Compounds > methadone

methadone and u-50488

methadone has been researched along with u-50488 in 17 studies

Research

Studies (17)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (52.94)	18.7374
1990's	6 (35.29)	18.2507
2000's	1 (5.88)	29.6817
2010's	1 (5.88)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Craft, RM; Dykstra, LA	2
Negus, SS; Picker, MJ; Powell, KR	1
Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ	1
Dykstra, LA	1
Bronson, ME; Sparber, SB	1
Adler, MW; Furman, MB; Geller, EB; Lynch, TJ; Martinez, RP	1
Dykstra, LA; Massie, CA; Picker, M	1
Culpepper-Morgan, J; Holt, PR; Kreek, MJ; LaRoche, D; O'Bryan, L; Zhang, J	1
Dykstra, LA; Massie, CA	1
Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM	1
Dykstra, LA; Picker, M	1
Dykstra, LA; Heise, JW; Picker, M	1
Neil, A	1
Daenens, P; Tytgat, J; Ulens, C	1
Philibin, SD; Porter, JH; Vann, RE; Varvel, SA; Walentiny, DM; Wise, LE	1
Heller, NM; Maher, DP; Walia, D	1

Other Studies

17 other study(ies) available for methadone and u-50488

Article	Year
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination	1992
Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation. Psychopharmacology, 1991, Volume: 103, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Fentanyl; Food; Male; Methadone; Morphine; Naloxone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule	1991
Differential cross-tolerance to opioids in squirrel monkeys responding under a shock titration schedule. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cyclazocine; Drug Tolerance; Electroshock; Ethylketocyclazocine; Male; Methadone; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1990
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1990
Butorphanol, levallorphan, nalbuphine and nalorphine as antagonists in the squirrel monkey. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Butorphanol; Dose-Response Relationship, Drug; Levallorphan; Male; Methadone; Morphinans; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1990
Evidence of single dose opioid dependence in 12- to 14-day-old chicken embryos. Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chick Embryo; Methadone; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Receptors, Opioid; Substance Withdrawal Syndrome	1989
A new analysis of whole-body calorimetry data. NIDA research monograph, 1989, Volume: 95 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature Regulation; Brain; Calorimetry; Methadone; Morphine; Oxygen Consumption; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1989
Evaluation of the effects of opioid agonists and antagonists under a delayed matching-to-sample procedure in pigeons. Psychopharmacology, 1987, Volume: 93, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Columbidae; Cyclazocine; Discrimination Learning; Endorphins; Ethylketocyclazocine; Female; Methadone; Morphine; Naloxone; Phencyclidine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma	1987
Orally administered kappa as well as mu opiate agonists delay gastrointestinal transit time in the guinea pig. Life sciences, 1988, Volume: 42, Issue:21 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animals; Etorphine; Gastrointestinal Motility; Guinea Pigs; Male; Methadone; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1988
Antagonism of the analgesic effects of mu and kappa opioid agonists in the squirrel monkey. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Azocines; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1988
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu	1987
Comparison of the discriminative stimulus properties of U50,488 and morphine in pigeons. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Columbidae; Cyclazocine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Methadone; Morphine; Naloxone; Phenazocine; Phencyclidine; Pyrrolidines; Time Factors	1987
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats. Pharmacology, biochemistry, and behavior, 1987, Volume: 27, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule	1987
Affinities of some common opioid analgesics towards four binding sites in mouse brain. Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 328, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding Sites; Brain; Codeine; Cyclazocine; Dextropropoxyphene; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Methionine; Ethylketocyclazocine; In Vitro Techniques; Membranes; Methadone; Mice; Models, Biological; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu	1984
The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands. European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextropropoxyphene; DNA, Recombinant; Dose-Response Relationship, Drug; Electric Stimulation; Female; GTP-Binding Proteins; Ligands; Membrane Potentials; Methadone; Mice; Microinjections; Morphine; Naloxone; Oocytes; Patch-Clamp Techniques; Plasmids; Potassium Channels; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Complementary; Xenopus laevis	1999
Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle. Drug and alcohol dependence, 2009, Aug-01, Volume: 103, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Choice Behavior; Conditioning, Operant; Discrimination, Psychological; Heroin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Stereoisomerism	2009
Suppression of Human Natural Killer Cells by Different Classes of Opioids. Anesthesia and analgesia, 2019, Volume: 128, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol	2019