methadone has been researched along with naloxone in 537 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 273 (50.84) | 18.7374 |
| 1990's | 60 (11.17) | 18.2507 |
| 2000's | 77 (14.34) | 29.6817 |
| 2010's | 97 (18.06) | 24.3611 |
| 2020's | 30 (5.59) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Bodinier, MC; Bonnet, B; Chapelain, B; Déprez, B; Eckhoff, C; Horvath, D; Poulain, R | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Davis, DC; Holtzman, SG; Shannon, HE | 1 |
| Geller, I; Hartmann, RJ | 1 |
| Oka, T; Sawa, A | 1 |
| Berkowitz, BA | 1 |
| Chi, CH; Dixit, BN | 1 |
| Dykstra, LA; McMillan, DE | 1 |
| Maykut, MO | 1 |
| Segal, DS | 1 |
| Browne, RG; Derrington, DC; Segal, DS | 1 |
| Herndon, BL; Ringle, DA | 1 |
| Resnick, RB; Volavka, J | 1 |
| Horng, JS; Smits, SE; Wong, DT | 1 |
| Baskerville, JC; Brands, B; Gowdey, CW; Hirst, M | 1 |
| Ling, W | 1 |
| Extein, I; Gold, MS; Kleber, HD; Pottash, AL; Redmond, DE | 1 |
| Bergmann, F; Chaimovitz, M; Pasternak, V | 1 |
| Oka, T | 1 |
| Hrdina, PD; Ling, GM; Merali, Z; Singhal, RL | 1 |
| Altman, JL; Meyer, RE; Mirin, SM | 1 |
| Dewey, WL; Forbes, JE | 1 |
| Creese, I; Feinberg, AP; Snyder, SH | 1 |
| Terenius, L | 3 |
| Wikler, A | 2 |
| Cho, TM; Law, PY; Loh, HH; Ostwald, T; Way, EL | 1 |
| Ho, TK; LaBella, FS; Pinsky, C | 1 |
| Griffith, JD; Jasinski, DR; Pevnick, JS | 1 |
| Cameron, IL; Sheridan, PJ; Smith, NR | 1 |
| Byck, R; Gold, MS | 1 |
| Greenstein, R; O'Brien, CP; Woody, GE | 1 |
| Kestenbaum, RS; Resnick, RB; Thomas, MA; Washton, AM | 1 |
| Khazan, N; Steinfels, GF; Young, GA | 1 |
| Ho, WK; Ma, L; Mehal, ZD; Ng, YH; Wen, HL; Wong, HK | 1 |
| Ahtee, L; Carlsson, A | 1 |
| Parkhouse, RJ | 1 |
| McKearney, JW; Smith, JB | 1 |
| Clouet, DH; O'Callaghan, JP; Williams, N | 1 |
| Donald, AG; Shah, NS | 1 |
| Sprague, GL; Takemori, AE | 1 |
| Mule, SJ; Resnick, RB; Verebey, K; Washton, A | 1 |
| Ciofalo, FR | 3 |
| Downs, DA; Wiley, JN | 1 |
| Donzanti, BA; Warwick, RO | 1 |
| Abellana-Intaphan, LA; Choulis, NH; Sandhu, BS | 1 |
| Huidobro, F | 1 |
| Hine, CH; Masten, LW; Way, EL | 1 |
| Masten, LW | 1 |
| Leander, JD | 1 |
| Anggård, E | 1 |
| Hui, FW; Krikun, E; Smith, AA | 1 |
| Abellana-Intaphan, L; Choulis, NH; Narang, PK | 1 |
| Blakis, M; Haas, N; Holmes, E; Ling, W; Litaker, M | 1 |
| Keegan, J; Lavenduski, C; Schooff, K | 1 |
| Cooperstein, J; Harris, M; Hough, G; Kauders, F; Resnick, R; Thomas, M | 1 |
| Bowen, DV; Field, FH; Garfield, JW; Gutjahr, CL; Kreek, MJ | 1 |
| Baeder, H; Herndon, BL; Paull, K; Ringle, DA | 1 |
| Brady, JV; Griffiths, RR; Wurster, RM | 1 |
| Carlson, KR; Eibergen, RD | 1 |
| Brocco, MJ; Killam, KF; Robinson, CA | 1 |
| Brady, JP; O'Brien, CP; O'Brien, TJ; Testa, T; Wells, B | 1 |
| Kestenbaum, RS; Poole, D; Resnick, RB; Washton, A | 1 |
| Rich, CR; Stockdale, SL; Wang, RI; Wiesen, RL | 1 |
| Leander, JD; McMillan, DE | 1 |
| Stickney, JL | 1 |
| Leander, JD; Lucot, JB | 1 |
| Hollister, LE; Kasper, P; Schwin, RL | 1 |
| Crofford, MJ; Hui, FW; Smith, AA | 1 |
| Goldfrank, LR; Persky, VW | 1 |
| Jhamandas, K; Moffat, JA | 1 |
| Haigler, HJ | 1 |
| Holtzman, SG; Shannon, HE | 1 |
| Lunde, PK; Skjoto, J; Teisberg, P | 1 |
| Henwood, RW; Mazurkiewicz-Kwilecki, I | 1 |
| McNamee, HB; Meyer, RE; Mirin, SM | 1 |
| Berg, EP; Henkel, JG; Portoghese, PS | 1 |
| Amico, L; Landsberg, R; Plumb, M; Taintor, Z; Wicks, N | 1 |
| Chen, RC; Ho, AK | 1 |
| Blachly, PH | 3 |
| Rodzvilla, JP; Sesso, AM | 1 |
| Calabro, JJ; Neaderthal, RL | 1 |
| Duncalf, D; Foldes, FF; Jeyaram, C; Tarter, R | 1 |
| Holtzman, SG | 1 |
| Comaty, JE; Ehrenpreis, S; Greenberg, J | 1 |
| Dahlstrom, J; Medzihradsky, F | 1 |
| Halbach, H | 1 |
| Deacon, MA; Iorio, LC; Ryan, EA | 1 |
| Cox, BM; Ginsburg, M; Willis, J | 1 |
| Henwood, RW; Mazurikiewicz-Kwilecki, IM | 1 |
| Hron, V; Jhamandas, K; Sutak, M | 1 |
| Henderson, GL; Rosenkranz, RP | 1 |
| O'Brien, CP | 1 |
| Goldstein, A | 2 |
| Greenstein, RA; Mintz, J; O'Brien, CP; Woody, GE | 1 |
| Kauders, F; Schecter, A | 1 |
| Henderson, GL; Westkaemper, R | 1 |
| Harris, LS; Leander, JD; McMillan, DE | 1 |
| Gershon, S; Hine, B; Torrelio, M | 1 |
| Alkadhi, KA; Hogan, YH | 1 |
| Aronson, MJ; Cochrane, KJ; Handelsman, L; Kanof, PD; Ness, R | 1 |
| Holdcroft, A; Nicol, ME | 1 |
| Bigelow, GE; Liebson, IA; Preston, KL; Strain, EC | 3 |
| Chao, C; Click, RE; Gekker, G; Molitor, TW; Murtaugh, MP; Peterson, PK | 1 |
| Kleber, HD; Kosten, TR; Morgan, C | 1 |
| Yanagita, T | 1 |
| Kosten, TR; Kreek, MJ; Morgan, C | 1 |
| Olley, JE; Pierce, TL; Tiong, GK | 1 |
| Culpepper-Morgan, JA; Foley, K; Houde, RW; Inturrisi, CE; Kreek, MJ; Marsh, F; Portenoy, RK | 1 |
| Bigelow, GE; Liebson, IA; Stitzer, ML; Wright, C | 1 |
| Bigelow, GE; Felch, LJ; June, HL; Stitzer, ML; Wright, C | 1 |
| Bigelow, GE; Liebson, IA; Preston, KL | 5 |
| Bigelow, GE; Liebson, I; Preston, KL; Strain, EC | 1 |
| Aronson, MJ; Cochrane, KJ; Handelsman, L; Kanof, PD; Ness, R; Rubinstein, KJ | 1 |
| Negus, SS; Picker, MJ; Powell, KR | 1 |
| Dykstra, LA; Oliveto, AH; Picker, MJ | 1 |
| Fudala, PJ; Jaffe, JH; Johnson, RE | 1 |
| Aronson, MJ; Cochrane, KJ; Handelsman, L; Horvath, TB; Kanof, PD; Ness, R | 1 |
| Grünberger, J; Linzmayer, L; Loimer, N; Schmid, R | 1 |
| Kreek, MJ; Novick, DM; Ochshorn, M | 1 |
| Grünberger, J; Linzmayer, L; Loimer, N; Presslich, O | 1 |
| Lenz, K; Loimer, N; Presslich, O; Schmid, R | 1 |
| Gayle, MO; Nazarali, S; Ryan, CA | 1 |
| Chariot, J; Nagain, C; Roze, C; Vaille, C | 1 |
| Ling, W; Wesson, DR | 1 |
| Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ | 1 |
| Charney, DS; Kleber, HD; Kosten, TR; Krystal, JH; Morgan, CH; Price, LH | 1 |
| Bickel, W; Bigelow, GE; Liebson, IA; Preston, KL | 1 |
| Foley, KM; Houde, RW; Inturrisi, CE; Moulin, DE; Nip, TJ; Reidenberg, B; Wallenstein, S; Weinberg, DS | 1 |
| Brummitt, C; Bullock, M; Gekker, G; Hitt, J; Pentel, P; Peterson, PK; Sharp, B; Simpson, M | 1 |
| Heninger, GR; Krystal, JH; Walker, MW | 1 |
| Creighton, FJ; Ghodse, AH | 1 |
| Bustamante, D; Paeile, C; Pelissier, T; Saavedra, H; Tampier, L; Vergara, V | 1 |
| Jacobsen, LK; Kosten, TR | 1 |
| Bianchi, MS; Kosten, TA; Kosten, TR | 1 |
| Deshpande, JK; Maxwell, LG; Yaster, M | 1 |
| Bigelow, GE; Stitzer, ML; Wright, C | 1 |
| Nader, MA; Thompson, T | 2 |
| Jacobsen, LK; Kosten, TA; Kosten, TR | 1 |
| Dykstra, LA; Massie, CA; Picker, M | 1 |
| Di Chiara, G; Imperato, A | 1 |
| Burke, CA; Posner, J | 1 |
| Neil, A; Terenius, L | 1 |
| Hellebrekers, LJ; Mol, JA; van den Brom, WE | 1 |
| Adler, MW; Geller, EB; Kirby, A; Messner, S; Robin, M | 1 |
| Jurand, A | 1 |
| Bucarelli, A; De Montis, MG; Devoto, P; Tagliamonte, A | 1 |
| Domino, EF | 1 |
| Choi, DW; Viseskul, V | 1 |
| Liu, SJ; Wang, RI | 2 |
| Cleary, J; Ho, B; Nader, M; Thompson, T | 1 |
| Contreras, E; Fernández, E; Villar, M | 1 |
| Antonaci, S; Bonomo, L; Jirillo, E; Serlenga, E; Ventura, MT | 1 |
| Dykstra, LA; Picker, M | 1 |
| el-Guebaly, N; O'Riordan, J | 1 |
| Lei, H; Peachey, JE | 1 |
| Inturrisi, CE; Yoburn, BC | 1 |
| Sanchez-Ramos, JR; Senay, EC | 1 |
| Sparber, SB | 1 |
| Dykstra, LA; Heise, JW; Picker, M | 1 |
| Arrizabalaga Cuesta, C; Zulaica, D | 1 |
| Côté, L; Fahn, S; Hening, W; Walters, A | 1 |
| Bewley, TH; Ghodse, AH; Kearney, MK; Smith, SE | 1 |
| Romac, DR | 1 |
| Appia, F; Chariot, J; Rozé, C; Vaille, C | 1 |
| Moerschbaecher, JM; Thompson, DM; Winsauer, PJ | 1 |
| Bartolome, MB; Kuhn, CM | 2 |
| Gorodetzky, CW | 1 |
| Casella, G; Clouet, DH; Mule, SJ | 1 |
| Lewit, T | 1 |
| Caruso, FS; Gordon, M; Pachter, IJ | 1 |
| Africano, A; Kinsella, JK; Kleber, HD; Rapkin, RM | 1 |
| Collier, HO; Roy, AC | 2 |
| Elliott, HW; Garcia, JF; Kokka, N | 1 |
| Gourley, DR | 1 |
| Stesin, AJ; Takemori, AE; Tulunay, FC | 1 |
| Takemori, AE; Tulunay, FC | 1 |
| Lamid, S; Roh, BL; Wang, RI; Wiesen, RL | 1 |
| Marks, MJ; Medzihradsky, F | 1 |
| Goodlet, I; Sugrue, MF | 1 |
| Digregorio, GJ | 1 |
| Teiger, DG | 1 |
| Buchner, LH; Cimino, JA; Raybin, HW; Stewart, B | 1 |
| Edelman, I; Hiller, JM; Simon, EJ | 1 |
| Dickinson, G; Jhamandas, K | 1 |
| Kreek, MJ | 1 |
| Crofford, M; Hui, F; Smith, AA | 1 |
| Kaneto, H; Koida, M; Nakanishi, H | 1 |
| Burchard, JM | 1 |
| Simon, EJ | 1 |
| McMillan, DE | 1 |
| Blatman, S | 1 |
| Bloom, WA; Marcello, L; Sudderth, EW | 1 |
| Knowles, RR; Parwatikar, S | 1 |
| Kersh, ES | 1 |
| Pert, CB; Snyder, SH | 1 |
| Murphree, HB | 1 |
| Hui, F; Smith, AA | 1 |
| Arena, JM | 1 |
| Carmichael, FJ; Israel, Y | 1 |
| Colasanti, B; Khazan, N | 1 |
| Crofford, M; Smith, AA | 1 |
| Klimt, CR; Seibel, JE; Waldron, VD | 1 |
| Simons, PS | 1 |
| Granat, FR; Saelens, JK | 1 |
| Holcenberg, JS | 1 |
| Kersh, ES; Schwartz, LK | 1 |
| Horng, JS; Wong, DT | 1 |
| Montel, H; Starke, K | 1 |
| Gray, AP; Robinson, DS | 1 |
| Bloom, WA; Caruso, FS; Monteleone, P; Van Harken, DR | 1 |
| Haddow, JE; Lee, KD; Lovejoy, FH | 1 |
| Jasinski, DR; Nutt, JG | 1 |
| Gorodetzky, CW; Kullberg, MP | 1 |
| Myers, MB; Smits, SE | 1 |
| Calimlim, JF; Davis, HT; Gillies, AJ; Lasagna, L; Wardell, WM | 1 |
| Booher, R; Miles, H; Nickander, R | 1 |
| Beeler, GW; Kerr, FW; Triplett, JN | 1 |
| Ahtee, L | 1 |
| Maugh, TH | 1 |
| Hilburn, MB | 1 |
| Hornykiewicz, O; Kuschinsky, K | 1 |
| Gordon, E | 1 |
| Fink, M; Freedman, AM; Resnick, R; Zaks, A | 1 |
| Bigelow, GE; Liebson, IA; Preston, KL; Stitzer, ML | 1 |
| Rawson, RA; Resnick, RB; Tennant, FS; Washton, AM | 2 |
| Cabib, S; Mele, A; Puglisi-Allegra, S | 1 |
| Browne, RG; Segal, DS | 1 |
| Amsterdam, EA; Henderson, GL; Mason, DT; Rendig, SV | 1 |
| Janowsky, DS; Judd, LL | 1 |
| Blazsó, G; Minker, E; Végh, A | 1 |
| Cerdeño Impuesto, V | 1 |
| Carlson, KR; Seeger, TF | 1 |
| Clemens, JA; Shaar, CJ | 1 |
| Schecter, A | 1 |
| Burwell, B; Lau, C; Slotkin, TA | 1 |
| Bläsig, J; Dum, J; Herz, A | 1 |
| Huidobro, F; Huidobro-Toro, JP | 1 |
| Extein, I; Finn, LB; Gold, MS; Kleber, HD; Martin, DA; Pottash, AL; Sweeney, DR | 1 |
| Gold, MS; Kleber, HD | 1 |
| Chantry, CJ; Seidler, FJ; Slotkin, TA | 1 |
| Extein, I; Gold, MS; Kleber, HD; Martin, D; Pottash, AC | 1 |
| Hu, J; Huidobro-Toro, JP; Rezvani, A; Way, EL | 1 |
| Angioi, RM; Curreli, V; De Montis, GM; Devoto, P; Tagliamonte, A | 1 |
| Dewey, WL; Snow, AE | 1 |
| Frantz, AG; Kreek, MJ; Ragavan, VV; Wardlaw, SL | 1 |
| Krystal, JH; Redmond, DE | 1 |
| Huey, LY; Janowsky, DS; Judd, LL; Risch, SC; Segal, DS | 1 |
| Childress, AR; Ehrman, RN; McLellan, AT; O'Brien, CP; Ternes, J | 1 |
| Dewey, WL | 1 |
| Bigelow, GE; Sherman, MF; Singleton, EG | 1 |
| Kleber, HD; Kosten, TR | 1 |
| Tenenbein, M | 1 |
| Charney, DS; Galloway, MP; Heninger, GR; Kleber, HD; Murberg, M; Redmond, DE; Roth, RH | 1 |
| Beverley, CL; Borenfreund, E; Higgins, PJ | 1 |
| Greenstein, RA; Resnick, E; Resnick, RB | 1 |
| Inturrisi, CE; Ling, GS; Tappe, NS | 1 |
| Leander, JD; Zimmerman, DM | 1 |
| Filipenko, JD; Nanji, AA | 1 |
| Blandina, P; Botti, P; Caramelli, L; Fantozzi, R; Ledda, F; Mannaioni, PF; Masini, E; Moroni, F; Peruzzi, S; Zorn, AM | 2 |
| Kuwahara, MD; Sparber, SB | 2 |
| Beck, EC; Dustmann, RE; Shearer, DE; Snyder, EW | 1 |
| Kogan, MJ; Mulè, SJ; Verebey, K | 1 |
| Domino, EF; Ruffing, DM | 1 |
| Bartolome, MQ; Kuhn, CM | 1 |
| Coulthard, K; Gourlay, GK | 1 |
| Cushman, P | 1 |
| Gaut, ZN; Nauss-Karol, C; VanderWende, C | 1 |
| Lichtblau, L; Sparber, SB | 2 |
| Ahluwalia, BS; Purohit, V; Singh, HH | 2 |
| Leander, JD; McCleary, PE | 1 |
| Juskevich, JC; Lovenberg, W; O'Callaghan, JP | 1 |
| Hasegawa, AT; Kochar, C; Roh, BL; Wang, RI | 1 |
| De Montis, GM; Devoto, P; Tagliamonte, A | 1 |
| Tung, AS; Yaksh, TL | 1 |
| Braverman, P; Charney, DS; Heninger, GR; Kleber, HD; Murburg, M; Redmond, DE; Riordan, CE; Sternberg, DE | 1 |
| Masten, LW; Way, EL | 1 |
| Burklund, KE; Lichtblau, L; Sparber, SB | 1 |
| McLaughlin, PJ; Zagon, IS | 1 |
| Nencini, P; Paroli, E | 1 |
| Kuehnle, JC; Mello, NK; Mendelson, JH; Sellers, MS | 1 |
| McGivney, WT; McMillan, DE | 1 |
| Britten, AJ; Ghodse, H; Greaves, JL; Lynch, D; Taylor, DR | 1 |
| Charney, DS; Hoffer, PB; Kosten, TR; Krystal, JH; Price, LH; Rosen, MI; Seibyl, JP; van Dyck, CC; Woods, SW; Zubal, IG | 1 |
| Farrell, M | 1 |
| Binchy, JM; Manning, J; Molyneux, EM | 1 |
| Adelson, MO; Albeck, H; Hahn, EF; Khuri, E; Kreek, MJ; Novick, DM | 1 |
| Cutler, R; Fishbain, DA; Rosomoff, HL | 1 |
| Cibin, M; Ferrara, SD; Gallimberti, L; Gessa, GL; Pagnin, P; Pani, PP; Pirastu, R; Sabbion, R | 1 |
| Gill, TS; Kosten, TR; Kreek, MJ; Margolin, A; McMahon, TJ; Pearsall, HR; Rosen, MI; Woods, SW | 1 |
| Forrest, AR; Gerrish, SP; Hendra, TJ | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Gölz, J | 1 |
| Hope, W; Pierce, TL; Raper, C | 1 |
| Beattie, T; Nichol, N; Pieterse, L | 1 |
| Finfer, S | 1 |
| Dettling, M; Tretter, F | 1 |
| Hameedi, FA; Kosten, TR; Pearsall, HR; Rosen, MI; Woods, SW | 1 |
| Batki, SL; Brown, J; Jones, RT; Mendelson, J; Welm, S | 1 |
| Elliott, KJ; Inturrisi, CE; Shimoyama, M; Shimoyama, N | 1 |
| Escribá, PV; García-Sevilla, JA; Mayor, F; Murga, C; Ozaita, A; Ventayol, P | 1 |
| Holtzman, SG; Kimmel, HL | 1 |
| Hameedi, FA; Kosten, TA; Kosten, TR; Oliveto, AH; Rosen, MI; Woods, SW | 1 |
| Briggs, SL; Rech, RH; Sawyer, DC | 1 |
| Sams-Dodd, F | 1 |
| Gastpar, M; Kaube, H; Kienbaum, P; Klein, S; Peters, J; Scherbaum, N | 1 |
| Hirtl, C; Pfab, R; Zilker, T | 1 |
| Bigelow, GE; Buchhalter, AR; Eissenberg, T; Stitzer, ML; Walsh, SL | 1 |
| Meisch, RA; Stewart, RB; Wang, NS | 1 |
| Gong, ZH; Liao, XP; Liu, JG; Qin, BY | 1 |
| Daenens, P; Tytgat, J; Ulens, C | 1 |
| Davido, A; Edel, Y; Gratien, M; Levy, A; Masmoudi, R; Sembach, N | 1 |
| Bocchi, C; Delsignore, R; Fontanesi, B; Gerra, G; Rustichelli, P; Timpano, M; Zaimovic, A; Zambelli, U | 1 |
| Gastpar, M; Kienbaum, P; Michel, MC; Peters, J; Scherbaum, N; Thürauf, N | 1 |
| Carpenter, KJ; Chapman, V; Dickenson, AH | 1 |
| Ng, KF; Pang, P; Shan, J; Yang, JC | 1 |
| Scholz, M | 1 |
| Cañadas, F; Rice, KC; Riley, AL; Stevenson, GW; Zhang, X | 1 |
| Chizh, BA; Englberger, W; Scheede, M; Schlütz, H | 1 |
| Gastpar, M; Heuter, T; Kienbaum, P; Michel, MC; Peters, J; Scherbaum, N | 1 |
| Yui, K | 1 |
| Caggiano, AO; Schwab, J | 1 |
| Clarke, S; Dargan, P | 1 |
| Carlos, MP; Chuang, LF; Chuang, RY; Doi, RH; Suzuki, S; Torres, JV | 1 |
| Benbrick, N; Leblanc, A; Moreau, MH | 1 |
| Kreek, MJ; Vocci, FJ | 1 |
| Daniels, AM; Ferner, RE | 1 |
| Sporer, KA | 1 |
| Aks, SE; Mycyk, MB; Szyszko, AL | 1 |
| de Silva-Rossdeutscher, E; Drummond, PD | 1 |
| Funada, M | 1 |
| Hammer, B; Kleinschmidt, S; Risch, B; Wilhelm, W | 1 |
| Gonsai, K; Kosten, TR; Oliveto, A; Poling, J | 1 |
| Belcheva, MM; Clark, AL; Coscia, CJ; Hou, Y; Tan, Y; Zahm, DS | 1 |
| Bernhard, M; Gries, A; Hainer, C | 1 |
| Greenwald, MK; Roehrs, TA | 1 |
| Greenwald, MK | 1 |
| Irvine, RJ; Lewanowitsch, T; Miller, JH | 1 |
| Negus, SS | 1 |
| Calsyn, DA; Malcy, JA; Saxon, AJ | 1 |
| Guffens, JM | 1 |
| Buisine, A; Chevret, L; Decobert, M; Devictor, D; Durand, P; Haas, V; Tiras, S; Tissières, P | 1 |
| Brewer, C | 1 |
| Bearn, J; Best, D; Beswick, T; Gossop, M; McCambridge, J; Rees, S; Strang, J | 1 |
| Gibert-Rahola, J; Mico, JA; Rojas-Corrales, MO | 1 |
| Fiellin, DA; Friedland, GH; Gourevitch, MN | 1 |
| Bruce, RD; Eldred, L; Fiellin, DA; Finkelstein, R; Haltiwanger, D; Lucas, GM; Sullivan, LE | 1 |
| D'Incognito, C; LoVecchio, F; Pizon, A; Riley, B; Sami, A | 1 |
| Bardin, C; Baud, FJ; Bloch, V; Chast, F; Declèves, X; Mégarbane, B | 1 |
| Darke, S; Havard, A; Mills, KL; Ross, J; Teesson, M; Williamson, A | 1 |
| González Castro, A; Martín Egaña, M; Suberviola Cañas, B; Teja Barbero, JL | 1 |
| Dejgaard, B | 1 |
| Grönbladh, L; Heilig, M; Kakko, J; Nilsson, LH; Rawlings, B; Rück, C; Svanborg, KD; von Wachenfeldt, J | 1 |
| Calello, DP; Osterhoudt, KC | 1 |
| Bigelow, GE; Rosado, J; Strain, EC; Walsh, SL | 1 |
| Alho, H; Fabritius, C; Kalska, H; Rapeli, P; Salaspuro, M; Wahlbeck, K | 1 |
| Arnsten, JH; Gourevitch, MN; Kunins, HV; Whitley, SD | 1 |
| Amass, L; Bower, EH; Branstetter, SA; Kamien, J | 1 |
