methionine has been researched along with fluorouracil in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (43.48) | 18.7374 |
| 1990's | 8 (17.39) | 18.2507 |
| 2000's | 9 (19.57) | 29.6817 |
| 2010's | 6 (13.04) | 24.3611 |
| 2020's | 3 (6.52) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Freshney, RI; Morgan, D | 1 |
| Kaibara, N; Maeta, M; Sugihara, K | 1 |
| Endo, M; Goseki, N; Kosaki, G; Onodera, T | 1 |
| Auther, C; Ishikawa, M; Kawachi, S; Kosaki, G; Matsumoto, T; Mori, S; Nakajima, T; Nishihira, T; Sugihara, K; Takahashi, M | 1 |
| Eickbohm, JE; Ewers, R; Görögh, T; Holdener, EE; Lippert, B | 1 |
| Bertino, JR; Coronnello, M; Criscuoli, L; Gualtieri, M; Mazzei, T; Mini, E; Periti, P | 1 |
| Flanigen-Roat, DT; Ip, MM; Milholland, RJ | 1 |
| Singhal, RL; Valadares, JR | 1 |
| Pitot, HC; Wilkinson, DS | 1 |
| de Robichon-Szulmajster, H; Masselot, M | 1 |
| Ofengand, J | 1 |
| De Kloet, SR; Mayo, VS | 1 |
| Gray, PN; Rachmeller, M | 1 |
| Baliga, BS; Hendler, S; Srinivasan, PR | 1 |
| Cramer, F; Gauss, DH; Maelicke, A; von der Haar, F | 1 |
| Koenig, H | 1 |
| Acs, G; Tavitian, A; Uretsky, SC | 1 |
| Andrean, BA; De Kloet, SR; Mayo, VS | 1 |
| Andrean, BA; De Kloet, SR; Hendricks, DV | 1 |
| Dubash, PJ; Rege, DV | 1 |
| Wickramasinghe, SN | 1 |
| Endo, M; Goseki, N; Kando, F; Maruyama, M; Nagai, K; Shimoju, K; Wada, Y | 1 |
| Hibino, Y; Kawarabayashi, Y; Kohri, H; Tsukagoshi, S; Ueda, N | 1 |
| Muhr, C; Smits, A; Wang, JL; Zhang, ZJ | 1 |
| Hoffman, RM; Hojo, K; Ide, N; Kasai, H; Maekawa, R; Maki, H; Shono, K; Sugita, K; Uchida, N; Wada, T; Yagi, S; Yoshida, H; Yoshioka, T | 1 |
| Kubota, T | 1 |
| Araki, H; Fukushima, M; Kamiyama, Y; Shirasaka, T | 1 |
| Broët, P; Delmas-Marsalet, B; Falissard, B; Goldschmidt, E; Hoffman, RM; Luccioni, C; Machover, D; Metzger, G; Orrico, M; Schilf, A; Tan, Y; Tonetti, C; Zittoun, J | 1 |
| Cao, WX; Lin, YZ; Xiao, HB; Ye, SH; Yin, HR | 1 |
| Lewis, CM; Tarrant, GM | 1 |
| Agostini, D; Babin, E; Bequignon, A; Chesnay, E; Constans, JM; Moreau, S; Regeasse, A; Sobrio, F | 1 |
| Chen, GL; Epner, DE; Kwabi-Addo, B; Lu, S; Ren, C | 1 |
| CLARKE, CH | 1 |
| Kokkinakis, DM; Liu, X; Neuner, RD | 1 |
| Aydin, F; Kavgaci, H; Ovali, E; Ozdemir, F; Yavuz, A; Yavuz, M | 1 |
| Abrial, C; Cellarier, E; Chollet, P; Dib, M; Durando, X; Gimbergues, P; Tacca, O; Thivat, E | 1 |
| Clothier, RH; Hurst, H; Pratten, M | 1 |
| Abrial, C; Buc, E; Chollet, P; Durando, X; Farges, MC; Gillet, B; Petorin-Lesens, C; Pezet, D; Thivat, E; Vasson, MP | 1 |
| Asai, A; Doki, Y; Ishii, H; Kawamoto, K; Konno, M; Mori, M; Nishida, N; Satoh, T | 1 |
| Hoffman, RM; Stern, PH | 1 |
| Ables, G; Calcagnotto, A; Ciccarella, A; Cooper, DE; Dai, Z; Gao, X; Hsu, DS; Kirsch, DG; Liu, J; Locasale, JW; Lu, M; Mentch, SJ; Mikhael, PG; Nichenametla, SN; Reid, MA; Richie, JP; Sanderson, SM | 1 |
| Liu, C; Wang, JL; Wu, DZ; Xin, L; Yuan, YW | 1 |
| Aoki, Y; Han, Q; Hoffman, RM; Hozumi, C; Kubota, Y; Masaki, N; Tsunoda, T; Yamamoto, J | 1 |
| Barangi, M; Bouvet, M; Endo, I; Han, Q; Higuchi, T; Hoffman, RM; Igarashi, K; Kawaguchi, K; Kiyuna, T; Miyake, K; Miyake, M; Oshiro, H; Razmjooei, S; Sugisawa, N; Zhang, Z | 1 |
6 review(s) available for methionine and fluorouracil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Recent results of tRNA research.
