methionine has been researched along with mevalonic acid in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (50.00) | 18.7374 |
| 1990's | 15 (26.79) | 18.2507 |
| 2000's | 10 (17.86) | 29.6817 |
| 2010's | 3 (5.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beck, SD; Griffiths, GW; Houk, EJ | 1 |
| Nambudiri, AM; Ranganathan, S; Rudney, H | 1 |
| Blomquist, GJ; Lok, JB; Major, MA | 1 |
| Caron, MG; Glickman, JF; Inglese, J; Lefkowitz, RJ; Lorenz, W | 1 |
| Cadwallader, K; Hancock, JF; Marshall, CJ | 1 |
| Jones, TL; Spiegel, AM | 1 |
| Beck, L; Leonard, S; Sinensky, M | 1 |
| Beck, LA; Hosick, TJ; Sinensky, M | 1 |
| Buddecke, E; Filipovic, I | 2 |
| Cooper, AD; Ellsworth, JL; Erickson, SK | 1 |
| Glomset, JA; Wolda, SL | 1 |
| Aiyar, AS; Olson, RE | 1 |
| De Rosa, M; Minale, L; Sodano, G | 1 |
| Dahm, KH; Metzler, M; Meyer D Röller, H | 1 |
| Aiyar, AS; Olson, RE; Opliger, CE; Trumpower, BL | 1 |
| Bassett, RA; Chain, EB; Corbett, K | 1 |
| Dialameh, GH; Nowicki, HG; Olson, RE | 1 |
| Aiyar, AS; Gopalaswamy, UV; Sreenivasan, A | 1 |
| Bezanson, GS; Vining, LC | 1 |
| Schütte, HR; Seelig, G | 1 |
| Malhotra, HC; Nes, WR | 1 |
| Lederer, E; Polonsky, J; Zissmann, E; Zylber, J | 1 |
| Cooney, JJ; Thierry, OC | 1 |
| Raman, TS; Rudney, H | 1 |
| Goad, LJ; Goodwin, TW | 1 |
| el-Basyouni, SH; Vining, LC | 1 |
| Bloch, K; Katsuki, H | 1 |
| Birch, AJ | 1 |
| Appel, HH; Auda, H; Eisenbraun, EJ; Juneja, HR; Kays, WR; Waller, GR | 1 |
| Blondin, GA; Castle, M; Nes, WR | 1 |
| Jeng, I; Klemm, N; Proctor, B | 1 |
| Cox, AD | 1 |
| Dalton, M; Sinensky, M | 1 |
| de Bony, J; Magee, AI; Wootton, J | 1 |
| Firmbach-Kraft, I; Stick, R | 1 |
| Li, G; Stahl, PD | 1 |
| Farrell, FX; Lapetina, EG; Yamamoto, K | 1 |
| Buss, JE; Cox, AD; Der, CJ; Graham, SM; Solski, PA | 1 |
| Armstrong, J; Giannakouros, T; Magee, AI; Newman, CM | 1 |
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 1 |
| Bellavia, S; Cartwright, IJ; Graham, JM; Higgins, JA; Kendrick, JS; Wilkinson, J | 1 |
| Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z | 1 |
| Hohl, RJ; Holstein, SA; Wohlford-Lenane, CL | 1 |
| Chait, A; Meyers, CD; Tannock, LR; Wight, TN | 1 |
| ADYE, J; MATELES, RI | 1 |
| Inoue, M; Kusama, T; Matsumoto, Y; Mukai, M; Nakamura, H; Tatsuta, M | 1 |
| Favre, G; Leveque, K; Sarrabayrouse, G; Synaeve, C; Tilkin-Mariamé, AF | 1 |
| Magee, AI | 1 |
| Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I | 1 |
| Albrecht, G; Gabriel, D; Heidinger, V; Hofmann, G; Ibig-Rehm, Y; Magnier, M; Simonen, M; Zimmermann, J | 1 |
| Burne-Taney, MJ; Ikeda, M; Ito, K; Kumagai, K; Mori, M; Rabb, H; Sharyo, S; Uchida, K; Yokota-Ikeda, N | 1 |
| Horiuchi, N; Maeda, T | 1 |
| Jefferson, LS; Jefferson, SJ; Kimball, SR; Tuckow, AP | 1 |
| Chakir, J; Ghavami, S; Halayko, AJ; Jacques, E; Laviolette, M; McNeill, KD; Mutawe, MM; Schaafsma, D; Unruh, H | 1 |
| Aimi, T; Boonlue, S; Ichiyanagi, T; Nakajima, H; Srisapoomi, T | 1 |
56 other study(ies) available for methionine and mevalonic acid
| Article | Year |
|---|---|
Lipid metabolism in the symbiotes of the pea aphid, Acyrthosiphon pisum.
