methadone has been researched along with verapamil in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 9 (39.13) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Huang, JT; Takemori, AE | 1 |
| Lichtenwalner, MR; Mencken, T; Petosa, M; Tully, R | 1 |
| Khosropour, P; Tsay, YG | 1 |
| Barthe, L; Bouër, R; Houin, G; Philibert, C; Tournaire, C; Woodley, J | 1 |
| Greenblatt, DJ; Perloff, MD; Störmer, E; von Moltke, LL | 1 |
| Dagenais, C; Graff, CL; Pollack, GM | 1 |
| Ejsing, TB; Hasselstrøm, J; Linnet, K | 1 |
| Andrews, FM; Linardi, RL; Stokes, AM | 1 |
| Benjamin Guise, J; Bickel, W; Brooks Gentry, W; Cargile, C; Mancino, M; Oliveto, A; Sanders, N | 1 |
| Chiou, MH; Hsieh, YW; Huang, CL; Hung, CC; Lane, HY; Teng, YN | 1 |
| Alvarez-Baron, C; Guo, D; Randolph, AL; Ren, M; Sheng, J; Thiebaud, N; Tran, PN; Wu, WW; Zhao, J | 1 |
1 review(s) available for methadone and verapamil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for methadone and verapamil
| Article | Year |
|---|---|
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure.
Topics: Adult; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Self Report; Substance Withdrawal Syndrome; Verapamil | 2013 |
21 other study(ies) available for methadone and verapamil
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results | 2006 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
Accumulation of methadone by the choroid plexus in vitro.
Topics: Animals; Antimetabolites; Biological Transport; Calcium; Choroid Plexus; In Vitro Techniques; Magnesium; Male; Methadone; Morphine; Narcotic Antagonists; Phosphates; Rabbits; Time Factors; Verapamil | 1975 |
False-positive immunochemical screen for methadone attributable to metabolites of verapamil.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cross Reactions; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Methadone; Narcotics; Reagent Kits, Diagnostic; Substance Abuse Detection; Verapamil | 1998 |
Response to a report on false-positive results in a methadone enzyme immunoassay.
Topics: Calcium Channel Blockers; False Positive Reactions; Humans; Immunoenzyme Techniques; Methadone; Narcotics; Substance Abuse Detection; Verapamil | 1998 |
The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Intestinal Absorption; Intestine, Small; Male; Methadone; Narcotics; Permeability; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil | 1999 |
Methadone inhibits rhodamine123 transport in Caco-2 cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Drug Interactions; Humans; Methadone; Rhodamine 123; Verapamil | 2001 |
Variable modulation of opioid brain uptake by P-glycoprotein in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzomorphans; Biological Transport; Brain; Drug Interactions; Fentanyl; Loperamide; Meperidine; Methadone; Mice; Narcotics; Quinidine; Time Factors; Verapamil | 2004 |
The influence of P-glycoprotein on cerebral and hepatic concentrations of nortriptyline and its metabolites.
Topics: Adenosine Triphosphatases; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cyclosporine; Drug Interactions; Enzyme Inhibitors; Liver; Male; Methadone; Mice; Mice, Knockout; Nortriptyline; Rats; Rats, Wistar; Verapamil | 2006 |
The effect of P-glycoprotein on methadone hydrochloride flux in equine intestinal mucosa.
Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Horses; Intestinal Absorption; Intestinal Mucosa; Jejunum; Methadone; Rhodamine 123; Verapamil | 2013 |
Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone.
Topics: Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Fluoresceins; Genetic Variation; HEK293 Cells; Humans; Immunoblotting; Inhibitory Concentration 50; Kinetics; Methadone; Mutagenesis, Site-Directed; Real-Time Polymerase Chain Reaction; Rhodamine 123; Verapamil | 2013 |
Experimental factors that impact CaV1.2 channel pharmacology-Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the "step-step-ramp" voltage protocol.
Topics: Calcium Channels, L-Type; Excipients; Methadone; Reproducibility of Results; Temperature; Verapamil | 2022 |