Compounds > methoctramine

methoctramine and gamma-aminobutyric acid

methoctramine has been researched along with gamma-aminobutyric acid in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (50.00)18.2507
2000's4 (33.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K1
Jiang, ZG; North, RA; Sugita, S; Uchimura, N1
Bogaert, L; Ebinger, G; Michotte, Y; Smolders, I1
Clero, E; Costentin, J; Dourmap, N1
Baba, H; Goldstein, PA; Kohno, T; Okamoto, M; Shimoji, K; Yoshimura, M1
Harsing, LG; Zigmond, MJ1
Ebinger, G; Izurieta-Sánchez, P; Michotte, Y; Sarre, S1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S1

Reviews

1 review(s) available for methoctramine and gamma-aminobutyric acid

ArticleYear
The role of receptor binding in drug discovery.
    Journal of natural products, 1993, Volume: 56, Issue:4

    Topics: Animals; Drug Design; Humans; Receptors, Drug

1993

Other Studies

11 other study(ies) available for methoctramine and gamma-aminobutyric acid

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
    Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21

    Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship

2010
Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.
    Proceedings of the National Academy of Sciences of the United States of America, 1991, Mar-15, Volume: 88, Issue:6

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain; Corpus Striatum; Diamines; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Kinetics; Muscarine; Neurons; Nucleus Accumbens; Organ Specificity; Parasympatholytics; Pirenzepine; Quinoxalines; Rats; Receptors, Muscarinic; Synapses

1991
Muscarinic modulation of striatal dopamine, glutamate, and GABA release, as measured with in vivo microdialysis.
    Journal of neurochemistry, 1997, Volume: 68, Issue:5

    Topics: Animals; Cholinergic Agents; Corpus Striatum; Diamines; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Parasympatholytics; Parasympathomimetics; Pilocarpine; Pirenzepine; Rats; Rats, Wistar; Substantia Nigra

1997
Involvement of cholinergic neurons in the release of dopamine elicited by stimulation of mu-opioid receptors in striatum.
    Brain research, 1997, Feb-28, Volume: 749, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Aziridines; Choline; Corpus Striatum; Diamines; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; gamma-Aminobutyric Acid; Homovanillic Acid; Infusions, Parenteral; Interneurons; Kinetics; Male; Microdialysis; Neurotoxins; Parasympatholytics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Synaptosomes

1997
Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn.
    The Journal of physiology, 1998, Apr-01, Volume: 508 ( Pt 1)

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Carbachol; Diamines; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Muscarinic Agonists; Neostigmine; Neurons; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Substantia Gelatinosa; Synaptic Transmission; Tetrodotoxin

1998
Postsynaptic integration of cholinergic and dopaminergic signals on medium-sized GABAergic projection neurons in the neostriatum.
    Brain research bulletin, 1998, Volume: 45, Issue:6

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Diamines; Electric Stimulation; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Models, Neurological; Muscarinic Agonists; Muscarinic Antagonists; Neostriatum; Neurons; Oxotremorine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Dopamine; Receptors, Muscarinic; Signal Transduction; Sulpiride; Tetrodotoxin

1998
Muscarinic antagonists in substantia nigra influence the decarboxylation of L-dopa in striatum.
    European journal of pharmacology, 2000, Jul-07, Volume: 399, Issue:2-3

    Topics: Analysis of Variance; Animals; Corpus Striatum; Decarboxylation; Diamines; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Levodopa; Male; Microdialysis; Muscarinic Antagonists; Neurotransmitter Agents; Parasympatholytics; Perfusion; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Substantia Nigra; Time Factors; Trihexyphenidyl

2000
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

2008
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013