Page last updated: 2024-08-25

methotrexate and hydrogen carbonate

methotrexate has been researched along with hydrogen carbonate in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (52.63)	18.7374
1990's	4 (21.05)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (10.53)	24.3611
2020's	3 (15.79)	2.80

Authors

Authors	Studies
Gisolfi, AL; Mehta, BM; Mosende, C; Nirenberg, A; Rosen, G	1
Goldberg, NH; Hande, KR; Romolo, JL; Rosenberg, SA	1
Hirschfeld, S; Jarosinski, PF	1
Arfeen, S; Carey, PJ; Jackson, G; Proctor, SJ; Stark, AN	1
Christensen, ML; Crom, WR; Evans, WE; Hancock, ML; Rivera, GK	1
Alsarraf, D; Reese, L	1
Smith, ME	1
Maher, JF; Rath, CE; Schreiner, GE	1
Henschler, D; Herken, W; Rietbrock, N	1
Goto, M; Konishi, H; Tsuda, N; Yamashina, H	1
de Bruyn, C; Delespesse, G; Duchateau, J; Gausset, P; Kulakowski, S; Vamos, E	1
Arreguín, L; Benítez, H; Bernaldez, R; Díaz, S; Farfán, J; Gaona, A; Juan, L; Martínez, MC; Velásquez, L	1
Bacci, G; Cesari, M; Fasano, MC; Ferrari, S; Lamanna, G; Zolezzi, C	1
Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Qiu, Y; Richards, DF; Rückemann, K; Simmonds, HA; Swaminathan, R	1
Arradaza, NV; Brinker, BT; Campbell, AD; Frobish, D; Kintzel, PE; O'Rourke, TJ; Wehr, AM; Yost, KJ	1
Herbrecht, R; Jarfaut, A; Levêque, D; Santucci, R	1
Bryan, L; Chase, A; Clemmons, AB; Duong, P; Saunders, K; Waller, JL	1
Abedinzadegan Abdi, S; Fong, LG; Hawker, JL; Heisler, RD; Jupp, JC; Kelly, JJ; Quon, JL; Rioux, JZ	1
Al-Rahawan, MM; Ali, Z; Chyu, J	1

Trials

2 trial(s) available for methotrexate and hydrogen carbonate

Article	Year
High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity. Cancer treatment reports, 1977, Volume: 61, Issue:5 Topics: Bicarbonates; Drug Interactions; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Time Factors	1977
Prospective evaluation of high-dose ifosfamide-related nephrotoxicity in young adult patients with recurrent osteosarcoma previously treated with cisplatin, methotrexate and standard-dose ifosfamide. Anti-cancer drugs, 1999, Volume: 10, Issue:1 Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Bone Neoplasms; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Kidney; Kidney Diseases; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prospective Studies	1999

Article

Year

High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity.

Cancer treatment reports, 1977, Volume: 61, Issue:5

Topics: Bicarbonates; Drug Interactions; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Time Factors

1977

Prospective evaluation of high-dose ifosfamide-related nephrotoxicity in young adult patients with recurrent osteosarcoma previously treated with cisplatin, methotrexate and standard-dose ifosfamide.

Anti-cancer drugs, 1999, Volume: 10, Issue:1

Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Bone Neoplasms; Cisplatin; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Ifosfamide; Kidney; Kidney Diseases; Male; Methotrexate; Neoplasm Recurrence, Local; Osteosarcoma; Prospective Studies

1999

Other Studies

17 other study(ies) available for methotrexate and hydrogen carbonate

Article	Year
Effect of hydration on plasma-methotrexate levels. Cancer treatment reports, 1977, Volume: 61, Issue:7 Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Osteosarcoma; Sodium; Solutions; Water	1977
Precipitation of ondansetron in alkaline solutions. The New England journal of medicine, 1991, Oct-31, Volume: 325, Issue:18 Topics: Antiemetics; Bicarbonates; Chemical Precipitation; Drug Therapy, Combination; Hydrogen-Ion Concentration; Imidazoles; Methotrexate; Ondansetron; Sodium; Sodium Bicarbonate; Solutions	1991
Severe renal toxicity due to intermediate-dose methotrexate. Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:4 Topics: Adult; Aged; Back Pain; Bicarbonates; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Mouthwashes; Sodium; Sodium Bicarbonate; Stomatitis	1989
Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:5 Topics: Bicarbonates; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Leukemia, Lymphoid; Methotrexate	1988
Management of acute renal failure due to marked hyperuricemia. Canadian Medical Association journal, 1972, Feb-19, Volume: 106, Issue:4 Topics: Acute Kidney Injury; Adolescent; Allopurinol; Bicarbonates; Humans; Infusions, Parenteral; Kidney; Leukemia, Lymphoid; Male; Methotrexate; Potassium; Prednisone; Radiography; Regional Blood Flow; Renal Dialysis; Sodium; Thrombocytopenia; Uric Acid; Vincristine	1972
The uptake of pteroylglutamic acid by the rat jejunum. Biochimica et biophysica acta, 1973, Feb-27, Volume: 298, Issue:1 Topics: Animals; Bicarbonates; Biological Transport; Buffers; Diffusion; Fluorides; Folic Acid; Glucose; Intestinal Mucosa; Jejunum; Male; Methotrexate; Phosphates; Rats; Tritium	1973
Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis. Archives of internal medicine, 1969, Volume: 123, Issue:2 Topics: Acetazolamide; Acute Kidney Injury; Adult; Allopurinol; Anuria; Bicarbonates; Blood Gas Analysis; Blood Urea Nitrogen; Carbon Dioxide; Cystoscopy; Electroencephalography; Eye Manifestations; Female; Humans; Leukemia, Lymphoid; Leukocytosis; Mannitol; Mercaptopurine; Methotrexate; Peritoneal Dialysis; Prednisone; Splenomegaly; Thrombocytopenia; Uric Acid; Urinary Catheterization; Vincristine; Water-Electrolyte Balance	1969
[Effect of Tris buffer (THAM) and sodium bicarbonate on the metabolic acidosis of methanol poisoning in dogs]. Archiv fur Toxikologie, 1969, Volume: 24, Issue:2 Topics: Acid-Base Equilibrium; Acidosis; Animals; Bicarbonates; Dogs; Formates; Methanol; Methotrexate; Tromethamine	1969
[Effect of IV hydration with sodium bicarbonate on high-dose methotrexate disposition kinetics]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:4 Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Kinetics; Leukemia, Myeloid, Acute; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms; Osteosarcoma; Sodium Bicarbonate	1984
Differential responses to mitogen stimulation in lymphocytes from normal individuals and Lesch-Nyhan patients: influence of the bicarbonate buffer system. Clinical and experimental immunology, 1980, Volume: 42, Issue:2 Topics: Adolescent; Adult; B-Lymphocytes; Bicarbonates; Child; Humans; Lesch-Nyhan Syndrome; Lymphocyte Activation; Lymphocytes; Methotrexate; Mitogens; Streptodornase and Streptokinase; T-Lymphocytes	1980
[Electrolytic changes in children with acute lymphoblastic leukemia during remission induction]. Sangre, 1995, Volume: 40, Issue:3 Topics: Adolescent; Allopurinol; Anions; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Blood Urea Nitrogen; Cations; Child; Child, Preschool; Cohort Studies; Creatinine; Epirubicin; Female; Humans; Hydrocortisone; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Serum Albumin; Uric Acid; Vincristine; Water-Electrolyte Imbalance	1995
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis? The Biochemical journal, 1999, Aug-15, Volume: 342 ( Pt 1) Topics: Amidophosphoribosyltransferase; Arthritis, Rheumatoid; Bicarbonates; Cell Cycle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Humans; Hypoxanthine; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Nucleotides; Phosphoribosyl Pyrophosphate; Phytohemagglutinins; Protein Biosynthesis; Proteins; Purines; Pyrimidines; Ribonucleotides; T-Lymphocytes; Uridine	1999
Reduced time for urinary alkalinization before high-dose methotrexate with preadmission oral bicarbonate. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2012, Volume: 18, Issue:2 Topics: Acute Kidney Injury; Administration, Oral; Aged; Bicarbonates; Diagnostic Tests, Routine; Female; Humans; Length of Stay; Male; Methotrexate; Middle Aged; Retrospective Studies; Time Factors; Urinalysis	2012
Severe methotrexate toxicity due to a concomitant administration of ciprofloxacin. Medecine et maladies infectieuses, 2013, Volume: 43, Issue:1 Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bicarbonates; Bleomycin; Ciprofloxacin; Crystallization; Cyclophosphamide; Cytarabine; Diarrhea; Doxorubicin; Drug Eruptions; Drug Interactions; Etoposide; Female; Fluid Therapy; Fungemia; Humans; Hydrogen-Ion Concentration; Ifosfamide; Lymphoma, B-Cell; Mediastinal Neoplasms; Metabolic Clearance Rate; Methotrexate; Mucositis; Pancytopenia; Prednisone; Solubility; Urine; Vindesine	2013
Assessing the impact of adding acetazolamide to oral or intravenous sodium bicarbonate as compared with intravenous bicarbonate monotherapy as urinary alkalinization in adults receiving high-dose methotrexate. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021, Volume: 29, Issue:3 Topics: Acetazolamide; Administration, Intravenous; Administration, Oral; Bicarbonates; Female; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies; Sodium Bicarbonate; Urine	2021
Evaluation of an oral sodium bicarbonate protocol for high-dose methotrexate urine alkalinization. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:2 Topics: Administration, Intravenous; Adult; Bicarbonates; Humans; Methotrexate; Retrospective Studies; Sodium Bicarbonate	2022
Comments on evaluation of an oral sodium bicarbonate protocol for high-dose methotrexate urine alkalinization. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:12 Topics: Acute Kidney Injury; Bicarbonates; Humans; Methotrexate; Retrospective Studies; Sodium Bicarbonate	2022