Page last updated: 2024-08-17

methionine and lovastatin

methionine has been researched along with lovastatin in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.81)18.7374
1990's13 (48.15)18.2507
2000's8 (29.63)29.6817
2010's2 (7.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Casey, WM; Keesler, GA; Parks, LW1
Bereziat, G; Chambaz, J; Janvier, B; Loriette, C; Mangeney, M; Pepin, D; Ribeiro, A; Thomas, G1
Beck, L; Leonard, S; Sinensky, M1
Fliesler, SJ; Keller, RK1
Buddecke, E; Filipovic, I1
Don, HS; Shiao, MS1
Knight, BL; Patel, DD; Soutar, AK1
Jeng, I; Klemm, N; Proctor, B1
Hohl, RJ; Lewis, K1
D'Andrea, P; Grossman, JS; Latter, GI; Patterson, SD1
Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A2
Hamilton, AD; Qian, Y; Sebti, SM; Sun, J; Vogt, A1
Blaskovich, MA; Davies, P; Hamilton, AD; Johnson, BA; Pitt, B; Qian, Y; Sebti, SM; Stark, WW; Vasudevan, A1
Bifulco, M; Di Matola, T; Fenzi, G; Laezza, C; Rossi, G; Vitale, M1
Dumont, JE; Fusco, A; Golstein, J; Kimura, T1
Bailey, R; Hamilton, AD; Harlan, JM; Kovach, NL; Liu, L; Moesner, P; Sebti, SM1
Aklilu, F; Gladu, J; Goltzman, D; Rabbani, SA1
Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z1
Bannerman, DD; Hamilton, AD; Harlan, JM; Li, X; Liu, L; Sebti, SM; Tupper, JC; Winn, RK1
Hohl, RJ; Holstein, SA; Wohlford-Lenane, CL1
Efuet, ET; Keyomarsi, K1
Broers, JL; Hennekam, RC; Kamps, M; Kuijpers, HJ; Marcelis, CL; Merckx, D; Ramaekers, FC; Smeets, HJ; Steijlen, PM; van den Wijngaard, A; van Steensel, MA; Verstraeten, VL; Zinn-Justin, S1
Beck, JF; Bumbul, B; Sonnemann, J1
Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1

Reviews

1 review(s) available for methionine and lovastatin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

26 other study(ies) available for methionine and lovastatin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Stimulation by heme of steryl ester synthase and aerobic sterol exclusion in the yeast Saccharomyces cerevisiae.
    Archives of biochemistry and biophysics, 1992, Aug-01, Volume: 296, Issue:2

    Topics: Acyltransferases; Aerobiosis; Aminolevulinic Acid; Esterification; Fatty Acids, Unsaturated; Heme; Lovastatin; Methionine; Saccharomyces cerevisiae; Sterol O-Acyltransferase; Sterols

1992
Effect of simvastatin on the synthesis and secretion of lipoproteins in relation to the metabolism of cholesterol in cultured hepatocytes.
    Biochimica et biophysica acta, 1991, Nov-27, Volume: 1086, Issue:3

    Topics: Animals; Animals, Newborn; Cells, Cultured; Cholesterol; Cholesterol Esters; Fatty Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Liver; Lovastatin; Male; Methionine; Rats; Rats, Inbred Strains; Simvastatin; Triglycerides

1991
Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.
    The Journal of biological chemistry, 1990, Mar-25, Volume: 265, Issue:9

    Topics: Animals; Cell Line; Cholesterol; Genes, ras; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Methionine; Mevalonic Acid; Oncogene Protein p21(ras); Protein Precursors; Protein Processing, Post-Translational; Transfection

1990
Incorporation of squalene into rod outer segments.
    The Journal of biological chemistry, 1990, Aug-15, Volume: 265, Issue:23

