methionine has been researched along with methotrexate in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (57.69) | 18.7374 |
| 1990's | 14 (17.95) | 18.2507 |
| 2000's | 7 (8.97) | 29.6817 |
| 2010's | 11 (14.10) | 24.3611 |
| 2020's | 1 (1.28) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Blakley, RL; Cocco, L; London, RE; Matwiyoff, NA; Walker, TE | 1 |
| Poirier, LA | 1 |
| Barak, AJ; Sorrell, MF; Tuma, DJ | 1 |
| Fry, DW; Goldman, ID; White, JC | 1 |
| Bertino, JR; Chello, PL | 1 |
| Grzelakowska-Sztabert, B | 1 |
| Blakley, RL; Gleisner, JM | 1 |
| Kutsenko, NS | 1 |
| Refsum, H; Ueland, PM; Wesenberg, F | 1 |
| Galivan, J; Pupons, A; Rhee, MS | 1 |
| Billiau, A; Dijkmans, R; Heremans, H | 1 |
| Galivan, J; Johnson, TB; Nair, MG | 1 |
| Galivan, J; Johnson, TB; Priest, DG; Rhee, MS | 1 |
| Helland, S; Refsum, H; Ueland, PM | 1 |
| Allen, RH; Broxson, EH; Kolhouse, JF; Stabler, SP; Stork, LC | 1 |
| Borghi, E; Borowy, F; de Blois, MC; Lejeune, J; Maunoury-Burolla, C; Mir, M; Nicolle, L; Recan, D; Rethoré, MO | 1 |
| Cashmore, AR; Dreyer, RN; Kashani-Sabet, M; Moroson, BA; Pallai, M; Saketos, M; Scanlon, KJ | 1 |
| Galivan, J; Johnson, T; Kesevan, V; McGuire, JJ; Priest, D; Rhee, M | 1 |
| Kvinnsland, S; Refsum, H; Ueland, PM | 1 |
| Cashmore, AR; Kashani-Sabet, M; Moroson, BA; Pallai, M; Saketos, M; Scanlon, KJ | 1 |
| Sourial, NA | 1 |
| Gawthorne, JM; Smith, RM | 1 |
| Bertino, JR; Nahas, A; Nixon, PF; Slutsky, G | 1 |
| Jungkind, DL; Wood, RC | 1 |
| Potter, VR; Sneider, TW | 1 |
| Freeman, KB; Wallace, RB | 1 |
| Jaenicke, L; Sauer, H | 1 |
| Blakley, RL; Gleisner, JM; Peterson, DL | 1 |
| Dunlap, RB; Loeble, RB | 1 |
| Argoudelis, AD; Johnson, LE; Pyke, TR | 1 |
| Eyre, HJ; Perry, S; Rosen, PJ | 1 |
| Gerron, GG; Howard, CH; Rudman, D; Vogler, WR | 1 |
| Lin, MS; Winchell, HS | 1 |
| Herbert, V; Kelly, A; Metz, J; Swett, VC; Waxman, S | 1 |
| Herbert, V; Metz, J; Waxman, S | 1 |
| Scott, JM; Weir, DG | 1 |
| Barak, AJ; Beckenhauer, HC; Tuma, DJ | 1 |
| Barak, AJ; Tuma, DJ | 1 |
| Belousova, AK; Gerasimova, GK; Greshilov, MM; Vorontsov, IN | 2 |
| Barak, AJ; Kemmy, RJ | 1 |
| Bastow, KF; Cheng, YC; Domin, BA; Grill, SP | 1 |
| Tisdale, MJ | 1 |
| Hida, K; Kano, Y; Kubota, T; Sakamoto, S; Sakuraya, K; Suda, K; Takaku, F | 1 |
| Balińska, M; Lewandowska, I; Paszewski, A; Sikora, E; Szablewska, I | 1 |
| Boles, JO; Dunlap, RB; Lebioda, L; Odom, JD | 1 |
| Boles, JO; Dunlap, B; Hatada, M; Kunkle, M; Lebioda, L; Lewinski, K; Odom, JD | 1 |
| Rafter, GW | 1 |
| Blom, HJ; Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM | 1 |
| Carrera, CJ; Carson, DA; Hori, H; Hori, Y; Nobori, T; Rosenbach, MD; Tran, P | 1 |
