Page last updated: 2024-08-17

methionine and l 744832

methionine has been researched along with l 744832 in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (26.19)18.2507
2000's26 (61.90)29.6817
2010's5 (11.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anthony, NJ; Conner, MW; Davide, JP; deSolms, SJ; Giuliani, EA; Gomez, RP; Graham, SL; Hamilton, K; Kohl, NE; Omer, CA1
Barrington, RE; Bearss, DJ; Conner, MW; Gibbs, JB; Hamilton, K; Hundley, JE; Koblan, KS; Koester, SK; Kohl, NE; Miller, PJ; Mosser, SD; O'Neill, TJ; Oliff, A; Omer, CA; Rands, E; Schaber, MD; Senderak, ET; Subler, MA; Troyer, DA; Windle, JJ1
Balog, A; Danishefsky, SJ; Kohl, NE; Moasser, MM; Oliff, A; Rosen, N; Sepp-Lorenzino, L; Su, DS1
Corral, T; Gibbs, JB; Kohl, NE; Lu, S; Malumbres, M; Mangues, R; Oliff, A; Pellicer, A; Symmans, WF1
Rosen, N; Sepp-Lorenzino, L1
Coffey, RJ; Joseph, H; Kohl, NE; Law, B; Mays, D; Moses, HL; Nørgaard, P; Oliff, A; Page, DL; Pietenpol, JA; Poulsen, HS; Shyr, Y1
Gnudi, L; Kahn, BB; Law, BK; Moses, HL; Nørgaard, P; Poulson, HS1
Du, W; Lebowitz, PF; Prendergast, GC1
Gibbs, JB; Gratiot, M; Jacks, T; Kohl, NE; Mahgoub, N; Shannon, KM; Taylor, BR1
Feldkamp, MM; Guha, A; Lau, N2
Castleberry, RP; Emanuel, PD; Gopurala, B; Snyder, RC; Wiley, T1
Law, BK; Moses, HL; Norgaard, P1
Abrams, MT; Bhimnathwala, H; Chen, HY; Chen, Z; Conner, MW; Davide, JP; Diehl, RE; Ellis, MS; Gibbs, JB; Gopal-Truter, S; Greenberg, I; Koblan, KS; Kohl, NE; Kral, AM; Liu, D; Lobell, RB; Miller, PJ; Mosser, SD; O'Neill, TJ; Oliff, A; Omer, CA; Rands, E; Schaber, MD; Seeburger, G; Senderak, ET; Trumbauer, ME1
Kohl, NE; Rosen, N; Scher, HI; Sepp-Lorenzino, L; Sirotnak, FM1
Bernhard, EJ; Cerniglia, G; Cohen-Jonathan, E; Evans, SM; Gibbs, JB; Gillies McKenna, W; Hamilton, AD; Kohl, N; Kusewitt, D; Mick, R; Muschel, RJ; Oliff, A; Sebti, SM1
Andres, DA; Chan, TO; Cox, AD; Grana, TM; Reynolds, ER; Rusyn, EV; Shao, H1
Bernhard, EJ; Cohen-Jonathan, E; Evans, SM; Koch, CJ; McKenna, WG; Muschel, RJ; Wu, J1
Ahmed, MM; Alcock, RA; Chatfield, LK; Chendil, D; Dey, S; Gallicchio, VS; Hartman, G; Inayat, MS; Mohiuddin, M1
Bao, L; DiVito, MM; Merajver, SD; Prendergast, GC; van Golen, KL; Wu, Z1
Bos, CL; Peppelenbosch, MP; Rens, LS; Richel, DJ; Vervenne, WL1
Chintapalli, J; Du, W; Prendergast, GC; Rane, N; Zeng, PY1
Baker, J; Donover, S; Du, W; DuHadaway, JB; Liu, AX; Muller, AJ; Prendergast, GC; Sharp, DM1
Birkenkamp, KU; Geugien, M; Lemmink, HH; Schepers, H; Vellenga, E; Westra, J1
Golab, J; Jakobisiak, M; Kopec, M; Legat, M; Makowski, M; Strusinska, K1
Bernhard, EJ; Cerniglia, GJ; Cohen-Jonathan, E; Koch, CJ; Mick, R; Rhim, JS; Shi, Y; Wu, J1
Dai, Y; Dent, P; Grant, S; Han, SI; Khanna, P; Mitchell, C; Pei, XY; Rahmani, M1
Cresswell, P; Lu, YE; Modiano, N1
Dai, Y; Dent, P; Grant, S; Li, W; Pei, XY; Rahmani, M1
Aydin, F; Kavgaci, H; Ovali, E; Ozdemir, F; Yavuz, A; Yavuz, M1
Kennedy, S; Wadsworth, RM; Wainwright, CL1
Berk, S; Gajewski, TF; Ho, AW; Kuna, T; Marks, RE; Robbel, C1
Kramer, MP; Schmid, G; Wesierska-Gadek, J1
Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1
Cummings, KS; Ji, JY; Lammerding, J; Lee, RT; Verstraeten, VL1
Bishop, JM; Charoenthongtrakul, S; Field, KA; Refaeli, Y1
Burne-Taney, MJ; Ikeda, M; Ito, K; Kumagai, K; Mori, M; Rabb, H; Sharyo, S; Uchida, K; Yokota-Ikeda, N1
Hackl, S; Kramer, M; Siska, P; Weber, F; Wesierska-Gádek, J; Zulehner, N1
Borochoff-Porte, N; Johnson, DI; Midkiff, J; White, D1
Moore, T; Murphy, LA; Nesnow, S1
Ablao, KP; Bodmer, R; Dhahbi, JM; Li, R; Mote, P; Ocorr, K; Spindler, SR; Wang, Y; Williams, RT; Yamakawa, A1
Basak, GW; Bil, J; Bojarczuk, K; Chlebowska, J; Dwojak, M; Firczuk, M; Glodkowska-Mrowka, E; Golab, J; Miaczynska, M; Muchowicz, A; Nowis, D; Roszczenko, K; Wachowska, M; Wanczyk, M; Wilczek, E; Winiarska, M1

Other Studies

42 other study(ies) available for methionine and l 744832

ArticleYear
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice.
    Nature medicine, 1995, Volume: 1, Issue:8

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genes, ras; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Transgenic; Salivary Gland Neoplasms; Transferases

1995
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
    Molecular and cellular biology, 1998, Volume: 18, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Cycle; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Methionine; Mice; Mice, Transgenic; Salivary Gland Neoplasms

1998
Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Feb-17, Volume: 95, Issue:4

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Cell Cycle; DNA Fragmentation; Drug Synergism; Enzyme Inhibitors; Epothilones; Farnesyltranstransferase; Humans; Methionine; Mitosis; Paclitaxel; Thiazoles; Tumor Cells, Cultured

1998
Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice.
    Cancer research, 1998, Mar-15, Volume: 58, Issue:6

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Lymphoma; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Transgenic; Protein Processing, Post-Translational; Proto-Oncogene Mas; Proto-Oncogene Proteins p21(ras)

1998
A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells.
    The Journal of biological chemistry, 1998, Aug-07, Volume: 273, Issue:32

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Cyclin-Dependent Kinases; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; G1 Phase; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Methionine; Mitosis; Phosphorylation; Proto-Oncogene Proteins p21(ras); Retinoblastoma Protein; Tumor Cells, Cultured; Up-Regulation

1998
Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Farnesyltranstransferase; Female; G1 Phase; Growth Inhibitors; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Transgenic; Receptor, ErbB-2; Transforming Growth Factor alpha

1999
Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
    The Journal of biological chemistry, 1999, Feb-19, Volume: 274, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Alkyl and Aryl Transferases; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cell Line; DNA Replication; Enzyme Inhibitors; Eukaryotic Initiation Factors; Farnesyltranstransferase; Keratinocytes; Methionine; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphoproteins; Phosphorylation; ras Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tumor Cells, Cultured

1999
Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.
    Molecular and cellular biology, 1999, Volume: 19, Issue:3

    Topics: 3T3 Cells; Actins; Alkyl and Aryl Transferases; Animals; Apoptosis; Cell Adhesion; Cell Division; Cell Line, Transformed; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Farnesyltranstransferase; Growth Inhibitors; GTP-Binding Proteins; Membrane Proteins; Methionine; Mice; Protein Prenylation; ras Proteins; Rats; Recombinant Fusion Proteins; rhoB GTP-Binding Protein

1999
In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells.
    Blood, 1999, Oct-01, Volume: 94, Issue:7

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Crosses, Genetic; Farnesyltranstransferase; Female; Genes, Tumor Suppressor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Leukemia, Myeloid; Leukocyte Count; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neurofibromin 1; Protein Prenylation; Proteins; ras Proteins

1999
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.
    Oncogene, 1999, Dec-09, Volume: 18, Issue:52

    Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Astrocytoma; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bromodeoxyuridine; Cell Cycle; Cell Division; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Farnesyltranstransferase; Genes, ras; Growth Inhibitors; Humans; Lymphokines; Membrane Proteins; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Neovascularization, Pathologic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1999
Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyltransferase inhibitors.
    Blood, 2000, Jan-15, Volume: 95, Issue:2

    Topics: Adult; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cells, Cultured; Child; Colony-Forming Units Assay; Enzyme Inhibitors; Farnesyltranstransferase; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Humans; Leukemia, Myelomonocytic, Chronic; Leukocytes, Mononuclear; Macrophages; Methionine; Mice; Mice, Mutant Strains; Oligopeptides; Protein Prenylation; Tumor Cells, Cultured

2000
The farnesyltransferase inhibitor L-744,832 inhibits the growth of astrocytomas through a combination of antiproliferative, antiangiogenic, and proapoptotic activities.
    Annals of the New York Academy of Sciences, 1999, Volume: 886

    Topics: Alkyl and Aryl Transferases; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Astrocytoma; Brain Neoplasms; Cell Division; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methionine

1999
Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.
    The Journal of biological chemistry, 2000, Apr-14, Volume: 275, Issue:15

    Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Keratinocytes; Marine Toxins; Methionine; Mice; Oxazoles; Phosphorylation; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate

2000
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
    Cancer research, 2000, May-15, Volume: 60, Issue:10

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Disease Models, Animal; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Growth Inhibitors; Humans; Mammary Neoplasms, Animal; Mammary Tumor Virus, Mouse; Methionine; Mice; Mice, Transgenic; Phenotype; Transgenes

2000
A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility.
    Cancer chemotherapy and pharmacology, 2000, Volume: 46, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Growth Inhibitors; Humans; Male; Methionine; Mice; Mice, Nude; Models, Chemical; Molecular Mimicry; Neoplasm Transplantation; Paclitaxel; Prostatic Neoplasms; ras Proteins; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS.
    Radiation research, 2000, Volume: 154, Issue:2

    Topics: Alkyl and Aryl Transferases; Animals; Colonic Neoplasms; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Methionine; Mice; Mice, Nude; Neoplasm Recurrence, Local; Neoplasm Transplantation; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tumor Stem Cell Assay; Urinary Bladder Neoplasms

2000
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
    Oncogene, 2000, Sep-28, Volume: 19, Issue:41

    Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Contact Inhibition; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation; Genes, jun; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; NF-kappa B; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphatidylinositol 3-Kinases; Protein Prenylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Receptors, Eph Family; rhoA GTP-Binding Protein; Serum Response Factor; Signal Transduction; Tumor Stem Cell Assay

2000
The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
    Cancer research, 2001, Mar-01, Volume: 61, Issue:5

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Cell Hypoxia; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression; Genes, ras; HT29 Cells; Humans; Methionine; Mice; Mice, Nude; Mutation; Neoplasms; Oxygen; ras Proteins; Xenograft Model Antitumor Assays

2001
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
    Oncogene, 2002, Nov-07, Volume: 21, Issue:51

    Topics: Adenocarcinoma; Alkyl and Aryl Transferases; Apoptosis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Induction; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Methionine; Neoplasm Proteins; Pancreatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Radiation Tolerance; Radiation-Sensitizing Agents; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Signal Transduction; Transforming Growth Factor beta

2002
Reversion of RhoC GTPase-induced inflammatory breast cancer phenotype by treatment with a farnesyl transferase inhibitor.
    Molecular cancer therapeutics, 2002, Volume: 1, Issue:8

    Topics: Alkyl and Aryl Transferases; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Division; Cell Line, Transformed; Cell Movement; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methionine; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Phalloidine; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; rhoC GTP-Binding Protein; Rhodamines; Transfection; Tumor Cells, Cultured

2002
Farnesyl protein transferase inhibition interferes with activation of MAP kinase family members in human peripheral blood monocytes.
    Molecular medicine (Cambridge, Mass.), 2002, Volume: 8, Issue:12

    Topics: Alkyl and Aryl Transferases; Drug Antagonism; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Humans; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Signal Transduction

2002
Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors.
    Oncogene, 2003, Feb-27, Volume: 22, Issue:8

    Topics: Actin Cytoskeleton; Actins; Alkyl and Aryl Transferases; Animals; Bacterial Proteins; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; Epithelial Cells; Escherichia coli Proteins; Farnesyltranstransferase; Fibroblasts; Genes, ras; Intestinal Mucosa; Methionine; Models, Biological; Protein Isoforms; Protein Kinase C; Protein Prenylation; Protein Processing, Post-Translational; rac1 GTP-Binding Protein; Rats; Signal Transduction

2003
Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1.
    Oncogene, 2003, Jun-05, Volume: 22, Issue:23

    Topics: Actins; Adaptor Proteins, Signal Transducing; Adenovirus E1A Proteins; Alkyl and Aryl Transferases; Animals; Antigens, Polyomavirus Transforming; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Inhibitors; Farnesyltranstransferase; Fibroblasts; Gene Deletion; Membrane Proteins; Methionine; Mice; Mice, SCID; Nerve Tissue Proteins; Nuclear Proteins; ras Proteins; rhoB GTP-Binding Protein; Stress, Physiological; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2003
Constitutive NF-kappaB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway.
    Leukemia, 2004, Volume: 18, Issue:1

    Topics: Acute Disease; Apoptosis; Chromones; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Genes, Reporter; Growth Substances; Humans; Leukemia, Myeloid; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Mutation; NF-kappa B; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured

2004
Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro.
    Oncology reports, 2004, Volume: 11, Issue:5

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Butyrates; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Drug Therapy, Combination; Farnesyltranstransferase; Humans; Methionine; Neoplasms; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2004
Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival.
    The Prostate, 2005, Jan-01, Volume: 62, Issue:1

    Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Xenograft Model Antitumor Assays

2005
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
    Blood, 2005, Feb-15, Volume: 105, Issue:4

    Topics: Acute Disease; Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HL-60 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia, Myeloid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potentials; Methionine; Mitochondria; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Staurosporine; U937 Cells

2005
Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Jun-14, Volume: 102, Issue:24

    Topics: Alkyl and Aryl Transferases; Aluminum Compounds; Blotting, Western; Cell Fractionation; Cloning, Molecular; Farnesyltranstransferase; Fluorescent Antibody Technique; Fluorides; Genetic Vectors; Golgi Apparatus; GTP-Binding Proteins; Guanosine Triphosphate; HeLa Cells; Humans; Immunoprecipitation; Interferon-gamma; Methionine; Mutagenesis; Mutation; Protein Prenylation; Protein Transport; Retroviridae; Transduction, Genetic

2005
The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jun-15, Volume: 11, Issue:12

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Blotting, Western; CDC2 Protein Kinase; Cell Line, Tumor; Cytochromes c; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Farnesyltranstransferase; Glycogen Synthase Kinase 3; Humans; JNK Mitogen-Activated Protein Kinases; Methionine; Multiple Myeloma; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; STAT3 Transcription Factor; Staurosporine; Trans-Activators

2005
Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU.
    Chemotherapy, 2005, Volume: 51, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Farnesyltranstransferase; Fluorouracil; Humans; Methionine; Radiation Tolerance

2005
Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery.
    Vascular pharmacology, 2006, Volume: 44, Issue:5

    Topics: Angioplasty, Balloon, Coronary; Animals; Azulenes; Calcimycin; Coronary Vessels; Fucose; Growth Inhibitors; Male; Methionine; Models, Animal; Serotonin; Sirolimus; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2006
Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
    Blood, 2007, Sep-15, Volume: 110, Issue:6

    Topics: Antibodies, Monoclonal; Blotting, Western; CD28 Antigens; CD3 Complex; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HSP40 Heat-Shock Proteins; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; MAP Kinase Kinase 4; Methionine; Phosphorylation; Piperidines; Protein Prenylation; Pyridines; Quinolones; Ribonuclease, Pancreatic; Ribosomal Protein S6 Kinases, 70-kDa; RNA Processing, Post-Transcriptional; T-Lymphocytes; Th1 Cells; Th2 Cells

2007
A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L-744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapy.
    Journal of cellular biochemistry, 2008, May-01, Volume: 104, Issue:1

    Topics: Alkyl and Aryl Transferases; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cisplatin; Drug Synergism; Drug Therapy, Combination; Female; HeLa Cells; Humans; Methionine; Proto-Oncogene Proteins p21(ras); Uterine Cervical Neoplasms

2008
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
    Molecular pharmacology, 2008, Volume: 73, Issue:5

    Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing

2008
Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.
    Aging cell, 2008, Volume: 7, Issue:3

    Topics: Adolescent; Aged, 80 and over; Apoptosis; Cell Movement; Cell Nucleus; Cell Survival; Cells, Cultured; Child; Child, Preschool; Dose-Response Relationship, Drug; Farnesyltranstransferase; Female; Fibroblasts; Humans; Male; Methionine; Nuclear Proteins; Progeria; Sensitivity and Specificity; Skin; Wound Healing

2008
Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas.
    Molecular cancer, 2008, May-19, Volume: 7

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; Lymphocytes; Lymphoma, B-Cell; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Pyridines; Remission Induction

2008
Pravastatin improves renal ischemia-reperfusion injury by inhibiting the mevalonate pathway.
    Kidney international, 2008, Volume: 74, Issue:5

    Topics: Acute Kidney Injury; Animals; Apolipoproteins E; Cholesterol; Creatinine; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Kidney; Male; Methionine; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Pravastatin; Reperfusion Injury; Terpenes

2008
Combining an FPTase inhibitor with cisplatin facilitates induction of apoptosis in human A549 lung cancer cells.
    Journal of experimental therapeutics & oncology, 2011, Volume: 9, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Alkyl and Aryl Transferases; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle; Cell Proliferation; Cisplatin; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Humans; Immunoblotting; Lung Neoplasms; Methionine; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2011
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Antifungal Agents; Candida albicans; Clozapine; Gene Expression Regulation, Fungal; Hyphae; Methionine; Signal Transduction

2011
Propiconazole-enhanced hepatic cell proliferation is associated with dysregulation of the cholesterol biosynthesis pathway leading to activation of Erk1/2 through Ras farnesylation.
    Toxicology and applied pharmacology, 2012, Apr-15, Volume: 260, Issue:2

    Topics: Animals; Antifungal Agents; Blotting, Western; Cell Line; Cell Proliferation; Cholesterol; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Liver; Methionine; Mice; Prenylation; ras Proteins; Triazoles

2012
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Aging; Animals; Behavior, Animal; Benzamides; Cardiovascular Diseases; Drosophila melanogaster; Feeding Behavior; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longevity; Male; Methionine; Mice; Simvastatin; Ubiquinone

2012
Prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity.
    The Journal of biological chemistry, 2012, Sep-14, Volume: 287, Issue:38

    Topics: Antibodies, Monoclonal; Antigens, CD20; Cell Line, Tumor; Chromatin Immunoprecipitation; Complement System Proteins; Dimethylallyltranstransferase; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Lymphoma, B-Cell; Methionine; Promoter Regions, Genetic

2012