methotrexate has been researched along with dihydrofolate in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (35.29) | 18.7374 |
| 1990's | 15 (29.41) | 18.2507 |
| 2000's | 12 (23.53) | 29.6817 |
| 2010's | 6 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benkovic, SJ; Taira, K | 1 |
| Adams, J; Evenson, DA; McIvor, RS; Wagner, CR | 1 |
| Bayley, PM; Hood, K; Roberts, GC | 1 |
| White, JC | 1 |
| José, J; Manaut, F; Milesi, M; Sanz, F | 1 |
| Allegra, CJ; Boarman, D | 1 |
| Melera, PW | 1 |
| Freisheim, JH; Huang, SM; Ratnam, M; Tan, XH; Thompson, PD | 1 |
| Allegra, CJ; Baram, J; Boarman, DM | 1 |
| Allegra, CJ; Baram, J; Drake, JC | 1 |
| Baugh, CM; Gaumont, Y; Kaufman, BT; Kisliuk, RL; Kumar, P; Nair, MG | 1 |
| Balińska, M | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 1 |
| Hitchings, GH | 1 |
| Carpano, P; Cercignani, G; Degan, P; Montagnoli, G | 1 |
| Appleman, JR; Blakley, RL; Delcamp, TJ; Freisheim, JH; Prendergast, NJ | 1 |
| Balinska, M; Galivan, J; Kruger-McDermott, C | 1 |
| Webber, S; Whiteley, JM | 1 |
| Hendel, J; Nyfors, A; Nyfors, B; Poulsen, H | 1 |
| Bolard, J; Seng, G | 1 |
| Gaumont, Y; Kisliuk, RL; Nair, MG; North, G; Salter, OC | 1 |
| Bertino, JR; Fernandes, DJ; Mini, E | 1 |
| Cybulski, RL; Fisher, RR | 1 |
| Da Costa, M; Iqbal, MP; Rothenberg, SP | 1 |
| Biedler, JL; Hession, C; Lewis, JA; Melera, PW | 1 |
| Itai, A; Mizutani, MY; Tomioka, N | 1 |
| Appleman, JR; Blakley, RL; Nakano, T; Spencer, HT | 1 |
| Appleman, JR; Blakley, RL; Chunduru, SK; Harris, SE; Lewis, WS; Nakano, T | 1 |
| Appleman, JR; Blakley, RL; Nakano, T | 1 |
| Allegra, CJ; Chu, E; Grem, JL; Takimoto, CH; Voeller, D | 1 |
| Huennekens, FM | 1 |
| Lemmen, C; Lengauer, T | 1 |
| Honscha, W; Petzinger, E | 1 |
| Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ | 1 |
| Feher, M; Labute, P; Schmidt, JM; Sourial, E; Williams, C | 1 |
| Horn, H; Huber, WK; Krämer, A; Pitman, MC; Rice, JE; Swope, WC | 1 |
| Akhurst, T; Balatoni, J; Banerjee, D; Bertino, JR; Blasberg, R; Bornmann, W; Doubrovin, M; Finn, R; Fong, Y; Gelovani Tjuvajev, J; Iwamoto, M; Larson, S; Malhotra, S; Mayer-Kuckuk, P | 1 |
| Schröder, O; Stein, J | 1 |
| Budu, P; Nijhout, HF; Reed, MC; Ulrich, CM | 1 |
| Ainavarapu, SR; Badilla, CL; Fernandez, JM; Li, L | 1 |
| Carson, M; Chattopadhyay, D; Delucas, L; Howard, A; Pal, B; Schormann, N; Senkovich, O; Smith, C | 1 |
| Basset, G; Hanson, AD; Nichols, BP; Ravanel, S; Rébeillé, F; Sahr, T | 1 |
| Ainavarapu, SR; Fernandez, JM; Li, L | 1 |
| Essex, JW; Ford, MG; Hudson, BD; Swain, M; Whitley, DC | 1 |
| Manallack, DT | 1 |
| Coward, JK; Hyde, JE; Nzila, A; Sims, PF; Wang, P; Wang, Q; Yang, Y | 1 |
| Kwon, I; Zheng, S | 1 |
| Badr, M; Kopp, C; Meyer, J; Theison, S; Trommer, WE | 1 |
| Furuta, T; Honda, S; Ichinose, H; Kondo, K; Mori-Kojima, M; Nakata, R; Sakurai, M; Sanechika, S; Shimaguchi, S; Soga, T; Sudo, Y; Sugimoto, M; Sumi-Ichinose, C; Xu, F; Yamashita, J | 1 |
| Abbat, S; Bharatam, PV; Sharma, VK | 1 |
| Maurya, R; Prabhu, NP; Sharath, AK; Vadloori, B | 1 |
2 review(s) available for methotrexate and dihydrofolate
| Article | Year |
|---|---|
Acquired versus intrinsic resistance to methotrexate: diversity of the drug-resistant phenotype in mammalian cells.
Topics: Animals; Cricetinae; Drug Resistance; Folic Acid; Humans; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1991 |
Low dose methotrexate in inflammatory bowel disease: current status and future directions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; Drug Administration Schedule; Folic Acid; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 2003 |
49 other study(ies) available for methotrexate and dihydrofolate
| Article | Year |
|---|---|
Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase.
Topics: Binding Sites; Escherichia coli; Kinetics; Mathematics; Methotrexate; Mutation; Protein Binding; Pteridines; Spectrometry, Fluorescence; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1988 |
Methotrexate resistance of mouse dihydrofolate reductase: effect of substitution of phenylalanine-31 by serine or tryptophan.
Topics: Animals; Crystallography, X-Ray; Folic Acid Antagonists; Kinetics; Methotrexate; Mice; Mutagenesis, Site-Directed; Phenylalanine; Serine; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tryptophan | 1996 |
Circular-dichroism studies of ligand binding to dihydrofolate reductase from Lactobacillus casei MTX/R.
Topics: Circular Dichroism; Folic Acid; Lacticaseibacillus casei; Ligands; Methotrexate; NADP; Protein Binding; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1979 |
Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics.
Topics: Binding, Competitive; Computers; Escherichia coli; Folic Acid; Kinetics; Mathematics; Methotrexate; Protein Binding; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tritium | 1979 |
Automatic search for maximum similarity between molecular electrostatic potential distributions.
Topics: Benzylamines; Electrochemistry; Folic Acid; Methotrexate; Pharmaceutical Preparations; Phenethylamines; Quantum Theory; Receptors, Cell Surface; Software; Thermodynamics | 1991 |
Interaction of methotrexate polyglutamates and dihydrofolate during leucovorin rescue in a human breast cancer cell line (MCF-7).
Topics: Binding, Competitive; Breast Neoplasms; Folic Acid; Humans; Leucovorin; Methotrexate; Peptides; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tumor Cells, Cultured | 1990 |
The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis.
Topics: Antibodies; Base Sequence; Binding, Competitive; Cloning, Molecular; Cyanogen Bromide; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Molecular Sequence Data; Mutation; NADP; Peptide Fragments; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Transformation, Bacterial | 1990 |
Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Methotrexate; Pteroylpolyglutamic Acids; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1990 |
Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells.
Topics: Adenosine Triphosphate; Breast Neoplasms; Chromatography, High Pressure Liquid; Cytoplasm; Folic Acid; Formates; Humans; Kinetics; Magnesium; Methotrexate; Tumor Cells, Cultured | 1990 |
Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.
Topics: Aminopterin; Animals; Cattle; Chickens; Folic Acid; Folic Acid Antagonists; Methotrexate; Peptides; Polyglutamic Acid; Potassium Chloride; Sheep; Structure-Activity Relationship | 1986 |
Rescue effect of exogenous reduced folates on methotrexate polyglutamylation and dihydrofolate reductase activity in L1210 cells.
Topics: Animals; Folic Acid; Formyltetrahydrofolates; Leukemia L1210; Methotrexate; Mice; Peptides; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tumor Cells, Cultured | 1988 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
Nobel lecture in physiology or medicine--1988. Selective inhibitors of dihydrofolate reductase.
Topics: Animals; Bacteria; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Methotrexate; Molecular Conformation; Molecular Structure; Nobel Prize; Protein Conformation; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Trimethoprim | 1989 |
A fluorescence study of substrate and inhibitor binding to bovine liver dihydrofolate reductase.
Topics: Animals; Binding, Competitive; Cattle; Folic Acid; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; NADP; Protein Binding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1989 |
Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase.
Topics: Binding Sites; Folic Acid; Humans; Kinetics; Leucine; Methotrexate; Mutation; NADP; Phenylalanine; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim; X-Ray Diffraction | 1989 |
Dihydrofolate-mediated reversal of methotrexate toxicity to hepatoma cells in vitro.
Topics: Animals; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Leucovorin; Liver Neoplasms, Experimental; Methotrexate; Rats | 1986 |
Comparative activity of rat liver dihydrofolate reductase with 7,8-dihydrofolate and other 7,8-dihydropteridines.
Topics: Animals; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Kinetics; Liver; Methotrexate; Osmolar Concentration; Pteridines; Rats; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Urea | 1985 |
Changes in liver histology during methotrexate therapy of psoriasis correlated to the concentration of methotrexate and folate in erythrocytes.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Humans; Liver Diseases; Male; Methotrexate; Middle Aged; Psoriasis; Time Factors | 1985 |
Circular dichroism studies in the near UV of ligand binding to chicken liver dihydrofolate reductase.
Topics: Animals; Chickens; Circular Dichroism; Folic Acid; Liver; Methotrexate; NADP; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1983 |
Folate analogues. 22. Synthesis and biological evaluation of two analogues of dihydrofolic acid possessing a 7,8-dihydro-8-oxapterin ring system.
Topics: Enterococcus faecalis; Folic Acid; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate | 1983 |
Sequential methotrexate and 5-fluorouracil: mechanisms of synergy.
Topics: Animals; Biotransformation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Humans; Methotrexate; Mice; Neoplasm Transplantation; Sarcoma, Experimental; Thymidylate Synthase; Time Factors | 1983 |
Uptake of oxidized folates by rat liver mitochondria.
Topics: Animals; Biological Transport; Folic Acid; Intracellular Membranes; Kinetics; Male; Methotrexate; Mitochondria, Liver; Oxidation-Reduction; Rats; Structure-Activity Relationship | 1981 |
A simplified radioenzymatic assay for dihydrofolate reductase using [3H]dihydrofolate.
Topics: Dithionite; Folic Acid; Fractional Precipitation; Humans; Kinetics; Methods; Methotrexate; NADP; Oxidation-Reduction; Sulfates; Tetrahydrofolate Dehydrogenase; Tritium; Zinc; Zinc Sulfate | 1980 |
Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; Drug Resistance; Folic Acid; Kinetics; Lung; Methotrexate; Molecular Weight; Nucleic Acid Hybridization; Polyribosomes; Protein Biosynthesis; RNA, Ribosomal; Transcription, Genetic | 1980 |
Rational automatic search method for stable docking models of protein and ligand.
Topics: Algorithms; Computer Simulation; Folic Acid; Hydrogen Bonding; Ligands; Methotrexate; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Binding; Ribonuclease T1; Tetrahydrofolate Dehydrogenase; Thermodynamics; Triazines; Trimethoprim | 1994 |
Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.
Topics: Ammonium Sulfate; Catalysis; Chemical Precipitation; Enzyme Stability; Folic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; NADP; Phenylalanine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1994 |
Mutations of human dihydrofolate reductase causing decreased inhibition by methotrexate.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cricetinae; Escherichia coli; Folic Acid; Folic Acid Antagonists; Genetic Variation; Humans; Kinetics; Methotrexate; Mice; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Tetrahydrofolate Dehydrogenase | 1993 |
Methotrexate-insensitive mutants of human dihydrofolate reductase (hDHFR) constructed by site-directed mutagenesis at phenylalanine 34.
Topics: Amino Acid Sequence; Cloning, Molecular; Drug Resistance; Escherichia coli; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Tetrahydrofolate Dehydrogenase | 1993 |
Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro.
Topics: Base Sequence; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation; Humans; Methotrexate; Molecular Sequence Data; NADP; Protein Biosynthesis; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1993 |
In search of dihydrofolate reductase.
Topics: Folic Acid; History, 20th Century; Leucovorin; Methotrexate; NADP; Tetrahydrofolate Dehydrogenase | 1996 |
Time-efficient flexible superposition of medium-sized molecules.
Topics: Algorithms; Binding Sites; Computer Simulation; Folic Acid; Humans; Ligands; Methotrexate; Models, Chemical; Models, Molecular; Protein Conformation; Proteins; Tetrahydrofolate Dehydrogenase | 1997 |
Characterization of the bile acid sensitive methotrexate carrier of rat liver cells.
Topics: Animals; Bile Acids and Salts; Buffers; Carrier Proteins; Cell Line; Cell Membrane; Cells, Cultured; Folate Receptors, GPI-Anchored; Folic Acid; Kinetics; Liver; Male; Methotrexate; Oligomycins; Rats; Rats, Wistar; Receptors, Cell Surface; Sodium Chloride; Sulfobromophthalein; Tetrahydrofolates; Tritium; Xenobiotics | 1999 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured | 2000 |
Flexible alignment of small molecules.
Topics: Databases, Factual; Dipeptides; Estradiol; Folic Acid; Ligands; Methotrexate; Models, Molecular; Molecular Conformation; Proteins; Raloxifene Hydrochloride; Succinates; Tamoxifen | 2001 |
FLASHFLOOD: a 3D field-based similarity search and alignment method for flexible molecules.
Topics: Algorithms; Computer Simulation; Crystallography, X-Ray; Databases, Factual; Drug Design; Folic Acid; Methotrexate; Models, Chemical; Models, Molecular; Molecular Conformation; Software | 2001 |
Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.
Topics: Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Induction; Folic Acid; Folic Acid Antagonists; Ganciclovir; Gene Expression Regulation; Herpesvirus 1, Human; Humans; Methotrexate; Mice; Neoplasm Transplantation; Rats; Recombinant Fusion Proteins; Retroviridae; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Tomography, Emission-Computed; Transduction, Genetic; Transplantation, Heterologous; Trimetrexate; Tumor Cells, Cultured | 2002 |
A mathematical model of the folate cycle: new insights into folate homeostasis.
Topics: Allosteric Site; Animals; Dose-Response Relationship, Drug; Folic Acid; Homeostasis; Humans; Kinetics; Liver; Methionine; Methotrexate; Models, Biological; Models, Chemical; Models, Theoretical; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Up-Regulation; Vitamin B 12 Deficiency | 2004 |
Ligand binding modulates the mechanical stability of dihydrofolate reductase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biophysical Phenomena; Biophysics; CHO Cells; Chromatography, Affinity; Cricetinae; Folic Acid; Folic Acid Antagonists; Humans; Ligands; Methotrexate; Microscopy, Atomic Force; NAD; NADP; Niacinamide; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Transport; Spectrophotometry; Stress, Mechanical; Tensile Strength; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2005 |
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Folic Acid; Isoenzymes; Macromolecular Substances; Methotrexate; Models, Molecular; Molecular Sequence Data; Molecular Structure; NADP; Oxidoreductases; Protein Structure, Quaternary; Protozoan Proteins; Sequence Alignment; Trypanosoma cruzi | 2005 |
Folate synthesis in plants: purification, kinetic properties, and inhibition of aminodeoxychorismate synthase.
Topics: 4-Aminobenzoic Acid; Arabidopsis Proteins; Carbon-Nitrogen Ligases; Chorismic Acid; Escherichia coli; Folic Acid; Glutamine; Kinetics; Methotrexate; Pyruvic Acid; Recombinant Fusion Proteins; Substrate Specificity; Transaminases | 2006 |
Fingerprinting DHFR in single-molecule AFM studies.
Topics: Animals; Biophysical Phenomena; Biophysics; CHO Cells; Chromatography, Affinity; Cricetinae; Cricetulus; Folic Acid; Folic Acid Antagonists; Humans; Ligands; Methotrexate; Microscopy, Atomic Force; NAD; NADP; Niacinamide; Peptide Mapping; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Transport; Spectrophotometry; Stress, Mechanical; Tensile Strength; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2006 |
Pattern recognition based on color-coded quantum mechanical surfaces for molecular alignment.
Topics: Algorithms; Benzodiazepines; Color; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; HIV Reverse Transcriptase; Methotrexate; Models, Molecular; Nevirapine; Pattern Recognition, Automated; Quantum Theory; Tetrahydrofolate Dehydrogenase | 2008 |
The use of local surface properties for molecular superimposition.
Topics: Amino Acid Chloromethyl Ketones; Anti-HIV Agents; Anticoagulants; Antimetabolites, Antineoplastic; Crystallography, X-Ray; Dipeptides; Folic Acid; HIV Protease Inhibitors; Humans; Imidazoles; Ligands; Methotrexate; Models, Molecular; Molecular Structure; Piperidines; Protein Binding; Proteins; Quinoxalines; Reverse Transcriptase Inhibitors; Software; Static Electricity; Structure-Activity Relationship; Sulfur Compounds; Surface Properties; Tetrahydrofolate Dehydrogenase | 2008 |
Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.
Topics: Adenosine Triphosphate; Enzyme Inhibitors; Folic Acid; Glutamic Acid; Kinetics; Methotrexate; Peptide Synthases; Plasmodium falciparum; Protozoan Proteins; Pterins; Substrate Specificity; Tetrahydrofolates | 2010 |
Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Computer Simulation; Escherichia coli; Folic Acid; Folic Acid Antagonists; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Naphthalenes; Phenylalanine; Protein Binding; Protein Engineering; Recombinant Proteins; Sequence Alignment; Tetrahydrofolate Dehydrogenase; Tryptophan | 2013 |
Methotrexate-gelonin conjugate - an inhibitor of MCF-7 cells expressing the dihydrofolate receptor.
Topics: Amino Acid Sequence; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Immunotoxins; MCF-7 Cells; Methotrexate; Molecular Sequence Data; Protein Biosynthesis; Ribosome Inactivating Proteins, Type 1; Tetrahydrofolate Dehydrogenase | 2014 |
Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.
Topics: Animals; Biopterins; Folic Acid; Kinetics; Metabolomics; Methotrexate; Mice; Mice, Transgenic; Oxidoreductases; Tetrahydrofolate Dehydrogenase | 2014 |
Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes.
Topics: Enzyme Activation; Folic Acid; Folic Acid Antagonists; Methotrexate; Molecular Docking Simulation; Protozoan Proteins; Tetrahydrofolate Dehydrogenase | 2017 |
Homology modelling, molecular docking, and molecular dynamics simulations reveal the inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase enzyme by Withaferin-A.
Topics: Enzyme Inhibitors; Folic Acid; Humans; Leishmania donovani; Methotrexate; Molecular Docking Simulation; Molecular Dynamics Simulation; Multienzyme Complexes; Plant Extracts; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Withania; Withanolides | 2018 |