| Crowe, SF; Ross, CK | 1 |
| Abad, LW; Dellaripa, P; Muldoon, BA; Nadeau, MR; Rosenberg, IH; Roubenoff, R; Selhub, J | 1 |
| Chen, ZH; Olopade, OI; Savarese, TM | 1 |
| Clelland, J; Hann, I; Surtees, R | 1 |
| Dietrich, A; Ehrlich, W; Grätz, R; Kröger, H; Wild, A | 1 |
| Bache, K; Hauschild, A; Kröger, H; Krüger, D; Ohde, M; Thefeldt, W; Voigt, WP | 1 |
| Gaylor, DW; Gibson, JB; Hine, RJ; James, SJ; Melnyk, S; Pogribna, M; Pogribny, IP; Swenson, DH; Tafoya, DL; Wilson, VL; Yi, P | 1 |
| Varela-Moreiras, G | 1 |
| FRIEDKIN, M | 1 |
| BENNETT, JH; HAMLIN, EM; MAIBACH, HI; REES, RB | 1 |
| Garfield, S; Gottesman, MM; Liang, XJ; Shen, DW | 1 |
| Budu, P; Nijhout, HF; Reed, MC; Ulrich, CM | 1 |
| Farmand, S; Fliessbach, K; Kleczar, N; Klockgether, T; Linnebank, M; Orlopp, K; Pels, H; Schlegel, U; Schmidt-Wolf, IG; Urbach, H | 1 |
| Barrett, DA; Fouladi-Nashta, AA; Halliday, N; Li, D; Sinclair, KD; Singh, R | 1 |
| Bangard, C; Glasmacher, A; Jürgens, A; Linnebank, M; Moskau, S; Orlopp, K; Pels, H; Schlegel, U; Schmidt-Wolf, IG; Semmler, A; Simon, M; Urbach, H; Vogt-Schaden, M | 1 |
| Estlin, EJ; McGown, A; Najim, N; Podmore, ID | 1 |
| Ackermann, R; Fornoff, F; Hattingen, E; Linnebank, M; Maurer, GD; Semmler, A; Steinbach, JP | 1 |
| Lee, AL; Mauldin, RV | 1 |
| Adamiak, SJ; Gwynn, A; Kwong, WY; Sinclair, KD; Singh, R | 1 |
| Chiang, EP; Wang, YC | 1 |
| Choi, JY; Jang, SJ; Kim, BT; Kim, SJ; Kim, WS; Lee, JY; Lee, KH | 1 |
| Bangard, C; Egerer, G; Kowoll, A; Linnebank, M; Moskau, S; Pels, H; Reichmann, H; Schackert, G; Schlegel, U; Schmidt-Wolf, IG; Semmler, A; Vogt-Schaden, M | 1 |
| Adachi, S; Heike, T; Kubota, M; Nakata, R; Shima, M; Takeshita, Y; Watanabe, K | 1 |
| Baird, SF; Forster, VJ; Halsey, C; Mair, S; Skinner, R; van Delft, FW | 1 |
| Albrecht, LV; Bui, MH; De Robertis, EM | 1 |
| Bokkers, BGH; de Leeuw, VC; Piersma, AH; van Nieuwland, M | 1 |
5 review(s) available for methionine and methotrexate
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Radioisotope labels for the study of leukocyte kinetics. II.
Topics: Autoradiography; Chromium Isotopes; Humans; Kinetics; Leukocytes; Methionine; Methods; Methotrexate; Radioisotopes; Radionuclide Imaging; Selenium; Sulfur; Tritium | 1971 |
Betaine, metabolic by-product or vital methylating agent?
Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates | 1983 |
Nutritional regulation of homocysteine: effects of drugs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Drug Interactions; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; S-Adenosylmethionine; Vitamin B 12; Vitamin B 6 | 2001 |
ENZYMATIC ASPECTS OF FOLIC ACID.