Topics: Acetates; Adenosine Triphosphate; Animals; Aphids; Choline; Lipid Metabolism; Methionine; Mevalonic Acid; NADP; Phospholipids; Plants; Rickettsiaceae; Serine; Sterols | 1976 |
The biosynthesis of ubiquinone in isolated rat heart cells.
Topics: Animals; Dimethyl Sulfoxide; Doxorubicin; Hydroxybenzoates; In Vitro Techniques; Methionine; Mevalonic Acid; Myocardium; Rats; Ubiquinone | 1979 |
Biosynthesis of 3-methylpentacosane in the cockroach Periplaneta americana.
Topics: Acetates; Alkanes; Animals; Carbon Radioisotopes; Chromatography, Gas; Cockroaches; Isoleucine; Lactones; Methionine; Methylmalonic Acid; Mevalonic Acid; Propionates; Tritium; Valine | 1975 |
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cattle; Cell Line; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; Glutathione Transferase; Kinetics; Methionine; Methylation; Mevalonic Acid; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Protein Kinases; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Rod Cell Outer Segment; Transfection | 1992 |
Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).
Topics: Animals; Cell Line; Cell Membrane; Dogs; Esters; Kinetics; Methionine; Methylation; Mevalonic Acid; Microsomes; Mutagenesis, Site-Directed; Pancreas; Protein Binding; Protein Biosynthesis; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Rabbits; Reticulocytes; RNA, Messenger | 1991 |
Isoprenylation of an inhibitory G protein alpha subunit occurs only upon mutagenesis of the carboxyl terminus.
Topics: Adenosine Diphosphate Ribose; Animals; Base Sequence; Cell Line; Gene Expression; GTP-Binding Proteins; Immunoblotting; Immunosorbent Techniques; Methionine; Mevalonic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Pertussis Toxin; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; Rats; Transfection; Virulence Factors, Bordetella | 1990 |
Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.
Topics: Animals; Cell Line; Cholesterol; Genes, ras; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Methionine; Mevalonic Acid; Oncogene Protein p21(ras); Protein Precursors; Protein Processing, Post-Translational; Transfection | 1990 |
Isoprenylation is required for the processing of the lamin A precursor.
Topics: Amino Acid Sequence; Animals; Carbon Radioisotopes; Cell Nucleus; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Humans; Intermediate Filaments; Kinetics; Lamin Type A; Lamin Type B; Lamins; Methionine; Mevalonic Acid; Molecular Sequence Data; Nuclear Proteins; Precipitin Tests; Protein Precursors; Protein Processing, Post-Translational; Sulfur Radioisotopes | 1990 |
Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Acetates; Acetic Acid; Androstenes; Calcium Chloride; Calmodulin; Cholera Toxin; Cholesterol; Cyclic AMP; Fibroblasts; Humans; Hydroxycholesterols; Lovastatin; Methionine; Mevalonic Acid; Molecular Weight; Naphthalenes; p-Methoxy-N-methylphenethylamine; Receptors, LDL; Skin; Sulfonamides; Trifluoperazine | 1986 |
Glucocorticoid-stimulated biosynthesis of low density lipoprotein receptor in cultured fibroblasts.
Topics: Acetates; Cathepsin D; Cells, Cultured; Cholesterol; Dexamethasone; Fibroblasts; Humans; Lipoproteins, LDL; Methionine; Mevalonic Acid; Receptors, Cell Surface; Receptors, Lipoprotein; Skin; Time Factors | 1985 |
Very low and low density lipoprotein synthesis and secretion by the human hepatoma cell line Hep-G2: effects of free fatty acid.
