methadone has been researched along with phenobarbital in 108 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 68 (62.96) | 18.7374 |
1990's | 7 (6.48) | 18.2507 |
2000's | 11 (10.19) | 29.6817 |
2010's | 15 (13.89) | 24.3611 |
2020's | 7 (6.48) | 2.80 |
Authors | Studies |
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Topliss, JG; Yoshida, F | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Liu, SJ; Wang, RI | 4 |
Cohen, SN; Neumann, LL | 1 |
Di Gregorio, GJ; Knaiz, EK; Nagle, BT; Piraino, AJ | 1 |
Ghodse, AH; Mack, JW; Reed, JL | 1 |
Evans, DB; Liu, SJ; Wang, RI | 3 |
Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K | 1 |
Franklin, MR; Roberts, SM | 1 |
Burdock, GA; Hackett, RB; Masten, LW | 1 |
Madden, JD | 1 |
Lefkowitz, SS; Nemeth, D | 1 |
Carlson, KR; Eibergen, RD | 2 |
Chappel, JN; Davis, R; Gumpel, J; Madden, JD; Mejia, A; Zuspan, F | 1 |
Bauer, J; Gerber, N; Gordon, P; Leger, RM; Lynn, RK; Smith, RG | 1 |
Hasegawa, AT; Roerig, DL; Wang, RI | 3 |
Burkhalter, A; Masten, LW; Peterson, GR; Way, EL | 1 |
Zelson, C | 2 |
Keith, LG; Pildes, RS; Vargas, GC; Vidyasagar, D | 1 |
Finnegan, LP; Kron, RE; Litt, M | 1 |
Greenstein, R; O'Brien, CP; Woody, GE | 1 |
Henderson, GL; Rosenkranz, RP | 1 |
Eng, D; Finnegan, LP; Kron, RE; Litt, M; Phoenix, MD | 1 |
Alexander, GJ | 1 |
Breimer, DD; de Boer, AG; van Hoogdalem, E | 1 |
Kattner, E | 1 |
Calvert, R; Feely, M; Hay, A; Raistrick, D; Wolff, K | 1 |
Hinderliter, SA; Sutton, LR | 1 |
Burke, WM; Dhopesh, V; Maany, I; Ravi, NV; Woody, GE | 1 |
Buckley, PF; Charlton, EJ; Sizemore, WA | 1 |
Calzolari, S; Fundaro, C; Mariotti, P; Steffanini, MC; Tempesta, E; Torriolo, MG | 1 |
Onofrj, M; Pinto, F; Pola, P; Tempesta, E; Torrioli, MG | 1 |
Calabrese, JR; Gulledge, AD | 1 |
Kuttab, SH; Nowshad, F; Shargel, L | 1 |
Bailey, DN; Jatlow, PI | 1 |
Kettner, VR; Lerner, SE; Smith, DE; Wesson, DR | 1 |
Julich, H | 1 |
Harper, RG; Panepinto, WC; Purow, HM; Sang, E; Solish, GI | 1 |
Blatman, S; Lipsitz, PJ | 1 |
Kaneto, H; Koida, M; Nakanishi, H; Sasano, H | 1 |
Blatman, S | 1 |
Baselt, RC; Casarett, LJ | 1 |
Frings, CS; Queen, CA | 1 |
Pert, CB; Snyder, SH | 1 |
Choulis, NH | 1 |
Blenman, S; Harper, RG; Sia, CG | 1 |
Gartner, LM; Kandall, SR | 1 |
Grunberg, E; Klein, B; Sheehan, JE | 1 |
Glass, L | 1 |
Gould, JB; Rothstein, P | 1 |
Alvares, AP; Kappas, A | 1 |
Bastos, ML; Chedekel, M; Jukofsky, D; Mulé, SJ; Saffer, E | 1 |
Evans, HE; Glass, L | 1 |
Harper, RG; Reddy, AM; Stern, G | 1 |
Molinengo, L; Ricci-Gamalero, S | 1 |
Pálosi, E; Szporny, L | 1 |
Novick, DM | 1 |
Carin, I; Glass, L; Parekh, A; Solomon, N; Steigman, J; Wong, S | 1 |
Freeman, RW; Harbison, RD; James, RC | 1 |
Carlson, RK; Little, TL; Tielke, VM | 1 |
Bellward, GD; Gontovnick, LS | 1 |
Deshpande, JK; Gregory, DF; Tobias, JD | 1 |
Ikizler, Y; Koren, G; Selby, P; Theis, JG | 1 |
Coyle, MG; Ferguson, A; Lagasse, L; Lester, B; Oh, W | 1 |
JACOBSEN, FG; SCHAFII-LASCHTENESCHAI, AH; ZETLER, G | 1 |
COLLINS, RJ; MACGREGOR, DW; WEEKS, JR | 1 |
BERGER, H | 1 |
KRUG, DC; PATRICK, SW; ROSENTHAL, T | 1 |
Coyle, MG; Ferguson, A; Lagasse, L; Lester, B; Liu, J | 1 |
Donn, SM; Sarkar, S | 1 |
Clement-de Boers, A; de Vries, MC; Leeuwenburgh-Pronk, WG | 1 |
Baewert, A; Ebner, N; Fischer, G; Jagsch, R; Peternell, A; Rohrmeister, K; Thau, K; Winklbaur, B | 1 |
Cheung, KL; Ho, JK; Hon, KL; Hung, EC; Ng, PC | 1 |
Ebner, N; Fischer, G; Jung, E; Kopf, N; Thau, K; Winklbaur, B | 1 |
Cordero, L; Gardner, DK; Lim, S; Prasad, MR; Samuels, P | 1 |
Bastanier, C; Beske, F; Esmaeili, A; Keinhorst, AK; Schlösser, R; Schuster, T | 1 |
Bio, LL; Poon, CY; Siu, A | 1 |
Becter, ML; Ewald, MB; George, M; Kitzmiller, JP; O'Donell, KA; Salhanick, S | 1 |
Crowley, M; Grow, JL; Hall, ES; Jasin, LR; Klebanoff, MA; McClead, RE; Meinzen-Derr, J; Mohan, VK; Stein, H; Walsh, MC; Wexelblatt, SL | 1 |
Calpena, AC; Clares, B; Mallandrich, M; Provenza, N; Pueyo, B | 1 |
McPherson, C | 1 |
Bührer, C; Hüseman, D; Mücke, S; Nagel, M; Siedentopf, J | 1 |
Bidegain, M; Cotten, CM; Edwards, LE; Hornik, CD; Hutchison, LB; Smith, PB | 1 |
Cooper, WO; Dudley, J; Maalouf, FI; Patrick, SW; Slaughter, JC | 1 |
Jones, HE; Kraft, WK | 1 |
MacMillan, KDL | 1 |
Bogen, DL; Czynski, AJ; Dansereau, LM; Davis, JM; Engelhardt, B; Hudak, ML; Lester, BM; Marro, P; Oliveira, EL; Shenberger, J; Wachman, EM | 1 |
Evrard, CA; Haas, DM; Haneline, LS; Jones, DR; Masters, AR; Metzger, IF; Quinney, SK; Thomas, AE | 1 |
Rosenberg, LB | 1 |
Brusseau, C; Burnette, T; Heidel, RE | 1 |
Adeniyi-Jones, S; Aghai, ZH; Boelig, RC; Carola, D; Greenspan, JS; Kraft, WK; Lafferty, M; Smith, J | 1 |
Davey, JG; Martin, J; Osborn, DA; Zankl, A | 1 |
Calcaterra, S; Kulick, B; Ray, L; Terasaki, D | 1 |
15 review(s) available for methadone and phenobarbital
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The neonatal narcotic withdrawal syndrome: a therapeutic challenge.
Topics: Barbiturates; Chlorpromazine; Diazepam; Humans; Infant Care; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opium; Phenobarbital; Sleep, REM; Substance Withdrawal Syndrome; Sucking Behavior | 1975 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Maternal-Fetal Exchange; Menstruation; Methadone; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome | 1977 |
Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs.
Topics: Administration, Rectal; Antiemetics; Atropine; Carbamazepine; Clonazepam; Delayed-Action Preparations; Diazepam; Flunitrazepam; Humans; Hydromorphone; Intestinal Absorption; Methadone; Methohexital; Midazolam; Morphine; Pharmacokinetics; Phenobarbital; Valproic Acid | 1991 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Infant, Newborn; Infant, Premature; Methadone; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Pregnancy Complications; Respiratory Insufficiency | 1991 |
The neonatal narcotic abstinence syndrome: a brief review.