Topics: Amidohydrolases; Aminopterin; Chromatography; Clostridium; Escherichia coli; Floxuridine; Folic Acid; Ligases; Liver; Lyases; Methionine; Methotrexate; Micrococcus; Oxidoreductases; Pseudomonas; Research; Spectrophotometry; Transferases; Tritium; Vitamin B 12 | 1963 |
1 trial(s) available for methionine and methotrexate
| Article | Year |
|---|---|
Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies.
Topics: Antidotes; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Demyelinating Diseases; Drug Interactions; Humans; Infant; Leucovorin; Methionine; Methotrexate; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Tetrahydrofolates | 1998 |
72 other study(ies) available for methionine and methotrexate
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Nuclear magnetic resonance studies on bacterial dihydrofolate reductase containing [methyl-13C]methionine.
Topics: Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Methionine; Methotrexate; NADP; Nucleotides; Pteridines; Streptococcus; Temperature; Tetrahydrofolate Dehydrogenase | 1978 |
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.
Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methotrexate; Neoplasms, Experimental; Nitrosamines; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Vitamin B 12 | 1975 |
Interaction of methotrexate with lipotropic factors in rat liver.
Topics: Animals; Cholesterol; Choline; Choline Deficiency; Diet; Drug Synergism; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Phospholipids; Rats; Triglycerides; Vitamin B 12 | 1975 |
Rapid separation of low molecular weight solutes from liposomes without dilution.
Topics: Chromatography, Gel; Folic Acid; Inulin; Leucine; Liposomes; Methionine; Methotrexate; Sucrose; Thymidine | 1978 |
Effect of methionine deprivation on L5178Y murine leukemia cells in culture interference with the antineoplastic effect of methotrexate.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Leukemia, Experimental; Methionine; Methotrexate; Mice; Time Factors | 1976 |
Uptake of folate and its analogue-amethopterin by mouse L-cells.
Topics: Animals; Cells, Cultured; Chloromercuribenzoates; Cycloheximide; Dactinomycin; Folic Acid; Kinetics; L Cells; Methionine; Methotrexate; Mice; Vitamin B 12 | 1976 |
The structure of dihydrofolate reductase. I. Inactivation of bacterial dihydrofolate reductase concomitant with modification of a methionine residue at the active site.
Topics: Binding Sites; Circular Dichroism; Dialysis; Drug Resistance, Microbial; Folic Acid Antagonists; Iodoacetates; Kinetics; Mathematics; Methionine; Methotrexate; Mutation; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Streptococcus; Tetrahydrofolate Dehydrogenase; Time Factors | 1975 |
[Use of a preparation of serum albumin in the complex treatment of patients with true pemphigus].
Topics: Adult; Aged; Anti-Bacterial Agents; Calcium; Drug Evaluation; Glucocorticoids; Humans; Methionine; Methotrexate; Middle Aged; Pemphigus; Potassium; Serum Albumin; Vitamins | 1975 |
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1991 |
Hepatic parenchymal cell glutamylation of methotrexate studied in monolayer culture.
Topics: Animals; Cells, Cultured; Glutamates; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Methionine; Methotrexate; Polyglutamic Acid; Rats | 1986 |
Heterogeneity of Chinese hamster ovary cell-produced recombinant murine interferon-gamma.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cysteine; Electrophoresis, Polyacrylamide Gel; Female; Glycosylation; Interferon-gamma; Methionine; Methotrexate; Mice; Molecular Weight; Ovary; Poly A; Recombinant Proteins; RNA; RNA, Messenger | 1987 |
Role of folylpolyglutamate synthetase in the regulation of methotrexate polyglutamate formation in H35 hepatoma cells.
Topics: Animals; gamma-Glutamyl Hydrolase; Liver Neoplasms, Experimental; Methionine; Methotrexate; Peptide Biosynthesis; Peptide Synthases; Polyglutamic Acid; Rats; Tumor Cells, Cultured | 1988 |
The effect of methionine on methotrexate metabolism in rat hepatocytes in monolayer culture.
Topics: Animals; Cells, Cultured; Folic Acid; Glutamates; Glutamic Acid; Hydroxylation; Liver; Male; Methionine; Methotrexate; Rats; Rats, Inbred Lew | 1989 |
Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment.
Topics: Adult; Aged; Aged, 80 and over; Fasting; Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Psoriasis; Regression Analysis | 1989 |
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
[Metabolism of monocarbons and trisomy 21: sensitivity to methotrexate].
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Down Syndrome; Homocysteine; Humans; Lymphocytes; Methionine; Methotrexate; Mitotic Index; Purines | 1986 |
Inhibition of methionine uptake by methotrexate in mouse leukemia L1210 cells.
Topics: Animals; Biological Transport, Active; Cell Line; Depression, Chemical; Leukemia L1210; Methionine; Methotrexate; Mice; Serine | 1987 |
The role of folylpolyglutamate synthetase and gamma-glutamyl hydrolase in altering cellular folyl- and antifolylpolyglutamates.
Topics: Animals; Cysteine Endopeptidases; Folic Acid; gamma-Glutamyl Hydrolase; Liver; Liver Neoplasms, Experimental; Male; Methionine; Methotrexate; Peptide Synthases; Pteroylpolyglutamic Acids; Rats; Rats, Inbred Lew | 1987 |
Acute and long-term effects of high-dose methotrexate treatment on homocysteine in plasma and urine.
Topics: Adolescent; Adult; Cells, Cultured; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Tetrahydrofolates | 1986 |
The role of methionine in methotrexate-sensitive and methotrexate-resistant mouse leukemia L1210 cells.
Topics: Animals; Biological Transport, Active; Cell Line; Cisplatin; Drug Resistance; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methionine; Methotrexate; Mice; Neoplasm Proteins; Sodium | 1987 |
Re: Effect of nitrous oxide on human bone marrow cells and its synergistic effect with methionine and methotrexate on functional folate deficiency.
Topics: Bone Marrow; Cells, Cultured; Drug Synergism; Folic Acid Deficiency; Humans; Methionine; Methotrexate; Nitrous Oxide | 1985 |
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Female; Folic Acid; Homocysteine; Liver; Membranes; Methionine; Methotrexate; Methyltransferases; NAD; NADP; S-Adenosylmethionine; Serum Albumin, Bovine; Sheep; Tetrahydrofolate Dehydrogenase; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
The turnover of folate coenzymes in murine lymphoma cells.
Topics: Animals; Biological Assay; Carbon Isotopes; Cell Line; Chromatography, Ion Exchange; Coenzymes; Culture Media; Drug Stability; Folic Acid; Glutamates; Lacticaseibacillus casei; Lymphoma; Methionine; Methotrexate; Mice; Neoplasms, Experimental; Pancreas; Peptides; Protein Binding; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymine Nucleotides; Tritium | 1973 |
Factors involved in the synthesis of cyclopropane fatty acids by Streptococcus faecalis.
Topics: Carbon Radioisotopes; Cell Division; Chromatography, Gas; Cyclopropanes; Enterococcus faecalis; Fatty Acids; Folic Acid; Hydrogen-Ion Concentration; Methionine; Methotrexate; Nephelometry and Turbidimetry; Oleic Acids; Temperature; Thymidine; Time Factors | 1974 |
Methylation of mammalian DNA: studies on Novikoff hepatoma cells in tissue culture.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Cytosine Nucleotides; DNA; Liver Neoplasms; Methionine; Methotrexate; Methylation; Neoplasms, Experimental; Purines; Pyrimidines; Rats; Thymine | 1969 |
Initiation of mammalian mitochondrial protein synthesis. The effect of methotrexate.
Topics: Animals; Carbon Radioisotopes; Carcinoma; Cell Count; Cell Division; Cell Line; Electrophoresis, Paper; Formates; L Cells; Methionine; Methotrexate; Mice; Mitochondria; Mouth Neoplasms; Peptide Chain Initiation, Translational; Protein Biosynthesis; Puromycin; RNA, Transfer; Sulfur Radioisotopes; Time Factors; Transcription, Genetic | 1974 |
[Suppression of cytostatic effect of amethopterin (methotrexate) with methyltetrahydrofolic acid].
Topics: Cells, Cultured; Folic Acid; Humans; Leukemia, Myeloid; Lymphocytes; Methionine; Methotrexate; Methyltransferases; Tetrahydrofolates | 1974 |
Amino-acid sequence of dihydrofolate reductase from a methotrexate-resistant mutant of Streptococcus faecium and identification of methionine residues at the inhibitor binding site.
Topics: Amino Acid Sequence; Aminopterin; Binding Sites; Carbon Radioisotopes; Drug Resistance, Microbial; Escherichia coli; Iodoacetates; Methionine; Methotrexate; Mutation; Streptococcus; Tetrahydrofolate Dehydrogenase | 1974 |
Characterization of the subunits of thymidylate synthetase.
Topics: Amino Acids; Chromatography, Thin Layer; Cyanogen Bromide; Dansyl Compounds; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Hydantoins; Lacticaseibacillus casei; Lactobacillus; Leucine; Macromolecular Substances; Methionine; Methotrexate; Methyltransferases; Sodium Dodecyl Sulfate; Sulfhydryl Compounds; Sulfides; Thiocyanates; Thymidylate Synthase | 1972 |
Effect of methylation inhibitors on fermentations of S. lincolnensis. Production of N-demethyllincomycin.
Topics: Aminobenzoates; Aminopterin; Aminosalicylic Acids; Benzoates; Chromatography, Thin Layer; Culture Media; Fermentation; Folic Acid Antagonists; Lincomycin; Methionine; Methotrexate; Methylation; Streptomyces; Sulfadiazine; Sulfaguanidine; Sulfanilamides; Sulfathiazoles; Sulfonamides | 1973 |
Observations on the plasma amino acids of patients with acute leukemia.
Topics: Acute Disease; Alanine; Amino Acids; Asparaginase; Cytarabine; Glucocorticoids; Glutamine; Histidine; Humans; Indicators and Reagents; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methionine; Methotrexate; Nitrogen; Proline; Threonine; Vincristine | 1971 |
Kinetics of amino acid transport across bone marrow cell membranes.
Topics: Amino Acids; Animals; Biological Transport, Active; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Membrane; DNA; Dogs; Extracellular Space; Glucagon; Glutamates; Histidine; Imidazoles; Insulin; Kinetics; Methionine; Methotrexate; Models, Biological; Serine; Time Factors; Tryptophan | 1970 |
Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Female; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymine; Tritium; Uridine; Vitamin B 12; Vitamin B 12 Deficiency | 1968 |
Defective DNA synthesis in human megaloblastic bone marrow: effects of homocysteine and methionine.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Deoxyuridine; DNA; Folic Acid Deficiency; Homocysteine; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymidine; Transferases; Tritium; Vitamin B 12 Deficiency | 1969 |
The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia.
Topics: Acute Disease; Anemia, Pernicious; Bone Marrow; Cell Division; Folic Acid; Folic Acid Deficiency; Humans; Kwashiorkor; Methionine; Methotrexate; Models, Biological; Vitamin B 12 Deficiency | 1981 |
Methotrexate hepatotoxicity.
Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides | 1984 |
[Evaluation of biochemical criteria for sensitivity of tumor cells to methotrexate by means of mathematic simulation].
Topics: Animals; Carcinoma, Ehrlich Tumor; Folic Acid; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Models, Biological; Purines; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
[Mathematical description and study of the folic acid cycle reactions].
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Folic Acid; Humans; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Mice; Purines; Rats; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; Rats, Inbred Strains | 1982 |
Effect of methotrexate on dihydrofolate reductase activity in methotrexate-resistant human KB cells.
Topics: Cells, Cultured; Chemical Precipitation; Drug Resistance; Humans; Kinetics; Methionine; Methotrexate; Nasopharyngeal Neoplasms; Neoplasms, Experimental; Tetrahydrofolate Dehydrogenase; Time Factors | 1982 |
Methionine metabolism in Walker carcinosarcoma in vitro.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma 256, Walker; Cell Survival; Cells, Cultured; Homocysteine; Methionine; Methotrexate; Sulfhydryl Compounds; Thymidine | 1980 |
Effect of nitrous oxide on human bone marrow cells and its synergistic effect with methionine and methotrexate on functional folate deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bone Marrow; Deoxyuridine; DNA; Drug Synergism; Folic Acid Antagonists; Humans; Methionine; Methotrexate; Methyltransferases; Neoplasms; Nitrous Oxide; Pteroylpolyglutamic Acids; Time Factors | 1981 |
Metabolism of folate glutamates in Aspergillus nidulans.
