methapyrilene and alpha-aminopyridine

methapyrilene has been researched along with alpha-aminopyridine in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	54 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hill, SJ; Marrian, DH; Sanders, JK; Young, JM	1
English, PH; Temple, AR	1
Green, L; Mergens, WJ; Skipper, PL; Tannenbaum, SR; Vane, FM	1
Conner, CS; Hooper, RG; Rumack, BH	1
Hernandez, L; Lijinsky, W	1
Glauert, HP; Pitot, HC	1
Dent, JG; Graichen, ME; Leonard, TB; Neptun, DA; Popp, JA	1
Kovatch, RM; Lijinsky, W	1
Froines, JR; Kammerer, RC; Price, T	1
Katyal, SL; Perera, MI; Shinozuka, H	2
Cerniglia, CE; Hansen, EB; Korfmacher, WA; Lambert, KJ; Miller, DW	1
Allen, PT; Hernandez, L; Lijinsky, W; Poirier, LA	1
Bucana, CD; Iype, PT; Kelley, SP	1
Ashby, J; Callander, RD; Paton, D; Ratpan, F; Zeiger, E	1
Kammerer, RC; Lampe, MA	2
Kammerer, RC; Kloc, K; Lampe, MA; Schmitz, DA	2
Lijinsky, W; Yamashita, K	1
Kammerer, RC; Schmitz, DA	3
Meierhenry, EF; Mirsalis, JC; Spalding, JW; Steinmetz, KL; Tyson, CK	1
Casciano, DA; Shaddock, JG; Talaska, G	1
Castagnoli, N; Kratz, LE; Lijinsky, W; Rose, JE; Singer, SS	1
Mirsalis, JC	1
Clive, D; Hozier, JC; Sawyer, JR; Turner, NT; Woolley, JL	1
Eisenbrand, G; Habs, M; Shubik, P	1
Couri, D; Milks, MM; Wilt, SR	1
Althaus, FR; Lawrence, SD; Pitot, HC; Sattler, GL	1
Altmannsberger, M; Fischer, G; Katz, N; Schauer, A	1
Budroe, JD; Casciano, DA; Shaddock, JG	1
Lijinsky, W; Muschik, GM	1
Fischer, G; Fischer, W; Katz, NR	1
Mehta, RD; von Borstel, RC	1
Casciano, DA; Schol, HM	1
Lijinsky, W	1
Gregg, M; Reznik-Schüller, HM	1
Brennan, LM; Creasia, DA; Ohshima, M; Ward, JM	1
Furuya, K; Mori, H; Williams, GM	1
Fischer, W; Katz, NR; Wagle, SR	1
Furuya, K; Williams, GM	1
Chan, YL; Straus, W	1
Lijinsky, W; Reznik-Schüller, HM	3
Iype, PT; Kelley, SP; Lijinsky, W; Ray-Chaudhuri, R	1
Brennan, LM; Creasia, DA	1
Hallmark, MR; Shaikh, B	1
Castagnoli, N; Ho, B; Ziegler, R	1
Baselt, RC; Franch, S	1
Blackwell, BN; Lijinsky, W; Reuber, MD	1
Alferez, N; Azarnoff, DL; Calandre, EP; Hassanein, K	1

Trials

1 trial(s) available for methapyrilene and alpha-aminopyridine

Article	Year
Methapyrilene kinetics and dynamics. Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:4 Topics: Adult; Aminopyridines; Female; Humans; Kinetics; Male; Methapyrilene; Receptors, Histamine; Receptors, Histamine H1	1981

Other Studies

53 other study(ies) available for methapyrilene and alpha-aminopyridine

Article	Year
A convenient synthesis of [3H]mepyramine and certain related [3H]antihistamines. The Journal of pharmacy and pharmacology, 1978, Volume: 30, Issue:10 Topics: Aminopyridines; Chemical Phenomena; Chemistry; Histamine H1 Antagonists; Isotope Labeling; Methapyrilene; Methods; Pyrilamine; Tripelennamine; Tritium	1978
Treatment of methapyrilene toxicity with physostigmine. Veterinary and human toxicology, 1979, Volume: 21, Issue:2 Topics: Aminopyridines; Animals; Central Nervous System Diseases; Dogs; Male; Methapyrilene; Physostigmine	1979
In vitro nitrosation of methapyrilene. Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:7 Topics: Aminopyridines; Ascorbic Acid; Chemistry, Pharmaceutical; Drug Storage; Methapyrilene; Nitrites; Nitroso Compounds; Temperature	1979
Acute poisoning from over-the-counter sleep preparations. JACEP, 1979, Volume: 8, Issue:3 Topics: Adolescent; Adult; Aminopyridines; Arrhythmias, Cardiac; Child; Child, Preschool; Coma; Hallucinations; Humans; Hypertension; Infant; Methapyrilene; Nonprescription Drugs; Physostigmine; Retrospective Studies; Salicylamides; Scopolamine; Seizures	1979
Glutathione and lipid peroxide levels in rat liver following administration of methapyrilene and analogs. Chemico-biological interactions, 1989, Volume: 69, Issue:2-3 Topics: Aminopyridines; Animals; Glutathione; Histamine H1 Antagonists; Kinetics; Lipid Peroxidation; Lipid Peroxides; Liver; Male; Malondialdehyde; Methapyrilene; Pyridines; Rats; Rats, Inbred F344; Reference Values	1989
