Compounds > methanol

methanol and pf-543

methanol has been researched along with pf-543 in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's15 (53.57)24.3611
2020's13 (46.43)2.80

Authors

AuthorsStudies
Broadus, R; Chrencik, J; Cronin, CN; Cukyne, K; Fujiwara, H; Hall, T; Highkin, MK; Iyanar, K; Jerome, G; Kasten, T; Kraus, M; McReynolds, MD; Nagiec, MM; Nemirovskiy, O; Ogawa, S; Peterkin, V; Rains, JW; Saabye, M; Schnute, ME; Scholten, JA; Wendling, J; Wittwer, AJ; Yates, M; Zawadzke, LE1
Lynch, KR1
Abdulmalik, OY; Ahmed, MH; Alexander, DC; Berka, V; Bogdanov, M; Dowhan, W; Idowu, M; Jin, J; Juneja, HS; Kato, GJ; Kellems, RE; Li, C; Lin, H; Milburn, MV; Ning, C; Safo, M; Song, A; Sun, K; Tsai, AL; Wang, W; Xia, Y; Zhang, J; Zhang, P; Zhang, Q; Zhang, W; Zhang, Y1
Bujons, J; Casas, J; Casasampere, M; Cingolani, F; Fabrias, G; Sanllehí, P1
Fang, ZY; Gao, D; Ju, T1
Dai, D; Lv, M; Zhang, D; Zhang, L; Zhang, W1
Al Washih, M; Futerman, AH; Kennedy, S; MacRitchie, N; Pyne, NJ; Pyne, S; Volpert, G; Watson, DG1
Cheng, Y; Dai, D; Li, S; Lv, M; Su, D; Zhang, W1
Du, C; Du, Y; Duan, H; Duan, J; Ren, Y; Shi, Y; Xiao, X; Yao, F; Zhao, H1
Chang, W; Hu, B; Liang, Y; Wang, S; Zhang, Y1
Agah, S; Barkey-Bircann, P; Eletu, OT; Gesualdi, J; Huang, T; Kharel, Y; Lynch, KR; Mendelson, AJ; Santos, WL; Smith, JS1
Baek, DJ; Han, DS; Hong, SW; Hwang, GT; Jin, YJ; Jo, G; Kim, S; Lee, JY; Lee, T; Oh, YS; Park, EY; Shrestha, J1
Baek, DJ; Kim, S; Kim, SW; Lee, JY; Lee, T; Oh, YS; Park, EY; Shin, SM1
Liu, B; Shi, Y; Sun, M; Zhou, Y1
Baek, DJ; Hong, SW; Hwang, GT; Kim, S; Kim, SW; Kwon, Y; Lee, T; Oh, YS; Park, EY; Seop Moon, H; Shrestha, J1
He, L; Li, L; Liu, L; Sha, Y; Sheng, L; Shi, M; Wang, H; Wen, S; Wu, F; You, Q; Zhang, J; Zhou, H1
Crespo, E; Guzik, TJ; Józefczuk, E; Nosalski, R; Saju, B; Siedlinski, M; Szczepaniak, P1
Cheresh, P; Ebenezer, DL; Fu, P; Ha, AW; Harijith, A; Huang, LS; Kamp, DW; Natarajan, V; Punathil-Kannan, PK; Putherickal, V; Ramchandran, R; Sudhadevi, T; Zhou, G1
Baek, DJ; Ki, SH; Kim, S; Kim, SB; Kwon, Y; Lee, JY; Lee, T; Moon, HS; Oh, YS; Park, EY; Park, JE1
Ackerman, SJ; Berdyshev, EV; Ebenezer, DL; Fu, P; Ha, AW; Harijith, A; Natarajan, V; Sudhadevi, T1
Budinger, GRS; Cheresh, P; Chi, M; Gottardi, C; Harijith, A; Huang, LS; Joshi, N; Kamp, DW; Kim, SJ; Lam, AP; Lu, Z; Misharin, AV; Natarajan, V; Watanabe, S; Williams, KJN; Yeldandi, A1
Jin, L; Li, S; Li, T; Mu, J; Zhou, J; Zhu, C1
Jia, X; Lachance, BB; Shen, G; Tang, C; Wang, C; Xu, T; Zhong, X1
Chen, L; Li, L; Lv, T; Song, Y1
Baek, DJ; Gulyamov, S; Jung, SH; Kim, HJ; Lee, YM; Shamshiddinova, M1
Birch, CA; Chen, B; Cisneros-Aguirre, M; Coronel, LJ; Gomez Menzies, PK; Grimsey, NJ; Lawson, MA; Lin, H; Molinar-Inglis, O; Nicholas, D; Orduña-Castillo, L; Patel, HH; Patwardhan, A; Trejo, J1
Basa, P; Ha, AW; Harijith, A; Natarajan, V; Sudhadevi, T; Thomas, JM1
Baek, DJ; Cho, SW; Kim, KJ; Kim, SB; Oh, YS; Park, EY; Park, SK1

Reviews

1 review(s) available for methanol and pf-543

ArticleYear
The Role of Sphingolipid Signaling in Oxidative Lung Injury and Pathogenesis of Bronchopulmonary Dysplasia.
    International journal of molecular sciences, 2022, Jan-23, Volume: 23, Issue:3

    Topics: Airway Remodeling; Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Ceramides; Disease Models, Animal; Humans; Hyperoxia; Infant; Infant, Newborn; Lung; Lung Injury; Lysophospholipids; Methanol; Mice; Oxidative Stress; Pulmonary Alveoli; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Sphingolipids; Sphingosine; Sulfones

2022

Other Studies

27 other study(ies) available for methanol and pf-543

ArticleYear
Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.
    The Biochemical journal, 2012, May-15, Volume: 444, Issue:1

    Topics: Cell Line, Tumor; Cell Membrane Permeability; Humans; Lysophospholipids; Methanol; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Sphingosine; Substrate Specificity; Sulfones

2012
Building a better sphingosine kinase-1 inhibitor.
    The Biochemical journal, 2012, May-15, Volume: 444, Issue:1

    Topics: Humans; Lysophospholipids; Methanol; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Sphingosine; Sulfones

2012
Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:6

    Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Erythrocytes, Abnormal; Gene Knockdown Techniques; Hemolysis; Humans; Lysophospholipids; Metabolomics; Methanol; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Signal Transduction; Sphingosine; Sulfones

2014
Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.
    Journal of lipid research, 2014, Volume: 55, Issue:8

    Topics: Autophagy; Enzyme Inhibitors; G1 Phase; HeLa Cells; Humans; Methanol; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Resting Phase, Cell Cycle; Sulfones

2014
Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543.
    Biochemical and biophysical research communications, 2016, Feb-12, Volume: 470, Issue:3

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Methanol; Mice; Mice, SCID; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Sulfones; Survival Rate; Treatment Outcome

2016
Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2016, Volume: 65, Issue:7

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cells, Cultured; Glucose; Hypoxia, Brain; Infarction, Middle Cerebral Artery; Interleukin-17; Lysophospholipids; Male; Methanol; Microglia; Neurons; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Small Interfering; Sphingosine; Sulfones

2016
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
    Cellular signalling, 2016, Volume: 28, Issue:8

    Topics: Animals; Biomarkers; Body Weight; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Female; Heart Ventricles; HEK293 Cells; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Methanol; Mice, Inbred C57BL; Models, Biological; Myocytes, Smooth Muscle; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Pressure; Pulmonary Artery; Pyrrolidines; Signal Transduction; Sulfones; Ventricular Remodeling

2016
Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusion.
    Journal of neuroimmunology, 2017, 04-15, Volume: 305

    Topics: Animals; Animals, Newborn; Cells, Cultured; Disease Models, Animal; Encephalitis; Glucose; Hypoxia; Infarction, Middle Cerebral Artery; Interleukin-17; Male; Methanol; Microglia; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Rats; Rats, Sprague-Dawley; Reperfusion; Signal Transduction; Sulfones; TNF Receptor-Associated Factor 2

2017
Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy.
    The international journal of biochemistry & cell biology, 2017, Volume: 90

    Topics: Animals; Autophagy; Cell Line; Enzyme Activation; Epithelial Cells; Fibrosis; Humans; Kidney Tubules; Male; Methanol; Mice; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Sulfones; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction

2017
Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Apr-01, Volume: 24

    Topics: Animals; Cell Line, Tumor; Doxorubicin; Drug Synergism; Female; Fluorouracil; Heterografts; Humans; Lysophospholipids; MCF-7 Cells; Methanol; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Receptor, ErbB-2; Receptors, Lysosphingolipid; Receptors, Notch; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Sulfones; Triple Negative Breast Neoplasms; Up-Regulation

2018
Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.
    PloS one, 2018, Volume: 13, Issue:4

    Topics: Animals; Drug Evaluation, Preclinical; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Methanol; Mice; Mutation; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Saccharomyces cerevisiae; Sphingolipids; Sulfones

2018
Synthesis of dansyl labeled sphingosine kinase 1 inhibitor.
    Chemistry and physics of lipids, 2018, Volume: 215

    Topics: Binding Sites; Fluorescent Dyes; Methanol; Molecular Docking Simulation; Molecular Structure; Phosphatidylcholines; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Kinase Inhibitors; Pyrrolidines; Spectrometry, Fluorescence; Structure-Activity Relationship; Sulfones; Xylenes

2018
Synthesis and Biological Evaluation of PF-543 Derivative Containing Aliphatic Side Chain.
    Chemical & pharmaceutical bulletin, 2019, Volume: 67, Issue:6

    Topics: Antineoplastic Agents; Binding Sites; Catalytic Domain; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Methanol; Molecular Docking Simulation; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Structure-Activity Relationship; Sulfones

2019
Effect of the Sphingosine Kinase 1 Selective Inhibitor, PF543 on Dextran Sodium Sulfate-Induced Colitis in Mice.
    DNA and cell biology, 2019, Volume: 38, Issue:11

    Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Lysophospholipids; Male; Methanol; Mice; Mice, Inbred C57BL; Organ Size; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Sphingosine; Spleen; Substrate Specificity; Sulfones

2019
Synthesis and Biological Evaluation of BODIPY-PF-543.
    Molecules (Basel, Switzerland), 2019, Dec-02, Volume: 24, Issue:23

    Topics: Boron Compounds; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Methanol; Molecular Structure; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Spectrum Analysis; Structure-Activity Relationship; Sulfones

2019
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition.
    Cell death and differentiation, 2020, Volume: 27, Issue:6

    Topics: Acetaminophen; Animals; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Fingolimod Hydrochloride; Methanol; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Transmembrane Permeability-Driven Necrosis; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Sphingosine-1-Phosphate Receptors; Sulfones

2020
Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1.
    Hypertension (Dallas, Tex. : 1979), 2020, Volume: 75, Issue:2

    Topics: Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Injections, Intraperitoneal; Lysophospholipids; Male; Methanol; Mice; Mice, Inbred C57BL; Myocardium; Pyrrolidines; RNA; Signal Transduction; Sphingosine; Sulfones; Ventricular Remodeling

2020
Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
    International journal of molecular sciences, 2020, Mar-17, Volume: 21, Issue:6

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Alveolar Epithelial Cells; Animals; Bleomycin; Cell Cycle Proteins; Fibroblasts; Fibronectins; Gene Deletion; Gene Expression; Hippo Signaling Pathway; Humans; Idiopathic Pulmonary Fibrosis; Immunohistochemistry; Lysophospholipids; Methanol; Mice; Mitochondria; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Sphingosine; Sulfones; Transcription Factors; Transforming Growth Factor beta1; YAP-Signaling Proteins

2020
Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity.
    Molecules (Basel, Switzerland), 2020, May-27, Volume: 25, Issue:11

    Topics: Animals; Boron Compounds; Dogs; Humans; Methanol; Mice; Microsomes, Liver; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Rats; Structure-Activity Relationship; Sulfones

2020
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia.
    American journal of physiology. Lung cellular and molecular physiology, 2020, 09-01, Volume: 319, Issue:3

    Topics: Airway Remodeling; Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Disease Models, Animal; Hyperoxia; Lung; Methanol; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Sulfones

2020
The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
    International journal of molecular sciences, 2020, Aug-05, Volume: 21, Issue:16

    Topics: Adaptor Proteins, Signal Transducing; Alveolar Epithelial Cells; Animals; Asbestos; Bleomycin; DNA Damage; DNA, Mitochondrial; Humans; Idiopathic Pulmonary Fibrosis; Lung; Methanol; Mice; Mitochondria; Monocytes; Pulmonary Fibrosis; Pyrrolidines; Signal Transduction; Sulfones

2020
Urocortin participates in LPS-induced apoptosis of THP-1 macrophages via S1P-cPLA2 signaling pathway.
    European journal of pharmacology, 2020, Nov-15, Volume: 887

    Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Atherosclerosis; Gene Expression Regulation; Humans; Lipopolysaccharides; Methanol; Mitogen-Activated Protein Kinases; NF-kappa B; Phospholipases A2, Cytosolic; Proprotein Convertases; Pyrrolidines; Serine Endopeptidases; Signal Transduction; Sulfones; THP-1 Cells; Urocortins

2020
Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury.
    Journal of neuroinflammation, 2021, Feb-18, Volume: 18, Issue:1

    Topics: Animals; Female; Inflammation Mediators; Methanol; Mice; Neurons; PC12 Cells; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Sulfones; Thoracic Vertebrae

2021
Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice.
    Inflammation, 2021, Volume: 44, Issue:6

    Topics: Alcoholic Intoxication; Animals; Apoptosis; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Inflammation Mediators; Lung; Lung Injury; Lysophospholipids; Male; Methanol; Mice, Inbred C57BL; Neutrophil Infiltration; Oxidative Stress; Phosphotransferases (Alcohol Group Acceptor); Pneumonia; Pulmonary Edema; Pyrrolidines; Sepsis; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Sulfones

2021
A Dansyl-Modified Sphingosine Kinase Inhibitor DPF-543 Enhanced De Novo Ceramide Generation.
    International journal of molecular sciences, 2021, Aug-25, Volume: 22, Issue:17

    Topics: Animals; Cell Line; Cell Survival; Ceramides; Dansyl Compounds; Enzyme Inhibitors; Humans; Methanol; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Sphingosine; Substrate Specificity; Sulfones; Swine

2021
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 12-07, Volume: 118, Issue:49

    Topics: Anilides; Apoptosis; beta-Arrestin 2; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Humans; Lactones; Methanol; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Platelet Aggregation Inhibitors; Protein C; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Receptor, PAR-1; Sphingosine-1-Phosphate Receptors; Sulfones

2021
Synthesis of PP2A-Activating PF-543 Derivatives and Investigation of Their Inhibitory Effects on Pancreatic Cancer Cells.
    Molecules (Basel, Switzerland), 2022, May-23, Volume: 27, Issue:10

    Topics: Fingolimod Hydrochloride; Humans; Methanol; Molecular Docking Simulation; Pancreatic Neoplasms; Protein Phosphatase 2; Pyrrolidines; Sulfones

2022