methamphetamine and acetylcysteine

methamphetamine has been researched along with acetylcysteine in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (33.33)29.6817
2010's12 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Fukumoto, D; Hashimoto, K; Iyo, M; Kakiuchi, T; Nishiyama, S; Shimizu, E; Tsukada, H2
Fukami, G; Hashimoto, K; Iyo, M; Koike, K; Okamura, N; Shimizu, E1
Achat-Mendes, C; Anderson, KL; Itzhak, Y1
Banerjee, A; Banks, WA; Ercal, N; Zhang, X1
Banerjee, A; Banks, WA; Ercal, N; Manda, KR; Zhang, X1
Grant, JE; Kim, SW; Odlaug, BL1
Largeron, M; Martinez, CM; McCann, U; Mechan, A; Mueller, M; Neudörffer, A; Ricaurte, GA1
Ercal, N; Tobwala, S; Zhang, X1
Karimian Sichani, N; Maracy, M; Mousavi, SG; Peykanpour, M; Salehi, M; Sharbafchi, MR1
Baker, AL; Berk, M; Carter, G; Dean, OM; Kelly, PJ; McKetin, R; Turner, A1
Amaral, C; Bastos, ML; Carvalho, F; Carvalho, M; Correia-da-Silva, G; Duarte, JA; Guedes de Pinho, P; Valente, MJ1
Bevins, RA; Charntikov, S; Pittenger, ST; Pudiak, CM1
Huang, J; Li, J; Li, Q; Li, SB; Li, Z; Lu, G; Sham, PC; Wong, N; Yang, G; Zeng, XF1
Arunogiri, S; Baker, AL; Bathish, R; Berk, M; Carter, G; Cordaro, F; Dean, OM; Dietze, P; Higgs, P; Hill, H; Kelly, PJ; Kent, M; Liang, W; Lubman, DI; Manning, V; McKetin, R; Quinn, B; Raftery, D; Reid, D; Sinclair, B; Te Pas, N; Thomas, T; Turner, A1

Reviews

1 review(s) available for methamphetamine and acetylcysteine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

3 trial(s) available for methamphetamine and acetylcysteine

ArticleYear
A double-blind, placebo-controlled study of N-acetyl cysteine plus naltrexone for methamphetamine dependence.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2010, Volume: 20, Issue:11

    Topics: Acetylcysteine; Adult; Amphetamine-Related Disorders; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methamphetamine; Middle Aged; Naltrexone; Young Adult

2010
The efficacy of N-acetylcysteine in the treatment of methamphetamine dependence: a double-blind controlled, crossover study.
    Archives of Iranian medicine, 2015, Volume: 18, Issue:1

    Topics: Acetylcysteine; Adult; Amphetamine-Related Disorders; Central Nervous System Stimulants; Craving; Cross-Over Studies; Double-Blind Method; Female; Free Radical Scavengers; Humans; Male; Methamphetamine; Substance Withdrawal Syndrome; Surveys and Questionnaires; Treatment Outcome; Young Adult

2015
A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine ("ice") dependence.
    Trials, 2019, Jun-04, Volume: 20, Issue:1

    Topics: Acetylcysteine; Adolescent; Adult; Amphetamine-Related Disorders; Australia; Central Nervous System Stimulants; Clinical Trials, Phase II as Topic; Craving; Double-Blind Method; Female; Humans; Male; Methamphetamine; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Substance Abuse, Intravenous; Time Factors; Treatment Outcome; Young Adult

2019

Other Studies

14 other study(ies) available for methamphetamine and acetylcysteine

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Protective effects of N-acetyl-L-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:11

    Topics: Acetylcysteine; Animals; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Nerve Tissue Proteins; Neuroprotective Agents; Positron-Emission Tomography

2004
Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine.
    Brain research, 2004, Jul-30, Volume: 1016, Issue:1

    Topics: Acetylcysteine; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Free Radical Scavengers; Male; Methamphetamine; Neurotoxicity Syndromes; Rats; Time Factors

2004
Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine.
    Annals of the New York Academy of Sciences, 2004, Volume: 1025

    Topics: Acetylcysteine; Animals; Antioxidants; Dopamine Plasma Membrane Transport Proteins; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Methamphetamine; Nerve Tissue Proteins

2004
Impairment in consolidation of learned place preference following dopaminergic neurotoxicity in mice is ameliorated by N-acetylcysteine but not D1 and D2 dopamine receptor agonists.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:3

    Topics: Acetylcysteine; Animals; Behavior, Animal; Brain Chemistry; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione; Learning Disabilities; Male; Methamphetamine; Mice; Neurotoxicity Syndromes; Tyrosine 3-Monooxygenase

2007
N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells.
    Brain research, 2009, Jun-12, Volume: 1275

    Topics: Acetylcysteine; Brain; Cell Line, Transformed; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Humans; Methamphetamine; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species

2009
HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide.
    Free radical biology & medicine, 2010, May-15, Volume: 48, Issue:10

    Topics: Acetylcysteine; AIDS Dementia Complex; Animals; Antioxidants; Blood-Brain Barrier; Brain; Glutathione Disulfide; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Illicit Drugs; Malondialdehyde; Methamphetamine; Mice; Mice, Inbred Strains; Oxidative Stress; Risk Factors; tat Gene Products, Human Immunodeficiency Virus; Tight Junctions

2010
Synthesis and neurotoxicity profile of 2,4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate.
    Chemical research in toxicology, 2011, Jun-20, Volume: 24, Issue:6

    Topics: Acetylcysteine; Adrenergic Uptake Inhibitors; Animals; Brain; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin

2011
N-acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice.
    Human & experimental toxicology, 2012, Volume: 31, Issue:9

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Catalase; Central Nervous System Stimulants; Glutathione; Glutathione Peroxidase; Kidney; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methamphetamine; Mice; Oxidative Stress; Protein Carbonylation

2012
A potential role for N-acetylcysteine in the management of methamphetamine dependence.
    Drug and alcohol review, 2017, Volume: 36, Issue:2

    Topics: Acetylcysteine; Amphetamine-Related Disorders; Antioxidants; Australia; Brain; Glutamic Acid; Humans; Methamphetamine

2017
Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of β-keto amphetamines-related neurotoxicity.
    Archives of toxicology, 2017, Volume: 91, Issue:11

    Topics: Acetylcysteine; Amphetamines; Apoptosis; Autophagy; Benzodioxoles; Cell Line; Central Nervous System Stimulants; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Dose-Response Relationship, Drug; Humans; Methamphetamine; Microtubule-Associated Proteins; Neurotoxicity Syndromes; Oxidative Stress; Pyrrolidines; Synthetic Cathinone

2017
The effect of N-acetylcysteine or bupropion on methamphetamine self-administration and methamphetamine-triggered reinstatement of female rats.
    Neuropharmacology, 2018, Volume: 135

    Topics: Acetylcysteine; Amphetamine-Related Disorders; Animals; Bupropion; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Estrous Cycle; Female; Methamphetamine; Motor Activity; Psychotropic Drugs; Rats, Sprague-Dawley; Self Administration

2018
HIV-1 Tat and methamphetamine co-induced oxidative cellular injury is mitigated by N-acetylcysteine amide (NACA) through rectifying mTOR signaling.
    Toxicology letters, 2018, Dec-15, Volume: 299

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Humans; Male; Methamphetamine; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; tat Gene Products, Human Immunodeficiency Virus; TOR Serine-Threonine Kinases

2018