methotrexate has been researched along with edatrexate in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (16.28) | 18.7374 |
| 1990's | 33 (76.74) | 18.2507 |
| 2000's | 2 (4.65) | 29.6817 |
| 2010's | 1 (2.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, A; Galivan, J; Gaumont, Y; Kisliuk, RL; McGuire, JJ; Nair, MG; Nimec, Z | 1 |
| Christie, PH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sirotnak, FM | 1 |
| Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG; Nanavati, NT | 1 |
| Bader, H; Keyomarsi, K; Matherly, LH; Rosowsky, A; Wright, JE | 1 |
| Iijima, A; Kitoh, K; Kotake, Y; Koyanagi, N; Nomura, H; Ozawa, Y; Tamai, N; Yoshimatsu, K | 1 |
| Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM | 2 |
| Colwell, WT; Crase, J; DeGraw, JI; Piper, JR; Sirotnak, FM; Smith, RL; Waud, WR | 1 |
| Boesche, M; Crowther, GJ; Dasari, KS; Drewes, G; El Bakkouri, M; Fox, AM; Ghidelli-Disse, S; He, P; Hillesland, HK; Hui, R; Jones, JC; Keyloun, KR; Krahn, MM; Lafuente-Monasterio, MJ; Leonard, SE; Leroy, D; Maly, DJ; Mo, JS; Ojo, KK; Reid, MC; Rivas, KL; Van Voorhis, WC | 1 |
| Bertino, JR; Brennan, MF; Li, WW; Lin, JT; Tong, WP; Trippett, TM | 1 |
| Yoshimura, A | 1 |
| Hordijk, GJ; Jansen, G; Kathmann, GA; Schornagel, JH; van der Laan, BF; Westerhof, GR | 1 |
| Bertino, JR; Li, WW; Lin, JT; Schweitzer, BI | 1 |
| Bertino, JR; Chang, YM; Li, WW; Lin, JT; Schweitzer, B | 1 |
| Braakhuis, BJ; Brown, DH; Snow, GB; Van Dongen, GA | 1 |
| Otter, GM; Rumberger, BG; Schmid, FA; Sirotnak, FM | 1 |
| Freisheim, JH; Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG | 1 |
| DeGraw, JI; Schmid, FA; Sirotnak, FM | 1 |
| Christie, PH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Schmid, FA; Sirotnak, FM; Tagawa, H | 1 |
| Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| DeGraw, JI; Goutas, LJ; Moccio, DM; Schmid, FA; Sirotnak, FM | 1 |
| Braakhuis, BJ; Jansen, G; Kegel, A; Noordhuis, P; Peters, GJ | 1 |
| Jansen, G; Jolivet, J; Peters, GJ; Pinard, MF; Schornagel, JH | 1 |
| Armand, JP; Cappelaere, P; Clavel, M; Cognetti, F; de Graeff, A; de Mulder, PH; Schornagel, JH; Vermorken, JB; Verweij, J; Wildiers, J | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR | 1 |
| Ramos-Remus, C; Russell, AS; Skeith, KJ | 1 |
| Tsukagoshi, S | 2 |
| Bergoltz, VV; Bolanowska, WE; Haile, WH; Haneda, T; Heitzman, KJ; Kotake, Y; McGuire, JJ; Nomura, H; Russell, CA | 1 |
| Braakhuis, BJ; Jansen, G; Peters, GJ | 1 |
| Jansen, G; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR | 1 |
| Chou, TC; Sirotnak, FM; Tan, QH | 1 |
| Otter, GM; Schmid, FA; Sirotnak, FM | 1 |
| Perez, EA | 1 |
| Jansen, G; Jolivet, J; Kathmann, I; Molthoff, C; Pinard, MF; Ratnam, M; Schornagel, JH; Westerhof, R | 1 |
| Anderson, M; Chu, E; Dearing, MP; Englee-Miller, MJ; Gazdar, AF; Kramer, BS; Kratzke, RA; Mulshine, JL; Venzon, D; Weinstein, J | 1 |
| Pizzorno, G; Rayl, EA | 1 |
| Chatterjee, DJ; Koda, RT; Li, WY | 1 |
| Blakley, RL; Lewis, WS; Mareya, SM; Patel, M; Sleep, SE; Sorrentino, BP; Spencer, HT | 1 |
| Aghi, M; Breakefield, XO; Kramm, CM | 1 |
| Strømhaug, A; Warren, DJ | 1 |
| Barrueco, JR; Dawson, MI; Hobbs, PD; O'Krongly, D; Sirotnak, FM | 1 |
| Khokhar, NZ; Rusch, VW; She, Y; Sirotnak, FM | 1 |
4 review(s) available for methotrexate and edatrexate
| Article | Year |
|---|---|
[New analogues of methotrexate].
Topics: Aminopterin; Animals; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Methotrexate; Trimetrexate | 1992 |
[Recent development of new anticancer drugs in Japan].
Topics: Aminopterin; Antineoplastic Agents; Camptothecin; Cisplatin; Cytarabine; Irinotecan; Methotrexate; Paclitaxel; Tretinoin; Tubulin Modulators; Vinblastine; Vinorelbine | 1993 |
[Development of antimetabolites, II].
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Humans; Leukemia L1210; Methotrexate; Mice; Trimetrexate | 1993 |
Antifolates: current developments.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Thymidylate Synthase | 1996 |
1 trial(s) available for methotrexate and edatrexate
| Article | Year |
|---|---|
Randomized phase III trial of edatrexate versus methotrexate in patients with metastatic and/or recurrent squamous cell carcinoma of the head and neck: a European Organization for Research and Treatment of Cancer Head and Neck Cancer Cooperative Group stu
Topics: Agranulocytosis; Aminopterin; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Head and Neck Neoplasms; Humans; Injections, Intravenous; Lung; Male; Methotrexate; Respiratory Distress Syndrome; Thrombocytopenia | 1995 |
38 other study(ies) available for methotrexate and edatrexate
| Article | Year |
|---|---|
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Indicators and Reagents; Methotrexate; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship | 1991 |
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.
Topics: Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Methotrexate; Molecular Structure; Tumor Cells, Cultured | 1990 |
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
Topics: Aminopterin; Animals; Anti-Bacterial Agents; Female; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Lacticaseibacillus casei; Methotrexate; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Peptides; Polyglutamic Acid; Streptococcus; Structure-Activity Relationship; Substrate Specificity | 1988 |
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Folic Acid Antagonists; Humans; Methotrexate; Mice; Ornithine; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Colonic Neoplasms; Folic Acid Antagonists; Glutamates; Humans; Leukemia P388; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Female; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Structure-Activity Relationship | 1993 |
Analogues of methotrexate in rheumatoid arthritis. 1. Effects of 10-deazaaminopterin analogues on type II collagen-induced arthritis in mice.
Topics: Aminopterin; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Line; Cell Survival; Collagen; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methotrexate; Mice; Molecular Structure; Tumor Cells, Cultured | 1997 |
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
Topics: Antimalarials; Calcium; Cell Line, Tumor; Hep G2 Cells; Humans; Malaria, Falciparum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Plasmodium falciparum; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protozoan Proteins | 2016 |
Mechanisms of natural resistance to antifolates in human soft tissue sarcomas.
Topics: Aminopterin; Chromatography, High Pressure Liquid; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Peptide Synthases; Polyglutamic Acid; Sarcoma; Soft Tissue Neoplasms; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimetrexate; Tumor Stem Cell Assay | 1992 |
In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate.
Topics: Aminopterin; Biological Transport; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cell Membrane; Drug Resistance; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tumor Cells, Cultured | 1992 |
Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
Topics: Aminopterin; Animals; Drug Resistance; Folic Acid Antagonists; Leucovorin; Methotrexate; Methylcholanthrene; Polyglutamic Acid; Rats; Sarcoma, Experimental; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured | 1991 |
Prediction of antifolate efficacy in a rat sarcoma model.
Topics: Aminopterin; Animals; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Male; Methotrexate; Methylcholanthrene; Quinazolines; Rats; Sarcoma, Experimental; Thymidylate Synthase; Trimetrexate | 1991 |
Comparative study of the sensitivity of head and neck cell lines to methotrexate (MTX) and the analog 10-ethyl, 10-deazaaminopterin (10-EdAM).
Topics: Aminopterin; Carcinoma, Squamous Cell; Cell Line; Folic Acid Antagonists; Head and Neck Neoplasms; In Vitro Techniques; Methotrexate; Tumor Cells, Cultured | 1990 |
Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.
Topics: Aminopterin; Animals; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Peptide Synthases; Phenotype | 1990 |
Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.
Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Peptides; Polyglutamic Acid | 1989 |
Intracavitary therapy of murine ovarian cancer with cis-diamminedichloroplatinum(II) and 10-ethyl-10-deazaaminopterin incorporating systemic leucovorin protection.
Topics: Aminopterin; Animals; Cisplatin; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Injections, Intraperitoneal; Injections, Subcutaneous; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred C3H; Ovarian Neoplasms | 1989 |
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.
