methiothepin has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (29.17) | 18.7374 |
| 1990's | 33 (45.83) | 18.2507 |
| 2000's | 14 (19.44) | 29.6817 |
| 2010's | 4 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bull, D; den Daas, I; Foord, S; Goodson, S; Kilpatrick, G; Lee, M; Rees, S | 1 |
| Adham, N; Bard, JA; Branchek, TA; Vaysse, P; Weinshank, RL; Zgombick, J | 1 |
| Adham, N; Bard, J; Branchek, TA; Durkin, M; Hartig, PR; Kao, HT; Olsen, M; Schecter, LE; Urquhart, D; Weinshank, RL | 1 |
| Hamblin, MW; Jose, PA; Metcalf, MA; Monsma, FJ; Shen, Y; Sibley, DR | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Amlaiky, N; Boschert, U; Grailhe, R; Hen, R; Mattei, MG; Matthes, H; Muscatelli, F; Plassat, JL | 1 |
| Gommeren, W; Haegeman, G; Heylen, L; Lesage, AS; Leysen, JE; Luyten, WH; Schotte, A; Van de Weyer, I; Van Gompel, P; Vanhoenacker, P; Wouters, R | 1 |
| Chang, DJ; Eglen, RM; Jasper, JR; Kosaka, A; To, ZP | 1 |
| Beleta, J; Doménech, T; Palacios, JM | 1 |
| Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L | 1 |
| Brown, AM; Collin, LL; Ellis, CE; Forbes, IT; Gittins, SA; Gloger, I; Hagan, J; Middlemiss, DN; Riley, G; Thomas, DR | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Grabtree, GW; Grailhe, R; Hen, R | 1 |
| Bach, T; Krobert, KA; Kvingedal, AM; Levy, FO; Syversveen, T | 1 |
| Glennon, RA | 1 |
| Bai, F; Johnstone, EM; Little, SP; Nelson, DL; Su, C; Varga, G; Yin, T | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Buck, LB; Petrascheck, M; Ye, X | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Lepailleur, A; Rochais, C; Thirumaran, SL | 1 |
| Newman-Tancredi, A; Strange, PG; Sundaram, H | 1 |
| Motevalian, M; Parsons, AA; Whalley, ET | 1 |
| Dreteler, GH; Ramage, AG; Saxena, PR; Wouters, W | 1 |
| Feniuk, W; Humphrey, PP; Perren, MJ | 1 |
| Barzizza, A; Maura, G; Raiteri, M | 1 |
| Dedeoğlu, A; Fisher, LA | 1 |
| Barzizza, A; Folghera, S; Maura, G; Raiteri, M | 1 |
| Carlsson, S; Hoffmann, P; Skarphedinsson, JO; Thorén, P | 1 |
| Marsden, CA; Martin, KF | 1 |
| Bom, AH; Saxena, PR; Verdouw, PD | 1 |
| Blier, P; Chaput, Y; de Montigny, C; Steinberg, S | 1 |
| Cherqui, C; Dabiré, H; Drouillat, M; Laubie, M; Schmitt, H | 1 |
| Jenner, P; Marsden, CD; Stewart, BR | 1 |
| Ahlenius, S; Fernandez-Guasti, A; Larsson, K | 1 |
| Bervoets, K; Colpaert, FC; Millan, MJ | 1 |
| Chaput, Y; de Montigny, C | 1 |
| Arvidsson, LE; Gradin, K; Hedner, T; Hjorth, S; Persson, B; Pettersson, A | 1 |
| Hibert, M; Middlemiss, DN | 1 |
| Bonanno, G; Maura, G; Raiteri, M | 1 |
| Feuerstein, TJ; Hertting, G; Lupp, A | 1 |
| Houston, DS; Vanhoutte, PM | 1 |
| Cervo, L; Samanin, R | 1 |
| Maura, G; Raiteri, M; Roccatagliata, E; Ulivi, M | 1 |
| Anderson, EG; Marszalec, W; Scroggs, RS | 1 |
| Eide, PK; Tjølsen, A | 1 |
| Lis, EV; Martin, GE | 1 |
| Svensson, L | 1 |
| Ahlenius, S; Larsson, K | 1 |
| Middlemiss, DN | 1 |
| Björklund, M; Jäkälä, P; Kaukua, J; Koivisto, E; Riekkinen, P; Sirviö, J | 1 |
| Miyamoto, A; Nishio, A; Sakota, T | 1 |
| Katusić, ZS; Krstić, MK | 1 |
| Kruk, ZL; O'Connor, JJ | 1 |
| Abdelghani, H; Fong, PP; Hardege, JD; Kyozuka, K; Ram, JL | 1 |
| Blier, P; de Montigny, C; Dennis, T | 1 |
| Blier, P; De Montigny, C; Lista, A | 1 |
| Bobirnac, I; Schoeffter, P | 1 |
| Cassel, JC; Jackisch, R; Jeltsch, H; Lauth, D; Neufang, B; Szabo, B | 1 |
| Clayton, RA; MacLean, MR; Morecroft, I; Templeton, AG | 1 |
| Alper, RH; Bowman, M; Braun, CJ; Szabó, A | 1 |
| Pearce, WJ; Purdy, R; Teng, GQ; Williams, J; Zhang, L | 1 |
| Bard, JA; Branchek, T; Edvinsson, L; Longmore, J; Nilsson, T; Pantev, E; Shaw, D | 1 |
| Dacquet, C; Dubreuil, V; Jacoby, E; Kellett, E; Lavielle, G; Millan, MJ; Milligan, G; Spedding, M | 1 |
| Honda, M; Ono, H | 1 |
| Gabriel, A; Lim, KJ; Meuser, T; Pierce Palmer, P; Pietruck, C; Xie, GX | 1 |
| Araujo-Alvarez, JM; Delgado, A; Oviedo-Chávez, A; Querejeta, E; Quiñones-Cárdenas, AR | 1 |
| Grandoso, L; Pineda, J; Torrecilla, M; Ugedo, L | 1 |
| Calama, E; Martín, ML; Morán, A; Ortíz de Urbina, AV; San Román, L | 1 |
| Centurión, D; Gupta, S; MaassenVanDenBrink, A; Mehotra, S; Sánchez-López, A; Villalón, CM | 1 |
| García, M; Martín, ML; Morán, A; Ortizde Urbina, AV; San Román, L | 1 |
| Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF | 1 |
2 review(s) available for methiothepin and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Structure-activity relationships of serotonin 5-HT
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship | 2019 |
70 other study(ies) available for methiothepin and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Cloning and characterisation of the human 5-HT5A serotonin receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; Genome, Human; GTP-Binding Proteins; Humans; Mice; Molecular Sequence Data; Radioligand Assay; Receptors, Serotonin; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serotonin; Tissue Distribution; Transfection | 1994 |
Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.
Topics: Adenylyl Cyclases; Base Sequence; Cloning, Molecular; DNA Primers; Humans; Molecular Sequence Data; Receptors, Serotonin; Sequence Alignment; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction | 1993 |
Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Cloning, Molecular; Colforsin; Dose-Response Relationship, Drug; Gene Library; Guinea Pigs; Humans; Indoles; Lymphocytes; Molecular Sequence Data; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Serotonin; Serotonin Receptor Agonists; Spiperone; Sulfonamides; Sumatriptan; Tissue Distribution | 1993 |
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Line; Cell Membrane; Cloning, Molecular; Cyclic AMP; Gene Expression; Kidney Tubules, Proximal; Lysergic Acid Diethylamide; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Radioligand Assay; Rats; Receptors, Serotonin; Recombinant Proteins; Serotonin; Transfection | 1993 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Chromosome Mapping; Cloning, Molecular; DNA; Gene Expression; Humans; In Situ Hybridization; Mice; Molecular Sequence Data; Receptors, Serotonin; Serotonin Receptor Agonists | 1993 |
Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamin
Topics: Animals; Benzopyrans; Cattle; Cloning, Molecular; Glioma; HeLa Cells; Humans; Mice; Migraine Disorders; Propylamines; Protein Binding; Pyrimidines; Radioligand Assay; Receptors, Serotonin; Serotonin Receptor Agonists; Signal Transduction; Tritium; Tumor Cells, Cultured; Vasoconstrictor Agents | 1996 |
Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Humans; Molecular Sequence Data; Placenta; Radioligand Assay; Rats; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 1997 |
Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist.
Topics: Benzamides; Binding, Competitive; Gene Expression; HeLa Cells; Humans; Kinetics; Ligands; Pyridines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Substantia Nigra; Tritium | 1997 |
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanine Nucleotides; Hippocampus; Humans; Male; Membranes; Piperazines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.
Topics: Adenylyl Cyclases; Cell Line; Cloning, Molecular; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Piperidines; Protein Binding; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Sulfonamides | 1998 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Cell Line; COS Cells; DNA; Evolution, Molecular; Gene Expression; Genes; Humans; Membranes; Mice; Molecular Sequence Data; Phylogeny; Radioligand Assay; Receptors, Serotonin; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2001 |
The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution.
Topics: Adenylyl Cyclases; Alternative Splicing; Binding, Competitive; Brain; Cell Line; Cloning, Organism; Genetic Variation; Humans; Radioligand Assay; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tissue Distribution | 2001 |
Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Chickens; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Gerbillinae; Guinea Pigs; Haplorhini; Humans; Molecular Sequence Data; Protein Binding; Rabbits; Receptors, Serotonin; Serotonin Agents; Swine | 2004 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevity; Methiothepin; Mianserin; Octopamine; Receptors, Biogenic Amine; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Starvation | 2007 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Pharmacological characterisation of the 5-HT1A serotonin receptor using the agonist [3H]8-OH-DPAT, and the antagonist [3H]spiperone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; CHO Cells; Cricetinae; Humans; Kinetics; Lisuride; Methiothepin; Pindolol; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Antagonists; Spiperone; Transfection; Tritium | 1992 |
Contractile effects of 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan in human isolated basilar artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Antihypertensive Agents; Basilar Artery; Humans; In Vitro Techniques; Indoles; Methiothepin; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Piperazines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Sulfonamides; Sumatriptan; Tetrahydronaphthalenes; Vasoconstrictor Agents | 1991 |
Pressor effects following microinjection of 5-HT1A receptor agonists into the raphe obscurus of the anaesthetized rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Electric Stimulation; Glutamates; Glutamic Acid; Heart Rate; Male; Methiothepin; Microinjections; Phrenic Nerve; Pindolol; Piperazines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1991 |
Vascular 5-HT1-like receptors that mediate contraction of the dog isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized dogs are not of the 5-HT1A or 5-HT1D subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Atropine; Carotid Arteries; Dogs; Ganglionic Blockers; In Vitro Techniques; Indoles; Ketanserin; Methiothepin; Muscle, Smooth, Vascular; Pyrilamine; Receptors, Serotonin; Saphenous Vein; Spiperone; Sulfonamides; Sumatriptan; Tetrahydronaphthalenes; Vasoconstriction; Vasoconstrictor Agents | 1991 |
Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Calcium; Cerebellum; Citalopram; Cyclic GMP; Fenfluramine; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Methiothepin; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1991 |
Central nervous actions of serotonin and a serotonin1A receptor agonist: cardiovascular excitation at low doses.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Brain; Dose-Response Relationship, Drug; Heart Rate; Male; Methiothepin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1991 |
Release of endogenous aspartate from rat cerebellum slices and synaptosomes: inhibition mediated by a 5-HT2 receptor and by a 5-HT1 receptor of a possibly novel subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Aspartic Acid; Calcium; Cerebellum; Ketanserin; Male; Methiothepin; Potassium; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synaptosomes; Tetrahydronaphthalenes | 1991 |
Role of different serotonergic receptors in the long-lasting blood pressure depression following muscle stimulation in the spontaneously hypertensive rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Electric Stimulation; Heart Rate; Indoles; Male; Methiothepin; Muscles; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Tetrahydronaphthalenes; Time Factors; Tropisetron | 1990 |
Involvement of 5-HT1A- and alpha 2-receptors in the decreased 5-hydroxytryptamine release and metabolism in rat suprachiasmatic nucleus after intravenous 8-hydroxy-2-(n-dipropylamino) tetralin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Dioxanes; Hydroxyindoleacetic Acid; Idazoxan; Male; Methiothepin; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Suprachiasmatic Nucleus; Tetrahydronaphthalenes | 1986 |
Carotid haemodynamics in pigs during infusions of 8-OH-DPAT: reduction in arteriovenous shunting is mediated by 5-HT1-like receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Arteriovenous Anastomosis; Blood Pressure; Carotid Arteries; Heart Rate; Hemodynamics; Infusions, Intra-Arterial; Ketanserin; Methiothepin; Microspheres; Naphthalenes; Receptors, Serotonin; Swine; Tetrahydronaphthalenes | 1989 |
Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the rat dorsal raphe nucleus.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electrophysiology; Lysergic Acid Diethylamide; Male; Methiothepin; Neurons; Propranolol; Quinazolines; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin Antagonists; Spiperone; Tetrahydronaphthalenes | 1989 |
Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (+/-)8-OH-DPAT in anaesthetized dogs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; alpha-Methyltyrosine; Anesthesia; Animals; Blood Pressure; Catecholamines; Cisterna Magna; Dogs; Female; Heart Rate; Male; Medulla Oblongata; Methiothepin; Methyltyrosines; Microinjections; Naphthalenes; Neurons; Pindolol; Pressoreceptors; Sympathetic Nervous System; Tetrahydronaphthalenes | 1989 |
Induction of purposeless chewing behaviour in rats by 5-HT agonist drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Male; Methiothepin; Methoxydimethyltryptamines; Mianserin; Parasympatholytics; Piperazines; Propranolol; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone; Tetrahydronaphthalenes | 1989 |
Evidence for the involvement of central 5-HT1A receptors in the mediation of lordosis behavior in the female rat.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Betaxolol; Estradiol; Female; Male; Methiothepin; Pindolol; Piperidines; Posture; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sexual Behavior, Animal; Tetrahydronaphthalenes | 1989 |
Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Hyperesthesia; Lisuride; Male; Methiothepin; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1989 |
Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electric Stimulation; Electrophysiology; Indoles; Male; Methiothepin; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Synaptic Transmission; Tetrahydronaphthalenes | 1988 |
Cardiovascular effects in the Sprague-Dawley rat of 8-hydroxy-2(di-N-propylamino) tetralin, a selective 5-hydroxytryptamine receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Blood Pressure; Heart Rate; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Male; Methiothepin; Naphthalenes; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes; Time Factors | 1985 |
Stereoselective blockade at the 5-HT autoreceptor and inhibition of radioligand binding to central 5-HT recognition sites by the optical isomers of methiothepin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dibenzothiepins; Frontal Lobe; In Vitro Techniques; Ketanserin; Male; Methiothepin; Piperidines; Rats; Receptors, Serotonin; Serotonin; Stereoisomerism; Tetrahydronaphthalenes | 1986 |
Pharmacological characterization of release-regulating serotonin autoreceptors in rat cerebellum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebellum; In Vitro Techniques; Indoles; Male; Methiothepin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Synaptosomes; Tetrahydronaphthalenes | 1986 |
The serotonin (5-HT) autoreceptor in the hippocampus of the rabbit: role of 5-HT biophase concentration.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Mathematics; Metergoline; Methiothepin; Methoxydimethyltryptamines; Methysergide; Phentolamine; Pindolol; Quipazine; Rabbits; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes | 1987 |
Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Ketanserin; Male; Metergoline; Methiothepin; Muscle, Smooth, Vascular; Pindolol; Receptors, Serotonin; Tetrahydronaphthalenes; Vasodilation | 1988 |
Potential antidepressant properties of 8-hydroxy-2-(di-n-propylamino)tetralin, a selective serotonin1A receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Interactions; Haloperidol; Male; Methiothepin; Naphthalenes; Physical Exertion; Rats; Receptors, Serotonin; Serotonin; Sulpiride; Swimming; Tetrahydronaphthalenes | 1987 |
Serotonin-glutamate interaction in rat cerebellum: involvement of 5-HT1 and 5-HT2 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Calcium; Cerebellum; Glutamates; In Vitro Techniques; Ketanserin; Male; Methiothepin; Potassium; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1988 |
Serotonin-induced reduction of the calcium-dependent plateau in frog dorsal root ganglion cells is blocked by serotonergic agents acting at 5-hydroxytryptamine1A sites.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Calcium; Dioxanes; Ganglia, Spinal; Methiothepin; Rana catesbeiana; Receptors, Serotonin; Serotonin; Spiperone; Spiro Compounds; Tetrahydronaphthalenes | 1988 |
Effects of serotonin receptor antagonists and agonists on the tail-flick response in mice involve altered tail-skin temperature.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Hypothermia, Induced; Male; Metergoline; Methiothepin; Methoxydimethyltryptamines; Mice; Mice, Inbred Strains; Reaction Time; Receptors, Serotonin; Skin Temperature; Tetrahydronaphthalenes | 1988 |
Hypotensive action of 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) in spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Cyproheptadine; Heart Rate; Injections, Intraperitoneal; Injections, Intraventricular; Male; Metergoline; Methiothepin; Naphthalenes; Rats; Rats, Inbred SHR; Tetrahydronaphthalenes | 1985 |
Effects of 8-OH-DPAT, lisuride and some ergot-related compounds on the acoustic startle response in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bromocriptine; Ergolines; Lisuride; Male; Metergoline; Methiothepin; Naphthalenes; Pergolide; Quinpirole; Rats; Rats, Inbred Strains; Reflex, Startle; Tetrahydronaphthalenes | 1985 |
Failure to antagonize the 8-hydroxy-2-di-n-propylamino)tetralin-induced facilitation of male rat sexual behavior by the administration of 5-HT receptor antagonists.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Male; Metergoline; Methiothepin; Naphthalenes; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Sexual Behavior, Animal; Tetrahydronaphthalenes | 1984 |
8-Hydroxy-2-(di-n-propylamino) tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H] 5-HT recognition site.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding Sites; Brain; In Vitro Techniques; Male; Methiothepin; Naphthalenes; Potassium; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes; Tritium | 1984 |
Modulation of rat neocortical high-voltage spindle activity by 5-HT1/5-HT2 receptor subtype specific drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Cerebral Cortex; Electroencephalography; Infusions, Parenteral; Ketanserin; Male; Methiothepin; Methysergide; Neural Pathways; Rats; Rats, Wistar; Receptors, Serotonin; Ritanserin; Thalamus | 1995 |
Characterization of 5-hydroxytryptamine receptors on the isolated pig basilar artery by functional and radioligand binding studies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basilar Artery; Binding, Competitive; Dose-Response Relationship, Drug; In Vitro Techniques; Ketanserin; Methiothepin; Muscle Contraction; Muscle, Smooth, Vascular; Radioligand Assay; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Swine | 1994 |
Further evidence that the tachycardiac response to 5-hydroxytryptamine in rats is not mediated via typical 5-HT2 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Pressure; Ergolines; Female; Heart Rate; Ketanserin; Male; Methiothepin; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin | 1994 |
Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Electric Stimulation; Electrophysiology; Fluoxetine; In Vitro Techniques; Indoles; Male; Methiothepin; Presynaptic Terminals; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Serotonin Receptor Agonists; Suprachiasmatic Nucleus | 1994 |
In vivo and in vitro induction of germinal vesicle breakdown in a freshwater bivalve, the zebra mussel Dreissena polymorpha (Pallas).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bivalvia; Female; Fertilization; Fresh Water; In Vitro Techniques; Kinetics; Male; Methiothepin; Oocytes; Serotonin; Spermatozoa; Time Factors | 1994 |
Delayed effects of spiperone on serotonin1A receptors in the dorsal hippocampus of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Culture Techniques; GTP-Binding Proteins; Hippocampus; Male; Methiothepin; Raphe Nuclei; Rats; Receptors, Serotonin; Spiperone; Synapses | 1993 |
Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Antagonism; gamma-Aminobutyric Acid; Hippocampus; Male; Methiothepin; Neurons; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Synapses | 1993 |
5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alprostadil; Animals; Cells, Cultured; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Epithelium; Ketanserin; Kidney Cortex; Methiothepin; Oxadiazoles; Pertussis Toxin; Piperazines; Propranolol; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Sumatriptan; Virulence Factors, Bordetella; Yohimbine | 1995 |
Downregulation of muscarinic- and 5-HT1B-mediated modulation of [3H]acetylcholine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts of septal origin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Atropine; Brain Tissue Transplantation; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Cholinesterase Inhibitors; Diffusion Chambers, Culture; Down-Regulation; Electric Stimulation; Female; Hippocampus; Hydroxyindoleacetic Acid; Mecamylamine; Methiothepin; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Nicotinic Antagonists; Norepinephrine; Oxotremorine; Physostigmine; Pyridines; Pyrroles; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Receptors, Serotonin; Septal Nuclei; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium | 1995 |
Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Benzamides; Humans; In Vitro Techniques; Ketanserin; Kinetics; Methiothepin; Pulmonary Artery; Pyridines; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstriction | 1996 |
Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Hemodynamics; Male; Methiothepin; Microinjections; Parasympatholytics; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 1996 |
Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Carotid Artery, Common; Cerebral Arteries; Female; Ketanserin; Male; Methiothepin; Muscle Contraction; Muscle, Smooth, Vascular; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sheep | 1998 |
Characterisation of 5-HT receptors in human coronary arteries by molecular and pharmacological techniques.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Cardiovascular System; Coronary Vessels; Dose-Response Relationship, Drug; Gene Expression; Humans; Immunohistochemistry; In Vitro Techniques; Ketanserin; Methiothepin; Oxazoles; Oxazolidinones; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; Tissue Distribution; Tryptamines; Vasoconstriction | 1999 |
S 14506: novel receptor coupling at 5-HT(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Dopamine Antagonists; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanylyl Imidodiphosphate; Hippocampus; Humans; Macromolecular Substances; Methiothepin; Models, Molecular; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Fusion Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Sodium; Transfection | 2001 |
No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Ergolines; Indoles; Male; Methiothepin; Oxadiazoles; Phenols; Piperazines; Pyridines; Rats; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Reflex, Monosynaptic; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Time Factors | 2001 |
5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Injections, Intra-Articular; Knee Joint; Lumbosacral Region; Male; Methiothepin; Microscopy, Fluorescence; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Anesthesia; Animals; Behavior, Animal; Denervation; Fluoxetine; Globus Pallidus; Male; Methiothepin; Neurons; Oxadiazoles; Piperazines; Pyridines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Tryptamines | 2005 |
alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Citalopram; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Idazoxan; In Vitro Techniques; Locus Coeruleus; Male; Methiothepin; Naloxone; Narcotic Antagonists; Neurons; Norepinephrine; Oxazines; Piperazines; Piperidines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 2005 |
Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biguanides; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Hindlimb; In Vitro Techniques; Infusions, Intravenous; Male; Methiothepin; Oxadiazoles; Perfusion; Piperazines; Pressure; Quinoxalines; Rats; Rats, Wistar; Ritanserin; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT3 Receptor Agonists; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Tryptamines; Vasoconstriction | 2005 |
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Buspirone; Clozapine; Decerebrate State; Dose-Response Relationship, Drug; Drug Interactions; Ergotamine; Heart Rate; Ketanserin; Lisuride; Male; Metergoline; Methiothepin; Methysergide; Phenylephrine; Piperazines; Pizotyline; Prazosin; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Yohimbine | 2006 |
Diabetes-induced changes in 5-hydroxytryptamine modulation of vagally-induced bradycardia in rat heart.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Biphenyl Compounds; Blood Glucose; Bradycardia; Cholinergic Agents; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Electric Stimulation; Ergolines; Heart; Heart Rate; Injections, Intravenous; Male; Methiothepin; Oxadiazoles; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tryptamines; Vagus Nerve | 2007 |
Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkaloids; Aminopyridines; Animals; Antidepressive Agents; Benzodioxoles; Data Interpretation, Statistical; Male; Methiothepin; Mice; Mice, Inbred ICR; Motor Activity; Piperazines; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyridines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Swimming | 2011 |