Topics: Aspergillus nidulans; Crosses, Genetic; gamma-Glutamyl Hydrolase; Methionine; Methotrexate; Peptide Synthases; Polyglutamic Acid; Pteroylpolyglutamic Acids | 1993 |
Telluromethionine in structural biochemistry.
Topics: Crystallization; Crystallography, X-Ray; Escherichia coli; Magnetic Resonance Spectroscopy; Methionine; Methotrexate; NADP; Tellurium; Tetrahydrofolate Dehydrogenase | 1995 |
Bio-incorporation of telluromethionine into buried residues of dihydrofolate reductase.
Topics: Bacterial Proteins; Escherichia coli; Methionine; Methotrexate; Models, Molecular; Protein Conformation; Tellurium; Tetrahydrofolate Dehydrogenase | 1994 |
Plasma thiols, copper and rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Copper; Cysteine; Glutathione; Homocysteine; Humans; Methionine; Methotrexate; Models, Biological; Sulfhydryl Compounds | 1994 |
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells.
Topics: Alanine; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Feasibility Studies; Genetic Vectors; Humans; Lung Neoplasms; Methionine; Methotrexate; Neoplasm Proteins; Purine-Nucleoside Phosphorylase; Purines; Tetrahydrofolates; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1996 |
Effect of folate deficiency and folate and B12 excess on memory functioning in young chicks.
Topics: Animals; Avoidance Learning; Chickens; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Memory; Methionine; Methotrexate; Reflex; Time Factors; Vitamin B 12 | 1997 |
Abnormal homocysteine metabolism in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Fasting; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP- malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis.
Topics: Adenosine; Antimalarials; Antimetabolites, Antineoplastic; Azaserine; Biomarkers, Tumor; Cell Count; Deoxyadenosines; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Methionine; Methotrexate; Pancreatic Neoplasms; Purine-Nucleoside Phosphorylase; Purines; RNA, Messenger; Thionucleosides; Tumor Cells, Cultured | 1997 |
The effect of tryptophan plus methionine, 5-azacytidine, and methotrexate on adjuvant arthritis of rat.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Azacitidine; Body Weight; Drug Therapy, Combination; Freund's Adjuvant; Male; Methionine; Methotrexate; Rats; Tryptophan | 1999 |
Nicotinamide and methionine reduce the liver toxic effect of methotrexate.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Liver Diseases; Male; Methionine; Methotrexate; Mice; Mice, Inbred DBA; Niacinamide | 1999 |
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.
Topics: Adult; Alcohol Drinking; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyribonucleases, Type II Site-Specific; Diet Surveys; Diet, Reducing; Dietary Supplements; DNA; Down Syndrome; Electrophoresis, Agar Gel; Female; Folic Acid; Genotype; Homocysteine; Humans; Methionine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymerase Chain Reaction; Risk Factors; Surveys and Questionnaires | 1999 |
AMINOPTERIN FOR PSORIASIS. A DECADE'S OBSERVATION.
Topics: Adrenocorticotropic Hormone; Alanine Transaminase; Aminopterin; Drug Therapy; Folic Acid; Geriatrics; Humans; Kidney Function Tests; Liver Function Tests; Methionine; Methotrexate; Prednisolone; Pregnancy; Psoriasis; Toxicology; Triamcinolone | 1964 |
Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotin; Carbon Radioisotopes; Carboplatin; Carrier Proteins; Cell Membrane; Cisplatin; Cysteine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; KB Cells; Lysosomes; Methionine; Methotrexate; Receptors, Cell Surface; Succinimides; Sulfur Radioisotopes; Triiodobenzoic Acids; Tritium | 2003 |
A mathematical model of the folate cycle: new insights into folate homeostasis.
Topics: Allosteric Site; Animals; Dose-Response Relationship, Drug; Folic Acid; Homeostasis; Humans; Kinetics; Liver; Methionine; Methotrexate; Models, Biological; Models, Chemical; Models, Theoretical; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Up-Regulation; Vitamin B 12 Deficiency | 2004 |
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism.
Topics: Aged; Brain; Central Nervous System Neoplasms; Demyelinating Diseases; DNA Mutational Analysis; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurotoxins; Polymorphism, Genetic; Risk Factors; S-Adenosylmethionine | 2005 |
Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation.
Topics: Adenocarcinoma; Adenosine; Alkaline Phosphatase; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Proliferation; Colonic Neoplasms; Cyclic AMP; Extracellular Signal-Regulated MAP Kinases; HT29 Cells; Humans; Hypoxanthines; MAP Kinase Kinase Kinases; Methionine; Methotrexate; Phosphatidylinositol 3-Kinases; Polyamines; Purines; Signal Transduction; Tetrahydrofolates; Thymidine | 2006 |
Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphoma.
Topics: Antimetabolites, Antineoplastic; Brain; Central Nervous System Neoplasms; Cystathionine beta-Synthase; Female; Humans; Hydroxymethyl and Formyl Transferases; Lymphoma; Male; Methionine; Methionine Sulfoxide Reductases; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Microfilament Proteins; Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Oxidoreductases; Polymorphism, Genetic; Prospective Studies; Tetrahydrofolate Dehydrogenase; Transcobalamins; Transcription Factors; TRPM Cation Channels | 2009 |
Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Proliferation; Cerebellar Neoplasms; Cisplatin; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Fluorometry; Glioma; Glutathione; Humans; Medulloblastoma; Methionine; Methotrexate; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2009 |
Methotrexate-induced myelopathy responsive to substitution of multiple folate metabolites.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Humans; Magnetic Resonance Imaging; Meningeal Carcinomatosis; Methionine; Methotrexate; Middle Aged; Spinal Cord Diseases; Vitamin B Complex | 2010 |
Nuclear magnetic resonance study of the role of M42 in the solution dynamics of Escherichia coli dihydrofolate reductase.
Topics: Escherichia coli Proteins; Methionine; Methotrexate; NADP; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Secondary; Tetrahydrofolate Dehydrogenase; Thermodynamics; Tryptophan | 2010 |
Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo.
Topics: Animals; Blastocyst; Carbohydrate Metabolism; Carbon; Cattle; Cells, Cultured; Female; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Metabolic Networks and Pathways; Methionine; Methotrexate; Models, Biological; Oocytes; Ovarian Follicle; Sheep | 2010 |
Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo.
Topics: Animals; Antirheumatic Agents; Dactinomycin; Dexamethasone; Enzyme Inhibitors; Folic Acid; Gene Expression Regulation; Hep G2 Cells; Humans; Male; Methionine; Methionine Adenosyltransferase; Methotrexate; Mice; Mice, Inbred C57BL; RNA, Messenger; S-Adenosylmethionine | 2012 |
(11)C-methionine PET/CT and MRI of primary central nervous system diffuse large B-cell lymphoma before and after high-dose methotrexate.
Topics: Antineoplastic Agents; Brain; Dose-Response Relationship, Drug; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Male; Methionine; Methotrexate; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Tomography, X-Ray Computed; Treatment Outcome | 2012 |
Association of transcobalamin c. 776C>G with overall survival in patients with primary central nervous system lymphoma.
Topics: Adult; Aged; Central Nervous System Neoplasms; Female; Genotype; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Mutation, Missense; Survival Analysis; Transcobalamins | 2012 |
Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity.
Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Homocysteine; Humans; Liver Function Tests; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine | 2014 |
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Humans; Leukemia; Methionine; Methotrexate; Myelin Sheath; Neurotoxicity Syndromes; Nitrous Oxide; Nutritional Status; Seizures; Vitamin B 12 Deficiency | 2016 |
Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.
Topics: Carbon; Endosomes; Glycogen Synthase Kinase 3 beta; HEK293 Cells; HeLa Cells; Humans; Lysosomes; Methionine; Methotrexate; Methylation; Niacinamide; Protein-Arginine N-Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Wnt Signaling Pathway | 2019 |
Culture Conditions Affect Chemical-Induced Developmental Toxicity
Topics: Animals; Cell Culture Techniques; Cell Line; Embryonic Stem Cells; Folic Acid; Methionine; Methotrexate; Mice; Neural Stem Cells | 2020 |