methionine has been researched along with gamma-aminobutyric acid in 40 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (32.50) | 18.7374 |
1990's | 5 (12.50) | 18.2507 |
2000's | 10 (25.00) | 29.6817 |
2010's | 9 (22.50) | 24.3611 |
2020's | 3 (7.50) | 2.80 |
Authors | Studies |
---|---|
Daniels, VG; Murphy, S | 1 |
Cummins, CJ; Glover, RA; Sellinger, OZ | 1 |
Bradley, RJ; Linton, PH; Smythies, JR | 1 |
Dickerson, JW; Pao, SK | 1 |
Cuénod, M; Do, KQ; Gähwiler, BH; Jiang, ZP; Klancnik, JM | 1 |
Geddes, JW; Kurylo, E; Wood, JD | 1 |
Chalabian, ZhA | 1 |
Baldessarini, RJ; Yorke, C | 1 |
Borden, LA; Chan, CY; Czajkowski, CM; Farb, DH; Gibbs, TT; Schiller, GD | 1 |
Furukawa, T; Morishita, H; Ono, N; Tokunaga, T | 1 |
Künzle, H; Schnyder, H | 1 |
Kohl, RL; Perez-Polo, JR; Quay, WB | 1 |
Kanner, BI; Kleinberger-Doron, N | 1 |
Farkas, Z; Kása, P; Pákáski, M; Penke, B; Soós, K | 1 |
Burrell, LM; Casely, D; Farina, N; Johnston, CI; Risvanis, J; Woollard, D | 1 |
Amin, J | 1 |
Cahalan, MD; Chandy, KG; Fajloun, Z; Fathallah, M; Gargus, JJ; Regaya, I; Sabatier, JM; Shakkottai, VG; Tomita, H; Wulff, H | 1 |
Harrison, NL; Krasowski, MD; Lin, A; Nikolaeva, N; Nishikawa, K | 1 |
Gether, U; MacAulay, N; Meinild, AK; Zeuthen, T | 1 |
CHELDELIN, VH; CHRISTENSEN, BE; KING, TE; WANG, CH | 1 |
Costa, E; Grayson, DR; Guidotti, A | 1 |
Agis-Balboa, RC; Costa, E; Dong, E; Grayson, DR; Guidotti, A; Simonini, MV | 1 |
Hashimoto, T; Lewis, DA | 1 |
Strandskov, FB | 1 |
Chiara, DC; Cohen, JB; Husain, SS; Li, GD; Olsen, RW; Sawyer, GW | 1 |
Ikeda, T; Matsuki, N; Tamura, N; Yamada, MK | 1 |
Karasu, E; Sadan, G; Tasatargil, A | 1 |
Fisher, JL; Heidelberg, LS; Nimmich, ML | 1 |
Barnett, AS; Callicott, JH; Geramita, M; Kolachana, B; Marenco, S; Radulescu, E; Savostyanova, AA; Shen, J; Stern, A; Straub, RE; van der Veen, JW; Weinberger, DR; Zhang, F | 1 |
Harris, RA; Howard, RJ; Johnson, WD; Trudell, JR | 1 |
Bai, Y; Chang, F; Chen, F; Chen, L; Zhou, R | 1 |
Gopal, KV; Gross, GW; Moore, EJ; Wu, C | 1 |
Joseph, K; Moser, A; Prauss, K; Varatharajan, R | 1 |
Chang, J; Han, M; Kim, J | 1 |
Jiang, W; Lin, Q; Wang, L; Zhang, Y; Zhao, C | 1 |
Chandler, JD; Fernandes, J; Go, YM; Jones, DP; Liu, KH; Uppal, K | 1 |
Cui, D; Jiang, G; Kong, J; Niu, Y; Wang, G; Wang, W; Xu, M; Zhao, H; Zhao, Y | 1 |
Akolkar, B; Butterworth, MD; Fan, S; Fiehn, O; Hagopian, W; Krischer, JP; Lernmark, Å; Li, Q; Parikh, H; Rewers, M; She, JX; Toppari, J; Ziegler, AG | 1 |
Chen, YY; Chou, YH; Liu, MN; Yang, BH; Yang, KC | 1 |
Chen, L; Cui, L; Li, G; Liu, D; Qiu, J; Song, X; Sun, Y; Wang, C; Wang, J | 1 |
2 review(s) available for methionine and gamma-aminobutyric acid
Article | Year |
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Central and peripheral effects of sulfur amino acids: antagonism against central effect of angiotensin.
Topics: Amino Acids, Sulfur; Angiotensin II; Animals; Blood Pressure; Calcium; Cysteic Acid; Cysteine; Electric Stimulation; gamma-Aminobutyric Acid; Methionine; Muscle Contraction; Renin-Angiotensin System; Sympathetic Nervous System; Synaptic Transmission; Taurine | 1983 |
Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
Topics: Animals; Brain; Cell Adhesion Molecules, Neuronal; Epigenesis, Genetic; Extracellular Matrix Proteins; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Humans; Methionine; Models, Neurological; Nerve Tissue Proteins; Neurons; Reelin Protein; Schizophrenia; Serine Endopeptidases; Valproic Acid | 2003 |
38 other study(ies) available for methionine and gamma-aminobutyric acid
Article | Year |
---|---|
Postnatal amino acid uptake by the rat small intestine. Changes in membrane transport systems for amino acids associated with maturation of jejunal morphology.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Biological Transport, Active; gamma-Aminobutyric Acid; In Vitro Techniques; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Lysine; Methionine; Phenylalanine; Rats; Valine | 1979 |
Neuronal cues regulate uptake in cultured astrocytes.
Topics: Animals; Astrocytes; Brain; Bucladesine; Calcium; Cell Communication; Cells, Cultured; Deoxyglucose; gamma-Aminobutyric Acid; Methionine; Neurons; Norepinephrine; Ouabain; Potassium; Rats; Serotonin | 1979 |
Meeting report: Biochemical aspects of schizophrenia. Alabama, April 1975.
Topics: Acute Disease; Blood Platelets; Chronic Disease; Dopamine; Folic Acid; gamma-Aminobutyric Acid; Hallucinogens; Humans; Mesencephalon; Methionine; Monoamine Oxidase; Prolactin; Receptors, Dopamine; Schizophrenia; Serotonin; T-Lymphocytes | 1975 |
Effect of a low protein diet and isoenergetic amounts of a high protein diet in the weanling rat on the free amino acids of the brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Dietary Proteins; DNA; gamma-Aminobutyric Acid; Glycine; Histidine; Male; Methionine; Rats; Stimulation, Chemical | 1975 |
Release of endogenous amino acids, including homocysteic acid and cysteine sulphinic acid, from rat hippocampal slices evoked by electrical stimulation of Schaffer collateral-commissural fibres.
Topics: Amino Acids; Animals; Aspartic Acid; Cysteine; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Homocysteine; In Vitro Techniques; Kinetics; Male; Methionine; Nerve Fibers; Neurotransmitter Agents; Pyramidal Tracts; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Methionine-induced changes in glutamate, aspartate, glutamine, and gamma-aminobutyrate levels in brain tissue.
Topics: Animals; Aspartic Acid; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoniazid; Ketoglutaric Acids; Male; Methionine; Mice; Nerve Endings; Rats; Rats, Inbred Strains; Synaptosomes | 1985 |
[Change in the activity of a cell-free protein-synthesizing system with different functional states of the central nervous system].
Topics: Anesthesia; Animals; Brain; Cell-Free System; Chlorpromazine; gamma-Aminobutyric Acid; Hexobarbital; In Vitro Techniques; Methionine; Microsomes; Nerve Tissue Proteins; Pentylenetetrazole; Rabbits; Seizures; Semicarbazides; Sulfur Radioisotopes; Thiopental | 1972 |
Uptake and release of possible false transmitter amino acids by rat brain tissue.
Topics: Amino Acids; Aminolevulinic Acid; Animals; Aspartic Acid; Brain; Carbon Radioisotopes; Centrifugation, Density Gradient; Chromatography, Paper; Dinitrophenols; Electric Stimulation; Electrophoresis, Paper; gamma-Aminobutyric Acid; Glutamates; Glutamine; Glycine; Kinetics; Male; Methionine; Mitochondria; Ouabain; Potassium; Rats; Sodium; Subcellular Fractions; Sympatholytics; Synaptosomes; Temperature; Tritium | 1974 |
Modulation of neuronal function through benzodiazepine receptors: biochemical and electrophysiological studies of neurons in primary monolayer cell culture.
Topics: Animals; Benzodiazepines; Binding Sites; Cells, Cultured; Chick Embryo; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Methionine; Neurons; Receptors, Neurotransmitter; Synaptic Membranes | 1984 |
The isthmus-tegmentum complex in the turtle and rat: a comparative analysis of its interconnections with the optic tectum.
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Mesencephalon; Methionine; Rats; Species Specificity; Superior Colliculi; Tegmentum Mesencephali; Turtles | 1984 |
Elevation of gamma-aminobutyric acid in cultured rat C6 glioma cells following methionine supplementation.
Topics: Amino Acids; Animals; Cell Line; gamma-Aminobutyric Acid; Glioma; Glycine; Methionine; Rats; Serine | 1980 |
Identification of tryptophan residues critical for the function and targeting of the gamma-aminobutyric acid transporter (subtype A).
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Carrier Proteins; Cloning, Molecular; DNA Primers; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; HeLa Cells; Humans; Kinetics; Liposomes; Membrane Proteins; Membrane Transport Proteins; Methionine; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Organic Anion Transporters; Protein Structure, Secondary; Proteolipids; Recombinant Proteins; Tryptophan | 1994 |
Role of Leu(34)-Met(35) in neurotoxicity caused by human beta-amyloid (1-42) peptide in vitro.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Biomarkers; Cells, Cultured; gamma-Aminobutyric Acid; Humans; Leucine; Methionine; Nerve Tissue Proteins; Neurons; Neurotoxins; Peptide Fragments; Prosencephalon; Rats; Structure-Activity Relationship; Thiolester Hydrolases; Ubiquitin Thiolesterase | 1996 |
Inhibition of neutral endopeptidase, the degradative enzyme for natriuretic peptides, in rat kidney after oral SCH 42495.
Topics: Administration, Oral; Animals; Atrial Natriuretic Factor; Binding, Competitive; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Iodine Radioisotopes; Iodobenzenes; Kidney; Methionine; Neprilysin; Peptidyl-Dipeptidase A; Prodrugs; Rats; Rats, Sprague-Dawley; Renin; Time Factors | 1997 |
A single hydrophobic residue confers barbiturate sensitivity to gamma-aminobutyric acid type C receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Chloride Channels; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Membrane Proteins; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Pentobarbital; Receptors, GABA; Recombinant Proteins; Sequence Homology, Amino Acid; Thiopental; Tryptophan | 1999 |
Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.
Topics: Alanine; Amino Acid Sequence; Animals; Arginine; Cell Line; Cloning, Molecular; COS Cells; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Humans; Kinetics; Methionine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Neurotoxins; PC12 Cells; Peptides; Phenylalanine; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Binding; Rats; Scorpion Venoms; Sequence Homology, Amino Acid; Small-Conductance Calcium-Activated Potassium Channels; Threonine; Transfection; Valine | 2001 |
Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.
Topics: Amino Acid Sequence; Amino Acid Substitution; Anesthetics, General; Anesthetics, Intravenous; Animals; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Etomidate; gamma-Aminobutyric Acid; Humans; Methionine; Methohexital; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Propofol; Protein Structure, Tertiary; Rats; Receptors, GABA-A | 2001 |
Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.
Topics: Animals; Carrier Proteins; Electric Conductivity; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Hydrogen-Ion Concentration; Lithium; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Methionine; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transporters; Protein Conformation; Rats; Sodium; Structure-Activity Relationship; Threonine; Transfection; Tritium; Xenopus laevis | 2003 |
Methionine reversal of 2-chloro-4-aminobenzoic acid inhibition in Escherichia coli.
Topics: 4-Aminobenzoic Acid; Escherichia coli; gamma-Aminobutyric Acid; Methionine | 1951 |
Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Disease Models, Animal; DNA; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Extracellular Matrix Proteins; gamma-Aminobutyric Acid; Gene Expression; Globins; Glutamate Decarboxylase; Isoenzymes; Methionine; Methyl-CpG-Binding Protein 2; Mice; Models, Biological; Nerve Tissue Proteins; Promoter Regions, Genetic; Reelin Protein; Repressor Proteins; RNA, Messenger; Schizophrenia; Serine Endopeptidases | 2005 |
BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia.
Topics: Brain-Derived Neurotrophic Factor; Cohort Studies; Diazepam; Female; gamma-Aminobutyric Acid; Gene Expression; Gene Frequency; Genotype; Glutamate Decarboxylase; Humans; Isoenzymes; Male; Methionine; Polymorphism, Single Nucleotide; Prefrontal Cortex; Receptor, trkB; RNA, Messenger; Schizophrenia | 2006 |
Inhibition of Methionine Synthesis in Escherichia coli by 2-Chloro-4-Aminobenzoic Acid and Sulfanilamide.
Topics: Acids; Escherichia coli; gamma-Aminobutyric Acid; Methionine; Sulfanilamide; Sulfanilamides; Sulfonamides | 1947 |
Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.
Topics: Animals; Binding Sites; Blotting, Western; Brain; Cattle; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Etomidate; GABA Agonists; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Inhibitory Concentration 50; Methionine; Models, Molecular; Muscimol; Photoaffinity Labels; Radioligand Assay; Receptors, GABA; Sequence Analysis, Protein; Subcellular Fractions; Tritium | 2006 |
Conserved role of brain-derived neurotrophic factor in Val66Met: target-selective reinforcement of GABAergic synapses.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Embryo, Mammalian; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Methionine; Neurons; Polymorphism, Genetic; Probability; Rats; Rats, Wistar; Synapses; Transfection; Valine | 2006 |
Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Disease Models, Animal; Duodenum; Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Epinephrine; gamma-Aminobutyric Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sulfathiazoles | 2008 |
RNA editing of the GABA(A) receptor alpha3 subunit alters the functional properties of recombinant receptors.
Topics: Amino Acid Sequence; Cell Line, Transformed; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agents; gamma-Aminobutyric Acid; Humans; Isoleucine; Membrane Potentials; Methionine; Mutation; Patch-Clamp Techniques; Protein Structure, Tertiary; Receptors, GABA-A; Recombinant Proteins; RNA Editing; Time Factors; Transfection | 2009 |
Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT.
Topics: Adolescent; Adult; Age Factors; Catechol O-Methyltransferase; Female; gamma-Aminobutyric Acid; Genotype; Glutamate Decarboxylase; Gyrus Cinguli; Humans; Linkage Disequilibrium; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Protons; Statistics, Nonparametric; Valine; Young Adult | 2010 |
The TM2 6' position of GABA(A) receptors mediates alcohol inhibition.
Topics: Alcohols; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Cysteine; Cystine; DNA, Complementary; Drug Synergism; Electrophysiological Phenomena; Ethanol; Etomidate; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Methionine; Methyl Methanesulfonate; Molecular Dynamics Simulation; Oocytes; Patch-Clamp Techniques; Receptors, GABA-A; Tryptophan; Xenopus laevis | 2012 |
Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A.
Topics: Air Pollutants, Occupational; Amygdala; Animals; Anxiety; Benzhydryl Compounds; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Evoked Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; Glutamate Decarboxylase; In Vitro Techniques; Indolizines; Male; Methionine; Neural Inhibition; Neurons; Phenols; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2013 |
Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition.
Topics: Action Potentials; Animals; Bicuculline; Carnitine; Cell Count; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; GABA Antagonists; gamma-Aminobutyric Acid; Methionine; Mice; Mice, Inbred BALB C; Nerve Net; Neurons; Neuroprotective Agents | 2014 |
Transmitter self-regulation by extracellular glutamate in fresh human cortical slices.
Topics: Adult; Aged; Aspartic Acid; Cerebral Cortex; Chromatography, High Pressure Liquid; Extracellular Fluid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; In Vitro Techniques; Male; Methionine; Middle Aged; Neurons; Tetrodotoxin; Time Factors; Veratridine | 2014 |
Loss of divalent metal transporter 1 function promotes brain copper accumulation and increases impulsivity.
Topics: Adenosine Triphosphatases; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Cation Transport Proteins; Copper; Copper Transporter 1; Down-Regulation; Emotions; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; Impulsive Behavior; Iron; Male; Methionine; Mutation; Nonheme Iron Proteins; Rats; Rats, Inbred F344; Receptors, GABA-A | 2016 |
DNA methylation regulates gabrb2 mRNA expression: developmental variations and disruptions in l-methionine-induced zebrafish with schizophrenia-like symptoms.
Topics: Animals; Disease Models, Animal; DNA Methylation; gamma-Aminobutyric Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Methionine; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, GABA; RNA, Messenger; Schizophrenia; Zebrafish | 2016 |
Putrescine as indicator of manganese neurotoxicity: Dose-response study in human SH-SY5Y cells.
Topics: Adult; Aged; Biomarkers; Cell Line, Tumor; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Humans; Male; Manganese; Mass Spectrometry; Metabolomics; Methionine; Middle Aged; Nervous System; Neurotransmitter Agents; Polyamines; Putrescine; Succinates; Urea | 2018 |
Resistance against Ralstonia solanacearum in tomato depends on the methionine cycle and the γ-aminobutyric acid metabolic pathway.
Topics: Disease Resistance; gamma-Aminobutyric Acid; Gene Expression Profiling; Methionine; Plant Diseases; Proteome; Proteomics; Ralstonia solanacearum; Solanum lycopersicum; Transcriptome | 2019 |
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.
Topics: Alanine; Amino Acids, Branched-Chain; Autoantibodies; Child, Preschool; Dehydroascorbic Acid; Diabetes Mellitus, Type 1; Fatty Acids; Female; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamate Decarboxylase; Humans; Infant; Infant, Newborn; Insulin Antibodies; Longitudinal Studies; Male; Metabolome; Methionine; Phosphatidylethanolamines; Prodromal Symptoms; Proline; Risk; Triglycerides | 2020 |
Interactions between dopamine transporter and N-methyl-d-aspartate receptor-related amino acids on cognitive impairments in schizophrenia.
Topics: Amino Acids; Arginine; Aspartic Acid; Cognitive Dysfunction; Corpus Striatum; Cysteine; Dopamine; Dopamine Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamates; Humans; Methionine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tomography, Emission-Computed, Single-Photon; Tropanes | 2022 |
Application and prospect of quasi-targeted metabolomics in age-related hearing loss.
Topics: Acetylcholine; Amino Acids; Animals; Arginine; Chromatography, High Pressure Liquid; Coenzyme A; gamma-Aminobutyric Acid; Histamine; Methionine; Mice; Mice, Inbred C57BL; Piperidines; Presbycusis; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |