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methadyl acetate and morphine

methadyl acetate has been researched along with morphine in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199038 (90.48)18.7374
1990's3 (7.14)18.2507
2000's1 (2.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goldstein, MG; Sollod, RM1
Howd, RA; Pryor, GT1
Khazan, N; Steinfels, GF; Young, GA2
Dorus, W; Renault, PF; Senay, EC1
Charuvastra, VC; Ouren, J; Panell, J1
Chiba, S; Khazan, N; Moreton, JE; Young, GA1
Downs, DA; Harrigan, SE1
Holtzman, SG1
Eikenburg, DC; Stickney, JL1
Downs, DA; Wiley, JN1
Jakubovic, A; McGeer, EG1
Chiba, S; Khazan, N; Moreton, EJ1
Masten, LW1
Aigner, TG; Balster, RL; Ford, RD1
Chen, RC; Ho, AK; Ho, CC1
Blachly, P; Carter, CC; Irwin, S; Marks, J1
Charuvastra, VC; Kaim, SC; Klett, CJ; Ling, W1
Archer, S1
Brocco, MJ; Killam, KF; Robinson, CA1
Stickney, JL1
Berkowitz, BA; Lee, CH1
Chen, RC; Ho, AK1
Henderson, GL; Rosenkranz, RP1
McCarthy, DA; McLean, JR; Nuite, JA; Tessman, DK; Wax, J1
Harbison, RD; James, RC; Roberts, SM; Skoulis, NP1
Amsterdam, EA; Henderson, GL; Mason, DT; Rendig, SV1
Harris, GJ; Hasegawa, AT; Lynch, KL; Roerig, DL; Wang, RI1
Jeziorski, K; Matsumoto, H1
Dewey, WL1
Brocco, M; McMillan, DE1
Khazan, N; Lukas, SE; Moreton, JE3
Fraser, HF; Gorodetzky, CW; Kay, DC; Yeh, SY1
Burklund, KE; Lichtblau, L; Sparber, SB1
Steinfels, GF; Young, GA1
Khazan, N; Steinfels, GF; Wolf, DL; Young, GA1
Chuang, LF; Chuang, RY; Killam, KF; Kung, HF; Li, Y1
Brandt, MR; Cabansag, SR; France, CP1
Jasinski, DR; Vaupel, DB1
France, CP; McMahon, LR; Sell, SL1

Reviews

4 review(s) available for methadyl acetate and morphine

ArticleYear
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
    NIDA research monograph, 1976, Issue:8

    Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors

1976
Pharmacology of LAAM.
    NIDA research monograph, 1976, Issue:8

    Topics: Analgesics; Animals; Behavior, Animal; Dogs; Drug Evaluation, Preclinical; Female; Haplorhini; Humans; Kinetics; Male; Methadone; Methadyl Acetate; Mice; Morphine; Nalorphine; Rabbits; Rats; Stereoisomerism; Substance-Related Disorders; Time Factors

1976
[Treatment of opiate withdrawal syndromes (historical review)].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1984, Oct-22, Volume: 39, Issue:43

    Topics: Antipsychotic Agents; Clonidine; Drug Evaluation; History, 19th Century; History, 20th Century; Humans; Methadone; Methadyl Acetate; Morphine; Narcotic Antagonists; Phenothiazines; Substance Withdrawal Syndrome

1984
Possible influence of opioid normetabolites on the onset, magnitude and quality of the opioid abstinence syndrome.
    Drug and alcohol dependence, 1980, Volume: 5, Issue:4

    Topics: Administration, Oral; Animals; Biotransformation; Body Weight; Codeine; Dealkylation; Dextropropoxyphene; Dogs; Guinea Pigs; Humans; Injections, Subcutaneous; Levorphanol; Meperidine; Methadyl Acetate; Morphine; Narcotics; Rabbits; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1980

Trials

5 trial(s) available for methadyl acetate and morphine

ArticleYear
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
    NIDA research monograph, 1976, Issue:8

    Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors

1976
Methadyl acetate and methadone. An open comparison.
    JAMA, 1977, Jan-10, Volume: 237, Issue:2

    Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Morphine; Substance Withdrawal Syndrome

1977
Methadyl acetate versus methadone: the experience of one hospital.
    The Medical journal of Australia, 1977, Jul-30, Volume: 2, Issue:5

    Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Morphine; Patient Dropouts

1977
Preliminary observations with acute and chronic methadone and 1-alpha-acetylmethadol administration in humans.
    NIDA research monograph, 1976, Issue:8

    Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Tolerance; Female; Humans; Male; Methadone; Methadyl Acetate; Morphine; Substance-Related Disorders; Time Factors

1976
Summary of Veterans Administration Phase II cooperative study for LAAM and methadone.
    NIDA research monograph, 1976, Issue:8

    Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Middle Aged; Morphine; Patient Dropouts; Self Administration; United States; United States Department of Veterans Affairs

1976

Other Studies

34 other study(ies) available for methadyl acetate and morphine

ArticleYear
Effects of chronic treatment with morphine, methadone, and LAAM on the response to phencyclidine in rats.
    NIDA research monograph, 1979, Volume: 27

    Topics: Animals; Behavior, Animal; Drug Synergism; Humans; Male; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Phencyclidine; Rats

1979
Opioid self-administration and REM sleep EEG power spectra.
    NIDA research monograph, 1979, Volume: 27

    Topics: Animals; Electroencephalography; Female; Methadone; Methadyl Acetate; Morphine; Narcotics; Rats; Self Administration; Sleep, REM

1979
Head-shake distributions during self-maintained dependence on morphine, methadone, and l-alpha-acetylmethadol (LAAM) in the rat.
    Psychopharmacology, 1977, Aug-31, Volume: 54, Issue:1

    Topics: Animals; Behavior, Animal; Female; Humans; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Rats; Self Administration; Substance-Related Disorders

1977
Self-administration of heroin, acetylmethadol, morphine, and methadone in rhesus monkeys.
    Life sciences, 1978, Volume: 22, Issue:7

    Topics: Animals; Behavior, Animal; Haplorhini; Heroin; Injections, Intravenous; Macaca mulatta; Methadone; Methadyl Acetate; Morphine; Narcotics; Respiration; Self Administration

1978
Discriminative stimulus properties of levo-alpha-acetylmethadol and its metabolites.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:4

    Topics: Animals; Discrimination, Psychological; Male; Methadone; Methadyl Acetate; Morphine; Rats; Time Factors

1979
Anti-cholinesterase activity of 1-alpha-acetylmethadol: relationship to bradycardia.
    General pharmacology, 1979, Volume: 10, Issue:3

    Topics: Acetylcholinesterase; Animals; Bethanechol Compounds; Bradycardia; Butyrylcholinesterase; Cholinesterase Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Methadone; Methadyl Acetate; Morphine; Myocardium; Physostigmine

1979
Naloxone-precipitated jumping in mice pretreated with acute injections of opioids.
    Life sciences, 1979, Aug-27, Volume: 25, Issue:9

    Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Enkephalins; Heroin; Male; Methadone; Methadyl Acetate; Mice; Morphine; Naloxone; Narcotics; Pentazocine

1979
Narcotics and rat testicular metabolism.
    Molecular pharmacology, 1979, Volume: 16, Issue:3

    Topics: Animals; Codeine; DNA; Heroin; In Vitro Techniques; Leydig Cells; Male; Methadyl Acetate; Morphine; Naloxone; Narcotics; Protein Biosynthesis; Rats; RNA; Testis; Testosterone

1979
Tolerance and cross tolerance to toxic effects of morphine, methadone and 1-alpha-acetylmethadol (LAAM) in naive and morphine dependent rats.
    Japanese journal of pharmacology, 1978, Volume: 28, Issue:3

    Topics: Animals; Cross Reactions; Drug Tolerance; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Substance-Related Disorders

1978
Development of cellular tolerance to lethality and analgesia concurrent with physical dependence following repeated oral administration of LAAM.
    Drug and alcohol dependence, 1979, Volume: 4, Issue:5

    Topics: Administration, Oral; Animals; Drug Tolerance; Humans; Injections, Intraventricular; Lethal Dose 50; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred ICR; Morphine; Naloxone; Nociceptors; Opioid-Related Disorders

1979
levo-Alpha-acetylmethadol and metabolites: some effects on schedule-controlled behavior in the rat.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 8, Issue:6

    Topics: Animals; Behavior, Animal; Male; Methadone; Methadyl Acetate; Morphine; Rats; Reinforcement Schedule; Time Factors

1978
Interaction toxicity between ethanol and narcotics in mice with reference to alpha-1-acetylmethadol (LAAM).
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:2

    Topics: Animals; Brain; Dextrorphan; Drug Interactions; Ethanol; Lethal Dose 50; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Morphine; Narcotics

1978
Evaluation of narcotic and narcotic antagonist interactions in primates.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration

1976
Cardiac effects of 1-alpha-acetylmethadol. I. Chronotropic effects in vitro.
    Toxicology and applied pharmacology, 1977, Volume: 40, Issue:1

    Topics: Animals; Drug Interactions; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Methacholine Compounds; Methadone; Methadyl Acetate; Morphine; Naloxone; Norepinephrine

1977
Calcium antagonist activity of methadone, l-acetylmethadol and l-pentazocine in the rat aortic strip.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:3

    Topics: Animals; Aorta, Thoracic; Calcium; Drug Interactions; In Vitro Techniques; Male; Methadone; Methadyl Acetate; Morphine; Muscle Contraction; Muscle, Smooth; Pentazocine; Rats; Stereoisomerism

1977
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1976
Renal toxicity of l-alpha-acetylmethadol (LAAM) in the rat.
    Proceedings of the Western Pharmacology Society, 1975, Volume: 18

    Topics: Animals; Hematuria; Kidney Diseases; Kidney Tubules; Methadone; Methadyl Acetate; Morphine; Naloxone; Nephrosis; Phenobarbital; Rats; Time Factors

1975
Duration of antinociceptive action of morphine, methadone and alpha-l-acetylmethadol subcutaneously in rats.
    Research communications in chemical pathology and pharmacology, 1975, Volume: 12, Issue:4

    Topics: Analgesia; Animals; Injections, Subcutaneous; Male; Methadone; Methadyl Acetate; Morphine; Rats; Reaction Time; Time Factors; Vocalization, Animal

1975
Depression of hepatic glutathione by opioid analgesic drugs in mice.
    Toxicology and applied pharmacology, 1989, Jun-01, Volume: 99, Issue:1

    Topics: Alanine Transaminase; Analgesics, Opioid; Animals; Depression, Chemical; Ethylmorphine; Female; Glutathione; Hydromorphone; Liver; Male; Meperidine; Methadyl Acetate; Mice; Mice, Inbred ICR; Morphine; Sex Factors

1989
Comparative cardiac contractile actions of six narcotic analgesics: morphine, meperidine, pentazocine, fentanyl, methadone and l-alpha-acetylmethadol (LAAM).
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:1

    Topics: Analgesics, Opioid; Animals; Cats; Depression, Chemical; Drug Interactions; Fentanyl; Meperidine; Methadone; Methadyl Acetate; Morphine; Myocardial Contraction; Naloxone; Pentazocine; Stimulation, Chemical

1980
Occurrence of corneal opacities in rats after acute administration of l-alpha-acetylmethadol.
    Toxicology and applied pharmacology, 1980, Volume: 56, Issue:2

    Topics: Analgesics, Opioid; Animals; Cornea; Corneal Opacity; Dose-Response Relationship, Drug; Male; Methadone; Methadyl Acetate; Morphine; Pupil; Rats

1980
Various factors which affect the rate of development of tolerance and physical dependence to abused drugs.
    NIDA research monograph, 1984, Volume: 54

    Topics: Animals; Body Weight; Drug Tolerance; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Reaction Time; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1984
Modification of drug effects by l-alpha-acetylmethadol.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:4

    Topics: Animals; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Methadone; Methadyl Acetate; Morphine; Pentobarbital; Phencyclidine; Rats; Rats, Inbred Strains

1984
Effects of levo-alpha-acetylmethadol (LAAM) on morphine self-administration in the rat.
    Psychopharmacology, 1981, Volume: 73, Issue:1

    Topics: Animals; Electroencephalography; Female; Methadone; Methadyl Acetate; Morphine; Rats; Self Administration; Sleep, REM

1981
Narcotic abstinence in dependent rats: EEG and behavioral correlates.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:1

    Topics: Animals; Behavior, Animal; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Sleep, REM; Substance Withdrawal Syndrome

1980
A method for determining cumulative behavioral toxicity after chronic oral administration of l-alpha-acetylmethadol to female rats.
    Neurobehavioral toxicology, 1980,Spring, Volume: 2, Issue:1

    Topics: Administration, Oral; Animals; Behavior, Animal; Drug Tolerance; Female; Fetus; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Substance-Related Disorders

1980
Effects of narcotic abstinence on schedule-controlled behavior in dependent rats.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:3

    Topics: Animals; Conditioning, Operant; Female; Humans; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Reinforcement Schedule; Substance Withdrawal Syndrome; Time Factors

1981
Morphine challenges in levo-alpha-acetylmethadol (LAAM) post-addict rats.
    Life sciences, 1981, Mar-30, Volume: 28, Issue:13

    Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Wakefulness

1981
Differential electroencephalographic and behavioral cross tolerance to morphine and methadone in the l-alpha-acetylmethadol (LAAM)-maintained rat.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:3

    Topics: Animals; Behavior, Animal; Drug Tolerance; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Rats, Inbred Strains

1982
Comparative study of the electroencephalographic and behavioral effects of l-alpha-acetylmethadol (LAAM), two of its metabolites and morphine and methadone in the rat.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:2

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electrocardiography; Female; Methadone; Methadyl Acetate; Morphine; Rats

1980
SIV mutations detected in morphine-treated Macaca mulatta following SIVmac239 infection.
    Advances in experimental medicine and biology, 1995, Volume: 373

    Topics: Amino Acid Sequence; Animals; Antigens, Viral; Base Sequence; Blotting, Western; Cell Line; Humans; Macaca mulatta; Male; Methadyl Acetate; Molecular Biology; Molecular Sequence Data; Morphine; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus

1995
Discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), buprenorphine and methadone in morphine-treated rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: Animals; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Naltrexone; Narcotic Antagonists; Narcotics

1997
l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2

    Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Substance Withdrawal Syndrome

1997
Relative efficacy of buprenorphine, nalbuphine and morphine in opioid-treated rhesus monkeys discriminating naltrexone.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:3

    Topics: Animals; Buprenorphine; Conditioning, Operant; Discrimination Learning; Female; Macaca mulatta; Male; Methadyl Acetate; Morphine; Nalbuphine; Naltrexone; Narcotics; Receptors, Opioid, mu

2003