Effect of the antihistamine, methapyrilene, as an initiator of hepatocarcinogenesis in female rats. Cancer letters, 1989, Volume: 46, Issue:3 Topics: Adenosine Triphosphatases; Aminopyridines; Animals; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatectomy; Histocytochemistry; Liver Neoplasms, Experimental; Methapyrilene; Phenobarbital; Phenotype; Rats; Rats, Inbred F344	1989
Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1985, Volume: 5, Issue:1 Topics: Alanine Transaminase; Aminopyridines; Animals; Bile Acids and Salts; Bile Ducts; Chemical and Drug Induced Liver Injury; Epoxide Hydrolases; gamma-Glutamyltransferase; Liver Diseases; Liver Function Tests; Male; Methapyrilene; Microsomes, Liver; Mixed Function Oxygenases; Necrosis; Rats; Rats, Inbred F344	1985
Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats. Journal of cancer research and clinical oncology, 1986, Volume: 112, Issue:1 Topics: Aminopyridines; Animals; Female; Histamine H1 Antagonists; Liver Neoplasms; Male; Methapyrilene; Pyridines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Structure-Activity Relationship	1986
Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986, Volume: 24, Issue:9 Topics: Aminopyridines; Histamine H1 Antagonists; Methapyrilene; Mutagenicity Tests; Mutagens; Salmonella typhimurium	1986
Choline deficient diet enhances the initiating and promoting effects of methapyrilene hydrochloride in rat liver as assayed by the induction of gamma-glutamyltranspeptidase-positive hepatocyte foci. British journal of cancer, 1987, Volume: 56, Issue:6 Topics: Aminopyridines; Animals; Choline Deficiency; Enzyme Activation; gamma-Glutamyltransferase; Lipid Peroxides; Liver; Liver Neoplasms; Male; Membrane Lipids; Methapyrilene; Microsomes, Liver; Rats; Rats, Inbred Strains	1987
Fungal transformations of antihistamines: metabolism of methapyrilene, thenyldiamine and tripelennamine to N-oxide and N-demethylated derivatives. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:3 Topics: Aminopyridines; Biotransformation; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methapyrilene; Methylation; Mucorales; Oxides; Pyridines; Tripelennamine	1988
S-adenosylmethionine, S-adenosylhomocysteine and DNA methylation levels in the liver of rats fed methapyrilene and analogs. Carcinogenesis, 1989, Volume: 10, Issue:3 Topics: Aminopyridines; Animals; Carcinogens; Deoxycytidine; DNA; Homocysteine; Liver; Male; Methapyrilene; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine	1989
Carcinogenesis by nonmutagenic chemicals: early response of rat liver cells induced by methapyrilene. Cancer research, 1985, Volume: 45, Issue:5 Topics: Aminopyridines; Animals; Inclusion Bodies; Lipids; Liver; Liver Neoplasms, Experimental; Methapyrilene; Mitochondria, Liver; Rats; Rats, Inbred F344	1985
Weak and unexpected mutagenicity to Salmonella of the rat hepatocarcinogen methapyrilene. Environmental and molecular mutagenesis, 1988, Volume: 12, Issue:2 Topics: Aminopyridines; Animals; In Vitro Techniques; Methapyrilene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Rats; Salmonella typhimurium	1988
Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro. Carcinogenesis, 1987, Volume: 8, Issue:10 Topics: Acetylcysteine; Aminopyridines; Animals; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA; Methapyrilene; Methimazole; Metyrapone; Microsomes, Liver; NADP; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole	1987
The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:7 Topics: Aminopyridines; Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Liver Neoplasms; Male; Methapyrilene; Molecular Structure; Rats; Rats, Inbred Strains	1988
Lack of binding of methapyrilene and similar antihistamines to rat liver DNA examined by 32P postlabeling. Cancer research, 1988, Nov-15, Volume: 48, Issue:22 Topics: Aminopyridines; Animals; DNA; Liver; Male; Methapyrilene; Mutation; Phosphorus Radioisotopes; Quinolines; Rats; Rats, Inbred F344	1988
A comparative in vitro metabolic study of methaphenilene and pyribenzamine. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:9 Topics: Aminopyridines; Animals; Biotransformation; Gas Chromatography-Mass Spectrometry; Male; Methapyrilene; Microsomes, Liver; Oxides; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tripelennamine	1988
Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. Carcinogenesis, 1988, Volume: 9, Issue:6 Topics: 2-Acetylaminofluorene; Adult; Alanine Transaminase; Aminopyridines; Animals; Aspartate Aminotransferases; Bilirubin; Carcinogens; DNA Replication; Female; Humans; L-Iditol 2-Dehydrogenase; Liver; Male; Methapyrilene; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344	1988
The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats. Mutation research, 1988, Volume: 208, Issue:3-4 Topics: Aminopyridines; Animals; Carcinogens; DNA; DNA Damage; DNA Repair; DNA Replication; Interphase; Liver; Liver Regeneration; Methapyrilene; Rats; Rats, Inbred F344	1988
A comparison of in vivo and in vitro metabolites of the H1-antagonist N,N-dimethyl-N'-2-pyridyl-N'-(2-thienylmethyl)-1,2-ethanediamine (methapyrilene) in the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:11 Topics: Aminopyridines; Animals; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Glucuronidase; In Vitro Techniques; Male; Methapyrilene; Microsomes, Liver; Rats; Rats, Inbred F344; Rats, Inbred Strains	1987
Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene. Mutation research, 1987, Volume: 185, Issue:3 Topics: Aminopyridines; Animals; Biotransformation; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA Damage; DNA Repair; Female; Liver; Male; Methapyrilene; Mice; Mutation; Rats; Salmonella typhimurium	1987
Oxidation of the pyridine ring: a major pathway of metabolism for the rat hepatocarcinogen, methapyrilene. Proceedings of the Western Pharmacology Society, 1987, Volume: 30 Topics: Aminopyridines; Animals; Cricetinae; Guinea Pigs; Liver Neoplasms, Experimental; Male; Methapyrilene; Methylation; Mice; Oxidation-Reduction; Pyridines; Rats; Rats, Inbred Strains; Species Specificity	1987
Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK +/- mouse lymphoma assay. Mutation research, 1987, Volume: 189, Issue:3 Topics: Aminopyridines; Animals; Biotransformation; Carcinogens; Chromosome Aberrations; Leukemia L5178; Methapyrilene; Mice; Microsomes, Liver; Mutagenicity Tests; Neoplasm Proteins; Preservation, Biological; Pyrilamine; Rats; Thymidine Kinase; Tumor Cells, Cultured; Tumor Stem Cell Assay	1987
Species differences in the in vitro metabolism of methapyrilene. Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:9 Topics: Aminopyridines; Animals; Biotransformation; Chromatography, Gas; Guinea Pigs; In Vitro Techniques; Male; Mass Spectrometry; Methapyrilene; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Species Specificity	1987
Metabolism of methapyrilene by rat-liver homogenate. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:7 Topics: Aminopyridines; Animals; Gas Chromatography-Mass Spectrometry; Liver; Male; Methapyrilene; Rats; Rats, Inbred Strains; Thiophenes	1986
The effect of chronic methapyrilene treatment on methapyrilene metabolism in vitro. Carcinogenesis, 1987, Volume: 8, Issue:2 Topics: Aminopyridines; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Administration Schedule; Liver; Male; Methapyrilene; Microsomes, Liver; Rats	1987
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats. Journal of cancer research and clinical oncology, 1986, Volume: 111, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Aminopyridines; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methapyrilene; Neoplasms, Experimental; Pyridines; Pyrilamine; Rats; Structure-Activity Relationship; Tripelennamine	1986
Methapyrilene induces membrane lipid peroxidation of rat liver cells. Carcinogenesis, 1985, Volume: 6, Issue:6 Topics: Aminopyridines; Animals; Cell Membrane; Lipid Peroxides; Liver; Male; Methapyrilene; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Inbred Strains	1985
Methapyrilene effects on initiation and promotion of gamma-glutamyl-transpeptidase positive foci in rat liver. Research communications in chemical pathology and pharmacology, 1982, Volume: 35, Issue:1 Topics: Aminopyridines; Animals; gamma-Glutamyltransferase; Hepatectomy; Liver; Male; Methapyrilene; Rats; Rats, Inbred Strains	1982
DNA damage induced by the antihistaminic drug methapyrilene hydrochloride. Mutation research, 1982, Volume: 103, Issue:3-6 Topics: Aminopyridines; Animals; Carcinogens; Cells, Cultured; DNA; DNA Repair; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Liver; Male; Methapyrilene; Rats; Stimulation, Chemical	1982
Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride. Journal of cancer research and clinical oncology, 1983, Volume: 106, Issue:1 Topics: Adenosine Triphosphatases; Administration, Oral; Aminopyridines; Animals; Female; gamma-Glutamyltransferase; Liver Neoplasms; Methapyrilene; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains	1983
A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay. Mutation research, 1984, Volume: 135, Issue:2 Topics: Aminopyridines; Animals; Cell Survival; Cells, Cultured; DNA Repair; Histamine H1 Antagonists; Kinetics; Liver; Male; Methapyrilene; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Inbred F344	1984
Distribution of the liver carcinogen methapyrilene in Fischer rats and its interaction with macromolecules. Journal of cancer research and clinical oncology, 1982, Volume: 103, Issue:1 Topics: Aminopyridines; Animals; Carcinogens; DNA; Drug Interactions; Liver; Male; Methapyrilene; Protein Binding; Proteins; Rats; RNA; Tissue Distribution; Tritium	1982
Inversion of the metabolic zonation of rat liver parenchyma by methapyrilene treatment. Pharmacology, biochemistry, and behavior, 1983, Volume: 18 Suppl 1 Topics: Aminopyridines; Animals; Female; Glucokinase; Gluconeogenesis; Glucose-6-Phosphatase; Glycolysis; Hexokinase; Liver; Methapyrilene; Rats; Rats, Inbred Strains	1983
Genetic activity in yeast assays of reputed nonmutagenic, carcinogenic N-nitroso compounds and methapyrilene hydrochloride. IARC scientific publications, 1984, Issue:57 Topics: Aminopyridines; Carcinogens; Diethylnitrosamine; Genes, Fungal; Methapyrilene; Mutagenicity Tests; Mutagens; Nitrosamines; Saccharomyces cerevisiae	1984
Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay. Cancer letters, 1984, Volume: 21, Issue:3 Topics: Aminopyridines; Animals; Cricetinae; Cricetulus; Female; Hypoxanthine Phosphoribosyltransferase; Liver Neoplasms; Male; Methapyrilene; Mutagenicity Tests; Mutagens; Ovary; Rats; Rats, Inbred Strains	1984
Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1984, Volume: 22, Issue:1 Topics: Aminopyridines; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Male; Methapyrilene; Pyrilamine; Rats; Rats, Inbred F344; Structure-Activity Relationship; Time Factors	1984
Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats. Journal of the National Cancer Institute, 1983, Volume: 71, Issue:5 Topics: Aminopyridines; Animals; Eosinophilia; Liver; Liver Neoplasms, Experimental; Male; Methapyrilene; Mitochondria; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors	1983
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats. Journal of the National Cancer Institute, 1984, Volume: 72, Issue:3 Topics: Aminopyridines; Animals; Body Weight; Carcinogens; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methapyrilene; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors	1984
An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide. Toxicology and applied pharmacology, 1983, Volume: 70, Issue:1 Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Liver Neoplasms, Experimental; Male; Methapyrilene; Phenobarbital; Rats; Rats, Inbred F344	1983
Altered distribution of hexokinase and glucokinase between parenchymal and nonparenchymal cells of rat liver after methapyrilene intoxication. Biochemical and biophysical research communications, 1983, Sep-30, Volume: 115, Issue:3 Topics: Aminopyridines; Animals; Female; Glucokinase; Hexokinase; Kinetics; Liver; Methapyrilene; Rats; Rats, Inbred Strains	1983
Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide. Toxicology and applied pharmacology, 1984, Jun-15, Volume: 74, Issue:1 Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Diethylnitrosamine; DNA; Drug Synergism; Liver Neoplasms; Male; Methapyrilene; Rats; Rats, Inbred F344	1984
Influence of the tubular flow rates on the endocytic uptake and the excretion of horseradish peroxidase by rat kidney. Biochemical and biophysical research communications, 1980, Mar-13, Volume: 93, Issue:1 Topics: Aminopyridines; Animals; Diuresis; Endocytosis; Glomerular Filtration Rate; Hematocrit; Horseradish Peroxidase; Kidney Cortex; Kidney Tubules; Male; Mannitol; Methapyrilene; Methysergide; Osmolar Concentration; Peroxidases; Rats; Sodium Chloride	1980
Methaphenilene, an analogue of the antihistaminic methapyrilene, is a "peroxisome proliferator". Archives of toxicology, 1983, Volume: 52, Issue:2 Topics: Aminopyridines; Animals; Liver; Methapyrilene; Microbodies; Organoids; Rats	1983
Ultrastructural changes in the liver of animals treated with methapyrilene and some analogs. Ecotoxicology and environmental safety, 1982, Volume: 6, Issue:4 Topics: Aminopyridines; Animals; Cricetinae; Female; Guinea Pigs; Liver; Male; Mesocricetus; Methapyrilene; Mitochondria, Liver; Rats; Rats, Inbred F344; Species Specificity	1982
Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo. Cancer research, 1982, Volume: 42, Issue:11 Topics: Aminopyridines; Animals; Bone Marrow; Cell Line; Clone Cells; Cricetinae; Cricetulus; Crossing Over, Genetic; Female; Liver; Lung; Methapyrilene; Ovary; Rats; Rats, Inbred Strains; Sister Chromatid Exchange	1982
The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice. Toxicology and applied pharmacology, 1982, Volume: 66, Issue:2 Topics: Aminopyridines; Animals; Enzyme Induction; Female; Liver; Liver Neoplasms; Male; Methapyrilene; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pentobarbital; Rats; Rats, Inbred F344; Sleep	1982
High performance liquid chromatographic determination of methapyrilene hydrochloride in feed and sleep aid tablets. Journal - Association of Official Analytical Chemists, 1981, Volume: 64, Issue:4 Topics: Aminopyridines; Animal Feed; Chromatography, High Pressure Liquid; Hypnotics and Sedatives; Methapyrilene; Tablets	1981
Morphology of early changes in liver carcinogenesis induced by methapyrilene. Archives of toxicology, 1981, Volume: 49, Issue:1 Topics: Aminopyridines; Animals; Female; Liver; Liver Neoplasms; Methapyrilene; Microscopy, Electron; Rats; Rats, Inbred F344; Subcellular Fractions	1981
Trapping of metabolically generated electrophilic species with cyanide ion: metabolism of methapyrilene. Journal of medicinal chemistry, 1981, Volume: 24, Issue:10 Topics: Aminopyridines; Animals; Biotransformation; Chromatography, Gas; Cyanides; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Methapyrilene; Microsomes, Liver; NADP; Rabbits	1981
Plasma and urine concentrations of methapyrilene by nitrogen-phosphorus gas-liquid chromatography. Journal of chromatography, 1980, Aug-08, Volume: 183, Issue:2 Topics: Aminopyridines; Chromatography, Gas; Humans; Methapyrilene	1980
Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride. Science (New York, N.Y.), 1980, Aug-15, Volume: 209, Issue:4458 Topics: Aminopyridines; Animals; Carcinogens; Drug Interactions; Female; Liver Neoplasms, Experimental; Male; Methapyrilene; Neoplasm Metastasis; Nitrites; Rats	1980