    Topics: Acetates; Animals; Cell Membrane; Cysteine; Lovastatin; Membrane Lipids; Membrane Proteins; Methionine; Photoreceptor Cells; Puromycin; Rana pipiens; Retina; Rod Cell Outer Segment; Squalene; Sulfur Radioisotopes; Tritium

1990
Calmodulin antagonists stimulate LDL receptor synthesis in human skin fibroblasts.
    Biochimica et biophysica acta, 1986, Mar-21, Volume: 876, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Acetates; Acetic Acid; Androstenes; Calcium Chloride; Calmodulin; Cholera Toxin; Cholesterol; Cyclic AMP; Fibroblasts; Humans; Hydroxycholesterols; Lovastatin; Methionine; Mevalonic Acid; Molecular Weight; Naphthalenes; p-Methoxy-N-methylphenethylamine; Receptors, LDL; Skin; Sulfonamides; Trifluoperazine

1986
Biosynthesis of mevinolin, a hypocholesterolemic fungal metabolite, in Aspergillus terreus.
    Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1987, Volume: 11, Issue:3

    Topics: Anticholesteremic Agents; Aspergillus; Butyrates; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Lovastatin; Methionine; Methylation; S-Adenosylmethionine; T-2 Toxin; Tritium

1987
Regulation of synthesis and cell content of the low-density-lipoprotein receptor protein in cultured fibroblasts from normal and familial hypercholesterolaemic subjects.
    European journal of biochemistry, 1987, Feb-16, Volume: 163, Issue:1

    Topics: Acetates; Cell Membrane; Cells, Cultured; Cholesterol; Fibroblasts; Humans; Hyperlipoproteinemia Type II; Immunochemistry; Lipoproteins; Lovastatin; Methionine; Naphthalenes; Radioimmunoassay; Receptors, LDL

1987
Insensitivity of ubiquinone biosynthesis in glioblastoma cells to an epileptogenic drug, U18666A.
    Journal of neurochemistry, 1984, Volume: 43, Issue:5

    Topics: Androstenes; Animals; Anticholesteremic Agents; Cell Line; Glioma; Hydroxybenzoates; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Methionine; Mevalonic Acid; Naphthalenes; Parabens; Rats; Tyrosine; Ubiquinone

1984
Differential effects of monoterpenes and lovastatin on RAS processing.
    The Journal of biological chemistry, 1995, Jul-21, Volume: 270, Issue:29

    Topics: Cells, Cultured; Cyclohexenes; Humans; Limonene; Lovastatin; Methionine; Monoterpenes; ras Proteins; Terpenes

1995
Reduced numatrin/B23/nucleophosmin labeling in apoptotic Jurkat T-lymphoblasts.
    The Journal of biological chemistry, 1995, Apr-21, Volume: 270, Issue:16

    Topics: Apoptosis; Cells, Cultured; Cysteine; Egtazic Acid; Electrophoresis, Gel, Two-Dimensional; Humans; Lovastatin; Methionine; Nuclear Proteins; Nucleophosmin; T-Lymphocytes

1995
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
    The Journal of biological chemistry, 1996, Nov-01, Volume: 271, Issue:44

    Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyltranstransferase; Kinetics; Lovastatin; Methionine; Mice; Phosphorylation; Phosphotyrosine; Protein Prenylation; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Structure-Activity Relationship; Transfection; Transferases

1996
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
    Oncogene, 1996, Nov-07, Volume: 13, Issue:9

    Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases

1996
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
    The Journal of biological chemistry, 1997, Oct-24, Volume: 272, Issue:43

    Topics: Alkyl and Aryl Transferases; Benzamides; Breast Neoplasms; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Female; Fibrosarcoma; G1 Phase; Head and Neck Neoplasms; Humans; Lovastatin; Methionine; Oligopeptides; Pancreatic Neoplasms; Protein Prenylation; Resting Phase, Cell Cycle; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms

1997
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
    The American journal of physiology, 1998, Volume: 275, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Benzamides; Cell Division; Cells, Cultured; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; GTP-Binding Proteins; Kinetics; Lovastatin; Methionine; Microcirculation; Muscle, Smooth, Vascular; Protein Prenylation; Pulmonary Artery; rap GTP-Binding Proteins; ras Proteins; Rats; Transcription Factors

1998
Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism.
    Endocrinology, 1999, Volume: 140, Issue:2

    Topics: Apoptosis; Benzamides; Caspases; Cell Division; Cell Line; Cysteine Proteinase Inhibitors; Dimethylallyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Methionine; Serpins; Thyroid Gland; Tumor Suppressor Protein p53; Viral Proteins

1999
Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: comparison with FRTL-5 cells.
    European journal of endocrinology, 1999, Volume: 140, Issue:1

    Topics: Animals; Cell Division; Cell Line, Transformed; Cell Size; DNA; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Lovastatin; Methionine; Protein Biosynthesis; Rats; Sulfur Radioisotopes; Thyrotropin

1999
Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s).
    The Journal of biological chemistry, 1999, Nov-19, Volume: 274, Issue:47

    Topics: Benzamides; Cell Adhesion; Diterpenes; Fibronectins; Humans; Integrins; Jurkat Cells; Leukocytes; Lovastatin; Methionine; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; U937 Cells

1999
Role of mitogen-activated protein kinases in the induction of parathyroid hormone-related peptide.
    Cancer research, 2000, Mar-15, Volume: 60, Issue:6

    Topics: Animals; Antineoplastic Agents; Calcium; Cycloheximide; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Lovastatin; Male; Methionine; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Neoplasms, Experimental; Parathyroid Hormone-Related Protein; Proteins; Proto-Oncogene Proteins c-raf; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred F344; RNA, Messenger; Signal Transduction; Ultraviolet Rays

2000
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
    Leukemia, 2001, Volume: 15, Issue:9

    Topics: Acute Disease; Apoptosis; Benzamides; Deoxyuracil Nucleotides; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Tumor Cells, Cultured

2001
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
    The Journal of biological chemistry, 2002, May-03, Volume: 277, Issue:18

    Topics: Apoptosis; Benzamides; Caspase 3; Caspases; Cell Death; Cells, Cultured; Diterpenes; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Lovastatin; Methionine; Polyisoprenyl Phosphates; Protein Prenylation; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Umbilical Veins

2002
Isoprenoids influence expression of Ras and Ras-related proteins.
    Biochemistry, 2002, Nov-19, Volume: 41, Issue:46

    Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cycloheximide; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; K562 Cells; Leucine; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; rap1 GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Time Factors; Transcription, Genetic; Up-Regulation

2002
Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
    Cancer research, 2006, Jan-15, Volume: 66, Issue:2

    Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; G1 Phase; Humans; Lactic Acid; Lovastatin; Methionine; Proteasome Endopeptidase Complex; Protein Prenylation; rap1 GTP-Binding Proteins; ras Proteins; Tumor Cells, Cultured; Up-Regulation

2006
Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation.
    Human molecular genetics, 2006, Aug-15, Volume: 15, Issue:16

    Topics: Adult; Bone and Bones; Cell Survival; Cells, Cultured; Child, Preschool; Female; Fibroblasts; Heterozygote; Humans; Imaging, Three-Dimensional; Immunohistochemistry; Lamin Type A; Lovastatin; Male; Methionine; Models, Molecular; Mutation; Nuclear Proteins; Progeria; Protein Precursors; Protein Prenylation; Radiography

2006
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:11

    Topics: Antineoplastic Agents; Benzamides; Cell Death; Cell Line, Tumor; Diphosphonates; Drug Screening Assays, Antitumor; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Imidazoles; Lovastatin; Male; Methionine; Mitochondria; Prostatic Neoplasms; Vorinostat; Zoledronic Acid

2007
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
    Molecular pharmacology, 2008, Volume: 73, Issue:5

    Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing

2008