Page last updated: 2024-08-17

methionine and alpha-synuclein

methionine has been researched along with alpha-synuclein in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (32.26)	29.6817
2010's	18 (58.06)	24.3611
2020's	3 (9.68)	2.80

Authors

Authors	Studies
Fink, AL; Glaser, CB; Goers, J; Souillac, PO; Uversky, VN; Yamin, G	1
Fink, AL; Goers, J; Hokenson, MJ; Munishkina, LA; Uversky, VN; Yamin, G	1
Fink, AL; Glaser, CB; Uversky, VN; Yamin, G	1
Giasson, BI; Hodara, R; Ischiropoulos, H; Lee, VM; Norris, EH; Trojanowski, JQ; Xu, S	1
Grzonka, Z; Jankowska, E; Kowalik-Jankowska, T; Rajewska, A; Wiśniewska, K	1
Bras, J; Calado, A; Dias, M; Guerreiro, R; Hardy, J; Januario, C; Morgadinho, A; Oliveira, C; Ribeiro, M; Semedo, C; Singleton, A	1
Grzonka, Z; Jankowska, E; Kowalik-Jankowska, T; Rajewska, A	1
Ali, FE; Barnham, KJ; Cappai, R; Fodero-Tavoletti, MT; Galatis, D; Hill, AF; Leong, SL; Masters, CL; Perez, K; Pham, CL	1
Cookson, MR; Fredenburg, RA; Grammatopoulos, TN; Lansbury, PT; Liu, Y; Liu, Z; Logan, T; Meray, RK	1
Moore, DS; Moskovitz, J; Oien, DB; Shinogle, HE	1
Di Monte, DA; Fink, AL; Long, C; Reaney, SH; Uversky, VN; Zhou, W	1
Lee, JC; Lucas, HR	1
Barnham, KJ; Cappai, R; Curtain, CC; Drew, SC; Knott, RB; Masters, CL; Perez, KA; Pham, CL; Rekas, A; Sokolova, A	1
Cui, ZJ; Han, ZQ; Li, ZY	1
Sharov, VS; Surgucheva, I; Surguchov, A	1
Bax, A; Chen, J; Levine, RL; Maltsev, AS	1
Horikoshi, Y; Ito, S; Kikuchi, D; Matsura, T; Mochida, S; Nakashima, K; Nakaso, K; Tajima, N; Teraoka, M; Yamashita, A	1
Alvarez-Castelao, B; Castaño, JG; Goethals, M; Vandekerckhove, J	1
Carmo-Gonçalves, P; Cortines, J; Follmer, C; Pinheiro, AS; Romão, L	1
Bubacco, L; Casella, L; De Ricco, R; Dell'Acqua, S; Gaggelli, E; Mangani, S; Valensin, D; Valensin, G	1
Bekei, B; Binolfi, A; Kosten, J; Limatola, A; Rose, HM; Selenko, P; Stuiver, M; Theillet, FX; van Rossum, M; Verzini, S	1
Arcos-López, T; Fernández, CO; González, FJ; Quintanar, L; Rodríguez, EE; Trujano-Ortiz, LG; Vela, A	1
Bellotti, V; De Franceschi, G; de Laureto, PP; Fecchio, C; Proukakis, C; Schapira, AHV; Sharon, R	1
de Moraes, MC; Fernandes, L; Foguel, D; Grimster, NP; Kelly, JW; Magalhães, AV; Moraes, N; Palhano, FL; Romão, L; Sagrillo, FS	1
Deng, Y; Jiang, B; Maupin-Furlow, JA; Moskovitz, J; Rankin, CL; Richter, ML; Toyo-Oka, K	1
Delgado Ocaña, S; Fernández, CO; Garro, HA; Gentile, I; Gonzalez, N; Griesinger, C; Menacho Márquez, M; Quintanar, L; Sambrotta, L; Schibich, D; Strohäker, T; Zweckstetter, M	1
Carmo-Gonçalves, P; Cortines, JR; do Nascimento, LA; Eliezer, D; Follmer, C; Romão, L	1
Cerboni, L; De Palma, A; Grandori, R; Konijnenberg, A; Legname, G; Mauri, P; Moons, R; Narkiewicz, J; Natalello, A; Ponzini, E; Rossi, R; Santambrogio, C; Sobott, F	1
Adrover, M; Frau, J; Ortega-Castro, J; Ramis, R; Vilanova, B	1
Castañeda-Hernández, G; Fernández, CO; González, FJ; Quintanar, L; Ríos, A; Rodríguez, EE; Trujano-Ortiz, LG; Villegas, A	1
Adrover, M; Frau, J; Uceda, AB; Vilanova, B	1

Reviews

2 review(s) available for methionine and alpha-synuclein

Article	Year
Methionine oxidation, alpha-synuclein and Parkinson's disease. Biochimica et biophysica acta, 2005, Jan-17, Volume: 1703, Issue:2 Topics: alpha-Synuclein; Humans; Methionine; Nerve Tissue Proteins; Parkinson Disease; Synucleins	2005
Modulating protein activity and cellular function by methionine residue oxidation. Amino acids, 2012, Volume: 43, Issue:2 Topics: alpha-Synuclein; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Apolipoproteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Humans; Methionine; Molecular Sequence Data; Oxidation-Reduction; Potassium Channels; Prions; Protein Multimerization; Reactive Oxygen Species	2012

Article

Year

Methionine oxidation, alpha-synuclein and Parkinson's disease.

Biochimica et biophysica acta, 2005, Jan-17, Volume: 1703, Issue:2

Topics: alpha-Synuclein; Humans; Methionine; Nerve Tissue Proteins; Parkinson Disease; Synucleins

2005

Modulating protein activity and cellular function by methionine residue oxidation.

Amino acids, 2012, Volume: 43, Issue:2

Topics: alpha-Synuclein; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Apolipoproteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Humans; Methionine; Molecular Sequence Data; Oxidation-Reduction; Potassium Channels; Prions; Protein Multimerization; Reactive Oxygen Species

2012

Other Studies

29 other study(ies) available for methionine and alpha-synuclein

Article	Year
Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro. FEBS letters, 2002, Apr-24, Volume: 517, Issue:1-3 Topics: alpha-Synuclein; Escherichia coli; Humans; Hydrogen-Ion Concentration; Methionine; Nerve Tissue Proteins; Oxidation-Reduction; Protein Binding; Protein Folding; Protein Structure, Secondary; Synucleins	2002
Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein. Biochemistry, 2004, Apr-20, Volume: 43, Issue:15 Topics: alpha-Synuclein; Amino Acid Substitution; Circular Dichroism; Fluorescence Polarization; Humans; Leucine; Light; Methionine; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Oxidation-Reduction; Protein Structure, Secondary; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Synucleins; Zinc	2004
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22 Topics: alpha-Synuclein; Amino Acid Motifs; Circular Dichroism; DNA, Complementary; Dopamine; Histidine; Humans; Indolequinones; Methionine; Microscopy, Atomic Force; Microscopy, Electron; Mutagenesis; Mutation; Nerve Tissue Proteins; Oxidative Stress; Oxygen; Parkinson Disease; Peptides; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Synucleins; Time Factors; Tyrosine	2005
Products of Cu(II)-catalyzed oxidation of the N-terminal fragments of alpha-synuclein in the presence of hydrogen peroxide. Journal of inorganic biochemistry, 2006, Volume: 100, Issue:10 Topics: alpha-Synuclein; Amino Acid Sequence; Binding Sites; Chromatography, High Pressure Liquid; Copper; Hydrogen Peroxide; Methionine; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2006
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2. BMC neurology, 2008, Jan-22, Volume: 8 Topics: Aged; alpha-Synuclein; DNA Mutational Analysis; Exons; Family Health; Female; Genetic Predisposition to Disease; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Methionine; Middle Aged; Mutation; Parkinson Disease; Portugal; Protein Kinases; Protein Serine-Threonine Kinases; Threonine; Ubiquitin-Protein Ligases	2008
Products of Cu(II)-catalyzed oxidation of alpha-synuclein fragments containing M1-D2 and H50 residues in the presence of hydrogen peroxide. Dalton transactions (Cambridge, England : 2003), 2008, Feb-14, Issue:6 Topics: alpha-Synuclein; Amino Acid Sequence; Binding Sites; Catalysis; Cations, Divalent; Chromatography, High Pressure Liquid; Copper; Histidine; Hydrogen Peroxide; Hydrogen-Ion Concentration; Lysine; Methionine; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfones	2008
Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation. Free radical biology & medicine, 2009, May-15, Volume: 46, Issue:10 Topics: alpha-Synuclein; Amino Acid Motifs; Chromatography, High Pressure Liquid; Cloning, Molecular; Dopamine; Humans; Lewy Bodies; Methionine; Mutagenesis, Site-Directed; Neurons; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Peptides; Protein Binding; Protein Multimerization; Solubility; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2009
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America, 2009, Mar-24, Volume: 106, Issue:12 Topics: alpha-Synuclein; Animals; Brain; Cell Line, Tumor; Cell Membrane; Chlorocebus aethiops; COS Cells; Cysteine; Endoplasmic Reticulum; Humans; Intracellular Membranes; Methionine; Mice; Neurons; Parkinson Disease; Prenylation; Proteasome Endopeptidase Complex; Protein Binding; Ubiquitin Thiolesterase	2009
Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells. Journal of molecular neuroscience : MN, 2009, Volume: 39, Issue:3 Topics: alpha-Synuclein; Amino Acid Sequence; Casein Kinase II; Gene Expression Regulation, Enzymologic; Gene Knockout Techniques; Methionine; Methionine Sulfoxide Reductases; Mutation; Neurofibrils; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Parkinson Disease; Saccharomyces cerevisiae; Up-Regulation	2009
Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions. Biochimica et biophysica acta, 2010, Volume: 1802, Issue:3 Topics: alpha-Synuclein; Amino Acid Substitution; Chromatography, High Pressure Liquid; Circular Dichroism; Humans; Hydrogen Peroxide; Methionine; Mutagenesis, Site-Directed; Mutation; Oxidants; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2010
Effect of dioxygen on copper(II) binding to alpha-synuclein. Journal of inorganic biochemistry, 2010, Volume: 104, Issue:3 Topics: alpha-Synuclein; Amino Acid Sequence; Binding Sites; Circular Dichroism; Copper; Methionine; Molecular Conformation; Molecular Sequence Data; Oxidation-Reduction; Oxygen; Peptides; Protein Binding; Tryptophan	2010
The structure of dopamine induced alpha-synuclein oligomers. European biophysics journal : EBJ, 2010, Volume: 39, Issue:10 Topics: alpha-Synuclein; Amyloid; Benzoquinones; Circular Dichroism; Cross-Linking Reagents; Dopamine; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Melanins; Methionine; Oxidation-Reduction; Parkinson Disease; Protein Folding; Protein Multimerization; Protein Structure, Secondary; Scattering, Small Angle; Ultracentrifugation	2010
γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells. Biochemistry, 2012, Jun-12, Volume: 51, Issue:23 Topics: alpha-Synuclein; Aniline Compounds; Animals; Antibodies; Astrocytes; Benzylidene Compounds; beta-Cyclodextrins; Cell Line; gamma-Synuclein; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Mass Spectrometry; Methionine; Models, Molecular; Protein Binding; Protein Conformation; Protein Folding; Rats; T-Lymphocytes	2012
Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates. Journal of the American Chemical Society, 2013, Feb-27, Volume: 135, Issue:8 Topics: alpha-Synuclein; Magnetic Resonance Spectroscopy; Methionine; Oxidation-Reduction	2013
Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein. PloS one, 2013, Volume: 8, Issue:2 Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Dopamine; Gene Expression; Humans; Hydrogen Peroxide; Methionine; Oxidation-Reduction; Parkinson Disease; PC12 Cells; Point Mutation; Rats; Recombinant Proteins	2013
Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines. Biochimica et biophysica acta, 2014, Volume: 1843, Issue:2 Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Humans; Hydrogen Peroxide; Immunoblotting; Methionine; Methionine Sulfoxide Reductases; Mice; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Peptides; Proteasome Endopeptidase Complex; Protein Binding; Protein Interaction Mapping; Protein Structure, Quaternary; Protein Subunits; Proteolysis; Rats; Silver Staining	2014
UV-induced selective oxidation of Met5 to Met-sulfoxide leads to the formation of neurotoxic fibril-incompetent α-synuclein oligomers. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2014, Volume: 21, Issue:3 Topics: alpha-Synuclein; Animals; Circular Dichroism; Escherichia coli; Gene Expression; Humans; Hydrogen Peroxide; Methionine; Mice; Neurons; Oxidation-Reduction; Oxidative Stress; Primary Cell Culture; Protein Aggregates; Recombinant Proteins; Solutions; Ultraviolet Rays	2014
Differences in the binding of copper(I) to α- and β-synuclein. Inorganic chemistry, 2015, Jan-05, Volume: 54, Issue:1 Topics: alpha-Synuclein; Amino Acid Sequence; beta-Synuclein; Cations, Monovalent; Chemical Precipitation; Copper; Humans; Lysine; Methionine; Molecular Sequence Data; Mutation; Peptides; Protein Binding; Solid-Phase Synthesis Techniques; Solutions	2015
Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites. Nature communications, 2016, Jan-25, Volume: 7 Topics: alpha-Synuclein; Amino Acid Motifs; Humans; Magnetic Resonance Spectroscopy; Methionine; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Phosphorylation; Serine	2016
Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2016, Volume: 21, Issue:5-6 Topics: alpha-Synuclein; Copper; Humans; Kinetics; Methionine; Molecular Structure	2016
α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection. The Journal of biological chemistry, 2017, 04-28, Volume: 292, Issue:17 Topics: alpha-Synuclein; Arachidonic Acid; Binding Sites; Brain; Circular Dichroism; Docosahexaenoic Acids; Fatty Acids, Unsaturated; Humans; Lipid Metabolism; Lysine; Mass Spectrometry; Methionine; Neuroprotection; Oxygen; Parkinson Disease; Protein Structure, Secondary; Trypsin	2017
An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils. ACS chemical neuroscience, 2017, 08-16, Volume: 8, Issue:8 Topics: alpha-Synuclein; Amyloid beta-Peptides; Animals; Catechin; Cell Survival; Cells, Cultured; Chickens; Dopaminergic Neurons; HEK293 Cells; Humans; Lysine; Methionine; Mice; Micrococcus luteus; Microtubule-Associated Proteins; Muramidase; Neuroprotective Agents; Oxidation-Reduction; Peptide Fragments; Protein Aggregation, Pathological; Quinones; Tyrosine 3-Monooxygenase	2017
Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain. Free radical biology & medicine, 2018, Volume: 129 Topics: 14-3-3 Proteins; alpha-Synuclein; Amino Acid Sequence; Animals; Archaeal Proteins; Binding, Competitive; Brain; Brain Chemistry; Dopamine; Lysine; Methionine; Methionine Sulfoxide Reductases; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Isoforms; Protein Processing, Post-Translational; Serine; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination	2018
Interaction of Cu(i) with the Met-X Metallomics : integrated biometal science, 2018, 10-17, Volume: 10, Issue:10 Topics: alpha-Synuclein; Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Copper; Humans; Ligands; Magnetic Resonance Spectroscopy; Methionine; Models, Molecular; Protein Binding; Protein Conformation	2018
Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein. Biochemical and biophysical research communications, 2018, 10-20, Volume: 505, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Synuclein; Animals; Cell Survival; Cells, Cultured; Humans; Hydrogen Peroxide; Methionine; Mice; Mutation; Neurons; Oxidants; Oxidation-Reduction; Protein Multimerization; Protein Processing, Post-Translational	2018
Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure. The Journal of biological chemistry, 2019, 04-05, Volume: 294, Issue:14 Topics: alpha-Synuclein; Catechin; Humans; Lewy Bodies; Methionine; Oxidation-Reduction; Parkinson Disease; Protein Aggregates; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary	2019
Cu International journal of biological macromolecules, 2021, Feb-01, Volume: 169 Topics: alpha-Synuclein; Binding Sites; Calcium; Catalysis; Copper; Humans; Intrinsically Disordered Proteins; Methionine; Molecular Dynamics Simulation; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Protein Conformation	2021
Comparing the copper binding features of alpha and beta synucleins. Journal of inorganic biochemistry, 2022, Volume: 229 Topics: alpha-Synuclein; Amino Acid Sequence; beta-Synuclein; Binding Sites; Copper; Histidine; Methionine; Protein Binding	2022
On the effect of methionine oxidation on the interplay between α-synuclein and synaptic-like vesicles. International journal of biological macromolecules, 2023, Feb-28, Volume: 229 Topics: alpha-Synuclein; Humans; Methionine; Micelles; Parkinson Disease; Racemethionine; Synaptic Vesicles	2023