methionine has been researched along with fti 277 in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (15.65) | 18.2507 |
| 2000's | 65 (56.52) | 29.6817 |
| 2010's | 30 (26.09) | 24.3611 |
| 2020's | 2 (1.74) | 2.80 |
| Authors | Studies |
|---|---|
| Blaskovich, MA; Cox, AD; Der, CJ; Fossum, RD; Hamilton, AD; Lerner, EC; Qian, Y; Sebti, SM; Sun, J; Vogt, A | 1 |
| Bernhard, EJ; Cox, AD; Hamilton, AD; Kao, G; McKenna, WG; Muschel, RJ; Sebti, SM | 1 |
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 2 |
| Blaskovich, MA; Davies, P; Finder, JD; Hamilton, AD; Litz, JL; McGuire, TF; Qian, Y; Sebti, SM | 1 |
| Favre, G; Hamilton, AD; Miquel, K; Pradines, A; Qian, Y; Sebti, SM; Sun, J | 1 |
| Hamilton, AD; Knowles, DB; Lerner, EC; Qian, Y; Sebti, SM; Zhang, TT | 1 |
| Hamilton, AD; Qian, Y; Sebti, SM; Sun, J; Vogt, A | 1 |
| Hamilton, AD; Qian, Y; Sebti, SM; Sun, J | 1 |
| Bernhard, EJ; Hamilton, AD; McKenna, WG; Muschel, RJ; Qian, Y; Sebti, SM; Wu, JM | 1 |
| Coffey, RJ; Cox, AD; Der, CJ; Oldham, SM; Reynolds, ER; Sizemore, NS | 1 |
| Bredel, M; Freund, JM; Hamilton, AD; Pollack, IF; Sebti, SM | 1 |
| Blaskovich, MA; Davies, P; Hamilton, AD; Johnson, BA; Pitt, B; Qian, Y; Sebti, SM; Stark, WW; Vasudevan, A | 1 |
| Abrams, WR; Blaskovich, MA; Hamilton, AD; Kucich, U; Ohkanda, J; Rosenbloom, J; Rosenbloom, JC; Sebti, SM; Shen, G | 1 |
| Bifulco, M; Di Matola, T; Fenzi, G; Laezza, C; Rossi, G; Vitale, M | 1 |
| Mallon, RG; Paty, PB; Picon, A; Wojciechowicz, DC | 1 |
| Ader, I; Allal, C; Bonnet, J; Cohen-Jonathan, E; Daly-Schveitzer, N; Favre, G; Hamilton, AD; Monteil, S; Sebti, SM; Toulas, C | 1 |
| Bailey, R; Hamilton, AD; Harlan, JM; Kovach, NL; Liu, L; Moesner, P; Sebti, SM | 1 |
| Cheng, JQ; Coppola, D; Crespo, NC; Hamilton, AD; Jiang, K; Nicosia, SV; Sebti, SM | 1 |
| Blaskovich, MA; Boota, A; Davies, P; Hamilton, A; Johnson, B; Kagan, VE; Lee, KL; Liu, SX; Pitt, B; Sebti, SM | 1 |
| Hong, W; Horstmann, H; Pallen, CJ; Si, X; Xu, Y; Zeng, Q | 1 |
| Adjei, AA; Davis, JN; Erlichman, C; Kaufmann, SH; Svingen, PA | 1 |
| Coxon, FP; Hamilton, A; Helfrich, MH; Ralston, SH; Rogers, MJ; Sebti, S; Van't Hof, R | 1 |
| Andres, DA; Chan, TO; Cox, AD; Grana, TM; Reynolds, ER; Rusyn, EV; Shao, H | 1 |
| Corliss, BC; Djeu, JY; Gilvary, DL; Hamilton, AD; Leibson, PJ; Sebti, S; Straus, DB; Sun, J; Trapani, JA; Weber, MJ; Wei, S | 1 |
| Lee, J; Maity, A; O'Rourke, DM; Pore, N; Solomon, D | 1 |
| Adnane, J; Bizouarn, FA; Chen, Z; Hamilton, AD; Munoz-Antonia, T; Ohkanda, J; Sebti, SM | 1 |
| Brown, JM | 1 |
| Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z | 1 |
| Emala, CW; Hirshman, CA; Lee, HT; Lesh, RE; Panettieri, RA; Zhu, D | 1 |
| Chaqour, B; Macarak, E; Rosenbloom, J; Tamura, I | 1 |
| de Lamirande, E; Gagnon, C | 1 |
| Aletsee, C; Beros, A; Dazert, S; Mullen, L; Pak, K; Palacios, S; Ryan, AF | 1 |
| Bannerman, DD; Hamilton, AD; Harlan, JM; Li, X; Liu, L; Sebti, SM; Tupper, JC; Winn, RK | 1 |
| Avvedimento, EV; Bifulco, M; Candigliota, M; Cassano, S; Ceravolo, R; Cuda, G; Faniello, MC; Mele, E; Paternò, R; Perrotti, N; Perticone, F; Ruocco, A; Santillo, M; Schepis, F | 1 |
| Adamson, P; Baker, D; Greenwood, J; Hamilton, AD; Hankey, DJR; Pryce, G; Sebti, SM; Walters, CE | 1 |
| Aletsee, C; Brors, D; Dazert, S; Mullen, L; Pak, K; Palacios, S; Ryan, AF | 1 |
| Ader, I; Bonnet, J; Cohen-Jonathan, E; Dalenc, F; Delmas, C; Favre, G; Toulas, C | 1 |
| Bordier, BB; Casey, JL; Glenn, JS; Greenberg, HB; Kay, MA; Marion, PL; Ohashi, K | 1 |
| Hirohashi, S; Ino, Y; Nam, JS; Sakamoto, M | 1 |
| Barnett, JV; Gadbut, AP; Galper, JB; Li, G; Papageorge, AG; Tang, D; Ward, SM; Wu, L | 1 |
| Hohl, RJ; Holstein, SA; Wohlford-Lenane, CL | 1 |
| Aletsee, C; Kayali, AG; Melhus, A; Pak, K; Palacios, SD; Rivkin, AZ; Ryan, AF; Webster, NJ | 1 |
| Carloni, V; Giusti, S; Hamilton, AD; Mazzocca, A; Pantaleo, P; Sebti, SM | 1 |
| Balaguer, P; Carroll, JS; Cestac, P; Chouini, S; Doisneau-Sixou, SF; Favre, G; Faye, JC; Hamilton, AD; Poirot, M; Sebti, SM; Sutherland, RL | 1 |
| Bolick, SC; Boulware, D; Dalton, WS; Hamilton, AD; Landowski, TH; Ohkanda, J; Oshiro, MM; Sebti, SM | 1 |
| Clark, GJ; Ellis, CA; Riley, C; Telford, WG; Vallecorsa, T; Vos, MD; Wickline, M; Zujewskil, J | 1 |
| Girgert, R; Pfister, S; Schweizer, P; Wittrock, J | 1 |
| Kamiyama, M; Kondo, K; Kurata, H; Tajima, N; Taniguchi, K; Utsunomiya, K; Yokota, T | 1 |
| Comellas, A; Kamp, DW; Lecuona, E; Sznajder, JI; Upadhyay, D | 1 |
| Cestac, P; Doisneau-Sixou, SF; Favre, G; Faye, JC; Sutherland, RL | 1 |
| Bordier, BB; Casey, JL; Glenn, JS; Hamilton, AD; Kay, MA; Lee, SY; Liu, P; Marion, PL; Meuse, L; Ohashi, K; Ohkanda, J; Salazar, FH; Sebti, SM | 1 |
| Dryer, SE; Lhuillier, L | 1 |
| Inoue, M; Kusama, T; Matsumoto, Y; Mukai, M; Nakamura, H; Tatsuta, M | 1 |
| Barnard, J; Coffey, RJ; Du, J; Jiang, B | 1 |
| Nanda, A; Yamaguchi, M; Zhang, JH; Zhou, C | 1 |
| Bernhard, EJ; Cerniglia, GJ; Cohen-Jonathan, E; Koch, CJ; Mick, R; Rhim, JS; Shi, Y; Wu, J | 1 |
| Balaguer, P; Cestac, P; Doisneau-Sixou, S; Favre, G; Faye, JC; Médale-Giamarchi, C; Rochaix, P; Sarrabayrouse, G | 1 |
| Limnander, A; Niki, M; Oki, S; Pandolfi, PP; Rothman, PB; Yao, PM | 1 |
| Aoyama, N; Ikehara, N; Kasuga, M; Sakashita, M; Semba, S; Yokozaki, H | 1 |
| de las Heras, M; Fan, H; Fu, W; Maeda, N; Ortin, A | 1 |
| Boijoux, O; Boutonnet, C; Favre, G; Faye, JC; Giamarchi, C; Vagner, S | 1 |
| Chauvin, JP; Lecuit, T; Lemmers, C; Philippe, JM; Pilot, F | 1 |
| Efuet, ET; Keyomarsi, K | 1 |
| de Lamirande, E; Gagnon, C; O'Flaherty, C | 1 |
| Pooler, AM; Wurtman, RJ; Xi, SC | 1 |
| Inoue, M; Kusama, T; Mukai, M; Nakamura, H; Tatsuta, M | 1 |
| Broers, JL; Hennekam, RC; Kamps, M; Kuijpers, HJ; Marcelis, CL; Merckx, D; Ramaekers, FC; Smeets, HJ; Steijlen, PM; van den Wijngaard, A; van Steensel, MA; Verstraeten, VL; Zinn-Justin, S | 1 |
| Adnane, J; Bizouarn, F; Blaskovich, MA; Chellappan, S; Delarue, FL; Hamilton, AD; Hawker, J; Joshi, B; Ohkanda, J; Sebti, SM; Wang, DA; Zhu, K | 1 |
| Dibas, A; He, S; Prasanna, G; Yorio, T | 1 |
| Engert, A; Hansen, HP; Sasse, S; Tawadros, S; von Strandmann, EP; von Tresckow, B | 1 |
| Beck, JF; Bumbul, B; Sonnemann, J | 1 |
| Favre, G; Leveque, K; Sarrabayrouse, G; Synaeve, C; Tilkin-Mariamé, AF | 1 |
| Capanni, C; Columbaro, M; D'Apice, MR; Foisner, R; Lattanzi, G; Maraldi, NM; Mattioli, E; Novelli, G; Riccio, M; Santi, S; Squarzoni, S | 1 |
| Ichioka, F; Katoh, K; Kobayashi, R; Maki, M; Shibata, H | 1 |
| Hirashima, M; Katsuki, M; Kawasaki, K; Koide, H; Miyazawa, K; Miyazono, K; Morishita, Y; Sasaoka, T; Sase, H; Suda, T; Watabe, T; Yuki, K | 1 |
| Avnet, S; Baldini, N; Ghisu, S; Lattanzi, G; Maraldi, NM; Squarzoni, S; Zini, N | 1 |
| Albrecht, G; Gabriel, D; Heidinger, V; Hofmann, G; Ibig-Rehm, Y; Magnier, M; Simonen, M; Zimmermann, J | 1 |
| Sangle, GV; Shen, GX; Zhao, R | 1 |
| Amet, T; Arai, A; Miura, O; Nonaka, M; Saitoh, Y; Sugimoto, H; Takahashi, M; Uota, S; Yamamoto, N; Yamaoka, S | 1 |
| Horiuchi, N; Maeda, T | 1 |
| Cookson, MR; Fredenburg, RA; Grammatopoulos, TN; Lansbury, PT; Liu, Y; Liu, Z; Logan, T; Meray, RK | 1 |
| Hirose, K; Ikeda, K; Iwamoto, I; Kagami, S; Kanari, H; Nakajima, H; Owada, T; Saito, Y; Suto, A; Watanabe, N | 1 |
| Kang, KS; Kim, RJ; Kim, SR; Kohn, EA; Kong, G; Nam, JS; Park, JR; Park, SB; Roh, KJ; Tang, B; Wakefield, LM; Yang, YA | 1 |
| Carter, EA; Fischman, A; Fukaya, M; Inoue, Y; Kaneki, M; Ming-Yu, Y; Shinozaki, S; Tompkins, R; Yang, W; Yu, YM | 1 |
| Bridger, JM; Kill, IR; Mehta, IS | 1 |
| Härkönen, PL; Kalervo Väänänen, H; Sandholm, J; Virtanen, SS; Yegutkin, G | 1 |
| Di Giandomenico, D; Porcu, G; Ragnini-Wilson, A; Wilson, C | 1 |
| Huang, RQ; Shi, JX; Song, ZJ; Wu, Y; Yin, HX; Zhao, XD; Zhou, YT; Zhuang, Z | 1 |
| Cao, JY; Chen, SP; Fu, LW; Li, MZ; Liu, L; Liu, ZG; Mi, YJ; Qian, CN; Shao, JY; Xia, YF; Zeng, MS; Zhang, H; Zhang, X | 1 |
| Auclair, M; Bastard, JP; Boccara, F; Capeau, J; Caron-Debarle, M; Lefèvre, C; Vigouroux, C | 1 |
| Huang, L; Kumta, SM; Lau, CP; Leung, PY; Ng, PK; Tsui, SK | 1 |
| Choi, C; Kim, DM; Ryu, SW | 1 |
| Duque, G; Rivas, D; Vidal, C | 1 |
| Chung, KS; Han, G; Kim, BK; Kim, DM; Kim, HM; Lee, K; Oh, YK; Park, SK; Simon, JA; Song, A; Song, KB; Won, KJ; Won, M | 1 |
| Ageberg, M; Drott, K; Jerkeman, M; Lindén, O; Linderoth, J; Rydström, K | 1 |
| Chakir, J; Ghavami, S; Halayko, AJ; Jacques, E; Laviolette, M; McNeill, KD; Mutawe, MM; Schaafsma, D; Unruh, H | 1 |
| Chang, K; Chao, W; Feng, Y; Fischman, AJ; Ichinose, F; Kaneki, M; Kida, K; Mao, J; Scherrer-Crosbie, M; Tamura, Y; Tompkins, RG; Yamada, M; Yang, W; Yao, S; Yu, YM; Zou, L | 1 |
| Amann, G; Barr, FG; Clark, G; Houghton, P; Kenner, L; Kucia, M; Ratajczak, MZ; Schneider, G; Tarnowski, M | 1 |
| Herwald, H; Jeppsson, B; Rahman, M; Thorlacius, H; Zhang, S | 1 |
| Chetsawang, B; Govitrapong, P; Pirompul, N | 1 |
| Boone, C; Di Giandomenico, D; Lucisano, G; Mosca, MG; Parsons, AB; Porcu, G; Ragnini-Wilson, A | 1 |
| Acín-Perez, R; Andrés, V; Cabezas-Sánchez, P; Cámara, C; Enríquez, JA; Gonzalez-Gómez, C; López-Otín, C; Luque-García, JL; Megias, D; Osorio, FG; Rivera-Torres, J | 1 |
| Abdulla, A; Appelros, S; Awla, D; Hwaiz, R; Merza, M; Rahman, M; Regner, S; Thorlacius, H | 1 |
| Fischman, AJ; Kaneki, M; Kramer, J; Martyn, JA; Nakazawa, H; Tanaka, T; Tompkins, RG; Yamada, M; Yu, YM | 1 |
| Chu, UB; Duellman, T; Tao, Y; Weaver, SJ; Yang, J | 1 |
| Li, W; Liu, X; Tu, J; Yang, W | 1 |
| Kowluru, A; Syeda, KG | 1 |
| Channa, IS; Hashim, Z; Ilyas, A; Zarina, S | 1 |
| Ashton, N; Borland, SJ; Canfield, AE; Eyre, HJ; Gilmore, A; Hyde, GD; Inkson, CA; Kalra, PA; Pond, E; Ponnusamy, A; Sinha, S; Taylor, RF | 1 |
| Arif, M; Bratt, JM; Chang, KY; Filosto, S; Franzi, LM; Goldkorn, T; Kenyon, NJ; Last, JA; Ott, SP; Rabowsky, M; Zeki, AA | 1 |
| Azuma, Y; Futaki, S; Ise, S; Kawaguchi, Y; Kawano, K; Le, TK; Ohkanda, J; Takeuchi, T | 1 |
| Fujii, H; Kato, N; Le, TK; Li, M; Matsumi, C; Ohkanda, J; Parvatkar, P; Sun, J; Tsubamoto, M; Watanabe, T | 1 |
| Bian, F; Hou, Y; Jia, P; Liu, J; Shi, W; Song, J; Sun, S; Wu, H; Wu, Z; Zhang, Y | 1 |
| Kaneki, M; Nakazawa, H; Tsuji, D; Yorozu, T | 1 |
115 other study(ies) available for methionine and fti 277
| Article | Year |
|---|---|
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Transformation, Neoplastic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methionine; Molecular Sequence Data; Oligopeptides; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction; Transferases | 1995 |
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.
Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Embryo, Mammalian; Enzyme Inhibitors; Farnesyltranstransferase; Fibroblasts; Genes, myc; Genes, ras; Kinetics; Methionine; Radiation-Sensitizing Agents; Rats; Transfection; Transferases; Urinary Bladder Neoplasms | 1996 |
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyltranstransferase; Kinetics; Lovastatin; Methionine; Mice; Phosphorylation; Phosphotyrosine; Protein Prenylation; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Structure-Activity Relationship; Transfection; Transferases | 1996 |
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
Topics: Alkyl and Aryl Transferases; Animals; Benzamides; Enzyme Induction; Enzyme Inhibitors; Farnesyltranstransferase; GTP-Binding Proteins; Interleukin-1; Liver; Male; Methionine; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitrites; Protein Prenylation; Proto-Oncogene Proteins; rap GTP-Binding Proteins; ras Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factors; Transferases | 1997 |
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
Topics: Adenocarcinoma; Alkyl and Aryl Transferases; Apoptosis; Benzamides; Cell Division; Enzyme Inhibitors; G1 Phase; G2 Phase; Humans; Lung Neoplasms; Methionine; Mitosis; Resting Phase, Cell Cycle; Transferases; Tumor Cells, Cultured | 1997 |
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Topics: Alkyl and Aryl Transferases; Benzamides; Cell Division; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; GTP-Binding Proteins; Humans; Methionine; Peptides; Protein Prenylation; rap GTP-Binding Proteins; ras Proteins; Tumor Cells, Cultured | 1997 |
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
Topics: Alkyl and Aryl Transferases; Benzamides; Breast Neoplasms; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Female; Fibrosarcoma; G1 Phase; Head and Neck Neoplasms; Humans; Lovastatin; Methionine; Oligopeptides; Pancreatic Neoplasms; Protein Prenylation; Resting Phase, Cell Cycle; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 1997 |
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Division; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Lung Neoplasms; Methionine; Mice; Mice, Nude; Neoplasm Transplantation; Oncogene Protein p21(ras); Protein Prenylation; Signal Transduction | 1998 |
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
Topics: Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, ras; Humans; Methionine; Mutation; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Radiation Tolerance; Radiation-Sensitizing Agents; Time Factors; Tumor Cells, Cultured | 1998 |
Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade.
Topics: Alkyl and Aryl Transferases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Farnesyltranstransferase; Genes, ras; Genes, src; Methionine; Mutation; Proto-Oncogene Proteins c-raf; Rats; Up-Regulation | 1998 |
Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth.
Topics: Benzamides; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; GTP-Binding Proteins; Humans; Methionine; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Tumor Cells, Cultured; Tumor Stem Cell Assay | 1998 |
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Benzamides; Cell Division; Cells, Cultured; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; GTP-Binding Proteins; Kinetics; Lovastatin; Methionine; Microcirculation; Muscle, Smooth, Vascular; Protein Prenylation; Pulmonary Artery; rap GTP-Binding Proteins; ras Proteins; Rats; Transcription Factors | 1998 |
Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization.
Topics: Acyltransferases; Alkyl and Aryl Transferases; Benzamides; Cell Line; Cholera Toxin; Elastin; Enzyme Inhibitors; Fibroblasts; GTP Phosphohydrolases; Humans; Lung; Methionine; Protein Kinase C; Protein Prenylation; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta; Tropoelastin; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism.
Topics: Apoptosis; Benzamides; Caspases; Cell Division; Cell Line; Cysteine Proteinase Inhibitors; Dimethylallyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Methionine; Serpins; Thyroid Gland; Tumor Suppressor Protein p53; Viral Proteins | 1999 |
Characterization of lectin resistant cell populations derived from human colon carcinoma: correlation of K-Ras with beta1-6 branching of N-linked carbohydrate and CEA production.
Topics: Carcinoembryonic Antigen; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Lectins; Methionine; Phytohemagglutinins; Precipitin Tests; ras Proteins; Tumor Cells, Cultured | 1999 |
The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS.
Topics: Alkyl and Aryl Transferases; Cell Survival; Enzyme Inhibitors; Farnesyltranstransferase; Fibroblast Growth Factor 2; HeLa Cells; Humans; Methionine; Radiation Tolerance | 1999 |
Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s).
Topics: Benzamides; Cell Adhesion; Diterpenes; Fibronectins; Humans; Integrins; Jurkat Cells; Leukocytes; Lovastatin; Methionine; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; U937 Cells | 1999 |
The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis.
Topics: Alkyl and Aryl Transferases; Apoptosis; Cell Line; Enzyme Inhibitors; Farnesyltranstransferase; Female; Humans; Methionine; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2000 |
Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.
Topics: Animals; Benzamides; Cells, Cultured; Dimethylallyltranstransferase; Enzyme Inhibitors; Genes, ras; Interleukin-1; Male; Methionine; Muscle, Smooth, Vascular; Mutation; Platelet-Derived Growth Factor; Pulmonary Circulation; Rats; Superoxides; Transfection | 2000 |
Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome.
Topics: Alkyl and Aryl Transferases; Animals; Brefeldin A; Cell Membrane; CHO Cells; Cricetinae; Endosomes; Enzyme Inhibitors; Farnesyltranstransferase; Immediate-Early Proteins; Intestinal Mucosa; Methionine; Mice; Microvilli; Protein Prenylation; Protein Tyrosine Phosphatases; Recombinant Proteins; Transfection | 2000 |
Comparison of potential markers of farnesyltransferase inhibition.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Antineoplastic Agents; Biomarkers, Tumor; Carrier Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Farnesyltranstransferase; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; Humans; Immunoblotting; Immunohistochemistry; Inhibitory Concentration 50; Lamin Type A; Lamins; Methionine; Molecular Sequence Data; Nuclear Proteins; Peptides; Piperidines; Protein Precursors; Protein Prenylation; Pyridines; Signal Transduction; Transfection; Tumor Cells, Cultured | 2000 |
Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.
Topics: Animals; Apoptosis; Benzamides; Bone Resorption; Cell Differentiation; Cell Survival; Cells, Cultured; Chick Embryo; Cytoskeleton; Diphosphonates; Enzyme Inhibitors; Methionine; Mice; Osteoclasts; Protein Prenylation; Rabbits | 2000 |
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Contact Inhibition; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation; Genes, jun; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; NF-kappa B; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphatidylinositol 3-Kinases; Protein Prenylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor Protein-Tyrosine Kinases; Receptor, EphB4; Receptors, Eph Family; rhoA GTP-Binding Protein; Serum Response Factor; Signal Transduction; Tumor Stem Cell Assay | 2000 |
Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway.
Topics: Alkyl and Aryl Transferases; Cell Line; Cell Polarity; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Enzyme Activation; Enzyme Inhibitors; Granzymes; Humans; Interleukin-2; Killer Cells, Natural; Ligands; MAP Kinase Signaling System; Membrane Glycoproteins; Methionine; Mitogen-Activated Protein Kinases; Perforin; Pore Forming Cytotoxic Proteins; Protein Prenylation; ras Proteins; Serine Endopeptidases; Tumor Cells, Cultured | 2000 |
Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.
Topics: Cell Hypoxia; Down-Regulation; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lymphokines; Methionine; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; ras Proteins; Receptor, ErbB-2; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Cell Division; Cell Transformation, Neoplastic; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methionine; Mice; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Cells, Cultured | 2000 |
Therapeutic targets in radiotherapy.
Topics: Alkyl and Aryl Transferases; Antibodies, Monoclonal; Antineoplastic Agents; Cell Division; Cell Hypoxia; Dose Fractionation, Radiation; Enzyme Inhibitors; ErbB Receptors; Farnesyltranstransferase; Genes, ras; Head and Neck Neoplasms; Humans; Methionine; Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Tirapazamine; Triazines; Tumor Cells, Cultured | 2001 |
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
Topics: Acute Disease; Apoptosis; Benzamides; Deoxyuracil Nucleotides; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Tumor Cells, Cultured | 2001 |
Inhibition of geranylgeranylation blocks agonist-induced actin reorganization in human airway smooth muscle cells.
Topics: Actins; Alkyl and Aryl Transferases; Carbachol; Cells, Cultured; Endothelins; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Leucine; Lysophospholipids; Methionine; Microscopy, Fluorescence; Miotics; Muscle, Smooth; ras Proteins; rhoA GTP-Binding Protein; Stress Fibers; Trachea | 2001 |
Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.
Topics: Animals; Benzamides; Blotting, Northern; Cattle; Cells, Cultured; DNA Probes; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; In Situ Hybridization; Methionine; Muscle Spindles; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Physical Stimulation; Signal Transduction | 2001 |
The extracellular signal-regulated kinase (ERK) pathway is involved in human sperm function and modulated by the superoxide anion.
Topics: Acrosome Reaction; Amino Acid Motifs; Humans; In Vitro Techniques; Lysophosphatidylcholines; Male; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; ras Proteins; Sperm Capacitation; Spermatozoa; Substrate Specificity; Superoxides; Tyrosine | 2002 |
Ras/MEK but not p38 signaling mediates NT-3-induced neurite extension from spiral ganglion neurons.
Topics: Animals; Butadienes; Culture Techniques; Dimethyl Sulfoxide; Drug Synergism; Enzyme Inhibitors; Imidazoles; Methionine; Mitogen-Activated Protein Kinases; Neurites; Neurons; Neurotrophin 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; ras Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiral Ganglion | 2001 |
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
Topics: Apoptosis; Benzamides; Caspase 3; Caspases; Cell Death; Cells, Cultured; Diterpenes; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Lovastatin; Methionine; Polyisoprenyl Phosphates; Protein Prenylation; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Umbilical Veins | 2002 |
Protection of human endothelial cells from oxidative stress: role of Ras-ERK1/2 signaling.
Topics: Amino Acid Substitution; Apoptosis; Cells, Cultured; Cytoprotection; Endothelium, Vascular; Enzyme Inhibitors; Genes, Dominant; Genes, ras; Humans; Hydrogen Peroxide; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Oxidative Stress; Protein Isoforms; Protein Prenylation; Reactive Oxygen Species; Signal Transduction; Structure-Activity Relationship; Transfection | 2002 |
Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.
Topics: Acute Disease; Animals; Benzamides; Brain; Cell Line; Cell Membrane; Cell Movement; Dimethylallyltranstransferase; Disease Models, Animal; Drug Combinations; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Guinea Pigs; Leukocytes; Methionine; Mice; Mice, Inbred Strains; Multiple Sclerosis; Myelin Basic Protein; Protein Prenylation; Rats; Rats, Inbred Lew; rho GTP-Binding Proteins; T-Lymphocytes | 2002 |
The effects of laminin-1 on spiral ganglion neurons are dependent on the MEK/ERK signaling pathway and are partially independent of Ras.
Topics: Animals; Butadienes; Cells, Cultured; Imidazoles; Laminin; Methionine; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurites; Neurons; Nitriles; Pyridines; ras Proteins; Rats; Signal Transduction; Spiral Ganglion | 2002 |
RhoB controls the 24 kDa FGF-2-induced radioresistance in HeLa cells by preventing post-mitotic cell death.
Topics: Alkyl and Aryl Transferases; Cell Survival; Crotalid Venoms; DNA, Complementary; Enzyme Inhibitors; Farnesyltranstransferase; Fibroblast Growth Factor 2; Genes, Dominant; Glycoproteins; HeLa Cells; Humans; Methionine; Mitosis; Phospholipases A; Poly(ADP-ribose) Polymerases; Protein Isoforms; Radiation Tolerance; Radiation-Sensitizing Agents; ras Proteins; Reptilian Proteins; rhoB GTP-Binding Protein | 2002 |
A prenylation inhibitor prevents production of infectious hepatitis delta virus particles.
Topics: Alkyl and Aryl Transferases; Cells, Cultured; Enzyme Inhibitors; Farnesyltranstransferase; Hepatitis Delta Virus; Hepatocytes; Humans; Methionine; Protein Prenylation; Tumor Cells, Cultured; Virion; Virus Assembly; Virus Replication | 2002 |
Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.
Topics: alpha Catenin; beta Catenin; Cadherins; Cell Aggregation; Cell Division; Cytoskeletal Proteins; Desmoplakins; Enzyme Inhibitors; Genes, ras; Humans; Methionine; Neoplasm Metastasis; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured | 2002 |
TGFbeta regulates the expression of G alpha(i2) via an effect on the localization of ras.
Topics: Animals; Carbachol; Cardiotonic Agents; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Farnesol; Gene Expression Regulation, Developmental; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Atria; Heart Rate; Methionine; Myocytes, Cardiac; Parasympathetic Nervous System; Promoter Regions, Genetic; Proto-Oncogene Proteins; ras Proteins; Transforming Growth Factor beta | 2002 |
Isoprenoids influence expression of Ras and Ras-related proteins.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cycloheximide; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; K562 Cells; Leucine; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; rap1 GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Time Factors; Transcription, Genetic; Up-Regulation | 2002 |
Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media.
Topics: Animals; Butadienes; Disease Models, Animal; Ear, Middle; Enzyme Inhibitors; Haemophilus Infections; Haemophilus influenzae; Hyperplasia; In Vitro Techniques; Male; Methionine; Mitogen-Activated Protein Kinases; Mucous Membrane; Nitriles; Otitis Media; ras Proteins; Rats; Signal Transduction; Time Factors | 2002 |
Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.
Topics: Alkyl and Aryl Transferases; CDC2-CDC28 Kinases; CDC28 Protein Kinase, S cerevisiae; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Farnesyltranstransferase; G2 Phase; Gene Expression; Humans; Methionine; Mitosis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-raf; rap1 GTP-Binding Proteins; ras Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2003 |
Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.
Topics: Alkyl and Aryl Transferases; Benzamides; Breast Neoplasms; Cell Cycle; Cell Division; Cyclin D1; Dimethylallyltranstransferase; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Farnesyltranstransferase; Gene Expression; Humans; Methionine; Proto-Oncogene Proteins c-myc; Receptors, Estrogen; Receptors, Progesterone; Response Elements; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.
Topics: Alkyl and Aryl Transferases; Apoptosis; Cell Division; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Methionine; Multiple Myeloma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2003 |
Tamoxifen and the farnesyl transferase inhibitor FTI-277 synergize to inhibit growth in estrogen receptor-positive breast tumor cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Drug Synergism; Enzyme Inhibitors; Female; Humans; Methionine; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured | 2003 |
Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF.
Topics: Alkyl and Aryl Transferases; Brain-Derived Neurotrophic Factor; Cell Division; Enzyme Inhibitors; Farnesyltranstransferase; Genes, myc; Humans; Methionine; Neuroblastoma; ras Proteins; Receptor, trkB; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured | 2003 |
Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells.
Topics: Amides; Animals; Arteriosclerosis; Cell Division; Cells, Cultured; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Leucine; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein | 2003 |
Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway.
Topics: Butadienes; Cell Membrane; Enzyme Inhibitors; Epithelial Cells; Fibroblast Growth Factor 10; Fibroblast Growth Factors; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Methionine; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; ras Proteins; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured | 2003 |
Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI-277 on inhibition of MCF-7 breast cancer cell-cycle progression.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Farnesyltranstransferase; Genes, myc; Humans; Methionine; Neoplasms, Hormone-Dependent; Tamoxifen; Tumor Cells, Cultured | 2003 |
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
Topics: Alkyl and Aryl Transferases; Animals; Antiviral Agents; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis D; Hepatitis Delta Virus; Humans; Methionine; Mice; Mice, Transgenic; Oligopeptides; Protein Prenylation; RNA Editing; Viremia; Virus Replication | 2003 |
Ras is a mediator of TGFbeta1 signaling in developing chick ciliary ganglion neurons.
Topics: Alkyl and Aryl Transferases; Animals; Cells, Cultured; Chick Embryo; DNA-Binding Proteins; Enzyme Inhibitors; Farnesyltranstransferase; Ganglia, Parasympathetic; Methionine; Neurons; Phosphorylation; Polyenes; Polyunsaturated Alkamides; Potassium Channels, Calcium-Activated; ras Proteins; Signal Transduction; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
Topics: Alkyl and Aryl Transferases; Benzamides; Cell Division; Colonic Neoplasms; Enzyme Inhibitors; Humans; Methionine; Mevalonic Acid; Neoplasm Invasiveness; Pancreatic Neoplasms; Protein Prenylation; Signal Transduction; Tumor Cells, Cultured | 2003 |
Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta.
Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, Dominant; Intestinal Mucosa; Methionine; Mice; Mutation; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; rhoA GTP-Binding Protein; Transfection; Transforming Growth Factor beta; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2004 |
Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model.
Topics: Alkyl and Aryl Transferases; Animals; Dimethyl Sulfoxide; Dogs; Enzyme Inhibitors; Farnesyltranstransferase; Female; Free Radical Scavengers; Male; Methionine; Mitogen-Activated Protein Kinase Kinases; Models, Animal; Phosphorylation; ras Proteins; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2004 |
Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival.
Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Radiation-Sensitizing Agents; Signal Transduction; Xenograft Model Antitumor Assays | 2005 |
Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.
Topics: Benzamides; Breast Neoplasms; Dimethylallyltranstransferase; Enzyme Inhibitors; Estrogen Receptor alpha; Estrogen Receptor beta; HeLa Cells; Humans; Immunohistochemistry; Luciferases; Methionine; Mutation; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; rhoC GTP-Binding Protein; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2005 |
Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation.
Topics: Animals; Apoptosis; Benzamides; Bone Marrow Cells; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; Gene Expression Regulation, Leukemic; Imatinib Mesylate; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Methionine; Mice; Oncogene Proteins v-abl; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoproteins; Phosphoric Monoester Hydrolases; Piperazines; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; ras Proteins; RNA-Binding Proteins; Signal Transduction | 2005 |
BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms.
Topics: Adenocarcinoma; Adenoma; Apoptosis; Base Sequence; Cell Proliferation; Colorectal Neoplasms; DNA Fragmentation; Enzyme Inhibitors; Female; Genes, ras; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Methionine; Middle Aged; Mutation; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins B-raf; Tumor Cells, Cultured | 2005 |
Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines.
Topics: Animals; Butadienes; Cell Transformation, Viral; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Flavonoids; Jaagsiekte sheep retrovirus; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Methionine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; ras Proteins; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2005 |
Chemical-based translational induction of luciferase expression: an efficient tool for in vivo screening of protein farnesylation inhibitors.
Topics: Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Luciferases; Methionine; Protein Biosynthesis; Protein Prenylation | 2005 |
Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation.
Topics: Alkyl and Aryl Transferases; Animals; Cell Nucleus; Cells, Cultured; Centrosome; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Epithelial Cells; Gene Expression Regulation, Developmental; Intercellular Junctions; Lamins; Methionine; Microtubules; Morphogenesis; Nuclear Envelope; Oligonucleotide Array Sequence Analysis | 2006 |
Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; G1 Phase; Humans; Lactic Acid; Lovastatin; Methionine; Proteasome Endopeptidase Complex; Protein Prenylation; rap1 GTP-Binding Proteins; ras Proteins; Tumor Cells, Cultured; Up-Regulation | 2006 |
Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation.
Topics: Androstadienes; Benzamides; Butadienes; Extracellular Signal-Regulated MAP Kinases; Fetal Blood; Humans; Hydrogen Peroxide; Male; MAP Kinase Kinase 1; Methionine; Nitric Oxide; Nitriles; Okadaic Acid; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Recombinant Proteins; Serum Albumin, Bovine; Sperm Capacitation; Tyrosine; Wortmannin | 2006 |
The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons.
Topics: Animals; Animals, Newborn; beta-Cyclodextrins; Blotting, Western; Cell Fractionation; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Methionine; Neurites; Neurons; Phospholipids; Pravastatin; Rats; rhoA GTP-Binding Protein; Time Factors | 2006 |
Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.
Topics: Alkyl and Aryl Transferases; Animals; Benzamides; Breast Neoplasms; Cattle; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Shape; Coculture Techniques; Collagen; Drug Combinations; Endothelial Cells; Farnesyltranstransferase; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Laminin; Methionine; Neoplasm Invasiveness; Protein Prenylation; Protein Processing, Post-Translational; Protein Transport; Proteoglycans; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; rhoC GTP-Binding Protein | 2006 |
Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation.
Topics: Adult; Bone and Bones; Cell Survival; Cells, Cultured; Child, Preschool; Female; Fibroblasts; Heterozygote; Humans; Imaging, Three-Dimensional; Immunohistochemistry; Lamin Type A; Lovastatin; Male; Methionine; Models, Molecular; Mutation; Nuclear Proteins; Progeria; Protein Precursors; Protein Prenylation; Radiography | 2006 |
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.
Topics: Acetylation; Alkyl and Aryl Transferases; Antineoplastic Agents; Benzamides; Enzyme Inhibitors; Farnesyltranstransferase; Histone Acetyltransferases; Histone Deacetylase 1; Histone Deacetylases; Histones; Humans; Methionine; Neoplasms; Promoter Regions, Genetic; Protein Processing, Post-Translational; Reverse Transcriptase Polymerase Chain Reaction; rhoB GTP-Binding Protein; RNA, Neoplasm; Tumor Cells, Cultured; Up-Regulation | 2007 |
Parallel signaling pathways in endothelin-1-induced proliferation of U373MG astrocytoma cells.
Topics: Astrocytoma; Calcium Signaling; Cell Line, Tumor; Cell Proliferation; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Estrenes; Extracellular Signal-Regulated MAP Kinases; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Methionine; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyrrolidinones; Receptor Protein-Tyrosine Kinases; Receptor, Endothelin B; Signal Transduction | 2007 |
Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Enzyme Inhibitors; Farnesyltranstransferase; Hodgkin Disease; Humans; K562 Cells; Methionine; Mice; Neoplasm Transplantation; Protein Prenylation; Protein Processing, Post-Translational; Simvastatin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2007 |
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.
Topics: Antineoplastic Agents; Benzamides; Cell Death; Cell Line, Tumor; Diphosphonates; Drug Screening Assays, Antitumor; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Imidazoles; Lovastatin; Male; Methionine; Mitochondria; Prostatic Neoplasms; Vorinostat; Zoledronic Acid | 2007 |
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Atorvastatin; Benzamides; Botulinum Toxins; Cell Line, Tumor; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Lymphoma; Melanoma, Experimental; Membrane Proteins; Methionine; Mevalonic Acid; Mice; Pyrroles; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering | 2007 |
Drugs affecting prelamin A processing: effects on heterochromatin organization.
Topics: Acetylcysteine; Adult; Antimetabolites, Antineoplastic; Azacitidine; Cell Nucleus; Cells, Cultured; Chromatin Assembly and Disassembly; Decitabine; DNA-Binding Proteins; Enzyme Inhibitors; Farnesyltranstransferase; Fibroblasts; Heterochromatin; Humans; Lamin Type A; Membrane Proteins; Methionine; Nuclear Lamina; Nuclear Proteins; Protein Precursors; Protein Prenylation | 2008 |
Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4).
Topics: Blotting, Western; Carrier Proteins; Cell Line; Electrophoretic Mobility Shift Assay; Endosomal Sorting Complexes Required for Transport; Humans; Methionine; Microscopy, Fluorescence; Molecular Sequence Data; Protein Binding; Protein Prenylation; Protein Structure, Tertiary; Recombinant Proteins; Vesicular Transport Proteins | 2008 |
Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells.
Topics: Animals; Cell Differentiation; Embryo, Mammalian; Embryonic Stem Cells; Endothelial Cells; Enzyme Inhibitors; Methionine; Mice; Mice, Inbred C57BL; Platelet Endothelial Cell Adhesion Molecule-1; Proto-Oncogene Proteins p21(ras); Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
Effects of prelamin A processing inhibitors on the differentiation and activity of human osteoclasts.
Topics: Acetylcysteine; Biomarkers; Cell Differentiation; Cells, Cultured; Humans; Lamin Type A; Methionine; Nuclear Proteins; Osteoclasts; Protein Precursors | 2008 |
High-content assay to study protein prenylation.
Topics: Cell Line, Tumor; Cell Membrane; Dimethylallyltranstransferase; Diphosphonates; Enzyme Inhibitors; Genes, Reporter; Geranyltranstransferase; Green Fluorescent Proteins; Humans; Image Processing, Computer-Assisted; Imidazoles; Luciferases; Methionine; Mevalonic Acid; Protein Prenylation; ras Proteins; Reproducibility of Results; RNA, Small Interfering; Transfection; Zoledronic Acid | 2008 |
Transmembrane signaling pathway mediates oxidized low-density lipoprotein-induced expression of plasminogen activator inhibitor-1 in vascular endothelial cells.
Topics: Antibodies; Blotting, Western; Butylated Hydroxytoluene; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Hydrogen Peroxide; Lipoproteins, LDL; Methionine; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, LDL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Scavenger Receptors, Class E; Signal Transduction | 2008 |
Role for protein geranylgeranylation in adult T-cell leukemia cell survival.
Topics: Adult; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Nucleus; Cell Survival; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; I-kappa B Proteins; Leukemia-Lymphoma, Adult T-Cell; Methionine; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Polyisoprenyl Phosphates; Protein Prenylation; rab5 GTP-Binding Proteins; rac1 GTP-Binding Protein; Sesquiterpenes | 2009 |
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Benzamides; Cell Differentiation; Chromones; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoquinolines; Leptin; Methionine; Mevalonic Acid; Mice; Morpholines; Polyisoprenyl Phosphates; Protein Prenylation; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Simvastatin; Sulfonamides; Wortmannin | 2009 |
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Topics: alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Cell Membrane; Chlorocebus aethiops; COS Cells; Cysteine; Endoplasmic Reticulum; Humans; Intracellular Membranes; Methionine; Mice; Neurons; Parkinson Disease; Prenylation; Proteasome Endopeptidase Complex; Protein Binding; Ubiquitin Thiolesterase | 2009 |
Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells.
Topics: Animals; Benzamides; Cell Differentiation; Forkhead Transcription Factors; Gene Expression Regulation; Interleukin-17; Interleukin-6; Methionine; Mice; Mice, Inbred BALB C; Mice, Transgenic; Ovalbumin; Peptide Fragments; Prenylation; Receptors, Antigen, T-Cell, alpha-beta; Severe Combined Immunodeficiency; Simvastatin; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2009 |
Ras activation contributes to the maintenance and expansion of Sca-1pos cells in a mouse model of breast cancer.
Topics: Aldehyde Dehydrogenase; Animals; Antigens, Ly; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinases; Membrane Proteins; Methionine; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplastic Stem Cells; Phosphorylation; Protein Prenylation; ras Proteins; Signal Transduction; Spheroids, Cellular | 2010 |
Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Male; MAP Kinase Kinase 4; Methionine; Mice; Mice, Inbred C57BL; Simvastatin; Spleen | 2010 |
Progeria, the nucleolus and farnesyltransferase inhibitors.
Topics: Cell Nucleolus; Child; Chromosomal Proteins, Non-Histone; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Lamin Type A; Methionine; Progeria | 2010 |
Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Actins; Alkyl and Aryl Transferases; Benzamides; Diphosphonates; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Methionine; p21-Activated Kinases; Paxillin; Phosphorylation; Prostatic Neoplasms; Protein Prenylation; Pyridines; RNA Interference; Tumor Cells, Cultured | 2010 |
A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics.
Topics: Aurora Kinases; Chromosomes, Fungal; Down-Regulation; Enzyme Inhibitors; Farnesyltranstransferase; Genome, Fungal; HeLa Cells; Humans; MAP Kinase Signaling System; Methionine; Molecular Mimicry; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription, Genetic | 2010 |
Potential role of Ras in cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; MAP Kinase Signaling System; Methionine; Rabbits; Random Allocation; ras Proteins; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2010 |
Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Blotting, Western; Bone Density Conservation Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Chromosomal Proteins, Non-Histone; Cisplatin; Diphosphonates; Drug Synergism; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunohistochemistry; Kaplan-Meier Estimate; Male; Methionine; Microfilament Proteins; Middle Aged; Multivariate Analysis; Nasopharyngeal Neoplasms; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Young Adult; Zoledronic Acid | 2010 |
Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin.
Topics: Acetylcysteine; Adult; Antioxidants; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cellular Senescence; Coronary Vessels; Cyclin-Dependent Kinase Inhibitor p21; Drug Therapy, Combination; Endothelial Cells; Farnesyltranstransferase; HIV Infections; HIV Protease Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lamin Type A; Lopinavir; Metalloporphyrins; Methionine; Middle Aged; Nuclear Proteins; Oxidative Stress; Paris; Pravastatin; Protein Precursors; Pyrimidinones; Ritonavir; Time Factors; Tumor Suppressor Protein p53 | 2010 |
Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone.
Topics: Alkyl and Aryl Transferases; Apoptosis; Benzamides; Bone Density Conservation Agents; Bone Neoplasms; Caspases; Cell Division; Cell Survival; Diphosphonates; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression; Giant Cell Tumor of Bone; Humans; Methionine; Osteoprotegerin; Pamidronate; Prenylation; RANK Ligand; RNA, Messenger; S Phase; Tumor Cells, Cultured | 2011 |
Long-term treatment of farnesyltransferase inhibitor FTI-277 induces neurotoxicity of hippocampal neurons from rat embryo in a ROS-dependent manner.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Farnesyltranstransferase; Hippocampus; Methionine; Neurons; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2010 |
Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors.
Topics: Alendronate; Alkyl and Aryl Transferases; Benzamides; Bone Density Conservation Agents; Cell Differentiation; Cell Nucleus; Enzyme Inhibitors; Farnesyltranstransferase; Humans; In Vitro Techniques; Male; Mesenchymal Stem Cells; Methionine; Osteoblasts; Osteogenesis; Protein Prenylation | 2011 |
Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.
Topics: Anthracenes; Apoptosis; Blotting, Western; Cell Proliferation; E1A-Associated p300 Protein; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Luciferases; MAP Kinase Signaling System; Methionine; Piperazines; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; rhoB GTP-Binding Protein; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2011 |
Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines.
Topics: Alkyl and Aryl Transferases; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphoma, Large B-Cell, Diffuse; Methionine; Prednisone; Prenylation; Rituximab; Simvastatin; Vincristine | 2011 |
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts.
Topics: Adult; Airway Remodeling; Alkyl and Aryl Transferases; Asthma; Bronchi; Case-Control Studies; Cells, Cultured; Dose-Response Relationship, Drug; Farnesyltranstransferase; Fibroblasts; Fibronectins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leucine; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin; Time Factors; Transforming Growth Factor beta1; Young Adult | 2011 |
Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
Topics: Animals; Bacterial Load; Cecum; Cytokines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Farnesyltranstransferase; Heart Function Tests; Hemodynamics; HMGB1 Protein; Lung; Male; Methionine; Mice; Mice, Inbred C57BL; Protein Prenylation; Sepsis; Spleen; T-Lymphocytes | 2011 |
RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL12; Enzyme Inhibitors; Hepatocyte Growth Factor; Humans; Insulin; Insulin-Like Growth Factor II; Methionine; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Metastasis; Phosphorylation; Proto-Oncogene Proteins c-akt; Pseudopodia; ras-GRF1; Rhabdomyosarcoma, Alveolar; RNA Interference; RNA, Messenger; RNA, Small Interfering; Up-Regulation | 2012 |
Streptococcal m1 protein triggers farnesyltransferase-dependent formation of CXC chemokines in alveolar macrophages and neutrophil infiltration of the lungs.
Topics: Acute Lung Injury; Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Carrier Proteins; Chemokines, CXC; Enzyme-Linked Immunosorbent Assay; Farnesyltranstransferase; Flow Cytometry; Lung; Macrophages, Alveolar; Male; Methionine; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Pulmonary Edema; Real-Time Polymerase Chain Reaction; Streptococcus pyogenes | 2012 |
Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Cell Line; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Methamphetamine; Methionine; Neurons; ras Proteins | 2013 |
Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Farnesyltranstransferase; Female; Humans; Lung Neoplasms; Melanoma; Methionine; p21-Activated Kinases | 2013 |
Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.
Topics: Adenosine Triphosphate; Adolescent; Amino Acids; Animals; Child; Diphosphonates; Female; Fibroblasts; Galactose; Gene Expression Regulation; Glucose; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Lamin Type A; Male; Methionine; Mice; Mitochondria; Mutation; Nuclear Proteins; Oxygen Consumption; Pravastatin; Progeria; Protein Precursors; Proteomics; Skin; Zoledronic Acid | 2013 |
Farnesyltransferase regulates neutrophil recruitment and tissue damage in acute pancreatitis.
Topics: Acinar Cells; Acute Disease; Amylases; Animals; Arginine; Cells, Cultured; Chemokine CXCL2; Enzyme Inhibitors; Farnesyltranstransferase; Lung; Macrophage-1 Antigen; Male; Methionine; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Pancreas; Pancreatitis; Peroxidase; Signal Transduction; Taurocholic Acid; Trypsin; Trypsinogen | 2014 |
Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle.
Topics: Animals; Burns; Farnesyltranstransferase; Insulin Resistance; Male; Methionine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Protein Prenylation | 2015 |
Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.
Topics: Animals; Benzamides; Blotting, Western; Cell Line; Cells, Cultured; Chlorocebus aethiops; COS Cells; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kruppel-Like Transcription Factors; Methionine; Mice; Mitogen-Activated Protein Kinase 7; Muscle Fibers, Skeletal; Nitric Oxide Synthase Type III; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Thrombomodulin | 2015 |
Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation.
Topics: Animals; B7-H1 Antigen; Cecum; Cells, Cultured; Disease Models, Animal; Farnesyltranstransferase; Humans; Lymphocyte Activation; Lymphocytes; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Programmed Cell Death 1 Receptor; Sepsis; Signal Transduction; Spleen | 2017 |
Inhibition of Prenylation Promotes Caspase 3 Activation, Lamin B Degradation and Loss in Metabolic Cell Viability in Pancreatic β-Cells.
Topics: Animals; Caspase 3; Cell Survival; Cells, Cultured; Farnesyltranstransferase; Glucose; Humans; Insulin-Secreting Cells; Lamin Type B; Male; Methionine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Octoxynol; p38 Mitogen-Activated Protein Kinases; Polyethylene Glycols; Protein Prenylation; Proteolysis; Rats; Rats, Sprague-Dawley; Simvastatin | 2017 |
Alendronate and FTI-277 combination as a possible therapeutic approach for hepatocellular carcinoma: An in vitro study.
Topics: Alendronate; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Liver Neoplasms; Methionine; Proteomics; Signal Transduction; Tandem Mass Spectrometry; Time Factors | 2018 |
FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.
Topics: alpha-Galactosidase; Animals; Apoptosis; Cattle; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Humans; Male; Methionine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteogenesis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Renal Insufficiency, Chronic; Signal Transduction; Vascular Calcification | 2018 |
Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Enzyme Inhibitors; Eosinophils; Epithelial Cells; Farnesyltranstransferase; Humans; Inflammation; Lung; Male; Methionine; Mice; Mice, Inbred BALB C; Ovalbumin; Polyisoprenyl Phosphates; ras Proteins; Sesquiterpenes; Signal Transduction | 2018 |
Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine.
Topics: Amines; Cell Membrane; Cell Membrane Permeability; Cell-Penetrating Peptides; Coordination Complexes; Drug Carriers; Endocytosis; HeLa Cells; Humans; Methionine; Oligopeptides; Picolinic Acids; Zinc | 2019 |
A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf.
Topics: Enzyme Inhibitors; Methionine; Peptidomimetics; Prenylation; Protein Serine-Threonine Kinases; ras Proteins | 2019 |
Progesterone attenuates Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cerebral Cortex; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Gene Knockout Techniques; Gene Silencing; GRB2 Adaptor Protein; Humans; Membrane Proteins; Methionine; Neurons; Neuroprotection; Progesterone; Proteomics; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Signal Transduction; Tandem Mass Spectrometry | 2020 |
Protective effects of farnesyltransferase inhibitor on sepsis-induced morphological aberrations of mitochondria in muscle and increased circulating mitochondrial DNA levels in mice.
Topics: Animals; DNA, Mitochondrial; Farnesyltranstransferase; Male; Methionine; Mice; Mitochondria; Muscle, Skeletal; Protective Agents; Sepsis; Time Factors | 2021 |