| Pountney, AJ; Ridgway, ZA | 1 |
| Abraham, SL; Nelson, CS; Nettleton, RT; Olsen, GD; Ransom, TA | 1 |
| Byrne, A; Wodak, A | 1 |
| Roberts, JR; Wong, SC | 1 |
| Brandão-Neto, RA; Bugano, D; Giannini, FP; Martins, HS; Santana, AN; Scalabrini-Neto, A; Silva, RV; Velasco, IT | 1 |
| Bird, SB; Rosenbaum, C | 1 |
| Kleber, HD | 1 |
| Bailey, CP; Braksator, E; Goodchild, S; Henderson, G; Kelly, E; Marrion, NV; Rodriguez-Martin, I | 1 |
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| Ali, R; Degenhardt, L; Dietze, P; Jenkinson, R; Larance, B; Lintzeris, N; Mattick, R; White, N | 1 |
| Bruce, D; Chhatre, S; Hillhouse, M; Jacobs, P; Korthuis, PT; Ling, W; Metzger, D; Poole, S; Saxon, AJ; Sorensen, J; Woody, GE | 1 |
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| Bruce, D; Chhatre, S; Hillhouse, M; Jacobs, P; Korthuis, PT; Ling, W; Metzger, D; Poole, S; Saxon, AJ; Sorensen, J; Woody, G | 1 |
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| Conroy, S; Hill, D | 1 |
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| Swenson, O | 1 |
| Joseph, H; Maghsoudi, N; Phillips, BW; Stancliff, S | 1 |
| Díaz, T; Domínguez-Hernández, R; Fernández, JM; Forcada, R; Martínez, JM; Oyagüez, I; Roncero, C; Seijo, P; Terán, A | 1 |
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| Diwakarla, S; Grönbladh, A; Hallberg, M; Nyberg, F; Nylander, E; Zelleroth, S | 1 |
| Hassanian-Moghaddam, H; Zamani, N | 1 |
| Brogly, SB; Davies, G; Dow, K; Johnson, A; Lajkosz, K; Newman, A; Turner, S | 1 |
| Gharehdaghi, J; Hassanian-Moghaddam, H; Hedayatshode, MJ; Takalloo-Bakhtiari, A; Zamani, N | 1 |
| Fox, LM; Hoffman, RS; Manini, AF; Vlahov, D | 1 |
| Breault, DT; Burns, MM; Stefater, MA; Toce, MS | 1 |
| Asatryan, A; Geoffroy, P; Kort, J; Kosloski, MP; Liu, W; Zhao, W | 1 |
| Hassanian-Moghaddam, H; Kabir, A; Khosravi, N; Ostadi, A; Rahimi, M; Zamani, N | 1 |
| Beasley, C; Bobak, TJ; Callahan, S; Dovale, I; Gelfman, N; Jason, LA; Majer, JM; Nguyen, HM; Norris, J; Ogata, M; Siegel, J; Stecker, E; Wiedbusch, E | 1 |
| Kiefer, L; Kouyoumdjian, FG; Patel, A; Regenstreif, L; To, MJ | 1 |
| Bujalska-Zadrożny, M; de Cordé, A; Filip, M; Kleczkowska, P; Krząścik, P; Wolińska, R | 1 |
| Bishop, B; Deering, D; Gilmour, J | 1 |
| James, DL; Jowza, M | 1 |
| Chen, BC; Lebin, JA; Valento, MJ | 1 |
| Begovac, J; Bozicevic, I; Handanagic, S; Rutherford, GW; Sekerija, M | 1 |
| Crowley, D; Delargy, I; Van Hout, MC | 1 |
| Fairbairn, N; Gorfinkel, L; Jones, AA; Klimas, J; McCarty, D; Priest, KC | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Caffaro, MM; Fennell, TR; Mortensen, NP; Snyder, RW; Yueh, YL | 1 |
| Babu, KM; Brent, J; Juurlink, DN | 1 |
| Hills-Evans, K; Hsu, D; Marshall, J; O'Donoghue, S; Reichheld, AM; Sheehan, JK; Stevens, JP; Tandon, M; Tocci, NX | 1 |
| Cousins, S; McCann, M; Pearce, R; Rawson, RA; Rieckmann, T | 1 |
| Degenhardt, L; Gisev, N; Hall, WD; Roxburgh, A | 1 |
| Homayra, F; Hongdilokkul, N; McGowan, G; Min, JE; Nosyk, B; Pearce, LA; Piske, M; Socias, ME; Zhou, H | 1 |
| Buckley, NA; Hassanian-Moghaddam, H; Zamani, N | 1 |
| Homayra, F; Irvine, M; McGowan, G; Min, JE; Nosyk, B; Pearce, LA; Piske, M; Slaunwhite, A; Zhou, H | 1 |
| Rodríguez Mega, E | 1 |
| Chevillard, L; Mégarbane, B; Vodovar, D | 1 |
| Amirabadizadeh, A; Brent, J; Hoyte, C; Mehrpour, O | 1 |
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| Baron, CA; Blinova, K; Johannesen, L; Patel, D; Randolph, AL; Ren, M; Sheng, J; Strauss, DG; Thiebaud, N; Tran, PN; Volpe, DA; Wu, M; Wu, WW | 1 |
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| Farnaghi, F; Gholami, N; Hassanian-Moghaddam, H; McDonald, R; Saberi, M; Zamani, N | 1 |
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| Bart, G; Bielavitz, S; Cook, RR; Giang, LM; Khuyen, TT; King, C; Korthuis, PT; Kunkel, LE; Nguyen, DB; Nguyen, T; Tam, NTM; Thuy, DT | 1 |
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| Asch, SM; Bounthavong, M; Brandeau, ML; Combs, A; Fairley, M; Goldhaber-Fiebert, JD; Humphreys, K; Joyce, VR; Oliva, EM; Owens, DK; Trafton, J | 1 |
| Homayra, F; Marchand, C; Mead, A; Min, JE; Ng, J; Nosyk, B; Piske, M; Woolner, M; Zhou, H | 1 |
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| Bastien, G; Brissette, S; Bruneau, J; Eugenia Socias, M; Foll, BL; Jutras-Aswad, D; Ledjiar, O; Lim, R; Marsan, S; McAnulty, C; Talbot, A | 1 |
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| Caputo, A; Christopher, C; Compton, P; Delgado, MK; Lowenstein, M; McFadden, R; Olenik, JM; Perrone, J; Ronning, K; Sigueza, AL; Thakrar, AP; Uritsky, TJ; Winston, A | 1 |
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49 review(s) available for methadone and naloxone
| Article | Year |
|---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methadone; Morphine; Morphine Dependence; Naloxone; Propranolol; Protein Binding; Sex Factors; Substance-Related Disorders | 1976 |
Possible involvement of cerebroside sulfate in opiate receptor binding.
Topics: Animals; Azure Stains; Binding Sites; Brain; Cerebrosides; Humans; Levorphanol; Methadone; Mice; Naloxone; Receptors, Neurotransmitter; Receptors, Opioid; Sulfanilic Acids | 1978 |
Methadone maintenance and narcotic blocking drugs. Appendix.
Topics: Administration, Oral; Cyclazocine; Drug Tolerance; Heroin Dependence; Humans; Injections, Subcutaneous; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Research; Substance Withdrawal Syndrome | 1977 |
Drug interactions with methadone.
Topics: Adult; Aged; Chromatography, Gas; Drug Interactions; Feces; Female; Heroin Dependence; Humans; Liver; Male; Mass Spectrometry; Methadone; Methods; Middle Aged; Naloxone; Rifampin; Substance Withdrawal Syndrome; Tuberculosis, Pulmonary | 1976 |
[Overview of the progress in drug dependence studies--mainly focussing on psychic dependence].
Topics: Animals; Benzodiazepines; Haloperidol; Humans; Limbic System; Methadone; Naloxone; Receptors, Dopamine; Substance-Related Disorders | 1992 |
In vivo and in vitro studies of opiates and cellular immunity in narcotic addicts.
Topics: Adult; Antibody Formation; Cells, Cultured; Cytotoxicity, Immunologic; Disease Susceptibility; Endorphins; Heroin Dependence; HIV Infections; Humans; Immunologic Deficiency Syndromes; Killer Cells, Natural; Life Style; Male; Methadone; Middle Aged; Naloxone; Narcotics; Neurosecretory Systems; Opioid-Related Disorders; Stereoisomerism; T-Lymphocyte Subsets | 1991 |
Drugs of abuse--opiates.
Topics: Central Nervous System; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotics; Opioid-Related Disorders; Primary Health Care; Receptors, Opioid | 1990 |
The pharmacologic management of pain in children.
Topics: Analgesia, Epidural; Analgesics; Child; Child, Preschool; Codeine; Fentanyl; Humans; Infant; Meperidine; Methadone; Morphine; Naloxone; Narcotics; Pain | 1989 |
Receptor mechanisms for nociception.
Topics: Analgesics, Opioid; Animals; Codeine; Drug Tolerance; Methadone; Morphine; Naloxone; Neurons, Afferent; Nociceptors; Opioid-Related Disorders; Receptors, Opioid; Spinal Cord | 1986 |
Developmental effects of narcotics.
Topics: Analysis of Variance; Animals; Body Weight; Female; Fetal Diseases; Growth; Humans; Methadone; Naloxone; Narcotics; Placental Insufficiency; Pregnancy; Prenatal Exposure Delayed Effects; Research Design; Substance Withdrawal Syndrome | 1986 |
[Pulmonary diseases due to drugs. II].
Topics: Amines; Amitriptyline; Beclomethasone; Drug-Related Side Effects and Adverse Reactions; Heroin; Humans; Hydantoins; Lung Diseases; Methadone; Naloxone; Oxazoles; Pneumonia, Aspiration; Respiratory Therapy; Sulfasalazine; Ventilators, Mechanical | 1974 |
Interactions of narcotic antagonists with receptor sites.
Topics: Acetylcholine; Animals; Atropine; Binding Sites; Brain; Chromatography; Drug Tolerance; Electric Stimulation; Haplorhini; Humans; Kinetics; Levorphanol; Methadone; Mice; Molecular Conformation; Morphine; Naloxone; Narcotic Antagonists; Rats; Receptors, Drug; Structure-Activity Relationship; Substance Withdrawal Syndrome; Time Factors | 1973 |
Methadone and naloxone in combination (Naldone) for the treatment of heroin addicts.
Topics: Administration, Oral; Animals; Biological Availability; Dosage Forms; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation; Drug Evaluation, Preclinical; Haplorhini; Heroin Dependence; Humans; Injections, Intravenous; Methadone; Naloxone; Pupil; Rats; Substance Withdrawal Syndrome; Time Factors | 1973 |
Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.
Topics: Adenylyl Cyclases; Animals; Aspirin; Brain; Cyclic AMP; Depression, Chemical; Fluorides; Guinea Pigs; Heroin; In Vitro Techniques; Levorphanol; Meperidine; Methadone; Mice; Morphinans; Morphine; Naloxone; Prostaglandin Antagonists; Prostaglandins; Rabbits; Rats; Receptors, Drug; Sodium; Stimulation, Chemical | 1974 |
[Management of opium addicts using opiates and their antagonists].
Topics: Crime; Cyclazocine; Economics; Germany, West; Heroin; Humans; Methadone; Morphine Dependence; Naloxone; Narcotic Antagonists | 1972 |
In search of the opiate receptor.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Chromatography, Affinity; Cyclopropanes; Indicators and Reagents; Intestines; Levorphanol; Methadone; Morphinans; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentanols; Rats; Receptors, Drug; Tritium | 1973 |
Effects of narcotics and narcotic antagonists on operant behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Chlorpromazine; Columbidae; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Tolerance; Humans; Methadone; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Reinforcement Schedule; Substance Withdrawal Syndrome | 1973 |
Narcotic poisoning of children (1) through accidental ingestion of methadone and (2) in utero.
Topics: Administration, Oral; Apgar Score; Birth Weight; Child; Child Care; Female; Gestational Age; Heroin Dependence; Humans; Infant, Newborn; Levallorphan; Maternal-Fetal Exchange; Methadone; Nalorphine; Naloxone; Phenobarbital; Poisoning; Pregnancy; Substance Withdrawal Syndrome; Tablets | 1974 |
[Narcotic withdrawal syndrome. Therapeutic methods].
Topics: Acupuncture Therapy; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesia; Brain; Central Nervous System Agents; Clonidine; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1982 |
The role of narcotic antagonists in the rehabilitation of opiate addicts: a review of naltrexone.
Topics: Clinical Trials as Topic; Double-Blind Method; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Receptors, Opioid | 1980 |
Multiple mechanisms of withdrawal from opioid drugs.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Benzodiazepines; Calcium; Calmodulin; Clonidine; Conditioning, Psychological; Cyclic GMP; Dopamine; Drug Tolerance; Enkephalins; Fear; gamma-Aminobutyric Acid; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Norepinephrine; Protein Conformation; Receptors, Opioid; Serotonin; Substance Withdrawal Syndrome | 1984 |
Behavioral and neuroendocrine effects of opioid receptor agonists in psychopathologic states.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Depressive Disorder; Endorphins; Humans; Hydrocortisone; Male; Methadone; Middle Aged; Naloxone; Narcotics; Prolactin; Schizophrenia | 1983 |
Opiate withdrawal.
Topics: Animals; Brain; Conditioning, Classical; Humans; Methadone; Motivation; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Receptors, Opioid; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 1994 |
Opiate detoxification protocols. A clinical manual.
Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Psychiatric Status Rating Scales; Receptors, Opioid; Substance Withdrawal Syndrome | 1993 |
[Ambulatory medical treatment of drug dependent patients].
Topics: Ambulatory Care; Heroin Dependence; Humans; Illicit Drugs; Methadone; Naloxone; Narcotic Antagonists; Physician-Patient Relations; Primary Health Care; Psychotropic Drugs; Substance-Related Disorders; Treatment Outcome | 1996 |
History and current status of opioid maintenance treatments: blending conference session.
Topics: Buprenorphine; Clinical Trials as Topic; History, 20th Century; Humans; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders | 2002 |
Strategies for preventing heroin overdose.
Topics: Analgesics, Opioid; Drug Overdose; Heroin; Heroin Dependence; Humans; Methadone; Naloxone; Narcotic Antagonists; Patient Education as Topic | 2003 |
Opioid dependence: rationale for and efficacy of existing and new treatments.
Topics: Buprenorphine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Prognosis; Risk Assessment; Substance Abuse Detection; Substance Withdrawal Syndrome; Treatment Outcome | 2006 |
Initial strategies for integrating buprenorphine into HIV care settings in the United States.
Topics: Antiretroviral Therapy, Highly Active; Buprenorphine; Centers for Disease Control and Prevention, U.S.; Delivery of Health Care, Integrated; Female; Health Resources; Health Services Needs and Demand; HIV Infections; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Patient Selection; Primary Health Care; Program Evaluation; Risk Assessment; Substance Abuse Treatment Centers; United States | 2006 |
Should naloxone be prescribed in the ED management of patients with cardiac arrest? A case report and review of literature.
Topics: Analgesics, Opioid; Emergency Service, Hospital; Female; Heart Arrest; Humans; Methadone; Middle Aged; Naloxone; Narcotic Antagonists | 2008 |
Pharmacologic treatments for opioid dependence: detoxification and maintenance options.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2007 |
Narrative review: buprenorphine for opioid-dependent patients in office practice.
Topics: Adult; Buprenorphine; Drug Combinations; Female; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Patient Care Planning; Physician's Role; Primary Health Care | 2008 |
Practical considerations for the clinical use of buprenorphine.
Topics: Buprenorphine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Education, Continuing; Health Services Accessibility; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Patient Education as Topic; Patient Selection | 2004 |
Accidental methadone ingestion in an infant: case report and review of the literature.
Topics: Female; Humans; Infant; Methadone; Naloxone; Narcotic Antagonists; Narcotics | 2009 |
Buprenorphine/naloxone: a review of its use in the treatment of opioid dependence.
Topics: Buprenorphine; Clinical Trials as Topic; Drug Combinations; Drug Interactions; Humans; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders | 2009 |
Maintenance treatments for opiate dependent adolescent.
Topics: Adolescent; Buprenorphine; Humans; Methadone; Methadyl Acetate; Naloxone; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Young Adult | 2009 |
The pharmacological treatment of opioid addiction--a clinical perspective.
Topics: Adrenergic Agonists; Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Social Support; Substance Withdrawal Syndrome | 2010 |
Acute pain management in opioid-tolerant patients: a growing challenge.
Topics: Acute Disease; Analgesics; Analgesics, Opioid; Animals; Australia; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Tolerance; Humans; Hyperalgesia; Illicit Drugs; Methadone; Naloxone; Narcotic Antagonists; Narcotics; New Zealand; Opiate Substitution Treatment; Opioid-Related Disorders; Pain; Pain, Postoperative; Patient Discharge; Preoperative Care; Substance Withdrawal Syndrome | 2011 |
Management of opioid substitution therapy during medical intervention.
Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases; Mental Disorders; Methadone; Naloxone; Opiate Substitution Treatment; Pain; Pain Management; Palliative Care; Polypharmacy; Pregnancy; Pregnancy Complications; Respiratory Insufficiency; Substance-Related Disorders; Virus Diseases | 2012 |
Problem based review: The patient taking methadone.
Topics: Adult; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders | 2013 |
Maintenance treatments for opiate -dependent adolescents.
Topics: Adolescent; Buprenorphine; Humans; Maintenance Chemotherapy; Methadone; Methadyl Acetate; Naloxone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic | 2014 |
Caring for patients with opioid use disorder in the hospital.
Topics: Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Overdose; Hospitalization; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Respiration, Artificial; Substance Withdrawal Syndrome | 2016 |
Treating Opioid Dependence: Pain Medicine Physiology of Tolerance and Addiction.
Topics: Analgesics, Opioid; Buprenorphine; Cognitive Behavioral Therapy; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Practice Patterns, Physicians' | 2019 |
Twenty years of the methadone treatment protocol in Ireland: reflections on the role of general practice.
Topics: General Practice; Harm Reduction; History, 20th Century; History, 21st Century; Humans; Ireland; Methadone; Naloxone; Narcotic Antagonists; Narcotic-Related Disorders; Narcotics; Needle-Exchange Programs; Opiate Substitution Treatment | 2019 |
Prevention of Opioid Overdose.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Pain; Drug Overdose; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Risk Assessment; Substance Abuse Detection | 2019 |
Topics: Acyclic Monoterpenes; Adipose Tissue; Adolescent; Adult; Aged; Aged, 80 and over; Air Pollutants; Air Pollutants, Occupational; Amino Acid Transport Systems; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Arthrobacter; Bacteria; Bacteriological Techniques; Benzaldehydes; Biodegradation, Environmental; Biofilms; Biological Transport; Biomarkers; Biomass; Bioreactors; Body Composition; Body Mass Index; Brassica; Brazil; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Caco-2 Cells; Cadmium; Calcium; Calcium Carbonate; Calcium Channels; Catalysis; Cell Degranulation; Cell Line; Cell Membrane; Chitosan; Chromatography, High Pressure Liquid; Chromium; Cobalt; Cohort Studies; Colony Count, Microbial; Composting; Copper; COVID-19; Cross-Sectional Studies; Cytoplasm; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Diarrhea; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Drug Implants; Drug Stability; Drug Synergism; Electroplating; Endometrial Neoplasms; Endometrium; Environmental Monitoring; Environmental Restoration and Remediation; Estradiol; Estrogens; Feces; Female; Food Microbiology; Food Preservation; Fruit and Vegetable Juices; Gasotransmitters; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Glutathione; Gold; Graphite; Growth Hormone; Harm Reduction; Hot Temperature; Humans; Hydrocortisone; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydrogen-Ion Concentration; Ileum; Imidazoles; Injections, Intraperitoneal; Insecticides; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Intestinal Absorption; Light; Lignin; Liver; Magnetics; Male; Manganese; Mast Cells; Melanoma; Membrane Potentials; Metals; Methadone; Microbial Viability; Microplastics; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Middle Aged; Mitochondrial Swelling; Molecular Dynamics Simulation; Monophenol Monooxygenase; Morocco; Naloxone; Naltrexone; Nanocomposites; Nanomedicine; Nanoparticles; Narcotic Antagonists; Neonicotinoids; Nitric Oxide; Nitro Compounds; Nitrogen; Nitrogen Compounds; Obesity; Obesity, Abdominal; Occupational Exposure; Ontario; Opiate Substitution Treatment; Opioid-Related Disorders; Oryza; Overweight; Oxidative Stress; Oxides; Oxygen; Perception; Photoelectron Spectroscopy; Plants; Plastics; Point Mutation; Polychlorinated Biphenyls; Polycyclic Aromatic Hydrocarbons; Potassium; Premenopause; Prodrugs; Prospective Studies; Protons; Pyrolysis; Qualitative Research; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resins, Synthetic; Rhodamines; Risk Factors; ROC Curve; Salmo salar; SARS-CoV-2; Seawater; Severity of Illness Index; Sewage; Social Media; Soil; Soil Microbiology; Soil Pollutants; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Staining and Labeling; Stainless Steel; Steel; Stress, Physiological; Substance Abuse Treatment Centers; Symporters; T-Lymphocytes; Toluene; Triclosan; Ultraviolet Rays; Waist Circumference; Waste Disposal, Fluid; Wastewater; Water Purification; Welding; X-Ray Diffraction; Young Adult | 2020 |
Economic Evaluation in Opioid Modeling: Systematic Review.
Topics: Analgesics, Opioid; Costs and Cost Analysis; Humans; Methadone; Models, Economic; Naloxone; Narcotic Antagonists; Opiate Overdose; Opiate Substitution Treatment; Opioid Epidemic; Opioid-Related Disorders | 2021 |
69 trial(s) available for methadone and naloxone
| Article | Year |
|---|---|
Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.
Topics: Adult; Blood Pressure; Buprenorphine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Euphoria; Humans; Male; Methadone; Middle Aged; Morphinans; Morphine; Naloxone; Narcotics; Pulse; Pupil; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Analgesia in clinical practice.
Topics: Acetaminophen; Analgesia; Analgesics; Aspirin; Clinical Trials as Topic; Drug Interactions; Heroin; Humans; Methadone; Morphine; Nalorphine; Naloxone; Pentazocine | 1977 |
Clinical evaluation of naltrexone treatment of opiate-dependent individuals. Report of the National Research Council Committee on Clinical Evaluation of Narcotic Antagonists.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Heroin; Heroin Dependence; Humans; Male; Methadone; Motivation; Naloxone; Naltrexone; Patient Compliance; Placebos; Research Design; Social Adjustment | 1978 |
Naltrexone in methadone maintenance patients electing to become "drug free".
Topics: Adult; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Patient Dropouts; Research Design | 1976 |
Comments and findings from a naltrexone double blind study.
Topics: Clinical Trials as Topic; Humans; Methadone; Naloxone; Naltrexone; Research Design; Statistics as Topic; Substance-Related Disorders | 1976 |
Clinical experiences with naltrexone in 370 detoxified addicts.
Topics: Clinical Trials as Topic; Cyclazocine; Drug Administration Schedule; Humans; Methadone; Naloxone; Naltrexone; Patient Compliance; Physicians; Placebos; Research Personnel; Substance-Related Disorders | 1976 |
Letter: Naloxone for diagnosis in methadone programs.
Topics: Clinical Trials as Topic; Heroin Dependence; Humans; Methadone; Naloxone; Personality Inventory; Substance Withdrawal Syndrome | 1975 |
The dysphoria of heroin addiction.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Mood Disorders; Naloxone; Psychiatric Status Rating Scales; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome | 1992 |
Acute effects of buprenorphine, hydromorphone and naloxone in methadone-maintained volunteers.
Topics: Adult; Buprenorphine; Cognition; Drug Interactions; Hemodynamics; Humans; Hydromorphone; Injections, Intramuscular; Male; Methadone; Naloxone; Psychomotor Performance; Substance Abuse Treatment Centers; Substance-Related Disorders | 1992 |
Phase II clinical trials of buprenorphine: detoxification and induction onto naltrexone.
Topics: Adult; Blood Pressure; Buprenorphine; Double-Blind Method; Female; Humans; Male; Methadone; Methoxyhydroxyphenylglycol; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1992 |
Acute physical dependence in humans: repeated naloxone-precipitated withdrawal after a single dose of methadone.
Topics: Adult; Arousal; Humans; Male; Methadone; Middle Aged; Naloxone; Neurologic Examination; Opioid-Related Disorders; Receptors, Opioid; Reflex, Pupillary; Substance Withdrawal Syndrome | 1991 |
Time course of naloxone-precipitated withdrawal after acute methadone exposure in humans.
Topics: Adult; Arousal; Humans; Injections, Intramuscular; Male; Metabolic Clearance Rate; Methadone; Naloxone; Neurologic Examination; Opioid-Related Disorders; Receptors, Opioid; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 1991 |
Clinical characteristics of naloxone-precipitated withdrawal in human opioid-dependent subjects.
Topics: Adult; Blood Pressure; Body Temperature; Cognition; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Male; Methadone; Middle Aged; Naloxone; Narcotics; Respiration; Substance Withdrawal Syndrome | 1992 |
Levels of opioid physical dependence in heroin addicts.
Topics: Adult; Drug Tolerance; Heroin; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Neurologic Examination; Substance Withdrawal Syndrome | 1991 |
Opioid antagonist challenges in buprenorphine maintained patients.
Topics: Administration, Sublingual; Adult; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infusions, Intravenous; Male; Methadone; Naloxone; Naltrexone; Substance Withdrawal Syndrome | 1990 |
Butorphanol-precipitated withdrawal in opioid-dependent human volunteers.
Topics: Adult; Butorphanol; Cognition; Double-Blind Method; Humans; Hydromorphone; Injections, Intramuscular; Male; Methadone; Morphinans; Naloxone; Opioid-Related Disorders; Psychomotor Performance; Substance Withdrawal Syndrome | 1988 |
Antagonist effects of nalbuphine in opioid-dependent human volunteers.
Topics: Adult; Dose-Response Relationship, Drug; Humans; Hydromorphone; Male; Methadone; Morphinans; Nalbuphine; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1989 |
Acute physical dependence in man: repeated naloxone-precipitated withdrawal after a single dose of methadone.
Topics: Double-Blind Method; Drug Administration Schedule; Humans; Methadone; Naloxone; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 1989 |
The effects of naloxone on opiate and placebo analgesia in healthy volunteers.
Topics: Adult; Analgesia; Analgesics, Opioid; Codeine; Endorphins; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Pain; Pain Management; Placebos | 1985 |
Clinical studies with naloxone/methadone in a ratio of 1:20.
Topics: Administration, Oral; Adult; Biological Availability; Clinical Trials as Topic; Dosage Forms; Drug Combinations; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Naloxone; Pupil; Rubber | 1973 |
Naloxone-methadone combination for the treatment of opiate dependence.
Topics: Administration, Oral; Adult; Chemistry, Clinical; Clinical Trials as Topic; Dosage Forms; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone | 1973 |
The role of narcotic antagonists in the rehabilitation of opiate addicts: a review of naltrexone.
Topics: Clinical Trials as Topic; Double-Blind Method; Endorphins; Humans; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Receptors, Opioid | 1980 |
Clinical utility of clonidine in opiate withdrawal: a study of 100 patients.
Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Humans; Methadone; Naloxone; Norepinephrine; Opioid-Related Disorders; Receptors, Adrenergic; Substance Withdrawal Syndrome | 1981 |
Naltrexone precipitated opiate withdrawal in methadone addicted human subjects: evidence for noradrenergic hyperactivity.
Topics: Adult; Blood Pressure; Brain; Female; Humans; Kinetics; Male; Methadone; Methoxyhydroxyphenylglycol; Naloxone; Naltrexone; Narcotics; Norepinephrine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Initial methadone dose in treating opiate addiction.
Topics: Dose-Response Relationship, Drug; Double-Blind Method; Humans; Methadone; Naloxone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1982 |
Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy.
Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1982 |
Operant analysis of human heroin self-administration and the effects of naltrexone.
Topics: Adult; Conditioning, Operant; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Placebos; Self Administration | 1981 |
Precipitated withdrawal by pentazocine in methadone-maintained volunteers.
Topics: Adult; Behavior; Humans; Hydromorphone; Male; Methadone; Naloxone; Pentazocine; Psychomotor Performance; Substance Withdrawal Syndrome; Time Factors | 1993 |
The opiate addiction test: a clinical evaluation of a quick test for physical dependence on opiate drugs.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Mydriasis; Naloxone; Narcotics; Pupil; Substance-Related Disorders | 1995 |
Opiate dependence and withdrawal: preliminary assessment using single photon emission computerized tomography (SPECT).
Topics: Adult; Analysis of Variance; Basal Ganglia; Blood Pressure; Brain; Cerebral Cortex; Double-Blind Method; Female; Gyrus Cinguli; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Thalamus; Tomography, Emission-Computed, Single-Photon | 1995 |
Gamma-hydroxybutyric acid for treatment of opiate withdrawal syndrome.
Topics: Adult; Double-Blind Method; Heroin Dependence; Humans; Male; Methadone; Naloxone; Sodium Oxybate; Substance Withdrawal Syndrome | 1993 |
Dose dependent effects of yohimbine on methadone maintained patients.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; In Vitro Techniques; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome; Substance-Related Disorders; Yohimbine | 1997 |
Buprenorphine and naloxone interactions in methadone maintenance patients.
Topics: Adult; Buprenorphine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anesthesia; Clonidine; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1998 |
Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure.
Topics: Acute Kidney Injury; Adult; Anesthesia; Codeine; Female; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Respiratory Insufficiency; Substance Withdrawal Syndrome; Thyroid Hormones | 1999 |
Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions.
Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Pupil; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Surveys and Questionnaires; Time Factors | 1999 |
Rapid opiate detoxication in outpatient treatment: relationship with naltrexone compliance.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; GABA Agents; Heroin Dependence; Humans; Inactivation, Metabolic; Ketoprofen; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Oxazepam; Patient Compliance; Substance Withdrawal Syndrome; Treatment Outcome | 2000 |
Acute detoxification of opioid-addicted patients with naloxone during propofol or methohexital anesthesia: a comparison of withdrawal symptoms, neuroendocrine, metabolic, and cardiovascular patterns.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Catecholamines; Female; Humans; Male; Methadone; Methohexital; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Propofol; Prospective Studies; Substance Withdrawal Syndrome | 2000 |
Transcutaneous iontophoresis of methadone provokes local flushing and thermal hyperalgesia.
Topics: Administration, Cutaneous; Adolescent; Adult; Female; Flushing; Hot Temperature; Humans; Hyperalgesia; Iontophoresis; Male; Methadone; Middle Aged; Naloxone; Pain; Pain Measurement; Regional Blood Flow; Skin | 2003 |
Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure.
Topics: Adult; Analysis of Variance; Blood Pressure; Dextromethorphan; Discrimination Learning; Dose-Response Relationship, Drug; Female; Humans; Isradipine; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders | 2004 |
Mu-opioid self-administration vs passive administration in heroin abusers produces differential EEG activation.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Electroencephalography; Female; Fentanyl; Heroin Dependence; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Psychiatric Status Rating Scales; Pupil; Receptors, Opioid, mu; Self Administration | 2005 |
Opioid craving and seeking behavior in physically dependent volunteers: effects of acute withdrawal and drug reinforcement opportunity.
Topics: Adult; Conditioning, Operant; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fentanyl; Heroin Dependence; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Psychiatric Status Rating Scales; Reinforcement, Psychology; Reward; Substance Withdrawal Syndrome; Surveys and Questionnaires | 2005 |
In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Clonidine; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Treatment Outcome | 2007 |
Patterns of nonfatal heroin overdose over a 3-year period: findings from the Australian treatment outcome study.
Topics: Adolescent; Adult; Buprenorphine; Cohort Studies; Drug Overdose; Episode of Care; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Incidence; Interviews as Topic; Male; Methadone; Middle Aged; Naloxone; Needle-Exchange Programs; New South Wales; Substance Abuse Treatment Centers; Treatment Outcome | 2007 |
A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial.
Topics: Adult; Behavior Therapy; Buprenorphine; Combined Modality Therapy; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Heroin; Heroin Dependence; Humans; Longitudinal Studies; Male; Methadone; Naloxone; Patient Compliance; Patient Dropouts; Severity of Illness Index; Single-Blind Method; Substance Abuse Detection; Treatment Outcome | 2007 |
Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone.
Topics: Administration, Sublingual; Adult; Buprenorphine; Cognition Disorders; Double-Blind Method; Drug Combinations; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Neuropsychological Tests; Opioid-Related Disorders; Psychomotor Disorders; Substance Withdrawal Syndrome | 2007 |
A history of sexual, emotional, or physical abuse predicts adjustment during opioid maintenance treatment.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Buprenorphine; Domestic Violence; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Psychiatric Status Rating Scales; Severity of Illness Index; Sex Factors; Sex Offenses; Social Adjustment; Time Factors; Treatment Outcome | 2008 |
Optimising the benefits of unobserved dose administration for stable opioid maintenance patients: follow-up of a randomised trial.
Topics: Adult; Australia; Buprenorphine; Directly Observed Therapy; Drug Administration Schedule; Drug Combinations; Female; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Patient Dropouts; Proportional Hazards Models; Secondary Prevention; Self Administration; Substance Abuse Treatment Centers; Treatment Outcome | 2008 |
Memory function in opioid-dependent patients treated with methadone or buprenorphine along with benzodiazepine: longitudinal change in comparison to healthy individuals.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Memory; Methadone; Naloxone; Opioid-Related Disorders; Substance-Related Disorders; Time Factors | 2009 |
The acceptability, safety, and tolerability of methadone/naloxone in a 50:1 ratio.
Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Heroin Dependence; Humans; Injections; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome | 2009 |
Improved HIV and substance abuse treatment outcomes for released HIV-infected prisoners: the impact of buprenorphine treatment.
Topics: Anti-Retroviral Agents; Buprenorphine; Buprenorphine, Naloxone Drug Combination; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Male; Mental Disorders; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Prisoners; Substance-Related Disorders | 2010 |
Pharmacokinetic interactions between darunavir/ritonavir and opioid maintenance therapy using methadone or buprenorphine/naloxone.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Darunavir; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Ritonavir; Sulfonamides | 2011 |
Lumbosacral spinal cord somatosensory evoked potentials for quantification of nociception in horses.
Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Cross-Over Studies; Evoked Potentials, Somatosensory; Horses; Lumbosacral Region; Methadone; Naloxone; Narcotic Antagonists; Pain Measurement; Spinal Cord | 2010 |
The BHIVES collaborative: organization and evaluation of a multisite demonstration of integrated buprenorphine/naloxone and HIV treatment.
Topics: Ambulatory Care; Buprenorphine; Buprenorphine, Naloxone Drug Combination; HIV Infections; Humans; Methadone; Multicenter Studies as Topic; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Pilot Projects; United States | 2011 |
Buprenorphine/naloxone versus methadone in opioid dependence: a longitudinal survey.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine; Drug Therapy, Combination; Educational Status; Female; Humans; Longitudinal Studies; Male; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Social Behavior | 2011 |
Medically assisted recovery from opiate dependence within the context of the UK drug strategy: methadone and Suboxone (buprenorphine-naloxone) patients compared.
Topics: Adult; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Follow-Up Studies; Health Policy; Heroin Dependence; Humans; Male; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Recurrence; Time Factors; Treatment Outcome; United Kingdom | 2013 |
Buprenorphine/Naloxone and methadone effects on laboratory indices of liver health: a randomized trial.
Topics: Adolescent; Adult; Buprenorphine; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Humans; Liver; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Transaminases; Treatment Outcome | 2013 |
A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction.
Topics: Administration, Sublingual; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Chronic Pain; Drug Combinations; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Prescription Drug Misuse; Severity of Illness Index; Substance Abuse Detection; Treatment Outcome | 2013 |
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure.
Topics: Adult; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Self Report; Substance Withdrawal Syndrome; Verapamil | 2013 |
An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans.
Topics: Adult; Analgesics, Opioid; Black or African American; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Genotype; Humans; Introns; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Polymorphism, Single Nucleotide; Receptors, Opioid, delta; Treatment Outcome; White People | 2013 |
Buprenorphine/naloxone and methadone maintenance treatment outcomes for opioid analgesic, heroin, and combined users: findings from starting treatment with agonist replacement therapies (START).
Topics: Adult; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Severity of Illness Index; Substance Abuse, Intravenous; Treatment Outcome; Young Adult | 2013 |
Treatment retention among patients randomized to buprenorphine/naloxone compared to methadone in a multi-site trial.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Male; Medication Adherence; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome; Young Adult | 2014 |
HIV risk reduction with buprenorphine-naloxone or methadone: findings from a randomized trial.
Topics: Adult; Buprenorphine; Female; HIV Infections; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Risk Reduction Behavior; Substance Abuse, Intravenous; Unsafe Sex | 2014 |
Opioid addicted buprenorphine injectors: drug use during and after 12-weeks of buprenorphine-naloxone or methadone in the Republic of Georgia.
Topics: Adult; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Counseling; Drug Users; Female; Georgia (Republic); Humans; Methadone; Middle Aged; Naloxone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Substance Abuse, Intravenous; Treatment Outcome | 2015 |
No Clinically Relevant Drug-Drug Interactions between Methadone or Buprenorphine-Naloxone and Antiviral Combination Glecaprevir and Pibrentasvir.
Topics: Adult; Aminoisobutyric Acids; Antiviral Agents; Benzimidazoles; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cyclopropanes; Drug Interactions; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Lactams, Macrocyclic; Leucine; Male; Methadone; Middle Aged; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Proline; Protease Inhibitors; Pyrrolidines; Quinoxalines; Sulfonamides; Surveys and Questionnaires; Young Adult | 2017 |
Comparison of Two Naloxone Regimens in Opioid-dependent Methadoneoverdosed Patients: A Clinical Trial Study.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Respiratory Insufficiency; Time Factors; Treatment Outcome; Young Adult | 2017 |
Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Respiratory Insufficiency; Young Adult | 2020 |
HIV clinic-based buprenorphine plus naloxone versus referral for methadone maintenance therapy for treatment of opioid use disorder in HIV clinics in Vietnam (BRAVO): an open-label, randomised, non-inferiority trial.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Buprenorphine; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Compliance; Random Allocation; RNA, Viral; Treatment Outcome; Vietnam; Viral Load | 2021 |
Buprenorphine/naloxone and methadone effectiveness for reducing craving in individuals with prescription opioid use disorder: Exploratory results from an open-label, pragmatic randomized controlled trial.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Craving; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Prescriptions | 2022 |
420 other study(ies) available for methadone and naloxone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands.
Topics: Animals; Cerebral Cortex; Combinatorial Chemistry Techniques; Humans; Imidazoles; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Radioligand Assay; Rats; Receptors, Opioid, mu; Solubility; Spiro Compounds; Structure-Activity Relationship | 2001 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Interactions between narcotic analgesics and benzodiazepine derivatives on behavior in the mouse.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzodiazepines; Brain; Brain Chemistry; Dextroamphetamine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Methadone; Methods; Mice; Morphine; Motor Activity; Naloxone; Oxazepam; Reaction Time | 1976 |
Behavioral effects of narcotic analgesics administered alone or in combination with narcotic antagonists.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Drug Interactions; Electroshock; Haplorhini; Macaca fascicularis; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors | 1976 |
Effects of narcotic analgesics on serotonin metabolism in brain of rats and mice.
Topics: Analgesics, Opioid; Animals; Atropine; Brain; Drug Interactions; Fenclonine; Hydroxyindoleacetic Acid; Male; Meperidine; Methadone; Mice; Mice, Inbred ICR; Morphine; Naloxone; Pargyline; Probenecid; Rats; Serotonin | 1976 |
Characterization of (+/-)-methadone uptake by rat lung.
Topics: Animals; Extracellular Space; Glucose; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetates; Lung; Male; Methadone; Morphine; Naloxone; Oxygen; Rats; Sodium; Spectrometry, Fluorescence; Stereoisomerism; Time Factors | 1977 |
Electric shock titration: effects of morphine, metadone, pentazocine, naloriphine, naloxone, diazepam and amphetamine.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dextroamphetamine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Haplorhini; Male; Methadone; Morphine; Naloxone; Narcotic Antagonists; Pentazocine; Saimiri | 1977 |
Pharmacotherapy of narcotic dependence.
Topics: Buprenorphine; Cyclazocine; Dextropropoxyphene; Diphenoxylate; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Pregnancy; Pregnancy Complications; Prognosis; Substance-Related Disorders | 1977 |
Some considerations regarding the characterization and interpretation of neuropeptide-induced behavioral changes.
Topics: Animals; Behavior, Animal; Benzimidazoles; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Haloperidol; Humans; Injections, Intravenous; Injections, Intraventricular; Methadone; Mice; Morphine; Motor Activity; Naloxone; Peptides; Rats; Time Factors | 1978 |
Comparison of opiate- and opioid-peptide-induced immobility.
Topics: Amygdala; Animals; Benzimidazoles; Brain; Caudate Nucleus; Endorphins; Enkephalins; Globus Pallidus; Injections; Injections, Intraventricular; Injections, Subcutaneous; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1979 |
Immunologic effects of morphine administration in rabbits.
Topics: Animals; Antibody Formation; Binding, Competitive; Carbon Radioisotopes; Carrier Proteins; Chemical Fractionation; Codeine; Cyclophosphamide; Drug Implants; Electrophoresis, Polyacrylamide Gel; Female; gamma-Globulins; Hemagglutination Tests; Hemocyanins; Heroin; Immunodiffusion; Levorphanol; Methadone; Morphine; Naloxone; Rabbits; Skin Tests | 1975 |
Letter: Treatment of accidental naltrexone-induced withdrawal.
Topics: Adult; Humans; Hydromorphone; Male; Methadone; Naloxone; Naltrexone; Substance Withdrawal Syndrome | 1976 |
The binding of the optical isomers of methadone, alpha-methadol, alpha-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain.
Topics: Animals; Brain; Dealkylation; Hydromorphone; In Vitro Techniques; Isomerism; Methadone; Methadyl Acetate; Naloxone; Rats; Receptors, Drug | 1976 |
Dependence in rats after one injection of heroin-, LAAM- or hydromorphone-zinc tannate.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Heroin; Heroin Dependence; Humans; Hydromorphone; Methadone; Methadyl Acetate; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1979 |
Naltrexone: the clinical investigator's dilemma.
Topics: Adolescent; Adult; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Patient Dropouts; Research Design; Social Adjustment; United States | 1978 |
Decrease in serum prolactin by naloxone: evidence against antidopamine and antipsychotic effects.
Topics: Animals; Haloperidol; Haplorhini; Humans; Macaca; Male; Methadone; Morphine; Naloxone; Opioid-Related Disorders; Prolactin; Psychotic Disorders; Receptors, Dopamine | 1979 |
Dual action of morphine and related drugs on compulsive gnawing of rats.
Topics: Animals; Apomorphine; Behavior, Animal; Compulsive Behavior; Female; Fenclonine; Humans; Meperidine; Methadone; Morphine; Naloxone; Rats; Serotonin; Stereotyped Behavior; Thalamic Nuclei | 1976 |
Role of 5-hydroxytryptamine in morphine-, pethidine-, and methadone-induced hypothermia in rats at low ambient and room temperature.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Cold Temperature; Depression, Chemical; Drug Interactions; Fenclonine; Male; Meperidine; Methadone; Morphine; Naloxone; Rats; Serotonin; Temperature; Time Factors | 1977 |
Changes in brain cyclic AMP metabolism and acetylcholine and dopamine during narcotic dependence and withdrawal.
Topics: Acetylcholine; Acetylcholinesterase; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Dopamine; Humans; Hypothalamus; Male; Mesencephalon; Methadone; Morphine; Naloxone; Protein Kinases; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Thalamus | 1975 |
The clinical usefulness of narcotic antagonists: implications of behavioral research.
Topics: Aftercare; Behavior Therapy; Conditioning, Operant; Cyclazocine; Extinction, Psychological; Heroin; Heroin Dependence; Hospitalization; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Patient Dropouts; Reinforcement, Psychology; Research Design; Self-Assessment | 1975 |
The effects of narcotic analgesics and narcotic antagonists on ganglionic transmission in the rat.
Topics: Animals; Ganglia, Autonomic; Levorphanol; Male; Meperidine; Methadone; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Stereoisomerism; Synaptic Transmission | 1976 |
The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists.
Topics: Allosteric Regulation; Dextropropoxyphene; Fentanyl; Methadone; Models, Biological; Models, Molecular; Molecular Conformation; Morphine; Nalorphine; Naloxone; Narcotics; Pentazocine; Phenazocine; Protein Conformation; Receptors, Opioid; Structure-Activity Relationship | 1976 |
Opioid peptides and opiates differ in receptor selectivity.
Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1977 |
Methadone maintenance and narcotic blocking drugs.
Topics: Aftercare; Cyclazocine; Extinction, Psychological; Heroin Dependence; Hospitalization; Humans; Levallorphan; Methadone; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Psychotherapy; Receptors, Opioid | 1977 |
Opiate properties of SKF 525A.
Topics: Analgesia; Animals; Injections, Intraventricular; Male; Methadone; Morphine; Naloxone; Narcotics; Proadifen; Rats; Reaction Time; Receptors, Opioid | 1978 |
An x-ray microanalysis study of differences in concentration of elements in brain cells due to opiates, cell type, and subcellular location.
Topics: Animals; Brain; Brain Chemistry; Calcium; Chlorides; Electron Probe Microanalysis; Ependyma; Female; Magnesium; Methadone; Microscopy, Electron, Scanning; Morphine; Naloxone; Neurons; Phosphorus; Potassium; Preoptic Area; Rats; Receptors, Opioid; Sodium; Subcellular Fractions; Sulfur | 1978 |
Endorphins, lithium, and naloxone: their relationship to pathological and drug-induced manic-euphoric states.
Topics: Adult; Amphetamine; Bipolar Disorder; Cocaine; Dopamine; Endorphins; Euphoria; Heroin Dependence; Humans; Lithium; Male; Methadone; Naloxone; Prolactin; Receptors, Opioid | 1978 |
Update of naltrexone treatment.
Topics: Adult; Conditioning, Psychological; Female; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotics; Receptors, Opioid; Social Adjustment; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Naltrexone in the treatment of opiate dependence.
Topics: Adolescent; Adult; Follow-Up Studies; Forecasting; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotics; New York City; Psychotherapy; Receptors, Opioid; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Spontaneous vs. naloxone-induced abstinence in dependent rats self-administering L-alpha-acetylmethadol (LAAM) or morphine.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine Dependence; Naloxone; Rats; Self Administration; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1979 |
Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone.
Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; Adult; Cyclic AMP; Electric Stimulation Therapy; Endorphins; Heroin Dependence; Humans; Hydrocortisone; Male; Methadone; Naloxone; Substance Withdrawal Syndrome | 1979 |
Dual action of methadone on 5-HT synthesis and metabolism.
Topics: 5-Hydroxytryptophan; Animals; Brain; Dihydroxyphenylalanine; Hydroxyindoleacetic Acid; Male; Methadone; Morphine; Naloxone; Probenecid; Rats; Serotonin; Tryptophan; Tyrosine | 1979 |
Effects of morphine, methadone, nalorphine and naloxone on responding under schedules of electric shock titration.
Topics: Analgesics; Animals; Avoidance Learning; Electroshock; Escape Reaction; Haplorhini; Male; Methadone; Morphine; Nalorphine; Naloxone; Punishment; Saimiri | 1977 |
The effect of opiates on endogenous phosphorylation of proteins in the synaptic plasma membranes of rat striatum.
Topics: Animals; Corpus Striatum; Drug Tolerance; Illicit Drugs; Male; Methadone; Morphine; Naloxone; Narcotics; Nerve Tissue Proteins; Phenytoin; Phosphorylation; Protein Kinases; Rats; Synaptic Membranes | 1979 |
Pharmacological effects and metabolic fate of levo-methadone during postnatal development in rat.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Blood Proteins; Brain; Methadone; Naloxone; Protein Binding; Rats; Subcellular Fractions; Tissue Distribution | 1979 |
Improved method for morphine extraction from biological samples.
Topics: Animals; Brain Chemistry; Chromatography, Thin Layer; Male; Methadone; Methods; Mice; Morphine; Naloxone | 1979 |
Increased serum methadone levels in humans during naloxone-precipitated withdrawal [proceedings].
Topics: Humans; Methadone; Naloxone; Substance Withdrawal Syndrome | 1979 |
Methadone binding at nonopiate receptor binding sites.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cattle; Caudate Nucleus; In Vitro Techniques; Membranes; Methadone; Naloxone; Narcotics; Osmolar Concentration; Rabbits; Stereoisomerism; Synaptosomes | 1979 |
Naloxone-precipitated jumping in mice pretreated with acute injections of opioids.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Enkephalins; Heroin; Male; Methadone; Methadyl Acetate; Mice; Morphine; Naloxone; Narcotics; Pentazocine | 1979 |
Effect of methadone and morphine on serotonin uptake in rat periaqueductal gray slices.
Topics: Animals; Brain; Cerebral Aqueduct; In Vitro Techniques; Male; Methadone; Morphine; Naloxone; Rats; Serotonin | 1979 |
Sustained release methadone salts and methadone-naloxone mixtures. Part 2: In vitro studies of methadone release.
Topics: Delayed-Action Preparations; Gastric Juice; Heroin Dependence; Humans; In Vitro Techniques; Methadone; Naloxone | 1977 |
Antidiuretic effect of morphine in the rat: tolerance and physical dependence.
Topics: Animals; Diuresis; Drug Implants; Drug Tolerance; Humans; Injections, Intraperitoneal; Methadone; Morphine; Morphine Dependence; Naloxone; Rats; Sodium Chloride; Time Factors; Water | 1978 |
Tolerance, dependence and lethality in morphine-dependent mice after repeated oral administration of methadone.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Implants; Humans; Male; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome | 1978 |
Development of cellular tolerance to lethality and analgesia concurrent with physical dependence following repeated oral administration of LAAM.
Topics: Administration, Oral; Animals; Drug Tolerance; Humans; Injections, Intraventricular; Lethal Dose 50; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred ICR; Morphine; Naloxone; Nociceptors; Opioid-Related Disorders | 1979 |
Comparing the effects of anileridine, alphaprodine and fentanyl on schedule-controlled responding by pigeons.
Topics: Alphaprodine; Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Fentanyl; Isonipecotic Acids; Male; Methadone; Morphine; Naloxone; Reinforcement Schedule | 1978 |
[Morphine intoxication and abstinence].
Topics: Dextropropoxyphene; Drug Tolerance; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome | 1977 |
Inhibition by d,l-methadone of RNA and protein synthesis in neonatal mice: antagonism by naloxone or naltrexone.
Topics: Animals; Animals, Newborn; Depression, Chemical; Liver; Methadone; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Protein Biosynthesis; RNA; Time Factors | 1978 |
Long acting methadone formulations.
Topics: Analgesics; Animals; Delayed-Action Preparations; Diffusion; Drug Combinations; Excipients; Male; Methadone; Naloxone; Rats; Suspensions; Time Factors | 1978 |
Comparison of immunogenicity of opiates bound to protein at different sites on the molecule: N-carboxy morphine-BSA.
Topics: Animals; Antibody Specificity; Binding Sites; Carrier Proteins; Codeine; Haptens; Heroin; Immune Sera; Immunologic Techniques; Levorphanol; Methadone; Morphine; Morphine Derivatives; Naloxone; Protein Binding; Rabbits; Rats; Serum Albumin, Bovine; Structure-Activity Relationship | 1976 |
Discrete-trial choice procedure: effects of naloxone and methadone on choice between food and heroin.
Topics: Animals; Choice Behavior; Decision Making; Feeding Behavior; Haplorhini; Heroin; Male; Methadone; Naloxone; Papio | 1975 |
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior | 1976 |
Evaluation of narcotic and narcotic antagonist interactions in primates.
Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration | 1976 |
Conditioned narcotic withdrawal in humans.
Topics: Adult; Conditioning, Classical; Humans; Male; Methadone; Naloxone; Substance Withdrawal Syndrome | 1977 |
Naloxone-precipitated withdrawal: a method for rapid induction onto naltrexone.
Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Methods; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1977 |
The safety and value of naloxone as a therapeutic aid.
Topics: Adolescent; Adult; Drug Evaluation; Heroin Dependence; Humans; Methadone; Middle Aged; Naloxone; Opium; Substance-Related Disorders | 1977 |
Meperidine effects on schedule-controlled responding.
Topics: Animals; Columbidae; Conditioning, Operant; Cyclazocine; Drug Interactions; Drug Tolerance; Male; Meperidine; Methadone; Morphine; Naloxone; Reaction Time; Reinforcement Schedule | 1977 |
Cardiac effects of 1-alpha-acetylmethadol. I. Chronotropic effects in vitro.
Topics: Animals; Drug Interactions; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Methacholine Compounds; Methadone; Methadyl Acetate; Morphine; Naloxone; Norepinephrine | 1977 |
Toxic interactions of stimulants, narcotics and narcotic antagonists.
Topics: Animals; Cocaine; Cyclazocine; Dextroamphetamine; Drug Synergism; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats | 1977 |
Naltrexone treatment of opiate-dependent persons.
Topics: Adult; Humans; Male; Methadone; Middle Aged; Naloxone; Naltrexone; Narcotics; Substance-Related Disorders | 1977 |
Inhibition of growth in young mice treated with d,1-methadone.
Topics: Animals; Animals, Newborn; Appetite Depressants; Body Weight; Depression, Chemical; Drug Tolerance; Female; Growth; Levallorphan; Methadone; Methadyl Acetate; Mice; Nalorphine; Naloxone; Reaction Time; Stereoisomerism; Time Factors | 1977 |
Methadone overdoses in a New York City hospital.
Topics: Adult; Emergency Service, Hospital; Female; Hospital Records; Humans; Liver; Male; Methadone; Muscles; Naloxone; Pulmonary Edema | 1976 |
Effects of acute and chronic methadone treatment of the uptake of 3H-5-hydroxytryptamine in rat hypothalamus slices.
Topics: Animals; Dextrorphan; Female; Heroin; Humans; Hypothalamus; In Vitro Techniques; Levorphanol; Methadone; Morphine; Naloxone; Rats; Serotonin; Substance Withdrawal Syndrome; Time Factors | 1976 |
Morphine: ability to block neuronal activity evoked by a nociceptive stimulus.
Topics: Action Potentials; Animals; Brain Stem; Chlorpromazine; Levorphanol; Male; Methadone; Morphine; Naloxone; Oxymorphone; Pain; Pentobarbital; Rats; Reticular Formation | 1976 |
Blockade of the specific lethal effects of narcotic analgesics in the mouse.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Methadone; Mice; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Oxazepam; Trimethadione | 1976 |
[Letter: Use of naloxone (Narcan) in poisoning by morphine, methadone and dextro propoxyphene].
Topics: Dextropropoxyphene; Humans; Methadone; Morphine; Naloxone; Poisoning; Suicide, Attempted | 1976 |
Alterations in brain endogenous histamine levels in rats after chronic morphine treatment and morphine withdrawal.
Topics: Animals; Body Weight; Brain; Brain Stem; Cerebral Cortex; Histamine; Humans; Male; Methadone; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Time Factors | 1976 |
Psychopathology and mood during heroin use: acute vs chronic effects.
Topics: Acute Disease; Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emotions; Euphoria; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Psychopathology | 1976 |
Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone diastereomers.
Topics: Analgesics; Animals; Drug Antagonism; Magnetic Resonance Spectroscopy; Male; Methadone; Mice; Models, Structural; Molecular Conformation; Naloxone; Stereoisomerism; Structure-Activity Relationship | 1976 |
An analysis of naltrexone use--its efficacy, safety and potential.
Topics: Adult; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Methadone; Middle Aged; MMPI; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Compliance; Patient Dropouts; Personality Inventory; Substance-Related Disorders | 1976 |
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1976 |
Naloxone therapy in a seven-month-old with methadone poisoning.
Topics: Humans; Infant; Male; Methadone; Naloxone; Poisoning | 1975 |
Treating heroin overdose.
Topics: Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Emergency Service, Hospital; Endocarditis; Female; Genital Diseases, Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infections; Male; Methadone; Naloxone; Pulmonary Edema; Respiratory Insufficiency | 1975 |
Ocular absorption of naloxone in narcotic addicts.
Topics: Absorption; Adolescent; Adult; Conjunctiva; Galvanic Skin Response; Humans; Injections, Intravenous; Methadone; Naloxone; Pupil; Substance Withdrawal Syndrome; Substance-Related Disorders; Sweating; Time Factors | 1975 |
Effects of narcotic antagonists on fluid intake in the rat.
Topics: Amphetamine; Animals; Cyclazocine; Feeding Behavior; Male; Methadone; Methyltyrosines; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Pentazocine; Rats | 1975 |
Mechanism of development of tolerance to injected morphine by guinea pig ileum.
Topics: Acetylcholine; Animals; Drug Tolerance; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Methadone; Morphine; Muscle Contraction; Naloxone; Norepinephrine; Receptors, Drug; Serotonin; Time Factors | 1975 |
Concurrent determination of narcotic drugs in plasm by gas-liquid chromatography.
Topics: Chromatography, Gas; Cocaine; Codeine; Cyclazocine; Humans; Levallorphan; Levorphanol; Methadone; Methods; Nalorphine; Naloxone; Narcotics; Pentazocine | 1975 |
Pharmacological approaches to the treatment of morphine-type dependence.
Topics: Cyclazocine; Drug Therapy, Combination; Drug Tolerance; Humans; Methadone; Morphine Dependence; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome | 1975 |
Blockade by narcotic drugs of naloxone-precipitated jumping in morphine-dependent mice.
Topics: Administration, Oral; Animals; Apomorphine; Behavior, Animal; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Injections, Intraperitoneal; Male; Meperidine; Methadone; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Narcotics; Pentazocine; Substance Withdrawal Syndrome | 1975 |
The offset of morphine tolerance in rats and mice.
Topics: Analgesics; Animals; Behavior, Animal; Drug Tolerance; Humans; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Rats; Time Factors | 1975 |
Possible role of brain histamine in morphine addiction.
Topics: Animals; Brain; Brain Stem; Cerebral Cortex; Histamine; Humans; Hypothalamus; Male; Methadone; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome | 1975 |
Comparative effects of opiate agonists methadone, levorphanol, and their isomers on the release of cortical ACh in vivo and in vitro.
Topics: Acetylcholine; Adrenal Cortex; Adrenal Glands; Animals; Dextrorphan; In Vitro Techniques; Levorphanol; Methadone; Naloxone; Rats; Stereoisomerism; Time Factors | 1975 |
Renal toxicity of l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Animals; Hematuria; Kidney Diseases; Kidney Tubules; Methadone; Methadyl Acetate; Morphine; Naloxone; Nephrosis; Phenobarbital; Rats; Time Factors | 1975 |
Experimental analysis of conditioning factors in human narcotic addiction.
Topics: Adult; Blood Pressure; Body Temperature; Conditioning, Operant; Humans; Male; Methadone; Motor Skills; Naloxone; Narcotics; Pulse; Respiration; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
On the role of chemotherapy in the treatment of heroin addiction.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Motivation; Naloxone; Naltrexone; Substance-Related Disorders | 1975 |
Clinical experience with naltrexone.
Topics: Administration, Oral; Adult; Female; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Dropouts; Placebos; Time Factors | 1975 |
Patient deaths in a narcotic antagonist (naltrexone) and l-alpha-acetylmethadol program.
