methadyl acetate has been researched along with paracymethadol in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (37.50) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khazan, N; Steinfels, GF; Young, GA | 1 |
| Gibson, A; Vernadakis, A | 1 |
| DePace, A; Mulé, SJ; Verebey, K | 1 |
| Kuwahara, MD; Sparber, SB | 2 |
| Freeman, RW; Harbison, RD; James, RC | 1 |
| Bartolomeo, JG; Bates, TR; Bloch, R; Misra, AL; Mulé, SJ | 1 |
| Finkle, BS; Lichtblau, L; Sparber, SB | 1 |
| Harbison, RD; James, RC | 1 |
| Cook, CE; Jeffcoat, AR; Mathews, JM; Myers, MW; Thomas, BF | 1 |
| Alburges, ME; Crouch, DJ; Foltz, RL; Minear, K; Moody, DE; Sakashita, CO; Schulthies, JE | 1 |
| Krueger, GG; Rollins, DE; Valdez, AS; Wilkins, DG | 1 |
| Jasinski, DR; Vaupel, DB | 1 |
| Alburges, ME; Collins, JM; Moody, DE; Parker, RJ; Strong, JM | 1 |
| Fiellin, DA; O'Connor, PG | 1 |
| Kharasch, ED; Oda, Y | 1 |
| Moody, DE; Neff, JA | 1 |
| Baumgart, MI; Schrott, LM; Sparber, SB; Zhang, X | 1 |
| Bemis, PA; Huang, W; Moody, DE; Slawson, MH | 1 |
| Chen, XL; Kang, J; Rampe, D; Wang, H | 1 |
| Ahmed, MS; Burmaster, S; Deshmukh, SV; Miles, R; Nanovskaya, TN | 1 |
| Ahmed, MS; Deshmukh, SV; Hankins, GD; Nanovskaya, TN | 1 |
| Schrott, LM; Sparber, SB | 1 |
| Bochner, F; Newcombe, DAL; Somogyi, AA; White, JM | 1 |
1 review(s) available for methadyl acetate and paracymethadol
| Article | Year |
|---|---|
Pharmacologic treatment of heroin-dependent patients.
Topics: Analgesics, Opioid; Buprenorphine; Counseling; Heroin Dependence; Humans; Mental Disorders; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Physician's Role; Substance Withdrawal Syndrome | 2000 |
1 trial(s) available for methadyl acetate and paracymethadol
| Article | Year |
|---|---|
Impaired psychomotor function and plasma methadone and levo-alpha-acetylmethadol (LAAM) concentrations in opioid-substitution patients.
Topics: Adult; Drug Tolerance; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opiate Substitution Treatment; Opioid-Related Disorders; Psychomotor Performance; Time Factors; Young Adult | 2017 |
22 other study(ies) available for methadyl acetate and paracymethadol
| Article | Year |
|---|---|
Opioid self-administration and REM sleep EEG power spectra.
Topics: Animals; Electroencephalography; Female; Methadone; Methadyl Acetate; Morphine; Narcotics; Rats; Self Administration; Sleep, REM | 1979 |
Neurotoxicity of opiates during brain development: in vivo and in vitro studies.
Topics: Abnormalities, Drug-Induced; Animals; Binding Sites; Brain; Cells, Cultured; Chick Embryo; Etorphine; In Vitro Techniques; Methadone; Methadyl Acetate; Neurons; Receptors, Opioid; Tritium | 1985 |
Quantitation of l-alpha-acetylmethadol and its metabolites in human serum by capillary gas-liquid chromatography and nitrogen detection.
Topics: Chromatography, Gas; Drug Stability; Humans; Methadone; Methadyl Acetate; Time Factors | 1985 |
Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.
Topics: Animals; Brain; Chick Embryo; DNA; Methadone; Methadyl Acetate; Nerve Tissue Proteins; Organ Size; RNA | 1981 |
Opiate withdrawal increases ornithine decarboxylase activity which is otherwise unaltered in brains of dependent chicken fetuses.
Topics: Animals; Brain; Carboxy-Lyases; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Ornithine Decarboxylase; Substance Withdrawal Syndrome | 1983 |
L-alpha-acetylmethadol-induced tissue alterations in mice.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Glutathione; Kidney; Liver; Male; Methadone; Methadyl Acetate; Methylcholanthrene; Mice; Mice, Inbred ICR; Necrosis; Phenobarbital; Time Factors | 1984 |
Pharmacokinetics and metabolism of l-alpha-[O,O'-3H2]-acetyl normethadol (nor-LAAM), the active metabolite of LAAM, in acutely and chronically treated rhesus monkeys.
Topics: Administration, Oral; Animals; Behavior, Animal; Biological Availability; Biotransformation; Haplorhini; Injections, Intravenous; Kinetics; Macaca mulatta; Methadone; Methadyl Acetate; Time Factors | 1980 |
Cumulation of active metabolites of levo-alpha-acetylmethadol in the rat fetus and neonate.
Topics: Animals; Animals, Newborn; Brain; Female; Fetus; Maternal-Fetal Exchange; Methadone; Methadyl Acetate; Pregnancy; Rats; Rats, Inbred Strains | 1982 |
Hepatic glutathione and hepatotoxicity: effects of cytochrome P-450 complexing compounds SKF 525-A, L-alpha acetylmethadol (LAAM), norLAAM, and piperonyl butoxide.
Topics: Alanine Transaminase; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; Liver; Male; Mesocricetus; Methadone; Methadyl Acetate; Mice; Mixed Function Oxygenases; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains | 1982 |
Determination of l-alpha-acetylmethadol, l-alpha-noracetylmethadol and l-alpha-dinoracetylmethadol in plasma by gas chromatography-mass spectrometry.
Topics: Animals; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Methadyl Acetate; Quality Control; Rats | 1994 |
A gas chromatographic-positive ion chemical ionization-mass spectrometric method for the determination of I-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in plasma, urine, and tissue.
Topics: Acetic Anhydrides; Analgesics, Opioid; Animals; Brain; Buffers; Butanes; Calibration; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Humans; Liver; Methadyl Acetate; Methanol; Microsomes, Liver; Protein Denaturation; Rats; Reference Standards; Reproducibility of Results; Species Specificity; Tissue Distribution; Trifluoroacetic Acid | 1995 |
Quantitative analysis of l-alpha-acetylmethadol, l-alpha-acetyl-N-normethadol, and l-alpha-acetyl-N,N-dinormethadol in human hair by positive ion chemical ionization mass spectrometry.
Topics: Animals; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Mass Spectrometry; Methadyl Acetate; Narcotics; Quality Control; Rats; Reference Standards; Solvents | 1997 |
l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog.
Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1997 |
The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dimethylamines; DNA, Complementary; Enzyme Inhibitors; Humans; Isoenzymes; Methadone; Methadyl Acetate; Microsomes, Liver; Mixed Function Oxygenases; Substrate Specificity | 1997 |
Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites.
Topics: Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Humans; Kinetics; Methadyl Acetate; Microsomes, Liver; Mixed Function Oxygenases; Narcotics; Oxidoreductases, N-Demethylating | 2001 |
Differential N-demethylation of l-alpha-acetylmethadol (LAAM) and norLAAM by cytochrome P450s 2B6, 2C18, and 3A4.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Liver; Methadyl Acetate; Methylation; Microsomes; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Spodoptera; Transfection | 2001 |
Prenatal opiate withdrawal activates the chick embryo hypothalamic pituitary-adrenal axis and dilates vitelline blood vessels via serotonin(2) receptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chick Embryo; Corticosterone; Disease Models, Animal; Hypothalamo-Hypophyseal System; Methadyl Acetate; Morphogenesis; Naloxone; Narcotics; Pituitary-Adrenal System; Receptors, Serotonin; Ritanserin; Substance Withdrawal Syndrome | 2002 |
Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometry.
Topics: Adult; Chromatography, Liquid; Female; Humans; Male; Methadyl Acetate; Spectrometry, Mass, Electrospray Ionization | 2003 |
Interactions of the narcotic l-alpha-acetylmethadol with human cardiac K+ channels.
Topics: Animals; Cation Transport Proteins; CHO Cells; Cricetinae; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Membrane Potentials; Methadyl Acetate; Narcotics; Potassium Channels; Potassium Channels, Voltage-Gated; Trans-Activators; Transcriptional Regulator ERG | 2003 |
Transfer of L-alpha-acetylmethadol (LAAM) and L-alpha-acetyl-N-normethadol (norLAAM) by the perfused human placental lobule.
Topics: Adult; Analgesics, Opioid; Female; Fetus; Humans; Methadyl Acetate; Placenta; Pregnancy | 2003 |
N-demethylation of levo-alpha-acetylmethadol by human placental aromatase.
Topics: Aromatase; Female; Humans; In Vitro Techniques; Kinetics; Methadyl Acetate; Methylation; Placenta; Pregnancy; Subcellular Fractions | 2004 |
Suppressed fever and hypersensitivity responses in chicks prenatally exposed to opiates.
Topics: Analysis of Variance; Animals; Basophils; Chick Embryo; Chickens; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Embryonic Development; Female; Fever; Hypersensitivity; Hypothalamo-Hypophyseal System; Lipopolysaccharides; Methadyl Acetate; Narcotics; Neuroimmunomodulation; Ovum; Skin; Substance Withdrawal Syndrome; Toxicity Tests, Acute; Toxicity Tests, Chronic | 2004 |