methadone and verapamil

methadone has been researched along with verapamil in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.35)18.7374
1990's3 (13.04)18.2507
2000's9 (39.13)29.6817
2010's9 (39.13)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Nagashima, R; Nishikawa, T; Tobita, M1
Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Huang, JT; Takemori, AE1
Lichtenwalner, MR; Mencken, T; Petosa, M; Tully, R1
Khosropour, P; Tsay, YG1
Barthe, L; Bouër, R; Houin, G; Philibert, C; Tournaire, C; Woodley, J1
Greenblatt, DJ; Perloff, MD; Störmer, E; von Moltke, LL1
Dagenais, C; Graff, CL; Pollack, GM1
Ejsing, TB; Hasselstrøm, J; Linnet, K1
Andrews, FM; Linardi, RL; Stokes, AM1
Benjamin Guise, J; Bickel, W; Brooks Gentry, W; Cargile, C; Mancino, M; Oliveto, A; Sanders, N1
Chiou, MH; Hsieh, YW; Huang, CL; Hung, CC; Lane, HY; Teng, YN1
Alvarez-Baron, C; Guo, D; Randolph, AL; Ren, M; Sheng, J; Thiebaud, N; Tran, PN; Wu, WW; Zhao, J1

Reviews

1 review(s) available for methadone and verapamil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for methadone and verapamil

ArticleYear
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure.
    European journal of pharmacology, 2013, Sep-05, Volume: 715, Issue:1-3

    Topics: Adult; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Self Report; Substance Withdrawal Syndrome; Verapamil

2013

Other Studies

21 other study(ies) available for methadone and verapamil

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7

    Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results

2006
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5

    Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
Accumulation of methadone by the choroid plexus in vitro.
    Neuropharmacology, 1975, Volume: 14, Issue:3

    Topics: Animals; Antimetabolites; Biological Transport; Calcium; Choroid Plexus; In Vitro Techniques; Magnesium; Male; Methadone; Morphine; Narcotic Antagonists; Phosphates; Rabbits; Time Factors; Verapamil

1975
False-positive immunochemical screen for methadone attributable to metabolites of verapamil.
    Clinical chemistry, 1998, Volume: 44, Issue:5

    Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cross Reactions; False Positive Reactions; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Methadone; Narcotics; Reagent Kits, Diagnostic; Substance Abuse Detection; Verapamil

1998
Response to a report on false-positive results in a methadone enzyme immunoassay.
    Clinical chemistry, 1998, Volume: 44, Issue:10

    Topics: Calcium Channel Blockers; False Positive Reactions; Humans; Immunoenzyme Techniques; Methadone; Narcotics; Substance Abuse Detection; Verapamil

1998
The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:4

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Intestinal Absorption; Intestine, Small; Male; Methadone; Narcotics; Permeability; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil

1999
Methadone inhibits rhodamine123 transport in Caco-2 cells.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:7

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Drug Interactions; Humans; Methadone; Rhodamine 123; Verapamil

2001
Variable modulation of opioid brain uptake by P-glycoprotein in mice.
    Biochemical pharmacology, 2004, Jan-15, Volume: 67, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzomorphans; Biological Transport; Brain; Drug Interactions; Fentanyl; Loperamide; Meperidine; Methadone; Mice; Narcotics; Quinidine; Time Factors; Verapamil

2004
The influence of P-glycoprotein on cerebral and hepatic concentrations of nortriptyline and its metabolites.
    Drug metabolism and drug interactions, 2006, Volume: 21, Issue:3-4

    Topics: Adenosine Triphosphatases; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cyclosporine; Drug Interactions; Enzyme Inhibitors; Liver; Male; Methadone; Mice; Mice, Knockout; Nortriptyline; Rats; Rats, Wistar; Verapamil

2006
The effect of P-glycoprotein on methadone hydrochloride flux in equine intestinal mucosa.
    Journal of veterinary pharmacology and therapeutics, 2013, Volume: 36, Issue:1

    Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Horses; Intestinal Absorption; Intestinal Mucosa; Jejunum; Methadone; Rhodamine 123; Verapamil

2013
Functional impact of ABCB1 variants on interactions between P-glycoprotein and methadone.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Fluoresceins; Genetic Variation; HEK293 Cells; Humans; Immunoblotting; Inhibitory Concentration 50; Kinetics; Methadone; Mutagenesis, Site-Directed; Real-Time Polymerase Chain Reaction; Rhodamine 123; Verapamil

2013
Experimental factors that impact CaV1.2 channel pharmacology-Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the "step-step-ramp" voltage protocol.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Calcium Channels, L-Type; Excipients; Methadone; Reproducibility of Results; Temperature; Verapamil

2022