Topics: Adult; Heroin Dependence; Homicide; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Naltrexone; Psychotropic Drugs; Substance-Related Disorders; Suicide | 1975 |
Stereotypy following acute administration of l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Amphetamine; Animals; Apomorphine; Behavior; Drug Interactions; Haloperidol; Humans; Male; Methadone; Methadyl Acetate; Methyltyrosines; Naloxone; Rats; Stereotyped Behavior | 1975 |
Effects of narcotic agonists and antagonists on schedule-induced water and morphine ingestion.
Topics: Animals; Cyclazocine; Drinking Behavior; Humans; Methadone; Morphine; Morphine Dependence; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Reinforcement Schedule | 1975 |
Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC.
Topics: Animals; Behavior, Animal; Cannabis; Dronabinol; Drug Tolerance; Humans; Male; Methadone; Morphine Dependence; Naloxone; Phytotherapy; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP) on ganglionic transmission.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Action Potentials; Animals; Electric Stimulation; Ganglia, Sympathetic; In Vitro Techniques; Male; Meperidine; Methadone; Morphine; Naloxone; Rats; Rats, Inbred Strains; Synaptic Transmission | 1992 |
Density of intrathecal agents.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Baclofen; Body Temperature; Cerebrospinal Fluid; Clonidine; Droperidol; Humans; Methadone; Midazolam; Naloxone; Specific Gravity; Temperature | 1992 |
Functional alterations of swine peripheral blood mononuclear cells by methadone.
Topics: Animals; Cytotoxicity, Immunologic; Endosomes; Killer Cells, Natural; Leukocytes, Mononuclear; Lysosomes; Membrane Fusion; Methadone; Naloxone; Phagocytosis; Phagosomes; Protein Biosynthesis; RNA; Superoxides; Swine; Tetradecanoylphorbol Acetate | 1992 |
Beta endorphin levels during heroin, methadone, buprenorphine, and naloxone challenges: preliminary findings.
Topics: Adult; beta-Endorphin; Buprenorphine; Female; Heroin; Humans; Male; Methadone; Middle Aged; Naloxone; Radioimmunoassay; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Morphine and methadone dependence in the rat: withdrawal and brain met-enkephalin levels.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Drinking; Enkephalin, Methionine; Female; Methadone; Morphine; Morphine Dependence; Naloxone; Radioimmunoassay; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Treatment of opioid-induced constipation with oral naloxone: a pilot study.
Topics: Adult; Constipation; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Oxycodone; Pilot Projects; Substance-Related Disorders | 1992 |
Discrimination of butorphanol and nalbuphine in opioid-dependent humans.
Topics: Adult; Behavior; Blood Pressure; Body Temperature; Butorphanol; Discrimination, Psychological; Generalization, Psychological; Humans; Hydromorphone; Male; Methadone; Middle Aged; Nalbuphine; Naloxone; Psychomotor Performance; Pupil; Receptors, Opioid | 1990 |
The effects of buprenorphine in methadone-dependent volunteers.
Topics: Buprenorphine; Double-Blind Method; Humans; Hydromorphone; Male; Methadone; Naloxone; Opioid-Related Disorders; Pupil | 1990 |
Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Fentanyl; Food; Male; Methadone; Morphine; Naloxone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 1991 |
Acute and chronic morphine administration: effects of mixed-action opioids in rats and squirrel monkeys responding under a schedule of food presentation.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Male; Methadone; Morphine; Nalorphine; Naloxone; Rats; Receptors, Opioid; Saimiri; Species Specificity | 1991 |
Outpatient comparison of buprenorphine and methadone maintenance. I. Effects on opiate use and self-reported adverse effects and withdrawal symptomatology.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Outpatients; Substance Withdrawal Syndrome | 1990 |
Similar efficacy of abrupt and gradual opiate detoxification.
Topics: Adult; Anesthesia, General; Female; Humans; Length of Stay; Male; Methadone; Methohexital; Naloxone; Neurologic Examination; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1991 |
Combined naloxone/methadone preparations for opiate substitution therapy.
Topics: Administration, Oral; Adult; Drug Combinations; Humans; Infusions, Intravenous; Methadone; Naloxone; Neurologic Examination; Opioid-Related Disorders; Substance Abuse, Intravenous; Substance Withdrawal Syndrome | 1991 |
Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates.
Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methadone; Midazolam; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1991 |
Unusual cause of methadone poisoning.
Topics: Amoxicillin; Drug Compounding; Female; Humans; Infant; Medication Errors; Methadone; Naloxone; Pharmacies; Poisoning | 1991 |
[Effect of buprenorphine on external pancreatic secretion in rats].
Topics: Animals; Buprenorphine; Deoxyglucose; Dose-Response Relationship, Drug; Male; Methadone; Naloxone; Pancreas; Rats; Rats, Inbred Strains | 1990 |
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
Effects of sublingually given naloxone in opioid-dependent human volunteers.
Topics: Administration, Sublingual; Adult; Arousal; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male; Methadone; Naloxone; Psychomotor Performance; Substance Withdrawal Syndrome | 1990 |
Three-choice drug discrimination in opioid-dependent humans: hydromorphone, naloxone and saline.
Topics: Adult; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Humans; Hydromorphone; Male; Methadone; Naloxone; Opioid-Related Disorders; Psychomotor Performance | 1987 |
Butorphanol-precipitated withdrawal in opioid-dependent human volunteers.
Topics: Butorphanol; Heart Rate; Humans; Hydromorphone; Male; Methadone; Morphinans; Naloxone; Opioid-Related Disorders; Pupil; Respiration; Skin Temperature; Substance Withdrawal Syndrome; Surveys and Questionnaires | 1987 |
Sublingual absorption of selected opioid analgesics.
Topics: Administration, Sublingual; Adult; Analgesics, Opioid; Analysis of Variance; Biological Availability; Buprenorphine; Fentanyl; Heroin; Humans; Hydromorphone; Levorphanol; Methadone; Morphine; Mouth; Naloxone; Oxycodone; Time Factors | 1988 |
Suppression of human peripheral blood mononuclear cell function by methadone and morphine.
Topics: Adult; Cells, Cultured; HIV Seropositivity; Humans; In Vitro Techniques; Interferon-gamma; Leukocytes, Mononuclear; Methadone; Middle Aged; Morphine; Naloxone; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys.
Topics: Animals; Behavior, Animal; Female; Macaca mulatta; Male; Methadone; Naloxone; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1989 |
Naloxone applied to conjunctiva as a test for physical opiate dependence.
Topics: Administration, Topical; Adult; Conjunctiva; Evaluation Studies as Topic; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Photography; Pupil; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors | 1989 |
New differences between the Wistar rat and Octodon degus, a putative laboratory animal resistant to morphine.
Topics: Adrenal Glands; Animals; Catecholamines; Drug Resistance; Electroencephalography; Ethanol; Female; Hemodynamics; In Vitro Techniques; Intestine, Small; Male; Methadone; Morphine; Naloxone; Rats; Rats, Inbred Strains; Respiration; Rodentia | 1989 |
Naloxone challenge as a biological predictor of treatment outcome in opiate addicts.
Topics: Arousal; Depressive Disorder; Humans; Methadone; Naloxone; Opioid-Related Disorders; Personality Tests; Prognosis; Psychiatric Status Rating Scales; Substance Withdrawal Syndrome | 1989 |
Use predicts treatment outcome, not opiate dependence or withdrawal.
Topics: Adult; Cocaine; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
Interaction of reinforcement history with methadone on responding maintained under a fixed-interval schedule.
Topics: Animals; Behavior, Animal; Columbidae; Dose-Response Relationship, Drug; Learning; Male; Methadone; Naloxone; Reinforcement, Psychology | 1989 |
Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria.
Topics: Adult; Female; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Psychiatric Status Rating Scales; Social Problems; Substance Withdrawal Syndrome | 1989 |
Evaluation of the effects of opioid agonists and antagonists under a delayed matching-to-sample procedure in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Columbidae; Cyclazocine; Discrimination Learning; Endorphins; Ethylketocyclazocine; Female; Methadone; Morphine; Naloxone; Phencyclidine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1987 |
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei | 1988 |
Plasma arginine vasopressin response to intravenous methadone and naloxone in conscious dogs.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Dogs; Female; Heart Rate; Injections, Intravenous; Male; Methadone; Morphine; Naloxone | 1989 |
Differentiating opioids by their pupillary effects in the rat.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Male; Methadone; Motor Activity; Naloxone; Narcotics; Nystagmus, Physiologic; Phenazocine; Pupil; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1985 |
The interference of naloxone hydrochloride in the teratogenic activity of opiates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Central Nervous System; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Female; Heroin; Methadone; Mice; Naloxone; Pregnancy; Receptors, Opioid | 1985 |
Opioid activity of lefetamine.
Topics: Anesthetics, Local; Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Methionine; Ethylketocyclazocine; Lethal Dose 50; Male; Methadone; Mice; Morphine; Naloxone; Phenethylamines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1985 |
Opioid-hallucinogen interactions.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hallucinogens; Liver; Lysergic Acid Diethylamide; Male; Methadone; Morphine; N,N-Dimethyltryptamine; Naloxone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism | 1986 |
Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Indicators and Reagents; Methadone; Mice; Morphine; N-Methylaspartate; Naloxone; Narcotics; Neurons; Stereoisomerism | 1988 |
Comparison of the effects of cocaine and d-amphetamine on the pharmacological actions of methadone.
Topics: Analgesia; Animals; Body Temperature; Cocaine; Dextroamphetamine; Drug Interactions; Male; Methadone; Mice; Naloxone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1987 |
Effects of buprenorphine, methadone and naloxone on acquisition of behavioral chains.
Topics: Animals; Behavior, Animal; Buprenorphine; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Learning; Male; Methadone; Naloxone | 1988 |
Mechanisms of the contractile responses to morphine of the mouse colon in vitro.
Topics: Animals; Colon; In Vitro Techniques; Methadone; Mice; Morphine; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Neostigmine; Serotonin Antagonists | 1988 |
[Cell-mediated immunity in drug addicts: interaction of opiates and naloxone on natural cytotoxic activity and immune-mediated reactions of phagocytes].
Topics: Adult; Chemotaxis, Leukocyte; Granulocytes; Heroin Dependence; Humans; Immunity, Cellular; Immunity, Innate; Marijuana Abuse; Methadone; Middle Aged; Monocytes; Naloxone; Narcotics; Substance-Related Disorders | 1988 |
Comparison of the discriminative stimulus properties of U50,488 and morphine in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Columbidae; Cyclazocine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Methadone; Morphine; Naloxone; Phenazocine; Phencyclidine; Pyrrolidines; Time Factors | 1987 |
Manitoba's methadone program: the first 15 years.
Topics: Acquired Immunodeficiency Syndrome; Humans; Manitoba; Methadone; Naloxone; Substance-Related Disorders | 1988 |
Assessment of opioid dependence with naloxone.
Topics: Adult; Female; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders | 1988 |
Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment.
Topics: Alprazolam; Analgesia; Animals; Ataxia; Cocaine; Drug Implants; Kinetics; Male; Methadone; Mice; Morphine; Naloxone; Narcotics | 1988 |
Ophthalmic naloxone elicits abstinence in opioid-dependent subjects.
Topics: Humans; Methadone; Naloxone; Ophthalmic Solutions; Opioid-Related Disorders; Pupil; Substance Withdrawal Syndrome; Time Factors | 1987 |
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule | 1987 |
Interaction of methadone, reinforcement history, and variable-interval performance.
Topics: Animals; Columbidae; Dose-Response Relationship, Drug; Male; Methadone; Naloxone; Reinforcement Schedule | 1987 |
[Drug therapy in overdose and withdrawal syndrome in heroin addicts].
Topics: Heroin; Heroin Dependence; Humans; Methadone; Naloxone; Psychotropic Drugs; Substance Withdrawal Syndrome | 1985 |
Dominantly inherited restless legs with myoclonus and periodic movements of sleep: a syndrome related to the endogenous opiates?
Topics: Aged; Dextropropoxyphene; Electrocardiography; Electroencephalography; Electrooculography; Endorphins; Female; Humans; Male; Methadone; Middle Aged; Myoclonus; Naloxone; Narcotics; Restless Legs Syndrome; Sleep Wake Disorders | 1986 |
Mydriatic response to topical naloxone in opiate abusers.
Topics: Adolescent; Adult; Dilatation; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Pupil | 1986 |
Safety of prolonged, high-dose infusion of naloxone hydrochloride for severe methadone overdose.
Topics: Adolescent; Blood Pressure; Female; Heart Rate; Humans; Infusions, Parenteral; Methadone; Naloxone; Respiration; Time Factors | 1986 |
Etorphine inhibition of pancreatic exocrine secretion in rats: comparison with methadone.
Topics: Anesthesia; Animals; Deoxyglucose; Diprenorphine; Electric Stimulation; Etorphine; Male; Methadone; Morphinans; Naloxone; Pancreas; Rats; Rats, Inbred Strains; Time Factors; Vagus Nerve | 1986 |
Effects of opioids and phencyclidine in combination with naltrexone on the acquisition and performance of response sequences in monkeys.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Erythrocebus patas; Female; Heroin; Methadone; Naloxone; Naltrexone; Narcotics; Phencyclidine; Reinforcement Schedule; Serial Learning | 1985 |
Effect of chronic methadone administration on neuroendocrine function in young adult rats.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endocrine Glands; Hormones; Humans; Male; Methadone; Naloxone; Neurosecretory Systems; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1985 |
Sensitivity of thin-layer chromatography for detection of 16 opioids, cocaine and quinine.
Topics: Alphaprodine; Chromatography, Thin Layer; Cocaine; Codeine; Cyclazocine; Dextropropoxyphene; Humans; Hydromorphone; Levallorphan; Levorphanol; Meperidine; Methadone; Methods; Morphinans; Morphine; Nalorphine; Naloxone; Oxymorphone; Pentazocine; Quinine | 1972 |
Stereospecific uptake of narcotic analgesics by a subcellular fraction of the guinea-pig ileum. A preliminary communication.
Topics: Analgesics; Animals; Codeine; Dextromoramide; Female; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Intestinal Absorption; Levorphanol; Male; Methadone; Morphine; Muscle, Smooth; Nalorphine; Naloxone; Narcotics; Subcellular Fractions; Tritium | 1973 |
Localization of narcotic analgesics in synaptic membranes of rat brain.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain; Cell Nucleus; Centrifugation, Density Gradient; Chromatography, Thin Layer; Hot Temperature; Levorphanol; Lipids; Male; Methadone; Microscopy, Electron; Microsomes; Mitochondria; Morphinans; Morphine Derivatives; Naloxone; Pentanols; Rats; Staining and Labeling; Stereoisomerism; Subcellular Fractions; Synaptic Membranes; Tritium | 1974 |
A comprehensive approach to the treatment of drug dependence.
Topics: Adolescent; Adult; Community Mental Health Services; Comprehensive Health Care; Connecticut; Counseling; Day Care, Medical; Health Education; Humans; Long-Term Care; Methadone; Naloxone; Patient Advocacy; Psychotherapy, Group; Schools, Medical; Substance-Related Disorders; Therapeutic Community; Vocational Education | 1974 |
Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.
Topics: Adenosine Triphosphate; Animals; Brain; Cyclic AMP; Heroin; In Vitro Techniques; Methadone; Morphinans; Morphine; Naloxone; Prostaglandin Antagonists; Rats; Tritium | 1974 |
Effects of acute and chronic adminstration of narcotic analgesics on growth hormone and corticotrophin (ACTH) secretion in rats.
Topics: Adrenocorticotropic Hormone; Animals; Dose-Response Relationship, Drug; Growth Hormone; Male; Methadone; Morphine; Nalorphine; Naloxone; Rats | 1973 |
Effects of opioid narcotic drugs on energy reserves of skeletal muscle. II. Further studies of the glycogenolytic action of methadone.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cyclic AMP; Dextropropoxyphene; Glycogen; In Vitro Techniques; Isomerism; Male; Methadone; Muscles; Naloxone; Phosphocreatine; Rats; Time Factors | 1974 |
A single-dose suppression test in morphine-dependent mice.
Topics: Aminopyrine; Analgesics; Animals; Behavior, Animal; Humans; Isonipecotic Acids; Levorphanol; Male; Methadone; Mice; Morphinans; Morphine; Morphine Dependence; Motor Activity; Nalorphine; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome | 1974 |
The increased efficacy of narcotic antagonists induced by various narcotic analgesics.
Topics: Analgesics; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Synergism; Levorphanol; Male; Methadone; Mice; Morphinans; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Reaction Time; Time Factors | 1974 |
Rating the presence and severity of opiate dependence.
Topics: Humans; Injections, Intramuscular; Methadone; Naloxone; Narcotics; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1974 |
Transport and interaction of drugs in leukocytes.
Topics: Amines; Amphetamine; Animals; Biological Transport, Active; Codeine; Drug Interactions; Fluorides; In Vitro Techniques; Kinetics; Leukocytes; Male; Methadone; Morphine; Naloxone; Pentazocine; Rats; Temperature; Time Factors | 1974 |
Effect of acutely administered analgesic drugs on rat brain serotonin turnover.
Topics: Analgesics; Animals; Brain; Brain Chemistry; Clomipramine; Dopamine; Hydroxyindoleacetic Acid; Kinetics; Male; Meperidine; Methadone; Morphine; Naloxone; Nialamide; Norepinephrine; Pargyline; Pentazocine; Rats; Serotonin; Stimulation, Chemical; Tranylcypromine; Tryptophan | 1974 |
Chromatographic detection of narcotic antagonists in human urine.
Topics: Analgesics; Chromatography; Chromatography, Gas; Chromatography, Thin Layer; Cyclazocine; Humans; Hydrogen-Ion Concentration; Methadone; Morphine; Naloxone; Narcotic Antagonists; Solvents; Temperature | 1974 |
Induction of physical dependence on morphine, codeine and meperidine in the rat by continuous infusion.
Topics: Animals; Behavior, Animal; Body Weight; Codeine; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Injections, Intraperitoneal; Male; Meperidine; Methadone; Morphine; Morphine Dependence; Nalorphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Vocalization, Animal | 1974 |
Naloxone reversal of methadone poisoning.
Topics: Adult; Child, Preschool; Female; Humans; Infant; Male; Methadone; Morphinans; Naloxone; Narcotic Antagonists; Poisoning | 1972 |
Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate.
Topics: Acetamides; Analgesics; Animals; Azides; Binding Sites; Binding, Competitive; Brain; Ethylmaleimide; Fluorides; In Vitro Techniques; Levorphanol; Male; Mercuribenzoates; Methadone; Morphinans; Morphine; Nalorphine; Naloxone; Pentanols; Phospholipases; Pronase; Prostaglandins; Rats; Receptors, Drug; Tritium; Trypsin | 1973 |
Modification of precipitated morphine and methadone abstinence in mice by acetylcholine antagonists.
Topics: Acetylcholine; Animals; Atropine; Drug Combinations; Humans; Mecamylamine; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1973 |
Plasma and urine levels of methadone. Comparison following four medication forms used in chronic maintenance treatment.
Topics: Adult; Chromatography, Gas; Drug Combinations; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Surveys and Questionnaires | 1973 |
Trophic functions of the neuron. VI. Other trophic systems. Inhibition of growth by methadone and other cholinolytic drugs.
Topics: Ambystoma; Animals; Animals, Newborn; Cell Differentiation; Choline; Depression, Chemical; Female; Growth; Hemicholinium 3; Larva; Levallorphan; Levorphanol; Male; Methadone; Mice; Mice, Inbred Strains; Naloxone; Parasympatholytics; Regeneration; Taste Buds | 1974 |
Studies on physical dependence inducible by hours exposure of mice to morphine.
Topics: Analgesia; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Humans; Infusions, Parenteral; Injections; Male; Meperidine; Methadone; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Pentazocine; Substance Withdrawal Syndrome; Time Factors | 1972 |
Effects of some narcotics and antagonists on synaptosomal 3 H-norepinephrine uptake.
Topics: Animals; Brain; Codeine; In Vitro Techniques; Methadone; Morphine; Nalorphine; Naloxone; Narcotics; Nerve Endings; Nerve Tissue Proteins; Norepinephrine; Pentobarbital; Pentylenetetrazole; Protein Binding; Rabbits; Synaptic Vesicles; Synaptosomes; Thebaine | 1972 |
Methadone in the management of heroin addiction.
Topics: Drug Tolerance; Heroin Dependence; Humans; Legislation, Drug; Methadone; Naloxone; United States | 1972 |
Treatment of propoxyphene overdosage with naloxone.
Topics: Adult; Coma; Dextropropoxyphene; Female; Humans; Infant; Methadone; Naloxone; Poisoning | 1973 |
Opiate receptor: demonstration in nervous tissue.
Topics: Analgesics; Animals; Atropine; Binding, Competitive; Brain; Carbachol; Codeine; Colchicine; Dextromethorphan; Dextropropoxyphene; Guinea Pigs; Histamine; Intestinal Mucosa; Levallorphan; Methadone; Mice; Morphine; Nalorphine; Naloxone; Phenazocine; Phenobarbital; Rats; Receptors, Drug; Serotonin; Tritium | 1973 |
Opiate antagonists and 'blockers'.
Topics: Cyclazocine; Humans; Levallorphan; Methadone; Nalorphine; Naloxone; Narcotic Antagonists; Substance-Related Disorders | 1973 |
Inhibition of neurotrophic activity in salamanders treated with opioids.
Topics: Animals; Hindlimb; Levallorphan; Levorphanol; Methadone; Mitosis; Naloxone; Nerve Regeneration; Taste Buds; Urodela | 1973 |
Two current poisonings: tricyclic drugs and methadone.
Topics: Anti-Arrhythmia Agents; Antidepressive Agents; Barbiturates; Catecholamines; Diuresis; Gastric Lavage; Humans; Methadone; Muscle Relaxants, Central; Nalorphine; Naloxone; Poisoning; Respiration, Artificial; Vasoconstrictor Agents; Ventricular Fibrillation | 1973 |
In vitro inhibitory effects of narcotic analgesics and other psychotropic drugs on the active uptake of norepinephrine in mouse brain tissue.
Topics: Animals; Atropine; Benztropine; Brain; Chlorpromazine; Cocaine; Codeine; Desipramine; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Levorphanol; Lipids; Meperidine; Methadone; Mice; Morphine; Naloxone; Narcotics; Norepinephrine; Solubility; Synaptosomes; Tritium | 1973 |
Agonistic properties of narcotic analgesics and antagonists on the electroencephalogram and behavior in the rat and their reversal by naloxone.
Topics: Analgesics; Animals; Behavior, Animal; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Female; Meperidine; Methadone; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Sleep; Time Factors | 1973 |
Growth retardation in young mice treated with d1-methadone.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Female; Growth; Injections, Subcutaneous; Male; Methadone; Mice; Naloxone | 1973 |
Naloxone for diagnosis in methadone programs.
Topics: Humans; Informed Consent; Injections, Intramuscular; Injections, Intravenous; Methadone; Nalorphine; Naloxone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1973 |
Methadone overdose treated with naloxone infusion.
Topics: Adolescent; Humans; Injections, Intravenous; Male; Methadone; Naloxone; Poisoning | 1973 |
The treatment of methadone poisoning with naloxone (Narcan).
Topics: Female; Humans; Infant; Medication Errors; Methadone; Naloxone; Poisoning | 1973 |
Effect of stimulus intensity on the potency of some analgetic agents.
Topics: Analgesics; Animals; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Levorphanol; Male; Meperidine; Methadone; Mice; Mice, Inbred Strains; Naloxone; Pentazocine; Physical Stimulation; Reaction Time; Seizures; Time Factors; Tremor | 1973 |
Treatment of overdose and withdrawal of abused drugs.
Topics: Amphetamine; Cathartics; Charcoal; Diuretics; Gastric Lavage; Hallucinogens; Humans; Hypnotics and Sedatives; Methadone; Naloxone; Opium; Parasympatholytics; Pulmonary Edema; Renal Dialysis; Respiration, Artificial; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents; Vomiting | 1973 |
Narcotic poisoning: an epidemic disease.
Topics: Diazepam; Glucose; Hospitalization; Humans; Hyperglycemia; Methadone; Myelitis, Transverse; Myoglobinuria; Naloxone; Narcotics; New York City; Pneumonia, Aspiration; Propranolol; Pulmonary Edema; Respiration; Substance Withdrawal Syndrome; Substance-Related Disorders; Tetanus Toxoid | 1973 |
Stereospecific interaction of opiate narcotics in binding of 3H-dihydromorphine to membranes of rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Corpus Striatum; Dextromethorphan; Kinetics; Levorphanol; Male; Methadone; Morphine; Naloxone; Protein Binding; Rats; Receptors, Drug; Synaptosomes; Tritium | 1973 |
Effects of narcotic analgesics and their antagonists on the rabbit isolated heart and its adrenergic nerves.
Topics: Animals; Autonomic Nervous System; Drug Interactions; Electric Stimulation; Female; Fentanyl; Heart; Heart Rate; In Vitro Techniques; Levallorphan; Male; Meperidine; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Norepinephrine; Perfusion; Rabbits; Secretory Rate; Sympathetic Nervous System | 1973 |
Insoluble salts and salt complexes of cyclazocine and naloxone.
Topics: Analgesics; Animals; Benzoates; Biopharmaceutics; Chemical Phenomena; Chemistry; Cyclazocine; Dosage Forms; Humans; Hydrogen-Ion Concentration; Methadone; Mice; Molecular Weight; Morphine; Naloxone; Salicylates; Salts; Spectrophotometry, Ultraviolet; Substance-Related Disorders; Suspensions; Tail; Tannins; Time Factors; Zinc | 1973 |
Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain.
Topics: Acetylcholine; Animals; Binding, Competitive; Brain Stem; Cerebral Cortex; Chloromercuribenzoates; Codeine; Dextromethorphan; Ethylmaleimide; Female; Heroin; In Vitro Techniques; Levorphanol; Methadone; Morphinans; Morphine; Nalorphine; Naloxone; Physostigmine; Rats; Receptors, Drug; Structure-Activity Relationship; Subcellular Fractions; Synaptic Membranes; Tritium | 1973 |
The oral absorption of methadone from a new parenterally nonabusable tablet.
Topics: Administration, Oral; Biological Availability; Drug Combinations; Heroin Dependence; Humans; Male; Methadone; Naloxone; Pharmaceutic Aids; Regression Analysis; Substance-Related Disorders | 1973 |
Naloxone for diagnosis of physical dependence in applicants to methadone programs.
Topics: Heroin Dependence; Humans; Injections, Intramuscular; Injections, Intravenous; Methadone; Naloxone; Substance Withdrawal Syndrome | 1973 |
Childhood methadone intoxication.
Topics: Administration, Oral; Boston; Child; Child, Preschool; Drug Packaging; Female; Heroin Dependence; Humans; Infant; Male; Methadone; Naloxone; Poisoning; Respiration | 1974 |
Methadone-naloxone mixtures for use in methadone maintenance programs. I. An evaluation in man of their pharmacological feasibility. II. Demonstration of acute physical dependence.
Topics: Drug Therapy, Combination; Filtration; Heroin Dependence; Humans; Male; Methadone; Morphine Dependence; Naloxone; Pupil; Time Factors | 1974 |
Studies on the use of XAD-2 resin for detection of abused drugs in urine.
Topics: Amobarbital; Amphetamine; Aspirin; Caffeine; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cocaine; Codeine; Evaluation Studies as Topic; Glucuronates; Humans; Hydrolysis; Meperidine; Meprobamate; Mescaline; Methadone; Methods; Microchemistry; Morphine; Nalorphine; Naloxone; Pentobarbital; Secobarbital; Substance-Related Disorders | 1974 |
Methadone inhibition of 3H-5-hydroxytryptamine uptake by synaptosomes.
Topics: Animals; Brain; Centrifugation, Density Gradient; Cold Temperature; Dinitrophenols; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Kinetics; Male; Methadone; Monoamine Oxidase Inhibitors; Morphine; Naloxone; Ouabain; Potassium Chloride; Rabbits; Serotonin; Serotonin Antagonists; Sucrose; Synaptosomes; Tritium | 1974 |
Some comparative effects of racemic methadone and its optical isomers in rodents.
Topics: Acetates; Administration, Oral; Analgesia; Animals; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Isomerism; Lethal Dose 50; Male; Methadone; Mice; Motor Activity; Naloxone; Optical Rotation; Rats; Reaction Time; Reflex; Spasm; Tail | 1974 |
Effect of naloxone on the analgesic activity of methadone in a 1:10 oral combination. Time and cost of flirting with the null hypothesis in tests of equivalence.
Topics: Adult; Analgesics; Analysis of Variance; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Methadone; Middle Aged; Naloxone; Pain, Postoperative; Sleep; Statistics as Topic; Time Factors | 1974 |
Alpha-1-acetylmethadol and its N-demethylated metabolites have potent opiate action in the guinea pig isolated ileum.
Topics: Acetates; Analgesics; Animals; Electric Stimulation; Guinea Pigs; Ileum; Methadone; Muscle, Smooth; Naloxone; Regression Analysis; Structure-Activity Relationship | 1974 |
Reciprocal (push-pull) effects of morphine on single units in the ventromedian and lateral hypothalamus and influences on other nuclei: with a comment on methadone effects during withdrawal from morphine.
Topics: Amygdala; Animals; Cerebral Cortex; Depression, Chemical; Drug Interactions; Electrophysiology; Humans; Hypothalamus; Methadone; Morphine; Morphine Dependence; Nalorphine; Naloxone; Neurons; Rats; Substance Withdrawal Syndrome; Time Factors | 1974 |
Catalepsy and stereotypies in rats treated with methadone; relation to striatal dopamine.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Catalepsy; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methadone; Naloxone; Norepinephrine; Rats; Reserpine; Serotonin; Stereotyped Behavior; Time Factors | 1974 |
Narcotic antagonists: the search accelerates.
Topics: Administration, Oral; Cyclazocine; Euphoria; Humans; Injections; Lactates; Methadone; Morphinans; Naloxone; Naphthalenes; Narcotic Antagonists; Polyethylenes; Polymers; Substance-Related Disorders | 1972 |
Drug scene in Alaska.
Topics: Alaska; Amphetamine; Cannabis; Community Health Services; Cyclazocine; Drug and Narcotic Control; Halfway Houses; Heroin; Humans; Methadone; Naloxone; Substance-Related Disorders | 1972 |
Morphine catalepsy in the rat: relation to striatal dopamine metabolism.
Topics: Animals; Apomorphine; Brain Chemistry; Catalepsy; Chlorpromazine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1972 |
Treatment of methadone poisoning.
Topics: Humans; Methadone; Naloxone; Poisoning | 1972 |
Blockade with methadone, cyclazocine, and naloxone.
Topics: Analgesics; Azocines; Cyclazocine; Evaluation Studies as Topic; Heroin; Hospitalization; Hospitals, General; Hospitals, Teaching; Humans; Methadone; Morphinans; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; New York City; Outpatient Clinics, Hospital; Psychotherapy; Substance Withdrawal Syndrome; Substance-Related Disorders | 1970 |
Three-choice discrimination in methadone maintenance patients: hydromorphone, naloxone, and saline.
Topics: Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Humans; Hydromorphone; Male; Methadone; Naloxone; Substance-Related Disorders | 1984 |
Clonidine hydrochloride detoxification from methadone treatment--the value of naltrexone aftercare.
Topics: Adult; Aftercare; Attitude to Health; Clonidine; Female; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1984 |
Involvement of endogenous opioid systems in social behavior of individually-housed mice.
Topics: Aggression; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Methadone; Mice; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Receptors, Opioid; Social Behavior; Social Isolation | 1984 |
Behavioral activating effects of opiates and opioid peptides.
Topics: Animals; Benzimidazoles; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Exploratory Behavior; Male; Methadone; Mice; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1980 |
Comparative cardiac contractile actions of six narcotic analgesics: morphine, meperidine, pentazocine, fentanyl, methadone and l-alpha-acetylmethadol (LAAM).
Topics: Analgesics, Opioid; Animals; Cats; Depression, Chemical; Drug Interactions; Fentanyl; Meperidine; Methadone; Methadyl Acetate; Morphine; Myocardial Contraction; Naloxone; Pentazocine; Stimulation, Chemical | 1980 |
Effects of narcotics and narcotic antagonists on affective disorders, schizophrenia and serum neurohormones.
Topics: Affective Disorders, Psychotic; Double-Blind Method; Endorphins; Humans; Hydrocortisone; Methadone; Motor Activity; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Prolactin; Random Allocation; Receptors, Opioid; Schizophrenia | 1981 |
Inhibition of ganglionic transmission by narcotic analgesics; an effect antagonized by naloxone, nalorphine and calcium.
Topics: Analgesics, Opioid; Animals; Calcium; Fentanyl; Ganglia, Sympathetic; Methadone; Morphine Derivatives; Nalorphine; Naloxone; Neural Inhibition; Oxycodone; Rana esculenta; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1981 |
Interaction of opiates with dopamine receptors: receptor binding and behavioral assays.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butaclamol; Dibenzocycloheptenes; Haloperidol; Kinetics; Male; Methadone; Morphine; Naloxone; Rats; Receptors, Dopamine; Spiperone | 1982 |
The effects of opiate agonists on growth hormone and prolactin release in rats.
Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate | 1980 |
An intracellular opiate receptor.
Topics: Adrenal Medulla; Animals; Catecholamines; Chromaffin Granules; Chromaffin System; Dextrorphan; Female; Methadone; Naloxone; Rats; Receptors, Opioid | 1980 |
Buprenorphrine: demonstration of physical dependence liability.
Topics: Animals; Buprenorphine; Drug Tolerance; Humans; Male; Methadone; Morphinans; Morphine; Naloxone; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
Central effects of morphine, levorphanol, (-)-methadone and the opioid-like peptides beta-endorphin and D-alanine2- methionine enkephalinamide on urine volume outflow and electrolytes.
Topics: Animals; beta-Endorphin; Brain; Diuresis; Electrolytes; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Levorphanol; Male; Methadone; Morphine; Naloxone; Narcotics; Rats; Vasopressins | 1981 |
Evidence for an endorphin dysfunction in methadone addicts: lack of ACTH response to naloxone.
Topics: Adrenocorticotropic Hormone; Endorphins; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1981 |
Non-neurogenic mechanism for reserpine-induced release of catecholamines from the adrenal medulla of neonatal rats: possible modulation by opiate receptors.
Topics: Adrenal Medulla; Animals; Catecholamines; Female; Male; Methadone; Naloxone; Pargyline; Rats; Rats, Inbred Strains; Receptors, Opioid; Reserpine; Splanchnic Nerves | 1982 |
Methadone-induced endorphin dysfunction in addicts.
Topics: Adrenocorticotropic Hormone; Brain; Endorphins; Humans; Hydrocortisone; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Receptors, Opioid; Substance Withdrawal Syndrome | 1982 |
A rapid and simple method for the quantitative determination of tolerance development to opiates in the guinea-pig ileum in vitro.
Topics: Animals; Binding, Competitive; Cyclic AMP; Drug Tolerance; Guinea Pigs; Humans; Ileum; Male; Methadone; Methods; Models, Biological; Morphine Derivatives; Muscle Contraction; Naloxone; Norepinephrine; Substance-Related Disorders | 1983 |
In utero exposure to methadone produces a stable decrease of the cortex 5-HT transport system in rats.
Topics: Animals; Biological Transport; Cerebral Cortex; Female; Imipramine; Methadone; Naloxone; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Muscarinic; Receptors, Serotonin; Serotonin; Synaptosomes | 1983 |
A comparison of antinociception induced by foot shock and morphine.
Topics: Animals; Cyclazocine; Electroshock; Foot; Male; Methadone; Morphine; Naloxone; Nociceptors; Pain; Pentazocine; Perception; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Time Factors | 1983 |
Effect of chronic naltrexone and methadone administration on brain immunoreactive beta-endorphin in the rat.
Topics: Animals; beta-Endorphin; Brain Chemistry; Endorphins; Hypothalamus; Male; Methadone; Naloxone; Naltrexone; Radioimmunoassay; Rats; Rats, Inbred Strains | 1983 |
Use of naltrexone to extinguish opioid-conditioned responses.
Topics: Adult; Combined Modality Therapy; Conditioning, Classical; Extinction, Psychological; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Recurrence; Relaxation Therapy | 1984 |
Various factors which affect the rate of development of tolerance and physical dependence to abused drugs.
Topics: Animals; Body Weight; Drug Tolerance; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Reaction Time; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1984 |
The index of choice: indications of methadone patients' selection of naltrexone treatment.
Topics: Adult; Attitude; Humans; Internal-External Control; Male; Methadone; Motivation; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Acceptance of Health Care; Prospective Studies; Self Concept; Social Environment | 1984 |
Strategies to improve compliance with narcotic antagonists.
Topics: Combined Modality Therapy; Humans; Life Style; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Patient Compliance; Patient Dropouts; Research; Social Support; Substance Withdrawal Syndrome | 1984 |
Continuous naloxone infusion for opiate poisoning in infancy.
Topics: Humans; Infant; Infant, Newborn; Infusions, Parenteral; Male; Meperidine; Methadone; Naloxone; Poisoning | 1984 |
The effect of methadone and naloxone on cultured rat liver cells.
Topics: Albumins; Animals; Cell Division; Cell Line; Cells, Cultured; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Methadone; Naloxone; Rats; Selenomethionine | 1984 |
Methadone and naltrexone in the treatment of heroin dependence.
Topics: Heroin Dependence; Humans; Methadone; Naloxone; Naltrexone; Psychotherapy; Substance Withdrawal Syndrome; Time Factors | 1984 |
Methadone induced physical dependence in the rat.
Topics: Animals; Behavior, Animal; Body Weight; Escape Reaction; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Rats; Rats, Inbred Strains; Self Stimulation; Substance-Related Disorders; Tremor | 1984 |
Endocrine effects of methadone in rats; acute effects in adults.
Topics: Aging; Animals; Corticosterone; Dose-Response Relationship, Drug; Female; Growth Hormone; Hormones; Male; Methadone; Morphine; Naloxone; Prolactin; Rats; Rats, Inbred Strains; Sex Factors; Thyrotropin | 1983 |
Effects of picenadol and its agonist and antagonist isomers on schedule-controlled behavior.
Topics: Animals; Behavior, Animal; Columbidae; Dose-Response Relationship, Drug; Isomerism; Male; Methadone; Naloxone; Narcotic Antagonists; Parasympatholytics; Piperidines; Structure-Activity Relationship | 1983 |
Rhabdomyolysis and acute myoglobinuric renal failure associated with methadone intoxication.
Topics: Acute Kidney Injury; Adult; Animals; Creatinine; Humans; Methadone; Naloxone; Rhabdomyolysis | 1983 |
Overall evaluation of treatment modalities for heroin addiction in a toxicology unit.
Topics: Clonidine; Heroin Dependence; Hospital Units; Humans; Methadone; Morphine; Naloxone; Narcotics; Outcome and Process Assessment, Health Care; Patient Dropouts; Substance Withdrawal Syndrome | 1983 |
Opiate withdrawal increases ornithine decarboxylase activity which is otherwise unaltered in brains of dependent chicken fetuses.
Topics: Animals; Brain; Carboxy-Lyases; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Ornithine Decarboxylase; Substance Withdrawal Syndrome | 1983 |
Naloxone-induced electrographic seizures in the primate.
Topics: Animals; Blood Pressure; Body Temperature; Drug Interactions; Electrocardiography; Electroencephalography; Female; Haplorhini; Macaca; Male; Methadone; Naloxone; Seizures; Time Factors | 1980 |
Clonidine hydrochloride detoxification from methadone treatments: the value of naltrexone aftercare.
Topics: Adolescent; Clonidine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Opium; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1981 |
Phencyclidine-induced stereotype in rats: effects of methadone, apomorphine, and naloxone.
Topics: Animals; Apomorphine; Brain Chemistry; Disease Models, Animal; Humans; Male; Methadone; Motor Activity; Naloxone; Phencyclidine; Psychoses, Substance-Induced; Rats; Rats, Inbred Strains; Stereotyped Behavior; Time Factors | 1981 |
Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat.
Topics: Animals; Conditioning, Operant; Drug Interactions; Drug Synergism; Lysergic Acid Diethylamide; Male; Methadone; Morphine; N,N-Dimethyltryptamine; Naloxone; Naltrexone; Narcotics; Rats; Reinforcement, Psychology; Tryptamines | 1981 |
Direct relationship of brain concentration of methadone with analgesia in chronic morphine-implanted and acute naloxone-treated rats.
Topics: Analgesia; Animals; Brain; Methadone; Morphine; Naloxone; Rats | 1982 |
Ontogeny of endocrine responses to methadone in rats.
Topics: Aging; Animals; Corticosterone; Growth Hormone; Kinetics; Methadone; Naloxone; Pituitary Hormones; Prolactin; Rats; Rats, Inbred Strains; Thyrotropin | 1983 |
The role of naloxone infusions in the treatment of overdoses of long half-life narcotic agonists: application to nor-methadone.
Topics: Apnea; Child, Preschool; Humans; Infusions, Parenteral; Male; Methadone; Naloxone | 1983 |
1983 perspectives on the pharmacotherapy of opiate addiction.
Topics: England; Humans; Methadone; Naloxone; Opioid-Related Disorders; Outcome and Process Assessment, Health Care; United States | 1983 |
The effect of morphine, methadone, and naloxone on taurine transport in human blood platelets.
Topics: Biological Transport, Active; Blood Platelets; Humans; Kinetics; Methadone; Morphine; Naloxone; Sodium; Spectrophotometry; Taurine | 1983 |
Postnatal abstinence or acute toxicity can account for morbidity in developmental studies with opiates.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Male; Methadone; Methadyl Acetate; Naloxone; Pregnancy; Rats; Rats, Inbred Strains | 1983 |
Methadone blocks dopamine-mediated release of gonadotropins in rat hypothalamus.
Topics: Animals; Dopamine; Gonadotropin-Releasing Hormone; Hypothalamus; Hypothalamus, Middle; In Vitro Techniques; Luteinizing Hormone; Male; Methadone; Naloxone; Pituitary Gland; Rats; Rats, Inbred Strains; Testosterone | 1982 |
Opioid and nonopioid behavioral effects of methadone isomers.
Topics: Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Drug Tolerance; Fentanyl; Kinetics; Male; Methadone; Naloxone; Pentobarbital; Stereoisomerism | 1982 |
The effects of morphine on calcium-regulated phosphorylation of synaptosomal cytosolic proteins from rat striatum.
Topics: Animals; Calcium; Corpus Striatum; Cytosol; In Vitro Techniques; Levorphanol; Male; Methadone; Morphine; Naloxone; Nerve Tissue Proteins; Phosphorylation; Rats; Stereoisomerism; Synaptosomes | 1982 |
Possible antidepressant activity of methadone.
