methadone and probenecid

methadone has been researched along with probenecid in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19909 (56.25)18.7374
1990's0 (0.00)18.2507
2000's4 (25.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Chang, TK; Ensom, MH; Kiang, TK1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Oka, T; Sawa, A1
Cramer, H; Goodwin, FK; Post, RM1
Ahtee, L; Carlsson, A1
Fuller, RW; Perry, KW1
Dunner, DL; Goodwin, FK; Gordon, EK; Post, RM1
Goodlet, I; Sugrue, MF1
Bowers, MB; Kleber, HD1
Bowers, MB; Davis, L; Kleber, HD1
Axelrod, J; Goodwin, FK; Tamarkin, NR1

Reviews

2 review(s) available for methadone and probenecid

ArticleYear
UDP-glucuronosyltransferases and clinical drug-drug interactions.
    Pharmacology & therapeutics, 2005, Volume: 106, Issue:1

    Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

14 other study(ies) available for methadone and probenecid

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Effects of narcotic analgesics on serotonin metabolism in brain of rats and mice.
    Japanese journal of pharmacology, 1976, Volume: 26, Issue:5

    Topics: Analgesics, Opioid; Animals; Atropine; Brain; Drug Interactions; Fenclonine; Hydroxyindoleacetic Acid; Male; Meperidine; Methadone; Mice; Mice, Inbred ICR; Morphine; Naloxone; Pargyline; Probenecid; Rats; Serotonin

1976
Cyclic AMP in cerebrospinal fluid of manic and depressive patients.
    Psychological medicine, 1977, Volume: 7, Issue:4

    Topics: Administration, Oral; Amitriptyline; Bipolar Disorder; Cyclic AMP; Depression; Humans; Imipramine; Lithium; Methadone; Methyltyrosines; Physical Exertion; Probenecid; Tryptophan

1977
Dual action of methadone on 5-HT synthesis and metabolism.
    Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 307, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Brain; Dihydroxyphenylalanine; Hydroxyindoleacetic Acid; Male; Methadone; Morphine; Naloxone; Probenecid; Rats; Serotonin; Tryptophan; Tyrosine

1979
Inability of methadone to prevent the depletion of brain 5-hydroxyindoles by p-chloroamphetamine.
    Biochemical pharmacology, 1976, Feb-01, Volume: 25, Issue:3

    Topics: Amphetamines; Animals; Brain; Depression, Chemical; Hydroxyindoleacetic Acid; Indoles; Male; Methadone; Mice; p-Chloroamphetamine; Probenecid; Rats

1976
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique.
    The American journal of psychiatry, 1973, Volume: 130, Issue:1

    Topics: Affective Symptoms; Biological Transport, Active; Bipolar Disorder; Brain; Brain Chemistry; Depression; Dopamine; Heroin Dependence; Humans; Hydroxyindoleacetic Acid; Methadone; Norepinephrine; Phenylacetates; Probenecid; Serotonin; Synaptic Transmission

1973
Effects of acutely administered analgesic drugs on rat brain 5-hydroxytryptamine turnover.
    British journal of pharmacology, 1972, Volume: 46, Issue:3

    Topics: Analgesics; Animals; Brain; Brain Chemistry; Hydroxyindoleacetic Acid; Male; Meperidine; Methadone; Morphine; Pargyline; Pentazocine; Probenecid; Rats; Serotonin

1972
Methadone increases mouse brain 5-hydroxyindoleacetic acid.
    Nature, 1971, Jan-08, Volume: 229, Issue:5280

    Topics: Animals; Brain; Hydroxyindoleacetic Acid; Methadone; Mice; Morphine; Pargyline; Probenecid; Serotonin; Stimulation, Chemical

1971
Acid monoamine metabolites in cerebrospinal fluid during methadone maintenance.
    Nature, 1971, Aug-20, Volume: 232, Issue:5312

    Topics: Adult; Female; Heroin; Humans; Hydroxyindoleacetic Acid; Male; Methadone; Middle Aged; Phenylacetates; Probenecid; Substance-Related Disorders

1971
Rapid elevation of biogenic amine metabolites in human CSF following probenecid.
    Life sciences. Pt. 1: Physiology and pharmacology, 1970, Dec-15, Volume: 9, Issue:24

    Topics: Administration, Oral; Affective Symptoms; Dihydroxyphenylalanine; Female; Headache; Humans; Hydroxyindoleacetic Acid; Male; Methadone; Nausea; Phenylacetates; Probenecid; Spinal Puncture; Vomiting

1970