Topics: Chlorpromazine; Diazepam; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opium; Phenobarbital; Substance Withdrawal Syndrome | 1985 |
Narcotic poisoning of children (1) through accidental ingestion of methadone and (2) in utero.
Topics: Administration, Oral; Apgar Score; Birth Weight; Child; Child Care; Female; Gestational Age; Heroin Dependence; Humans; Infant, Newborn; Levallorphan; Maternal-Fetal Exchange; Methadone; Nalorphine; Naloxone; Phenobarbital; Poisoning; Pregnancy; Substance Withdrawal Syndrome; Tablets | 1974 |
Major medical problems and detoxification treatment of parenteral drug-abusing alcoholics.
Topics: Acquired Immunodeficiency Syndrome; Alcoholism; Homosexuality; Humans; Hypnotics and Sedatives; Infections; Injections, Intravenous; Liver Diseases, Alcoholic; Male; Methadone; Methicillin; Opioid-Related Disorders; Penicillin Resistance; Phenobarbital; Staphylococcus aureus; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Current management of the neonatal abstinence syndrome: a critical analysis of the evidence.
Topics: Analgesics, Opioid; Anticonvulsants; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Clonidine; Diazepam; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; MEDLINE; Methadone; Morphine; Neonatal Abstinence Syndrome; Opium; Parasympatholytics; Phenobarbital; Sympatholytics | 1997 |
Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates.
Topics: Buprenorphine; Diagnosis, Dual (Psychiatry); Female; GABA Modulators; Humans; Infant, Newborn; Mental Disorders; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Pregnancy; Pregnancy Complications | 2008 |
Update on the pharmacologic management of neonatal abstinence syndrome.
Topics: Benzodiazepines; Buprenorphine; Clonidine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy | 2011 |
Pharmacotherapy for Neonatal Abstinence Syndrome: Choosing the Right Opioid or No Opioid at All.
Topics: Analgesics; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Phenobarbital | 2016 |
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome.
Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Breast Feeding; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Clonidine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Kangaroo-Mother Care Method; Maternal-Fetal Exchange; Methadone; Neonatal Abstinence Syndrome; Occupational Therapy; Opiate Substitution Treatment; Opioid-Related Disorders; Pain Management; Patient Education as Topic; Phenobarbital; Physical Therapy Modalities; Pregnancy; Pregnancy Complications; Rooming-in Care | 2019 |
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Intensive Care Units, Neonatal; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Nurseries, Hospital; Opiate Substitution Treatment; Opioid-Related Disorders; Parents; Phenobarbital; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rooming-in Care; Severity of Illness Index; Treatment Outcome | 2019 |
Opioid treatment for opioid withdrawal in newborn infants.
Topics: Buprenorphine; Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Opium; Phenobarbital; Randomized Controlled Trials as Topic | 2021 |
6 trial(s) available for methadone and phenobarbital
Article | Year |
---|---|
Measuring compliance in methadone maintenance patients: use of a pharmacologic indicator to "estimate" methadone plasma levels.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Illicit Drugs; Methadone; Middle Aged; Opioid-Related Disorders; Patient Compliance; Phenobarbital; Treatment Refusal | 1991 |
Neonatal methadone withdrawal. Effect of two treatment regimens.
Topics: Blood Pressure; Carbon Dioxide; Drug Administration Schedule; Female; Humans; Hydrogen-Ion Concentration; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Opium; Phenobarbital; Pregnancy; Random Allocation; Respiration; Substance Withdrawal Syndrome; Thyroxine; Time Factors | 1983 |
Diluted tincture of opium (DTO) and phenobarbital versus DTO alone for neonatal opiate withdrawal in term infants.
Topics: Analgesics, Opioid; Drug Therapy, Combination; Heroin; Hospital Costs; Humans; Hypnotics and Sedatives; Infant, Newborn; Length of Stay; Methadone; Neonatal Abstinence Syndrome; Opium; Phenobarbital; Statistics, Nonparametric | 2002 |
Neurobehavioral effects of treatment for opiate withdrawal.
Topics: Analgesics, Opioid; Drug Therapy, Combination; Heroin; Humans; Hypnotics and Sedatives; Infant Behavior; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opium; Phenobarbital; Psychomotor Performance; Treatment Outcome | 2005 |
Management of neonatal abstinence syndrome in neonates born to opioid maintained women.
Topics: Adult; Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Patient Selection; Phenobarbital; Pregnancy; Pregnancy Complications | 2007 |
Neurodevelopmental Outcomes of Neonates Randomized to Morphine or Methadone for Treatment of Neonatal Abstinence Syndrome.
Topics: Female; Humans; Infant; Infant, Newborn; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Nervous System; Phenobarbital | 2020 |
87 other study(ies) available for methadone and phenobarbital
Article | Year |
---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Further study on the correlation of urinary excretion of a methadone metabolite with methadone metabolism and analgesia in the rat.
Topics: Analgesics; Animals; Dealkylation; Male; Methadone; Phenobarbital; Rats; Time Factors | 1979 |
Secretion of drugs by the parotid glands of rats and human beings.
Topics: Acetylcholine; Adult; Amobarbital; Animals; Barbiturates; Chlorpromazine; Codeine; Glutethimide; Humans; Male; Meprobamate; Methadone; Morphine; Narcotics; Parotid Gland; Pentobarbital; Phenobarbital; Pilocarpine; Rats; Saliva; Secobarbital; Tranquilizing Agents | 1977 |
Analysis and differentiation of mechanism of tolerance to methadone in methadone-fed rats.
Topics: Analgesia; Animals; Drug Tolerance; Male; Methadone; Morphine; Phenobarbital; Rats; Tissue Distribution | 1979 |
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Morphine Dependence; Phenobarbital; Platelet Aggregation; Substance Withdrawal Syndrome; Substance-Related Disorders; Thrombocytosis | 1979 |
Modification of hepatic microsomal oxidative drug metabolism in rats by the opiate maintenance drugs acetylmethadol, propoxyphene, and methadone.
Topics: Animals; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Male; Methadone; Methadyl Acetate; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship | 1979 |
Comparison of hepatic microsomal enzyme induction by methadone, phenobarbital and 3-methylcholanthrene in the mouse.
Topics: Animals; Enzyme Induction; In Vitro Techniques; Male; Methadone; Methylcholanthrene; Mice; Mice, Inbred ICR; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Sleep | 1979 |
Correlation of urinary excretion of methadone metabolites with methadone metabolism and analgesia in the rat.
Topics: Analgesics; Animals; Biotransformation; Desipramine; Diazepam; Drug Interactions; Male; Methadone; Phenobarbital; Rats; Reaction Time; Time Factors; Tissue Distribution | 1978 |
Problems pertaining to the care of newborn infants of drug-addicted women.
Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Substance-Related Disorders; Sucking Behavior; Tremor | 1978 |
Determination of urinary excretion of a methadone metabolite as an indirect measurement of methadone metabolism in the rat.
Topics: Animals; Desipramine; Liver; Male; Methadone; Phenobarbital; Rats; Time Factors | 1978 |
Immunosuppression of rosette-forming cells.
Topics: Amphetamine; Animals; Body Weight; Caffeine; Erythrocytes; Humans; Immunity; Immunologic Techniques; Immunosuppression Therapy; Leukocytes; Male; Methadone; Mice; Morphine; Organ Size; Pentobarbital; Phenobarbital; Sheep; Spleen; Substance-Related Disorders | 1976 |
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior | 1976 |
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors | 1976 |
Observation and treatment of neonatal narcotic withdrawal.
Topics: Diazepam; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Phenobarbital; Pregnancy; Substance Withdrawal Syndrome | 1977 |
The metabolism of d-, l- and dl-methadone in the isolated perfused rat liver.
Topics: Animals; Biotransformation; Half-Life; Isomerism; Liver; Methadone; Perfusion; Phenobarbital; Proadifen; Rats | 1977 |
Effect of alteration of metabolism on the analgesic activity, toxicity, distribution and excretion of l-alpha-acetylmethadol in the rat.
Topics: Analgesics; Animals; Bile; Feces; Lethal Dose 50; Liver; Male; Methadone; Methadyl Acetate; Phenobarbital; Rats; Tissue Distribution | 1977 |
Role of metabolism in the biliary excretion of methadone metabolites.
Topics: Animals; Bile; Isotope Labeling; Male; Methadone; Phenobarbital; Pyrrolidines; Rats; Time Factors | 1976 |
Microsomal enzyme induction by methadone and its implications on tolerance to methodone lethality.
Topics: Animals; Biotransformation; Drug Tolerance; Enzyme Induction; Lethal Dose 50; Liver; Methadone; Mice; Microsomes, Liver; Morphine; Organ Size; Oxidoreductases, N-Demethylating; Phenobarbital; Proteins | 1975 |
Effect of phenobarbital pretreatment on the metabolism and biliary excretion of methadone.
Topics: Animals; Bile; Dealkylation; Glucuronates; Male; Methadone; Microsomes, Liver; Phenobarbital; Rats; Time Factors | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Phenobarbital; Pregnancy; Pregnancy Complications; Seizures; Sleep Wake Disorders; Substance Withdrawal Syndrome; Vomiting; Water-Electrolyte Balance | 1975 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalometry; Chlorpromazine; Female; Hematocrit; Hemorrhage; Heroin Dependence; Humans; Hyaline Membrane Disease; Infant, Newborn; Infant, Newborn, Diseases; Jaundice, Neonatal; Male; Maternal-Fetal Exchange; Methadone; Phenobarbital; Pregnancy; Respiratory Distress Syndrome, Newborn; Substance Withdrawal Syndrome | 1975 |
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opium; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Substance-Related Disorders; Sucking Behavior | 1975 |
Misuse and abuse of diazepam: an increasingly common medical problem.
Topics: Adult; Diazepam; Drug Prescriptions; Heroin Dependence; Humans; Legislation, Drug; Male; Methadone; Phenobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1975 |
Renal toxicity of l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Animals; Hematuria; Kidney Diseases; Kidney Tubules; Methadone; Methadyl Acetate; Morphine; Naloxone; Nephrosis; Phenobarbital; Rats; Time Factors | 1975 |
Increased analgesia and alterations in distribution and metabolism of methadone by desipramine in the rat.
Topics: Analgesia; Animals; Brain; Desipramine; Drug Synergism; In Vitro Techniques; Kidney; Lethal Dose 50; Liver; Lung; Male; Methadone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Reaction Time; Time Factors | 1975 |
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Sucking Behavior | 1976 |
Direct use of ion-exchange papers in hemagglutination-inhibition tests for drug abuse.
Topics: Aspirin; Chlorpromazine; Chromatography, Ion Exchange; Chromatography, Paper; Codeine; Hemagglutination Inhibition Tests; Humans; Methadone; Morphine; Nicotine; Phenobarbital; Substance-Related Disorders | 1976 |
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Parasympatholytics; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1990 |
Detoxification with phenobarbital of alprazolam-dependent polysubstance abusers.
Topics: Adult; Alprazolam; Combined Modality Therapy; Follow-Up Studies; Humans; Illicit Drugs; Male; Methadone; Opioid-Related Disorders; Phenobarbital; Substance-Related Disorders | 1990 |
Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol.
Topics: Analgesics, Opioid; Chronic Disease; Drug Combinations; Humans; Hypnotics and Sedatives; Methadone; Pain; Phenobarbital; Retrospective Studies; Substance Withdrawal Syndrome; Substance-Related Disorders; Therapeutic Equivalency | 1986 |
The influence of pharmacotherapy on the neonatal sleep patterns of infants born to opiate-addicted mothers.
Topics: Drug Therapy, Combination; Female; Humans; Infant, Newborn; Male; Methadone; Narcotics; Neonatal Abstinence Syndrome; Phenobarbital; Sleep | 1987 |
Fetal addiction to methadone: postnatal abstinence syndrome and development of visual evoked potentials.
Topics: Animals; Electroencephalography; Evoked Potentials, Visual; Female; Maternal-Fetal Exchange; Methadone; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1986 |
Effect of phenobarbital pretreatment on the plasma and urinary levels of (-)-alpha-acetylmethadol and its metabolites.
Topics: Animals; Biotransformation; Chromatography, Thin Layer; Injections, Intraperitoneal; Male; Methadone; Methadyl Acetate; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Methaqualone overdose: analytical methodology, and the significance of serum drug concentrations.
Topics: Alcohol Drinking; Alkanes; Chloroform; Chromatography, Gas; Chromatography, Thin Layer; Consciousness; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Histamine H1 Antagonists; Humans; Methadone; Methaqualone; Phenobarbital; Salicylamides; Scopolamine; Solubility; Spectrophotometry, Ultraviolet; Substance-Related Disorders | 1973 |
Treatment of polydrug users in San Francisco.
Topics: Adult; Aftercare; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; California; Crisis Intervention; Female; Financing, Government; Heroin Dependence; Hospitalization; Humans; Male; Methadone; MMPI; Phenobarbital; Psychotherapy; Substance-Related Disorders; Therapeutic Community | 1974 |
Infant of the addicted mother.
Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Phenobarbital; Pregnancy; Pregnancy Complications; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders | 1973 |
[Further studies on the effect of various drugs on the respiration].
Topics: Antifibrinolytic Agents; Benzoates; Central Nervous System Stimulants; Chlorpromazine; Humans; Meperidine; Methadone; Phenobarbital; Pulmonary Heart Disease; Respiration; Theobromine | 1968 |
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Male; Maternal-Fetal Exchange; Methadone; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome | 1974 |
Newborn infants of mothers on methadone maintenance.
Topics: Body Weight; Camphor; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Parents; Phenobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders | 1974 |
A scoring system for abstinence syndrome in morphine dependent mice and application to evaluate morphine type dependence liability of drugs.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Humans; Male; Meperidine; Methadone; Mice; Morphine Dependence; Phenobarbital; Substance Withdrawal Syndrome; Time Factors | 1973 |
Biliary and urinary elimination of methadone and its metabolites in the rat.
Topics: Administration, Oral; Animals; Bile; Chromatography, Gas; Chromatography, Thin Layer; Injections, Intravenous; Injections, Subcutaneous; Kinetics; Male; Methadone; Phenobarbital; Pyrrolidines; Rats; Time Factors; Tritium | 1972 |
Stability of certain drugs of abuse in urine specimens.
Topics: Amphetamine; Azides; Cocaine; Codeine; Drug Stability; Humans; Methadone; Morphine; Pharmaceutical Preparations; Phenobarbital; Secobarbital; Substance-Related Disorders; Temperature | 1972 |
Opiate receptor: demonstration in nervous tissue.
Topics: Analgesics; Animals; Atropine; Binding, Competitive; Brain; Carbachol; Codeine; Colchicine; Dextromethorphan; Dextropropoxyphene; Guinea Pigs; Histamine; Intestinal Mucosa; Levallorphan; Methadone; Mice; Morphine; Nalorphine; Naloxone; Phenazocine; Phenobarbital; Rats; Receptors, Drug; Serotonin; Tritium | 1973 |
Treatment of neonatal withdrawal syndrome.
Topics: Chlorpromazine; Diazepam; Heroin Dependence; Humans; Infant, Newborn; Methadone; Opium; Phenobarbital; Substance Withdrawal Syndrome | 1973 |
Separation and quantitation of mixtures of the most commonly abused drugs.
Topics: Amobarbital; Cannabis; Chromatography, Thin Layer; Dextroamphetamine; Ephedrine; Humans; Indicators and Reagents; Lysergic Acid Diethylamide; Methadone; Methamphetamine; Methods; Morphine; Opium; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Secobarbital; Solvents; Spectrophotometry, Ultraviolet; Substance-Related Disorders | 1973 |
Observations on the sudden death of infants born to addicted mothers.
Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Methadone; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; United States | 1973 |
Late presentation of drug withdrawal symptoms in newborns.
Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Opium; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Substance-Related Disorders | 1974 |
Use of fluorescamine ("Fluram") to detect amphetamine in urine by thin-layer chromatography.
Topics: Amphetamine; Benzofurans; Chromatography, Ion Exchange; Chromatography, Thin Layer; Drug Stability; Evaluation Studies as Topic; Fluorescence; Glutethimide; Humans; Indicators and Reagents; Methadone; Methamphetamine; Methods; Microchemistry; Morphine; Pentobarbital; Phenobarbital; Phenothiazines; Quinine; Spiro Compounds; Substance-Related Disorders; Time Factors | 1974 |
Narcotic withdrawal in the newborn infant.
Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Opium; Phenobarbital; Pregnancy; Pregnancy Complications; Prenatal Care; Substance Withdrawal Syndrome; Substance-Related Disorders | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Diazepam; Female; Fetus; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal Age; Methadone; Opium; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Substance-Related Disorders | 1974 |
Influence of phenobarbital on the metabolism and analgesic effect of methadone in rats.
Topics: Analgesia; Animals; Biotransformation; Estradiol; Hexobarbital; Hydrocarbons; Kinetics; Male; Methadone; Microsomes, Liver; Morphinans; Phenobarbital; Rats; Testosterone | 1972 |
Modifications of the XAD-2 resin column method for the extraction of drugs of abuse from human urine.
Topics: Amphetamine; Carbon Isotopes; Humans; Ion Exchange Resins; Methadone; Morphine; Phenobarbital; Tritium | 1972 |
Narcotic withdrawal in the newborn.
Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Phenobarbital; Pregnancy; Prognosis; Substance Withdrawal Syndrome; Substance-Related Disorders | 1972 |
Observations on heroin and methadone withdrawal in the newborn.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Neurologic Manifestations; Opium; Phenobarbital; Pregnancy; Pregnancy Complications; Substance Withdrawal Syndrome; Substance-Related Disorders; Vomiting | 1971 |
The "staircase maze" and the "simple staircase" in the analysis of the psychopharmacological action of CNS depressants.
Topics: Analgesics; Animals; Barbiturates; Behavior, Animal; Central Nervous System; Chlorpromazine; Hydroxyzine; Hypnotics and Sedatives; Meperidine; Methadone; Morphine; Paraldehyde; Pentobarbital; Phenobarbital; Rats; Reserpine; Tranquilizing Agents | 1970 |
New, simple method for the informative investigation of sedatives.
Topics: Amphetamine; Animals; Chlordiazepoxide; Chlorpromazine; Diazepam; Escape Reaction; Glutethimide; Haloperidol; Hypnotics and Sedatives; Imipramine; Male; Meprobamate; Methadone; Methods; Mice; Morphine; Nialamide; Pentobarbital; Phenobarbital; Reserpine; Tubocurarine; Urethane | 1967 |
Relationship of plasma level and pharmacological activity of methadone.
Topics: Animals; Biotransformation; Brain; Dose-Response Relationship, Drug; Humans; Metabolic Clearance Rate; Methadone; Nociceptors; Opioid-Related Disorders; Phenobarbital; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1984 |
Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome.
Topics: Adult; Biotransformation; Female; Heroin Dependence; Humans; Male; Methadone; Phenobarbital; Substance Withdrawal Syndrome | 1984 |
L-alpha-acetylmethadol-induced tissue alterations in mice.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Glutathione; Kidney; Liver; Male; Methadone; Methadyl Acetate; Methylcholanthrene; Mice; Mice, Inbred ICR; Necrosis; Phenobarbital; Time Factors | 1984 |
Stability of methadone pain cocktails.
Topics: Amitriptyline; Drug Combinations; Drug Stability; Hydroxyzine; Methadone; Phenobarbital | 1982 |
Sex and age dependence of the "selective" induction of rat hepatic microsomal epoxide hydratase following trans-stilbene oxide, l-alpha-acetylmethadol, or phenobarbital treatment.
Topics: Age Factors; Animals; Benzopyrene Hydroxylase; Enzyme Induction; Epoxide Hydrolases; Female; Male; Methadone; Methadyl Acetate; Microsomes, Liver; Phenobarbital; Rats; Sex Factors; Stilbenes | 1980 |
Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit.
Topics: Child; Female; Fentanyl; Humans; Iatrogenic Disease; Infant; Lorazepam; Male; Methadone; Midazolam; Phenobarbital; Substance Withdrawal Syndrome; Substance-Related Disorders | 1994 |
[THE INHIBITION OF MORPHINE, LEVORPHAN, METHADONE AND PETHIDINE ANALGESIA IN MICE BY "SPECIFIC" AND "NONSPECIFIC" ANTAGONISTS].
Topics: Analgesia; Animals; Atropine; Levorphanol; Meperidine; Mephenesin; Meprobamate; Methadone; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pain Management; Peptides; Phenobarbital; Research; Reserpine; Tissue Extracts | 1963 |
AN ATTEMPT TO DEMONSTRATE CEILING EFFICACY OF ANALGESICS IN RATS.
Topics: Aminopyrine; Amphetamine; Amphetamines; Analgesics; Aspirin; Barbiturates; Chlordiazepoxide; Chlorpromazine; Codeine; Dextropropoxyphene; Diphenhydramine; Meperidine; Meprobamate; Methadone; Morphine; Pharmacology; Phenobarbital; Rats; Rectum; Research; Toxicology | 1964 |
TREATMENT OF NARCOTIC ADDICTS IN PRIVATE PRACTICE.
Topics: Chlordiazepoxide; Chlorpromazine; Drug Therapy; Family Practice; General Practice; Glucose; Hospitalization; Humans; Hyaluronoglucosaminidase; Isotonic Solutions; Meprobamate; Methadone; Motivation; Narcotics; Pentobarbital; Phenobarbital; Private Practice; Promazine; Rehabilitation; Substance-Related Disorders | 1964 |
CONGENITAL NEONATAL NARCOTICS ADDICTION: A NATURAL HISTORY.
Topics: Chlorpromazine; Female; Humans; Maternal-Fetal Exchange; Meperidine; Methadone; Morphine Dependence; Mortality; Narcotics; Opioid-Related Disorders; Opium; Phenobarbital; Pregnancy; Psychotherapy; Social Conditions; Substance-Related Disorders | 1964 |
Management of neonatal abstinence syndrome in neonatal intensive care units: a national survey.
Topics: Humans; Hypnotics and Sedatives; Infant, Newborn; Injections, Intravenous; Intensive Care Units, Neonatal; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Psychomotor Performance; Surveys and Questionnaires; Treatment Outcome | 2006 |
[A multidisciplinary approach is necessary in the neonatal withdrawal syndrome].
Topics: Adult; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Male; Methadone; Narcotics; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Risk Factors; Treatment Outcome | 2006 |
Poisoning necessitating pediatric ICU admissions: size of pupils does matter.
Topics: Central Nervous System Depressants; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Infant, Newborn; Intensive Care Units, Pediatric; Male; Methadone; Neuromuscular Depolarizing Agents; Patient Admission; Phenobarbital; Pupil | 2008 |
High-dose methadone in pregnant women and its effect on duration of neonatal abstinence syndrome.
Topics: Adult; Anticonvulsants; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Pregnancy Outcome; Regression Analysis; Retrospective Studies | 2009 |
Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate.
Topics: Blood Pressure; Chloral Hydrate; Clonidine; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Retrospective Studies; Treatment Outcome | 2010 |
Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
Topics: Cytochrome P-450 CYP3A; Drug Overdose; Humans; Infant, Newborn; Intensive Care Units; Male; Methadone; Phenobarbital; Pyrrolidines | 2012 |
A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome.
Topics: Adult; Clinical Protocols; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intention to Treat Analysis; Length of Stay; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Phenobarbital; Treatment Outcome; Young Adult | 2014 |
Design of pediatric oral formulations with a low proportion of methadone or phenobarbital for the treatment of neonatal abstinence syndrome.
Topics: Administration, Oral; Chemistry, Pharmaceutical; Drug Design; Drug Packaging; Drug Stability; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Phenobarbital; Rheology; Treatment Outcome | 2016 |
Neonatal Abstinence Syndrome: Twelve Years of Experience at a Regional Referral Center.
Topics: Buprenorphine; Diseases in Twins; Female; Hospitalization; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Pregnancy; Referral and Consultation; Retrospective Studies; Substance Abuse Treatment Centers; Treatment Outcome | 2017 |
A case of infant delirium in the neonatal intensive care unit.
Topics: Amines; Analgesics, Opioid; Anti-Anxiety Agents; Cardiac Catheterization; Cyclohexanecarboxylic Acids; Delirium; Deprescriptions; Dexmedetomidine; Diazepam; Female; Fentanyl; Gabapentin; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Methadone; Midazolam; Phenobarbital; Postoperative Complications; Pregnancy; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Risperidone | 2017 |
Outpatient Pharmacotherapy for Neonatal Abstinence Syndrome.
Topics: Ambulatory Care; Analgesics, Opioid; Drug Therapy, Combination; Emergency Service, Hospital; Facilities and Services Utilization; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; Infant, Newborn; Length of Stay; Male; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Patient Readmission; Phenobarbital; Retrospective Studies; Treatment Outcome | 2018 |
Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Anticonvulsants; Dried Blood Spot Testing; Female; Humans; Infant, Newborn; Labor, Obstetric; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Pyrrolidines | 2021 |
What Are Two Days Worth? Facing Dilemmas Together at the End of Life.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Humans; Hypnotics and Sedatives; Informed Consent; Male; Methadone; Palliative Care; Pelvic Neoplasms; Phenobarbital; Quality of Life; Sarcoma; Terminal Care | 2020 |
Clonidine versus phenobarbital as adjunctive therapy for neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Clonidine; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Prospective Studies | 2020 |
Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome?
Topics: Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Pregnancy; Retrospective Studies | 2022 |
Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.
Topics: Alcoholism; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opioid Epidemic; Opioid-Related Disorders; Phenobarbital; Substance Withdrawal Syndrome | 2023 |