methamphetamine and selegiline

methamphetamine has been researched along with selegiline in 84 studies

Research

Studies (84)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (11.90)	18.7374
1990's	35 (41.67)	18.2507
2000's	30 (35.71)	29.6817
2010's	8 (9.52)	24.3611
2020's	1 (1.19)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Blau, K; Elsworth, JD; Lees, AJ; Reynolds, GP; Sandler, M; Stern, GM	1
Johnson, SK; Medina, D; Wagner, GC	1
Kraemer, T; Maurer, HH	1
Baker, GB; Caffaro, LE; Coutts, RT; Greenshaw, AJ; Paetsch, PR; Rauw, GA	1
Elebring, T; Engberg, G; Nissbrandt, H	1
Wagner, GC; Walsh, SL	1
Salonen, JS	1
Axelsson, S; Inoue, O; Långström, B; Lundqvist, H; Oreland, L	1
Antonin, KH; Bieck, PR; Hoffmann, E; Jedrychowski, M; Nilsson, E; Schick, C; Schulz, R	1
Kuroiwa, Y; Yamada, Y; Yamamoto, T; Yoshida, T	1
Egashira, T; Yamamoto, T; Yamanaka, Y	1
Robinson, JB	1
Hardie, RJ; Lees, AJ; Sandler, M; Stern, GM	1
Asano, M; Hattori, H; Katsumata, Y; Oya, M; Suzuki, O	1
Katsumata, Y; Oya, M; Suzuki, O	1
Calne, DB; Chuang, LW; Eisler, T; Karoum, F; Klein, DF; Liebowitz, MR; Quitkin, FM; Wyatt, RJ	1
Elsworth, JD; Lees, AJ; Sandler, M; Stern, GM; Ward, C	1
Kikura, R; Nakahara, Y	1
Chafetz, L; Desai, MP; Sukonik, L	1
Knoll, J; Miklya, I	1
La Croix, R; Pianezzola, E; Strolin Benedetti, M	1
Mahmood, I; Mason, WD; Neau, SH	1
Bhattacharya, N; Holland, D; Murray, B; Oh, C; Tatton, WG	1
Dadgar, D; Mamer, OA; Reimer, ML; Siddiqui, AW; Zavitsanos, AP	1
Greedan, A; Needleman, SB; Romberg, RW; Snyder, JJ	1
Gaál, J; Lengyel, J; Magyar, K; Szatmári, I; Szebeni, G; Székács, G	1
Bosc, M; Deffond, D; Dordain, G; Dostert, P; Fiorentini, F; La Croix, R; Persiani, S; Strolin Benedetti, M; Vernay, D	1
Ingelse, BA; Lemr, K; Sevcík, J; Stránský, Z	1
Barrett, JS; De Witt, KE; Ireland, J; Morales, RJ; Rajewski, G; Rohatagi, S; Szego, P	1
Cooper, T; Gaál, J; Hashim, A; Lajtha, A; Sershen, H	1
Duursema, L; Groenewoud, G; Hundt, HK; Joubert, A; Middle, MV; Muir, AR; Müller, FO; Schall, R; Swart, KJ	1
Goldberg, JP; Goldberg, SR; Yasar, S	1
Kikuta, C; Ludwig, G; Mascher, HJ; Millendorfer, A; Schiel, H	1
Behar, D; Schaller, JL	1
Barrett, JS; DeWitt, KE; Morales, RJ; Rohatagi, S	1
Barrett, JS; DeWitt, KE; Lessard, D; Morales, RJ; Rohatagi, S	1
Commissiong, JW; Finberg, JP; Johnston, JM; Takeshima, T	1
Báthori, M; Fürst, S; Hollósi, I; Kalász, H; Szebeni, G; Tarjányi, Z	1
Anttila, M; Bertilsson, L; Dahl, ML; Karnani, H; Nyman, L; Pelkonen, O; Scheinin, H; Taavitsainen, P	1
Cho, AK; Kuczenski, R; Melega, WP; Schmitz, D; Segal, DS	1
Chaturvedi, AK; Kupiec, TC	1
Bartók, T; Fürst, S; Haberle, D; Hennings, EC; Kalász, H; Kiss, JP; Magyar, K; Szöko, E	1
Fukushima, S; Hasegawa, M; Kimura, K; Maseda, C; Matsubara, K; Uezono, T	1
Caslavska, J; Ramseier, A; Thormann, W	1
Kalász, H; Magyar, K; Szökö, E	1
Musshoff, F	1
Bach, MV; Baker, GB; Coutts, RT	1
Anttila, M; Karnani, H; Nyman, L; Pelkonen, O; Salonen, JS; Taavitsainen, P	1
Bocsi, J; Bökönyi, G; Kéri, G; Magyar, K; Szende, B; Timár, F	1
Azevedo, R; Ghosh, S; Grasing, K; Karuppan, S	1
Anttila, M; Backman, JT; Kivistö, KT; Neuvonen, PJ; Nyman, L; Taavitsainen, P; Wang, JS	1
Ahlner, J; Andersson, MC; Kronstrand, R; Larson, G	1
Cody, JT	1
Anttila, M; Laine, K; Nyman, L; Palovaara, S	1
Kamata, T; Katagi, M; Miki, A; Nakajima, K; Nishikawa, M; Nishioka, H; Tatsuno, M; Tsuchihashi, H; Tsutsumi, H	1
Foltz, RL; Moody, DE; Slawson, MH; Taccogno, JL	1
Ahlner, J; Dizdar, N; Kronstrand, R; Larson, G	1
Brewer, F; Clarke, A; Corn, TH; Hartig, F; Johnson, ES; Mallard, N; Taylor, S	1
Gee, WL; Gilman, JP; Graczyk, Z; Schindler, CW; Wang, G	1
Kim, M; Myung, SW; Yoon, SH	1
Abassi, ZA; Binah, O; Youdim, MB	1
Borbás, T; Dalmadi, B; Magyar, K; Szöko, E; Tábi, T; Tihanyi, K	1
Kitanaka, J; Kitanaka, N; Takemura, M	1
Bergman, J; Gaal, J; Justinova, Z; Yasar, S	1
Kitanaka, J; Kitanaka, N; Morita, Y; Takemura, M; Tatsuta, T	1
Anderson, A; Bloch, DA; Chiang, N; De La Garza, R; Elkashef, A; Fong, T; Holmes, TH; Newton, TF	1
Ikeda, N; Inoue, N; Itoh, S; Kudo, K; Nishida, K	1
Grasing, K; He, S	1
Alok, R; Benetton, SA; Fang, C; Lin, CC; Yang, YO; Year, M; Yeh, LT	1
Chen, Q; Davidson, C; Ellinwood, EH; Lazarus, C; Lee, TH; Xiong, X; Zhang, X	1
Blaugrund, E; Cohen, S; Eliash, S; Fine, T; Litinetsky, L; Speiser, Z	1
Lengyel, J; Magyar, K; Szatmáry, I; Szebeni, G	1
Aoki, Y; Endo, S; Fujino, Y; Fujita, Y; Inoue, Y; Niitsu, H; Onodera, M; Takahashi, K; Takei, M	1
