methionine sulfoximine has been researched along with glutamine in 182 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 85 (46.70) | 18.7374 |
| 1990's | 36 (19.78) | 18.2507 |
| 2000's | 33 (18.13) | 29.6817 |
| 2010's | 22 (12.09) | 24.3611 |
| 2020's | 6 (3.30) | 2.80 |
| Authors | Studies |
|---|---|
| Alberti, KG; Blackshear, PJ; Holloway, PA | 1 |
| Karasawa, Y; Tasaki, I | 2 |
| Welbourne, TC | 1 |
| Anderson, ME; Griffith, OW; Meister, A | 1 |
| Griffith, OW; Meister, A | 1 |
| Espín, G; Mora, J; Palacios, R | 1 |
| Narins, RG; Relman, AS | 1 |
| Wadoux, P; Welbourne, TC | 1 |
| Jones, BL; Monty, KJ | 1 |
| Chien, WS; Lockau, W; Meeks, JC; Schilling, N; Shaffer, PW; Wolk, CP | 1 |
| Cooper, AJ; Meister, A; Stephani, RA | 1 |
| Alvey, TR; Brehe, JE; Burch, HB; Chan, AW | 1 |
| Ayling, PD; Betteridge, PR | 1 |
| Benjamin, AM; Quastel, JH | 1 |
| Bourke, E; Oliver, J | 1 |
| Bergman, B; Capone, DG; Carpenter, EJ; Dawson, R; Siddiqui, PJ; Söderbäck, E | 1 |
| Brusilow, SW; Hirata, T; Koehler, RC; Takahashi, H; Traystman, RJ | 1 |
| Brusilow, SW; Koehler, RC; Takahashi, H; Traystman, RJ | 2 |
| Hawkins, RA; Jessy, J | 1 |
| Battaglioli, G; Martin, DL | 1 |
| Farrow, NA; Kanamori, K; Parivar, F; Ross, BD | 1 |
| Ahluwalia, GS; Cooney, DA; Grem, JL; Hao, Z | 1 |
| Albrecht, J; Norenberg, MD | 1 |
| Baverel, G; Martin, G; Michoudet, C | 1 |
| Colanduoni, J; Villafranca, JJ | 1 |
| Placko, R; Siegel, JH; Vary, TC | 1 |
| Baverel, G; Martin, G; Vincent, N | 1 |
| Colombo, JP; Häussinger, D; Stehle, T | 1 |
| Karasawa, Y; Nakata, C | 2 |
| Durschlag, RP; Smith, RJ | 1 |
| Rothstein, JD; Tabakoff, B | 1 |
| Brown, RA; MacLennan, PA; Rennie, MJ | 1 |
| Dickson, RC; Marek, ET | 1 |
| Kanemoto, RH; Ludden, PW | 1 |
| Aronson, AI; Strauch, MA; Zalkin, H | 1 |
| Fonnum, F; Odden, E; Paulsen, RE | 1 |
| Hoop, B; Kazemi, H; Shih, VE; Systrom, DM | 1 |
| Helber, JT; Hirschberg, R; Johnson, TR; Yarbrough, LR | 1 |
| Brackett, K; Fischer, JE; James, JH; Jonung, T; Rigotti, P | 1 |
| Brosnan, JT; Lanctin, H; Ross, BD | 1 |
| Meister, A; Weisbrod, RE | 1 |
| Coghlin, J; Reif-Lehrer, L | 1 |
| Gonatas, NK; Rizzuto, N | 1 |
| Brenchley, JE; Steimer-Veale, K | 1 |
| Meister, A | 2 |
| Berger, M; Ruderman, NB | 1 |
| Meister, A; Ronzio, RA; Rowe, WB | 1 |
| Fontenelle, LJ; Henderson, JF | 1 |
| Cooney, D; Davis, R; Van Atta, G | 1 |
| Lund, P | 1 |
| Carter, SK; Cooney, DA; Livingston, RB; Venditti, JM | 1 |
| Abrams, ML; Meins, F | 1 |
| Preuss, HG; Weiss, FR | 1 |
| van den Berg, CJ; van den Velden, J | 1 |
| Lueck, JD; Miller, LL | 1 |
| Lamar, C | 1 |
| Durbin, RD; Sinden, SL | 1 |
| Azcurra, JM; Ohlsson, WG; Sellinger, OZ | 1 |
| Manning, JM; Meister, A; Moore, S; Rowe, WB | 1 |
| Haschemeyer, RH; Meister, A; Wilk, S | 1 |
| Weil-Malherbe, H | 1 |
| Neal, AL; Smulson, ME | 1 |
| Garaza, A; Sellinger, OZ | 1 |
| Massieu, GH; Ortega, BG; Pasantes, H; Pérez de la Mora, M; Tapia, R | 1 |
| Belkhode, ML; Gotto, AM; Touster, O | 1 |
| Ginsburg, A; Hunt, JB | 1 |
| Gooden, D; Premakumar, R; Sorger, GJ | 1 |
| Besagni, D; Minn, A | 1 |
| Arp, DJ; Zumft, WG | 1 |
| Chapman, JS; Meeks, JC | 1 |
| Eybalin, M; Pujol, R | 1 |
| Bonne, C; Regnault, F; Said, R; Sincholle, D | 1 |
| Duong, N; Gougoux, A; Guern, C; Khoury, N; Vinay, P | 1 |
| Anderson, PM; Casey, CA | 1 |
| Alvarez, ME; McCarthy, CM | 1 |
| Garber, BB; Gots, JS; Jochimsen, BU | 1 |
| Areas, J; Preuss, HG; Singh Aujla, M; Slemmer Gaydos, D; Vertuno, LL | 1 |
| Barrio, JR; Douglas, A; Keen, RE; Krivokapich, J; Padgett, HC; Phelps, ME; Shine, KI; Watanabe, CR | 1 |
| Fischer, JE; James, JH; Jeppsson, B; Jonung, T; Peters, JC; Rigotti, P | 1 |
| Haselkorn, R; Wood, NB | 1 |
| Herbert, RA; Macfarlane, GT | 1 |
| Preuss, HG | 1 |
| Baverel, G; Forissier, M; Genoux, C; Pellet, M | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Escalante, L; Gonzalez, R; Islas, L; Obregon, AM; Sanchez, S | 1 |
| Bryła, J; Lietz, T | 1 |
| Rennie, MJ; Tadros, LB; Taylor, PM; Willhoft, NM | 1 |
| Eisenberg, D; Liaw, SH | 1 |
| Exposito, I; Mora, F; Porras, A; Sanz, B | 1 |
| Feng, Y; Hatcher, EL; Kang, YJ | 1 |
| Dejong, CH; Deutz, NE; Heeneman, S | 1 |
| Petersen, SB; Schousboe, A; Sonnewald, U; Svendsen, JS; Unsgård, G; Westergaard, N | 1 |
| Brookes, N | 1 |
| Blei, AT; Butterworth, RF; Olafsson, S; Therrien, G | 1 |
| Deutz, NE; Heeneman, S | 1 |
| Baverel, G; Chauvin, MF; Michoudet, C | 1 |
| Bloomer, WD; Damodaran, KM; Prezioso, JA; Wang, N | 1 |
| De Joseph, MR; Hawkins, RA; Jessy, J; Mans, AM | 1 |
| Brusilow, SW; Hirata, T; Kawaguchi, T; Koehler, RC; Traystman, RJ | 1 |
| Gibbs, ME; Hertz, L; Ng, KT; O'Dowd, BS; Robinson, SR; Sedman, GL | 1 |
| Chung, JC; Kanamori, K; Kuo, EL; Ross, BD | 1 |
| Colquhoun, A; Newsholme, EA | 1 |
| Hori, S; Kaya, M; Koyama, K; Tsujita, J | 1 |
| Abcouwer, SF; Labow, BI; Lin, CM; Souba, WW | 1 |
| DeMarco, V; Dyess, K; Neu, J; Strauss, D; West, CM | 1 |
| Bains, JS; Shaw, CA | 1 |
| de Blaauw, I; Deutz, NE; Olde Damink, SW; Soeters, PB | 1 |
| Abcouwer, SF; Labow, BI; Souba, WW | 1 |
| Fliniaux, MA; Gillet-Manceau, F; Marty, D; Mesnard, F; Monti, JP | 1 |
| Barnett, NL; Pow, DV; Robinson, SR | 1 |
| Hülsmann, S; Oku, Y; Richter, DW; Zhang, W | 1 |
| Bai, G; Murthy, CR; Norenberg, MD; Rama Rao, KV | 1 |
| Blottière, H; Darmaun, D; Laboisse, C; Le Bacquer, O; Meynial-Denis, D; Nazih, H | 1 |
| Caldefie, F; Chassagne, J; Cynober, L; Moinard, C; Tridon, A; Vasson, MP; Walrand, S | 1 |
| Crespo, JL; Fowler, B; Hall, MN; Powers, T | 1 |
| McGrath-Morrow, SA; Stahl, J | 1 |
| Näsholm, T; Persson, J | 1 |
| DeMarco, V; Holliday, N; Lewis, P; Neu, J; Potsic, B; Samuelson, D | 1 |
| Cynober, L; Darquy, S; De Bandt, JP; Reach, G; Schneid, C; Torres, E | 1 |
| DeMarco, VG; Li, N; Neu, J; Thomas, J; West, CM | 1 |
| GERSHENOVICH, ZS; KOLOUSEK, J; KRICHEVSKAYA, AA | 1 |
| SELLINGER, OZ; WEILER, P | 1 |
| FOLBERGROVA, J | 2 |
| SCHENKER, S; WARREN, KS | 1 |
| LAMAR, C; SELLINGER, OZ | 1 |
| PETERS, EL; TOWER, DB | 1 |
| Ikeda, A; Saiki, S; Sonoda, Y; Yamaguchi, J; Yamaya, T | 1 |
| McDERMOTT, EE; PACE, J | 1 |
| Albrecht, J; Law, RO; Stafiej, A; Zielińska, M | 1 |
| Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Matsukawa, M; Olney, JW; Zorumski, CF | 1 |
| Richter, S; Schönig, B; Teichert, S; Tudzynski, B | 1 |
| Alonso, TJ; Castro Fuentes, R; Garcia Dopico, J; Gonzalez Hernández, T; Perdomo Diaz, J; Rodríguez Díaz, M; Sabate, M | 1 |
| Aremu, DA; Meshitsuka, S | 1 |
| Brusilow, SW; Kawaguchi, T; Koehler, RC; Traystman, RJ | 1 |
| Chew, SF; Goh, GS; Ip, YK; Leong, MW; Sim, MY; Wong, WP | 1 |
| McDonald, MD; Van Audekerke, J; Van Camp, N; Van der Linden, A; Vanhoutte, G; Veauvy, CM; Walsh, PJ | 1 |
| Harth, G; Horwitz, MA; Maslesa-Galić, S; Tullius, MV | 1 |
| Conrad, MC; Pohlmann, EL; Roberts, GP; Wolfe, DM; Zhang, Y | 1 |
| Carlson, GC; Coulter, DA; Liang, SL | 1 |
| Cooper, TG; Tate, JJ | 1 |
| Chiang, CY; Dostrovsky, JO; Hu, JW; Sessle, BJ; Wang, J; Xie, YF; Zhang, S | 1 |
| Kam, K; Nicoll, R | 1 |
| Albrecht, J; Beresewicz, A; Hilgier, W; Maczewski, M; Oja, SS; Saransaari, P; Wegrzynowicz, M | 1 |
| Huang, Z; Liang, M; Peng, J; Wang, X; Xing, T | 1 |
| Carroll, P; Parish, T; Pashley, CA | 1 |
| Fukumura, T; Hosoi, R; Inoue, O; Nakao, R; Okada, M; Suzuki, K; Zhang, MR | 1 |
| Acosta, ML; Bui, BV; Donaldson, P; Hu, RG; Kalloniatis, M; Vingrys, AJ | 1 |
| Fang, F; Jiao, YG; Li, GC; Wu, ZH | 1 |
| Bame, M; Brusilow, WS; Galloway, MP; Ghoddoussi, F; Jambekar, A; Needleman, R | 1 |
| Bidmon, HJ; Cremer, CM; Escobar, JL; Görg, B; Palomero-Gallagher, N; Speckmann, EJ; Zilles, K | 1 |
| Ballantyne, JS; Bernier, NJ; Robinson, JW; Sanderson, LA; Wright, PA | 1 |
| Albrecht, J; Norenberg, MD; Zielińska, M | 1 |
| Bak, LK; Dadsetan, S; Keiding, S; Leke, R; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS | 1 |
| Donaldson, PJ; Hu, RG; Kalloniatis, M; Lim, JC | 1 |
| Bussolati, O; Chiu, M; Comi, P; Dall'Asta, V; Franchi-Gazzola, R; Tardito, S | 1 |
| Cooper, TG; Dubois, E; Georis, I; Tate, JJ | 1 |
| Fan, L; Frye, CC; Hatfield, CC; Kadura, I; Krebs, LE; Shaw, MM | 1 |
| Dihné, M; Ferrea, S; Görg, B; Hartung, HP; Häussinger, D; Quasthoff, K; Schnitzler, A; Schwarz, CS; Walter, J | 1 |
| Chen, Z; Fan, YY; Fang, Q; He, P; Hu, WW; Ohtsu, H; Xu, TL; Xu, ZH; Yan, HJ; Yang, Y; Zhang, CY; Zhang, XN; Zhong, K | 1 |
| Han, CD; Huang, J; Je, BI; Jung, KH; Kim, TH; Lee, JJ; Liu, JM; Park, SH; Park, SJ; Piao, HL; Priatama, RA; Son, DY; Xuan, YH | 1 |
| DiNuzzo, M; Giove, F; Mangia, S; Maraviglia, B | 1 |
| Hall, MN; Jozefczuk, S; Rudroff, F; Sauer, U; Stracka, D | 1 |
| Arcangeli, A; Armeanu-Ebinger, S; Armento, A; Barilli, A; Bianchi, MG; Bussolati, O; Campanini, N; Chiu, M; Dall'Asta, V; Fuchs, J; Missale, G; Pillozzi, S; Silini, EM; Tardito, S; Uggeri, J | 1 |
| Forchhammer, K; Gloge, F; Hauf, K; Kayumov, A | 1 |
| Feary, M; Racher, AJ; Smales, CM; Young, RJ | 1 |
| Andersen, JV; McNair, LF; Schousboe, A; Waagepetersen, HS | 1 |
| Cajueiro, DBB; de Barros Pita, W; de Morais Junior, MA; Leite, FCB; Parente, DC | 1 |
| Castegna, A; De Tullio, G; Ghesquière, B; Guarini, A; Hooper, DC; Lamers, WH; Martín-Pérez, R; Mazzone, M; McVicar, DW; Menga, A; Palmieri, EM; Quinto, A; Riera-Domingo, C | 1 |
| Baek, JH; Cho, GJ; Choi, WS; Jung, DH; Kang, SS; Kim, HJ; Kim, S; Lee, DH; Lee, DK; Roh, GS; Son, H | 1 |
| Gadgil, M; Maralingannavar, V; Panchagnula, V; Parmar, D | 1 |
| Barnett, RJ; Bundy, BC; Hunt, JP; Nelson, JAD; Robinson, H; Soltani, M | 1 |
| Acewicz, A; Albrecht, J; Czarnecka, AM; Czuczwar, SJ; Kołodziej, M; Obara-Michlewska, M; Pawlik, MJ; Popek, MP; Wierzba-Bobrowicz, T; Łuszczki, J | 1 |
| Berardi, D; Chiodi, I; Mondello, C; Perini, C | 1 |
| Albrecht, J; Aldana, BI; Belfiori-Carrasco, LF; Czarnecka, AM; Obara-Michlewska, M; Pawlik, MJ; Popek, MP | 1 |
| Betenbaugh, MJ; Kraft, L; Sacco, SA; Smith, KD; Trenary, I; Tuckowski, AM; Young, JD | 1 |
| Li, B; Luo, P; Wu, J; Xian, Y; Xiao, R; Zhang, Y | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
7 review(s) available for methionine sulfoximine and glutamine
| Article | Year |
|---|---|
The control of ammonia production in the rat.
Topics: Acidosis; Acute Disease; Aminooxyacetic Acid; Ammonia; Animals; Deamination; Glutamates; Glutamine; Humans; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kidney; Kidney Cortex; Kidney Medulla; Malates; Methionine Sulfoximine; Mitochondria; Phosphates; Phosphoenolpyruvate; Rats | 1975 |
Metabolism and action of amino acid analog anti-cancer agents.
Topics: Amino Acids; Animals; Antineoplastic Agents; Aspartic Acid; Buthionine Sulfoximine; Eflornithine; Glutamine; Humans; Methionine Sulfoximine | 1990 |
An enzymatic basis for a blood-brain barrier? The gamma-glutamyl cycle-background and considerations relating to amino acid transport in the brain.
Topics: Acyltransferases; Adult; Amidohydrolases; Amino Acids; Animals; Blood-Brain Barrier; Brain; Choroid Plexus; Cysteine; gamma-Glutamyltransferase; Glutamates; Glutamine; Glutathione; Humans; Male; Methionine Sulfoximine; Mice; Peptide Synthases; Proline; Pyrrolidonecarboxylic Acid; Rabbits | 1974 |
Glutamine antagonists in chemotherapy.
Topics: Adult; Aminobutyrates; Animals; Asparaginase; Azaserine; Azo Compounds; Child; Diazooxonorleucine; Drug Combinations; Drug Interactions; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Hydroxylysine; Leukemia; Leukemia L1210; Liver; Methionine Sulfoximine; Mice; Neoplasms; Rats; RNA, Transfer | 1970 |
The specificity of glutamine synthetase and its relationship to substrate conformation at the active site.
Topics: Amino Acids; Ammonia; Aspartic Acid; Binding Sites; Cyclohexanes; Glutamates; Glutamine; Ligases; Methionine Sulfoximine; Models, Chemical | 1968 |
Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Methionine Sulfoximine; Mitochondria; Nitric Oxide | 2010 |
Does abnormal glycogen structure contribute to increased susceptibility to seizures in epilepsy?
Topics: Animals; Astrocytes; Convulsants; Disease Susceptibility; Epilepsy; Gliosis; Glucans; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Glycogen; Glycogen Synthase Kinase 3; Homeostasis; Humans; Membrane Potentials; Methionine Sulfoximine; Molecular Structure; Neurons; Potassium; Seizures; Sleep; Sleep Deprivation; Structure-Activity Relationship | 2015 |
175 other study(ies) available for methionine sulfoximine and glutamine
| Article | Year |
|---|---|
Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.
Topics: Acetates; Alanine; Alanine Transaminase; Animals; Cycloserine; Depression, Chemical; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hepatectomy; Isoleucine; Leucine; Male; Methionine Sulfoximine; Nephrectomy; Pyruvates; Rats; Starvation; Valine | 1975 |
Stimulatory effects of ammonia and glutamine on uric acid synthesis in the chicken (Gallus domesticus) treated with methionine sulfoximine.
Topics: Ammonia; Animals; Chickens; Glutamate-Ammonia Ligase; Glutamine; Kinetics; Methionine Sulfoximine; Uric Acid | 1976 |
Glutaminase-gamma-glutamyltransferase: subcellular localization and ammonia production in acidosis.
Topics: Acidosis; Ammonia; Animals; Cytosol; gamma-Glutamyltransferase; Glutaminase; Glutamine; Kidney; Male; Methionine Sulfoximine; Mitochondria; Perfusion; Rats; Solubility; Subcellular Fractions | 1978 |
Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.
Topics: Animals; Binding Sites; Glutamate-Cysteine Ligase; Glutamine; Glutathione; Kidney; Kinetics; Methionine Sulfoximine; Peptide Synthases; Rats; Structure-Activity Relationship | 1979 |
Effects of methionine sulfoximine analogs on the synthesis of glutamine and glutathione: possible chemotherapeutic implications.
Topics: Animals; Antineoplastic Agents; Binding Sites; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Glutamine; Glutathione; Methionine Sulfoximine; Rats; Structure-Activity Relationship | 1979 |
Glutamine metabolism in nitrogen-starved conidia of Neurospora crassa.
Topics: Arginine; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Mutation; Neurospora; Neurospora crassa; Nitrogen; Quaternary Ammonium Compounds | 1979 |
Ammoniagenesis: d-glutamyltransferase as a source of ammonia in the rat kidney.
Topics: Ammonia; Animals; Biological Transport; gamma-Glutamyltransferase; Glutamine; Kidney; Male; Methionine Sulfoximine; Perfusion; Rats | 1975 |
Glutamine as a feedback inhibitor of the Rhodopseudomonas sphaeroides nitrogenase system.
Topics: Ammonia; Feedback; Glutamine; Kinetics; Methionine Sulfoximine; Nitrogenase; Rhodobacter sphaeroides | 1979 |
Pathways of assimilation of [13N]N2 and 13NH4+ by cyanobacteria with and without heterocysts.
Topics: Alanine; Ammonia; Citrulline; Cyanobacteria; Glutamates; Glutamine; Methionine Sulfoximine; Nitrogen Fixation; Species Specificity | 1978 |
Enzymatic reactions of methionine sulfoximine. Conversion to the corresponding alpha-imino and alpha-keto acids and to alpha-ketobutyrate and methane sulfinimide.
Topics: Amino Acid Oxidoreductases; Animals; Carboxylic Acids; Cystathionine gamma-Lyase; Glutamine; Imines; Keto Acids; Kinetics; Lyases; Magnetic Resonance Spectroscopy; Methionine; Methionine Sulfoximine; Snakes; Transaminases | 1976 |
Effect of methionine sulfoximine on glutathione and amino acid levels in the nephron.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Glutamates; Glutamine; Glutathione; Kidney; Kidney Cortex; Kidney Glomerulus; Kidney Medulla; Kidney Tubules; Male; Methionine Sulfoximine; Nephrons; Rats | 1976 |
The role of methionine transport-defective mutations in resistance to methionine sulphoximine in Salmonella typhimurium.
Topics: Biological Transport; Chromosome Mapping; Chromosomes, Bacterial; Conjugation, Genetic; Drug Resistance, Microbial; Glutamine; Methionine; Methionine Sulfoximine; Mutation; Salmonella typhimurium | 1975 |
Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: a possible role of ammonia in brain function.
Topics: Age Factors; Amino Acids; Aminooxyacetic Acid; Ammonia; Amobarbital; Animals; Cerebral Cortex; Dinitrophenols; Female; Fluoroacetates; Glucose; Glutamates; Glutamine; In Vitro Techniques; Male; Malonates; Methionine Sulfoximine; Ouabain; Oxygen Consumption; Proteins; Rats; Synaptosomes | 1975 |
Adaptations in metabolic acidosis: a reinterpretation.
Topics: Acidosis; Ammonium Chloride; Animals; Bicarbonates; Glutamine; Guinea Pigs; Hydrochloric Acid; Kidney; Methionine Sulfoximine; Quaternary Ammonium Compounds; Rats; Urea | 1975 |
Glutamine synthetase and nitrogen cycling in colonies of the marine diazotrophic cyanobacteria Trichodesmium spp.
Topics: Animals; Bacterial Proteins; Cyanobacteria; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Methionine Sulfoximine; Nitrogen Fixation; Seawater; Water Microbiology | 1992 |
Restoration of cerebrovascular CO2 responsivity by glutamine synthesis inhibition in hyperammonemic rats.
Topics: Ammonia; Animals; Carbon Dioxide; Cerebrovascular Circulation; Glutamine; Hypercapnia; Hypocapnia; Male; Methionine Sulfoximine; Rats; Rats, Wistar | 1992 |
Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats.
Topics: Acetates; Acetic Acid; Ammonia; Animals; Blood Pressure; Brain Edema; Carbon Dioxide; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hemoglobins; Hydrogen-Ion Concentration; Male; Methionine Sulfoximine; Osmolar Concentration; Oxygen; Partial Pressure; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Hyperammonaemia does not impair brain function in the absence of net glutamine synthesis.
Topics: Amino Acids; Ammonia; Animals; Biological Transport; Brain; Dose-Response Relationship, Drug; Energy Metabolism; Glucose; Glutamine; Male; Methionine Sulfoximine; Phosphates; Rats; Time Factors; Tryptophan | 1991 |
GABA synthesis in brain slices is dependent on glutamine produced in astrocytes.
Topics: 4-Aminobutyrate Transaminase; Animals; Astrocytes; Brain; Cyclohexanecarboxylic Acids; Diazooxonorleucine; gamma-Aminobutyric Acid; Glutaminase; Glutamine; Kinetics; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
A 15N-n.m.r. study of cerebral, hepatic and renal nitrogen metabolism in hyperammonaemic rats.
Topics: Adenosine Triphosphate; Alanine; Ammonia; Animals; Brain; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Inactivation, Metabolic; Kidney; Liver; Magnetic Resonance Spectroscopy; Male; Methionine Sulfoximine; Nitrogen; Nitrogen Isotopes; Phosphocreatine; Rats; Rats, Inbred Strains; Urea | 1990 |
Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia.
Topics: Acetates; Acetic Acid; Ammonia; Animals; Brain Edema; Cerebral Cortex; Glutamate-Ammonia Ligase; Glutamine; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Specific Gravity | 1990 |
L-methionine-DL-sulfoximine induces massive efflux of glutamine from cortical astrocytes in primary culture.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bucladesine; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamine; Methionine Sulfoximine; Rats | 1990 |
Glutamine synthesis from aspartate in guinea-pig renal cortex.
Topics: Aminooxyacetic Acid; Ammonium Chloride; Animals; Aspartate Aminotransferases; Aspartic Acid; Carbon Radioisotopes; Coumaric Acids; Fluoroacetates; Glutamate Dehydrogenase; Glutamine; Guinea Pigs; Kidney Tubules; Methionine Sulfoximine; Nitrogen; Oxaloacetates; Quinolinic Acids | 1990 |
Labeling of specific lysine residues at the active site of glutamine synthetase.
Topics: Adenosine; Adenosine Triphosphate; Amino Acids; Binding Sites; Escherichia coli; Glutamate-Ammonia Ligase; Glutamine; Homoarginine; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mathematics; Methionine Sulfoximine; Pyridoxal Phosphate; Spectrometry, Fluorescence; Thiourea | 1985 |
Pharmacologic modulation of increased release of gluconeogenic precursors from extra-splanchnic organs in sepsis.
Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Cycloserine; Dichloroacetic Acid; Gluconeogenesis; Glutamate-Ammonia Ligase; Glutamine; Hepatectomy; Intestine, Small; Lactates; Lactic Acid; Liver; Male; Methionine Sulfoximine; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Sepsis | 1989 |
Simultaneous synthesis and degradation of glutamine in isolated rat liver cells. Effect of vasopressin.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kinetics; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Vasopressins | 1989 |
Benzoate stimulates glutamate release from perfused rat liver.
Topics: Ammonium Chloride; Animals; Benzoates; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Methionine Sulfoximine; Models, Biological; Perfusion; Potassium; Rats; Rats, Inbred Strains | 1989 |
Incorporation of intraportally infused [15N]ammonia into urinary uric acid in cockerels pretreated with methionine sulfoximine.
Topics: Ammonia; Animals; Chickens; Glutamate-Ammonia Ligase; Glutamine; Infusions, Intravenous; Kidney; Liver; Male; Methionine Sulfoximine; Portal Vein; Uric Acid | 1989 |
Regulation of glutamine production by skeletal muscle cells in culture.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Methionine Sulfoximine; Muscles; Rats; Rats, Inbred Strains | 1985 |
Regulation of neurotransmitter aspartate metabolism by glial glutamine synthetase.
Topics: Analysis of Variance; Animals; Aspartic Acid; Glutamate-Ammonia Ligase; Glutamine; Male; Methionine Sulfoximine; Neuroglia; Rats; Rats, Inbred Strains | 1986 |
A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle.
Topics: Animals; Female; Glutamate-Ammonia Ligase; Glutamine; Insulin; Intracellular Fluid; Methionine Sulfoximine; Muscle Proteins; Muscles; Perfusion; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1987 |
Cloning and characterization of Saccharomyces cerevisiae genes that confer L-methionine sulfoximine and tabtoxin resistance.
Topics: Biological Transport; Dipeptides; Drug Resistance, Microbial; Gene Expression Regulation; Genes, Fungal; Genetic Vectors; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Saccharomyces cerevisiae | 1987 |
Amino acid concentrations in Rhodospirillum rubrum during expression and switch-off of nitrogenase activity.
Topics: Amino Acids; Ammonia; Azaserine; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Light; Methionine Sulfoximine; Methylphenazonium Methosulfate; Nitrogen; Nitrogenase; Rhodospirillum | 1987 |
Characterization of the glutamyl-tRNA(Gln)-to-glutaminyl-tRNA(Gln) amidotransferase reaction of Bacillus subtilis.
Topics: Ammonia; Asparagine; Bacillus subtilis; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutamine; Hot Temperature; Methionine Sulfoximine; Mutation; Nitrogenous Group Transferases; RNA, Transfer, Amino Acyl; RNA, Transfer, Gln; Transferases | 1988 |
Importance of glutamine for gamma-aminobutyric acid synthesis in rat neostriatum in vivo.
Topics: Aminocaproates; Animals; Citrates; Citric Acid Cycle; Corpus Striatum; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamine; Male; Methionine Sulfoximine; Neuroglia; Rats; Rats, Inbred Strains; Vigabatrin | 1988 |
Central respiratory effects of glutamine synthesis inhibition in dogs.
Topics: Animals; Central Nervous System; Chemoreceptor Cells; Dogs; Female; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Models, Biological; Neurotransmitter Agents; Respiration | 1988 |
Effects of varying doses of methionine sulfoximine on liver glutamine synthetase activity and time courses of blood and urinary nitrogenous compounds in the chicken (Gallus domesticus).
Topics: Ammonia; Animals; Chickens; Dose-Response Relationship, Drug; Glutamate-Ammonia Ligase; Glutamine; Kinetics; Liver; Male; Methionine Sulfoximine; Nitrogen; Uric Acid | 1988 |
Effect of nitrogenous compounds on nitrogenase gene expression in anaerobic cultures of Anabaena variabilis.
Topics: Ammonia; Anaerobiosis; Carbamyl Phosphate; Cyanobacteria; Gene Expression Regulation; Genes, Bacterial; Glutamates; Glutamine; Methionine Sulfoximine; Nitrates; Nitrogen; Nitrogen Fixation; Nitrogenase; Nucleic Acid Hybridization; RNA, Messenger; Transcription, Genetic | 1988 |
Effect of hyperammonemia and methionine sulfoximine on the kinetic parameters of blood-brain transport of leucine and phenylalanine.
Topics: Ammonia; Animals; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Glutamine; Kinetics; Leucine; Male; Methionine Sulfoximine; Microscopy, Electron; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains | 1985 |
Glutamine synthesis in the perfused rat kidney and in isolated rat cortical tubules: regulation by pH.
Topics: Ammonia; Animals; Gluconeogenesis; Glucose; Glutamates; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tubules; Kinetics; Male; Methionine Sulfoximine; Perfusion; Rats; Rats, Inbred Strains | 1985 |
Studies on glutamine synthetase from Escherichia coli. Formation of pyrrolidone carboxylate and inhibition by methionine sulfoximine.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Brain; Escherichia coli; Glutamate-Ammonia Ligase; Glutamine; Kinetics; Magnesium; Manganese; Methionine Sulfoximine; Protein Binding; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Sheep; Species Specificity; Stereoisomerism | 1973 |
Conversion of glutamic acid to glutamine by retinal glutamine synthetase.
Topics: Age Factors; Animals; Carbon Radioisotopes; Cattle; Chick Embryo; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hydrocortisone; In Vitro Techniques; Methionine Sulfoximine; Retina; Tritium | 1973 |
Ultrastructural study of effect of methionine sulfoximine on developing and adult rat cerebral cortex.
Topics: Animals; Brain; Brain Edema; Cerebral Cortex; Dose-Response Relationship, Drug; Female; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Male; Methionine Sulfoximine; Microscopy, Electron; Motor Cortex; Neuroglia; Rats; Seizures; Synaptic Membranes; Synaptic Transmission; Synaptic Vesicles | 1974 |
Characterization of Salmonella typhimurium strains sensitive and resistant to methionine sulfoximine.
Topics: Cell-Free System; Drug Resistance, Microbial; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Methionine; Methionine Sulfoximine; Mutation; Salmonella typhimurium; Stereoisomerism; Transaminases | 1974 |
Effect of methionine sulfoximine on glutamine synthetase activity and blood metabolite levels in the chicken (Gallus domesticus).
Topics: Ammonia; Animals; Brain; Chickens; Glutamate-Ammonia Ligase; Glutamine; Heart; Intestine, Small; Kidney; Liver; Male; Methionine Sulfoximine; Myocardium; Organ Specificity; Spectrophotometry, Ultraviolet; Uric Acid | 1974 |
The formation of glutamine and alanine in skeletal muscle.
Topics: Alanine; Amino Acids; Animals; Arteries; Diabetes Mellitus; Electric Stimulation; Fasting; Female; Glucagon; Glutamine; Glycine; Hindlimb; Humans; Insulin; Lactates; Methionine Sulfoximine; Muscles; Perfusion; Physical Exertion; Proline; Rats; Regional Blood Flow; Streptozocin; Valine; Veins | 1974 |
Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Ammonia; Animals; Binding Sites; Brain; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Drug Stability; Electrophoresis; Glutamates; Glutamine; Hydroxylamines; Kinetics; Ligases; Magnesium; Manganese; Methionine; Methionine Sulfoximine; Phosphates; Phosphoric Monoester Hydrolases; Phosphorus Isotopes; Protein Binding; Sheep; Sulfones | 1969 |
Sources of nitrogen as rate-limiting factors for purine biosynthesis de novo in Ehrlich ascites tumor cells.
Topics: Adenine; Ammonia; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Diphosphates; Drug Synergism; Glutamine; Glycine; Hypoxanthines; Kinetics; Ligases; Methionine Sulfoximine; Nitrogen; Nucleotides; Pentosephosphates; Purines; Transferases | 1969 |
A spectrophotometric method for the simultaneous measurement of L-glutamine and L-asparagine in biological materials.
Topics: Aminohydrolases; Ammonia; Animals; Arginine; Asparagine; Brain; Escherichia coli; Evaluation Studies as Topic; Glutamate Dehydrogenase; Glutamine; Hot Temperature; Humans; Ketoglutaric Acids; Liver; Methionine Sulfoximine; Methods; Mice; NAD; Peptide Hydrolases; Spectrophotometry; Time Factors; Trichloroacetic Acid | 1971 |
Control of glutamine synthesis in rat liver.
Topics: Alanine; Amino Acids; Ammonia; Animals; Brain; Cyanides; Female; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hydroxylysine; In Vitro Techniques; Liver; Methionine Sulfoximine; Perfusion; Proline; Rats; Starvation | 1971 |
How methionine and glutamine prevent inhibition of growth by methionine sulfoximine.
Topics: Biological Transport; Carbon Isotopes; Chlorella; Chlorophyta; Drug Resistance, Microbial; Glutamine; Kinetics; Methionine; Methionine Sulfoximine | 1972 |
Glutamine synthetase and plasma glutamine in augmented ammoniagenesis in acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Ammonia; Animals; Glutamine; Hydrogen-Ion Concentration; Ligases; Liver; Male; Methionine Sulfoximine; Rats; Transferases | 1970 |
The effect of methionine sulphoximine on the incorporation of labelled glucose, acetate, phenylalanine and proline into glutamate and related amino acids in the brains of mice.
Topics: Acetates; Amino Acids; Animals; Brain; Carbon Isotopes; Glucose; Glutamates; Glutamine; Ligases; Male; Methionine; Methionine Sulfoximine; Mice; Phenylalanine; Proline | 1970 |
The effect of perfusate pH on glutamine metabolism in the isolated perfused rat liver.
Topics: Acidosis; Animals; Carbon Dioxide; Carbon Isotopes; Carbonates; Glucose; Glutamates; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoglutaric Acids; Lactates; Ligases; Liver; Male; Metabolism; Methionine Sulfoximine; Oxidation-Reduction; Perfusion; Rats; Urea | 1970 |
The duration of the inhibtion of glutamine synthetase by methionine sulfoximine.
Topics: Animals; Brain; Carbon Isotopes; Glutamine; Kidney; Ligases; Liver; Male; Methionine; Methionine Sulfoximine; Rats; Time Factors; Transaminases | 1968 |
Glutamine synthetase inhibition: possible mode of action of wildfire toxin from Pseudomonas tabaci.
Topics: Antitoxins; Chlorophyll; Depression, Chemical; Glutamine; Kinetics; Ligases; Methionine; Methionine Sulfoximine; Nicotiana; Plant Diseases; Plant Proteins; Plants, Edible; Plants, Toxic; Pseudomonas; RNA; Toxins, Biological; Transferases | 1968 |
Methionine sulfoximine seizures. 8. The dissociation of the convulsant and glutamine synthetase inhibitory effects.
Topics: Animals; Brain Chemistry; Cerebellum; Cerebral Cortex; Glutamine; Heart Ventricles; Hypothalamus; Injections; Injections, Intraperitoneal; Methionine; Methionine Sulfoximine; Rats; Seizures; Thalamus; Transferases | 1968 |
Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Autoanalysis; Brain; Carbon Isotopes; Chromatography, Ion Exchange; Glutamine; Leucine; Ligases; Magnesium; Methionine; Methionine Sulfoximine; Models, Structural; Phosphates; Sheep; Stereoisomerism | 1969 |
Studies on the subunit structure of ovine brain glutamine synthetase.
Topics: Adenosine Triphosphate; Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, Gel; Dextrans; Dimethyl Sulfoxide; Dimethylformamide; Ethylmaleimide; Glutamine; Hydrogen-Ion Concentration; Hydroxamic Acids; Ligases; Magnesium; Methionine Sulfoximine; Molecular Weight; Optical Rotatory Dispersion; Sheep; Sulfhydryl Compounds; Temperature; Ultracentrifugation; Urea | 1969 |
Activators and inhibitors of brain glutaminase.
Topics: Acids; Amino Acids; Animals; Brain; Bromides; Centrifugation; Chlorides; Citrates; Citric Acid Cycle; Dicarboxylic Acids; Enzyme Induction; Enzyme Repression; Fluorides; Glutaminase; Glutamine; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Iodides; Methionine Sulfoximine; Phosphates; Phosphocreatine; Sulfhydryl Compounds | 1969 |
Comparative effects of glutamine analogues on protein metabolism of 6C3H-ED and Ehrlich ascites carcinoma.
Topics: Amides; Animals; Azaserine; Azides; Carcinoma, Ehrlich Tumor; Diazooxonorleucine; Glutamine; Hydroxamic Acids; In Vitro Techniques; Isoleucine; Lymphoma, Non-Hodgkin; Methionine; Methionine Sulfoximine; Neoplasm Proteins; Sarcoma, Experimental; Valine | 1965 |
The inhibition of cerebral glutamine synthetase by structural analogs of the convulsant dl-methionine sulfoximine.
Topics: Animals; Cerebral Cortex; Cysteine; Enzymes; Glutamine; Homocysteine; In Vitro Techniques; Ligases; Methionine; Methionine Sulfoximine; Rats | 1966 |
Free amino acids and glutamate decarboxylase activity in brain of mice during drug-induced convulsions.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Carboxy-Lyases; Glutamates; Glutamine; Hydrazines; Insulin; Methionine; Methionine Sulfoximine; Mice; Pentylenetetrazole; Pyridoxal Phosphate; Seizures; Thiosemicarbazones; Transaminases | 1967 |
On the mechanism of the nucleoside stimulation of amino acid incorporation into protein of Ehrlich ascites tumor cells in vitro.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Dactinomycin; Glucose; Glutamates; Glutamine; Glycine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Ligases; Methionine; Methionine Sulfoximine; Neoplasm Proteins; Nucleosides; Pentosephosphates; Uracil; Uridine | 1967 |
Mn2+ and substrate interactions with glutamine synthetase from Escherichia coli.
Topics: Adenosine Diphosphate; Binding Sites; Escherichia coli; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Kinetics; Manganese; Methionine Sulfoximine; Protein Binding | 1980 |
Repression of nitrate reductase in Neurospora studied by using L-methionine-DL-sulfoximine and glutamine auxotroph gln-1b.
Topics: Enzyme Repression; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Neurospora; Nitrate Reductases; Quaternary Ammonium Compounds | 1980 |
Uptake of L-glutamine into synaptosomes. Is the gamma-glutamyl cycle involved?
Topics: Amino Acids; Animals; Biological Transport; Cerebral Cortex; gamma-Glutamyltransferase; Glutamine; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Sodium; Synaptosomes | 1983 |
L-methionine-SR-sulfoximine as a probe for the role of glutamine synthetase in nitrogenase switch-off by ammonia and glutamine in Rhodopseudomonas palustris.
Topics: Ammonia; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Nitrogenase; Rhodopseudomonas | 1983 |
Glutamine and glutamate transport by Anabaena variabilis.
Topics: Biological Transport; Cyanobacteria; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Kinetics; Methionine Sulfoximine; Mutation | 1983 |
A radioautographic study of [3H]L-glutamate and [3H]L-glutamine uptake in the guinea-pig cochlea.
Topics: Absorption; Animals; Autoradiography; Cochlea; Glutamates; Glutamic Acid; Glutamine; Guinea Pigs; Hair Cells, Auditory; In Vitro Techniques; Methionine Sulfoximine; Neurotransmitter Agents; Sodium | 1983 |
In vitro study of gamma-glutamyl transpeptidase in rat lens.
Topics: Animals; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutamates; Glutamine; Glutathione; Lens, Crystalline; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Serine | 1983 |
Renal recovery from metabolic acidosis in the rat: no role for glutamine synthetase.
Topics: Acidosis; Alkalosis; Ammonia; Animals; Bicarbonates; Glutamate-Ammonia Ligase; Glutamine; Kidney; Methionine Sulfoximine; Mitochondria; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Glutamine-dependent synthesis of citrulline by isolated hepatic mitochondria from Squalus acanthias.
Topics: Ammonia; Ammonium Chloride; Animals; Citrulline; Dogfish; Glutamates; Glutamic Acid; Glutamine; Isoxazoles; Methionine Sulfoximine; Mitochondria, Liver | 1984 |
Glutamine synthetase from Mycobacterium avium.
Topics: Ammonium Chloride; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Isoelectric Point; Methionine Sulfoximine; Molecular Weight; Mycobacterium; Mycobacterium avium; Peptides; Temperature | 1984 |
Glutamine and related analogs regulate guanosine monophosphate reductase in Salmonella typhimurium.
Topics: Azo Compounds; Bacterial Proteins; Diazooxonorleucine; Enzyme Induction; Glutamine; GMP Reductase; Guanosine; Guanosine Monophosphate; Methionine Sulfoximine; NADH, NADPH Oxidoreductases; Salmonella typhimurium | 1980 |
In vitro correlation of glutamine and glutamate renal ammoniagenesis during adaptation.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Ammonia; Animals; Glutamates; Glutamine; In Vitro Techniques; Kidney; Male; Methionine Sulfoximine; Rats | 1984 |
Kinetic characterization of 13NH3 and [13N]glutamine metabolism in rabbit heart.
Topics: Ammonia; Animals; Chromatography, High Pressure Liquid; Glutamine; Kinetics; Male; Methionine Sulfoximine; Myocardium; Nitrogen Radioisotopes; Rabbits | 1984 |
Methionine sulfoximine prevents the accumulation of large neutral amino acids in brain of hyperammonemic rats.
Topics: Amino Acids; Ammonia; Animals; Biological Transport; Blood-Brain Barrier; Brain; Glutamine; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1984 |
Control of phycobiliprotein proteolysis and heterocyst differentiation in Anabaena.
Topics: Adenosine Triphosphate; Cyanobacteria; Endopeptidases; Enzyme Induction; Glutamine; Light; Light-Harvesting Protein Complexes; Methionine; Methionine Sulfoximine; Plant Proteins | 1980 |
Asparagine and glutamine metabolism in Rhodopseudomonas acidophila.
Topics: Asparaginase; Asparagine; Glutaminase; Glutamine; Glycine; Glyoxylates; Methionine Sulfoximine; Rhodopseudomonas; Transaminases | 1980 |
The effects of alpha-methylglutamate on ammonium excretion and renal ammonia production in rats.
Topics: Ammonia; Animals; Glutamates; Glutamine; Kidney; Male; Methionine Sulfoximine; Mitochondria; Rats | 1980 |
Fate of glutamate carbon and nitrogen in isolated guinea-pig kidney-cortex tubules. Evidence for involvement of glutamate dehydrogenase in glutamine sythesis from glutamate.
Topics: Aminooxyacetic Acid; Animals; Carbon; Female; Glutamate Dehydrogenase; Glutamates; Glutamine; Guinea Pigs; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Kinetics; Methionine Sulfoximine; Nitrogen | 1980 |
Astrocyte swelling in liver failure: role of glutamine and benzodiazepines.
Topics: Ammonia; Animals; Animals, Newborn; Astrocytes; Brain Edema; Cells, Cultured; Cerebral Cortex; Chlorides; GABA-A Receptor Antagonists; Glutamate-Ammonia Ligase; Glutamine; Hepatic Encephalopathy; Inositol; Ion Channels; Isoquinolines; Methionine Sulfoximine; Potassium; Rats; Receptors, GABA-A; Water-Electrolyte Balance | 1994 |
Gentamicin formation in Micromonospora purpurea: stimulatory effect of ammonium.
Topics: Ammonium Chloride; Fermentation; Gentamicins; Glutamic Acid; Glutamine; Methionine Sulfoximine; Micromonospora | 1995 |
Glycerol and lactate induce reciprocal changes in glucose formation and glutamine production in isolated rabbit kidney-cortex tubules incubated with aspartate.
Topics: Amino Acids; Ammonia; Animals; Aspartic Acid; Gluconeogenesis; Glucose; Glutamine; Glycerol; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Kinetics; Lactates; Lactic Acid; Methionine Sulfoximine; Models, Biological; Rabbits | 1995 |
Effects of glutamine deprivation on glutamine transport and synthesis in primary culture of rat skeletal muscle.
Topics: Amino Acids; Animals; Animals, Newborn; Asparagine; Biological Transport; Cell Differentiation; Cell Division; Cells, Cultured; Cycloheximide; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Histidine; Insulin; Kinetics; Methionine Sulfoximine; Muscles; Rats; Time Factors; Tritium | 1993 |
Structural model for the reaction mechanism of glutamine synthetase, based on five crystal structures of enzyme-substrate complexes.
Topics: Adenylyl Imidodiphosphate; Crystallography, X-Ray; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Methionine Sulfoximine; Models, Chemical; Models, Molecular; Protein Conformation; Quaternary Ammonium Compounds; Salmonella typhimurium | 1994 |
Effects of apomorphine and L-methionine sulphoximine on the release of excitatory amino acid neurotransmitters and glutamine in the striatum of the conscious rat.
Topics: Analysis of Variance; Animals; Apomorphine; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Glutamine; Haloperidol; Kinetics; Male; Methionine Sulfoximine; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1994 |
Glutathione stimulates A549 cell proliferation in glutamine-deficient culture: the effect of glutamate supplementation.
Topics: Buthionine Sulfoximine; Cell Division; Cysteine; gamma-Glutamyltransferase; Glutamates; Glutamine; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Tumor Cells, Cultured | 1994 |
Effects of methionine sulphoximine treatment on renal amino acid and ammonia metabolism in rats.
Topics: Amino Acids; Ammonia; Animals; Body Weight; Eating; Glutamine; Kidney; Male; Methionine Sulfoximine; Rats; Rats, Wistar; Renal Circulation; Renal Plasma Flow | 1994 |
Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons.
Topics: Acetates; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glucose; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Mice; Neurons | 1993 |
Interaction between the glutamine cycle and the uptake of large neutral amino acids in astrocytes.
Topics: Amino Acids; Ammonia; Animals; Astrocytes; Glutamates; Glutamic Acid; Glutamine; Kynurenine; Methionine Sulfoximine; Mice; Phenylalanine | 1993 |
Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis.
Topics: Ammonia; Animals; Blood Pressure; Body Water; Brain Edema; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamates; Glutamine; Intracranial Pressure; Male; Methionine Sulfoximine; Portacaval Shunt, Surgical; Pseudotumor Cerebri; Rats; Rats, Sprague-Dawley | 1994 |
Effects of decreased glutamine supply on gut and liver metabolism in vivo in rats.
Topics: Amino Acids; Ammonia; Animals; Glutamine; Intestinal Mucosa; Intestines; Liver; Male; Methionine Sulfoximine; Rats | 1993 |
Glutamine synthesis from glucose and ammonium chloride by guinea-pig kidney tubules.
Topics: Ammonium Chloride; Animals; Bicarbonates; Carbon Dioxide; Carbon Radioisotopes; Glucose; Glutamine; Guinea Pigs; Kidney Tubules; Lactates; Lactic Acid; Methionine Sulfoximine; Oxidation-Reduction; Pentose Phosphate Pathway; Phosphofructokinase-1; Pyruvate Carboxylase | 1994 |
Mechanism(s) regulating inhibition of thymidylate synthase and growth by gamma-L-glutaminyl-4-hydroxy-3-iodobenzene, a novel melanin precursor, in melanogenic melanoma cells.
Topics: Animals; Biotransformation; Buthionine Sulfoximine; Cell Division; Glutamine; Glutathione; GTP Phosphohydrolases; Humans; Melanins; Melanoma; Methionine Sulfoximine; Mice; Monophenol Monooxygenase; Oxidation-Reduction; Phenols; Protein Precursors; Tetrazolium Salts; Thiazoles; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy.
Topics: Animals; Brain; Glutamine; Hepatic Encephalopathy; Male; Methionine Sulfoximine; Portacaval Shunt, Surgical; Postoperative Period; Rats; Rats, Inbred Strains | 1993 |
Impaired pial arteriolar reactivity to hypercapnia during hyperammonemia depends on glutamine synthesis.
Topics: Acetates; Acetic Acid; Ammonia; Animals; Arterioles; Astrocytes; Blood Pressure; Buthionine Sulfoximine; Cerebrovascular Circulation; Enzyme Inhibitors; Glutamine; Hypercapnia; Infusions, Intravenous; Male; Methionine Sulfoximine; Pia Mater; Rats; Rats, Wistar; Reference Values; Regional Blood Flow | 1996 |
Inhibition of glutamine synthetase activity prevents memory consolidation.
Topics: Alanine; Animals; Avoidance Learning; Chickens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Ketoglutaric Acids; Male; Memory; Methionine Sulfoximine; Neuroglia; Sodium Glutamate; Time Factors | 1996 |
Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.
Topics: Ammonia; Animals; Brain; Glutamate-Ammonia Ligase; Glutamine; Hepatic Encephalopathy; Kinetics; Male; Methionine Sulfoximine; Motor Activity; Posture; Rats; Rats, Wistar; Reflex; Time Factors | 1996 |
Aspects of glutamine metabolism in human tumour cells.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Division; Culture Media; Dose-Response Relationship, Drug; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Humans; Male; Methionine Sulfoximine; Phosphates; Purines; Pyrimidines; Rats; Rats, Wistar; Thymidine; Tritium; Tumor Cells, Cultured | 1997 |
Effects of decreased plasma glutamine concentrations on peripheral lymphocyte proliferation in rats.
Topics: Amino Acids; Animals; Concanavalin A; Corticosterone; DNA; Glutamine; Lymphocyte Activation; Male; Methionine Sulfoximine; Physical Exertion; Rats; Rats, Wistar; T-Lymphocytes; Urea | 1998 |
Glutamine synthetase expression in rat lung is regulated by protein stability.
Topics: Animals; Dexamethasone; Enzyme Stability; Feedback; Gene Expression Regulation, Enzymologic; Glucocorticoids; Glutamate-Ammonia Ligase; Glutamine; Lung; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Inhibition of glutamine synthetase decreases proliferation of cultured rat intestinal epithelial cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Inhibitors; Extracellular Space; Glutamate-Ammonia Ligase; Glutamine; Intestinal Mucosa; Methionine Sulfoximine; Osmolar Concentration; Rats | 1999 |
Did consumption of flour bleached by the agene process contribute to the incidence of neurological disease?
Topics: Buthionine Sulfoximine; Chlorides; Flour; Food Contamination; Food Handling; Glutamine; Glutathione; Humans; Methionine Sulfoximine; Models, Neurological; Nervous System; Neurodegenerative Diseases; Nitrogen Compounds; Oxidative Stress | 1998 |
Effects in vivo of decreased plasma and intracellular muscle glutamine concentration on whole-body and hindquarter protein kinetics in rats.
Topics: Amino Acids; Animals; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Male; Methionine Sulfoximine; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Wistar; Specific Pathogen-Free Organisms | 1999 |
Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms.
Topics: Animals; Dexamethasone; Enzyme Inhibitors; Glucocorticoids; Glutamate-Ammonia Ligase; Glutamine; Male; Methionine Sulfoximine; Muscle, Skeletal; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1999 |
Glutamine synthetase activity in Solanaceous cell suspensions accumulating alkaloids or not. 13C NMR and enzymatic assay.
Topics: Alkaloids; Cells, Cultured; Datura stramonium; Enzyme Induction; Enzyme Inhibitors; gamma-Aminobutyric Acid; Gene Expression Regulation, Plant; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Nicotiana; Plant Proteins; Plants, Medicinal; Plants, Toxic; Species Specificity; Suspensions | 1999 |
Inhibition of Müller cell glutamine synthetase rapidly impairs the retinal response to light.
Topics: Analysis of Variance; Animals; Buthionine Sulfoximine; Electroretinography; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Immunohistochemistry; Light; Methionine Sulfoximine; Rats; Rats, Wistar; Retina; Time Factors | 2000 |
Metabolic coupling between glia and neurons is necessary for maintaining respiratory activity in transverse medullary slices of neonatal mouse.
Topics: Animals; Animals, Newborn; Antimetabolites; Depression, Chemical; Female; Fluoroacetates; Glutamine; In Vitro Techniques; Isocitrates; Male; Medulla Oblongata; Methionine Sulfoximine; Mice; Nerve Net; Neuroglia; Neurons; Respiratory Mechanics | 2000 |
Ammonia-induced production of free radicals in primary cultures of rat astrocytes.
Topics: Ammonium Chloride; Animals; Astrocytes; Catalase; Cells, Cultured; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Fluorometry; Free Radicals; Glutamate-Ammonia Ligase; Glutamine; Hyperammonemia; Lipid Peroxidation; Methionine Sulfoximine; Nerve Tissue Proteins; Rats; Superoxide Dismutase | 2001 |
Effects of glutamine deprivation on protein synthesis in a model of human enterocytes in culture.
Topics: Apolipoproteins A; Caco-2 Cells; Culture Media; Deuterium; Enterocytes; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Glutamate-Ammonia Ligase; Glutamine; Humans; Kinetics; Methionine Sulfoximine; Protein Biosynthesis | 2001 |
Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines.
Topics: Animals; Arginine; Chemotaxis, Leukocyte; Dexamethasone; Eflornithine; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Hydrogen Peroxide; Isothiuronium; Male; Methionine Sulfoximine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Sprague-Dawley; Respiratory Burst; Stress, Psychological | 2002 |
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carrier Proteins; Cation Transport Proteins; DNA-Binding Proteins; Enzyme Inhibitors; Fungal Proteins; Gene Expression; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Intracellular Fluid; Methionine Sulfoximine; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Trans-Activators; Transcription Factors | 2002 |
Inhibition of glutamine synthetase in a549 cells during hyperoxia.
Topics: Antimetabolites; Buthionine Sulfoximine; Cell Division; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Humans; Hyperoxia; Methionine Sulfoximine; Oxygen; Respiratory Mucosa | 2002 |
Regulation of amino acid uptake in conifers by exogenous and endogenous nitrogen.
Topics: Adaptation, Physiological; Amino Acids; Aminooxyacetic Acid; Azaserine; Enzyme Inhibitors; Glutamate Synthase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Methionine Sulfoximine; Nitrate Reductase; Nitrate Reductases; Nitrates; Nitrogen; Plant Roots; Quaternary Ammonium Compounds; Tracheophyta; Transaminases; Tungsten Compounds; Up-Regulation | 2002 |
Glutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphology.
Topics: Amino Acids; Animals; Body Weight; Dietary Supplements; Electrolytes; Female; Glucose; Glutamate-Ammonia Ligase; Glutamine; Humans; Intestinal Mucosa; Intestine, Small; Methionine Sulfoximine; Parenteral Nutrition; Parenteral Nutrition Solutions; Random Allocation; Rats; Rats, Sprague-Dawley; Solutions | 2002 |
In vivo induction of insulin secretion by ornithine alpha-ketoglutarate: involvement of nitric oxide and glutamine.
Topics: Animals; Arginine; Blood Glucose; Enzyme Inhibitors; Glucose; Glutamate-Ammonia Ligase; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Male; Methionine Sulfoximine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Rats; Rats, Wistar | 2003 |
Glutamine and barrier function in cultured Caco-2 epithelial cell monolayers.
Topics: Caco-2 Cells; Culture Media; Glutamine; Humans; Intestinal Absorption; Methionine Sulfoximine | 2003 |
The effect of raised oxygen pressure and of methionine sulphoximine on the glutamine synthetase activity of rat brain.
Topics: Animals; Brain; Glutamate-Ammonia Ligase; Glutamine; Imines; Ligases; Methionine; Methionine Sulfoximine; Oxygen; Rats | 1963 |
THE NATURE OF THE INHIBITION IN VITRO OF CEREBRAL GLUTAMINE SYNTHETASE BY THE CONVULSANT, METHIONINE SULFOXIMINE.
Topics: Brain; Cerebral Cortex; Convulsants; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; In Vitro Techniques; Ligases; Methionine; Methionine Sulfoximine; Pharmacology; Rats; Research | 1963 |
THE EFFECT OF METHIONINE SULPHOXIMINE ON THE PROTEIN METABOLISM OF BRAIN CORTEX SLICES.
Topics: Antimetabolites; Brain; Cerebral Cortex; Glutamine; Guinea Pigs; Manometry; Methionine; Methionine Sulfoximine; Nerve Tissue Proteins; Pharmacology; Rats; Research; Sulfur Isotopes | 1963 |
FREE GLUTAMINE LEVEL IN THE RAT BRAIN IN VIVO AFTER METHIONINE SULPHOXIMINE ADMINISTRATION.
Topics: Cerebellum; Cerebral Cortex; Diencephalon; Glutamine; Mesencephalon; Methionine; Methionine Sulfoximine; Neurochemistry; Pharmacology; Rats; Research; Seizures; Succinimides; Telencephalon; Toxicology | 1964 |
EFFECT OF AN INHIBITOR OF GLUTAMINE SYNTHESIS (METHIONINE SULFOXIMINE) ON AMMONIA TOXICITY AND METABOLISM.
Topics: Ammonia; Ammonium Chloride; Brain Chemistry; Enzyme Inhibitors; Glutamine; Ligases; Metabolism; Methionine; Methionine Sulfoximine; Mice; Pharmacology; Research; Toxicology | 1964 |
THE INHIBITION IN VIVO OF CEREBRAL GLUTAMINE SYNTHETASE AND GLUTAMINE TRANSFERASE BY THE CONVULSANT METHIONINE SULFOXIMINE.
Topics: Acyltransferases; Adenosine Triphosphate; Brain; Cerebral Cortex; Chromatography; Convulsants; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Ligases; Methionine; Methionine Sulfoximine; Microsomes; Pharmacology; Rats; Research; Transaminases | 1965 |
Glutamic acid and glutamine metabolism in cerebral cortex after seizures induced by methionine sulphoximine.
Topics: Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Methionine; Methionine Sulfoximine; Seizures | 1959 |
Feedback regulation of the ammonium transporter gene family AMT1 by glutamine in rice.
Topics: Cation Transport Proteins; Feedback, Physiological; Gene Expression Regulation, Plant; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Multigene Family; Oryza; Plant Proteins; Plant Roots; Plant Shoots; Protein Isoforms; Quaternary Ammonium Compounds; RNA, Messenger | 2003 |
Methionine sulphoximine and some enzyme systems in volving glutamine.
Topics: Glutamine; Humans; Methionine; Methionine Sulfoximine | 1952 |
Effects of methionine sulfoximine on the glutamine and glutamate content and cell volume in rat cerebral cortical slices: involvement of mechanisms not related to inhibition of glutamine synthesis.
Topics: Acetates; Animals; Cell Size; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Methionine Sulfoximine; Rats; Rats, Wistar | 2004 |
Role of ammonia in reversal of glutamate-mediated Müller cell swelling in the rat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Ammonia; Animals; Cell Death; Cell Size; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Hypothermia; Methionine Sulfoximine; Neurons; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Tissue Fixation | 2004 |
Deletion of the Gibberella fujikuroi glutamine synthetase gene has significant impact on transcriptional control of primary and secondary metabolism.
Topics: Gene Expression Profiling; Gene Expression Regulation, Fungal; Genetic Complementation Test; Gibberella; Gibberellins; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Molecular Sequence Data; Nitrogen; Oligonucleotide Array Sequence Analysis; Phenotype; Quaternary Ammonium Compounds; Signal Transduction; Transformation, Genetic; Xanthones | 2004 |
Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra.
Topics: Animals; Calcium; Calcium Signaling; Citrates; Excitatory Amino Acid Agonists; Extracellular Fluid; Glutamic Acid; Glutamine; Homeostasis; Male; Membrane Potentials; Methionine Sulfoximine; Microdialysis; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substantia Nigra; Synaptic Transmission; Up-Regulation | 2005 |
Accumulation of aluminum by primary cultured astrocytes from aluminum amino acid complex and its apoptotic effect.
Topics: Aluminum Compounds; Amino Acids; Animals; Animals, Newborn; Apoptosis; Astrocytes; Cells, Cultured; Glutamates; Glutamine; Glycine; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Serine | 2005 |
Glutamine-dependent inhibition of pial arteriolar dilation to acetylcholine with and without hyperammonemia in the rat.
Topics: Acetylcholine; Ammonia; Animals; Arterioles; Blood Gas Analysis; Blood Pressure; Cerebrovascular Circulation; Endothelium, Vascular; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Intracranial Pressure; Male; Methionine Sulfoximine; Nitroprusside; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2005 |
Chronic and acute ammonia toxicity in mudskippers, Periophthalmodon schlosseri and Boleophthalmus boddaerti: brain ammonia and glutamine contents, and effects of methionine sulfoximine and MK801.
Topics: Acetates; Ammonia; Animals; Brain; Dizocilpine Maleate; Glutamate-Ammonia Ligase; Glutamine; Lethal Dose 50; Malaysia; Methionine Sulfoximine; Perciformes; Receptors, N-Methyl-D-Aspartate; Species Specificity | 2005 |
Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta).
Topics: Ammonia; Animals; Batrachoidiformes; Body Water; Brain; Glutamate-Ammonia Ligase; Glutamine; Intracranial Pressure; Magnetic Resonance Imaging; Methionine Sulfoximine; Nitrogen; Osmolar Concentration; Seawater | 2005 |
All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis.
Topics: Amino Acid Isomerases; Enzyme Inhibitors; Gene Deletion; Gene Expression Regulation, Bacterial; Gene Order; Genes, Bacterial; Genes, Essential; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Glutamine; Methionine Sulfoximine; Multigene Family; Mutagenesis, Insertional; Mycobacterium smegmatis; Mycobacterium tuberculosis; Nucleotidyltransferases; Peptide Synthases; RNA, Bacterial; RNA, Messenger; Transcription Initiation Site; Transcription, Genetic | 2005 |
Effect of AmtB homologues on the post-translational regulation of nitrogenase activity in response to ammonium and energy signals in Rhodospirillum rubrum.
Topics: Adenosine Triphosphate; ADP Ribose Transferases; Bacterial Proteins; Cation Transport Proteins; Glutamine; Methionine Sulfoximine; Nitrogenase; PII Nitrogen Regulatory Proteins; Protein Processing, Post-Translational; Quaternary Ammonium Compounds; Rhodospirillum rubrum | 2006 |
Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Astrocytes; beta-Alanine; Electric Stimulation; Enzyme Inhibitors; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Hippocampus; In Vitro Techniques; Male; Methionine Sulfoximine; Neural Inhibition; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA; Synapses | 2006 |
Stress-responsive Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation.
Topics: Carbon; Cell Nucleus; Cytoplasm; Gene Expression Regulation, Fungal; Glutamine; Methionine Sulfoximine; Models, Biological; Nitrogen; Phosphorylation; Proline; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Sodium Chloride; Transcription Factors | 2007 |
Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn.
Topics: Action Potentials; Analysis of Variance; Animals; Dental Pulp; Drug Interactions; Glutamine; Isothiocyanates; Male; Methionine Sulfoximine; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Trigeminal Caudal Nucleus | 2007 |
Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Electric Stimulation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; Glutamine; Hippocampus; Methionine Sulfoximine; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Synapses; Synaptic Transmission | 2007 |
Effect of glutamine synthesis inhibition with methionine sulfoximine on the nitric oxide-cyclic GMP pathway in the rat striatum treated acutely with ammonia: a microdialysis study.
Topics: Ammonia; Animals; Corpus Striatum; Glutamine; Guanosine Monophosphate; Male; Methionine Sulfoximine; Microdialysis; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2008 |
Exogenous ammonium inhibits petal pigmentation and expansion in Gerbera hybrida.
Topics: Anthocyanins; Asteraceae; Azaserine; Cells, Cultured; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Methionine Sulfoximine; Pigmentation; Quaternary Ammonium Compounds; Time Factors | 2008 |
Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis.