Topics: Amino Acid Sequence; Amino Acids; Amino Acyl-tRNA Synthetases; Base Sequence; Chemical Phenomena; Chemistry; Crystallization; Enzymes; Fluorometry; Fluorouracil; Formates; Genetic Code; Magnetic Resonance Spectroscopy; Methionine; Methylation; Methyltransferases; Models, Chemical; Models, Structural; Molecular Biology; Nucleic Acid Conformation; Peptides; Ribonucleosides; Ribosomes; RNA, Neoplasm; RNA, Transfer; Spectrophotometry; Spectrum Analysis; Suppression, Genetic; X-Ray Diffraction | 1971 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deoxyuridine; Erythrocytes, Abnormal; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Homocysteine; Humans; Hypothyroidism; Lymphocyte Activation; Methionine; Pregnancy; Pregnancy Complications; Statistics as Topic; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
[Theoretical basis for low-dose CDDP/5-FU therapy].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Lung Neoplasms; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Stomach Neoplasms | 1999 |
[Methionine dependency of cancer cells: a new therapeutic approach?].
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carbon-Sulfur Lyases; Fluorouracil; Humans; Methionine; Mice; Neoplasms | 2008 |
The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).
Topics: Aminohydrolases; Antineoplastic Agents; Fluorouracil; Folic Acid; Folic Acid Antagonists; Gastrointestinal Neoplasms; Glycine Hydroxymethyltransferase; Humans; Metabolic Networks and Pathways; Metabolome; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); MicroRNAs; Mitochondria; Molecular Targeted Therapy; Multienzyme Complexes; Nucleosides; Nucleotides; Oxidoreductases Acting on CH-NH Group Donors; Purines; Reactive Oxygen Species; Serine | 2017 |
5 trial(s) available for methionine and fluorouracil
| Article | Year |
|---|---|
[Methionine-deprived amino acid solution-induced biochemical modulation of 5-FU and augmentation of the antitumor activity].
Topics: Amino Acids; Colonic Neoplasms; Fluorouracil; Humans; Methionine; Parenteral Nutrition, Total; Retinol-Binding Proteins; Stomach Neoplasms; Thymidylate Synthase | 1992 |
[Early phase II study of the combined use of AO-90 methionine-free amino acid solution and anticancer agents (5-FU and MMC) in patients with advanced and recurrent gastrointestinal cancer. AO-90 Study group].
Topics: Adult; Aged; Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Japan; Male; Methionine; Middle Aged; Mitomycin; Mitomycins; Neoplasm Recurrence, Local; Parenteral Nutrition, Total; Solutions; Stomach Neoplasms | 1990 |
[Clinical evaluation of anticancer effect of methionine-depleting total parenteral nutrition with 5-fluorouracil and/or mitomycin C].
Topics: Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Methionine; Middle Aged; Mitomycin; Parenteral Nutrition, Total; Stomach Neoplasms | 1995 |
Early response to chemotherapy in hypopharyngeal cancer: assessment with (11)C-methionine PET, correlation with morphologic response, and clinical outcome.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Female; Fluorouracil; Follow-Up Studies; Humans; Hypopharyngeal Neoplasms; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Tomography, Emission-Computed; Treatment Outcome | 2003 |
Dietary methionine restriction with FOLFOX regimen as first line therapy of metastatic colorectal cancer: a feasibility study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diet; Disease Progression; Feasibility Studies; Female; Fluorouracil; Humans; Leucovorin; Male; Methionine; Middle Aged; Models, Statistical; Monitoring, Physiologic; Neoplasm Metastasis; Organoplatinum Compounds; Treatment Outcome | 2010 |
35 other study(ies) available for methionine and fluorouracil
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Radioisotopic quantitation in microtitration plates by an autofluorographic method.
Topics: Cell Line; Densitometry; Fluorometry; Fluorouracil; Glioma; Humans; Methionine; Vincristine | 1978 |
Anti-tumor effect of L-methionine-deprived total parenteral nutrition with 5-fluorouracil administration on Yoshida sarcoma-bearing rats.
Topics: Animals; Body Weight; Cause of Death; Combined Modality Therapy; Disease Models, Animal; Evaluation Studies as Topic; Fluorouracil; Male; Methionine; Neoplasm Metastasis; Parenteral Nutrition, Total; Rats; Sarcoma, Yoshida; Survival Rate | 1991 |
Inhibited methionine incorporation in human squamous carcinomas of the oral cavity as a measure for response to 5-fluorouracil.
Topics: Carcinoma, Squamous Cell; Cell Division; Fluorouracil; Humans; Methionine; Mouth Neoplasms; Neoplasm Proteins; Protein Biosynthesis; RNA; Tumor Cells, Cultured | 1989 |
Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leukemia, Lymphoid; Methionine; Tetrahydrofolates; Thymidine | 1987 |
Effect of a high-protein-low-carbohydrate diet on toxicity and antitumor activity of 5-fluorouracil in mice.
Topics: Animals; Dietary Carbohydrates; Dietary Proteins; Female; Fluorouracil; Methionine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasms, Experimental | 1985 |
Metabolic control mechanisms in mammalian systems. Hormonal regulation of phosphofructokinase in the rat prostate and seminal vesicles.
Topics: Animals; Castration; Cycloheximide; Dactinomycin; Estradiol; Ethionine; Fluorouracil; Male; Methionine; Phosphofructokinase-1; Prostate; Protein Biosynthesis; Rats; RNA; Seminal Vesicles; Stimulation, Chemical; Testosterone; Time Factors | 1968 |
Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Electrophoresis; Fluorine; Fluorouracil; Kinetics; Liver Neoplasms; Methionine; Methylation; Neoplasms, Experimental; Rats; RNA, Ribosomal; Tritium; Uracil; Uridine | 1973 |
Methionine biosynthesis in Saccharomyces cerevisiae: mutations at the regulatory locus ETH2. I. Genetic data.
Topics: Alleles; Bromouracil; Chromosome Mapping; Enzyme Repression; Ethionine; Fluorouracil; Genes, Regulator; Genetic Linkage; Mesylates; Methionine; Mutation; Phenotype; Saccharomyces cerevisiae | 1974 |
Assay for AA-tRNA recognition by the EFTu-GTP complex of Escherichia coli.
Topics: Amino Acids; Arginine; Binding Sites; Binding, Competitive; Escherichia coli; Evaluation Studies as Topic; Fluorouracil; Guanosine Triphosphate; Kinetics; Methionine; Methods; Peptide Elongation Factors; Phenylalanine; Protein Binding; RNA, Bacterial; RNA, Transfer; Time Factors; Tryptophan; Valine | 1974 |
Effect of 5-fluorouracil on the synthesis and stability of ribosomal RNA in Saccharomyces carlsbergensis.
Topics: Carbon Isotopes; Centrifugation, Density Gradient; Fluorouracil; Methionine; Protoplasts; RNA; RNA, Ribosomal; Saccharomyces; Spectrophotometry, Ultraviolet; Time Factors | 1972 |
The effect of 5-fluorouracil and 6-thioguanine incorporation on the amino acid acceptor activity of Escherichia coli tRNA.
Topics: Alanine; Amino Acids; Carbon Isotopes; Centrifugation, Density Gradient; Escherichia coli; Fluorouracil; Glutamates; Leucine; Lysine; Methionine; Phenylalanine; RNA, Bacterial; RNA, Transfer; Thioguanine; Tyrosine; Valine | 1967 |
Incorporation of 5-fluorouracil into the transfer RNA of Escherichia coli K12W6 and its effect on the methylation of uracil.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Deoxyribonucleases; Escherichia coli; Fluorouracil; Methionine; Methylation; Nucleotides; Pseudomonas; Pyrimidines; RNA, Bacterial; RNA, Transfer; Saccharomyces; Transferases; Uracil | 1969 |
Some observations on the experimental production of acute neuroaxonal and synaptosomal dystrophy.
Topics: Animals; Axons; Brain; Cats; Citrates; Citric Acid Cycle; Cyanides; Demyelinating Diseases; Fluorine; Fluoroacetates; Fluorouracil; Methionine; Microscopy, Electron; Mitochondrial Swelling; Oxidative Phosphorylation; Pyridines; Spinal Cord; Strychnine; Synapses | 1971 |
Selective inhibition of ribosomal RNA synthesis in mammalian cells.
Topics: Animals; Antibiotics, Antineoplastic; Azaguanine; Carbon Isotopes; Centrifugation, Density Gradient; Chromatography, Paper; Culture Techniques; Dactinomycin; Fibroblasts; Fluorouracil; HeLa Cells; Methionine; Mice; Nucleosides; Protein Biosynthesis; Puromycin; Ribosomes; RNA; Sucrose; Tritium; Valine | 1968 |
Effects of cycloheximide and 5-fluorouracil on the synthesis of ribonucleic acid in yeast.
Topics: Adenine; Carbon Isotopes; Centrifugation, Density Gradient; Cycloheximide; Depression, Chemical; Fluorouracil; Methionine; Methylation; Molecular Weight; Nucleotides; Phenols; Phosphates; Phosphorus Isotopes; Ribosomes; RNA; Saccharomyces; Surface-Active Agents; Temperature | 1968 |
Effects of cycloheximide and 5-fluorouracil on formation of low-molecular-weight ribonucleic acid in yeast.
Topics: Adenine; Carbon Isotopes; Chromatography; Chromatography, Gel; Cycloheximide; Fluorouracil; Leucine; Methionine; Nucleic Acid Denaturation; Nucleotides; Phosphates; Phosphorus Isotopes; Ribosomes; RNA; RNA, Transfer; Saccharomyces; Urea | 1969 |
Chlorophyll formation in Euglena gracilis var. bacillaris: interference by analogues of purines, pyrimidines and amino acids.
Topics: Azaguanine; Chlorophyll; Citric Acid Cycle; Ethionine; Euglena; Fluorouracil; Mercaptopurine; Methionine; Purines; Thiouracil; Uracil | 1967 |
[The mechanism of potentiation of the antitumor effect of 5-fluorouracil by methionine-free intravenous amino acid solution (AO-90) in rats].
Topics: Amino Acids; Animals; Drug Synergism; Fluorouracil; Liver Neoplasms, Experimental; Male; Methionine; Parenteral Nutrition, Total; Rats; Sarcoma, Yoshida; Thymidylate Synthase | 1994 |
Synergistic inhibitory effects of interferon-alpha and 5-fluorouracil in meningioma cells in vitro.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carbon Radioisotopes; Cell Division; Drug Synergism; Female; Fluorouracil; Humans; Interferon Type I; Male; Meningeal Neoplasms; Meningioma; Methionine; Middle Aged; Neoplasm Recurrence, Local; Recombinant Proteins; Tumor Cells, Cultured | 1996 |
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carbon-Sulfur Lyases; Carcinoma, Lewis Lung; Drug Synergism; Female; Fluorouracil; Humans; Methionine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Survival Analysis; Tumor Cells, Cultured | 1998 |
Effect of consecutive lower-dose cisplatin in enhancement of 5-fluorouracil cytotoxicity in experimental tumor cells in vivo.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Synergism; Enzyme Induction; Fluorouracil; Folic Acid; Male; Methionine; Mice; Neoplasm Transplantation; Oxonic Acid; Pyridines; Rats; Sarcoma, Yoshida; Tegafur | 2000 |
Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid.
Topics: Antimetabolites, Antineoplastic; Carbon-Sulfur Lyases; Cell Division; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; Humans; Leucovorin; Methionine; Recombinant Proteins; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 2001 |
Influence of L-methionine-deprived total parenteral nutrition with 5-fluorouracil on gastric cancer and host metabolism.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; DNA, Neoplasm; Fluorouracil; Male; Methionine; Parenteral Nutrition; Rats; Rats, Wistar; S Phase; Stomach Neoplasms | 2001 |
Error theory and ageing in human diploid fibroblasts.
Topics: Amino Acids; Animals; Cell Count; Cell Death; Cellular Senescence; Deoxyribonucleases; Diploidy; Ethionine; Fibroblasts; Fluorouracil; Humans; L-Lactate Dehydrogenase; Lung; Methionine; Models, Biological; Protein Biosynthesis; Ribonucleases | 1972 |
Methionine restriction selectively targets thymidylate synthase in prostate cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Division; Fluorouracil; Folic Acid; Humans; Male; Methionine; Nucleotides; Prostatic Neoplasms; Thymidylate Synthase; Tumor Cells, Cultured | 2003 |
METHIONINE AS AN ANTIMUTAGEN IN SCHIZOSACCHAROMYCES POMBE.
Topics: Adenine; Antimutagenic Agents; Culture Media; Fluorouracil; Methionine; Mutagens; Mutation; Pharmacology; Purines; Radiation Effects; Research; Schizosaccharomyces; Ultraviolet Rays; Yeasts | 1965 |
Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Dacarbazine; Fluorouracil; Gene Expression; Gene Expression Profiling; Humans; Methionine; Neoplasm Proteins; O(6)-Methylguanine-DNA Methyltransferase; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Phosphorylation; Retinoblastoma Protein; Signal Transduction; Temozolomide; Transforming Growth Factor beta | 2005 |
Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Combined Modality Therapy; Farnesyltranstransferase; Fluorouracil; Humans; Methionine; Radiation Tolerance | 2005 |
An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial.
Topics: Acetone; alpha-Chlorohydrin; Animal Testing Alternatives; Animals; Cell Count; Cell Culture Techniques; Cell Differentiation; Cell Separation; Cell Survival; Cells, Cultured; Chick Embryo; Culture Media; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Stem Cells; Ethionine; Fluorouracil; Indicators and Reagents; Methionine; Myocardial Contraction; Myocytes, Cardiac; Neutral Red; Organic Chemicals; Oxazines; Sulfanilamide; Sulfanilamides; Sulfisoxazole; Teratogens; Time Factors; Toxicity Tests; Uracil; Xanthenes | 2009 |
Dietary Methionine Restriction-Based Cancer Chemotherapy in Rodents.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Cisplatin; Coculture Techniques; Diet; Doxorubicin; Ethionine; Fluorouracil; Humans; Male; Methionine; Mice, Nude; Neoplasm Metastasis; Neoplasms; Parenteral Nutrition; Rats; Sarcoma, Yoshida; Vincristine | 2019 |
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Disease Models, Animal; Female; Fluorouracil; Genes, p53; Genes, ras; Healthy Volunteers; Humans; Male; Metabolomics; Methionine; Mice; Middle Aged; Mutation; Proof of Concept Study; Sarcoma; Soft Tissue Neoplasms; Sulfur; Treatment Outcome | 2019 |
Methionine restriction enhances the chemotherapeutic sensitivity of colorectal cancer stem cells by miR-320d/c-Myc axis.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Methionine; Mice; MicroRNAs; Neoplastic Stem Cells | 2022 |
Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Carbon-Sulfur Lyases; Disease Models, Animal; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Methionine; Mice; Mice, Nude; Oxaliplatin; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2022 |
Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer.
Topics: Animals; Carbon-Sulfur Lyases; Fluorouracil; Humans; Methionine; Mice; Recombinant Proteins; Stomach Neoplasms | 2023 |