Everhart, T; Harris, DS; Jacob, P; Jones, RT; Lin, E; Mendelson, JE	1
Dimpfel, W; Hoffmann, JA; Müller, T; Oehlwein, C	1
Kakish, J; Lee, JS; Tavassoly, O	1
Bu, J; Qiao, Z; Shen, M; Wu, HJ; Xiang, P; Zhuo, XY	1
Chen, L; Duan, G; Shen, B; Shi, Y; Wang, S; Xiang, P; Yan, H; Yu, Y	1
Choi, H; Kang, S; Kim, J; Park, Y; Shin, I; Yang, W	1

Reviews

4 review(s) available for methamphetamine and selegiline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Are metabolites of l-deprenyl (selegiline) useful or harmful? Indications from preclinical research. Journal of neural transmission. Supplementum, 1996, Volume: 48 Topics: Amphetamine; Animals; Biotransformation; Cocaine; Cognition; Conditioning, Operant; Drug Evaluation, Preclinical; Electroencephalography; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Nootropic Agents; Phenethylamines; Rats; Rats, Inbred F344; Reinforcement, Psychology; Saimiri; Selegiline; Self Administration	1996
Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine. Drug metabolism reviews, 2000, Volume: 32, Issue:1 Topics: Amphetamines; Animals; Benzphetamine; Furans; Hair; Humans; Methamphetamine; Pyrazoles; Pyrazolones; Selegiline; Sydnones; Theophylline	2000
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results. Journal of occupational and environmental medicine, 2002, Volume: 44, Issue:5 Topics: Amphetamine; Amphetamines; Benzphetamine; Caffeine; Furans; Humans; Methamphetamine; Molecular Structure; Prenylamine; Prodrugs; Pyrazoles; Pyrazolones; Selegiline; Substance Abuse Detection; Sydnones; Theophylline	2002

Trials

12 trial(s) available for methamphetamine and selegiline

Article	Year
Deprenyl is metabolized to methamphetamine and amphetamine in man. British journal of clinical pharmacology, 1978, Volume: 6, Issue:6 Topics: Amphetamine; Biotransformation; Humans; Male; Methamphetamine; Phenethylamines; Selegiline	1978
Lack of pharmacokinetic interaction between the selective dopamine agonist cabergoline and the MAO-B inhibitor selegiline. Journal of neural transmission. Supplementum, 1995, Volume: 45 Topics: Aged; Amphetamine; Amphetamines; Antiparkinson Agents; Cabergoline; Dopamine Agonists; Drug Interactions; Ergolines; Female; Humans; Male; Methamphetamine; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Selegiline	1995
Bioavailability of two selegiline hydrochloride tablet products. Arzneimittel-Forschung, 1996, Volume: 46, Issue:11 Topics: Adolescent; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Dopamine Uptake Inhibitors; Double-Blind Method; Female; Half-Life; Humans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Tablets	1996
Integrated pharmacokinetic and metabolic modeling of selegiline and metabolites after transdermal administration. Biopharmaceutics & drug disposition, 1997, Volume: 18, Issue:7 Topics: Administration, Cutaneous; Amphetamine; Amphetamines; Antiparkinson Agents; Area Under Curve; Humans; Male; Methamphetamine; Models, Biological; Monoamine Oxidase Inhibitors; Pilot Projects; Regression Analysis; Selegiline	1997
Pharmacokinetic evaluation of a selegiline pulsatile oral delivery system. Biopharmaceutics & drug disposition, 1997, Volume: 18, Issue:8 Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Area Under Curve; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Delivery Systems; Humans; Intestinal Absorption; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Pilot Projects; Reference Values; Selegiline; Therapeutic Equivalency; Time Factors	1997
CYP2D6 polymorphism is not crucial for the disposition of selegiline. Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:4 Topics: Adrenergic Agents; Adult; Amphetamines; Area Under Curve; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Humans; In Vitro Techniques; Male; Methamphetamine; Microsomes, Liver; Monoamine Oxidase Inhibitors; Polymorphism, Genetic; Reference Values; Selegiline	1998
Selegiline pharmacokinetics are unaffected by the CYP3A4 inhibitor itraconazole. European journal of clinical pharmacology, 2001, Volume: 57, Issue:1 Topics: Adult; Amphetamines; Antifungal Agents; Area Under Curve; Central Nervous System Stimulants; Confidence Intervals; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Itraconazole; Male; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Selegiline; Statistics, Nonparametric	2001
Effect of concomitant hormone replacement therapy containing estradiol and levonorgestrel on the pharmacokinetics of selegiline. European journal of clinical pharmacology, 2002, Volume: 58, Issue:4 Topics: Administration, Oral; Adult; Amphetamines; Area Under Curve; Cross-Over Studies; Double-Blind Method; Drug Interactions; Estradiol; Estradiol Congeners; Estrogen Replacement Therapy; Female; Humans; Levonorgestrel; Methamphetamine; Monoamine Oxidase Inhibitors; Progesterone Congeners; Selegiline	2002
Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication. Journal of analytical toxicology, 2003, Volume: 27, Issue:3 Topics: Aged; Aged, 80 and over; Amphetamine; Amphetamines; Antiparkinson Agents; Drug Administration Schedule; Female; Hair; Hair Color; Humans; Male; Melanins; Methamphetamine; Middle Aged; Parkinson Disease; Patient Compliance; Selegiline; Spectrophotometry	2003
A new formulation of selegiline: improved bioavailability and selectivity for MAO-B inhibition. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:11 Topics: Administration, Oral; Adult; Aged; Amphetamine; Biological Availability; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Female; Humans; Hydroxyindoleacetic Acid; Male; Metabolic Clearance Rate; Methamphetamine; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Selegiline	2003
A comprehensive assessment of the safety of intravenous methamphetamine administration during treatment with selegiline. Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:4 Topics: Adult; Female; Humans; Infusions, Intravenous; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Placebos; Selegiline; Single-Blind Method	2005
A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. BMC clinical pharmacology, 2009, Aug-01, Volume: 9 Topics: Administration, Cutaneous; Adult; Affect; Amphetamine; Amphetamines; Analysis of Variance; Cocaine; Dopamine Uptake Inhibitors; Drug Interactions; Female; Homovanillic Acid; Humans; Infusions, Intravenous; Male; Methamphetamine; Methoxyhydroxyphenylglycol; Monitoring, Physiologic; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phenethylamines; Prolactin; Selegiline; Statistics, Nonparametric; Substance Withdrawal Syndrome; Young Adult	2009

Other Studies

68 other study(ies) available for methamphetamine and selegiline

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
The effects of deprenyl on methamphetamine-induced dopamine depletions. Journal of neural transmission. General section, 1992, Volume: 89, Issue:1-2 Topics: Animals; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; Parkinson Disease, Secondary; Selegiline; Serotonin	1992
Toxicological detection of selegiline and its metabolites in urine using fluorescence polarization immunoassay (FPIA) and gas chromatography-mass spectrometry (GC-MS) and differentiation by enantioselective GC-MS of the intake of selegiline from abuse of Archives of toxicology, 1992, Volume: 66, Issue:9 Topics: Amphetamine; Fluorescence Polarization Immunoassay; Gas Chromatography-Mass Spectrometry; Humans; Methamphetamine; Selegiline; Stereoisomerism; Substance Abuse Detection	1992
Electron-capture gas chromatographic procedure for simultaneous determination of amphetamine and N-methylamphetamine. Journal of chromatography, 1992, Jan-17, Volume: 573, Issue:2 Topics: Amphetamine; Animals; Chromatography, Gas; Electrons; Gas Chromatography-Mass Spectrometry; Liver; Male; Methamphetamine; Rats; Rats, Inbred Strains; Selegiline	1992
Deprenyl (selegiline), a selective MAO-B inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:2 Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Male; Methamphetamine; Motor Activity; Neurons; Pargyline; Rats; Rats, Inbred Strains; Selegiline; Synaptic Transmission	1991
Evaluation of the effects of inhibition of monoamine oxidase and senescence on methamphetamine-induced neuronal damage. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1991, Volume: 9, Issue:2 Topics: Aging; Animals; Clorgyline; Corpus Striatum; Dopamine; Male; Methamphetamine; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nervous System Diseases; Neurons; Selegiline	1991
Determination of the amine metabolites of selegiline in biological fluids by capillary gas chromatography. Journal of chromatography, 1990, Apr-27, Volume: 527, Issue:1 Topics: Amphetamine; Animals; Chromatography, Gas; Dogs; Methamphetamine; Phenethylamines; Selegiline	1990