Topics: Amino Acid Sequence; Bacterial Proteins; Enzyme Inhibitors; Gene Deletion; Genes, Bacterial; Genes, Essential; Glutamate-Ammonia Ligase; Glutamine; Hot Temperature; Methionine Sulfoximine; Microbial Viability; Molecular Sequence Data; Mutant Proteins; Mycobacterium tuberculosis; Nucleotidyltransferases; Protein Structure, Tertiary; Sequence Deletion | 2008 |
In vivo monitoring of extracellular 13N-glutamine derived from blood-borne 13N-ammonia in rat striatum using microdialysis with radio-LC method.
Topics: Acetates; Ammonia; Animals; Astrocytes; Chromatography, Liquid; Citrates; Corpus Striatum; Extracellular Space; Glutamate-Ammonia Ligase; Glutamine; Male; Methionine Sulfoximine; Microdialysis; Nitrogen Radioisotopes; Radiometry; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
Glutamate metabolic pathways and retinal function.
Topics: Animals; Aspartate Aminotransferases; Electroretinography; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Homeostasis; Immunohistochemistry; Ketoglutaric Acids; Lactic Acid; Methionine Sulfoximine; Photoreceptor Cells, Vertebrate; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Succinic Acid; Synaptic Transmission; Vision, Ocular | 2009 |
[Effect of glial cell metabolism on respiratory rhythmical discharge activity in neonatal rat medulla oblongata slices].
Topics: Animals; Animals, Newborn; Glutamine; In Vitro Techniques; Medulla Oblongata; Methionine Sulfoximine; Neuroglia; Periodicity; Rats; Rats, Sprague-Dawley; Respiration | 2009 |
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Humans; Kaplan-Meier Estimate; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Mice; Mice, Transgenic; Motor Cortex; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Treatment Outcome | 2010 |
Inhibition of glutamate/glutamine cycle in vivo results in decreased benzodiazepine binding and differentially regulated GABAergic subunit expression in the rat brain.
Topics: Animals; Autoradiography; Benzodiazepines; Binding Sites; Brain; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Protein Binding; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA; RNA, Messenger; Time Factors; Tritium | 2010 |
Inhibition of glutamine synthetase during ammonia exposure in rainbow trout indicates a high reserve capacity to prevent brain ammonia toxicity.
Topics: Ammonia; Animals; Brain; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Oncorhynchus mykiss | 2010 |
Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons.
Topics: Alanine; Alanine Transaminase; Ammonia; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamine; Hyperammonemia; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Neurons | 2011 |
Cellular localization of glutamate and glutamine metabolism and transport pathways in the rat ciliary epithelium.
Topics: Animals; Aqueous Humor; Biological Transport; Carrier Proteins; Ciliary Body; Enzyme Inhibitors; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Glutamate Plasma Membrane Transport Proteins; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Immunohistochemistry; Intravitreal Injections; Methionine Sulfoximine; Microscopy, Confocal; Pigment Epithelium of Eye; Rats; Rats, Sprague-Dawley | 2011 |
The non-proteinogenic amino acids L-methionine sulfoximine and DL-phosphinothricin activate mTOR.
Topics: Aminobutyrates; Blotting, Western; Dose-Response Relationship, Drug; Glutamate-Ammonia Ligase; Glutamine; Hep G2 Cells; Humans; Methionine Sulfoximine; Phosphorylation; Stereoisomerism; TOR Serine-Threonine Kinases; Up-Regulation | 2012 |
Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine.
Topics: Antifungal Agents; Cell Nucleus; GATA Transcription Factors; Gene Expression Regulation, Fungal; Glutamine; Methionine Sulfoximine; Response Elements; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors | 2011 |
Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells.
Topics: Animals; Antibodies, Monoclonal; Batch Cell Culture Techniques; Cell Separation; Cell Survival; CHO Cells; Clone Cells; Cricetinae; Cricetulus; Diploidy; Endodeoxyribonucleases; Exons; Flow Cytometry; Gene Knockout Techniques; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Polyploidy; Recombinant Fusion Proteins; Selection, Genetic; Transfection; Zinc Fingers | 2012 |
Ammonium chloride influences in vitro-neuronal network activity.
Topics: 2-Amino-5-phosphonovalerate; Ammonium Chloride; Animals; Cerebral Cortex; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Nerve Net; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2012 |
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase.
Topics: Animals; Astrocytes; Blotting, Western; Chromatography, High Pressure Liquid; Convulsants; Electroshock; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Histamine H1 Antagonists; Histidine Decarboxylase; Immunohistochemistry; Kindling, Neurologic; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 2012 |
Indeterminate domain 10 regulates ammonium-mediated gene expression in rice roots.
Topics: Amino Acid Sequence; Gene Expression Profiling; Gene Expression Regulation, Plant; Glutamine; Methionine Sulfoximine; Molecular Sequence Data; Mutagenesis, Insertional; Nitrogen; Oryza; Phenotype; Plant Proteins; Plant Roots; Quaternary Ammonium Compounds; Sequence Alignment; Transcription Factors | 2013 |
Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.
Topics: Ammonium Compounds; Glutamine; Immunoblotting; Leucine; Methionine Sulfoximine; Monomeric GTP-Binding Proteins; Mutation; Nitrogen; Phosphorylation; Proline; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors | 2014 |
Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; beta Catenin; Cadherins; Carcinoma, Hepatocellular; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Hep G2 Cells; Humans; Ki-67 Antigen; Liver Neoplasms; Male; Methionine Sulfoximine; Mice; Mice, Nude; Mutation; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
The Molecular Basis of TnrA Control by Glutamine Synthetase in Bacillus subtilis.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Bacillus subtilis; Bacterial Proteins; Binding Sites; Binding, Competitive; Enzyme Stability; Gene Deletion; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Kinetics; Ligands; Methionine Sulfoximine; Models, Molecular; Molecular Weight; Promoter Regions, Genetic; Protein Conformation; Recombinant Proteins; Repressor Proteins; Surface Plasmon Resonance | 2016 |
Methionine sulfoximine supplementation enhances productivity in GS-CHOK1SV cell lines through glutathione biosynthesis.
Topics: Animals; Antibodies, Monoclonal; Batch Cell Culture Techniques; Buthionine Sulfoximine; Cell Culture Techniques; CHO Cells; Cricetinae; Cricetulus; Culture Media; Glutamate-Ammonia Ligase; Glutamine; Glutathione; Methionine Sulfoximine; Recombinant Proteins; Transfection | 2017 |
Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis.
Topics: Acetates; Animals; Astrocytes; Brain; Carbon Isotopes; Female; Glutamic Acid; Glutamine; Methionine Sulfoximine; Mice; Organ Culture Techniques; Substrate Specificity | 2017 |
Glutamine: a major player in nitrogen catabolite repression in the yeast Dekkera bruxellensis.
Topics: Ammonium Compounds; Catabolite Repression; Dekkera; Gene Expression Regulation, Fungal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Industrial Microbiology; Methionine Sulfoximine; Nitrates; Nitrogen; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Regulon | 2017 |
Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Movement; Endothelial Cells; Enzyme Inhibitors; Glucose; Glutamate-Ammonia Ligase; Glutamine; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Injections, Subcutaneous; Interleukin-10; Leukemia, Lymphocytic, Chronic, B-Cell; Lung Neoplasms; Macrophages; Methionine Sulfoximine; Mice; Mice, Knockout; Monocytes; Neovascularization, Pathologic; Primary Cell Culture; Succinic Acid; T-Lymphocytes, Cytotoxic | 2017 |
Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior Observation Techniques; Behavior, Animal; CA3 Region, Hippocampal; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Mice; Models, Animal; Neurogenesis; Neurons; Spatial Memory; Synaptic Transmission | 2019 |
Superfluous glutamine synthetase activity in Chinese Hamster Ovary cells selected under glutamine limitation is growth limiting in glutamine-replete conditions and can be inhibited by serine.
Topics: Animals; Carbon Isotopes; Cell Culture Techniques; CHO Cells; Cricetinae; Cricetulus; Culture Media; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Serine | 2019 |
Rapid sensing of clinically relevant glutamine concentrations in human serum with metabolically engineered E. coli-based cell-free protein synthesis.
Topics: Amino Acids; Escherichia coli; Glutamate-Ammonia Ligase; Glutamine; Humans; Methionine Sulfoximine | 2021 |
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Topics: Animals; Brain; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Pilocarpine; Rats, Sprague-Dawley; Seizures | 2021 |
Asparagine sustains cellular proliferation and c‑Myc expression in glutamine‑starved cancer cells.
Topics: Asparagine; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cysteine Proteinase Inhibitors; Gene Expression Regulation, Neoplastic; Glutamate-Ammonia Ligase; Glutamine; Humans; Leupeptins; Methionine Sulfoximine; Proteasome Endopeptidase Complex; Protein Isoforms; Proteolysis; Proto-Oncogene Proteins c-myc | 2021 |
Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose.
Topics: Animals; Brain; Disease Progression; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Lithium; Male; Methionine Sulfoximine; Pilocarpine; Rats; Rats, Sprague-Dawley; Secretory Pathway; Seizures | 2021 |
Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Glutamate-Ammonia Ligase; Glutamine; Immunoglobulin G; Lactic Acid; Methionine Sulfoximine | 2022 |
Glutamine synthetase plays an important role in ammonium tolerance of Myriophyllum aquaticum.
Topics: Ammonium Compounds; Animals; Asparagine; Glutamate-Ammonia Ligase; Glutamine; Methionine Sulfoximine; Nitrogen; Saxifragales; Swine; Wastewater | 2022 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |