methionine has been researched along with ggti 298 in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (27.03) | 18.2507 |
| 2000's | 20 (54.05) | 29.6817 |
| 2010's | 7 (18.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 1 |
| Blaskovich, MA; Davies, P; Finder, JD; Hamilton, AD; Litz, JL; McGuire, TF; Qian, Y; Sebti, SM | 1 |
| Favre, G; Hamilton, AD; Miquel, K; Pradines, A; Qian, Y; Sebti, SM; Sun, J | 1 |
| Hamilton, AD; Knowles, DB; Lerner, EC; Qian, Y; Sebti, SM; Zhang, TT | 1 |
| Hamilton, AD; Qian, Y; Sebti, SM; Sun, J; Vogt, A | 1 |
| Bredel, M; Freund, JM; Hamilton, AD; Pollack, IF; Sebti, SM | 1 |
| Blaskovich, MA; Davies, P; Hamilton, AD; Johnson, BA; Pitt, B; Qian, Y; Sebti, SM; Stark, WW; Vasudevan, A | 1 |
| Abrams, WR; Blaskovich, MA; Hamilton, AD; Kucich, U; Ohkanda, J; Rosenbloom, J; Rosenbloom, JC; Sebti, SM; Shen, G | 1 |
| Bifulco, M; Di Matola, T; Fenzi, G; Laezza, C; Rossi, G; Vitale, M | 1 |
| Bailey, R; Hamilton, AD; Harlan, JM; Kovach, NL; Liu, L; Moesner, P; Sebti, SM | 1 |
| Blaskovich, MA; Boota, A; Davies, P; Hamilton, A; Johnson, B; Kagan, VE; Lee, KL; Liu, SX; Pitt, B; Sebti, SM | 1 |
| Coxon, FP; Hamilton, A; Helfrich, MH; Ralston, SH; Rogers, MJ; Sebti, S; Van't Hof, R | 1 |
| Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z | 1 |
| Chaqour, B; Macarak, E; Rosenbloom, J; Tamura, I | 1 |
| Bannerman, DD; Hamilton, AD; Harlan, JM; Li, X; Liu, L; Sebti, SM; Tupper, JC; Winn, RK | 1 |
| Adamson, P; Baker, D; Greenwood, J; Hamilton, AD; Hankey, DJR; Pryce, G; Sebti, SM; Walters, CE | 1 |
| Balaguer, P; Carroll, JS; Cestac, P; Chouini, S; Doisneau-Sixou, SF; Favre, G; Faye, JC; Hamilton, AD; Poirot, M; Sebti, SM; Sutherland, RL | 1 |
| Inoue, M; Kusama, T; Matsumoto, Y; Mukai, M; Nakamura, H; Tatsuta, M | 1 |
| Balaguer, P; Cestac, P; Doisneau-Sixou, S; Favre, G; Faye, JC; Médale-Giamarchi, C; Rochaix, P; Sarrabayrouse, G | 1 |
| Efuet, ET; Keyomarsi, K | 1 |
| Inoue, M; Kusama, T; Mukai, M; Nakamura, H; Tatsuta, M | 1 |
| Adnane, J; Bizouarn, F; Blaskovich, MA; Chellappan, S; Delarue, FL; Hamilton, AD; Hawker, J; Joshi, B; Ohkanda, J; Sebti, SM; Wang, DA; Zhu, K | 1 |
| Engert, A; Hansen, HP; Sasse, S; Tawadros, S; von Strandmann, EP; von Tresckow, B | 1 |
| Abeles, AM; Abramson, SB; Al-Mussawir, H; Al-Mussawir, HE; Attur, M; Chan, ES; Dave, M; Fisher, MC; Marjanovic, N; Park, J; Pillinger, MH; Stuchin, SA | 1 |
| Beck, JF; Bumbul, B; Sonnemann, J | 1 |
| Favre, G; Leveque, K; Sarrabayrouse, G; Synaeve, C; Tilkin-Mariamé, AF | 1 |
| Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I | 1 |
| Amet, T; Arai, A; Miura, O; Nonaka, M; Saitoh, Y; Sugimoto, H; Takahashi, M; Uota, S; Yamamoto, N; Yamaoka, S | 1 |
| Horiuchi, N; Maeda, T | 1 |
| Hirose, K; Ikeda, K; Iwamoto, I; Kagami, S; Kanari, H; Nakajima, H; Owada, T; Saito, Y; Suto, A; Watanabe, N | 1 |
| Härkönen, PL; Kalervo Väänänen, H; Sandholm, J; Virtanen, SS; Yegutkin, G | 1 |
| Huang, L; Kumta, SM; Lau, CP; Leung, PY; Ng, PK; Tsui, SK | 1 |
| Duque, G; Rivas, D; Vidal, C | 1 |
| Ageberg, M; Drott, K; Jerkeman, M; Lindén, O; Linderoth, J; Rydström, K | 1 |
| Aránguiz, P; Canales, J; Catalán, M; Chiong, M; Copaja, M; Díaz-Araya, G; Lavandero, S; Leyton, L; Olmedo, I; Rodríguez, AE; Venegas, D; Vivar, R | 1 |
| Ablao, KP; Bodmer, R; Dhahbi, JM; Li, R; Mote, P; Ocorr, K; Spindler, SR; Wang, Y; Williams, RT; Yamakawa, A | 1 |
| Chu, UB; Duellman, T; Tao, Y; Weaver, SJ; Yang, J | 1 |
37 other study(ies) available for methionine and ggti 298
| Article | Year |
|---|---|
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
Topics: Alkyl and Aryl Transferases; Animals; Benzamides; Enzyme Induction; Enzyme Inhibitors; Farnesyltranstransferase; GTP-Binding Proteins; Interleukin-1; Liver; Male; Methionine; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitrites; Protein Prenylation; Proto-Oncogene Proteins; rap GTP-Binding Proteins; ras Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factors; Transferases | 1997 |
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
Topics: Adenocarcinoma; Alkyl and Aryl Transferases; Apoptosis; Benzamides; Cell Division; Enzyme Inhibitors; G1 Phase; G2 Phase; Humans; Lung Neoplasms; Methionine; Mitosis; Resting Phase, Cell Cycle; Transferases; Tumor Cells, Cultured | 1997 |
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Topics: Alkyl and Aryl Transferases; Benzamides; Cell Division; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; GTP-Binding Proteins; Humans; Methionine; Peptides; Protein Prenylation; rap GTP-Binding Proteins; ras Proteins; Tumor Cells, Cultured | 1997 |
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
Topics: Alkyl and Aryl Transferases; Benzamides; Breast Neoplasms; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Female; Fibrosarcoma; G1 Phase; Head and Neck Neoplasms; Humans; Lovastatin; Methionine; Oligopeptides; Pancreatic Neoplasms; Protein Prenylation; Resting Phase, Cell Cycle; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 1997 |
Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth.
Topics: Benzamides; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; GTP-Binding Proteins; Humans; Methionine; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Tumor Cells, Cultured; Tumor Stem Cell Assay | 1998 |
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Benzamides; Cell Division; Cells, Cultured; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; GTP-Binding Proteins; Kinetics; Lovastatin; Methionine; Microcirculation; Muscle, Smooth, Vascular; Protein Prenylation; Pulmonary Artery; rap GTP-Binding Proteins; ras Proteins; Rats; Transcription Factors | 1998 |
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Topics: Acyltransferases; Alkyl and Aryl Transferases; Benzamides; Cell Line; Cholera Toxin; Elastin; Enzyme Inhibitors; Fibroblasts; GTP Phosphohydrolases; Humans; Lung; Methionine; Protein Kinase C; Protein Prenylation; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta; Tropoelastin; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism.
Topics: Apoptosis; Benzamides; Caspases; Cell Division; Cell Line; Cysteine Proteinase Inhibitors; Dimethylallyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Methionine; Serpins; Thyroid Gland; Tumor Suppressor Protein p53; Viral Proteins | 1999 |
Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s).
Topics: Benzamides; Cell Adhesion; Diterpenes; Fibronectins; Humans; Integrins; Jurkat Cells; Leukocytes; Lovastatin; Methionine; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; U937 Cells | 1999 |
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.
Topics: Animals; Benzamides; Cells, Cultured; Dimethylallyltranstransferase; Enzyme Inhibitors; Genes, ras; Interleukin-1; Male; Methionine; Muscle, Smooth, Vascular; Mutation; Platelet-Derived Growth Factor; Pulmonary Circulation; Rats; Superoxides; Transfection | 2000 |
Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.
Topics: Animals; Apoptosis; Benzamides; Bone Resorption; Cell Differentiation; Cell Survival; Cells, Cultured; Chick Embryo; Cytoskeleton; Diphosphonates; Enzyme Inhibitors; Methionine; Mice; Osteoclasts; Protein Prenylation; Rabbits | 2000 |
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
Topics: Acute Disease; Apoptosis; Benzamides; Deoxyuracil Nucleotides; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Tumor Cells, Cultured | 2001 |
Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.
Topics: Animals; Benzamides; Blotting, Northern; Cattle; Cells, Cultured; DNA Probes; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; In Situ Hybridization; Methionine; Muscle Spindles; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Physical Stimulation; Signal Transduction | 2001 |
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
Topics: Apoptosis; Benzamides; Caspase 3; Caspases; Cell Death; Cells, Cultured; Diterpenes; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Lovastatin; Methionine; Polyisoprenyl Phosphates; Protein Prenylation; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Umbilical Veins | 2002 |
Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.
Topics: Acute Disease; Animals; Benzamides; Brain; Cell Line; Cell Membrane; Cell Movement; Dimethylallyltranstransferase; Disease Models, Animal; Drug Combinations; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Guinea Pigs; Leukocytes; Methionine; Mice; Mice, Inbred Strains; Multiple Sclerosis; Myelin Basic Protein; Protein Prenylation; Rats; Rats, Inbred Lew; rho GTP-Binding Proteins; T-Lymphocytes | 2002 |
Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.
Topics: Alkyl and Aryl Transferases; Benzamides; Breast Neoplasms; Cell Cycle; Cell Division; Cyclin D1; Dimethylallyltranstransferase; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Farnesyltranstransferase; Gene Expression; Humans; Methionine; Proto-Oncogene Proteins c-myc; Receptors, Estrogen; Receptors, Progesterone; Response Elements; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
Topics: Alkyl and Aryl Transferases; Benzamides; Cell Division; Colonic Neoplasms; Enzyme Inhibitors; Humans; Methionine; Mevalonic Acid; Neoplasm Invasiveness; Pancreatic Neoplasms; Protein Prenylation; Signal Transduction; Tumor Cells, Cultured | 2003 |
Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.
Topics: Benzamides; Breast Neoplasms; Dimethylallyltranstransferase; Enzyme Inhibitors; Estrogen Receptor alpha; Estrogen Receptor beta; HeLa Cells; Humans; Immunohistochemistry; Luciferases; Methionine; Mutation; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; rhoC GTP-Binding Protein; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2005 |
Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; G1 Phase; Humans; Lactic Acid; Lovastatin; Methionine; Proteasome Endopeptidase Complex; Protein Prenylation; rap1 GTP-Binding Proteins; ras Proteins; Tumor Cells, Cultured; Up-Regulation | 2006 |
Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.
Topics: Alkyl and Aryl Transferases; Animals; Benzamides; Breast Neoplasms; Cattle; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Shape; Coculture Techniques; Collagen; Drug Combinations; Endothelial Cells; Farnesyltranstransferase; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Laminin; Methionine; Neoplasm Invasiveness; Protein Prenylation; Protein Processing, Post-Translational; Protein Transport; Proteoglycans; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein | 2006 |
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Topics: Acetylation; Alkyl and Aryl Transferases; Antineoplastic Agents; Benzamides; Enzyme Inhibitors; Farnesyltranstransferase; Histone Acetyltransferases; Histone Deacetylase 1; Histone Deacetylases; Histones; Humans; Methionine; Neoplasms; Promoter Regions, Genetic; Protein Processing, Post-Translational; Reverse Transcriptase Polymerase Chain Reaction; rhoB GTP-Binding Protein; RNA, Neoplasm; Tumor Cells, Cultured; Up-Regulation | 2007 |
Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Enzyme Inhibitors; Farnesyltranstransferase; Hodgkin Disease; Humans; K562 Cells; Methionine; Mice; Neoplasm Transplantation; Protein Prenylation; Protein Processing, Post-Translational; Simvastatin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2007 |
Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
Topics: Alkyl and Aryl Transferases; Benzamides; Farnesyltranstransferase; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Matrix Metalloproteinase 1; Methionine; Protein Prenylation; Rheumatic Diseases; Synovial Fluid | 2007 |
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.
Topics: Antineoplastic Agents; Benzamides; Cell Death; Cell Line, Tumor; Diphosphonates; Drug Screening Assays, Antitumor; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Imidazoles; Lovastatin; Male; Methionine; Mitochondria; Prostatic Neoplasms; Vorinostat; Zoledronic Acid | 2007 |
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Benzamides; Botulinum Toxins; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Lymphoma; Melanoma, Experimental; Membrane Proteins; Methionine; Mevalonic Acid; Mice; Pyrroles; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering | 2007 |
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing | 2008 |
Role for protein geranylgeranylation in adult T-cell leukemia cell survival.
Topics: Adult; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Nucleus; Cell Survival; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; I-kappa B Proteins; Leukemia-Lymphoma, Adult T-Cell; Methionine; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Polyisoprenyl Phosphates; Protein Prenylation; rab5 GTP-Binding Proteins; rac1 GTP-Binding Protein; Sesquiterpenes | 2009 |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin | 2009 |
Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells.
Topics: Animals; Benzamides; Cell Differentiation; Forkhead Transcription Factors; Gene Expression Regulation; Interleukin-17; Interleukin-6; Methionine; Mice; Mice, Inbred BALB C; Mice, Transgenic; Ovalbumin; Peptide Fragments; Prenylation; Receptors, Antigen, T-Cell, alpha-beta; Severe Combined Immunodeficiency; Simvastatin; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2009 |
Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Actins; Alkyl and Aryl Transferases; Benzamides; Diphosphonates; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Methionine; p21-Activated Kinases; Paxillin; Phosphorylation; Prostatic Neoplasms; Protein Prenylation; Pyridines; RNA Interference; Tumor Cells, Cultured | 2010 |
Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone.
Topics: Alkyl and Aryl Transferases; Apoptosis; Benzamides; Bone Density Conservation Agents; Bone Neoplasms; Caspases; Cell Division; Cell Survival; Diphosphonates; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression; Giant Cell Tumor of Bone; Humans; Methionine; Osteoprotegerin; Pamidronate; Prenylation; RANK Ligand; RNA, Messenger; S Phase; Tumor Cells, Cultured | 2011 |
Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors.
Topics: Alendronate; Alkyl and Aryl Transferases; Benzamides; Bone Density Conservation Agents; Cell Differentiation; Cell Nucleus; Enzyme Inhibitors; Farnesyltranstransferase; Humans; In Vitro Techniques; Male; Mesenchymal Stem Cells; Methionine; Osteoblasts; Osteogenesis; Protein Prenylation | 2011 |
Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines.
Topics: Alkyl and Aryl Transferases; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphoma, Large B-Cell, Diffuse; Methionine; Prednisone; Prenylation; Rituximab; Simvastatin; Vincristine | 2011 |
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts.
Topics: Animals; Apoptosis; Benzamides; Caspases; Cell Survival; Cells, Cultured; Cholesterol; Fibroblasts; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Methionine; Myofibroblasts; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Simvastatin | 2011 |
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.
Topics: Aging; Animals; Behavior, Animal; Benzamides; Cardiovascular Diseases; Drosophila melanogaster; Feeding Behavior; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longevity; Male; Methionine; Mice; Simvastatin; Ubiquinone | 2012 |
Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.
Topics: Animals; Benzamides; Blotting, Western; Cell Line; Cells, Cultured; Chlorocebus aethiops; COS Cells; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Methionine; Mice; Mitogen-Activated Protein Kinase 7; Muscle Fibers, Skeletal; Nitric Oxide Synthase Type III; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Thrombomodulin | 2015 |