Effect of reserpine on the brain uptake of carbon 11 methamphetamine and its N-propagyl derivative, deprenyl. European journal of nuclear medicine, 1990, Volume: 17, Issue:3-4 Topics: Animals; Brain; Carbon Radioisotopes; Male; Methamphetamine; Mice; Reserpine; Selegiline; Tissue Distribution; Tomography, Emission-Computed	1990
Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:5 Topics: Administration, Oral; Adult; Amphetamine; Blood Pressure; Chromatography, Gas; Double-Blind Method; Electrocardiography; Female; Humans; Injections, Intravenous; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Phenethylamines; Phenylacetates; Random Allocation; Selegiline; Tyramine	1989
Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:2 Topics: Amphetamine; Animals; Chromatography, Gas; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxylation; In Vitro Techniques; Male; Methamphetamine; Methimazole; Methylcholanthrene; Microsomes, Liver; Monoamine Oxidase Inhibitors; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline	1986
Effects of d-methamphetamine on monkey brain monoamine oxidase, in vivo and in vitro. Japanese journal of pharmacology, 1987, Volume: 45, Issue:1 Topics: Animals; Brain; Clorgyline; Dextroamphetamine; Female; In Vitro Techniques; Macaca fascicularis; Methamphetamine; Mitochondria; Monoamine Oxidase; Selegiline; Synaptosomes	1987
Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors. Enantiomers of amphetamine, N-methylamphetamine and deprenyl. Biochemical pharmacology, 1985, Dec-01, Volume: 34, Issue:23 Topics: Amphetamine; Animals; Isoenzymes; Kinetics; Liver; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Phenethylamines; Rats; Rats, Inbred Strains; Selegiline; Stereoisomerism	1985
Clinical and pharmacological problems of deprenyl (selegiline) treatment in Parkinson's disease. Acta neurologica Scandinavica. Supplementum, 1983, Volume: 95 Topics: Amphetamine; Humans; Hydrogen-Ion Concentration; Methamphetamine; Parkinson Disease; Phenethylamines; Selegiline	1983
Inhibition of monoamine oxidase by d-methamphetamine. Biochemical pharmacology, 1980, Jul-15, Volume: 29, Issue:14 Topics: Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Methamphetamine; Mitochondria; Monoamine Oxidase Inhibitors; Phenethylamines; Rats; Selegiline; Serotonin; Tyramine	1980
Characterization of N-methylphenylethylamine and N-methylphenylethanolamine as substrates for type A and type B monoamine oxidase. Biochemical pharmacology, 1980, Oct-01, Volume: 29, Issue:19 Topics: 2-Hydroxyphenethylamine; Animals; Brain; Clorgyline; In Vitro Techniques; Kinetics; Male; Methamphetamine; Mitochondria; Monoamine Oxidase; Nerve Tissue Proteins; Phenethylamines; Rats; Selegiline	1980
Metabolism of (-) deprenyl to amphetamine and methamphetamine may be responsible for deprenyl's therapeutic benefit: a biochemical assessment. Neurology, 1982, Volume: 32, Issue:5 Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Amphetamines; Biogenic Amines; Carbidopa; Depression; Drug Combinations; Female; Humans; Levodopa; Male; Methamphetamine; Middle Aged; Monoamine Oxidase; Parkinson Disease; Phenethylamines; Selegiline; Tyramine	1982
The contribution of amphetamine metabolites of (-)-deprenyl to its antiparkinsonian properties. Journal of neural transmission, 1982, Volume: 54, Issue:1-2 Topics: Amphetamine; Double-Blind Method; Drug Therapy, Combination; Humans; Hydrogen-Ion Concentration; Levodopa; Methamphetamine; Middle Aged; Parkinson Disease; Phenethylamines; Selegiline	1982
Hair analysis for drugs of abuse. IX. Comparison of deprenyl use and methamphetamine use by hair analysis. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:2 Topics: Administration, Oral; Adult; Amphetamine; Animals; Gas Chromatography-Mass Spectrometry; Hair; Humans; Illicit Drugs; Male; Methamphetamine; Middle Aged; Rats; Selegiline; Stereoisomerism	1995
Trace decomposition of selegiline. Use of worst-case kinetics for a stable drug. Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:9 Topics: Chromatography, Gas; Chromatography, Liquid; Chromatography, Thin Layer; Drug Stability; Drug Storage; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Methamphetamine; Selegiline; Stereoisomerism; Temperature	1994
Enhanced catecholaminergic and serotoninergic activity in rat brain from weaning to sexual maturity: rationale for prophylactic (-)deprenyl (selegiline) medication. Life sciences, 1995, Volume: 56, Issue:8 Topics: Age Factors; Animals; Brain; Dopamine; Female; Male; Methamphetamine; Norepinephrine; Rats; Rats, Wistar; Selegiline; Serotonin; Sexual Maturation	1995
Sensitive high-performance liquid chromatographic method for the determination of the three main metabolites of selegiline (L-deprenyl) in human plasma. Journal of chromatography. B, Biomedical applications, 1994, Jun-03, Volume: 656, Issue:1 Topics: Amphetamine; Biotransformation; Chromatography, High Pressure Liquid; Fluorenes; Humans; Indicators and Reagents; Methamphetamine; Quality Control; Selegiline	1994
An enzymatic assay for the MAO-B inhibitor selegiline in plasma. Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:7 Topics: Amphetamine; Amphetamines; Animals; Brain; Humans; Hydroxyquinolines; Male; Methamphetamine; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline; Spectrometry, Fluorescence	1994
(-)-Deprenyl alters the survival of adult murine facial motoneurons after axotomy: increases in vulnerable C57BL strain but decreases in motor neuron degeneration mutants. Journal of neuroscience research, 1994, May-01, Volume: 38, Issue:1 Topics: Amphetamine; Animals; Axons; Cell Survival; Facial Nerve; Methamphetamine; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Neurologic Mutants; Motor Neurons; Nerve Degeneration; Selegiline; Species Specificity	1994
Determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. Biological mass spectrometry, 1993, Volume: 22, Issue:4 Topics: Amphetamine; Gas Chromatography-Mass Spectrometry; Humans; Methamphetamine; Quality Control; Regression Analysis; Selegiline	1993
Methamphetamine and amphetamine derived from the metabolism of selegiline. Journal of forensic sciences, 1995, Volume: 40, Issue:6 Topics: Amphetamine; Gas Chromatography-Mass Spectrometry; Humans; Male; Methamphetamine; Selegiline	1995
Gas chromatographic procedure for simultaneous determination of selegiline metabolites, amphetamine, methamphetamine and demethyl-deprenyl in pig plasma. Acta physiologica Hungarica, 1995, Volume: 83, Issue:2 Topics: Amphetamine; Amphetamines; Animals; Capsules; Central Nervous System Stimulants; Chromatography, Gas; Female; Indicators and Reagents; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Swine; Tablets	1995
Capillary electrophoretic enantioseparation of selegiline, methamphetamine and ephedrine using a neutral beta-cyclodextrin epichlorhydrin polymer. Journal of pharmaceutical and biomedical analysis, 1996, Volume: 14, Issue:8-10 Topics: beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Ephedrine; Epichlorohydrin; Hydrogen-Ion Concentration; Illicit Drugs; Indicators and Reagents; Methamphetamine; Osmolar Concentration; Polymers; Selegiline; Stereoisomerism; Temperature	1996
Absorption and presystemic metabolism of selegiline hydrochloride at different regions in the gastrointestinal tract in healthy males. Pharmaceutical research, 1996, Volume: 13, Issue:10 Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Biological Availability; Cross-Over Studies; Duodenum; Gastric Mucosa; Humans; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline	1996
Metabolism of (-)-deprenyl and PF-(-)-deprenyl in brain after central and peripheral administration. Neurochemical research, 1996, Volume: 21, Issue:10 Topics: Amphetamine; Animals; Brain; Corpus Striatum; Gas Chromatography-Mass Spectrometry; Injections, Subcutaneous; Male; Methamphetamine; Microdialysis; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline; Sensitivity and Specificity	1996
Pharmacokinetics and bioequivalence of the main metabolites of selegiline: desmethylselegiline, methamphetamine and amphetamine after oral administration of selegiline. International journal of clinical pharmacology and therapeutics, 1997, Volume: 35, Issue:1 Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Biological Availability; Central Nervous System Stimulants; Half-Life; Humans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Therapeutic Equivalency	1997
Selegiline for the delivery of small doses of amphetamine. The Journal of neuropsychiatry and clinical neurosciences, 1997,Spring, Volume: 9, Issue:2 Topics: Adolescent; Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Child; Child Development Disorders, Pervasive; Humans; Intellectual Disability; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline	1997
Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor. Neuroreport, 1998, Mar-09, Volume: 9, Issue:4 Topics: Animals; Cell Survival; Cells, Cultured; Clorgyline; Dopamine; Embryo, Mammalian; gamma-Aminobutyric Acid; Indans; Mesencephalon; Methamphetamine; Microtubule-Associated Proteins; Monoamine Oxidase Inhibitors; Neurons; Rats; Rats, Sprague-Dawley; Selegiline; Tyrosine 3-Monooxygenase	1998
Gas-chromatographic study on the stereoselectivity of deprenyl metabolism. Journal of pharmaceutical and biomedical analysis, 1998, Volume: 17, Issue:4-5 Topics: Amphetamine; Gas Chromatography-Mass Spectrometry; Humans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Selegiline; Stereoisomerism	1998
l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2 Topics: Animals; Antiparkinson Agents; Caudate Nucleus; Dopamine Agents; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Putamen; Rats; Rats, Sprague-Dawley; Selegiline	1999
Stereochemical determination of selegiline metabolites in postmortem biological specimens. Journal of forensic sciences, 1999, Volume: 44, Issue:1 Topics: Accidents, Aviation; Aged; Amphetamine; Antiparkinson Agents; Autopsy; Gas Chromatography-Mass Spectrometry; Humans; Male; Methamphetamine; Selegiline; Stereoisomerism	1999
Analysis of deprenyl metabolites in the rat brain using HPLC-ES-MS. Current medicinal chemistry, 1999, Volume: 6, Issue:4 Topics: Amphetamine; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Isomerism; Male; Mass Spectrometry; Methamphetamine; Microdialysis; Rats; Rats, Wistar; Selegiline	1999
Stereoselective analyses of selegiline metabolites: possible urinary markers for selegiline therapy. Forensic science international, 1999, Apr-26, Volume: 101, Issue:2 Topics: Adult; Amphetamine; Amphetamines; Biomarkers; Chromatography, Gas; Diagnosis, Differential; Female; Humans; Male; Methamphetamine; Middle Aged; Monoamine Oxidase Inhibitors; Selegiline; Stereoisomerism; Substance Abuse Detection; Substance-Related Disorders	1999
Stereoselective screening for and confirmation of urinary enantiomers of amphetamine, methamphetamine, designer drugs, methadone and selected metabolites by capillary electrophoresis. Electrophoresis, 1999, Volume: 20, Issue:13 Topics: Amphetamine; Antiparkinson Agents; Designer Drugs; Electrophoresis, Capillary; Fluorescence Polarization Immunoassay; Humans; Methadone; Methamphetamine; Reproducibility of Results; Selegiline; Spectrophotometry, Ultraviolet; Stereoisomerism	1999
Metabolic transformation of deprenyl enantiomers in rats. Neurobiology (Budapest, Hungary), 1999, Volume: 7, Issue:2 Topics: Amphetamine; Animals; Dealkylation; Kidney; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Rats; Rats, Wistar; Selegiline; Stereoisomerism	1999
Metabolism of N,N-dialkylated amphetamines, including deprenyl, by CYP2D6 expressed in a human cell line. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:3 Topics: Amphetamine; Amphetamines; Benzphetamine; Cell Line; Chromatography, Gas; Cytochrome P-450 CYP2D6; Humans; Methamphetamine; Methylation; Microsomes; Models, Chemical; Selegiline; Transfection	2000
Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes. Pharmacology & toxicology, 2000, Volume: 86, Issue:5 Topics: Amphetamines; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluvoxamine; Humans; Ketoconazole; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Selegiline; Theophylline	2000
Anti-apoptotic and apoptotic action of (-)-deprenyl and its metabolites. Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:1 Topics: Adrenergic Agents; Apoptosis; Caspase 3; Caspases; Cell Survival; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Melanoma; Methamphetamine; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Proadifen; Selegiline; Tumor Cells, Cultured	2001
Biphasic effects of selegiline on striatal dopamine: lack of effect on methamphetamine-induced dopamine depletion. Neurochemical research, 2001, Volume: 26, Issue:1 Topics: Animals; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Male; Methamphetamine; Mice; Monoamine Oxidase Inhibitors; Neurotoxins; Selegiline	2001
Incorporation of selegiline metabolites into hair after oral selegiline intake. Journal of analytical toxicology, 2001, Volume: 25, Issue:7 Topics: Administration, Oral; Adult; Amphetamine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Melanins; Methamphetamine; Monoamine Oxidase Inhibitors; Selegiline; Sensitivity and Specificity; Substance Abuse Detection	2001
Urinary excretion of selegiline N-oxide, a new indicator for selegiline administration in man. Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:9 Topics: Adrenergic Uptake Inhibitors; Adult; Amphetamine; Amphetamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Methamphetamine; Models, Chemical; Monoamine Oxidase Inhibitors; Selegiline; Spectrometry, Mass, Electrospray Ionization; Time Factors	2002
Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine, and amphetamine) in human plasma by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Journal of analytical toxicology, 2002, Volume: 26, Issue:7 Topics: Amphetamine; Amphetamines; Chromatography, High Pressure Liquid; Freezing; Humans; Mass Spectrometry; Methamphetamine; Monoamine Oxidase Inhibitors; Reproducibility of Results; Selegiline	2002
Reduced cardiovascular effects of methamphetamine following treatment with selegiline. Drug and alcohol dependence, 2003, Nov-24, Volume: 72, Issue:2 Topics: Animals; Blood Pressure; Central Nervous System Stimulants; Drug Tolerance; Electrocardiography; Heart Rate; Injections, Intravenous; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Saimiri; Selegiline	2003
Analysis of benzene ethylamine derivatives in urine using the programmable dynamic liquid-phase microextraction (LPME) device. The Analyst, 2003, Volume: 128, Issue:12 Topics: Benzene Derivatives; Bupropion; Electronic Data Processing; Ephedrine; Ethylamines; Humans; Mephentermine; Methamphetamine; Microchemistry; Reproducibility of Results; Selegiline; Sensitivity and Specificity; Substance Abuse Detection	2003
Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline. British journal of pharmacology, 2004, Volume: 143, Issue:3 Topics: Administration, Oral; Animals; Blood Flow Velocity; Blood Pressure; Cardiovascular Physiological Phenomena; Carotid Arteries; Indans; Injections, Intravenous; Methamphetamine; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selegiline; Time Factors; Vascular Resistance	2004
Assessment of the N-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: an in vitro metabolism study. Electrophoresis, 2004, Volume: 25, Issue:16 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Amphetamine; beta-Cyclodextrins; Buffers; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Methamphetamine; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Oxygenases; Recombinant Proteins; Selegiline; Stereoisomerism	2004
Inhibition of methamphetamine-induced hyperlocomotion in mice by clorgyline, a monoamine oxidase-a inhibitor, through alteration of the 5-hydroxytriptamine turnover in the striatum. Neuroscience, 2005, Volume: 130, Issue:2 Topics: Animals; Clorgyline; Corpus Striatum; Dose-Response Relationship, Drug; Drug Administration Schedule; Hyperkinesis; Male; Methamphetamine; Mice; Mice, Inbred ICR; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neural Pathways; Nucleus Accumbens; Selegiline; Serotonin	2005
Discriminative stimulus and reinforcing effects of p-fluoro-L-deprenyl in monkeys. Psychopharmacology, 2005, Volume: 182, Issue:1 Topics: Amphetamine-Related Disorders; Amphetamines; Animals; Association Learning; Central Nervous System Stimulants; Cocaine; Conditioning, Classical; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Stimulus; Injections, Intramuscular; Injections, Intravenous; Methamphetamine; Motivation; Reinforcement Schedule; Saimiri; Selegiline; Self Administration; Structure-Activity Relationship	2005
Effects of monoamine oxidase inhibitors on methamphetamine-induced stereotypy in mice and rats. Neurochemical research, 2005, Volume: 30, Issue:11 Topics: Animals; Behavior, Animal; Biogenic Monoamines; Central Nervous System Stimulants; Clorgyline; Male; Methamphetamine; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Rats; Rats, Wistar; Selegiline; Stereotyped Behavior	2005
High-performance liquid chromatographic-mass spectrometric determination of methamphetamine and amphetamine enantiomers, desmethylselegiline and selegiline, in hair samples of long-term methamphetamine abusers or selegiline users. Journal of analytical toxicology, 2006, Volume: 30, Issue:4 Topics: Amphetamine; Amphetamines; Antiparkinson Agents; Chromatography, High Pressure Liquid; Hair; Humans; Methamphetamine; Parkinson Disease; Selegiline; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection	2006
L-methamphetamine and selective MAO inhibitors decrease morphine-reinforced and non-reinforced behavior in rats; Insights towards selegiline's mechanism of action. Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:4 Topics: Animals; Behavior, Animal; Body Weight; Central Nervous System Stimulants; Clorgyline; Conditioning, Operant; Extinction, Psychological; Indans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Morphine; Morphine Dependence; Rats; Rats, Wistar; Reinforcement, Psychology; Selegiline; Self Administration; Substance Withdrawal Syndrome	2006
P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:2 Topics: Amphetamines; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Methamphetamine; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Monoamine Oxidase Inhibitors; Oxidoreductases, N-Demethylating; Phenotype; Recombinant Proteins; Selegiline; Tandem Mass Spectrometry	2007
Deprenyl treatment attenuates long-term pre- and post-synaptic changes evoked by chronic methamphetamine. European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Blotting, Western; Body Weight; Caudate Nucleus; Chromatography, High Pressure Liquid; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Immunochemistry; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Mesencephalon; Methamphetamine; Phosphorylation; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Selegiline; Substantia Nigra; Synapses; Time Factors; Tyrosine 3-Monooxygenase	2007
Differential behavioral syndrome evoked in the rats after multiple doses of SSRI fluoxetine with selective MAO inhibitors rasagiline or selegiline. Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:1 Topics: Animals; Behavior, Animal; Brain; Drug Therapy, Combination; Fluoxetine; Indans; Male; Methamphetamine; Monoamine Oxidase Inhibitors; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Selegiline; Serotonin Syndrome	2008
Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse. Journal of neural transmission. Supplementum, 2007, Issue:72 Topics: Administration, Oral; Amphetamine; Amphetamines; Animals; Antiparkinson Agents; Biological Availability; Biotransformation; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Metabolic Clearance Rate; Methamphetamine; Mice; Mice, Inbred Strains; Monoamine Oxidase Inhibitors; Selegiline	2007
Detection of levorotatory methamphetamine and levorotatory amphetamine in urine after ingestion of an overdose of selegiline. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2008, Volume: 128, Issue:10 Topics: Adult; Amphetamine; Biomarkers; Drug Overdose; Gas Chromatography-Mass Spectrometry; Humans; Male; Methamphetamine; Parkinson Disease; Selegiline; Suicide, Attempted	2008
Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996), 2013, Volume: 120, Issue:5 Topics: Aged; Amphetamine; Antiparkinson Agents; Drug Substitution; Female; Humans; Indans; Male; Methamphetamine; Middle Aged; Motor Activity; Neuroprotective Agents; Parkinson Disease; Selegiline; Severity of Illness Index; Time Factors	2013
Rasagiline, a suicide inhibitor of monoamine oxidases, binds reversibly to α-synuclein. ACS chemical neuroscience, 2015, Feb-18, Volume: 6, Issue:2 Topics: alpha-Synuclein; Calorimetry; Indans; Methamphetamine; Monoamine Oxidase Inhibitors; Nanopores; Neuroprotective Agents; Protein Binding; Selegiline	2015
[Identification of Methamphetamine Abuse and Selegiline Use： Chiral Analysis of Methamphetamine and Amphetamine in Urine]. Fa yi xue za zhi, 2017, Volume: 33, Issue:6 Topics: Amphetamine; Amphetamine-Related Disorders; Central Nervous System Stimulants; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Methamphetamine; Selegiline; Substance Abuse Detection; Tandem Mass Spectrometry	2017
Pharmacokinetics of selegiline, R-methamphetamine, R-amphetamine, and desmethylselegiline in oral fluid after a single oral administration of selegiline. Drug testing and analysis, 2019, Volume: 11, Issue:6 Topics: Administration, Oral; Amphetamine; Amphetamines; Humans; Liquid-Liquid Extraction; Methamphetamine; Monoamine Oxidase Inhibitors; Saliva; Selegiline; Substance Abuse Detection	2019
Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites. Journal of analytical toxicology, 2021, Feb-06, Volume: 45, Issue:1 Topics: Amphetamine; Central Nervous System Stimulants; Gas Chromatography-Mass Spectrometry; Humans; Methamphetamine; Republic of Korea; Selegiline; Substance Abuse Detection	2021