Topics: Acetates; Apolipoproteins B; Carcinoma, Hepatocellular; Cell Line; Humans; Kinetics; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Liver Neoplasms; Methionine; Mevalonic Acid; Oleic Acid; Oleic Acids; Phospholipids; Serum Albumin, Bovine; Triglycerides | 1986 |
Evidence for modification of lamin B by a product of mevalonic acid.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; HeLa Cells; Humans; Isoelectric Focusing; Lamin Type B; Lamins; Methionine; Mevalonic Acid; Mice; Nuclear Proteins | 1988 |
Enhancement of ubiquinone-9 biosynthesis in rat-liver slices by exogenous mevalonate.
Topics: Alkenes; Animals; Benzoates; Carbon Isotopes; Cholesterol; Dietary Fats; Fasting; Female; In Vitro Techniques; Liver; Methionine; Mevalonic Acid; Phosphoric Acids; Rats; Ubiquinone; Vanadium | 1972 |
Metabolism in porifera. I. Some studies on the biosynthesis of fatty acids, sterols and bromo-compounds by the sponge Verongia aerophoba.
Topics: Acetates; Animals; Bromine; Carbon Isotopes; Chromatography; Chromatography, Gas; Fatty Acids; Freeze Drying; Methionine; Mevalonic Acid; Ornithine; Porifera; Seawater; Silicon Dioxide; Sterols; Tyrosine | 1973 |
On the biosynthesis of juvenile hormone in the adult Cecropia moth.
Topics: Acetates; Biological Evolution; Carbon Isotopes; Farnesol; Insecta; Juvenile Hormones; Methionine; Methylation; Mevalonic Acid; Propionates; Time Factors; Tritium | 1971 |
Studies on ubiquinone. The isolation and identification of 5-demethoxyubiquinone-9 as an intermediate in biosynthesis of ubiquinone-9 in the rat.
Topics: Aluminum; Animals; Benzoates; Carbon Isotopes; Chromatography; Chromatography, Gel; Chromatography, Thin Layer; Isotope Labeling; Kinetics; Liver; Male; Mass Spectrometry; Methionine; Mevalonic Acid; Perfusion; Phenols; Rats; Saccharomyces cerevisiae; Spectrophotometry; Tritium; Ubiquinone; Ultraviolet Rays | 1972 |
Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul.
Topics: Acetates; Alanine; Amino Acids; Carbon Isotopes; Cells, Cultured; Chromatography, Ion Exchange; Chromatography, Thin Layer; Culture Media; Electrophoresis, Paper; Ergotamine; Formates; Hydrogen-Ion Concentration; Isomerism; Methionine; Mevalonic Acid; Phenylalanine; Plants; Proline; Spectrophotometry, Ultraviolet; Tryptophan | 1973 |
Isolation and identification of 6-methoxy-2-nonaprenylphenol as an intermediate in the biosynthesis of ubiquinone-9 in the rat.
Topics: Animals; Benzoates; Carbon Isotopes; Chromatography; Chromatography, Thin Layer; Crystallization; Ethers; Lipids; Liver; Male; Mass Spectrometry; Methionine; Mevalonic Acid; Models, Chemical; Phenols; Rats; Spectrophotometry; Terpenes; Tritium; Ubiquinone; Ultraviolet Rays | 1972 |
Biogenesis of ubiquinone in rats--an alternate origin of the benzoquinone moiety.
Topics: Animals; Benzoates; Carbon Isotopes; Cholesterol; Cyclohexanecarboxylic Acids; Depression, Chemical; Female; In Vitro Techniques; Liver; Methionine; Mevalonic Acid; Quinic Acid; Quinones; Rats; Shikimic Acid; Tyrosine; Ubiquinone | 1971 |
Studies on the biosynthesis of mitomycin C by Streptomyces verticillatus.
