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methionine sulfoximine and melphalan

methionine sulfoximine has been researched along with melphalan in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (45.65)	18.7374
1990's	24 (52.17)	18.2507
2000's	1 (2.17)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alvero-Jackson, H; Benathan, M; Frenk, E; Mooy, AM; Scaletta, C	1
Guenthner, TM; Jevtović-Todorović, V	1
Alaoui-Jamali, MA; Batist, G; Centurioni, GM; Lehnert, S; Panasci, L; Schecter, R	1
FitzGerald, GB; Prezioso, JA; Wick, MM	1
Carp, N; Comis, RL; Hamilton, TC; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Padavic, K; Tew, KD; Young, RC	1
Greig, NH; Rapoport, SI; Smith, QR; Takada, Y; Vistica, DT	1
Awasthi, YC; Gupta, V; Medh, RD	1
Bellamy, WT; Dalton, WS; Gleason, MC; Grogan, TM; Trent, JM	1
Britten, RA; Broughton, C; Browning, PG; Green, JA; Warenius, HM; White, R	1
Frankfurt, OS; Seckinger, D; Sugarbaker, EV	2
Benz, CC; Ford, JM; Hait, WN; Matlin, SA	1
Bigner, DD; Friedman, HS; Griffith, OW; McMahon, DP; Postels, DG; Skapek, SX; VanDellen, AF	1
Hamilton, TC; O'Dwyer, PJ; Ozols, RF; Young, RC	1
Gipp, JJ; McClelland, RA; Mulcahy, RT; Ublacker, GA	1
Barranco, SC; Beasley, EG; Liu, NH; MacLean, KK; Schellenberg, K; Shaeffer, J; Townsend, CM; Weintraub, B	1
Du, DL; Grieshaber, CK; Murphy, MJ; Volpe, DA	1
DeGraff, W; Friedman, N; Mitchell, JB; Russo, A	1
Bigner, DD; Bigner, SH; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Horton, JK; Lilley, E; Rosenberg, MC	1
Ardiet, C; Navarro, C; Sapet, C; Tranchand, B	1
Grieshaber, CK; Liao, JT; Page, JG; Smith, AC; Wientjes, MG	1
Bigner, DD; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Hilton, J; Lippitz, B; Schold, SC	1
Frankfurt, OS	1
Deeg, HJ; Luk, K; Shulman, HM; Shuman, WB; Storb, R	1
Roizin-Towle, L	1
Hamilton, TC; Ozols, RF; Young, RC	1
Edgren, M; Ehrsson, H; Hansson, J; Nilsson, B; Ringborg, U	1
Bigner, DD; Colvin, OM; Elion, GB; Friedman, HS; Griffith, OW; Skapek, SX	1
Dorr, RT	1
Dorr, RT; Liddil, JD; Soble, MJ	1
Cohen, GM; d'Arcy Doherty, M; Jordan, J	1
Carmichael, J; DeGraff, W; Fisher, J; Friedman, N; Mitchell, JB; Phillips, T; Russo, A; Tochner, Z	1
Behrens, BC; Dykes, D; Fine, RL; Hamilton, TC; Louie, KG; Ozols, RF; Plowman, J	1
Ahmad, S; Greene, K; Kramer, RA; Vistica, DT	1
Batist, G; Behrens, BC; Grotzinger, KR; Hamilton, TC; Louie, KG; McKoy, WM; Ozols, RF; Tsuruo, T; Winker, MA; Young, RC	1
Biaglow, JE; Costello, T; Hall, EJ; Roizin-Towle, L; Varnes, ME	1
Green, JA; Hamilton, TC; Ozols, RF; Rogan, AM; Vistica, DT; Young, RC	1
Somfai-Relle, S; Suzukake, K; Vistica, BP; Vistica, DT	1
Brennan, J; Gallo, JM; Halbherr, T; Hamilton, TC; Laub, PB; O'Dwyer, PJ; Ozols, RF	1
Aloui-Jamali, MA; Batist, G; Lehnert, S; Vestergaard, J	1
Beyers, KL; Siemann, DW	1
Alberti, D; Arzoomanian, RZ; Bailey, HH; Mulcahy, RT; Pomplun, M; Spriggs, DR; Tombes, MB; Tutsch, KD; Wilding, G	1
Canada, A; Herman, L; Kidd, K; Robertson, C; Trump, D	1
Mulcahy, RT; Ripple, M; Wilding, G	1
Bookman, MA; Brennan, J; Comis, RL; Gallo, JM; Halbherr, T; Hamilton, TC; Hoffman, J; Kilpatrick, D; LaCreta, FP; O'Dwyer, PJ; Ozols, RF; Young, RC	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1

Reviews

1 review(s) available for methionine sulfoximine and melphalan

Article	Year
The role of glutathione in drug resistance. Cancer treatment reviews, 1990, Volume: 17 Suppl A Topics: Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; DNA Repair; Drug Resistance; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms	1990

Trials

3 trial(s) available for methionine sulfoximine and melphalan

Article	Year
Time-dependent pharmacodynamic models in cancer chemotherapy: population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a Phase I trial of melphalan and BSO. Cancer research, 1995, Oct-15, Volume: 55, Issue:20 Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Enzyme Inhibitors; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Neoplasms; Neutrophils	1995
Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Infusions, Intravenous; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms	1994
Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Buthionine Sulfoximine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Linear Models; Male; Melphalan; Methionine Sulfoximine; Middle Aged; Nausea; Neoplasm Recurrence, Local; Neoplasms; Neutropenia; Neutrophils; Radiography; Vomiting	1996

Other Studies

42 other study(ies) available for methionine sulfoximine and melphalan

Article	Year
Relationship between melanogenesis, glutathione levels and melphalan toxicity in human melanoma cells. Melanoma research, 1992, Volume: 2, Issue:5-6 Topics: Bucladesine; Buthionine Sulfoximine; Cell Differentiation; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Eye Neoplasms; Glutathione; Glutathione Transferase; Humans; Kinetics; Melanins; Melanoma; Melphalan; Methionine Sulfoximine; Microscopy, Electron; Monophenol Monooxygenase; Neoplasm Staging; Skin Neoplasms; Tumor Cells, Cultured	1992
Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine. Correlation with enhanced alkylating agent cytotoxicity to human melanoma cells in vitro. Biochemical pharmacology, 1992, Oct-06, Volume: 44, Issue:7 Topics: Buthionine Sulfoximine; Carmustine; Cell Division; Cell Nucleus; Cytosol; Doxorubicin; Drug Synergism; Glutathione; Glutathione Disulfide; Humans; Melanoma; Melphalan; Methionine Sulfoximine; Oxidation-Reduction; Tumor Cells, Cultured	1992
Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:5 Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Survival; Chlorambucil; DNA; Drug Interactions; Drug Resistance; Glutathione; Glutathione Transferase; Mammary Neoplasms, Experimental; Mechlorethamine; Melphalan; Methionine Sulfoximine; Rats; RNA, Messenger; Tumor Cells, Cultured	1992
Melanoma cytotoxicity of buthionine sulfoximine (BSO) alone and in combination with 3,4-dihydroxybenzylamine and melphalan. The Journal of investigative dermatology, 1992, Volume: 99, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Dopamine; Glutathione Peroxidase; Humans; Hydrogen Peroxide; Melanoma; Melanoma, Experimental; Melphalan; Methionine Sulfoximine; Mice; Tumor Cells, Cultured	1992
Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results. Journal of the National Cancer Institute, 1992, Feb-19, Volume: 84, Issue:4 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Middle Aged; Neoplasms	1992
Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier. Cancer chemotherapy and pharmacology, 1991, Volume: 29, Issue:2 Topics: 2-Naphthylamine; Amino Acid Transport Systems; Animals; Azaserine; Blood-Brain Barrier; Brain; Buthionine Sulfoximine; Carrier Proteins; Diazooxonorleucine; Isoxazoles; Male; Melphalan; Methionine Sulfoximine; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains	1991
Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism. Biochemical pharmacology, 1991, Jul-05, Volume: 42, Issue:2 Topics: Buthionine Sulfoximine; Cell Survival; Drug Resistance; Glutathione; Glutathione Transferase; Humans; Melphalan; Methionine Sulfoximine; Multiple Myeloma; Neoplasm Transplantation; Tumor Cells, Cultured	1991
Development and characterization of a melphalan-resistant human multiple myeloma cell line. Cancer research, 1991, Feb-01, Volume: 51, Issue:3 Topics: Alkylating Agents; Buthionine Sulfoximine; Cell Survival; DNA, Neoplasm; Drug Resistance; Glutathione; Humans; Karyotyping; Melphalan; Methionine Sulfoximine; Multiple Myeloma; Myeloma Proteins; Tumor Cells, Cultured	1991
The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells. Biochemical pharmacology, 1991, Feb-15, Volume: 41, Issue:4 Topics: Buthionine Sulfoximine; Cell Nucleus; Drug Resistance; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured	1991
Intercellular transfer of drug resistance. Cancer research, 1991, Feb-15, Volume: 51, Issue:4 Topics: Antimetabolites; Buthionine Sulfoximine; Cell Communication; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; DNA; DNA Damage; Drug Resistance; Female; Flow Cytometry; Glutathione; Humans; In Vitro Techniques; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tetradecanoylphorbol Acetate	1991
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers. Cancer letters, 1991, Volume: 56, Issue:1 Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmustine; Cell Division; Cell Line; Chlorambucil; Cisplatin; Drug Antagonism; Drug Resistance; Glutathione Transferase; Gossypol; Humans; In Vitro Techniques; Isomerism; Melphalan; Methionine Sulfoximine; Rats	1991
Melphalan-induced toxicity in nude mice following pretreatment with buthionine sulfoximine. Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:1 Topics: Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Buthionine Sulfoximine; Drug Synergism; Glutathione; Intestines; Kidney; Liver; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Muscles; Time Factors; Weight Loss	1991
Enhancement of melphalan (L-PAM) toxicity by reductive metabolites of 1-methyl-2-nitroimidazole, a model nitroimidazole chemosensitizing agent. Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12 Topics: Buthionine Sulfoximine; Cell Survival; Drug Synergism; Glutathione; Humans; In Vitro Techniques; Melphalan; Methionine Sulfoximine; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship; Tumor Cells, Cultured	1990
Changes in glutathione content and resistance to anticancer agents in human stomach cancer cells induced by treatments with melphalan in vitro. Cancer research, 1990, Jun-15, Volume: 50, Issue:12 Topics: Buthionine Sulfoximine; Cell Cycle; Cell Survival; Drug Screening Assays, Antitumor; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Stomach Neoplasms; Time Factors; Tumor Cells, Cultured	1990
Effects of L-phenylalanine mustard and L-buthionine sulfoximine on murine and human hematopoietic progenitor cells in vitro. Cancer research, 1990, Jul-01, Volume: 50, Issue:13 Topics: Animals; Buthionine Sulfoximine; Colony-Forming Units Assay; Drug Synergism; Female; Hematopoietic Stem Cells; Humans; Melphalan; Methionine Sulfoximine; Mice; Time Factors	1990
Flow cytometric analysis of DNA damage and repair in the cells resistant to alkylating agents. Cancer research, 1990, Aug-01, Volume: 50, Issue:15 Topics: Alkylating Agents; Antibodies, Monoclonal; Buthionine Sulfoximine; Cell Line; Cell Survival; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Kinetics; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured	1990
Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs. Cancer research, 1986, Volume: 46, Issue:6 Topics: Antineoplastic Agents; Bleomycin; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Cisplatin; Glutathione; Humans; Lung; Lung Neoplasms; Melphalan; Methionine Sulfoximine; Neoplasms; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Zinostatin	1986
Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. Cancer research, 1989, Dec-15, Volume: 49, Issue:24 Pt 1 Topics: Animals; Buthionine Sulfoximine; Drug Interactions; Drug Resistance; Female; Glutathione; Glutathione Transferase; Humans; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rhabdomyosarcoma; Transplantation, Heterologous; Vincristine	1989
[Cellular pharmacokinetics of melphalan alone or in combination on human lymphoma or lymphoblasts]. Bulletin du cancer, 1989, Volume: 76, Issue:8 Topics: Antimetabolites; Blastomeres; Burkitt Lymphoma; Buthionine Sulfoximine; Cell Line; Etoposide; Humans; Lymphocytes; Melphalan; Methionine Sulfoximine; Verapamil	1989
Pharmacokinetics of buthionine sulfoximine (NSC 326231) and its effect on melphalan-induced toxicity in mice. Cancer research, 1989, Oct-01, Volume: 49, Issue:19 Topics: Administration, Oral; Animals; Buthionine Sulfoximine; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Interactions; Glutathione; Half-Life; Injections, Intravenous; Liver; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Premedication	1989
Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. Journal of the National Cancer Institute, 1989, Apr-05, Volume: 81, Issue:7 Topics: Animals; Brain Neoplasms; Buthionine Sulfoximine; Drug Interactions; Female; Glioma; Glutathione; Humans; Male; Medulloblastoma; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Neoplasm Transplantation	1989
Detection of DNA damage in individual cells by flow cytometric analysis using anti-DNA monoclonal antibody. Experimental cell research, 1987, Volume: 170, Issue:2 Topics: Alkylating Agents; Antibodies, Monoclonal; Buthionine Sulfoximine; Cell Cycle; Cell Survival; DNA Damage; DNA, Single-Stranded; Endonucleases; Flow Cytometry; HeLa Cells; Hot Temperature; Humans; Melphalan; Methionine Sulfoximine; Nitrogen Mustard Compounds; Single-Strand Specific DNA and RNA Endonucleases	1987
Induction of hepatic veno-occlusive disease in dogs. The American journal of pathology, 1987, Volume: 126, Issue:1 Topics: Animals; Busulfan; Buthionine Sulfoximine; Cyclophosphamide; Disease Models, Animal; Dog Diseases; Dogs; Hepatic Veno-Occlusive Disease; Liver; Melphalan; Methionine Sulfoximine; Methotrexate; Monocrotaline; Pyrrolizidine Alkaloids; Radiation Injuries, Experimental; Radiography	1987
Selective enhancement of hypoxic cell killing by melphalan via thiol depletion: in vitro studies with hypoxic cell sensitizers and buthionine sulfoximine. Journal of the National Cancer Institute, 1985, Volume: 74, Issue:1 Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Etanidazole; Melphalan; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Sulfhydryl Compounds	1985
Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer. Progress in clinical and biological research, 1988, Volume: 276 Topics: Buthionine Sulfoximine; Cell Survival; Cisplatin; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms; Tumor Cells, Cultured	1988
Effect of D,L-buthionine-S,R-sulfoximine on cytotoxicity and DNA cross-linking induced by bifunctional DNA-reactive cytostatic drugs in human melanoma cells. Cancer research, 1988, Jan-01, Volume: 48, Issue:1 Topics: Antineoplastic Agents; Buthionine Sulfoximine; Cell Division; Cell Survival; Cross-Linking Reagents; DNA; Drug Synergism; Glutathione; Humans; Melanoma; Melphalan; Methionine Sulfoximine; Tumor Cells, Cultured	1988
Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. Cancer research, 1988, May-15, Volume: 48, Issue:10 Topics: Animals; Buthionine Sulfoximine; Female; Glutathione; Humans; Male; Medulloblastoma; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; Tumor Cells, Cultured	1988
Reduced thiol content in L1210 cells treated with BSO increases DNA crosslinking by melphalan. Biochemical and biophysical research communications, 1987, Apr-14, Volume: 144, Issue:1 Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Glutathione; Leukemia L1210; Melphalan; Methionine Sulfoximine; Mice; Sulfhydryl Compounds	1987
Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells. Investigational new drugs, 1986, Volume: 4, Issue:4 Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Female; Glutathione; Humans; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms; Sulfhydryl Compounds	1986
Effects of glutathione depletion on the cytotoxicity of agents toward a human colonic tumour cell line. British journal of cancer, 1987, Volume: 55, Issue:6 Topics: Antimetabolites; Antineoplastic Agents, Phytogenic; Buthionine Sulfoximine; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Naphthols; Naphthoquinones; Sesquiterpenes; Sesquiterpenes, Guaiane; Vitamin K	1987
In vivo modulation of glutathione by buthionine sulfoximine: effect on marrow response to melphalan. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7 Topics: Animals; Bone Marrow; Buthionine Sulfoximine; Drug Synergism; Female; Glutathione; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred C3H	1986
Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione. Biochemical pharmacology, 1987, Jan-01, Volume: 36, Issue:1 Topics: Animals; Buthionine Sulfoximine; Colony-Forming Units Assay; Drug Resistance; Drug Synergism; Female; Glutathione; Histocytochemistry; Humans; Melphalan; Methionine Sulfoximine; Mice; Mice, Nude; Ovarian Neoplasms	1987
Chemosensitization of L-phenylalanine mustard by the thiol-modulating agent buthionine sulfoximine. Cancer research, 1987, Mar-15, Volume: 47, Issue:6 Topics: Animals; Buthionine Sulfoximine; Drug Synergism; Glutathione; Leukemia L1210; Male; Melphalan; Methionine Sulfoximine; Mice; Thymidine	1987
Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion. Biochemical pharmacology, 1985, Jul-15, Volume: 34, Issue:14 Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Cisplatin; Doxorubicin; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms	1985
Chemosensitization: do thiols matter? International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Animals; Antineoplastic Agents; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Methionine Sulfoximine; Misonidazole; Oxygen; Radiation-Sensitizing Agents; Sulfhydryl Compounds	1984
Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion. Cancer research, 1984, Volume: 44, Issue:11 Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Cystine; Drug Resistance; Drug Synergism; Female; Glutathione; Humans; Kinetics; Melphalan; Methionine Sulfoximine; Ovarian Neoplasms	1984
Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard. Biochemical pharmacology, 1984, Feb-01, Volume: 33, Issue:3 Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Drug Resistance; Female; Glutathione; Male; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Neoplasms, Experimental	1984
Radiation resistance in a melphalan-resistant subline of a rat mammary carcinoma. Radiation research, 1994, Volume: 139, Issue:2 Topics: Animals; Buthionine Sulfoximine; Cell Cycle; Cell Division; Cell Survival; Drug Resistance; Glutathione Peroxidase; Glutathione Transferase; Mammary Neoplasms, Experimental; Melphalan; Methionine Sulfoximine; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Tumor Cells, Cultured	1994
In vivo therapeutic potential of combination thiol depletion and alkylating chemotherapy. British journal of cancer, 1993, Volume: 68, Issue:6 Topics: Alkylating Agents; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Cells; Buthionine Sulfoximine; Cell Survival; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; Drug Resistance; Female; Glutathione; Hematopoietic Stem Cells; Melphalan; Methionine Sulfoximine; Mice; Mice, Inbred C3H; Sarcoma, Experimental	1993
Glutathione depletion increases the cytotoxicity of melphalan to PC-3, an androgen-insensitive prostate cancer cell line. Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:1 Topics: Buthionine Sulfoximine; Cell Survival; Glutathione; Humans; Male; Melphalan; Methionine Sulfoximine; Prostatic Neoplasms; Tumor Cells, Cultured	1993
Characteristics of the glutathione/glutathione-S-transferase detoxification system in melphalan resistant human prostate cancer cells. The Journal of urology, 1993, Volume: 150, Issue:1 Topics: Antineoplastic Agents; Blotting, Western; Buthionine Sulfoximine; Cell Division; Dose-Response Relationship, Drug; Drug Resistance; Glutathione; Glutathione Transferase; Humans; Male; Melphalan; Methionine Sulfoximine; Prostatic Neoplasms; Tumor Cells, Cultured	1993
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007