methionine has been researched along with 5-methyltetrahydrofolate in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (42.19) | 18.7374 |
| 1990's | 20 (31.25) | 18.2507 |
| 2000's | 9 (14.06) | 29.6817 |
| 2010's | 6 (9.38) | 24.3611 |
| 2020's | 2 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Banerjee, RV; González, JC; Huang, S; Matthews, RG; Sumner, JS | 1 |
| Brot, N; Cai, XY; Jakubowski, H; Redfield, B; Weissbach, H; Zaleski, B | 1 |
| Hipwell, SE; Liteplo, RG; Lue-Shing, H; Rosenblatt, DS; Sillaots, S | 1 |
| Hyland, K; Smith, I; Surtees, R | 1 |
| Hyland, K; Surtees, R | 2 |
| Liteplo, RG | 1 |
| Baker, DH; Czarnecki, GL | 1 |
| Schalinske, KL; Steele, RD | 1 |
| Chanarin, I; Deacon, R; Lumb, M; Perry, J | 3 |
| Bottiglieri, T; Chanarin, I; Deacon, R; Lumb, M; Perry, J | 1 |
| Cook, RJ; Horne, DW; Wagner, C | 1 |
| Chanarin, I; Deacon, R; Lumb, M; Muir, M; Perry, J | 1 |
| Long, M; Scott, J; Weir, D | 1 |
| Bertino, JR; Coronnello, M; Criscuoli, L; Gualtieri, M; Mazzei, T; Mini, E; Periti, P | 1 |
| Kvinnsland, S; Refsum, H; Ueland, PM | 1 |
| Pristoupil, TI; Pristoupilová, K | 1 |
| Cartier, PH; Christa, L; Kersual, J; Pérignon, JL | 1 |
| Barak, AJ; Beckenhauer, HC; Tuma, DJ | 2 |
| Dinn, JJ; Scott, JM; Weir, DG; Wilson, P | 1 |
| Barak, AJ; Tuma, DJ | 1 |
| Shane, B; Stokstad, EL | 1 |
| Bishop, AJ; Cooper, BA; Haworth, JC; Rosenblatt, DS; Schroeder, ML; Schuh, S; Seargeant, LE | 1 |
| Tisdale, MJ | 1 |
| Makar, AB; Tephly, TR | 1 |
| Wickramasinghe, SN | 1 |
| Drummond, JT; Matthews, RG | 1 |
| Asawamahasakda, W; Yuthavong, Y | 1 |
| Angst, CP; Browne, G; Fowler, B; Frick, G; Haefeli, WE; Loehrer, FM | 1 |
| Coulson, WF; Henning, SM; Swendseid, ME | 1 |
| Banerjee, R; Chen, Z; Gulati, S | 1 |
| Fluhr, K; Goulding, CW; Huang, S; Jarrett, JT; Matthews, RG | 1 |
| Angst, CP; Fowler, B; Haefeli, WE; Loehrer, FM; Schwab, R | 1 |
| Brunone, M; De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Blanco, J; Coque, JJ; Martin, JF | 1 |
| Clelland, J; Hann, I; Surtees, R | 1 |
| Watkins, D | 1 |
| Bottiglieri, T; Charles, HC; Gray, L; Hyland, K; Jaeken, J; Kahler, SG; Lazeyras, F; Van Hove, JL; Zeisel, SH | 1 |
| Appling, DR; Kastanos, EK; Raymond, RK | 1 |
| Finkelstein, JD | 1 |
| Bonham, JR; Lee, PJ; Lewis, MJ; McDowell, IF; Moat, SJ; Powers, HJ; Pullin, CH; Wilson, JF | 1 |
| Fenech, M; Wang, X | 1 |
| Bandarian, V; Ludwig, ML; Matthews, RG | 1 |
| Bagley, PJ; Lathrop Stern, L; Nadeau, M; Selhub, J; Shane, B; Shih, V | 1 |
| KISLIUK, RL | 1 |
| BUCHANAN, JM; ROSENTHAL, S; SMITH, LC | 1 |
| WOLFE, RS; WOOD, JM | 1 |
| Ozias, MK; Schalinske, KL | 1 |
| Dumas, R; Ferrer, JL; Ravanel, S; Robert, M | 1 |
| Budu, P; Nijhout, HF; Reed, MC; Ulrich, CM | 1 |
| Miller, AL | 1 |
| Beverley, SM; Vickers, TJ | 1 |
| Alpert, JE; Arning, E; Bottiglieri, T; Fava, M; Mischoulon, D; Papakostas, GI | 1 |
| Chittur, SV; Mattocks, DA; Mohney, R; Orentreich, DS; Orentreich, N; Perrone, CE; Plummer, JD; Vignola, K | 1 |
| Hayakawa, T; Isa, Y; Nakagawa, T; Yamamoto, K | 1 |
| Bertino, JR; Chaturvedi, S; Hoffman, RM | 1 |
| Alberto, JM; Battaglia-Hsu, SF; Chéry, C; Gauchotte, G; Guéant, JL; Hergalant, S; Namour, F; Quéré, M; Rouyer, P; Zgheib, R | 1 |
| Arkin, AP; Deutschbauer, AM; Price, MN | 1 |
| Annibal, A; Antebi, A; Auler, MMK; Grönke, S; Latza, C; Partridge, L; Schonewolff, MF; Tam, H; Tharyan, RG | 1 |
10 review(s) available for methionine and 5-methyltetrahydrofolate
| Article | Year |
|---|---|
Cobalamin-folate interrelations.
Topics: Anemia, Megaloblastic; Animals; Central Nervous System Diseases; Coenzymes; Folic Acid; Folic Acid Deficiency; Formates; Humans; Methionine; Models, Biological; Tetrahydrofolates; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1989 |
Cobalamin-folate interrelations: a critical review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central Nervous System; Deoxyuridine; Disease Models, Animal; Drug Interactions; Enzyme Activation; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Liver; Methionine; Methylmalonyl-CoA Mutase; Nitrous Oxide; Oxidation-Reduction; Pteroylpolyglutamic Acids; Purines; Serine; Tetrahydrofolates; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency | 1985 |
Nitrous oxide, vitamin B12 deficiency and the methyl folate trap.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Humans; Liver; Macaca fascicularis; Methionine; Methylmalonyl-CoA Mutase; Nervous System Diseases; Nitrous Oxide; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 Deficiency | 1982 |
Betaine, metabolic by-product or vital methylating agent?
Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates | 1983 |
The interrelationships among folate, vitamin B12, and methionine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; DNA; Drug Interactions; Folic Acid; Formates; Histidine; Humans; Megaloblasts; Methionine; Nitrous Oxide; Peptide Synthases; Pteroylpolyglutamic Acids; Purines; Serine; Tetrahydrofolates; Thymidine Monophosphate; Thyroid Gland; Vitamin B 12 | 1983 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deoxyuridine; Erythrocytes, Abnormal; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Homocysteine; Humans; Hypothyroidism; Lymphocyte Activation; Methionine; Pregnancy; Pregnancy Complications; Statistics as Topic; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
Pathways and regulation of homocysteine metabolism in mammals.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Homocysteine; Isoenzymes; Kinetics; Mammals; Methionine; Methionine Adenosyltransferase; Organ Specificity; Oxidation-Reduction; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tetrahydrofolates | 2000 |
The methylation, neurotransmitter, and antioxidant connections between folate and depression.
Topics: Antioxidants; Biopterins; Depression; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Methylation; Neurotransmitter Agents; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2008 |
Folate metabolic pathways in Leishmania.
Topics: Amino Acid Oxidoreductases; Animals; Carrier Proteins; Folic Acid; Host-Parasite Interactions; Iron-Sulfur Proteins; Leishmania; Metabolic Networks and Pathways; Methionine; Multienzyme Complexes; Pteridines; Purines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Transferases | 2011 |
Exploiting methionine restriction for cancer treatment.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Humans; Methionine; Neoplasms; Purine-Nucleoside Phosphorylase; Tetrahydrofolates; Treatment Outcome; Tumor Cells, Cultured | 2018 |
3 trial(s) available for methionine and 5-methyltetrahydrofolate
| Article | Year |
|---|---|
Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia.
Topics: Erythrocyte Membrane; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Methyltransferases; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uremia | 1997 |
Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies.
Topics: Antidotes; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Demyelinating Diseases; Drug Interactions; Humans; Infant; Leucovorin; Methionine; Methotrexate; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Tetrahydrofolates | 1998 |
Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder.
Topics: Biological Availability; Depressive Disorder, Major; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Homocysteine; Humans; Male; Methionine; Middle Aged; Psychiatric Status Rating Scales; S-Adenosylhomocysteine; S-Adenosylmethionine; Selective Serotonin Reuptake Inhibitors; Tetrahydrofolates | 2012 |
51 other study(ies) available for methionine and 5-methyltetrahydrofolate
| Article | Year |
|---|---|
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alkylation; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Cysteine; Escherichia coli; Homocysteine; Iodoacetamide; Methionine; Molecular Sequence Data; Recombinant Proteins; Restriction Mapping; Tetrahydrofolates; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Trypsin; Vitamin B 12 | 1992 |
Role of the metF and metJ genes on the vitamin B12 regulation of methionine gene expression: involvement of N5-methyltetrahydrofolic acid.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Enzyme Repression; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Methionine; Tetrahydrofolates; Trimethoprim; Vitamin B 12 | 1992 |
Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Division; Homocysteine; Humans; Melanoma; Methionine; Phenotype; Tetrahydrofolates; Tumor Cells, Cultured; Vitamin B 12 | 1991 |
Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection.
Topics: Biopterins; Child, Preschool; Encephalitis; HIV Seropositivity; Humans; Infant; Methionine; Methylation; Neopterin; S-Adenosylmethionine; Tetrahydrofolates | 1990 |
Cerebrospinal fluid concentrations of S-adenosylmethionine, methionine, and 5-methyltetrahydrofolate in a reference population: cerebrospinal fluid S-adenosylmethionine declines with age in humans.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Methionine; S-Adenosylmethionine; Tetrahydrofolates | 1990 |
Reversion to a homocysteine-responsive phenotype in a human melanoma cell line is associated with diminished growth potential and increased methionine biosynthesis.
Topics: Adenosine; Cell Division; Culture Media; Deoxyadenosines; Homocysteine; Humans; Melanoma, Experimental; Methionine; Phenotype; S-Adenosylmethionine; Tetrahydrofolates; Thionucleosides; Tumor Cells, Cultured | 1990 |
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans.
Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine | 1990 |
Transmethylation of homocysteine to methionine: efficiency in the rat and chick.
Topics: Animals; Betaine; Body Weight; Chickens; Choline; Diet; Homocysteine; Male; Methionine; Methylation; Rats; Rats, Inbred Strains; Sarcosine; Tetrahydrofolates | 1985 |
Quantitation of carbon flow through the hepatic folate-dependent one-carbon pool in rats.
Topics: Animals; Biological Transport; Carbon; Homocysteine; Liver; Male; Methionine; Rats; Rats, Inbred Strains; Serine; Tetrahydrofolates; Time Factors | 1989 |
Regulation of 5-methyltetrahydrofolate synthesis.
Topics: Animals; Liver; Methionine; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1989 |
Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats.
Topics: Animals; Formyltetrahydrofolates; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates; Vitamin B 12 | 1989 |
Effect of dietary methyl group deficiency on folate metabolism in rats.
Topics: Amino Acids; Animals; Choline Deficiency; Chromatography, High Pressure Liquid; Diet; Folic Acid; Leucovorin; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred F344; Tetrahydrofolates | 1989 |
Source of methyl groups in brain and nerve tissue in the rat.
Topics: Animals; Biological Transport; Brain; Leucine; Methionine; Methylation; Rats; Rats, Inbred Strains; Spinal Cord; Tetrahydrofolates | 1989 |
Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leukemia, Lymphoid; Methionine; Tetrahydrofolates; Thymidine | 1987 |
In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.
Topics: Adenosine; Animals; Betaine; Carbon Dioxide; Deoxyadenosines; Formyltetrahydrofolates; Glycine; Liver; Male; Methionine; Oxidation-Reduction; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Serine; Tetrahydrofolates; Thionucleosides; Time Factors | 1988 |
Acute and long-term effects of high-dose methotrexate treatment on homocysteine in plasma and urine.
Topics: Adolescent; Adult; Cells, Cultured; Female; Homocysteine; Humans; Male; Methionine; Methotrexate; Middle Aged; Tetrahydrofolates | 1986 |
[An explanation of the metabolic relation of vitamin B12, folates and methionine using oxidative transmethylase].
Topics: Animals; Folic Acid; Humans; Methionine; Models, Chemical; Tetrahydrofolates; Vitamin B 12 | 1986 |
Metabolism of 5'-methylthioadenosine in methionine-dependent and methionine-independent cells.
Topics: Adenosine; Cell Cycle; Cell Line; Deoxyadenosines; Humans; Methionine; Tetrahydrofolates; Thionucleosides | 1986 |
Ethanol, the choline requirement, methylation and liver injury.
Topics: Animals; Betaine; Choline; Ethanol; Folic Acid; Homocysteine; Liver; Methionine; Methylation; Rats; Tetrahydrofolates | 1985 |
Pathogenesis of subacute combined degeneration: a result of methyl group deficiency.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Humans; Macaca fascicularis; Methionine; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; Tetrahydrofolates; Vitamin B 12 | 1981 |
Methotrexate hepatotoxicity.
Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides | 1984 |
Methionine can open the methyl folate trap.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Methionine; Nitrous Oxide; Rats; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
Homocystinuria and megaloblastic anemia responsive to vitamin B12 therapy. An inborn error of metabolism due to a defect in cobalamin metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Metabolism, Inborn Errors; Anemia, Macrocytic; Anemia, Megaloblastic; Cobamides; Fibroblasts; Homocystinuria; Humans; Hydroxocobalamin; Infant, Newborn; Male; Methionine; Propionates; Tetrahydrofolates; Vitamin B 12 | 1984 |
Utilization of preformed and endogenously synthesized methionine by cells in tissue culture.
Topics: Animals; Bone Marrow; Cell Division; Cell Line; Culture Media; Embryo, Mammalian; Homocysteine; Humans; Lung; Methionine; Mice; Neoplasms, Experimental; Tetrahydrofolates | 1984 |
Effect of nitrous oxide and methionine treatments on hepatic S-adenosylmethionine and methylation reactions in the rat.
Topics: Animals; Formates; Liver; Male; Methionine; Methylation; Nitrous Oxide; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Tetrahydrofolates | 1983 |
Nitrous oxide inactivation of cobalamin-dependent methionine synthase from Escherichia coli: characterization of the damage to the enzyme and prosthetic group.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Sequence; Binding Sites; Electrochemistry; Escherichia coli; Homocysteine; Methionine; Molecular Sequence Data; Nitrous Oxide; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; S-Adenosylmethionine; Tetrahydrofolates; Trypsin; Vitamin B 12 | 1994 |
The methionine synthesis cycle and salvage of methyltetrahydrofolate from host red cells in the malaria parasite (Plasmodium falciparum).
Topics: Animals; Erythrocytes; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Oxidoreductases Acting on CH-NH Group Donors; Plasmodium chabaudi; Plasmodium falciparum; Plasmodium knowlesi; Serine; Tetrahydrofolates | 1993 |
Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy humans.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Kinetics; Male; Methionine; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1996 |
Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Liver Neoplasms, Experimental; Male; Methionine; NAD; Niacin; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred F344; Tetrahydrofolates | 1997 |
Methionine synthase from pig liver.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Radioisotopes; Chromatography; Chromatography, Gel; Homocysteine; Hydrogen-Ion Concentration; Liver; Methionine; Molecular Weight; Spectrophotometry; Swine; Tetrahydrofolates | 1997 |
Purification and assay of cobalamin-dependent methionine synthase from Escherichia coli.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Carbon Radioisotopes; Escherichia coli; Homocysteine; Methionine; Spectrophotometry; Tetrahydrofolates; Vitamin B 12 | 1997 |
Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Administration, Oral; Adult; Female; Homocysteine; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Reference Values; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates | 1997 |
The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: disruption of the 5,10-methylenetetrahydrofolate reductase gene leads to methionine auxotrophy.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Chromosome Mapping; Cloning, Molecular; DNA, Bacterial; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genetic Complementation Test; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Molecular Sequence Data; Mutagenesis, Insertional; Open Reading Frames; Oxidoreductases Acting on CH-NH Group Donors; Plasmids; Promoter Regions, Genetic; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; RNA, Messenger; Salmonella typhimurium; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Single-Strand Specific DNA and RNA Endonucleases; Streptomyces; Tetrahydrofolates; Trans-Activators; Transcription, Genetic; Transformation, Genetic | 1998 |
Cobalamin metabolism in methionine-dependent human tumour and leukemia cell lines.
Topics: Carbon Radioisotopes; Culture Media; Humans; Leukemia; Melanoma; Methionine; Neoplasms; Propionates; Tetrahydrofolates; Tumor Cells, Cultured; Vitamin B 12 | 1998 |
One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.
Topics: Amino Acid Metabolism, Inborn Errors; Benzoic Acid; Brain Diseases; Choline; Coma; Female; Glycine; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methionine; Methylation; Phosphatidylcholines; S-Adenosylmethionine; Seizures; Serine; Tetrahydrofolates | 1998 |
Saccharomyces cerevisiae expresses two genes encoding isozymes of methylenetetrahydrofolate reductase.
Topics: Amino Acid Sequence; Base Sequence; Cloning, Molecular; Enzyme Activation; Escherichia coli; Gene Deletion; Gene Expression Profiling; Genes, Fungal; Genetic Complementation Test; Humans; Isoenzymes; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Physical Chromosome Mapping; Recombinant Proteins; RNA, Messenger; Saccharomyces cerevisiae; Sequence Alignment; Tetrahydrofolates; Vitamin K | 1999 |
Vitamin C therapy ameliorates vascular endothelial dysfunction in treated patients with homocystinuria.
Topics: Adult; Ascorbic Acid; Blood Flow Velocity; Blood Pressure; Brachial Artery; Endothelium, Vascular; Female; Heart Rate; Homocystine; Homocystinuria; Humans; Male; Methionine; Nitric Oxide; Nitroglycerin; Tetrahydrofolates; Vasodilation | 2002 |
A comparison of folic acid and 5-methyltetrahydrofolate for prevention of DNA damage and cell death in human lymphocytes in vitro.
Topics: Adult; Biological Availability; Carrier Proteins; Cell Division; Cells, Cultured; Choline; Chromosome Breakage; Chromosomes, Human; Deoxyuracil Nucleotides; DNA; DNA Damage; DNA Methylation; DNA Replication; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Lymphocyte Activation; Lymphocytes; Membrane Transport Proteins; Methionine; Micronucleus Tests; Middle Aged; Oxidation-Reduction; Phytohemagglutinins; Prodrugs; Receptors, Cell Surface; Reduced Folate Carrier Protein; Tetrahydrofolates; Uracil | 2003 |
Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Substitution; Catalysis; Escherichia coli; Escherichia coli Proteins; Homocysteine; Methionine; Methylation; Mutation, Missense; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Temperature; Tetrahydrofolates; Vitamin B 12 | 2003 |
Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation.
Topics: Cell Transformation, Viral; Cells, Cultured; Folic Acid; Genotype; Homocysteine; Homozygote; Humans; Lymphocytes; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Riboflavin; Tetrahydrofolates | 2003 |
THE ROLE OF ADENOSYLMETHIONINE AND 5-METHYLTETRAHYDROFOLATE IN THE REGULATION OF THE METABOLISM OF SINGLE CARBON UNITS.
Topics: Anemia; Anemia, Macrocytic; Carbon; Folic Acid; Humans; Metabolism; Methionine; Nucleosides; Tetrahydrofolates; Vitamin B 12 | 1964 |
ENZYMATIC SYNTHESIS OF THE METHYL GROUP OF METHIONINE. IX. TRANSMETHYLATION FROM S-ADENOSYLMETHIONINE AND 5-METHYLTETRAHYDROFOLATE TO 2-MERCAPTOETHANOL AND HOMOCYSTEINE.
Topics: Alkylation; Biological Assay; Carbon Isotopes; Folic Acid; Homocysteine; Kinetics; Lactobacillus; Mercaptoethanol; Methionine; Nucleosides; Research; S-Adenosylmethionine; Spectrophotometry; Sulfhydryl Compounds; Tetrahydrofolates; Transferases | 1965 |
THE FORMATION OF CH4 FROM N-5-METHYLTETRAHYDROFOLATE MONOGLUTAMATE BY CELL-FREE EXTRACTS OF METHANOBACILLUS OMELIANSKII.
Topics: Adenosine Triphosphate; Autoradiography; Bacteria; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Glutamates; Homocysteine; Methane; Methionine; Research; Spectrophotometry; Tetrahydrofolates; Vitamin B 12 | 1965 |
All-trans-retinoic acid rapidly induces glycine N-methyltransferase in a dose-dependent manner and reduces circulating methionine and homocysteine levels in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Animals; Dose-Response Relationship, Drug; Glycine N-Methyltransferase; Homocysteine; Liver; Methionine; Methyltransferases; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Tetrahydrofolates; Time Factors; Tretinoin | 2003 |
Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Arabidopsis; Binding Sites; Cations; Crystallography, X-Ray; Cysteine; Escherichia coli; Folic Acid; Fourier Analysis; Histidine; Homocysteine; Methionine; Methyltransferases; Models, Molecular; Plasmids; Protein Conformation; Protein Structure, Tertiary; Sulfur; Tetrahydrofolates; Vitamin B 12; Zinc | 2004 |
A mathematical model of the folate cycle: new insights into folate homeostasis.
Topics: Allosteric Site; Animals; Dose-Response Relationship, Drug; Folic Acid; Homeostasis; Humans; Kinetics; Liver; Methionine; Methotrexate; Models, Biological; Models, Chemical; Models, Theoretical; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Up-Regulation; Vitamin B 12 Deficiency | 2004 |
Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle.
Topics: Adipose Tissue; Animals; Carbohydrates; Cystathionine beta-Synthase; Cysteine; Diet; Fibroblast Growth Factors; Gene Expression Profiling; Gene Expression Regulation; Gluconeogenesis; Inflammation; Ketones; Lipid Metabolism; Liver; Male; Mass Spectrometry; Methionine; Nutrigenomics; Quadriceps Muscle; Rats; Rats, Inbred F344; Tetrahydrofolates; Tissue Distribution | 2012 |
Involvement of 5-methyltetrahydrofolate in the amelioration of hyperhomocysteinemia caused by vitamin B(6) deficiency and L-methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Dietary Supplements; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Tetrahydrofolates; Vitamin B 6; Vitamin B 6 Deficiency | 2013 |
Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency.
Topics: Cell Line, Tumor; Cell Proliferation; Cellular Reprogramming; Cytosol; DNA Methylation; Folic Acid; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Meningioma; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Minor Histocompatibility Antigens; Neoplastic Stem Cells; Pluripotent Stem Cells; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2019 |
Four families of folate-independent methionine synthases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Archaeal Proteins; Bacterial Proteins; Biosynthetic Pathways; Folic Acid; Homocysteine; Iron-Sulfur Proteins; Methionine; Models, Chemical; Molecular Structure; Multigene Family; Oxygen; Tetrahydrofolates; Vitamin B 12 | 2021 |
Regulation of the one carbon folate cycle as a shared metabolic signature of longevity.
Topics: Animals; Caenorhabditis elegans; Carbon; Folic Acid; Insulin; Longevity; Metabolic Networks and Pathways; Metabolome; Methionine; Mice; Mitochondria; Mutation; Peptides; Signal Transduction; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase | 2021 |