Page last updated: 2024-08-17

methionine and sirolimus

methionine has been researched along with sirolimus in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (15.38)18.2507
2000's12 (30.77)29.6817
2010's15 (38.46)24.3611
2020's6 (15.38)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Jefferies, HB; Kozma, SC; Reinhard, C; Thomas, G1
Morley, SJ; Pain, VM1
Cheng, YR; Demain, AL; Fang, A1
Castellucci, VF; Hislop, J; Manseau, F; Sossin, WS; Yanow, SK1
Bragado, MJ; Groblewski, GE; Williams, JA1
Gnudi, L; Kahn, BB; Law, BK; Moses, HL; Nørgaard, P; Poulson, HS1
Proud, CG; Wang, L; Wang, X1
Law, BK; Moses, HL; Norgaard, P1
Demain, AL; Fang, A; Kim, WS; Wang, Y1
Beale, G; Cross, J; England, K; Rumsby, M; Warner, M; Watson, J1
Hara, K; Kawamura, M; Nawa, H; Takei, N; Yonezawa, K1
Hazlerigg, DG; Lomax, MA; Stubbs, AK; Wheelhouse, NM1
Hara, K; Hidayat, S; Matsuo, M; Tokunaga, C; Yonezawa, K; Yoshino, K1
de las Heras, M; Fan, H; Fu, W; Maeda, N; Ortin, A1
Buford, TD; Cooper, TG; Kulkarni, A; Rai, R1
Kennedy, S; Wadsworth, RM; Wainwright, CL1
Chen, QM; Purdom-Dickinson, SE; Sheveleva, EV; Sun, H1
Al-Younes, H; Braun, PR; Gussmann, J; Klein, J; Meyer, TF; Schneider, E1
Collins, JJ; Ferree, A; Guillily, M; Li, H; Smith, K; Squillace, R; Takashima, A; Weigele, M; Wolozin, B1
Beugnet, A; Biffo, S; Brina, D; Grosso, S; Loreni, F; Pesce, E1
Agostini, M; Antonov, A; Garabadgiu, AV; Melino, G; Porta, G; Tucci, P; Willis, AE1
Arriola Apelo, SI; Hanigan, MD; Lin, XY; McGilliard, ML; Singer, LM; St-Pierre, NR1
Gao, X; Huang, Y; Li, Q; Luo, C; Si, Y; Yu, C; Zhang, N; Zhang, X; Zhao, F1
Giallongo, F; Hristov, AN; Lang, CH; Parys, C; Sadri, H; Saremi, B; Sauerwein, H; Werner, J1
Nacarelli, T; Sell, C1
Gladyshev, VN; Ma, S1
Azar, A; Jofre, S; Lawrence, I; Mell, J; Sell, C1
Dong, X; Helmbrecht, A; Loor, JJ; Saremi, B; Wang, L; Wang, Z; Zhou, Z1
Alharthi, ASM; Batistel, F; Helmbrecht, A; Loor, JJ; Parys, C; Shen, X; Trevisi, E; Xu, T1
Heinemann, M; Hsu, CH; Kato, M; Lemoff, A; Litsios, A; Mirzaei, H; Sutter, BM; Tu, BP; Wang, Y; Wood, NE; Wu, X; Yang, YS1
Chi, S; Dong, X; Han, F; He, Y; Liu, D; Liu, H; Tan, B; Yang, Q; Zhang, S1
Barré, BP; Hallin, J; Holt, S; Irizar, A; Liti, G; Mikhalev, E; Molin, M; Persson, K; Thompson, D; Warringer, J; Yue, JX1
Azar, A; Brown-Borg, H; Johannes, G; Johnson, FB; Mell, J; Nacarelli, T; Noguchi, E; Potnis, M; Sell, C1
Chen, YK; Guo, ZX; Lei, XY; Liu, HJ; Wan, JW; Wang, GQ; Wang, QJ; Wang, S; Wang, X; Zhang, DM1
Aoki, Y; Bouvet, M; Han, Q; Hoffman, RM; Hozumi, C; Kubota, Y; Masaki, N; Obara, K; Samonte, C; Wu, J; Wu, NF1
Duan, X; Gong, X; Hou, X; Jiao, H; Lin, Y; Liu, C; Yang, Y1

Reviews

3 review(s) available for methionine and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Targeting metabolism in cellular senescence, a role for intervention.
    Molecular and cellular endocrinology, 2017, Nov-05, Volume: 455

    Topics: Aging; Animals; Cell Cycle Proteins; Cellular Senescence; Cytokines; Electron Transport Chain Complex Proteins; Gene Expression Regulation; Glucose; Humans; Mechanistic Target of Rapamycin Complex 1; Methionine; Mitochondria; Phenotype; Signal Transduction; Sirolimus

2017
Molecular signatures of longevity: Insights from cross-species comparative studies.
    Seminars in cell & developmental biology, 2017, Volume: 70

    Topics: Animals; Bowhead Whale; Caloric Restriction; Chiroptera; Gene Expression Regulation, Developmental; Genome; Humans; Insulin-Like Growth Factor I; Killifishes; Longevity; Metabolome; Metformin; Methionine; Mole Rats; Sirolimus; TOR Serine-Threonine Kinases; Transcriptome

2017

Trials

1 trial(s) available for methionine and sirolimus

ArticleYear
Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model.
    Anticancer research, 2022, Volume: 42, Issue:11

    Topics: Animals; Bone Neoplasms; Carbon-Sulfur Lyases; Disease Models, Animal; Heterografts; Methionine; Mice; Mice, Nude; Osteosarcoma; Recombinant Proteins; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2022

Other Studies

35 other study(ies) available for methionine and sirolimus

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, May-10, Volume: 91, Issue:10

    Topics: 3T3 Cells; Actins; Animals; Immunosuppressive Agents; Methionine; Mice; Molecular Sequence Data; Oligonucleotide Probes; Peptide Elongation Factor 1; Peptide Elongation Factors; Phosphorylation; Polyenes; Polyribosomes; Protein Biosynthesis; Pyrimidines; Ribosomal Protein S6; Ribosomal Proteins; RNA, Messenger; Sirolimus; Transcription, Genetic

1994
Translational regulation during activation of porcine peripheral blood lymphocytes: association and phosphorylation of the alpha and gamma subunits of the initiation factor complex eIF-4F.
    The Biochemical journal, 1995, Dec-01, Volume: 312 ( Pt 2)

    Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Concanavalin A; Eukaryotic Initiation Factor-4F; Gene Expression Regulation; Immune Sera; Immunoblotting; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Lymphocytes; Macromolecular Substances; Methionine; Molecular Sequence Data; Peptide Initiation Factors; Peptides; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Polyenes; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Sulfur Radioisotopes; Swine; Tetradecanoylphorbol Acetate

1995
Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus.
    Applied microbiology and biotechnology, 1995, Volume: 43, Issue:6

    Topics: Amino Acids; Antifungal Agents; Culture Media; Lysine; Methionine; Phenylalanine; Pipecolic Acids; Polyenes; Quaternary Ammonium Compounds; Sirolimus; Streptomyces

1995
Biochemical pathways by which serotonin regulates translation in the nervous system of Aplysia.
    Journal of neurochemistry, 1998, Volume: 70, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aplysia; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ganglia, Invertebrate; Gene Expression Regulation; In Vitro Techniques; Kinetics; Methionine; Neuronal Plasticity; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Polyenes; Protein Biosynthesis; Protein Kinase C; Protein-Tyrosine Kinases; Serotonin; Sirolimus; Synapses; Time Factors

1998
Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway.
    Gastroenterology, 1998, Volume: 115, Issue:3

    Topics: Androstadienes; Animals; Bombesin; Carbachol; Carrier Proteins; Cholecystokinin; Chromones; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Kinetics; Male; Methionine; Morpholines; Pancreas; Peptide Initiation Factors; Phosphoproteins; Polyenes; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Wortmannin

1998
Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
    The Journal of biological chemistry, 1999, Feb-19, Volume: 274, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Alkyl and Aryl Transferases; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cell Line; DNA Replication; Enzyme Inhibitors; Eukaryotic Initiation Factors; Farnesyltranstransferase; Keratinocytes; Methionine; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphoproteins; Phosphorylation; ras Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tumor Cells, Cultured

1999
Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:4

    Topics: Age Factors; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Heart Ventricles; Hypoglycemic Agents; Immunosuppressive Agents; Insulin; Intracellular Signaling Peptides and Proteins; Methionine; Morpholines; Muscle Fibers, Skeletal; Myocardium; Peptide Elongation Factor 2; Peptide Initiation Factors; Phenylalanine; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Sulfur Radioisotopes; Tritium

2000
Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.
    The Journal of biological chemistry, 2000, Apr-14, Volume: 275, Issue:15

    Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Keratinocytes; Marine Toxins; Methionine; Mice; Oxazoles; Phosphorylation; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate

2000
Methionine interference in rapamycin production involves repression of demethylrapamycin methyltransferase and S-adenosylmethionine synthetase.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:10

    Topics: Chromatography, High Pressure Liquid; Fermentation; Magnesium; Methionine; Methionine Adenosyltransferase; Methyltransferases; Sirolimus; Streptomyces

2000
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection

2001
Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin.
    The Journal of biological chemistry, 2001, Nov-16, Volume: 276, Issue:46

    Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Brain; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Insulin; MAP Kinase Signaling System; Methionine; Morpholines; Neurons; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Biosynthesis; Rats; Signal Transduction; Sirolimus; Time Factors; Up-Regulation

2001
Nutrient-hormone interaction in the ovine liver: methionine supply selectively modulates growth hormone-induced IGF-I gene expression.
    The Journal of endocrinology, 2002, Volume: 174, Issue:2

    Topics: Analysis of Variance; Animals; Cells, Cultured; Enzyme Inhibitors; Gene Expression Regulation; Growth Hormone; Hepatocytes; Insulin-Like Growth Factor I; Methionine; Phosphorylation; Ribosomal Protein S6 Kinases; Sheep; Sirolimus

2002
Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.
    Biochemical and biophysical research communications, 2003, Feb-07, Volume: 301, Issue:2

    Topics: Alanine; Animals; Antibiotics, Antineoplastic; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase; Humans; Jurkat Cells; Leucine; Methionine; Phosphorylation; Protein Kinases; Retinoblastoma Protein; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins

2003
Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines.
    Journal of virology, 2005, Volume: 79, Issue:7

    Topics: Animals; Butadienes; Cell Transformation, Viral; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Flavonoids; Jaagsiekte sheep retrovirus; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Methionine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2005
Differing responses of Gat1 and Gln3 phosphorylation and localization to rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae.
    FEMS yeast research, 2006, Volume: 6, Issue:2

    Topics: Antifungal Agents; Carbon; Cell Nucleus; Culture Media; Cytoplasm; GATA Transcription Factors; Methionine; Nitrogen; Phosphorylation; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors; Zinc Fingers

2006
Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery.
    Vascular pharmacology, 2006, Volume: 44, Issue:5

    Topics: Angioplasty, Balloon, Coronary; Animals; Azulenes; Calcimycin; Coronary Vessels; Fucose; Growth Inhibitors; Male; Methionine; Models, Animal; Serotonin; Sirolimus; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2006
Translational control of nrf2 protein in activation of antioxidant response by oxidants.
    Molecular pharmacology, 2007, Volume: 72, Issue:4

    Topics: Animals; Antioxidants; Cells, Cultured; Dactinomycin; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4E; Hydrogen Peroxide; Methionine; NF-E2-Related Factor 2; Oxidants; Phosphorylation; Protein Biosynthesis; Rats; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Sirolimus

2007
Competitive inhibition of amino acid uptake suppresses chlamydial growth: involvement of the chlamydial amino acid transporter BrnQ.
    Journal of bacteriology, 2008, Volume: 190, Issue:5

    Topics: Amino Acid Transport Systems; Amino Acids; Bacterial Proteins; Biological Transport; Cell Survival; Chlamydia; Chromatography, High Pressure Liquid; Cycloheximide; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Bacterial; Genetic Complementation Test; Glycine; HeLa Cells; Humans; Isoleucine; Leucine; Methionine; Microscopy, Confocal; Microscopy, Electron, Transmission; Oligonucleotide Array Sequence Analysis; Phenylalanine; Reverse Transcriptase Polymerase Chain Reaction; Serine; Sirolimus; Threonine

2008
Regulation of physiologic actions of LRRK2: focus on autophagy.
    Neuro-degenerative diseases, 2012, Volume: 10, Issue:1-4

    Topics: Animals; Animals, Genetically Modified; Autophagy; Caenorhabditis elegans; Disease Models, Animal; Gene Expression Regulation; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Methionine; Mutation; Parkinson Disease; Protein Serine-Threonine Kinases; Sirolimus; tau Proteins; Valine

2012
Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Cell Cycle Proteins; Cell Line, Tumor; Eukaryotic Initiation Factor-4E; Humans; Methionine; Phosphoproteins; Phosphorylation; Protein Binding; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases; Transcription, Genetic

2011
Rapamycin regulates biochemical metabolites.
    Cell cycle (Georgetown, Tex.), 2013, Aug-01, Volume: 12, Issue:15

    Topics: Animals; Biosynthetic Pathways; Cells, Cultured; Glutathione; Glycolysis; Metabolome; Methionine; Mice; Mice, Knockout; Nuclear Proteins; Pentose Phosphate Pathway; Sirolimus

2013
Isoleucine, leucine, methionine, and threonine effects on mammalian target of rapamycin signaling in mammary tissue.
    Journal of dairy science, 2014, Volume: 97, Issue:2

    Topics: Animals; Cattle; Epithelial Cells; Female; Isoleucine; Lactation; Leucine; Mammary Glands, Animal; Methionine; Milk; Milk Proteins; Phosphorylation; Protein Biosynthesis; Proteins; Ribosomal Protein S6; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases

2014
GSK3β regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway.
    Molecules (Basel, Switzerland), 2014, Jul-03, Volume: 19, Issue:7

    Topics: Animals; Cattle; Cell Proliferation; Cells, Cultured; Epithelial Cells; Female; Glycogen Synthase Kinase 3; Lactation; Lithium Chloride; Mammary Glands, Animal; Methionine; Phosphorylation; Protein Processing, Post-Translational; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2014
Effects of slow-release urea and rumen-protected methionine and histidine on mammalian target of rapamycin (mTOR) signaling and ubiquitin proteasome-related gene expression in skeletal muscle of dairy cows.
    Journal of dairy science, 2016, Volume: 99, Issue:8

    Topics: Animal Nutritional Physiological Phenomena; Animals; Cattle; Diet; Dietary Proteins; Female; Gene Expression Regulation; Histidine; Lactation; Methionine; Milk; Muscle, Skeletal; Proteasome Endopeptidase Complex; Rumen; Sirolimus; Ubiquitin; Urea

2016
Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction.
    Annals of the New York Academy of Sciences, 2018, Volume: 1418, Issue:1

    Topics: Biomarkers; Cellular Senescence; Fibroblasts; Gene Expression; Humans; Methionine; Myocardium; Principal Component Analysis; Reproducibility of Results; Sirolimus

2018
Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription.
    Journal of dairy science, 2018, Volume: 101, Issue:6

    Topics: Amino Acid Sequence; Animals; Cattle; Female; Isoleucine; Leucine; Lysine; Mammary Glands, Animal; Methionine; Peptide Fragments; Sirolimus; Threonine; Transcription, Genetic; Valine

2018
Hepatic phosphorylation status of serine/threonine kinase 1, mammalian target of rapamycin signaling proteins, and growth rate in Holstein heifer calves in response to maternal supply of methionine.
    Journal of dairy science, 2018, Volume: 101, Issue:9

    Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Cattle; Diet; Female; Methionine; Phosphorylation; Pregnancy; Protein Serine-Threonine Kinases; Serine; Sirolimus

2018
Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth.
    Cell, 2019, 04-18, Volume: 177, Issue:3

    Topics: Amino Acid Sequence; Autophagy; Carrier Proteins; Mechanistic Target of Rapamycin Complex 1; Methionine; Mitochondria; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Domains; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus

2019
dl-Methionine supplementation in a low-fishmeal diet affects the TOR/S6K pathway by stimulating ASCT2 amino acid transporter and insulin-like growth factor-I in the dorsal muscle of juvenile cobia (
    The British journal of nutrition, 2019, 10-14, Volume: 122, Issue:7

    Topics: Amino Acid Transport System ASC; Animal Feed; Animals; Blood Glucose; Fish Products; Fishes; Gene Expression; Insulin; Insulin-Like Growth Factor I; Liver; Methionine; Muscles; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2019
Intragenic repeat expansion in the cell wall protein gene
    Genome research, 2020, Volume: 30, Issue:5

    Topics: Cell Wall; DNA Repeat Expansion; Genes, Fungal; Lipid Metabolism; Membrane Glycoproteins; Methionine; Purines; Quantitative Trait Loci; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus

2020
The methyltransferase enzymes KMT2D, SETD1B, and ASH1L are key mediators of both metabolic and epigenetic changes during cellular senescence.
    Molecular biology of the cell, 2022, 05-01, Volume: 33, Issue:5

    Topics: Cellular Senescence; Epigenesis, Genetic; Fibroblasts; Glycolysis; Methionine; Sirolimus

2022
The immuneoreaction and antioxidant status of Chinese mitten crab (Eriocheir sinensis) involve protein metabolism and the response of mTOR signaling pathway to dietary methionine levels.
    Fish & shellfish immunology, 2022, Volume: 127

    Topics: Animal Feed; Animals; Antioxidants; Brachyura; China; Diet; Dietary Supplements; Immunity, Innate; Mammals; Methionine; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2022
mTORC2-AKT-LAT1 signalling participates in methionine-induced β-CASEIN expression in mammary epithelial cells of dairy cows.
    Journal of animal physiology and animal nutrition, 2023, Volume: 107, Issue:6

    Topics: Animals; Caseins; Cattle; Epithelial Cells; Female; Lactation; Mammals; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Methionine; Milk Proteins; Proto-Oncogene Proteins c-akt; Racemethionine; RNA, Small Interfering; Sirolimus; Transcription Factors

2023