenylhydrazines; Radiation Effects; Rats; Thymidine; Tritium | 1968 |
On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA.
Topics: Animals; Deoxyuridine; DNA, Neoplasm; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Transplantation; Nucleosides; Nucleotides; Thymidine | 1968 |
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Homocysteine; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymidine; Transferases; Tritium; Vitamin B 12 Deficiency | 1969 |
The effect of methotrexate on enzymes induced following partial hepatectomy.
Topics: Aminohydrolases; Animals; Carbon Isotopes; Cycloheximide; Dactinomycin; DNA Nucleotidyltransferases; Enzyme Induction; Hepatectomy; Ligases; Liver; Methotrexate; Phosphotransferases; Puromycin; Rats; RNA, Messenger; Stimulation, Chemical; Thymidine; Thymidine Kinase; Time Factors | 1969 |
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Diseases; Chorioretinitis; Culture Techniques; Deoxyuridine; DNA; Erythrocytes; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nucleotides; Oxidation-Reduction; Pyrimethamine; Thymidine; Tritium | 1969 |
Cell killing studies on the mode of action of methotrexate on L-cells in vitro.
Topics: Amino Acids; Cell Division; Culture Media; Culture Techniques; Folic Acid; Humans; L Cells; Methotrexate; Nucleotides; Thymidine; Time Factors | 1969 |
Further studies on biological properties of mammalian cell lines resistant to 5-bromodeoxyuridine.
Topics: Animals; Bromodeoxyuridine; Chromosomes; Cricetinae; DNA; Fibroblasts; Idoxuridine; Methotrexate; Mice; Thymidine; Thymidine Kinase; Tritium | 1965 |
3',5'-ditritiomethotrexate as a granulocyte label.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Chromatography; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Leukocytes; Methotrexate; Radiometry; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1965 |
Variations in the nucleoside triphosphate content and oxygen uptake of synchronized HeLa S3 cultures.
Topics: Adenosine Triphosphate; Cell Division; Culture Techniques; Firefly Luciferin; Glycerophosphates; HeLa Cells; Luciferases; Methotrexate; Nucleotides; Oxygen Consumption; Thymidine | 1965 |
Control of self-irradiation decomposition of tritium-labelled compounds at high specific activity.
Topics: Alcohols; Drug Stability; Ethanol; Folic Acid; Formates; Histidine; Leucine; Methotrexate; Nucleosides; Penicillin G; Radiation-Protective Agents; Thymidine; Tritium; Tyrosine; Uridine | 1966 |
Histological and biochemical considerations in the treatment of oral cancer with preoperative methotrexate infusion.
Topics: DNA, Neoplasm; Humans; Infusions, Parenteral; Methotrexate; Mouth Neoplasms; Preoperative Care; Thymidine; Tritium | 1966 |
Purine pyrophosphorylase as a selective genetic marker in a mouse lymphoma, P388, in cell culture.
Topics: Animals; Azaguanine; Clone Cells; Culture Media; Culture Techniques; DNA, Neoplasm; Glycine; Hypoxanthines; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Purines; Thymidine | 1966 |
Elevation of deoxyribonuclease activities in HeLa cells treated with selective inhibitors of DNA synthesis.
Topics: Antimetabolites; Cell Division; Culture Techniques; Deoxyribonucleases; DNA; HeLa Cells; Humans; Mechlorethamine; Methotrexate; Mitomycins; Thymidine; Urea | 1966 |
A model system for examining the action of anti-cancer agents at the cellular level in vivo.
Topics: Animals; Antineoplastic Agents; Azaserine; Cyclophosphamide; Dactinomycin; Fluorouracil; Hematopoiesis; Lymphoma; Mechlorethamine; Methotrexate; Mice; Models, Theoretical; Neoplasm Transplantation; Neoplasms, Experimental; Spleen; Thymidine; Tritium; Vinblastine | 1967 |
Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.
Topics: Animals; Cells, Cultured; Liver Neoplasms, Experimental; Methotrexate; Peptides; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Thymidine | 1980 |
Methotrexate cytotoxicity in cultured human leukemic cells studied by flow cytometry.
Topics: Acridine Orange; Cells, Cultured; Cytological Techniques; DNA; Dose-Response Relationship, Drug; Fluorescence; Humans; Hypoxanthines; Interphase; Leukemia; Methotrexate; RNA; Thymidine | 1981 |
Methotrexate cytotoxicity: studies on its reversal by folates and nucleosides.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Head and Neck Neoplasms; Humans; Hypoxanthines; Inosine; Leukemia L1210; Methotrexate; Mice; Nucleosides; Phosphoribosyl Pyrophosphate; Thymidine | 1981 |
Differential effects of folinic acid and glycine, adenosine, and thymidine as rescue agents in methotrexate-treated human cells in relation to the accumulation of methotrexate polyglutamates.
Topics: Adenosine; Deoxyuridine; DNA; Fibroblasts; Glycine; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Thymidine; Time Factors | 1982 |
Methotrexate polyglutamates in cultured human cells.
Topics: Adenosine; Cells, Cultured; Deoxyuridine; DNA Replication; Fibroblasts; Glycine; Humans; Methotrexate; Peptides; Polyglutamic Acid; Protein Binding; Tetrahydrofolate Dehydrogenase; Thymidine | 1983 |
Thymidine enhancement of methotrexate and 5-fluorouracil toxicity in cultured human colon carcinoma.
Topics: Cells, Cultured; Colonic Neoplasms; Drug Interactions; Flow Cytometry; Fluorouracil; Humans; Kinetics; Methotrexate; RNA; Thymidine | 1984 |
Effect of methotrexate on cells in a keratinized epithelium with an active thymidine salvage pathway assessed by autoradiography.
Topics: Animals; Autoradiography; Cell Cycle; Cheek; Cricetinae; DNA Replication; Epithelial Cells; Epithelium; Flow Cytometry; Keratins; Kinetics; Male; Mesocricetus; Methotrexate; Mouth Mucosa; Thymidine; Tritium; Uridine | 1984 |
Antimitotic drugs that enhance neuronal survival in olfactory bulb cell cultures.
Topics: Animals; Bromodeoxyuridine; Cells, Cultured; Cytarabine; Depression, Chemical; Floxuridine; Hydroxyurea; Methotrexate; Mitosis; Olfactory Bulb; Potassium; Rats; Rats, Inbred Strains; Thymidine | 1983 |
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Thymidine; Tritium | 1983 |
Rate of DNA synthesis in exponentially growing cell lines in the presence and absence of antimetabolites.
Topics: Antimetabolites; Cell Line; DNA; Floxuridine; Methotrexate; Thymidine; Thymidylate Synthase | 1983 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate | 1984 |
Thymidine and hypoxanthine requirements of normal and malignant human cells for protection against methotrexate cytotoxicity.
Topics: Bone Marrow Cells; Cell Division; Cell Line; Cell Survival; Cell Transformation, Viral; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Herpesvirus 4, Human; Humans; Hypoxanthines; Lymphocytes; Methotrexate; Thymidine | 1981 |
Biochemical mechanisms in the Killmann experiment: critique of the deoxyuridine suppression test.
Topics: Deoxyribonucleosides; Deoxyuridine; DNA; Floxuridine; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Methotrexate; Phytohemagglutinins; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1980 |
Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.
Topics: Animals; Cell Line; Drug Resistance; Floxuridine; Mammary Neoplasms, Experimental; Methotrexate; Methyltransferases; Mice; Mutation; Tetrahydrofolates; Thymidine; Thymidine Kinase; Thymidylate Synthase | 1981 |
Comparison of cytostatic sensitivities of L 1210 cells and human stimulated lymphocytes in three cell proliferation assays.
Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cell Division; Cells, Cultured; Cytarabine; Dose-Response Relationship, Drug; Growth Inhibitors; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Thymidine | 1980 |
Influence of concomitant infusion of thymidine and inosine on methotrexate activity in normal and P388-bearing mice.
Topics: Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1984 |
Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells.
Topics: Animals; Biological Transport; Deoxycytidine; Deoxyuridine; Dipyridamole; DNA Replication; Drug Antagonism; Kinetics; Methotrexate; Mice; Sarcoma 180; Thymidine; Thymine Nucleotides | 1984 |
A mechanism for the stimulation by inorganic mercury of [3H] thymidine incorporation into DNA in cultured Molt-4F cells.
Topics: Cell Line; DNA, Neoplasm; Humans; Leucine; Leukemia; Mercury; Methotrexate; T-Lymphocytes; Thymidine; Thymidine Kinase; Tritium | 1983 |
Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine.
Topics: Adolescent; Adult; Child; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Inulin; Kidney Diseases; Kinetics; Leucovorin; Methotrexate; Neoplasms; Thymidine | 1983 |
Improved therapeutic index with high-dose methotrexate: comparison of thymidine-purine rescue with citrovorum factor rescue in mice.
Topics: Animals; Brain Neoplasms; Deoxycytidine; DNA Replication; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymine | 1984 |
In vivo effects of cytosine arabinoside on deoxyribonucleic acid replication in Chinese hamster ovary cells. 2. Cytosine arabinoside affects the rate of synthesis but not the pattern of labeling of an amplified chromosomal sequence at the onset of the S p
Topics: Animals; Carbon Radioisotopes; Cell Line; Chromosomes; Cricetinae; Cricetulus; Cytarabine; DNA Replication; Drug Resistance; Female; Gene Amplification; Interphase; Kinetics; Methotrexate; Ovary; Thymidine; Tritium | 1983 |
Critical modulation by thymidine and hypoxanthine of sequential methotrexate-5-fluorouracil synergism in murine L1210 cells.
Topics: Animals; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Methotrexate; Mice; Thymidine | 1983 |
The influence of methotrexate and thymidine on the human natural killer cell function in vitro.
Topics: Adult; Antimetabolites, Antineoplastic; Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Folic Acid Antagonists; Humans; Killer Cells, Natural; Methotrexate; Thymidine; Thymidine Monophosphate | 1983 |
[Cell cycles of cancer cells and chemotherapy--flow cytometric observation of the effects of chemotherapeutic agents on cell kinetics of cultured human lung cancer cells].
Topics: Adenoma; Carcinoma; Cells, Cultured; DNA, Neoplasm; Doxorubicin; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Kinetics; Lung Neoplasms; Methotrexate; Thymidine | 1983 |
Methotrexate with thymidine protection or rescue in advanced head and neck cancer: a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Digestive System; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Thymidine | 1984 |
Synergism between purines and thymidine (TDR) in reversal of methotrexate (MTX) toxicity in mice using continuous infusions.
Topics: Adenine; Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Kinetics; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1984 |
Comparative analysis of high-resolution chromosome techniques for leukemic bone marrows.
Topics: Bone Marrow; Chromosome Banding; Chromosomes, Human; Cytological Techniques; DNA; Humans; Leukemia; Methotrexate; Thymidine; Tritium | 1982 |
Derangement of DNA synthesis in erythroleukaemia. Normal deoxyuridine suppression and impaired thymidine incorporation in bone marrow culture.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; DNA; Female; Folic Acid Deficiency; Humans; Leukemia, Erythroblastic, Acute; Male; Methotrexate; Middle Aged; Thymidine; Vitamin B 12 Deficiency | 1980 |
[Effect of a new synthetic C-nucleoside on the growth of Ehrlich ascites tumor cells. (author's transl)].
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Indolequinones; Methotrexate; Mice; Mitomycin; Mitomycins; Mitosis; Nucleosides; Thymidine; Time Factors | 1980 |
Effects of methotrexate in vitro on epidermal cell proliferation.
Topics: Animals; Cell Division; Cell Movement; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Fetal Blood; Hot Temperature; Hydroxyurea; Methotrexate; Mitotic Index; Skin; Swine; Thymidine; Time Factors | 1983 |
Isolation of tumor cells from patients with osteosarcoma and analysis of their sensitivity to methotrexate.
Topics: Cell Separation; Cells, Cultured; Deoxyuridine; DNA; Drug Resistance; Humans; Hypoxanthines; Lung Neoplasms; Methotrexate; Osteosarcoma; Stimulation, Chemical; Thymidine | 1981 |
Biochemical control of high-dose methotrexate/Leucovorin rescue therapy.
Topics: Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine; Thymidine Kinase | 1980 |
Reversal of methotrexate inhibition of colony growth of L1210 leukemia cells in semisolid medium.
Topics: Animals; Bone Marrow; Cell Division; Clone Cells; Culture Media; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Thymidine | 1981 |
Reversal of the in vitro methotrexate suppression of cell-mediated immune response by folinic acid and thymidine plus hypoxanthine.
Topics: Animals; Cells, Cultured; Drug Interactions; Hypoxanthines; Immune Tolerance; Immunity, Cellular; Leucovorin; Methotrexate; Mice; Thymidine; Time Factors | 1980 |
The intracellular mechanism of action of metoprine (DDMP).
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimethamine; Pyrimidines; Thymidine | 1980 |
Physiological and enzymatic properties of a thymidine-requiring Pediococcus cerevisiae mutant.
Topics: Aminopterin; Folic Acid; Leucovorin; Methotrexate; Methyltransferases; Mutation; Pediococcus; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidylate Synthase | 1982 |
Phase I study of high-dose methotrexate with thymidine and low-dose leucovorin.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine | 1982 |
Comparison of thymidine and folinic acid protection from methotrexate toxicity in human lymphoid cell lines.
Topics: B-Lymphocytes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Lymphocytes; Methotrexate; T-Lymphocytes; Thymidine | 1982 |
[Radiational basis and practice of the citrovorum factor (Leucovorin) protection after high-dose methotrexate therapy. High-dose methotrexate/leucovorin].
Topics: Bone Marrow; Deoxyuridine; DNA; Dose-Response Relationship, Drug; Humans; Leucovorin; Lymphocytes; Methotrexate; Thymidine | 1980 |
The effects of methylated thymidines upon cultures of V79 cells and the mechanism of incorporation of O4-methylthymidine into their DNA.
Topics: Animals; Cell Count; Cell Line; Cell Survival; Cricetinae; Cricetulus; Deoxycytidine; DNA; Drug Interactions; Methotrexate; Mutation; Thymidine; Time Factors | 1982 |
Characteristic abnormality of deoxyribonucleoside triphosphate metabolism in megaloblastic anemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyribonucleosides; Deoxyuridine; Humans; Methotrexate; Thymidine; Thymine Nucleotides | 1982 |
Methionine metabolism in Walker carcinosarcoma in vitro.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma 256, Walker; Cell Survival; Cells, Cultured; Homocysteine; Methionine; Methotrexate; Sulfhydryl Compounds; Thymidine | 1980 |
Modification of in vivo methotrexate antitumor effect in L1210 leukemia by induced impairment of purine salvage.
Topics: Animals; Cell Line; Cell Survival; Drug Resistance; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mutation; Purines; Thymidine | 1981 |
Failure of 5-fluorouracil and methotrexate to destroy the reproductive integrity of a human breast cancer cell line (MCF-7) growing in vitro.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Clone Cells; Deoxyuridine; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorouracil; Humans; Male; Methotrexate; Thymidine | 1981 |
Thymidine-dependent growth of Physarum polycephalum amoebae treated with methotrexate in axenic culture.
Topics: Bromodeoxyuridine; Culture Media; Methotrexate; Physarum; Thymidine | 1981 |
Achievement of long duration methotrexate exposure with concurrent low dose thymidine protection: influence of methotrexate pharmacokinetics.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Administration Schedule; Drug Combinations; Drug Evaluation; Female; Half-Life; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine; Time Factors | 1980 |
Significance of variation in serum thymidine concentration for the marrow toxicity of methotrexate.
Topics: Blood Proteins; Bone Marrow Diseases; Colony-Forming Units Assay; Humans; Methotrexate; Protein Binding; Thymidine | 1981 |
Selection of mammalian thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate.
Topics: Animals; Cell Division; Cell Line; Female; Kinetics; Mammary Neoplasms, Experimental; Methotrexate; Methylnitronitrosoguanidine; Methyltransferases; Mice; Mice, Inbred C3H; Mutation; Thymidine; Thymidylate Synthase | 1981 |
Methotrexate with thymidine, inosine, and allopurinol rescue: a phase I clinical study.
Topics: Adult; Aged; Allopurinol; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypoxanthines; Infusions, Parenteral; Inosine; Male; Methotrexate; Middle Aged; Thymidine; Uric Acid | 1981 |
An antifolate-induced lesion in newly synthesized DNA.
Topics: Cell Line; Cell Survival; Deoxyuridine; DNA; Folic Acid Antagonists; Humans; Methotrexate; Molecular Weight; Pyrimethamine; Thymidine | 1980 |
Thymidine requirements for the rescue of patients treated with high-dose methotrexate.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Methotrexate; Thymidine; Uric Acid | 1980 |
Modulation of methotrexate toxicity by thymidine: sequence-dependent biochemical effects.
Topics: Animals; Cell Line; Cells, Cultured; Fibroblasts; Liver Neoplasms, Experimental; Lymphocytes; Methotrexate; Rats; Thymidine; Time Factors | 1980 |
Peritoneal exudate mononuclear phagocyte colony-forming cells: their proliferative state in vivo and sensitivity to cytotoxic agents.
Topics: Animals; Ascitic Fluid; Autoradiography; Carmustine; Cell Division; Colony-Forming Units Assay; Cyclophosphamide; Cytarabine; Female; Hematopoietic Stem Cells; Macrophages; Male; Mechlorethamine; Methotrexate; Mice; Mice, Inbred C3H; Thymidine; Tritium; Vinblastine | 1980 |
Synthesis of DNA as shown by the deoxyuridine suppression test is normal in the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus).
Topics: Animals; Bone Marrow; Cells, Cultured; Chiroptera; Deoxyuridine; DNA; Folic Acid; Lymphocytes; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.
Topics: Adenosine Triphosphate; Animals; Chlamydia trachomatis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; Guanosine Triphosphate; L Cells; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Phenotype; RNA, Bacterial; Sulfisoxazole; Thymidine; Trimethoprim; Uracil; Zidovudine | 1994 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro.
Topics: Animals; Cryopreservation; Freezing; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidine; Tumor Cells, Cultured | 1995 |
UVB-induced calmodulin increase in pig epidermis: analysis of the effect of the calmodulin antagonist, W-13.
Topics: Animals; Calmodulin; Cell Division; Epidermis; In Vitro Techniques; Keratinocytes; Kinetics; Methotrexate; Sulfonamides; Swine; Thymidine; Ultraviolet Rays | 1995 |
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; KB Cells; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1995 |
Cobalamin-dependent metabolism in chronic myelogenous leukemia determined by deoxyuridine suppression test and the formiminoglutamic acid and methylmalonate excretion in urine.
Topics: Adolescent; Adult; Aged; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Female; Formiminoglutamic Acid; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Malonates; Methotrexate; Middle Aged; Tetrahydrofolates; Thymidine; Tritium; Vitamin B 12 | 1995 |
Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation.
Topics: Blotting, Northern; Cell Division; Cell Line; Dimethyl Sulfoxide; gamma-Glutamyl Hydrolase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia, Promyelocytic, Acute; Methotrexate; Peptide Synthases; Pteroylpolyglutamic Acids; RNA, Messenger; Thymidine; Time Factors; Tumor Cells, Cultured | 1995 |
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations.
Topics: Antineoplastic Agents; Carcinoma; Cell Division; Colonic Neoplasms; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Thymidine; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1994 |
Reversal of methotrexate-induced folate pool depletion by thymidine in a human leukemia cell line in vitro.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Fluorescent Antibody Technique; Folic Acid; Humans; Interferon-gamma; Leukemia, Myeloid; Methotrexate; Thymidine; Tumor Cells, Cultured | 1993 |
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Hypoxanthines; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
5-Fluorouracil metabolism and cytotoxicity after pre-treatment with methotrexate or thymidine in human hypopharynx and colon carcinoma xenografts: a 19F-nuclear magnetic resonance spectroscopy study in vivo.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Fluorine Radioisotopes; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Nude; Pharyngeal Neoplasms; Thymidine; Transplantation, Heterologous | 1996 |
Circadian variation of DNA replication in hamster cheek pouch epithelium analysed by tritiated thymidine labelling, flow sorting and autoradiography: no resting S phase cells in the normal epithelium.
Topics: Animals; Cell Cycle; Cell Nucleus; Circadian Rhythm; Cricetinae; DNA Replication; Epithelial Cells; Flow Cytometry; Male; Mesocricetus; Methotrexate; Thymidine | 1996 |
Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10-deazaaminopterin (10-EDAM) against human lung cancer cell lines.
Topics: Aminopterin; Biological Transport; Cell Division; Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid Antagonists; Growth Inhibitors; Humans; Lung Neoplasms; Methotrexate; Nucleosides; Thymidine; Tumor Cells, Cultured | 1996 |
Cell proliferation as a predictor of response to chemotherapy in metastatic breast cancer: a prospective study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasm Metastasis; Prognosis; Prospective Studies; Thymidine; Tumor Cells, Cultured | 1997 |
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
Topics: Adolescent; Adult; Antidotes; Antimetabolites, Antineoplastic; Carboxypeptidases; Child; Child, Preschool; Female; Humans; Infant; Kidney; Kidney Diseases; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Thymidine | 1997 |
Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells.
Topics: Antigens, Polyomavirus Transforming; Cell Division; Cell Line, Transformed; Cell Transformation, Viral; Clone Cells; Dexamethasone; DNA; Fibroblasts; Gene Deletion; Glucocorticoids; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Methotrexate; Multigene Family; Recombination, Genetic; RNA, Messenger; Simian virus 40; Thymidine | 1997 |
Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants.
Topics: Aminopterin; Animals; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Gene Expression; Genetic Variation; Growth Inhibitors; Humans; Kinetics; Methotrexate; Pyrimidines; Rabbits; Tetrahydrofolate Dehydrogenase; Thymidine; Transfection; Trimetrexate | 1997 |
Effect of methotrexate on cell proliferation in developing hamster molar tooth germs in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Child; Cricetinae; Culture Media, Serum-Free; Humans; In Vitro Techniques; Methotrexate; Molar; Thymidine; Tooth Germ | 1998 |
Random population-wide genetic damage induced in replicating cells treated with methotrexate.
Topics: 3T3 Cells; Adenine; Animals; Antimetabolites, Antineoplastic; Cell Cycle; Culture Media; DNA Damage; Folic Acid Antagonists; Hypoxanthine; Methotrexate; Mice; Mutagenicity Tests; Thymidine | 1998 |
Thermotolerance inhibits various stress-induced apoptosis in NIH3T3 cells.
Topics: 3T3 Cells; Actins; Animals; Antimetabolites, Antineoplastic; Apoptosis; Autoradiography; Blotting, Western; Cell Survival; Diamide; DNA; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Methotrexate; Mice; Stress, Physiological; Sulfhydryl Reagents; Thymidine | 1998 |
Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity.
Topics: Antimetabolites, Antineoplastic; Carrier Proteins; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Gene Transfer Techniques; Humans; Methotrexate; Receptors, Cell Surface; Thymidine; Thymidine Kinase; Uterine Cervical Neoplasms; Zidovudine | 1999 |
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Topics: Cell Cycle; Cell Division; Culture Media; Drug Resistance; Enzyme Inhibitors; Fetal Blood; Head and Neck Neoplasms; Humans; Hypoxanthine; Inhibitory Concentration 50; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Child; Guanine; Humans; Inosine; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
Topics: Animals; CD8-Positive T-Lymphocytes; Clonal Deletion; Enterotoxins; Fas Ligand Protein; fas Receptor; Folic Acid Antagonists; Growth Inhibitors; Injections, Intraperitoneal; Injections, Intravenous; Ligands; Lymphocyte Activation; Lymphocyte Depletion; Membrane Glycoproteins; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Nucleic Acid Synthesis Inhibitors; Quinazolines; Staphylococcus aureus; Superantigens; T-Lymphocyte Subsets; Thiophenes; Thymidine; Thymidylate Synthase | 2001 |
Thymidine utilization abnormality in proliferating lymphocytes and hepatocytes of the woodchuck.
Topics: 3T3 Cells; Adenine; Animals; Blotting, Northern; Blotting, Southern; Cell Division; Humans; Liver; Lymphocytes; Marmota; Methotrexate; Mice; Models, Biological; Serine; Thymidine; Thymidine Kinase; Thymidine Monophosphate | 2001 |
Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Brain Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Lymphoma; Methotrexate; Middle Aged; Thymidine | 2001 |
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Base Sequence; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Folic Acid Antagonists; Gene Expression; Genes, Reporter; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; Jurkat Cells; Leucovorin; Methotrexate; NF-kappa B; NF-KappaB Inhibitor alpha; Oligodeoxyribonucleotides; Phosphorylation; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2B; Theobromine; Thymidine; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; U937 Cells | 2001 |
Lymphoblasts already in the DNA synthesis phase of the cell cycle can be reversibly arrested at the R/G transition.
Topics: Bromodeoxyuridine; Cell Cycle; Cell Line, Transformed; Chromosome Banding; Chromosomes, Human; DNA; DNA Replication; Flow Cytometry; Fluorouracil; Humans; Karyotyping; Kinetics; Lymphocyte Activation; Lymphocytes; Methotrexate; Mimosine; S Phase; Thymidine | 2001 |
Ribonucleotide reductase and thymidine phosphorylation: two potential targets of azodicarbonamide.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Drug Interactions; Hydroxyurea; Immunosuppressive Agents; Methotrexate; Phosphorylation; Ribonucleotide Reductases; Thymidine; Thymine Nucleotides; Tumor Cells, Cultured | 2002 |
Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Bone Neoplasms; Cattle; Culture Media; Cytarabine; Dialysis; Dipyridamole; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Fetal Blood; Humans; Hypoxanthine; Methotrexate; Neoplasm Proteins; Nucleotides; Osteosarcoma; Tetrahydrofolate Dehydrogenase; Thymidine; Tumor Cells, Cultured; Vidarabine | 2002 |
Biochemical studies of the division cycle of mammalian cells: evidence for the premitotic period.
Topics: Animals; Cell Division; DNA; DNA, Neoplasm; Glycine; Humans; Mast Cells; Methotrexate; Neoplasms; Neoplasms, Experimental; Thymidine; Xanthines | 1963 |
THE CLINICAL EFFECTS OF THE CONTINUOUS INTRAVENOUS INFUSION OF CANCER CHEMOTHERAPEUTIC COMPOUNDS.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Floxuridine; Fluorouracil; Infusions, Intravenous; Infusions, Parenteral; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Thymidine | 1964 |
[INFLUENCING THE CELL DIVISION CYCLE IN CELL CULTURES BY VARIATION OF THE CULTURE MEDIUM].
Topics: Cell Division; Culture Media; DNA; Glycine; Leucine; Methotrexate; Purines; Thymidine; Thymine; Tissue Culture Techniques | 1964 |
THE PARTICIPATION OF DNA IN ROUS SARCOMA VIRUS PRODUCTION.
Topics: Avian Sarcoma Viruses; Chick Embryo; Dactinomycin; DNA; DNA, Viral; Fibroblasts; Metabolism; Methotrexate; Mice; Pharmacology; Radiometry; Research; RNA; RNA, Viral; Rous sarcoma virus; Thymidine; Tissue Culture Techniques; Tritium; Uridine; Virus Cultivation | 1964 |
THE UTILIZATION OF METHOTREXATE, AMINOPTERIN, SPLEEN HEMOGENATE, THYMUS HEMOGENATE, AND DNA AS TEST AGENTS FOR SUPPRESSION OF DNA SYNTHESIS IN REGENERATING RAT LIVER.
Topics: Aminopterin; DNA; Hepatectomy; Liver Diseases; Liver Regeneration; Metabolism; Methotrexate; Pharmacology; Rats; Research; Spleen; Thymidine; Thymus Gland; Tissue Extracts; Tritium | 1964 |
COMBINATION OF SURGERY AND CHEMOTHERAPY IN THE TREATMENT OF ORAL CANCER.
Topics: DNA; DNA, Neoplasm; Drug Therapy; Fluorouracil; Humans; Methotrexate; Mouth Neoplasms; Neck Dissection; Neoplasms; Surgical Procedures, Operative; Thymidine | 1964 |
REPLICATION OF A DEOXYRIBONUCLEIC ACID VIRUS IN THYMINE-DEFICIENT MAMMALIAN CELLS.
Topics: Animals; DNA; DNA Replication; DNA, Viral; Female; Floxuridine; Horses; Methotrexate; Nucleotides; Pharmacology; Pregnancy; Research; Thymidine; Thymine; Tissue Culture Techniques; Vertebrates; Virus Cultivation; Virus Replication; Viruses | 1964 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. II. THYMIDINE UPTAKE IN SUSPENSION CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; DNA; DNA, Neoplasm; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Neoplasms, Experimental; Pharmacology; Pyrimidines; Radiometry; Rats; Research; Thymidine; Tritium | 1965 |
ACUTE EFFECTS OF CYTOTOXIC COMPOUNDS ON INCORPORATION OF PRECURSORS INTO DNA, RNA, AND PROTEIN OF HELA MONOLAYERS.
Topics: Anti-Bacterial Agents; Antimetabolites; Dactinomycin; DNA; Floxuridine; HeLa Cells; Humans; Leucine; Mercaptopurine; Metabolism; Methotrexate; Nucleosides; Pharmacology; Proteins; Puromycin; Research; RNA; Streptonigrin; Thymidine; Tissue Culture Techniques; Triethylenemelamine; Urethane; Uridine; Vinblastine | 1965 |
A fluorine-labeled methotrexate as a probe for monitoring tumor antifolate pharmacokinetics: synthesis, in vitro cytotoxicity, and pilot in vivo 19F magnetic resonance spectra.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Dose-Response Relationship, Drug; Fluorine Radioisotopes; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Models, Chemical; Models, Molecular; Neoplasm Transplantation; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thymidine; Time Factors | 2003 |
Thymidine rescue: an antidote for pemetrexed-related toxicity in the setting of acute renal failure.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Cisplatin; Drug Therapy, Combination; Humans; Lung Neoplasms; Male; Mesothelioma; Methotrexate; Middle Aged; Thymidine | 2003 |
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Topics: Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Stability; Fibrosarcoma; Folic Acid Antagonists; Humans; Methotrexate; Neoplastic Stem Cells; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2004 |
Persistent nicotine treatment potentiates amplification of the dihydrofolate reductase gene in rat lung epithelial cells as a consequence of Ras activation.
Topics: Agar; Animals; Blotting, Southern; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin D1; DNA Damage; Drug Resistance; Enzyme Activation; Epithelial Cells; Flow Cytometry; G1 Phase; Ganglionic Stimulants; Hydrogen Peroxide; Immunoblotting; Lung; Methotrexate; Nicotine; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Protein Kinase C; ras Proteins; Rats; Reactive Oxygen Species; Signal Transduction; Tetrahydrofolate Dehydrogenase; Thymidine; Time Factors; Tumor Suppressor Protein p53 | 2005 |
Effect of nucleoside transport inhibitors on thymidine salvage and the toxicity of nucleoside analogs in mouse bone marrow granulocyte-macrophage progenitor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Bone Marrow Cells; Cells, Cultured; Cladribine; Female; Granulocytes; Hematopoietic Stem Cells; Macrophages; Methotrexate; Mice; Mice, Inbred CBA; Nucleoside Transport Proteins; Thioinosine; Thymidine; Tubercidin | 1991 |
Cell-cycle-dependent pharmacology of methotrexate in HL-60.
Topics: Antimetabolites, Antineoplastic; Blotting, Northern; Cell Cycle; Cell Proliferation; Folic Acid Antagonists; HL-60 Cells; Humans; Methotrexate; RNA, Messenger; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase; Thymidine | 2005 |
In vivo analysis of Drosophila deoxyribonucleoside kinase function in cell cycle, cell survival and anti-cancer drugs resistance.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Cycle; Cell Proliferation; Cell Survival; Drosophila melanogaster; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Gene Expression Regulation; Methotrexate; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Thymidine | 2006 |
Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.
Topics: Adenocarcinoma; Adenosine; Alkaline Phosphatase; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Proliferation; Colonic Neoplasms; Cyclic AMP; Extracellular Signal-Regulated MAP Kinases; HT29 Cells; Humans; Hypoxanthines; MAP Kinase Kinase Kinases; Methionine; Methotrexate; Phosphatidylinositol 3-Kinases; Polyamines; Purines; Signal Transduction; Tetrahydrofolates; Thymidine | 2006 |
[Management recommendations in patients with methotrexate intoxication].
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Female; Humans; Kidney; Leucovorin; Lymphoma; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Renal Insufficiency; Thymidine; Vitamin B Complex | 2007 |
Medroxyprogesterone acetate induces c6 glioma chemosensitization via antidepressant-like lysosomal phospholipidosis/myelinosis in vitro.
Topics: Animals; Antidepressive Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Nucleus; Cisplatin; Drug Resistance, Neoplasm; Glioma; In Vitro Techniques; Lysosomes; Medroxyprogesterone Acetate; Methotrexate; Microscopy, Electron; Myelin Sheath; Phospholipids; S Phase; Thymidine; Tumor Stem Cell Assay | 2007 |
Case files of the New York City Poison Control Center: antidotal strategies for the management of methotrexate toxicity.
Topics: Antidotes; Antimetabolites, Antineoplastic; Child; Fluid Therapy; Folic Acid; gamma-Glutamyl Hydrolase; Hemoperfusion; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; New York City; Poison Control Centers; Poisoning; Renal Dialysis; Thymidine; Treatment Outcome; Vitamin B Complex | 2008 |
High-performance capillary electrophoretic method for the quantification of global DNA methylation: application to methotrexate-resistant cells.
Topics: Deoxyadenosines; Deoxycytidine; Deoxyguanosine; DNA Methylation; Drug Resistance, Neoplasm; Electrophoresis, Capillary; Humans; Methotrexate; Reproducibility of Results; Thymidine | 2009 |
Evaluation of a range of anti-proliferative assays for the preclinical screening of anti-psoriatic drugs: a comparison of colorimetric and fluorimetric assays with the thymidine incorporation assay.
Topics: Anthralin; Anti-Infective Agents, Local; Caspase 3; Caspase 7; Cell Line; Cell Proliferation; Colorimetry; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fluorescent Dyes; Fluorometry; Humans; Keratinocytes; Methotrexate; Psoriasis; Reproducibility of Results; Tetrazolium Salts; Thiazoles; Thymidine | 2010 |
Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combination; Female; gamma-Glutamyl Hydrolase; Humans; Infant; Kidney Diseases; Leucovorin; Male; Methotrexate; Middle Aged; Thymidine | 2010 |
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Dideoxynucleosides; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Fluorouracil; HCT116 Cells; Humans; Immunoblotting; Ki-67 Antigen; Methotrexate; Mice; Mice, Nude; Organophosphates; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Thymidine; Thymidine Kinase; Xenograft Model Antitumor Assays | 2011 |
Immunomodulatory effect of sertraline in a rat model of rheumatoid arthritis.
Topics: Analysis of Variance; Animals; Arthritis, Rheumatoid; Concanavalin A; Cyclooxygenase 2; Cytokines; Cytotoxicity Tests, Immunologic; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Immunologic Factors; Methotrexate; Rats; Rats, Inbred Lew; Sertraline; Spleen; Thymidine | 2012 |
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue Virus; Disease Models, Animal; DNA Viruses; Flavivirus; Flavivirus Infections; Floxuridine; HEK293 Cells; HeLa Cells; Humans; Leucovorin; Methotrexate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; RNA Viruses; Thymidine; Tumor Suppressor Protein p53; Vero Cells; Virus Replication; West Nile virus | 2013 |
Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells.
Topics: A549 Cells; Actins; Alveolar Epithelial Cells; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Cycle Checkpoints; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Humans; Methotrexate; Nocodazole; Paclitaxel; Thymidine | 2019 |