methionine has been researched along with l 744832 in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (26.19) | 18.2507 |
| 2000's | 26 (61.90) | 29.6817 |
| 2010's | 5 (11.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anthony, NJ; Conner, MW; Davide, JP; deSolms, SJ; Giuliani, EA; Gomez, RP; Graham, SL; Hamilton, K; Kohl, NE; Omer, CA | 1 |
| Barrington, RE; Bearss, DJ; Conner, MW; Gibbs, JB; Hamilton, K; Hundley, JE; Koblan, KS; Koester, SK; Kohl, NE; Miller, PJ; Mosser, SD; O'Neill, TJ; Oliff, A; Omer, CA; Rands, E; Schaber, MD; Senderak, ET; Subler, MA; Troyer, DA; Windle, JJ | 1 |
| Balog, A; Danishefsky, SJ; Kohl, NE; Moasser, MM; Oliff, A; Rosen, N; Sepp-Lorenzino, L; Su, DS | 1 |
| Corral, T; Gibbs, JB; Kohl, NE; Lu, S; Malumbres, M; Mangues, R; Oliff, A; Pellicer, A; Symmans, WF | 1 |
| Rosen, N; Sepp-Lorenzino, L | 1 |
| Coffey, RJ; Joseph, H; Kohl, NE; Law, B; Mays, D; Moses, HL; Nørgaard, P; Oliff, A; Page, DL; Pietenpol, JA; Poulsen, HS; Shyr, Y | 1 |
| Gnudi, L; Kahn, BB; Law, BK; Moses, HL; Nørgaard, P; Poulson, HS | 1 |
| Du, W; Lebowitz, PF; Prendergast, GC | 1 |
| Gibbs, JB; Gratiot, M; Jacks, T; Kohl, NE; Mahgoub, N; Shannon, KM; Taylor, BR | 1 |
| Feldkamp, MM; Guha, A; Lau, N | 2 |
| Castleberry, RP; Emanuel, PD; Gopurala, B; Snyder, RC; Wiley, T | 1 |
| Law, BK; Moses, HL; Norgaard, P | 1 |
| Abrams, MT; Bhimnathwala, H; Chen, HY; Chen, Z; Conner, MW; Davide, JP; Diehl, RE; Ellis, MS; Gibbs, JB; Gopal-Truter, S; Greenberg, I; Koblan, KS; Kohl, NE; Kral, AM; Liu, D; Lobell, RB; Miller, PJ; Mosser, SD; O'Neill, TJ; Oliff, A; Omer, CA; Rands, E; Schaber, MD; Seeburger, G; Senderak, ET; Trumbauer, ME | 1 |
| Kohl, NE; Rosen, N; Scher, HI; Sepp-Lorenzino, L; Sirotnak, FM | 1 |
| Bernhard, EJ; Cerniglia, G; Cohen-Jonathan, E; Evans, SM; Gibbs, JB; Gillies McKenna, W; Hamilton, AD; Kohl, N; Kusewitt, D; Mick, R; Muschel, RJ; Oliff, A; Sebti, SM | 1 |
| Andres, DA; Chan, TO; Cox, AD; Grana, TM; Reynolds, ER; Rusyn, EV; Shao, H | 1 |
| Bernhard, EJ; Cohen-Jonathan, E; Evans, SM; Koch, CJ; McKenna, WG; Muschel, RJ; Wu, J | 1 |
| Ahmed, MM; Alcock, RA; Chatfield, LK; Chendil, D; Dey, S; Gallicchio, VS; Hartman, G; Inayat, MS; Mohiuddin, M | 1 |
| Bao, L; DiVito, MM; Merajver, SD; Prendergast, GC; van Golen, KL; Wu, Z | 1 |
| Bos, CL; Peppelenbosch, MP; Rens, LS; Richel, DJ; Vervenne, WL | 1 |
| Chintapalli, J; Du, W; Prendergast, GC; Rane, N; Zeng, PY | 1 |
| Baker, J; Donover, S; Du, W; DuHadaway, JB; Liu, AX; Muller, AJ; Prendergast, GC; Sharp, DM | 1 |
| Birkenkamp, KU; Geugien, M; Lemmink, HH; Schepers, H; Vellenga, E; Westra, J | 1 |
| Golab, J; Jakobisiak, M; Kopec, M; Legat, M; Makowski, M; Strusinska, K | 1 |
| Bernhard, EJ; Cerniglia, GJ; Cohen-Jonathan, E; Koch, CJ; Mick, R; Rhim, JS; Shi, Y; Wu, J | 1 |
| Dai, Y; Dent, P; Grant, S; Han, SI; Khanna, P; Mitchell, C; Pei, XY; Rahmani, M | 1 |
| Cresswell, P; Lu, YE; Modiano, N | 1 |
| Dai, Y; Dent, P; Grant, S; Li, W; Pei, XY; Rahmani, M | 1 |
| Aydin, F; Kavgaci, H; Ovali, E; Ozdemir, F; Yavuz, A; Yavuz, M | 1 |
| Kennedy, S; Wadsworth, RM; Wainwright, CL | 1 |
| Berk, S; Gajewski, TF; Ho, AW; Kuna, T; Marks, RE; Robbel, C | 1 |
| Kramer, MP; Schmid, G; Wesierska-Gadek, J | 1 |
| Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I | 1 |
| Cummings, KS; Ji, JY; Lammerding, J; Lee, RT; Verstraeten, VL | 1 |
| Bishop, JM; Charoenthongtrakul, S; Field, KA; Refaeli, Y | 1 |
| Burne-Taney, MJ; Ikeda, M; Ito, K; Kumagai, K; Mori, M; Rabb, H; Sharyo, S; Uchida, K; Yokota-Ikeda, N | 1 |
| Hackl, S; Kramer, M; Siska, P; Weber, F; Wesierska-Gádek, J; Zulehner, N | 1 |
| Borochoff-Porte, N; Johnson, DI; Midkiff, J; White, D | 1 |
| Moore, T; Murphy, LA; Nesnow, S | 1 |
| Ablao, KP; Bodmer, R; Dhahbi, JM; Li, R; Mote, P; Ocorr, K; Spindler, SR; Wang, Y; Williams, RT; Yamakawa, A | 1 |
| Basak, GW; Bil, J; Bojarczuk, K; Chlebowska, J; Dwojak, M; Firczuk, M; Glodkowska-Mrowka, E; Golab, J; Miaczynska, M; Muchowicz, A; Nowis, D; Roszczenko, K; Wachowska, M; Wanczyk, M; Wilczek, E; Winiarska, M | 1 |
42 other study(ies) available for methionine and l 744832
| Article | Year |
|---|---|
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genes, ras; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Transgenic; Salivary Gland Neoplasms; Transferases | 1995 |
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Cycle; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Methionine; Mice; Mice, Transgenic; Salivary Gland Neoplasms | 1998 |
Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Fragmentation; Drug Synergism; Enzyme Inhibitors; Epothilones; Farnesyltranstransferase; Humans; Methionine; Mitosis; Paclitaxel; Thiazoles; Tumor Cells, Cultured | 1998 |
Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Lymphoma; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Transgenic; Protein Processing, Post-Translational; Proto-Oncogene Mas; Proto-Oncogene Proteins p21(ras) | 1998 |
A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; G1 Phase; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Methionine; Mitosis; Phosphorylation; Proto-Oncogene Proteins p21(ras); Retinoblastoma Protein; Tumor Cells, Cultured; Up-Regulation | 1998 |
Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis.
Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Farnesyltranstransferase; Female; G1 Phase; Growth Inhibitors; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Transgenic; Receptor, ErbB-2; Transforming Growth Factor alpha | 1999 |
Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
Topics: Adaptor Proteins, Signal Transducing; Alkyl and Aryl Transferases; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cell Line; DNA Replication; Enzyme Inhibitors; Eukaryotic Initiation Factors; Farnesyltranstransferase; Keratinocytes; Methionine; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphoproteins; Phosphorylation; ras Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tumor Cells, Cultured | 1999 |
Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.
Topics: 3T3 Cells; Actins; Alkyl and Aryl Transferases; Animals; Apoptosis; Cell Adhesion; Cell Division; Cell Line, Transformed; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Farnesyltranstransferase; Growth Inhibitors; GTP-Binding Proteins; Membrane Proteins; Methionine; Mice; Protein Prenylation; ras Proteins; Rats; Recombinant Fusion Proteins; rhoB GTP-Binding Protein | 1999 |
In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Crosses, Genetic; Farnesyltranstransferase; Female; Genes, Tumor Suppressor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Leukemia, Myeloid; Leukocyte Count; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neurofibromin 1; Protein Prenylation; Proteins; ras Proteins | 1999 |
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.
Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Astrocytoma; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bromodeoxyuridine; Cell Cycle; Cell Division; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Farnesyltranstransferase; Genes, ras; Growth Inhibitors; Humans; Lymphokines; Membrane Proteins; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Neovascularization, Pathologic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors.
Topics: Adult; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cells, Cultured; Child; Colony-Forming Units Assay; Enzyme Inhibitors; Farnesyltranstransferase; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Humans; Leukemia, Myelomonocytic, Chronic; Leukocytes, Mononuclear; Macrophages; Methionine; Mice; Mice, Mutant Strains; Oligopeptides; Protein Prenylation; Tumor Cells, Cultured | 2000 |
The farnesyltransferase inhibitor L-744,832 inhibits the growth of astrocytomas through a combination of antiproliferative, antiangiogenic, and proapoptotic activities.
Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Astrocytoma; Brain Neoplasms; Cell Division; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methionine | 1999 |
Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.
Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Keratinocytes; Marine Toxins; Methionine; Mice; Oxazoles; Phosphorylation; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 2000 |
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Disease Models, Animal; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Growth Inhibitors; Humans; Mammary Neoplasms, Animal; Mammary Tumor Virus, Mouse; Methionine; Mice; Mice, Transgenic; Phenotype; Transgenes | 2000 |
A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Growth Inhibitors; Humans; Male; Methionine; Mice; Mice, Nude; Models, Chemical; Molecular Mimicry; Neoplasm Transplantation; Paclitaxel; Prostatic Neoplasms; ras Proteins; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
Topics: Alkyl and Aryl Transferases; Animals; Colonic Neoplasms; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Methionine; Mice; Mice, Nude; Neoplasm Recurrence, Local; Neoplasm Transplantation; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tumor Stem Cell Assay; Urinary Bladder Neoplasms | 2000 |
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Contact Inhibition; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation; Genes, jun; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; NF-kappa B; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphatidylinositol 3-Kinases; Protein Prenylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Receptors, Eph Family; rhoA GTP-Binding Protein; Serum Response Factor; Signal Transduction; Tumor Stem Cell Assay | 2000 |
The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Cell Hypoxia; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression; Genes, ras; HT29 Cells; Humans; Methionine; Mice; Mice, Nude; Mutation; Neoplasms; Oxygen; ras Proteins; Xenograft Model Antitumor Assays | 2001 |
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
Topics: Adenocarcinoma; Alkyl and Aryl Transferases; Apoptosis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Induction; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Methionine; Neoplasm Proteins; Pancreatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Radiation Tolerance; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Signal Transduction; Transforming Growth Factor beta | 2002 |
Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor.
Topics: Alkyl and Aryl Transferases; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Division; Cell Line, Transformed; Cell Movement; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methionine; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Phalloidine; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; rhoC GTP-Binding Protein; Rhodamines; Transfection; Tumor Cells, Cultured | 2002 |
Farnesyl protein transferase inhibition interferes with activation of MAP kinase family members in human peripheral blood monocytes.
Topics: Alkyl and Aryl Transferases; Drug Antagonism; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Humans; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Signal Transduction | 2002 |
Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors.
Topics: Actin Cytoskeleton; Actins; Alkyl and Aryl Transferases; Animals; Bacterial Proteins; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; Epithelial Cells; Escherichia coli Proteins; Farnesyltranstransferase; Fibroblasts; Genes, ras; Intestinal Mucosa; Methionine; Models, Biological; Protein Isoforms; Protein Kinase C; Protein Prenylation; Protein Processing, Post-Translational; rac1 GTP-Binding Protein; Rats; Signal Transduction | 2003 |
Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1.
Topics: Actins; Adaptor Proteins, Signal Transducing; Adenovirus E1A Proteins; Alkyl and Aryl Transferases; Animals; Antigens, Polyomavirus Transforming; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Inhibitors; Farnesyltranstransferase; Fibroblasts; Gene Deletion; Membrane Proteins; Methionine; Mice; Mice, SCID; Nerve Tissue Proteins; Nuclear Proteins; ras Proteins; rhoB GTP-Binding Protein; Stress, Physiological; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2003 |
Constitutive NF-kappaB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway.
Topics: Acute Disease; Apoptosis; Chromones; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Genes, Reporter; Growth Substances; Humans; Leukemia, Myeloid; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutation; NF-kappa B; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2004 |
Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Butyrates; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Drug Therapy, Combination; Farnesyltranstransferase; Humans; Methionine; Neoplasms; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2004 |
Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival.
Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Xenograft Model Antitumor Assays | 2005 |
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
Topics: Acute Disease; Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia, Myeloid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potentials; Methionine; Mitochondria; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine; U937 Cells | 2005 |
Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor.
Topics: Alkyl and Aryl Transferases; Aluminum Compounds; Blotting, Western; Cell Fractionation; Cloning, Molecular; Farnesyltranstransferase; Fluorescent Antibody Technique; Fluorides; Genetic Vectors; Golgi Apparatus; GTP-Binding Proteins; Guanosine Triphosphate; HeLa Cells; Humans; Immunoprecipitation; Interferon-gamma; Methionine; Mutagenesis; Mutation; Protein Prenylation; Protein Transport; Retroviridae; Transduction, Genetic | 2005 |
The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cytochromes c; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Farnesyltranstransferase; Glycogen Synthase Kinase 3; Humans; JNK Mitogen-Activated Protein Kinases; Methionine; Multiple Myeloma; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; STAT3 Transcription Factor; Staurosporine; Trans-Activators | 2005 |
Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Farnesyltranstransferase; Fluorouracil; Humans; Methionine; Radiation Tolerance | 2005 |
Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery.
Topics: Angioplasty, Balloon, Coronary; Animals; Azulenes; Calcimycin; Coronary Vessels; Fucose; Growth Inhibitors; Male; Methionine; Models, Animal; Serotonin; Sirolimus; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
Topics: Antibodies, Monoclonal; Blotting, Western; CD28 Antigens; CD3 Complex; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HSP40 Heat-Shock Proteins; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; MAP Kinase Kinase 4; Methionine; Phosphorylation; Piperidines; Protein Prenylation; Pyridines; Quinolones; Ribonuclease, Pancreatic; Ribosomal Protein S6 Kinases, 70-kDa; RNA Processing, Post-Transcriptional; T-Lymphocytes; Th1 Cells; Th2 Cells | 2007 |
A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L-744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapy.
Topics: Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cisplatin; Drug Synergism; Drug Therapy, Combination; Female; HeLa Cells; Humans; Methionine; Proto-Oncogene Proteins p21(ras); Uterine Cervical Neoplasms | 2008 |
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing | 2008 |
Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.
Topics: Adolescent; Aged, 80 and over; Apoptosis; Cell Movement; Cell Nucleus; Cell Survival; Cells, Cultured; Child; Child, Preschool; Dose-Response Relationship, Drug; Farnesyltranstransferase; Female; Fibroblasts; Humans; Male; Methionine; Nuclear Proteins; Progeria; Sensitivity and Specificity; Skin; Wound Healing | 2008 |
Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; Lymphocytes; Lymphoma, B-Cell; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Pyridines; Remission Induction | 2008 |
Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway.
Topics: Acute Kidney Injury; Animals; Apolipoproteins E; Cholesterol; Creatinine; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Kidney; Male; Methionine; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Pravastatin; Reperfusion Injury; Terpenes | 2008 |
Combining an FPTase inhibitor with cisplatin facilitates induction of apoptosis in human A549 lung cancer cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle; Cell Proliferation; Cisplatin; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Humans; Immunoblotting; Lung Neoplasms; Methionine; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2011 |
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
Topics: Antifungal Agents; Candida albicans; Clozapine; Gene Expression Regulation, Fungal; Hyphae; Methionine; Signal Transduction | 2011 |
Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation.
Topics: Animals; Antifungal Agents; Blotting, Western; Cell Line; Cell Proliferation; Cholesterol; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Liver; Methionine; Mice; Prenylation; ras Proteins; Triazoles | 2012 |
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.
Topics: Aging; Animals; Behavior, Animal; Benzamides; Cardiovascular Diseases; Drosophila melanogaster; Feeding Behavior; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longevity; Male; Methionine; Mice; Simvastatin; Ubiquinone | 2012 |
Prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity.
Topics: Antibodies, Monoclonal; Antigens, CD20; Cell Line, Tumor; Chromatin Immunoprecipitation; Complement System Proteins; Dimethylallyltranstransferase; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Lymphoma, B-Cell; Methionine; Promoter Regions, Genetic | 2012 |