Topics: Acetamides; Acetates; Alanine; Anhydrides; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Chromatography, Thin Layer; Formates; Glucose; Glycine; Heptoses; Isoleucine; Leucine; Methionine; Mevalonic Acid; Mitomycins; Models, Biological; Models, Structural; Oxidation-Reduction; Pentosephosphates; Phenylalanine; Serine; Shikimic Acid; Sodium; Spectrophotometry; Streptomyces; Tryptophan; Valine | 1971 |
[On the biosynthesis of pilocereine and lophocerine].
Topics: Carbon Isotopes; Isoquinolines; Leucine; Methionine; Mevalonic Acid; Plants; Tyrosine | 1969 |
The mechanism of introduction of alkyl groups at C-24 of sterols. IV. Inhibition by triparanol.
Topics: Alcohols; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Cholestanes; Chromatography, Thin Layer; Cyclosteroids; Metabolism; Methionine; Methylation; Mevalonic Acid; Models, Biological; Plants; Protein Binding; Squalene; Sterols; Triparanol | 1971 |
[On the biosynthesis of the piloquinone, o-phenanthrene-quinone produced by Streptomyces pilosus].
Topics: Acetates; Alcohols; Butyrates; Caproates; Carbon Isotopes; Coenzyme A; Methionine; Mevalonic Acid; Oxidation-Reduction; Phenanthrenes; Pigments, Biological; Propionates; Quinones; Streptomyces; Valine | 1969 |
A defined medium for growth and pigment synthesis of Micrococcus roseus.
Topics: Adenine; Amines; Arginine; Culture Media; Fructose; Glutamates; Glycine; Isoleucine; Leucine; Lutein; Methionine; Mevalonic Acid; Micrococcus; Pigments, Biological; Proline; Salts; Serine; Spectrophotometry | 1966 |
Synthesis and interrelatonship of ubiquinone and ubichromenol in rat tissues.
Topics: Animals; Benzoates; Benzopyrans; Carbon Isotopes; Chromatography; In Vitro Techniques; Kidney; Methionine; Mevalonic Acid; Rats; Spectrophotometry; Ubiquinone | 1966 |
The biosynthesis of sterols in higher plants.
Topics: Carbon Isotopes; Chromatography; Chromatography, Gas; Chromatography, Thin Layer; Methionine; Mevalonic Acid; Plants; Sterols | 1966 |
Biosynthesis of oosporein in Beauveria bassiana (Bals.) Vuill.
Topics: Acetates; Carbon Isotopes; Chemical Phenomena; Chemistry; Culture Media; Formates; Malonates; Methionine; Mevalonic Acid; Mitosporic Fungi; Oxidation-Reduction; Pigments, Biological; Quinones; Resorcinols; Shikimic Acid | 1966 |
Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates.
Topics: Alkylation; Chromatography, Gas; Chromatography, Paper; Methionine; Mevalonic Acid; Nucleosides; Saccharomyces; Squalene; Sterols; Vitamin D | 1967 |
Biosynthesis of polyketides and related compounds.
Topics: Acetates; Alkylation; Benzoates; Chemistry, Organic; Coenzyme A; Flavonoids; Methionine; Mevalonic Acid; Organic Chemistry Phenomena; Penicillium; Salicylates; Terpenes | 1967 |
Biosynthesis of methylcyclopentane monoterpenoids. I. Skytanthus alkaloids.
Topics: Alkaloids; Carbon Isotopes; Chromatography, Gas; Cyclopentanes; Methionine; Mevalonic Acid; Plants, Medicinal; Terpenes | 1967 |
The mechanism of introduction of alkyl groups at C-24 of sterols. I. The precursor of the C2 group.
Topics: Carbon Isotopes; Chromatography, Gas; Eukaryota; Methionine; Methylation; Mevalonic Acid; Plants, Edible; Sterols; Terpenes | 1967 |
Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A.
Topics: Androstenes; Animals; Anticholesteremic Agents; Cell Line; Glioma; Hydroxybenzoates; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Methionine; Mevalonic Acid; Naphthalenes; Parabens; Rats; Tyrosine; Ubiquinone | 1984 |
Mutation and analysis of prenylation signal sequences.
Topics: Animals; Cells, Cultured; Cloning, Molecular; Cysteine; DNA Mutational Analysis; Indicators and Reagents; Mammals; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Polymerase Chain Reaction; Protein Biosynthesis; Protein Prenylation; Protein Sorting Signals; Rabbits; Radioisotope Dilution Technique; Recombinant Proteins; Reticulocytes; Sesquiterpenes; Sulfur Radioisotopes; Tritium | 1995 |
Expression systems for nuclear lamin proteins: farnesylation in assembly of nuclear lamina.
Topics: Animals; Autoradiography; Cell Nucleus; CHO Cells; Cloning, Molecular; Cricetinae; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Humans; Immunoblotting; Lamins; Methionine; Mevalonic Acid; Nuclear Matrix; Nuclear Proteins; Protein Prenylation; Protein Processing, Post-Translational; Radioisotope Dilution Technique; Recombinant Proteins; Restriction Mapping; Saccharomyces cerevisiae; Schizosaccharomyces; Sulfur Radioisotopes; Transfection; Tritium; Vertebrates | 1995 |
Detecting radiolabeled lipid-modified proteins in polyacrylamide gels.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Cell Line; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Nonesterified; Hybrid Cells; Indicators and Reagents; Isotope Labeling; Methionine; Mevalonic Acid; Myristic Acid; Myristic Acids; Palmitic Acid; Palmitic Acids; Protein Processing, Post-Translational; Proteins; Radioisotope Dilution Technique; Tritium | 1995 |
The role of CaaX-dependent modifications in membrane association of Xenopus nuclear lamin B3 during meiosis and the fate of B3 in transfected mitotic cells.
Topics: Amino Acid Sequence; Animals; Cell Cycle; Cell Nucleus; DNA, Complementary; Female; Intermediate Filament Proteins; L Cells; Lamin Type B; Meiosis; Methionine; Methylation; Mevalonic Acid; Mice; Mitosis; Molecular Sequence Data; Nuclear Envelope; Nuclear Proteins; Oocytes; Transfection; Xenopus laevis | 1993 |
Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5).
Topics: Animals; Biological Transport; Cell Compartmentation; Cells, Cultured; Chick Embryo; Cytosol; Fibroblasts; GTP-Binding Proteins; Membranes; Methionine; Methylation; Mevalonic Acid; Protein Prenylation; Protein Processing, Post-Translational; rab4 GTP-Binding Proteins; rab5 GTP-Binding Proteins; Recombinant Proteins; Sindbis Virus | 1993 |
Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Genes, ras; GTP-Binding Proteins; Humans; Methionine; Mevalonic Acid; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Protein Biosynthesis; Proto-Oncogene Proteins; Rabbits; rap GTP-Binding Proteins; Reticulocytes; Sequence Homology, Amino Acid; Transcription, Genetic; Transfection | 1993 |
The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cysteine; Genes, ras; GTP-Binding Proteins; Methionine; Mevalonic Acid; Mice; Molecular Sequence Data; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rab5 GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Transfection; Tritium | 1993 |
Processing of the small GTP-binding protein SpYPT1p in Schizosaccharomyces pombe and in mammalian COS cells.
Topics: Animals; Cell Line; Cloning, Molecular; Fungal Proteins; Kinetics; Methionine; Mevalonic Acid; Protein Biosynthesis; Reticulocytes; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Sulfur Radioisotopes; Transcription Factors; Transcription, Genetic; Transfection; Tritium | 1993 |
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
Investigation of the role of lipids in the assembly of very low density lipoproteins in rabbit hepatocytes.
Topics: Acyltransferases; Animals; Apolipoproteins B; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, Thin Layer; Diacylglycerol O-Acyltransferase; Endoplasmic Reticulum, Rough; Endoplasmic Reticulum, Smooth; Enzyme-Linked Immunosorbent Assay; Glycerol; Lipid Metabolism; Lipoproteins, VLDL; Liver; Membrane Lipids; Methionine; Mevalonic Acid; Microsomes, Liver; NADH Dehydrogenase; Oleic Acid; Rabbits; Sterol O-Acyltransferase; Triiodobenzoic Acids | 1997 |
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
Topics: Acute Disease; Apoptosis; Benzamides; Deoxyuracil Nucleotides; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Tumor Cells, Cultured | 2001 |
Isoprenoids influence expression of Ras and Ras-related proteins.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cycloheximide; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; K562 Cells; Leucine; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; rap1 GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Time Factors; Transcription, Genetic; Up-Regulation | 2002 |
Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL.
Topics: Animals; Cell Count; Cells, Cultured; Diterpenes; Glucosamine; Haplorhini; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Methionine; Mevalonic Acid; Muscle, Smooth, Vascular; Protein Binding; Proteoglycans | 2003 |
INCORPORATION OF LABELLED COMPOUNDS INTO AFLATOXINS.
Topics: Acetates; Aflatoxins; Antitoxins; Aspergillus; Carbon Isotopes; Cinnamates; Lactones; Metabolism; Methionine; Mevalonic Acid; Pharmacology; Phenylalanine; Proteins; Research; Shikimic Acid; Toxins, Biological; Tryptophan; Tyrosine; Ultraviolet Rays | 1964 |
Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
Topics: Alkyl and Aryl Transferases; Benzamides; Cell Division; Colonic Neoplasms; Enzyme Inhibitors; Humans; Methionine; Mevalonic Acid; Neoplasm Invasiveness; Pancreatic Neoplasms; Protein Prenylation; Signal Transduction; Tumor Cells, Cultured | 2003 |
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Benzamides; Botulinum Toxins; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Lymphoma; Melanoma, Experimental; Membrane Proteins; Methionine; Mevalonic Acid; Mice; Pyrroles; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering | 2007 |
Metabolic labeling of prenyl and carboxyl-methyl groups.
Topics: Animals; Cells, Cultured; Humans; Indicators and Reagents; Isotope Labeling; Methionine; Methylation; Mevalonic Acid; Protein O-Methyltransferase; Protein Prenylation; Protein Processing, Post-Translational; Proteins; S-Adenosylmethionine; Tritium | 2001 |
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing | 2008 |
High-content assay to study protein prenylation.
Topics: Cell Line, Tumor; Cell Membrane; Dimethylallyltranstransferase; Diphosphonates; Enzyme Inhibitors; Genes, Reporter; Geranyltranstransferase; Green Fluorescent Proteins; Humans; Image Processing, Computer-Assisted; Imidazoles; Luciferases; Methionine; Mevalonic Acid; Protein Prenylation; ras Proteins; Reproducibility of Results; RNA, Small Interfering; Transfection; Zoledronic Acid | 2008 |
Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway.
Topics: Acute Kidney Injury; Animals; Apolipoproteins E; Cholesterol; Creatinine; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Kidney; Male; Methionine; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Pravastatin; Reperfusion Injury; Terpenes | 2008 |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin | 2009 |
Simvastatin represses protein synthesis in the muscle-derived C₂C₁₂ cell line with a concomitant reduction in eukaryotic initiation factor 2B expression.
Topics: Blotting, Western; Cell Line; Cysteine; Eukaryotic Initiation Factor-2B; Guanine Nucleotides; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Methionine; Mevalonic Acid; Muscle Cells; Muscle Proteins; Protein Synthesis Inhibitors; Simvastatin | 2011 |
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.
Topics: Adult; Airway Remodeling; Alkyl and Aryl Transferases; Asthma; Bronchi; Case-Control Studies; Cells, Cultured; Dose-Response Relationship, Drug; Farnesyltranstransferase; Fibroblasts; Fibronectins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin; Time Factors; Transforming Growth Factor beta1; Young Adult | 2011 |
Biosynthesis of integric acid isolated from the wood-decay fungus Xylaria feejeensis 2FB-PPM08M.
Topics: Acetates; Carbon Isotopes; Carboxylic Acids; Isotope Labeling; Metabolic Networks and Pathways; Methionine; Mevalonic Acid; Naphthalenes; Polyketides; Sesquiterpenes; Xylariales | 2015 |