Compounds > methapyrilene

methapyrilene and metyrapone

methapyrilene has been researched along with metyrapone in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Kammerer, RC; Lampe, MA1
Morgan, WA; Mullervy, J; Powell, CJ; Ratra, GS; Wright, MC1

Other Studies

4 other study(ies) available for methapyrilene and metyrapone

ArticleYear
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro.
    Carcinogenesis, 1987, Volume: 8, Issue:10

    Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole

1987
Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil.
    Toxicology, 1998, Sep-15, Volume: 130, Issue:2-3

    Topics: Adenosine Triphosphate; Animals; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Histamine H1 Antagonists; Hypophysectomy; Liver; Male; Methapyrilene; Metyrapone; Microsomes, Liver; Mitochondria, Liver; Oxidative Stress; Rats; Rats, Wistar; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Verapamil

1998