Topics: Animals; Antidepressive Agents; Binding Sites; Cerebral Cortex; Imipramine; In Vitro Techniques; Membranes; Methadone; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Serotonin | 1982 |
The antinociceptive effects of epidural opiates in the cat: studies of the pharmacology and the effects of lipophilicity in spinal analgesia.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Epidural Space; Female; Fentanyl; Lipids; Male; Meperidine; Methadone; Morphine; Naloxone; Narcotics; Nociceptors; Pain; Reflex; Skin; Time Factors | 1982 |
[Medical aspects of opiate addiction].
Topics: Clonidine; Heroin Dependence; Humans; Inpatients; Methadone; Naloxone; Risk | 1982 |
Suppression of withdrawal jumping: comparison of narcotic tolerance and dependence.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Methadone; Mice; Mice, Inbred ICR; Morphine Dependence; Motor Activity; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1980 |
A method for determining cumulative behavioral toxicity after chronic oral administration of l-alpha-acetylmethadol to female rats.
Topics: Administration, Oral; Animals; Behavior, Animal; Drug Tolerance; Female; Fetus; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Substance-Related Disorders | 1980 |
Opiate withdrawal in utero increases neonatal morbidity in the rat.
Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; Methadyl Acetate; Naloxone; Opioid-Related Disorders; Pregnancy; Pregnancy, Animal; Rats; Substance Withdrawal Syndrome | 1981 |
Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
Topics: Animals; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1981 |
Withdrawal-like symptoms in young and adult rats maternally exposed to methadone.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Temperature Regulation; Body Weight; Female; Humans; Lactation; Male; Maternal-Fetal Exchange; Methadone; Naloxone; Nociceptors; Pregnancy; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1981 |
The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue.
Topics: Adipose Tissue; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fatty Acids, Nonesterified; Female; Humans; Lipolysis; Male; Methadone; Naloxone | 1981 |
Effect of methadone treatment during pregnancy on the fetal testes and hypothalamus in rats.
Topics: Androstenedione; Animals; Female; Fetal Blood; Fetus; Hypothalamus; Male; Methadone; Naloxone; Pregnancy; Pregnancy, Animal; Rats; Testis; Testosterone | 1980 |
The effects of levo-alpha-acetylmethadol and its metabolites on schedule-controlled behavior in the pigeon.
Topics: Animals; Behavior, Animal; Columbidae; Drug Tolerance; Methadone; Methadyl Acetate; Naloxone; Structure-Activity Relationship | 1981 |
Buprenorphine effects in methadone-maintained volunteers: effects at two hours after methadone.
Topics: Adult; Buprenorphine; Humans; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Psychomotor Performance; Pupil; Substance Withdrawal Syndrome | 1995 |
Accidental ingestion of methadone by children in Merseyside.
Topics: Accidents; Child; Child, Preschool; Drug Overdose; Emergencies; England; Female; Humans; Infant; Male; Methadone; Naloxone | 1994 |
Effects of the opioid antagonist naloxone on human natural killer cell activity in vitro.
Topics: Adult; Aged; Binding Sites; Case-Control Studies; Endorphins; Female; Heroin Dependence; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Male; Methadone; Middle Aged; Naloxone; Receptors, Opioid | 1994 |
Reliability of sequential naloxone challenge tests.
Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Humans; Injections, Intravenous; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Reproducibility of Results; Severity of Illness Index; Substance Withdrawal Syndrome; Substance-Related Disorders | 1995 |
Fatal methadone overdose.
Topics: Adult; Drug Overdose; Fatal Outcome; Humans; Male; Methadone; Naloxone | 1996 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
The induction and quantitation of methadone dependence in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Emulsions; Female; Methadone; Naloxone; Opioid-Related Disorders; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1996 |
Fatal methadone overdose. Naloxone infusion should have been started earlier.
Topics: Humans; Male; Methadone; Naloxone; Narcotic Antagonists | 1996 |
Fatal methadone overdose. Close observation in intensive care unit is required when naloxone infusion ends.
Topics: Critical Care; Drug Overdose; Humans; Male; Methadone; Naloxone; Narcotic Antagonists | 1996 |
[Opiate withdrawal in anesthesia (forced narcotic withdrawal, "turbo withdrawal") in narcotic dependence. Changes in withdrawal treatment--wishes and reality].
Topics: Adult; Anesthesia, General; Animals; Codeine; Female; Heroin Dependence; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Pilot Projects; Substance Withdrawal Syndrome; Treatment Outcome | 1996 |
d-Methadone is antinociceptive in the rat formalin test.
Topics: Analgesics, Opioid; Animals; Formaldehyde; Male; Methadone; N-Methylaspartate; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1997 |
Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts.
Topics: Adolescent; Adult; Animals; beta-Adrenergic Receptor Kinases; Brain; Cyclic AMP-Dependent Protein Kinases; Female; G-Protein-Coupled Receptor Kinase 2; Humans; Male; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1998 |
Opioid receptor agonists and antagonists alter GBR12909-induced turning in the rat.
Topics: Animals; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure.
Topics: Adult; Discrimination Learning; Dose-Response Relationship, Drug; Female; Humans; Hydromorphone; Male; Methadone; Naloxone; Opioid-Related Disorders | 1998 |
Kappa antinociceptive activity of spiradoline in the cold-water tail-flick assay in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Dose-Response Relationship, Drug; Drug Tolerance; Fentanyl; Male; Methadone; Naloxone; Narcotic Antagonists; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Stereoisomerism | 1998 |
Effects of diazepam, citalopram, methadone and naloxone on PCP-induced stereotyped behaviour and social isolation in the rat social interaction test.
Topics: Animals; Anti-Anxiety Agents; Citalopram; Diazepam; Drug Interactions; Hallucinogens; Interpersonal Relations; Male; Methadone; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Phencyclidine; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stereotyped Behavior | 1998 |
Orally delivered methadone as a reinforcer: Effects of the opioid antagonist naloxone.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Macaca mulatta; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Time Factors | 1999 |
The difference between methadone and morphine in regulation of delta-opioid receptors underlies the antagonistic effect of methadone on morphine-mediated cellular actions.
Topics: Adenylyl Cyclases; Alkaloids; Analgesics, Opioid; Animals; Benzophenanthridines; Colforsin; Cyclic AMP; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Hybrid Cells; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Phenanthridines; Protein Kinase C; Rats; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 1999 |
The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextropropoxyphene; DNA, Recombinant; Dose-Response Relationship, Drug; Electric Stimulation; Female; GTP-Binding Proteins; Ligands; Membrane Potentials; Methadone; Mice; Microinjections; Morphine; Naloxone; Oocytes; Patch-Clamp Techniques; Plasmids; Potassium Channels; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Complementary; Xenopus laevis | 1999 |
[Acute methadone poisoning].
Topics: Acute Disease; Adult; Depressive Disorder; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Poisoning; Suicide, Attempted | 2000 |
Neuronal inhibitory effects of methadone are predominantly opioid receptor mediated in the rat spinal cord in vivo.
Topics: Analgesics, Opioid; Animals; Electrophysiology; Male; Methadone; Naloxone; Narcotic Antagonists; Nerve Fibers; Nerve Fibers, Myelinated; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Stereoisomerism | 2000 |
Morphine and methadone have different effects on calcium channel currents in neuroblastoma cells.
Topics: Animals; Calcium Channels; Membrane Potentials; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Neurons; Patch-Clamp Techniques; Tumor Cells, Cultured | 2000 |
Managing constipation that's opioid-induced.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Constipation; Female; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds | 2000 |
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism.
Topics: Animals; Benzamides; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Response; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Methadone; N-Methylaspartate; Naloxone; Nociceptors; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Chronic mu-opioid receptor stimulation in humans decreases muscle sympathetic nerve activity.
Topics: Adult; Blood Pressure; Electrophysiology; Epinephrine; Female; Heart Rate; Humans; Male; Methadone; Muscles; Naloxone; Narcotic Antagonists; Narcotics; Norepinephrine; Opioid-Related Disorders; Peroneal Nerve; Receptors, Opioid, mu; Rest; Sympathetic Nervous System; Up-Regulation | 2001 |
[Evolution and update of detoxification techniques for opiate addicts].
Topics: Animals; Buprenorphine; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2000 |
Pediatric methodone poisoning revisted.
Topics: Child, Preschool; Humans; Infant; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics | 2001 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Intravenous bolus or infusion of naloxone in opioid overdose.
Topics: Adult; Antidotes; Drug Overdose; Evidence-Based Medicine; Heroin Dependence; Humans; Infusions, Intravenous; Male; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders | 2002 |
Methadone induces CCR5 and promotes AIDS virus infection.
Topics: Cell Line; Enzyme Activation; Gene Expression; Giant Cells; Humans; Lymphocytes; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Receptors, CCR5; Receptors, Opioid, mu; Retroviridae Infections; Retroviruses, Simian; RNA-Directed DNA Polymerase; RNA, Messenger; Simian Immunodeficiency Virus; Virus Replication | 2002 |
[Methadone poisoning in a 1-year-old child treated by continuous infusion of naloxone].
Topics: Accidents; Age Factors; Emergencies; Humans; Infant; Male; Methadone; Naloxone; Time Factors | 2002 |
Office-based treatment of opioid-dependent patients.
Topics: Buprenorphine; Drug and Narcotic Control; Drug Combinations; Drug Overdose; Family Practice; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Practice Patterns, Physicians'; United Kingdom | 2003 |
Nebulized naloxone gently and effectively reverses methadone intoxication.
Topics: Female; Humans; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Nebulizers and Vaporizers | 2003 |
[Opioid-related disorders].
Topics: Behavior Therapy; Buprenorphine; Diagnostic and Statistical Manual of Mental Disorders; Humans; International Classification of Diseases; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders | 2003 |
[Intoxication with methadone and benzodiazepines in a morbidly obese patient in the social environment of a heroin addict receiving methadone maintenance therapy].
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Blood Gas Analysis; Diazepam; Emergency Medical Services; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Obesity, Morbid; Social Environment | 2004 |
Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Buprenorphine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Limbic System; Male; Methadone; Naloxone; Nociceptin Receptor; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, Opioid; Receptors, Opioid, mu; Sex Factors; Sulfur Isotopes | 2004 |
[Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist or intubation?].
Topics: Analgesics, Opioid; Child, Preschool; Coma; Emergency Medical Services; Female; Humans; Intubation, Intratracheal; Methadone; Naloxone; Narcotic Antagonists; Oxygen Inhalation Therapy; Respiratory Insufficiency | 2004 |
Treating opiate addiction, Part I. Detoxification and maintenance.
Topics: Buprenorphine; Drug Combinations; Humans; Methadone; Naloxone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2004 |
Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Interactions; Female; Heroin; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Plethysmography, Whole Body; Quaternary Ammonium Compounds; Respiration; Respiratory Insufficiency; Substance Withdrawal Syndrome | 2006 |
Choice between heroin and food in nondependent and heroin-dependent rhesus monkeys: effects of naloxone, buprenorphine, and methadone.
Topics: Animals; Buprenorphine; Disease Models, Animal; Feeding Behavior; Heroin; Heroin Dependence; Macaca mulatta; Male; Methadone; Naloxone; Self Administration; Substance Withdrawal Syndrome | 2006 |
Slow tapering from methadone maintenance in a program encouraging indefinite maintenance.
Topics: Adult; Buprenorphine; Drug Administration Schedule; Female; Heroin Dependence; Humans; Male; Mental Health Services; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Program Development; Substance Withdrawal Syndrome | 2006 |
[Heroin substitution treatments. Analysis of current solutions, trends, and perspectives].
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Combinations; Humans; Methadone; Naloxone; Narcotics; Opioid-Related Disorders | 2006 |
Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion.
Topics: Accidents, Home; Animals; Brain Damage, Chronic; Child, Preschool; Diabetes Mellitus, Type 1; Diagnostic Errors; Dobutamine; Drug Packaging; Epinephrine; Female; France; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Infant; Insulin; Islets of Langerhans; Male; Methadone; Mice; Multiple Organ Failure; Myocardial Infarction; Naloxone; Receptor, Insulin; Receptors, Opioid, mu; Shock, Cardiogenic; Sweetening Agents; Time Factors | 2006 |
Emergency naloxone for heroin overdose: naloxone is not the only opioid antagonist.
Topics: Drug Overdose; Emergencies; Emergency Treatment; Heroin; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics | 2006 |
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Indophenol; Levorphanol; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Stereotyped Behavior; Tics; Tourette Syndrome; Tramadol; Triazoles | 2007 |
Onset of symptoms after methadone overdose.
Topics: Adolescent; Adult; Drug Overdose; Humans; Medical Records; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Poison Control Centers; Retrospective Studies; Time Factors | 2007 |
Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Infusions, Intravenous; Isomerism; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Poisoning; Respiration; Respiratory Insufficiency | 2007 |
[Pediatric methadone poisoning].
Topics: Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Poisoning | 2007 |
[Guidelines for acute detoxication and substitution treatment in persons unknown or only superficially known to the physician].
Topics: Buprenorphine; Drug Prescriptions; Humans; Inactivation, Metabolic; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Practice Guidelines as Topic; Prisons; Substance Withdrawal Syndrome | 2007 |
Obtundation in a toddler: naloxone is fundamental.
Topics: Child, Preschool; Drug Overdose; Emergency Medicine; Female; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Resuscitation | 2007 |
Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls.
Topics: Adult; Buprenorphine; Cognition; Cognition Disorders; Drug Therapy, Combination; Female; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Reaction Time | 2007 |
Colocating buprenorphine with methadone maintenance and outpatient chemical dependency services.
Topics: Adult; Ambulatory Care; Buprenorphine; Counseling; Delivery of Health Care, Integrated; Female; Health Services Accessibility; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Naloxone; Narcotics; New York City; Opioid-Related Disorders; Outcome Assessment, Health Care; Patient Care Team; Patient Dropouts; Social Work; Substance Abuse Detection | 2007 |
Acute respiratory distress syndrome induced by oral methadone managed with non-invasive ventilation.
Topics: Administration, Oral; Continuous Positive Airway Pressure; Drug Overdose; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Respiratory Distress Syndrome | 2007 |
Methadone-induced respiratory depression in the neonatal guinea pig.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Breath Tests; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Forced Expiratory Flow Rates; Guinea Pigs; Injections, Subcutaneous; Inspiratory Reserve Volume; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Oxygen Consumption; Plethysmography; Prognosis; Respiratory Insufficiency | 2007 |
Data do not support buprenorphine as a first-line treatment for addiction.
Topics: Buprenorphine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Heroin Dependence; Humans; Methadone; Naloxone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Treatment Outcome | 2007 |
Case files of the Drexel University Medical Toxicology Fellowship: methadone-induced QTc prolongation.
Topics: Adult; Drug Overdose; Electrocardiography; Emergency Medical Services; Humans; Long QT Syndrome; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Torsades de Pointes; Treatment Outcome | 2007 |
Buprenorphine + naloxone: new combination. Opiate dependence: no proof of reduced risk of self-administered injection.
Topics: Administration, Sublingual; Analgesics, Opioid; Buprenorphine; Drug Therapy, Combination; Finland; France; Heroin Dependence; Humans; Methadone; Morphine; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Patient Compliance; Patient Dropouts; Randomized Controlled Trials as Topic; Self Administration; Treatment Outcome | 2007 |
Onset of symptoms after methadone overdose.
Topics: Drug Overdose; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Time Factors | 2008 |
Methadone: does it really have low efficacy at micro-opioid receptors?
Topics: Animals; Animals, Newborn; Cell Line, Transformed; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Locus Coeruleus; Membrane Potentials; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Protein Binding; Rats; Receptors, Opioid, mu; Transfection | 2008 |
Chronic exposure of human macrophages in vitro to morphine and methadone induces a putative tolerant/dependent state.
Topics: Adolescent; Adult; Analysis of Variance; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; Macrophages; Male; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome; Time Factors | 2008 |
Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: a retrospective analysis.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Retrospective Studies; Sex Characteristics; Substance Withdrawal Syndrome | 2008 |
Methadone antinociception is dependent on peripheral opioid receptors.
Topics: Analgesics, Opioid; Animals; Drug Administration Routes; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Species Specificity | 2009 |
Preventing death among the recently incarcerated: an argument for naloxone prescription before release.
Topics: Analgesics, Opioid; Cocaine; Drug Overdose; Emergency Medical Services; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Patient Education as Topic; Prisoners; Rhode Island; Surveys and Questionnaires | 2009 |
Injection of medications used in opioid substitution treatment in Australia after the introduction of a mixed partial agonist-antagonist formulation.
Topics: Analgesics, Opioid; Buprenorphine; Drug Combinations; Female; Humans; Injections; Male; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Substance Abuse, Intravenous | 2009 |
[Guideline 'Medicinal care for drug addicts in penal institutions'].
Topics: Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Humans; Methadone; Naloxone; Netherlands; Practice Patterns, Physicians'; Prisoners; Substance Withdrawal Syndrome; Substance-Related Disorders | 2009 |
Prospective comparative assessment of buprenorphine overdose with heroin and methadone: clinical characteristics and response to antidotal treatment.
Topics: Adult; Antidotes; Buprenorphine; Drug Overdose; Female; Flumazenil; Heroin; Heroin Dependence; Humans; Intensive Care Units; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Prospective Studies; Suicide, Attempted | 2010 |
Treatment of acute pain in opioid tolerant patients.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Tolerance; Humans; Methadone; Naloxone; Opioid-Related Disorders; Pain; Pain Measurement | 2010 |
The diverse clinical uses of opioid receptor drugs.
Topics: Analgesics, Opioid; Buprenorphine; Drug Combinations; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists | 2010 |
The acceptability of combined methadone-naloxone treatment: Consumer and provider views on the potential utility of methadone-naloxone.
Topics: Adult; Attitude of Health Personnel; Communication; Drug Combinations; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Patient Acceptance of Health Care; Risk Assessment; Surveys and Questionnaires | 2010 |
Medical treatment of opioid dependence within the South African context.
Topics: Buprenorphine; Drug Combinations; Drug Overdose; Humans; Methadone; Motivation; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Recurrence; South Africa; Substance Withdrawal Syndrome | 2010 |
Factors associated with complicated buprenorphine inductions.
Topics: Adult; Benzodiazepines; Buprenorphine; Community Health Centers; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Retrospective Studies; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome; Urban Health Services | 2010 |
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestins; beta-Arrestins; Drug Tolerance; Fentanyl; Hot Temperature; Male; Methadone; Mice; Mice, Knockout; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, mu | 2011 |
Inhibitory action of methadone and its metabolites on erg-mediated K+ current in GH₃ pituitary tumor cells.
Topics: Animals; Cell Line, Tumor; Ether-A-Go-Go Potassium Channels; Methadone; Naloxone; Narcotics; Neurons; Pituitary Neoplasms; Prolactin; Pyrrolidines; Rats; Risperidone | 2011 |
The prevalence and correlates of buprenorphine inhalation amongst opioid substitution treatment (OST) clients in Australia.
Topics: Administration, Inhalation; Administration, Intranasal; Adult; Age Factors; Analgesics, Opioid; Australia; Behavior, Addictive; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cross-Sectional Studies; Drug Users; Female; Humans; Interviews as Topic; Logistic Models; Male; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Prevalence; Prisons; Product Surveillance, Postmarketing; Risk Assessment; Risk Factors; Smoking; Substance Abuse Treatment Centers | 2011 |
Participant characteristics and HIV risk behaviors among individuals entering integrated buprenorphine/naloxone and HIV care.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cross-Sectional Studies; Female; HIV Infections; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Needle Sharing; Odds Ratio; Opiate Substitution Treatment; Opioid-Related Disorders; Risk-Taking; Unsafe Sex | 2011 |
Prescribers' perceptions of the diversion and injection of medication by opioid substitution treatment patients.
Topics: Attitude of Health Personnel; Australia; Buprenorphine; Data Collection; Humans; Medication Adherence; Methadone; Naloxone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Perception; Pharmacists; Self Report | 2011 |
Project Lazarus: community-based overdose prevention in rural North Carolina.
Topics: Analgesics, Opioid; Drug Overdose; Humans; Methadone; Naloxone; Narcotic Antagonists; North Carolina; Patient Education as Topic; Prescription Drugs; Risk Factors; Rural Population; Social Welfare | 2011 |
Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Buprenorphine; Drug Interactions; Enzyme Activation; HEK293 Cells; Humans; Methadone; Naloxone; Nociceptin; Nociceptin Receptor; Opioid Peptides; Receptors, Opioid; Receptors, Opioid, mu | 2011 |
Combined liquid chromatography-coulometric detection and microextraction by packed sorbent for the plasma analysis of long acting opioids in heroin addicted patients.
Topics: Acetonitriles; Analgesics, Opioid; Buffers; Buprenorphine; Calibration; Chromatography, High Pressure Liquid; Electrochemical Techniques; Heroin Dependence; Humans; Limit of Detection; Methadone; Naloxone; Phosphates; Solid Phase Microextraction; Solvents | 2011 |
Transfer from high dose methadone to buprenorphine/naloxone.
Topics: Buprenorphine; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Practice Guidelines as Topic | 2011 |
Individual versus team-based case-management for clients of opioid treatment services: an initial evaluation of what clients prefer.
Topics: Adult; Buprenorphine; Case Management; Female; Health Care Surveys; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Patient Preference; Patient Satisfaction | 2012 |
Studying up harm reduction policy: the office as an assemblage.
Topics: Administrative Personnel; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug and Narcotic Control; Drug Users; Government Regulation; Harm Reduction; Health Policy; HIV Infections; Humans; Incidence; Methadone; Naloxone; Needle-Exchange Programs; Opiate Substitution Treatment; Policy Making; Private Sector; Qualitative Research; Social Behavior; Speech; Substance Abuse, Intravenous; Taiwan | 2011 |
Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Endocytosis; Gene Knock-In Techniques; Methadone; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Mutation; Naloxone; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders | 2012 |
Takotsubo cardiomyopathy due to iatrogenic methadone withdrawal.
Topics: Analgesics, Opioid; Coronary Angiography; Drug Overdose; Echocardiography; Electrocardiography; Humans; Iatrogenic Disease; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Takotsubo Cardiomyopathy | 2011 |
Use and misuse of opioid replacement therapies: a Queensland study.
Topics: Analgesics, Opioid; Buprenorphine; Drug Combinations; Harm Reduction; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Queensland; Retrospective Studies; Substance Abuse, Intravenous; Substance-Related Disorders | 2012 |
Financial factors and the implementation of medications for treating opioid use disorders.
Topics: Buprenorphine; Community Mental Health Centers; Criminal Law; Financing, Government; Health Plan Implementation; Health Workforce; Humans; Insurance Coverage; Medicaid; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Care Team; Substance Abuse Treatment Centers; United States | 2012 |
Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
Topics: Alprostadil; Biological Transport; Cadmium Chloride; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Lubiprostone; Methadone; Morphine; Naloxone; Patch-Clamp Techniques; Recombinant Proteins; Time Factors; Transfection | 2013 |
Early antidote use associated with noninvasive ventilation in prehospital treatment of methadone intoxication.
Topics: Analgesics, Opioid; Combined Modality Therapy; Drug Overdose; Emergency Medical Services; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Noninvasive Ventilation; Young Adult | 2013 |
Opioid overdose prevention with intranasal naloxone among people who take methadone.
Topics: Administration, Intranasal; Adult; Drug Overdose; Female; HIV Infections; Humans; Male; Massachusetts; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Education as Topic; Pilot Projects; Risk Factors; Substance Withdrawal Syndrome; Young Adult | 2013 |
Naloxone successfully counters life-threatening toxicity of benzodiazepine in a patient in methadone-maintenance treatment.
Topics: Benzodiazepines; Heroin Dependence; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neurotoxicity Syndromes; Young Adult | 2012 |
Opioid dependence.
Topics: Buprenorphine; Clonidine; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Prognosis; Risk Factors; Substance Withdrawal Syndrome; Time Factors | 2012 |
Treatment of addicts in Bosnia and Herzegovina--constraints and opportunities.
Topics: Adult; Analgesics, Opioid; Bosnia and Herzegovina; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Community Mental Health Centers; Humans; Mental Health Services; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome | 2012 |
Just call it "treatment".
Topics: Behavior, Addictive; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Counseling; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Substance-Related Disorders | 2012 |
Evaluation of the quality of life (Whoqol-Bref) among methadone and suboxone substitution state program patients and healthy volunteers in Georgia.
Topics: Adult; Aged; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Case-Control Studies; Female; Georgia (Republic); Government Programs; Humans; Male; Methadone; Middle Aged; Naloxone; Opiate Substitution Treatment; Quality of Life; Social Change; Surveys and Questionnaires; Young Adult | 2012 |
Needs assessment and treatment compliance at state opioid substitution treatment programes in Georgia.
Topics: Adult; Aged; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Georgia (Republic); Government Programs; Heroin Dependence; Humans; Hypnotics and Sedatives; Male; Marijuana Abuse; Methadone; Middle Aged; Naloxone; Needs Assessment; Opiate Substitution Treatment; Patient Compliance; Patient Satisfaction; Psychotherapy; Substance-Related Disorders; Surveys and Questionnaires; Young Adult | 2013 |
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord | 2013 |
Prescribing of drugs for attention-deficit hyperactivity disorder in opioid maintenance treatment patients in Norway.
Topics: Adolescent; Adult; Analgesics, Opioid; Attention Deficit Disorder with Hyperactivity; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Central Nervous System Stimulants; Databases, Factual; Female; Humans; Male; Methadone; Naloxone; Norway; Opiate Substitution Treatment; Opioid-Related Disorders; Prescription Drugs; Treatment Outcome; Young Adult | 2014 |
Acute respiratory distress syndrome caused by methadone syrup.
Topics: Administration, Oral; Adult; Coma; Drug Compounding; Drug Overdose; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Respiratory Distress Syndrome | 2013 |
Take-home naloxone kits preventing overdose deaths.
Topics: British Columbia; Drug Overdose; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics | 2014 |
Commentary on Hser et al. (2014): to retain or not to retain-open questions in opioid maintenance therapy.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Male; Medication Adherence; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders | 2014 |
The diversion and injection of a buprenorphine-naloxone soluble film formulation.
Topics: Administration, Sublingual; Adult; Australia; Buprenorphine; Chemistry, Pharmaceutical; Drug Costs; Female; Humans; Injections, Intravenous; Male; Methadone; Motivation; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Prescription Drug Diversion; Substance Abuse, Intravenous; Tablets; Treatment Outcome | 2014 |
Evaluation of state opioid substitution treatment program in Georgia.
Topics: Adult; Aged; Alcoholism; Buprenorphine; Female; Georgia (Republic); Government Programs; Hepatitis B; Hepatitis C; HIV Infections; Humans; Male; Methadone; Middle Aged; Naloxone; Opiate Substitution Treatment; Patient Compliance; Patient Satisfaction; Surveys and Questionnaires; Young Adult | 2014 |
Risk reduction with buprenorphine-naloxone and methadone: patient's choice.
Topics: Buprenorphine; Female; HIV Infections; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Risk Reduction Behavior | 2014 |
The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Heroin; Humans; Methadone; Naloxone; Naltrexone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Research Design; Systematic Reviews as Topic | 2014 |
Authors' reply: "Risk reduction with buprenorphine-naloxone and methadone: patient's choice".
Topics: Buprenorphine; Female; HIV Infections; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Risk Reduction Behavior | 2014 |
Reversal of opioid overdose syndrome in morphine-dependent rats using buprenorphine.
Topics: Animals; Buprenorphine; Drug Overdose; Male; Methadone; Morphine Dependence; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar | 2015 |
Failure to identify or effectively manage prescription opioid dependence acted as a gateway to heroin use-buprenorphine/naloxone treatment and recovery in a surgical patient.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Codeine; Disease Management; Female; Heroin; Heroin Dependence; Humans; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Pain, Postoperative; Substance Withdrawal Syndrome; Young Adult | 2014 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Retrospective Studies; Young Adult | 2015 |
A Retrospective Evaluation of Inpatient Transfer from High-Dose Methadone to Buprenorphine Substitution Therapy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Inpatients; Male; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Outcome Assessment, Health Care | 2015 |
Accidental methadone intoxication masquerading as asthma exacerbation with respiratory arrest in a six-year-old boy.
Topics: Asthma; Bradycardia; Child; Diagnosis, Differential; Drug Overdose; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Respiratory Insufficiency | 2015 |
Harm Reduction: Front Line Public Health.
Topics: Buprenorphine; Drug Overdose; Harm Reduction; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Needle-Exchange Programs; Public Health; Substance-Related Disorders | 2015 |
Management of opioid-dependent patients: comparison of the cost associated with use of buprenorphine/naloxone or methadone, and their interactions with concomitant treatments for infectious or psychiatric comorbidities.
Topics: Analgesics, Opioid; Buprenorphine; Drug Interactions; Health Care Costs; Humans; Infections; Mental Disorders; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders | 2015 |
Opioid-induced constipation reversal in response to placebo in a patient with a history of IBS receiving methadone maintenance therapy.
Topics: Analgesics, Opioid; Constipation; Cross-Over Studies; Female; Humans; Irritable Bowel Syndrome; Laxatives; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Patient Satisfaction; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome | 2015 |
Total Joint Arthroplasty in Patients Taking Methadone or Buprenorphine/Naloxone Preoperatively for Prior Heroin Addiction: A Prospective Matched Cohort Study.
Topics: Aged; Arthroplasty, Replacement; Buprenorphine; Cohort Studies; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Narcotics; Pain Management; Pain, Postoperative; Prospective Studies; Registries; Retrospective Studies; Treatment Outcome | 2016 |
Simultaneous quantification of buprenorphine, naloxone and phase I and II metabolites in plasma and breastmilk by liquid chromatography-tandem mass spectrometry.
Topics: Buprenorphine; Chromatography, Liquid; Female; Glucuronides; Humans; Infant, Newborn; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Methadone; Milk, Human; Naloxone; Narcotic Antagonists; Pregnancy; Solid Phase Extraction; Tandem Mass Spectrometry | 2016 |
Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder.
Topics: Adult; Buprenorphine; Chronic Pain; Comorbidity; Cross-Sectional Studies; Disability Evaluation; Female; Heroin Dependence; HIV Seropositivity; Humans; Illicit Drugs; Male; Mental Disorders; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Pain Measurement; Prescription Drugs; Young Adult | 2016 |
Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex.
Topics: Animals; Caspase 3; Caspase 7; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Human Growth Hormone; L-Lactate Dehydrogenase; Methadone; Mitochondria; Morphine; Naloxone; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger | 2016 |
Intravenous Buprenorphine: A Substitute for Naloxone in Methadone-Overdosed Patients?
Topics: Administration, Intravenous; Buprenorphine; Drug Overdose; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Respiratory Insufficiency; Treatment Outcome; Young Adult | 2017 |
Infants Born to Opioid-Dependent Women in Ontario, 2002-2014.
Topics: Adult; Buprenorphine; Congenital Abnormalities; Databases, Factual; Female; Health Care Costs; Humans; Infant; Infant Mortality; Infant, Newborn; Length of Stay; Male; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neonatal Abstinence Syndrome; Ontario; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Stillbirth; Young Adult | 2017 |
Suspected Methadone Toxicity: from Hospital to Autopsy Bed.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Autopsy; Blood Gas Analysis; Cause of Death; Child; Child, Preschool; Drug Overdose; Female; Hospitals; Humans; Infant; Italy; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Retrospective Studies; Sex Factors; Treatment Outcome; Young Adult | 2017 |
Risk factors for severe respiratory depression from prescription opioid overdose.
Topics: Adult; Age Factors; Analgesics, Opioid; Cohort Studies; Drug Overdose; Emergency Service, Hospital; Female; Fentanyl; Humans; Intubation, Intratracheal; Male; Methadone; Middle Aged; Multivariate Analysis; Naloxone; Narcotic Antagonists; Odds Ratio; Oxycodone; Prescription Drug Misuse; Prospective Studies; Respiration, Artificial; Respiratory Insufficiency; Risk Factors; Severity of Illness Index; United States | 2018 |
A case report of methadone-associated hypoglycemia in an 11-month-old male.
Topics: Humans; Hypoglycemia; Infant; Male; Methadone; Naloxone | 2018 |
Oxford House Residents' Attitudes Toward Medication Assisted Treatment Use in Fellow Residents.
Topics: Analgesics, Opioid; Analysis of Variance; Attitude to Health; Buprenorphine; Cross-Sectional Studies; Drug Utilization; Female; Halfway Houses; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Outpatients; Surveys and Questionnaires | 2018 |
Physician prescribing of opioid agonist treatments in provincial correctional facilities in Ontario, Canada: A survey.
Topics: Adult; Buprenorphine; Humans; Male; Methadone; Naloxone; Ontario; Opiate Substitution Treatment; Opioid-Related Disorders; Practice Patterns, Physicians'; Prisons; Surveys and Questionnaires | 2018 |
Disulfiram attenuates morphine or methadone withdrawal syndrome in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disulfiram; Male; Methadone; Mice; Mice, Inbred C57BL; Models, Animal; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2018 |
Readiness and recovery: Transferring between methadone and buprenorphine/naloxone for the treatment of opioid use disorder.
Topics: Adult; Aged; Buprenorphine; Drug Substitution; Female; Humans; Interviews as Topic; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Preference | 2019 |
Reversal of Pediatric Opioid Toxicity with Take-Home Naloxone: a Case Report.
Topics: Administration, Intranasal; Analgesics, Opioid; Drug Overdose; Female; Home Care Services; Humans; Infant; Methadone; Naloxone; Narcotic Antagonists | 2019 |
Overdose mortality rates in Croatia and factors associated with self-reported drug overdose among persons who inject drugs in three Croatian cities.
Topics: Adult; Buprenorphine; Croatia; Cross-Sectional Studies; Drug Overdose; Female; Harm Reduction; Humans; Male; Methadone; Middle Aged; Mortality; Naloxone; Opiate Substitution Treatment; Self Report; Substance Abuse, Intravenous; Surveys and Questionnaires | 2019 |
Comparing Canadian and United States opioid agonist therapy policies.
Topics: Buprenorphine; Canada; Drug Overdose; Health Policy; Humans; Insurance Coverage; Methadone; Naloxone; Opiate Substitution Treatment; Opioid Epidemic; Opioid-Related Disorders; United States | 2019 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
Placental trophoblast transfer of opioids following exposures to individual or mixtures of opioids
Topics: Analgesics, Opioid; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Maternal-Fetal Exchange; Methadone; Morphine; Naloxone; Oxycodone; Placenta; Pregnancy; Trophoblasts | 2019 |
A national survey of approaches to manage the ICU patient with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Critical Care; Critical Illness; Hospitalization; Hospitals; Humans; Hypnotics and Sedatives; Intensive Care Units; Methadone; Naloxone; Opioid-Related Disorders; Outpatients; Practice Guidelines as Topic; Surveys and Questionnaires; United States | 2019 |
Patient perceptions of treatment with medication treatment for opioid use disorder (MOUD) in the Vermont hub-and-spoke system.
Topics: Adult; Aged; Aged, 80 and over; Buprenorphine; Female; Health Services Accessibility; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Satisfaction; Vermont; Young Adult | 2019 |
Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids.
Topics: Adolescent; Adult; Analgesics, Opioid; Australia; Chronic Pain; Drug Overdose; Drug Prescriptions; Female; Fentanyl; Heroin; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Opioid-Related Disorders; Tramadol; Young Adult | 2019 |
The cascade of care for opioid use disorder: a retrospective study in British Columbia, Canada.
Topics: Adult; Analgesics, Opioid; British Columbia; Buprenorphine; Female; Hepatitis C; Humans; Ill-Housed Persons; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Retrospective Studies; Young Adult | 2020 |
Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study.
Topics: Adolescent; Adult; British Columbia; Buprenorphine; Cause of Death; Cohort Studies; Emergencies; Female; Fentanyl; Humans; Illicit Drugs; Male; Methadone; Middle Aged; Mortality; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Public Health; Retrospective Studies; Risk Assessment; Young Adult | 2020 |
The psychiatrist at the centre of the opioid crisis.
Topics: Alcoholism; Cocaine-Related Disorders; Dopamine; Drug Overdose; Heroin Dependence; History, 20th Century; History, 21st Century; Humans; Marijuana Abuse; Methadone; Methamphetamine; Naloxone; National Institutes of Health (U.S.); Neurosciences; Opioid-Related Disorders; Positron-Emission Tomography; Prefrontal Cortex; Psychiatry; Reward; Socioeconomic Factors; United States | 2020 |
Naloxone should remain the appropriate antidote to treat opioid overdose.
Topics: Analgesics, Opioid; Antidotes; Buprenorphine; Drug Overdose; Humans; Methadone; Naloxone; Prospective Studies; Respiratory Insufficiency | 2020 |
Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Coma; Drug Overdose; Female; Hospital Mortality; Hospitalization; Humans; Infant; Male; Methadone; Middle Aged; Naloxone; Registries; Respiratory Insufficiency; United States; Young Adult | 2020 |
Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse.
Topics: Analgesics, Opioid; Ascorbic Acid; Dehydroascorbic Acid; Enkephalin, Methionine; Glutathione; Humans; Hydromorphone; Methadone; Morphine; Naloxone; Peptides; Receptors, Adrenergic, beta-2; Receptors, Dopamine D1; Receptors, Histamine H1; Receptors, Opioid; Receptors, Opioid, mu | 2020 |
Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block.
Topics: Buprenorphine; Electrocardiography; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Channel Gating; Methadone; Myocytes, Cardiac; Naloxone; Naltrexone; Potassium Channel Blockers; Receptors, Opioid; Time Factors | 2020 |
Harm reduction in the time of COVID-19: Case study of homelessness and drug use in Dublin, Ireland.
Topics: Benzodiazepines; COVID-19; Harm Reduction; Health Policy; Housing; Humans; Ill-Housed Persons; Ireland; Methadone; Naloxone; Substance-Related Disorders | 2021 |
A study of the effectiveness of naltrexone in preventing recurrence of methadone poisoning in opioid-naive children.
Topics: Adolescent; Aftercare; Analgesics, Opioid; Child; Child, Preschool; Female; Hospitalization; Humans; Infant; Intensive Care Units; Iran; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neoplasms; Patient Discharge; Poisoning; Recurrence; Retrospective Studies | 2021 |
Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent.
Topics: Analgesics, Opioid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Glioblastoma; Humans; Methadone; Morphine; Naloxone; Oxycodone; Receptors, Opioid, mu; Tumor Cells, Cultured | 2021 |
Imperfect progress: treatment options for opioid dependence.
Topics: Buprenorphine; HIV Infections; Humans; Maintenance; Methadone; Naloxone; Nitriles; Opioid-Related Disorders; Referral and Consultation; Vietnam | 2021 |
Impacts of the COVID-19 pandemic on healthcare access among patients receiving medication for opioid use disorder.
Topics: Adult; Buprenorphine; Clinical Trials as Topic; COVID-19; Cross-Sectional Studies; Female; Harm Reduction; Health Services Accessibility; Humans; Latent Class Analysis; Male; Methadone; Naloxone; New England; Opiate Substitution Treatment; Substance-Related Disorders | 2021 |
Cost-effectiveness of Treatments for Opioid Use Disorder.
Topics: Adult; Buprenorphine; Combined Modality Therapy; Cost-Benefit Analysis; Delayed-Action Preparations; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Opiate Overdose; Opiate Substitution Treatment; Opioid-Related Disorders; Psychotherapy; Treatment Outcome | 2021 |
Opioid Use Disorder and Perinatal Outcomes.
Topics: Adult; Analgesics, Opioid; British Columbia; Buprenorphine; Female; Humans; Incidence; Infant, Newborn; Logistic Models; Longitudinal Studies; Methadone; Naloxone; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth; Retrospective Studies | 2021 |
Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers.
Topics: Analgesics, Opioid; Animals; Apoptosis; Biomarkers; Cell Line; Cyclic AMP; Glial Cell Line-Derived Neurotrophic Factor; Inflammation; Male; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxidative Stress; Oxidoreductases; Proto-Oncogene Proteins c-bcl-2; Sertoli Cells; Substance Withdrawal Syndrome | 2021 |
Perioperative Management of Buprenorphine/Naloxone in a Large, National Health Care System: a Retrospective Cohort Study.
Topics: Analgesics, Opioid; Buprenorphine; Delivery of Health Care; Humans; Male; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Retrospective Studies | 2022 |
Harm Reduction for Patients With Substance Use Disorders.
Topics: Adult; Buprenorphine; Contraception; Drug Overdose; Female; Harm Reduction; Heroin; Humans; Male; Methadone; Methamphetamine; Naloxone; Opioid-Related Disorders; Pregnancy; Quality of Life; Referral and Consultation; Substance-Related Disorders | 2022 |
Association Between Increased Dispensing of Opioid Agonist Therapy Take-Home Doses and Opioid Overdose and Treatment Interruption and Discontinuation.
Topics: Adult; Analgesics, Opioid; Buprenorphine; COVID-19; Female; Humans; Male; Medication Adherence; Methadone; Naloxone; Narcotic Antagonists; Ontario; Opiate Overdose; Opiate Substitution Treatment; Practice Patterns, Physicians'; Propensity Score; Retrospective Studies | 2022 |
Consensus-Based Guidance on Opioid Management in Individuals With Advanced Cancer-Related Pain and Opioid Misuse or Use Disorder.
Topics: Analgesics, Opioid; Benzodiazepines; Buprenorphine; Cancer Pain; Consensus; Female; Humans; Male; Methadone; Naloxone; Neoplasms; Opioid-Related Disorders | 2022 |
Flexible Buprenorphine/Naloxone Treatment Models: Safe and Effective in Reducing Opioid Use Among Persons With Prescription Opioid Use Disorder.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Humans; Methadone; Naloxone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Prescriptions | 2022 |
Changes and trends in medication-assisted treatment in Israel.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Israel; Methadone; Naloxone; Opioid-Related Disorders; Pharmaceutical Preparations | 2023 |
Harm reduction behaviors are associated with carrying naloxone among patients on methadone treatment.
Topics: Analgesics, Opioid; Drug Overdose; Harm Reduction; Humans; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders | 2023 |
Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Hydromorphone; Male; Methadone; Naloxone; Opiate Substitution Treatment; Opioid-Related Disorders; Pain | 2023 |
Opioid poisoning in Newcastle over the last three decades: From heroin to prescription opioids.
Topics: Adult; Analgesics, Opioid; Australia; Codeine; Female; Heroin; Humans; Male; Methadone; Naloxone; Oxycodone; Poisoning; Prescriptions | 2023 |
Naloxone prescriptions among patients with a substance use disorder and a positive fentanyl urine drug screen presenting to the emergency department.
Topics: Analgesics, Opioid; Cocaine; Drug Overdose; Emergency Service, Hospital; Fentanyl; Humans; Illicit Drugs; Methadone; Naloxone; Opioid-Related Disorders; Prescriptions; Retrospective Studies | 2023 |