Topics: Aminopterin; Animals; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Stereoisomerism; Structure-Activity Relationship | 1986 |
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay | 1985 |
New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models.
Topics: Aminopterin; Animals; Drug Evaluation, Preclinical; Female; Methotrexate; Mice; Neoplasms, Experimental; Structure-Activity Relationship | 1984 |
Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma.
Topics: Aminopterin; Carcinoma, Squamous Cell; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Methotrexate; Polyglutamic Acid; Tumor Cells, Cultured | 1993 |
Leucovorin rescue of human cancer and bone marrow cells following edatrexate or methotrexate.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Division; Folic Acid; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Tumor Cells, Cultured | 1994 |
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Topics: Aminopterin; Animals; Carrier Proteins; Cell Division; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Haplorhini; Humans; Kidney; Leucovorin; Methotrexate; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Quinazolines; Receptors, Cell Surface; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1995 |
Comparative efficacy and toxicity of 10-ethyl-10-deazaaminopterin and methotrexate in a mycobacterial rat arthritis model.
Topics: Aminopterin; Animals; Arthritis, Experimental; Drug Evaluation, Preclinical; Female; Intestinal Diseases; Methotrexate; Nontuberculous Mycobacteria; Peritonitis; Rats; Rats, Inbred Lew; Stomatitis | 1994 |
Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
Topics: Aminopterin; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamate Synthase; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Variable pharmacodynamics of antifolates in squamous cell carcinoma of the head and neck.
Topics: Aminopterin; Carcinoma, Squamous Cell; Cell Division; Cell Line; Drug Resistance; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Methotrexate; Tumor Cells, Cultured | 1993 |
Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein.
Topics: Aminopterin; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Kinetics; Leucovorin; Methotrexate; Quinazolines; Receptors, Cell Surface; Structure-Activity Relationship | 1993 |
Quantitation of the synergistic interaction of edatrexate and cisplatin in vitro.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Cisplatin; Computer Simulation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Methotrexate; Tumor Cells, Cultured | 1993 |
Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.
Topics: Adenocarcinoma; Aminopterin; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibrosarcoma; Leucovorin; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Salvage Therapy | 1993 |
Schedule-dependent edatrexate toxicity.
Topics: Aminopterin; Antineoplastic Agents; Drug Administration Schedule; Head and Neck Neoplasms; Humans; Methotrexate; Mouth Mucosa; Palliative Care; Stomatitis | 1996 |
Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Binding Sites; Breast Neoplasms; Carrier Proteins; Cell Membrane; DNA, Complementary; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Polymerase Chain Reaction; Quinazolines; Receptors, Cell Surface; RNA, Messenger; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1996 |
Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10-deazaaminopterin (10-EDAM) against human lung cancer cell lines.
Topics: Aminopterin; Biological Transport; Cell Division; Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid Antagonists; Growth Inhibitors; Humans; Lung Neoplasms; Methotrexate; Nucleosides; Thymidine; Tumor Cells, Cultured | 1996 |
Effect of vehicles and penetration enhancers on the in vitro and in vivo percutaneous absorption of methotrexate and edatrexate through hairless mouse skin.
Topics: Administration, Cutaneous; Aminopterin; Animals; Antirheumatic Agents; Azepines; Caprylates; In Vitro Techniques; Methotrexate; Mice; Mice, Hairless; Permeability; Pharmaceutical Vehicles; Skin Absorption; Solubility | 1997 |
Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants.
Topics: Aminopterin; Animals; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Gene Expression; Genetic Variation; Growth Inhibitors; Humans; Kinetics; Methotrexate; Pyrimidines; Rabbits; Tetrahydrofolate Dehydrogenase; Thymidine; Transfection; Trimetrexate | 1997 |
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Nude; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1998 |
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Chromatography, Thin Layer; Dogs; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Methotrexate; Neoplasms; Peptide Synthases; Rats; Transduction, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro.
Topics: Aminopterin; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Hematopoietic Stem Cells; Methotrexate; Mice; Mice, Inbred BALB C; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 2000 |
Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin.
Topics: Aminopterin; Antineoplastic Agents; Folic Acid Antagonists; Methotrexate; Oxidation-Reduction | 1987 |
Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums.
Topics: Adenosine Triphosphatases; Aminopterin; Animals; Anion Transport Proteins; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cell Cycle Proteins; Cell Division; Cisplatin; Drug Design; Fungal Proteins; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Mesothelioma; Methotrexate; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Platinum Compounds; Protein Isoforms; Protein Kinases; RNA, Neoplasm; Schizosaccharomyces pombe Proteins; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |