methadone has been researched along with morphine in 1197 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 604 (50.46) | 18.7374 |
| 1990's | 123 (10.28) | 18.2507 |
| 2000's | 185 (15.46) | 29.6817 |
| 2010's | 211 (17.63) | 24.3611 |
| 2020's | 74 (6.18) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Carroll, FI; Che, T; Huang, XP; Jin, J; Karpiak, J; Kroeze, WK; Lansu, K; Liu, J; McCorvy, JD; Nagase, H; Roth, BL; Shoichet, BK | 1 |
| Mehta, VL | 1 |
| Ahtee, L; Kääriäinen, I | 3 |
| Leander, JD; McMillan, DE | 2 |
| McIndewar, I; Sugrue, MF | 1 |
| Davis, DC; Holtzman, SG; Shannon, HE | 1 |
| Goldstein, MG; Sollod, RM | 1 |
| Geller, I; Hartmann, RJ | 1 |
| Oka, T; Sawa, A | 1 |
| Berkowitz, BA | 1 |
| Chi, CH; Dixit, BN | 1 |
| Blundell, C; Slater, P | 1 |
| Halpern, LM | 2 |
| Dykstra, LA; McMillan, DE | 1 |
| Kaistha, KK; Tadrus, R | 1 |
| Segal, DS | 1 |
| Browne, RG; Derrington, DC; Segal, DS | 1 |
| Herndon, BL; Ringle, DA | 2 |
| Geber, WF; Hung, CY; Lefkowitz, SS | 2 |
| Breivik, H | 1 |
| Lukoff, IF | 1 |
| Almasi, J; Carlson, KR | 2 |
| Yaksh, TL | 1 |
| Dvorchik, BH; Hartman, RD; Stenger, VG | 1 |
| Extein, I; Gold, MS; Kleber, HD; Pottash, AL; Redmond, DE | 1 |
| Howd, RA; Pryor, GT | 1 |
| Bergmann, F; Chaimovitz, M; Pasternak, V | 1 |
| Oka, T | 1 |
| Beleslin, D | 1 |
| Hrdina, PD; Ling, GM; Merali, Z; Singhal, RL | 1 |
| Dombrosky, JT; Thomas, JA | 1 |
| Kay, DC | 1 |
| Huidobro, F; Huidobro-Toro, JP; Leong Way, E | 1 |
| Dewey, WL; Forbes, JE | 1 |
| Creese, I; Feinberg, AP; Snyder, SH | 1 |
| Donovan, MP; Shahid-Salles, KS; Thomas, JA | 1 |
| Terenius, L | 6 |
| Ho, TK; LaBella, FS; Pinsky, C | 1 |
| Khazan, N; Meltzer, LT; Moreton, JE | 1 |
| Griffith, JD; Jasinski, DR; Pevnick, JS | 1 |
| Cameron, IL; Sheridan, PJ; Smith, NR | 1 |
| Khazan, N; Steinfels, GF; Young, GA | 2 |
| Barnett, A; Fiedler, E; Goldstein, J; Taber, R | 1 |
| Gianutsos, G; Lal, H; Puri, SK | 1 |
| LaBella, FS | 1 |
| Richards, RK | 1 |
| Dent, R; Guyda, H; Tolis, G | 1 |
| Di Gregorio, GJ; Knaiz, EK; Nagle, BT; Piraino, AJ | 1 |
| Ahtee, L; Carlsson, A | 1 |
| Dorus, W; Renault, PF; Senay, EC | 1 |
| Anderson, O; Eriksen, PB | 1 |
| Castro, A; Malkus, H | 1 |
| Parkhouse, RJ | 1 |
| Charuvastra, VC; Ouren, J; Panell, J | 1 |
| Gianutsos, G; Lal, H | 2 |
| Cavanagh, K; Draisey, TF; Thibert, RJ | 1 |
| Gebhart, E | 1 |
| Kreek, MJ; Oratz, M; Rothschild, MA | 1 |
| McKearney, JW; Smith, JB | 1 |
| Chiba, S; Khazan, N; Moreton, JE; Young, GA | 1 |
| Jones, BE; Prada, JA | 1 |
| Downs, DA; Harrigan, SE | 1 |
| Chance, WT; Krynock, GM; Rosecrans, JA | 1 |
| Clouet, DH; O'Callaghan, JP; Williams, N | 1 |
| Evans, DB; Liu, SJ; Wang, RI | 1 |
| Sprague, GL; Takemori, AE | 1 |
| Spoerlein, MT; VanderWende, C | 1 |
| Holtzman, SG | 3 |
| Eikenburg, DC; Stickney, JL | 1 |
| Downs, DA; Wiley, JN | 1 |
| Donzanti, BA; Warwick, RO | 1 |
| Glennon, RA; Rosecrans, JA | 1 |
| Friedler, G; Wheeling, HS | 1 |
| Davis, WM; Smith, SG; Werner, TE | 2 |
| Chiba, S; Khazan, N; Moreton, EJ | 1 |
| Huidobro, F | 2 |
| Hine, CH; Masten, LW; Way, EL | 1 |
| Masten, LW | 1 |
| Babbini, M; Bartoletti, M; Gaiardi, M | 3 |
| Leander, JD | 2 |
| Anggård, E | 1 |
| Elchisak, MA; Harry, GJ; Rosecrans, JA | 1 |
| Catlin, DH; Hui, KK; Li, CH; Loh, HH | 1 |
| Buttery, JE; de Witt, DF; Lopez, JB | 1 |
| Johnson, JH; Maughan, GT; Rosecrans, JA | 1 |
| Castro, A; Mittleman, R | 1 |
| Peters, MA | 1 |
| Aigner, TG; Balster, RL; Ford, RD | 1 |
| Eastman, M | 1 |
| Sprague, GL; Takermori, AE | 1 |
| Chen, RC; Ho, AK; Ho, CC | 1 |
| Muir, WW; Sheehan, WC; Skarda, RT | 1 |
| Ho, IK; Mehendale, HM | 1 |
| Harford, RJ; Kleber, HD | 1 |
| Jakubovic, A; McGeer, EG; McGeer, PL | 1 |
| Sheridan, PJ | 1 |
| DeAngelis, GG; McCaslin, FC; Ungerleider, JT | 1 |
| Christenson, J; Cleeland, R; Davis, R; Grunberg, E; Heveran, J; Usategui-Gomez, M | 1 |
| Cerceo, E; Kin, HJ | 1 |
| Blachly, P; Carter, CC; Irwin, S; Marks, J | 1 |
| Charuvastra, VC; Kaim, SC; Klett, CJ; Ling, W | 1 |
| Lefkowitz, SS; Nemeth, D | 1 |
| Baeder, H; Herndon, BL; Paull, K; Ringle, DA | 1 |
| Russell-Taylor, WJ | 1 |
| Kelleher, RT | 1 |
| Schuster, CR | 1 |
| Archer, S | 1 |
| Brocco, MJ; Killam, KF; Robinson, CA | 1 |
| Guerrant, GO; Hall, CT | 1 |
| Stickney, JL | 1 |
| Judis, J | 2 |
| Rosecrans, JA; Spencer, RM | 1 |
| Leander, JD; Lucot, JB | 1 |
| Brindley, DN; Dodds, PF; Sanderson, RF | 1 |
| Berkowitz, BA; Lee, CH | 1 |
| Carney, JM; Rosecrans, JA | 1 |
| Berkowitz, DS; Loew, GH; Newth, RC | 1 |
| Jhamandas, K; Moffat, JA | 1 |
| Bartolomé, M; Lau, C; Seidler, FJ; Slotkin, TA | 1 |
| Haigler, HJ | 1 |
| Gray, AP; Guardina, WJ | 2 |
| Holtzman, SG; Shannon, HE | 1 |
| Lunde, PK; Skjoto, J; Teisberg, P | 1 |
| Henwood, RW; Mazurkiewicz-Kwilecki, I | 1 |
| Austin, DL; Caddy, GR; Gottheil, E | 1 |
| McNamee, HB; Meyer, RE; Mirin, SM | 1 |
| Chen, RC; Ho, AK | 1 |
| Anggård, E; Eriksson, JH; Holmstrand, J; Jacob, RG | 1 |
| Gibson, TC | 1 |
| Burkhalter, A; Masten, LW; Peterson, GR; Way, EL | 2 |
| Joffe, JM; Smith, DJ | 1 |
| Banford, TA; Cordova, VF | 1 |
| Huang, JT; Takemori, AE | 1 |
| Janda, R; Kaistha, KK; Tadrus, R | 1 |
| Fultz, JM; Senay, EC | 1 |
| Comaty, JE; Ehrenpreis, S; Greenberg, J | 1 |
| Prianishnikova, NT; Tolstikova, GV | 1 |
| Murgia, E; Walton, HF | 1 |
| Reuland, DJ; Trinler, WA | 1 |
| Deacon, MA; Iorio, LC; Ryan, EA | 1 |
| Colpaert, FC; Janssen, PA; Lal, H; Niemegeers, CJ | 1 |
| Cox, BM; Ginsburg, M; Willis, J | 1 |
| Henderson, GL; Rosenkranz, RP | 1 |
| Alexander, GJ | 2 |
| Chan, EM; Olsen, GD; Riker, WK | 1 |
| Harris, LS; Leander, JD; McMillan, DE | 2 |
| McCarthy, DA; McLean, JR; Nuite, JA; Tessman, DK; Wax, J | 1 |
| Nelson, PE; Selkirk, RC | 1 |
| Greenstein, RA; Mintz, J; O'Brien, CP; Woody, GE | 1 |
| Bell, RD; Cicero, TJ; Koch, GA; Meyer, ER | 1 |
| Goldstein, A | 2 |
| Craft, RM; Dykstra, LA | 2 |
| Maneckjee, R; Minna, JD | 2 |
| Alkadhi, KA; Hogan, YH | 1 |
| Billings, B; Candido, J; Duttaroy, A; Inturrisi, CE; Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Olley, JE; Pierce, TL; Tiong, GK | 2 |
| Balabanova, S; Boschek, HJ; Hermann, B; Scheitler, H; Schneider, E; Wepler, R | 1 |
| Bacosi, A; Caronna, A; Di Carlo, S; Pacifici, R; Pichini, S; Zuccaro, P | 1 |
| Derks, J | 2 |
| Chui, PT; Gin, T | 1 |
| Goldberg, SR; Grayson, NA; Jaffe, JH; Johnson, RE; Katz, JL; Rice, KC; Witkin, JM | 1 |
| Kapitsopoulos, G; Makhay, MM; Steigerwald, ES; Young, AM | 1 |
| Desmond, DP; Esquivel, M; Maddux, JF; Vogtsberger, KN | 1 |
| Bonde, J; Christrup, LL; Jonsson, T | 1 |
| Ennis, M; Lorenz, W; Nehring, E; Schneider, C | 1 |
| Breimer, DD; de Boer, AG; van Hoogdalem, E | 1 |
| Dove, B; Göres, E; Morgenstern, E | 1 |
| Negus, SS; Picker, MJ; Powell, KR | 1 |
| Dykstra, LA; Oliveto, AH; Picker, MJ | 1 |
| Abbrederis, K; Drexel, H; Dzien, A; Lang, AH | 1 |
| Enters, EK; Guo, HZ; Ko, DJ; Pandey, U; Robinson, SE | 1 |
| Balfour, HH; Gekker, G; Jackson, B; Peterson, PK; Sharp, BM | 1 |
| Bochner, F; Eichelbaum, M; Mikus, G; Somogyi, AA | 1 |
| Burnett, D; Richens, A; Smith, BL; Toseland, PA; Walker, G; Williams, J; Wilson, JF | 1 |
| Kapitsopoulos, G; Makhay, MM; Young, AM | 1 |
| Berde, CB; Beyer, JE; Bournaki, MC; Levin, CR; Sethna, NF | 1 |
| Brody, MC; Chabal, C; Jacobson, L; Ward, RJ; Wasse, L | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Doty, P; Dykstra, LA; Mattox, SR; Negus, SS; Picker, MJ | 1 |
| Adams, JU; Holtzman, SG; Paronis, CA | 1 |
| Bailey, PL; Digre, KB; Jaeckle, KA; Jones, CR; McMahill, PC | 1 |
| Cherry, DA; Cousins, MJ; Gourlay, GK; Plummer, JL | 1 |
| Berde, CB; Beyer, JE; McGrath, PJ | 1 |
| Frank, GB; Kokate, TG | 1 |
| Foley, KM; Grabinski, PY; Inturrisi, CE; Kaiko, RF; Li, CH; Max, MB | 1 |
| Foley, KM; Inturrisi, CE; Moulin, DE; Portenoy, RK; Rogers, A | 1 |
| Coleman, RR; Lo, SL | 1 |
| Grochow, LB; Hausheer, F; Kumor, KM | 1 |
| Foley, KM; Houde, RW; Inturrisi, CE; Moulin, DE; Nip, TJ; Reidenberg, B; Wallenstein, S; Weinberg, DS | 1 |
| Enterline, J; Green, L; Grochow, L; Grossman, S; Sheidler, V | 1 |
| Brummitt, C; Bullock, M; Gekker, G; Hitt, J; Pentel, P; Peterson, PK; Sharp, B; Simpson, M | 1 |
| Dickenson, AH; McQuay, HJ; Smallman, K; Sullivan, AF | 1 |
| Koren, G; Maurice, L | 1 |
| Ivarsson, M; Neil, A | 1 |
| Adler, MW; Furman, MB; Geller, EB; Lynch, TJ; Martinez, RP | 1 |
| Dykstra, LA; Oliveto, A; Picker, M | 1 |
| Bustamante, D; Paeile, C; Pelissier, T; Saavedra, H; Tampier, L; Vergara, V | 1 |
| Kaa, E; Steentoft, A; Worm, K | 1 |
| Brody, MC; Chabal, C; Ireton, RC; Jacobson, L; Ward, RJ | 1 |
| Deshpande, JK; Maxwell, LG; Yaster, M | 1 |
| Blancquaert, JP; Lefebvre, RA; Willems, JL | 1 |
| Dykstra, LA; Massie, CA; Picker, M | 1 |
| Culpepper-Morgan, J; Holt, PR; Kreek, MJ; LaRoche, D; O'Bryan, L; Zhang, J | 1 |
| Di Chiara, G; Imperato, A | 1 |
| Carino, MA; Horita, A; Yamawaki, S | 1 |
| Hyttel, J; Larsen, JJ | 1 |
| Neil, A; Terenius, L | 1 |
| Cotev, S; Magora, F | 1 |
| Hong, O; Khazan, N; Young, G | 1 |
| Jellema, JG | 1 |
| Cook, CC; Lipsedge, MS | 1 |
| Consolo, S; Forloni, G; Ladinsky, H; Palazzi, E | 1 |
| Sica, DA; Wolfert, AI | 1 |
| Hellebrekers, LJ; Mol, JA; van den Brom, WE | 1 |
| Harty, GJ; Onofrio, BM; Yaksh, TL | 1 |
| Boone, DJ; Caudill, SP; Hansen, HJ | 1 |
| Bucarelli, A; De Montis, MG; Devoto, P; Tagliamonte, A | 1 |
| Chiang, CN; Lee, CC | 1 |
| Domino, EF | 1 |
| Hynes, MD; Leander, JD; Reel, JK; Zimmerman, DM | 1 |
| Avico, U; Belogi, L; Borelli, G; Cavallo, G; Croce, C; Santiangeli, C; Tubaro, E | 1 |
| Choi, DW; Viseskul, V | 1 |
| Bero, L; Field, E; Ignar, D; Kuhn, C; Lurie, S | 1 |
| Clarke, KW; Paton, BS | 1 |
| Contreras, E; Fernández, E; Villar, M | 1 |
| Arraztoa, J; Hernández, A; Paredes, H; San Martín, S | 1 |
| Dykstra, LA; Picker, M | 1 |
| Inturrisi, CE; Yoburn, BC | 1 |
| Mangoura, D; Sakellaridis, N; Vernadakis, A | 1 |
| Frank, GB; Shetty, SS | 2 |
| Cherry, DA; Cousins, MJ; Gourlay, GK | 1 |
| Agren, H | 1 |
| Bianchi, M; De Conno, F; Ripamonti, C; Sbanotto, A; Ventafridda, V | 1 |
| Dykstra, LA; Heise, JW; Picker, M | 1 |
| Rogers, AG | 2 |
| Eriksson, PS; Rönnbäck, L; Rosengren, L; Wronski, A; Zeuchner, J | 1 |
| Paule, MG; Wenger, GR | 1 |
| Drenger, C; Evron, S; Freund, E; Rosenbaum, H | 1 |
| Caine, M; Drenger, B; Evron, S; Magora, F | 1 |
| Jasinski, DR; Preston, KL | 1 |
| Harvey, RC; Inturrisi, CE; Madsen, J; Payne, R | 1 |
| Inturrisi, CE; Payne, R | 1 |
| Gourlay, GK; Lamberty, J; Willis, RJ | 1 |
| Cohen, A; Inturrisi, CE; Ling, GS; Umans, JG; Yoburn, BC | 1 |
| Bateman, DN; Blain, PG; Lane, RJ; Rawlins, MD | 1 |
| Liu, SJ; Wang, RI | 2 |
| Hovious, JR; Peters, MA | 2 |
| Babbini, M; Bacchi, A; Bartoletti, M; Gaiardi, M; Gubellini, C | 1 |
| Drenger, B; Evron, S; Magora, F; Samueloff, A; Simon, A | 1 |
| Derendorf, H; Garrett, ER; Mattha, AG | 1 |
| Parker, CW; Ryan, JJ; Williams, RC | 1 |
| Gorodetzky, CW | 1 |
| Baden, MM; Huang, JC | 1 |
| Bastos, ML; Jukofsky, D; Mulé, SJ | 1 |
| Kreuzer, H; Spiller, P | 1 |
| Baettig, P; Bucher, K; Logara-Kalantzis, A | 1 |
| Caldwell, J; Sever, PS | 1 |
| Brister, CC; Davis, WM | 2 |
| Prianishnikova, NT; Raevskii, KS | 2 |
| Cadden, JJ; Feigelson, EB | 1 |
| Dole, VP; Kreek, MJ; Nyswander, ME | 2 |
| Elliott, HW; Hine, CH; Nomof, N; Parker, KD | 1 |
| Gavitt, J; Karmin, M; Smith, AA | 1 |
| Bewley, T | 1 |
| Ettinger, MJ; Gero, A | 2 |
| Orr, R; Scott, ME | 1 |
| Röthig, J | 1 |
| Fujimoto, JM; Wang, RI | 1 |
| Herz, A; Hess, R; Teschemacher, H; von Cube, B | 1 |
| Gero, A | 2 |
| Gourley, DR | 1 |
| Assouline, G | 1 |
| Hayashi, G; Maruyama, Y; Smits, SE; Takemori, AE | 1 |
| Kerr, FW; Pozuelo, J | 1 |
| Hill, RC; Römer, D | 1 |
| Bergmann, F; Chaimovitz, M; Pasternak, V; Ramu, A | 1 |
| Dole, VP | 1 |
| Contreras, E; Huidobro, F | 1 |
| Andryauskas, S; Broich, JR; Goldner, S; Hoffman, DB; Mulligan, D; Umberger, CJ | 1 |
| Goldstein, A; Leute, R; Ullman, EF | 1 |
| Bastiani, RJ; Phillips, RC; Schneider, RS; Ullman, EF | 1 |
| Brattin, WJ; Sunshine, I | 1 |
| Leute, R | 1 |
| Collier, HO; Roy, AC | 2 |
| Elliott, HW; Garcia, JF; Kokka, N | 1 |
| Bauer, G; Konzett, H; Ziegler, E | 1 |
| Boura, AL; Haddlesey, DI; Harry, EJ; Lewis, JW; Mayor, PA | 1 |
| Beattie, JM; Demetriou, JA; Lowe, ML; Weissman, N | 1 |
| Andryauskas, S; Broich, JR; Goldner, SJ; Hoffman, DB; Umberger, CJ | 1 |
| Krstić, MK | 3 |
| Bowman, WC; Buwembo, JB | 1 |
| Stesin, AJ; Takemori, AE; Tulunay, FC | 1 |
| Takemori, AE; Tulunay, FC | 1 |
| Jones, WL; Tuason, VB | 1 |
| Irey, NS | 1 |
| Higgins, TN; Taylor, JD | 1 |
| Harwood, CT | 1 |
| Marks, MJ; Medzihradsky, F | 1 |
| Geber, WF; Schramm, LC | 1 |
| Goodlet, I; Sugrue, MF | 2 |
| Digregorio, GJ | 1 |
| Sugrue, MF | 1 |
| Teiger, DG | 1 |
| Edelman, I; Hiller, JM; Simon, EJ | 1 |
| Dickinson, G; Jhamandas, K | 1 |
| Mule, SJ | 1 |
| Jamison, K; Price, S | 1 |
| DuPont, RL; Katon, RN; McGinniss, MH; Sherwood, GK; Webster, JB | 1 |
| Kaneto, H; Koida, M; Nakanishi, H | 1 |
| Vandam, LD | 1 |
| Lamb, D; Roberts, G | 1 |
| McBay, AJ | 1 |
| Simon, EJ | 1 |
| Donald, KW; Kerr, F | 1 |
| McMillan, DE | 1 |
| Frings, CS | 1 |
| Cushman, P; Grieco, MH | 1 |
| Frings, CS; Queen, CA | 1 |
| Ciofalo, FR | 2 |
| Neman, RL | 1 |
| Gulkus, SP; Walls, RT | 1 |
| Carpenter, RW; Haertzen, CA; Jasinski, DR; Jones, BE; Kay, DC; Mansky, PA; Martin, WR | 1 |
| Pert, CB; Snyder, SH | 1 |
| Kubasik, NP; Sine, HE; Woytash, J | 1 |
| Sohn, D | 1 |
| Carmichael, FJ; Israel, Y | 1 |
| Jurand, J; Knox, JH | 2 |
| Colasanti, B; Khazan, N | 1 |
| Choulis, NH | 1 |
| Catlin, D; Cleeland, R; Grunberg, E | 1 |
| Ahtee, L; Saarnivaara, L | 1 |
| Donoso, E; Lipski, J; Stimmel, B | 1 |
| Cushman, P | 1 |
| Horng, JS; Wong, DT | 1 |
| Andersen Lund, BM; Ellekjaer, EF | 1 |
| Ghezzi, D; Mauron, C; Samanin, R; Valzelli, L | 1 |
| Cameron, JM; Robinson, AE | 1 |
| Holder, AT; Robinson, AE | 2 |
| Montel, H; Starke, K | 1 |
| Marks, MJ; Medzihradsky, F; Metcalfe, JI | 1 |
| Fitch, FW; Hill, JH; Rothberg, RM; Wainer, BH | 1 |
| Gray, AP; Robinson, DS | 1 |
| Fjalland, B; Lassen, N; Nielsen, IM; Pedersen, V; Petersen, PV | 1 |
| Kreek, MJ | 1 |
| Gorodetzky, CW; Kullberg, MP | 1 |
| Grunberg, E; Klein, B; Sheehan, JE | 1 |
| Haertzen, CA; Hooks, NT; Pross, M | 1 |
| Burke, DH; Mann, DE | 1 |
| Horwitz, CA; Jerome, E; Paulson, C; Ross, R; Stearns, J; Ward, PC | 1 |
| Froede, RC; Irey, NS | 1 |
| Cimbura, G; Kofoed, J | 1 |
| Ahtee, L; Boullin, DJ; Paasonen, MK; Saarnivaara, L | 1 |
| Kubasik, NP; Rejent, TA; Sine, HE | 1 |
| Abola, EE; Deutsch, HF; Edmundson, AB; Ely, KR; Fausch, MD; Girling, RL; Schiffer, M; Westholm, FA | 1 |
| Beeler, GW; Kerr, FW; Triplett, JN | 1 |
| Bowers, MB; Kleber, HD | 1 |
| Baden, MM; Valanju, NN; Valanju, SN; Verma, SK | 1 |
| Ho, IK; Loh, HH; Way, EL | 1 |
| Baker, SL | 1 |
| Buccafuri, A; Morgenstern, S; Sansur, M | 1 |
| Elmowafi, AA; Gronlund, JA; Kenison, LT; Loveridge, EL | 1 |
| Brown, JH; Garrett, RL | 1 |
| Kumar, R; Stolerman, IP | 1 |
| Hornykiewicz, O; Kuschinsky, K | 1 |
| Fink, M; Freedman, AM; Zaks, A | 1 |
| Arnold, PJ; Falek, A; Jordan, RB; King, BJ; Skelton, WD | 1 |
| Bastos, ML; Chedekel, M; Jukofsky, D; Mulé, SJ; Saffer, E | 1 |
| Alling, S; Kaplan, E; Mayron, LW | 1 |
| Braun, L; Hyman, S; Oldendorf, SZ; Oldendorf, WH | 1 |
| Michaux, WW; Nightingale, SL; Platt, PC | 1 |
| Adler, FL; Liu, CT | 1 |
| Goode, PG | 1 |
| Baselt, RC; Casarett, LJ | 1 |
| Heifetz, SA; McMillan, DE | 1 |
| Ginsburg, M | 1 |
| Geerlings, PJ; van der Helm, HJ; van der Slooten, EP | 1 |
| Jhamandas, K; Phillis, JW; Pinsky, C | 1 |
| Halbach, H | 1 |
| Dobbs, WH | 1 |
| Ladd, SL; Wallace, JE | 1 |
| Ball, JC; Urbaitis, JC | 1 |
| Portoghese, PS | 1 |
| Marshall, AS; Weinstock, M | 1 |
| Kreppel, E | 1 |
| Dundee, JW; Loan, WB; Morrison, JD | 1 |
| Sulman, FG; Weller, CP | 1 |
| Bendick, F; Greenwald, W; Short, CE | 1 |
| Molinengo, L; Ricci-Gamalero, S | 1 |
| Smits, SE; Takemori, AE | 2 |
| Schou, J; Worm, K | 1 |
| Carchman, RA; McMillan, DE; Wolf, PS | 1 |
| Goldstein, A; Richter, JA | 1 |
| Antopol, W; Chryssanthou, C | 1 |
| Kamei, C; Kaneto, H; Nakanishi, H; Shimomura, K | 1 |
| Calise, JP; Coumbis, RJ; Fulton, CC; Rodriguez, C | 1 |
| Elliott, HW | 1 |
| Rethy, CR; Smith, CB; Villarreal, JE | 1 |
| Bolego Zonta, N; Genovese, E; Napoli, PA; Tammiso, R | 1 |
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| Ammar, D; Baron, L; Chvetzoff, G; Collin, E; Delorme, C; Delorme, T; Faure, S; Filbet, M; Hubault, P; Jovenin, N; Krakowski, I; Magnet, M; Michenot, N; Minello, C; Poulain, P; Rostaing, S | 1 |
| Artioli, T; Bevilacqua, J; Bloomstone, J; Graicer, G; Lambert, MF; Moro, ET; Pereira, AL | 1 |
| Gregory, PJ; Hein, DJ; Risoldi Cochrane, Z; Slowiczek, L | 1 |
| Beck, O; Böttcher, M; Picht, F | 1 |
| Kraft, WK; Mangat, AK; Schmölzer, GM | 1 |
| Ambrósio, CE; Carregaro, AB; Cordeiro, YG; Fukumasu, H; Melo, CF; Roballo, KC; Schwarzbach, SV; Xavier, PLP | 1 |
| Heller, NM; Maher, DP; Walia, D | 1 |
| Moerke, MJ; Negus, SS | 1 |
| Belcher, AM; Billing, AS; Bonaventura, J; Bonifazi, A; Cai, NS; Casadó, V; Casadó-Anguera, V; Cole, TO; Ferré, S; Greenblatt, AD; Guitart, X; Jacobson, AE; Lam, S; Massey, E; Michaelides, M; Moreno, E; Newman, AH; Purks, J; Quiroz, C; Rea, W; Rice, KC; Volkow, ND; Wagner, M; Weintraub, E; Winkelman, JW; Wish, ED | 1 |
| Del Valle Arnáez, G; Santos Suárez, J | 1 |
| Fairbairn, N; Giacomuzzi, SM; Gorfinkel, L; Klimas, J; Ruckes, C; Socías, ME; Wood, E | 1 |
| Futamura, A; Nakagawa, T; Suga, Y; Sugawara, H; Suzuki, S; Takase, H; Torigoe, K; Uchida, M; Uesawa, Y | 1 |
| Baumgartner, MR; Gastberger, S; Herdener, M; Hulka, LM; Mutschler, J; Quednow, BB; Seifritz, E; Soyka, M | 1 |
| Caffaro, MM; Fennell, TR; Mortensen, NP; Snyder, RW; Yueh, YL | 1 |
| Aguirre, J; Bastian, K; Buehler, PK; Hollinger, A; Lecheler, L; Rüst, CA; Siegemund, M; Slizyte, D; Studer, W; Toft, K | 1 |
| Serafini, RA; Zachariou, V | 1 |
| Cooney, H; Davis, P; Hodgson, K | 1 |
| Cook, CE; Fantasia, HC | 1 |
| Chen, J; Davis, JM; Eisler, L; Lee, JJ; Li, G; Sun, LS | 1 |
| Andersen, JM; Austdal, LPE; Fjelldal, MF; Hadera, MG; Kongstorp, M; Paulsen, RE; Šulović, A | 1 |
| Ardid, D; Authier, N; Bertin, C; Brousse, G; Chenaf, C; Delorme, J; Eschalier, A; Peyrière, H; Riquelme, M | 1 |
| Minear, S; Wachman, EM | 1 |
| Xiao, F; Yan, K; Zhou, W | 1 |
| Chang, YH; Chen, P; Chen, SH; Chen, SL; Chin Chen, K; Chu, CH; Hong, JS; Huang, SY; Kuang Yang, Y; Lee, IH; Lee, SY; Lin, SH; Lu, RB; See Chen, P; Tzeng, NS; Wang, TY | 1 |
| Garra, R; Sbaraglia, F | 1 |
| Afarinesh, MR; Golshan, F; Haghpanah, T; Sabzalizadeh, M; Shafiei, F; Sheibani, V; Zangiabadi, I | 1 |
| MacMillan, KDL | 1 |
| Degenhardt, L; Gisev, N; Hall, WD; Roxburgh, A | 1 |
| Casuccio, A; David, F; Mercadante, S; Spedale, VM; Villari, P | 1 |
| Ahmadi, AA; Asouri, M; Gholami, M; Nasirikenari, M; Rostamnezhad, M; Saboory, E | 1 |
| Khan, L | 1 |
| Bogen, DL; Czynski, AJ; Dansereau, LM; Davis, JM; Engelhardt, B; Hudak, ML; Lester, BM; Marro, P; Oliveira, EL; Shenberger, J; Wachman, EM | 1 |
| Evrard, CA; Haas, DM; Haneline, LS; Jones, DR; Masters, AR; Metzger, IF; Quinney, SK; Thomas, AE | 1 |
| Bobby, LE; Frazier, LM; Gawronski, KM | 1 |
| Dart, RC; Green, JL; Olsen, H; Severtson, G; Wang, GS | 1 |
| Bach, P; Brar, R; Dong, H; Fairbairn, N; Murphy, SM; Socias, ME; Wood, E | 1 |
| McPherson, ML | 1 |
| Akbari, P; Miladi-Gorji, H; Najafi, M; Rezaei, AM | 1 |
| Hum, A; Tan, C; Wong, JF; Yee, CM | 1 |
| Brockbals, L; Kraemer, T; Staeheli, SN; Steuer, AE | 1 |
| Brusseau, C; Burnette, T; Heidel, RE | 1 |
| Galeone, C; Mariani, L; Motta, G; Proto, PL; Tognoli, E; Valenza, F | 1 |
| Baschirotto, C; Kuhn, S; Lehmann, K; Reimer, J; Verthein, U | 1 |
| Bove, J; Carlin, K; Deodhar, P; Jennings, R; McDaniel, CE; Test, M | 1 |
| Braz, FR; Mattar, LA; Módolo, NSP; Navarro E Lima, LH; Pontes, JPJ; Sousa, JAG | 1 |
| Camardo, SA; Czynski, AJ; Dansereau, LM; Davis, JM; Flannery, T; Lester, BM; Oliveira, EL | 1 |
| Churchill, B; Root-Bernstein, R; Turke, M | 1 |
| Conboy, JC; Sly, KL; Tran, RJ | 1 |
| Dehpour, AR; Esmaeili, J; Mumtaz, F; Nezamoleslami, S; Shafaroodi, H; Sheibani, M | 1 |
| Crowley, M; Ford, S; Kaplan, HC; Kuhnell, P; Lannon, C; Macaluso, M; McClead, R; Provost, LP; Walsh, MC; Wexelblatt, S | 1 |
| Gmeiner, G; Nicolakis, J; Reiter, C; Seltenhammer, MH | 1 |
| Aduroja, O; Biggs, JM; El-Metwally, D; Gopalakrishnan, M; Wijekoon, N | 1 |
| Amato, L; Bellisario, C; Davoli, M; Ferri, M; Jahanfar, S; Minozzi, S | 1 |
| Andersen, CU; Andersen, FD; Simonsen, U | 1 |
| Ciftcioglu, J; Eckstein, N; Haas, B; Jermar, S; Kaina, B; Weickhardt, S | 1 |
| Adeniyi-Jones, S; Aghai, ZH; Boelig, RC; Carola, D; Greenspan, JS; Kraft, WK; Lafferty, M; Smith, J | 1 |
| Akinbi, H; Butler, D; Emoto, C; Fukuda, T; McPhail, BT; Vinks, AA | 1 |
| Tobias, JD | 1 |
| Grönbladh, A; Hallberg, M; Nyberg, F; Nylander, E; Zelleroth, S | 1 |
| van den Anker, J | 1 |
| Aranda, F; Arriaza, N; Kirmayr, M; Madrid, E; Matta, M; Papuzinski, C; Stojanova, J | 1 |
| Backmund, M; Baschirotto, C; Görne, H; Jacobsen, B; Kuhn, S; Lehmann, K; Reimer, J; Scherbaum, N; Verthein, U; Walcher, S | 1 |
| Altenburger, MJ; Auwärter, V; Henkel, K; Klima, M; Neukamm, MA | 1 |
| Davey, JG; Martin, J; Osborn, DA; Zankl, A | 1 |
| Beck, O; Böttcher, M; Keller, T; Lierheimer, S; Monticelli, FC | 1 |
| Duarte, FCN; Ferraro, LHDC; Ferreira, A; Sakata, RK | 1 |
| Aguilar, L; Álvarez-Navares, A; Casado-Espada, N; Gamonal-Limcaoco, S; Grau-López, L; Lozano-López, MT; Roncero, C; Vicente-Hernández, B | 1 |
| Brothers, TD; Fraser, J; MacAdam, E; Morgan, B; Webster, D | 1 |
| Astronomo, R; Gornalusse, GG; Hladik, F; Hughes, SM; Kim, Y; Levy, CN; McElrath, J; Ochsenbauer, C; Pandey, U; Valdez, R; Vojtech, LN | 1 |
| Eidbo, SA; Hagedorn, JD; Kaufman, DE; Kropp Lopez, AK; Mathew, V; McCall, KL; Nichols, SD; Piper, BJ | 1 |
| Miladi-Gorji, H; Pourhassanali, N; Zarbakhsh, S | 1 |
| Giet, O; Laurent, S; Picard, S; Seresse, L; Treillet, E | 1 |
| Hajizadeh, MR; Karimabad, MN; Mahmoodi, M; Rezai, M; Torabizadeh, SA | 1 |
| Achuff, BJ; Causey, JC; Checchia, PA; Ghanayem, NS; Heinle, JS; Lemming, K; Sembera, KA | 1 |
| Loadsman, JA | 1 |
| Ambardekar, A; Carlson, A; Iskander, I; Pham, D; Price, C; Reisch, J | 1 |
| Douros, A; Farhat, I; Lim, J; Panagiotoglou, D | 1 |
| Gupta, M; MacMillan, KDL; Melvin, P; Morrison, TM; Murzycki, J; O'Shea, TF; Rothstein, R; Schiff, DM; Singh, R; Van Vleet, MW; Wachman, EM | 1 |
| Chiroma, MS; Hidayat Baharuldin, MT; Moklas, MAM; Suliman, NA; Taib, CNM | 1 |
| Badiei, A; Ghasemi, JB; Habibi, MM; Norouzi, P | 1 |
| Leeman, L; Sutter, MB; Watson, H; Weitzen, S; Yonke, N | 1 |
| Ashworth, J; Bifari, F; Buchhalter, A; Fant, R; Folli, F; Gauvin, D; Henningfield, J; Inturrisi, C; Lanier, R; Manfredi, PL; Pappagallo, M; Shram, M; Traversa, S | 1 |
| Christoffersen, DJ; Hermansen, SK | 1 |
| Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM | 1 |
| Andersen, CU; Andersen, FD; Arjmand, S; Hvingelby, V; Joca, S; Pinilla, E; Simonsen, U; Steffensen, SC | 1 |
| Abedini, M; Amirinejad, M; Haghpanah, T; Moinaddini, F; Nematollahi-Mahani, SN; Yoosefi, F | 1 |
| Noroozi, A; Rahimi-Movaghar, A | 1 |
| Jones, AW | 1 |
| Eisenbraun, A; Martin, E; Schaff, HV; Schroeder, D; Wittwer, ED | 1 |
| Buratti, E; Cerioni, A; Cingolani, M; Cippitelli, M; Froldi, R; Mietti, G; Scendoni, R | 2 |
| Arnet, I; Dürsteler, KM; Grossmann, F; Hersberger, KE; Jaiteh, C | 1 |
| Besharah, J; Campbell, T; Gomes, T; Kleinman, RA; Kolla, G; Ledlie, S; Leece, P; McCormack, D; Smoke, A; Sproule, B; Tadrous, M | 1 |
| Dunn, LK; Esfahani, K; Naik, BI; Tennant, W; Tsang, S | 1 |
| Annett, R; Bremer, D; Czynski, A; Das, A; Eggleston, B; Greenberg, R; Laptook, A; Lee, J; Lester, B; McGowan, E; Pedroza, C; Simon, A; Smith, B; Snowden, J | 1 |
| Antonijevic, M; Canals, M; Hill, R; Hosking, Y; Javitch, JA; Kruegel, AC; Lane, JR; Lemel, L; Mistry, SN; Sanchez, J | 1 |
| Bastos, FI; Bianchi, LM; Carvalho, RM; da Cunha, AJLA; de Magalhães-Barbosa, MC; Prata-Barbosa, A; Rodrigues-Santos, G | 1 |
| Andersen, JM; Boix, F; Khoder, A; Paulsen, RE; Rajalingam, D | 1 |
| Feldman, MS; Hand, I; Kim, MH; Noble, L; Wingert, WE; Yoon, JJ | 1 |
| Brassart, C; Codaccioni, X; Humbert, L; Lhermitte, M; Thibault, D; Vignau, J; Vinner, E | 1 |
| Choo, RE; Huestis, MA; Jones, HE; Murphy, CM | 1 |
| Choo, RE; Huestis, MA; Johnson, RE; Jones, HE; Kacinko, SL | 1 |
| Keith, L; Marin, SJ; McMillin, GA; Merrell, M | 1 |
| Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E | 1 |
| de Castro, A; Gray, TR; Huestis, MA; Johnson, RE; Jones, HE; Shakleya, DM | 2 |
| Concheiro, M; Concheiro-Guisán, A; Cruz-Landeira, A; de Castro, A; González-Colmenero, E; Lendoiro, E; López-Rivadulla, M | 1 |
| Delano, K; Gareri, J; Koren, G | 1 |
| Concheiro, M; Concheiro-Guisan, A; Cruz-Landeira, A; de Castro, A; Gónzalez-Colmenero, E; Lendoiro, E; López-Rivadulla, M; Macias-Cortiña, M; Peñas-Silva, P | 1 |
| Busardò, FP; Carlier, J; Di Trana, A; Huestis, MA; La Maida, N; Pichini, S; Tittarelli, R | 1 |
| Danell, AS; Forbes, L; Kew, K; Kuehn, D; Mamillapalli, SS; May, L; McIntyre, K; Poppenfuse, S; Ravisankar, S; Rushing, B; Smith-Joyner, A; Strom, C | 1 |
98 review(s) available for methadone and morphine
| Article | Year |
|---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Cholinergic mechanisms in narcotic analgesics.
Topics: Acetylcholine; Analgesics, Opioid; Animals; Brain Chemistry; Cats; Chlorpromazine; Choline; Meperidine; Methadone; Morphine; Nalorphine; Neurons; Neurotransmitter Agents; Parasympathetic Nervous System; Time Factors | 1975 |
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors | 1976 |
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Methadone; Morphine; Morphine Dependence; Naloxone; Propranolol; Protein Binding; Sex Factors; Substance-Related Disorders | 1976 |
Consequences of use. Heroin and other narcotics.
Topics: Adolescent; Adult; Behavior; Dose-Response Relationship, Drug; Drug Tolerance; Employment; Epidemiologic Methods; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Morphine; Patient Dropouts; Research; Role; Substance-Related Disorders; United States | 1977 |
Effects of narcotics on the reproductive system.
Topics: Adrenal Cortex; Animals; Corticosterone; Cortisone; Cyclic AMP; Female; Follicle Stimulating Hormone; Fructose; Humans; Hypothalamo-Hypophyseal System; Liver; Luteinizing Hormone; Male; Methadone; Morphine; Myometrium; Organ Size; Pregnancy; Rats; Reproduction; Semen; Testosterone; Thyroid Gland; Thyroid Hormones | 1977 |
Radioimmunoassays of drugs of abuse in humans: a review.
Topics: Amphetamines; Barbiturates; Body Fluids; Cocaine; Humans; Illicit Drugs; Lysergic Acid Diethylamide; Methadone; Methaqualone; Morphine; Nicotine; Pharmaceutical Preparations; Radioimmunoassay | 1977 |
Narcotic analgesics and aggression.
Topics: Aggression; Animals; Behavior, Animal; Electroshock; Humans; Methadone; Morphine; Parasympathomimetics; Rats; Receptors, Dopamine; Substance Withdrawal Syndrome | 1978 |
[The problem of mutagenic side effects of psychotropic substances. 2. Narcotics and addictive drugs].
Topics: Dose-Response Relationship, Drug; Ethanol; Female; Humans; Infant, Newborn; Lysergic Acid Diethylamide; Male; Mescaline; Methadone; Morphine; Mutation; Narcotics; Psilocybin; Substance-Related Disorders | 1979 |
Detection of drugs of abuse by radioimmunoassay: a summary of published data and some new information.
Topics: Amphetamine; Barbiturates; Cross Reactions; Drug Stability; Glutethimide; Humans; Methadone; Methaqualone; Morphine; Narcotics; Pharmaceutical Preparations; Radioimmunoassay; Saliva; Secobarbital; Substance-Related Disorders; Time Factors; Tranquilizing Agents | 1976 |
Pharmacology of LAAM.
Topics: Analgesics; Animals; Behavior, Animal; Dogs; Drug Evaluation, Preclinical; Female; Haplorhini; Humans; Kinetics; Male; Methadone; Methadyl Acetate; Mice; Morphine; Nalorphine; Rabbits; Rats; Stereoisomerism; Substance-Related Disorders; Time Factors | 1976 |
The heart in myasthenia gravis.
Topics: Arrhythmias, Cardiac; Cholinesterase Inhibitors; Drug Synergism; Electrocardiography; Heart; Humans; Lidocaine; Meperidine; Methadone; Morphine; Myasthenia Gravis; Myocarditis; Myocardium; Neuromuscular Junction; Phenytoin; Procaine; Quinidine; Vectorcardiography | 1975 |
[Delayed-action opioids--limitations and advantages].
Topics: Buprenorphine; Delayed-Action Preparations; Humans; Methadone; Morphine; Pain; Palliative Care | 1990 |
Pharmacokinetics of rectal drug administration, Part I. General considerations and clinical applications of centrally acting drugs.
Topics: Administration, Rectal; Antiemetics; Atropine; Carbamazepine; Clonazepam; Delayed-Action Preparations; Diazepam; Flunitrazepam; Humans; Hydromorphone; Intestinal Absorption; Methadone; Methohexital; Midazolam; Morphine; Pharmacokinetics; Phenobarbital; Valproic Acid | 1991 |
Opiates, human peripheral blood mononuclear cells, and HIV.
Topics: Acquired Immunodeficiency Syndrome; beta-Endorphin; Cells, Cultured; Heroin; HIV-1; Humans; Interferon-gamma; Leukocytes, Mononuclear; Methadone; Morphine; Respiratory Burst; Substance Abuse, Intravenous; T-Lymphocytes; Virus Replication | 1991 |
Pediatric uses of opioids.
Topics: Child; Child, Preschool; Codeine; Drug Interactions; Fentanyl; Humans; Infant; Infant, Newborn; Meperidine; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Pediatrics; Receptors, Opioid | 1989 |
The pharmacologic management of pain in children.
Topics: Analgesia, Epidural; Analgesics; Child; Child, Preschool; Codeine; Fentanyl; Humans; Infant; Meperidine; Methadone; Morphine; Naloxone; Narcotics; Pain | 1989 |
Receptor mechanisms for nociception.
Topics: Analgesics, Opioid; Animals; Codeine; Drug Tolerance; Methadone; Morphine; Naloxone; Neurons, Afferent; Nociceptors; Opioid-Related Disorders; Receptors, Opioid; Spinal Cord | 1986 |
Future trends in regional spinal opioids.
Topics: Analgesics, Opioid; Anesthesia, Epidural; Animals; Humans; Injections, Spinal; Kinetics; Lipids; Methadone; Morphine; Pain | 1986 |
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1986 |
The biochemical pharmacology of abused drugs. III. Cannabis, opiates, and synthetic narcotics.
Topics: Animals; Cannabis; Chemical Phenomena; Chemistry; Columbidae; Cricetinae; Dronabinol; Drug Tolerance; Half-Life; Humans; Memory, Short-Term; Meperidine; Methadone; Microsomes, Liver; Morphine; Narcotics; Neurotransmitter Agents; Opium; Pentazocine; Perception; Rats; Substance-Related Disorders; Synaptic Transmission; Teratogens | 1974 |
[Analgesics. 32].
Topics: Alphaprodine; Analgesics; Azepines; Benzimidazoles; Bridged-Ring Compounds; Codeine; Cyclazocine; Dextromoramide; Dextropropoxyphene; Fentanyl; Heroin; Humans; Hydromorphone; Isonipecotic Acids; Levallorphan; Levorphanol; Lysergic Acid Diethylamide; Methadone; Morphinans; Morphine; Nalorphine; Naphthoquinones; Oxymorphone; Pentazocine; Phenazocine; Phenoperidine | 1969 |
Interactions of narcotic antagonists with receptor sites.
Topics: Acetylcholine; Animals; Atropine; Binding Sites; Brain; Chromatography; Drug Tolerance; Electric Stimulation; Haplorhini; Humans; Kinetics; Levorphanol; Methadone; Mice; Molecular Conformation; Morphine; Naloxone; Narcotic Antagonists; Rats; Receptors, Drug; Structure-Activity Relationship; Substance Withdrawal Syndrome; Time Factors | 1973 |
Biochemistry of addiction.
Topics: Animals; Azepines; Brain; Drug Tolerance; Humans; Methadone; Morphinans; Morphine; Opium; Phenazocine; Piperidines; Receptors, Drug; Substance-Related Disorders; Synapses; Synaptic Transmission | 1970 |
Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.
Topics: Adenylyl Cyclases; Animals; Aspirin; Brain; Cyclic AMP; Depression, Chemical; Fluorides; Guinea Pigs; Heroin; In Vitro Techniques; Levorphanol; Meperidine; Methadone; Mice; Morphinans; Morphine; Naloxone; Prostaglandin Antagonists; Prostaglandins; Rabbits; Rats; Receptors, Drug; Sodium; Stimulation, Chemical | 1974 |
Drug therapy: analgetic drugs--the potent analgetics.
Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Methotrimeprazine; Morphinans; Morphine; Nalorphine; Narcotic Antagonists; Nausea; Pain; Pentazocine; Psychopharmacology; Respiration; Substance-Related Disorders; Urinary Tract; Vomiting | 1972 |
Toxicological findings in fatal poisonings.
Topics: 1-Propanol; Alcoholic Intoxication; Amphetamine; Carbon Monoxide Poisoning; Chloral Hydrate; Chlordiazepoxide; Dextropropoxyphene; Diazepam; Ethchlorvynol; Glutethimide; Heroin; Humans; Meprobamate; Methadone; Methanol; Morphine; Orphenadrine; Paraldehyde; Pentazocine; Phenothiazines; Phenytoin; Poisoning; Quinine; Salicylates; Toxicology; Tranquilizing Agents | 1973 |
In search of the opiate receptor.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Chromatography, Affinity; Cyclopropanes; Indicators and Reagents; Intestines; Levorphanol; Methadone; Morphinans; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentanols; Rats; Receptors, Drug; Tritium | 1973 |
Editorial: Analgesia in myocardial infarction.
Topics: Analgesia; Analgesics; Animals; Blood Pressure; Cyclizine; Heart Arrest; Heroin; Humans; Injections, Intravenous; Methadone; Morphine; Myocardial Infarction; Nausea; Pain; Pentazocine; Pulmonary Circulation; Respiration; Shock, Cardiogenic; Spirometry; Vomiting | 1974 |
Effects of narcotics and narcotic antagonists on operant behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Chlorpromazine; Columbidae; Conditioning, Operant; Cyclazocine; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Tolerance; Humans; Methadone; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Reinforcement Schedule; Substance Withdrawal Syndrome | 1973 |
Drug screening.
Topics: Amphetamine; Barbiturates; Bromides; Cocaine; Codeine; Drug Stability; Ethchlorvynol; Fluorometry; Glutethimide; Hemagglutination Inhibition Tests; Humans; Meprobamate; Methadone; Methods; Morphine; Pharmaceutical Preparations; Phenothiazines; Quinine; Salicylates | 1973 |
Stereochemical factors and receptor interactions associated with narcotic analgesics.
Topics: Chemistry, Pharmaceutical; Dextropropoxyphene; Humans; Methadone; Morphine; Sensory Receptor Cells | 1966 |
Biochemical reactions between opiate receptor binding and inhibition of neurotransmission.
Topics: Adenylyl Cyclases; Animals; Brain Chemistry; Calcium; Calmodulin; Etorphine; Humans; Methadone; Molecular Weight; Morphine; Narcotics; Nerve Endings; Nerve Tissue Proteins; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Phosphorylation; Protein Binding; Protein Kinases; Receptors, Opioid; Synaptic Transmission | 1984 |
[Treatment of opiate withdrawal syndromes (historical review)].
Topics: Antipsychotic Agents; Clonidine; Drug Evaluation; History, 19th Century; History, 20th Century; Humans; Methadone; Methadyl Acetate; Morphine; Narcotic Antagonists; Phenothiazines; Substance Withdrawal Syndrome | 1984 |
GC/MS assays for abused drugs in body fluids.
Topics: Amphetamines; Chromatography, Gas; Cocaine; Diazepam; Dronabinol; Humans; Mass Spectrometry; Mescaline; Methadone; Methaqualone; Morphine; Pharmaceutical Preparations; Phencyclidine; Substance-Related Disorders | 1980 |
Behavioral effects of prenatal exposure to opiates.
Topics: Age Factors; Animals; Animals, Suckling; Behavior, Animal; Female; Heroin; Humans; Methadone; Mice; Morphine; Narcotics; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Substance Withdrawal Syndrome; Weaning | 1983 |
Male mediated drug effects on offspring.
Topics: Animals; Birth Weight; Fathers; Female; Humans; Litter Size; Male; Methadone; Morphine; Pregnancy; Rats; Reproduction; Time Factors | 1980 |
Current management of the neonatal abstinence syndrome: a critical analysis of the evidence.
Topics: Analgesics, Opioid; Anticonvulsants; Antipsychotic Agents; Chlorpromazine; Clinical Trials as Topic; Clonidine; Diazepam; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; MEDLINE; Methadone; Morphine; Neonatal Abstinence Syndrome; Opium; Parasympatholytics; Phenobarbital; Sympatholytics | 1997 |
[Treatment of pain in oncology].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Dissociative; Diphosphonates; Fentanyl; Humans; Ketamine; Methadone; Morphine; Neoplasms; Pain; Pamidronate; Suppositories; Tramadol | 1997 |
Opioid rotation for cancer pain: rationale and clinical aspects.
Topics: Analgesics, Opioid; Fentanyl; Humans; Hydromorphone; Methadone; Morphine; Narcotics; Neoplasms; Pain | 1999 |
Opioid switch to oral methadone in cancer pain.
Topics: Administration, Oral; Analgesics, Opioid; Combined Modality Therapy; Cross-Sectional Studies; Dose-Response Relationship, Drug; Humans; Methadone; Morphine; Neoplasms; Pain; Receptors, N-Methyl-D-Aspartate | 2000 |
[Treatment of pain in cancer with systemically administered opioids].
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Administration Schedule; Humans; Infusion Pumps; Methadone; Morphine; Neoplasms; Netherlands; Oxycodone; Pain; Palliative Care; Practice Guidelines as Topic; World Health Organization | 2001 |
Strategies for the treatment of cancer pain in the new millennium.
Topics: Analgesics, Opioid; Cannabinoids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methadone; Morphine; Neoplasms; Nicotine; Pain | 2001 |
Opioid tolerance in neonates: a state-of-the-art review.
Topics: Analgesics, Opioid; Child Development; Drug Tolerance; Humans; Infant, Newborn; Methadone; Morphine; Protein Kinase C; Receptors, Cyclic AMP; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
Treatment of neonatal abstinence syndrome with breast milk containing methadone.
Topics: Breast Feeding; Drug Administration Schedule; Female; Humans; Infant, Newborn; Labor, Obstetric; Methadone; Milk, Human; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Prenatal Care | 2002 |
The use of methadone for cancer pain.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Biological Availability; Child; Clinical Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Costs; Drug Industry; Drug Information Services; Drug Interactions; Health Knowledge, Attitudes, Practice; Humans; Information Dissemination; Metabolic Clearance Rate; Methadone; Morphine; Neoplasms; Pain; Palliative Care; Patient Selection; Treatment Outcome | 2002 |
Opioids, immunology, and host defenses of intravenous drug abusers.
Topics: Animals; Heroin; Humans; Immunity, Cellular; Methadone; Morphine; Narcotics; Prevalence; Substance Abuse, Intravenous; United States | 2002 |
Intrathecal therapy for chronic pain.
Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Injections, Spinal; Ketamine; Methadone; Morphine; Narcotics; Neoplasms; Pain; Patient Selection; Receptors, N-Methyl-D-Aspartate | 2001 |
Treatment of neonatal abstinence syndrome.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Heroin; Humans; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Seizures; Sucking Behavior | 2003 |
From morphine clinics to buprenorphine: regulating opioid agonist treatment of addiction in the United States.
Topics: Analgesics, Opioid; Behavior, Addictive; Buprenorphine; Humans; Methadone; Morphine; Opioid-Related Disorders; Substance Abuse Treatment Centers; United States; United States Food and Drug Administration | 2003 |
ANTITUSSIVE DRUGS.
Topics: Antipsychotic Agents; Antitussive Agents; Chemistry, Pharmaceutical; Codeine; Cough; Dextromoramide; Drug Therapy; Humans; Meperidine; Methadone; Morphine; Pharmacology; Phenothiazines; Phenylacetates; Piperazines; Piperidines; Research; Thiophenes | 1963 |
THE CLINICAL EVALUATION OF MORPHINE AND ITS SUBSTITUTES AS ANALGESICS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Biomedical Research; Codeine; Cyclazocine; Dextromoramide; Dextropropoxyphene; Heroin; Humans; Hydromorphone; Isonipecotic Acids; Meperidine; Methadone; Methotrimeprazine; Morphine; Nalorphine; Narcotic Antagonists; Oxymorphone; Pentazocine; Phenazocine; Substance-Related Disorders; Toxicology | 1964 |
Morphine is not the only analgesic in palliative care: literature review.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Ketamine; Methadone; Morphine; Neoplasms; Pain; Palliative Care | 2004 |
Methadone for cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Controlled Trials as Topic | 2004 |
Interpretation of opioid levels: comparison of levels during chronic pain therapy to levels from forensic autopsies.
Topics: Analgesics, Opioid; Autopsy; Fentanyl; Humans; Methadone; Morphine; Oxycodone; Pain, Intractable | 2005 |
Justification for routine screening of pharmaceutical products in immune function tests: a review of the recommendations of Putman et al. (2003).
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Buprenorphine; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Guidelines as Topic; Humans; Immune System Diseases; Immunity; Methadone; Morphine; Narcotics; Salmeterol Xinafoate | 2005 |
Innovations in agonist maintenance treatment of opioid-dependent patients.
Topics: Buprenorphine; Controlled Clinical Trials as Topic; Delayed-Action Preparations; Heroin; Humans; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Quality of Life | 2006 |
Pharmacological approaches to the management of pain in the neonatal intensive care unit.
Topics: Analgesics; Analgesics, Opioid; Female; Humans; Infant, Newborn; Infant, Premature; Intensive Care Units, Neonatal; Ketamine; Male; Methadone; Morphine; Pain; Pain Management; Treatment Outcome | 2007 |
The management of pain in children with life-limiting illnesses.
Topics: Analgesics, Opioid; Child; Chronic Disease; Codeine; Fentanyl; Humans; Hydromorphone; Ketamine; Methadone; Morphine; Nociceptors; Oxycodone; Pain; Pain Measurement; Severity of Illness Index | 2007 |
Methadone for cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Controlled Trials as Topic | 2007 |
Effectiveness of opioids in the treatment of chronic non-cancer pain.
Topics: Analgesics, Opioid; Drug Administration Schedule; Fentanyl; Humans; Methadone; Morphine; Oxycodone; Oxymorphone; Pain; Quality of Life; Time Factors; Tramadol | 2008 |
Equianalgesia: applying evidence-based practice guidelines.
Topics: Analgesia; Analgesics, Opioid; Codeine; Drug Monitoring; Evidence-Based Medicine; Humans; Hydromorphone; Methadone; Morphine; Neoplasms; Nurse's Role; Nursing Assessment; Oncology Nursing; Pain; Practice Guidelines as Topic; Therapeutic Equivalency; Treatment Outcome | 2008 |
Pediatric palliative care: use of opioids for the management of pain.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Child; Delayed-Action Preparations; Fentanyl; Humans; Hydromorphone; Methadone; Morphine; Narcotics; Pain; Palliative Care | 2009 |
Morphine to methadone conversion: an interpretation of published data.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Pain; Palliative Care; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2011 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; Milk, Human; Morphine; Narcotic Antagonists; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pain Management; Patient Dropouts; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Randomized Controlled Trials as Topic; Substance Abuse Detection; Treatment Outcome | 2012 |
Neonatal abstinence syndrome: therapeutic interventions.
Topics: Female; Humans; Infant; Infant Welfare; Infant, Newborn; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Nursing Assessment; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Severity of Illness Index | 2013 |
Pharmacologic management of neonatal abstinence syndrome in a community hospital.
Topics: Analgesics, Opioid; Female; Florida; Humans; Infant, Newborn; Intensive Care, Neonatal; Length of Stay; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Practice Guidelines as Topic; Pregnancy; Pregnancy Complications | 2013 |
Management of neonatal abstinence syndrome from opioids.
Topics: Analgesics, Opioid; Buprenorphine; Feeding Methods; Humans; Infant Care; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Pacifiers; Treatment Outcome | 2013 |
Transdermal fentanyl for cancer pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Controlled Trials as Topic | 2013 |
Maintenance agonist treatments for opiate-dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Randomized Controlled Trials as Topic | 2013 |
Behavioral effects of perinatal opioid exposure.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Female; Humans; Illicit Drugs; Infant, Newborn; Male; Maternal Exposure; Maze Learning; Mental Disorders; Methadone; Mice; Morphine; Pain; Pregnancy; Rats; Sex Factors; Stress, Physiological | 2014 |
[Analgesic management of acute pain in patients receiving methadone or buprenorphine].
Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Drug Tolerance; Drug Users; Humans; Methadone; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Pain Management | 2015 |
Antipsychotic-related fatal poisoning, England and Wales, 1993-2013: impact of the withdrawal of thioridazine.
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Drug Recalls; England; Heroin; Humans; Methadone; Morphine; Olanzapine; Poisoning; Quetiapine Fumarate; Thioridazine; Wales | 2016 |
Pharmacotherapy for Neonatal Abstinence Syndrome: Choosing the Right Opioid or No Opioid at All.
Topics: Analgesics; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Phenobarbital | 2016 |
Neonatal Abstinence Syndrome.
Topics: Female; Humans; Incidence; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2016 |
Methadone for cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Humans; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Controlled Trials as Topic | 2017 |
[Treatment of acute pain in opioid addicts].
Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Pain Management; Pain Measurement; Professional-Patient Relations | 2017 |
Association of Rooming-in With Outcomes for Neonatal Abstinence Syndrome: A Systematic Review and Meta-analysis.
Topics: Analgesics, Opioid; Drug Utilization; Hospital Costs; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Rooming-in Care | 2018 |
Methadone as anticancer treatment: hype, hope, or hazard? : A series of case reports and a short review of the current literature and recommendations of the societies.
Topics: Analgesics, Opioid; Austria; Female; Germany; Humans; Methadone; Middle Aged; Morphine; Neoplasms; Pain Management | 2018 |
Neonatal Abstinence Syndrome: Advances in Diagnosis and Treatment.
Topics: Acupuncture Therapy; Analgesics; Breast Feeding; Buprenorphine; Clonidine; Female; Humans; Infant, Newborn; Methadone; Morphine; Mothers; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Rooming-in Care | 2018 |
[Opioid switch and change of route of administration in cancer patients treated by morphine].
Topics: Administration, Oral; Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Drug Substitution; Fentanyl; France; Humans; Hydromorphone; Injections, Intravenous; Injections, Subcutaneous; Methadone; Morphine; Oxycodone; Phenols; Tapentadol | 2018 |
Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; United States | 2018 |
Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS).
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome | 2019 |
Slow release oral morphine versus methadone for the treatment of opioid use disorder.
Topics: Administration, Oral; Delayed-Action Preparations; Humans; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic | 2019 |
Comparative effectiveness of opioid replacement agents for neonatal opioid withdrawal syndrome: a systematic review and meta-analysis.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment | 2019 |
Methadone versus morphine treatment outcomes in neonatal abstinence syndrome: A meta-analysis.
Topics: Analgesics, Opioid; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Treatment Outcome | 2019 |
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Intensive Care Units, Neonatal; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Nurseries, Hospital; Opiate Substitution Treatment; Opioid-Related Disorders; Parents; Phenobarbital; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rooming-in Care; Severity of Illness Index; Treatment Outcome | 2019 |
Why equianalgesic tables are only part of the answer to equianalgesia.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Dosage Calculations; Humans; Methadone; Morphine; Opioid Epidemic; Pain; Pain Management; Prescription Drug Misuse | 2020 |
Maintenance agonist treatments for opiate-dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Dropouts; Pregnancy; Pregnancy Complications; Randomized Controlled Trials as Topic | 2020 |
Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome?
Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Antipsychotic Agents; Arrhythmias, Cardiac; Autopsy; Cause of Death; Consciousness; Drug Interactions; Drug Overdose; Female; Forensic Toxicology; Humans; Hypotension; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Quetiapine Fumarate; Respiratory Insufficiency; Risk Assessment; Risk Factors | 2021 |
Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches.
Topics: Buprenorphine; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Methadone; Models, Biological; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders | 2021 |
Methadone: applications in pediatric anesthesiology and critical care medicine.
Topics: Analgesics, Opioid; Anesthesiology; Child; Critical Care; Humans; Methadone; Morphine | 2021 |
Opioid treatment for opioid withdrawal in newborn infants.
Topics: Buprenorphine; Chlorpromazine; Clonidine; Diazepam; Humans; Hypnotics and Sedatives; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Opium; Phenobarbital; Randomized Controlled Trials as Topic | 2021 |
Psychosis after buprenorphine, heroin, methadone, morphine, oxycodone, and tramadol withdrawal: a systematic review.
Topics: Analgesics, Opioid; Buprenorphine; Heroin; Humans; Methadone; Morphine; Oxycodone; Psychotic Disorders; Substance Withdrawal Syndrome; Tramadol | 2021 |
Methadone Switching for Cancer Pain: A New Classification of Initiation Protocols, Based on a Critical Literature Review.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Pain; Randomized Controlled Trials as Topic | 2021 |
Relative effectiveness of medications for opioid-related disorders: A systematic review and network meta-analysis of randomized controlled trials.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Morphine; Naltrexone; Network Meta-Analysis; Opioid-Related Disorders; Randomized Controlled Trials as Topic | 2022 |
Monitoring Prenatal Exposure to Buprenorphine and Methadone.
Topics: Analgesics, Opioid; Buprenorphine; Drug Monitoring; Female; Hair; Humans; Meconium; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Umbilical Cord | 2020 |
115 trial(s) available for methadone and morphine
| Article | Year |
|---|---|
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors | 1976 |
Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.
Topics: Adult; Blood Pressure; Buprenorphine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Euphoria; Humans; Male; Methadone; Middle Aged; Morphinans; Morphine; Naloxone; Narcotics; Pulse; Pupil; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Methadyl acetate and methadone. An open comparison.
Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Morphine; Substance Withdrawal Syndrome | 1977 |
Analgesia in clinical practice.
Topics: Acetaminophen; Analgesia; Analgesics; Aspirin; Clinical Trials as Topic; Drug Interactions; Heroin; Humans; Methadone; Morphine; Nalorphine; Naloxone; Pentazocine | 1977 |
Methadyl acetate versus methadone: the experience of one hospital.
Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Morphine; Patient Dropouts | 1977 |
Preliminary observations with acute and chronic methadone and 1-alpha-acetylmethadol administration in humans.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Tolerance; Female; Humans; Male; Methadone; Methadyl Acetate; Morphine; Substance-Related Disorders; Time Factors | 1976 |
Summary of Veterans Administration Phase II cooperative study for LAAM and methadone.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Middle Aged; Morphine; Patient Dropouts; Self Administration; United States; United States Department of Veterans Affairs | 1976 |
Propranolol in the treatment of opiate dependence -- a controlled study.
Topics: Adolescent; Adult; Clinical Trials as Topic; Euphoria; Female; Heart Rate; Humans; Male; Methadone; Morphine; Morphine Dependence; Narcotic Antagonists; Placebos; Propranolol; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intravenous; Methadone; Morphine; Nausea; Oxygen; Pain Measurement; Pain, Postoperative; Premedication; Vomiting | 1992 |
Comparison of morphine and methadone for prevention of postoperative pain in 3- to 7-year-old children.
Topics: Algorithms; Analysis of Variance; Child; Child, Preschool; Double-Blind Method; Drug Evaluation; Female; Humans; Intraoperative Care; Male; Methadone; Morphine; Pain Measurement; Pain, Postoperative; Prospective Studies | 1991 |
Discordance between self-report and behavioral pain measures in children aged 3-7 years after surgery.
Topics: Behavior; Child; Child, Preschool; Double-Blind Method; Humans; Interview, Psychological; Intraoperative Care; Methadone; Morphine; Pain Measurement; Pain, Postoperative | 1990 |
Does intravenous methadone provide longer lasting analgesia than intravenous morphine? A randomized, double-blind study.
Topics: Adult; Aged; Analgesics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intravenous; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable | 1989 |
Intrathecal methadone and morphine for postoperative analgesia: a comparison of the efficacy, duration, and side effects.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Humans; Injections, Spinal; Male; Methadone; Middle Aged; Morphine; Pain, Postoperative; Random Allocation; Time Factors | 1989 |
A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer.
Topics: Administration, Oral; Aged; Biological Availability; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Humans; Infusions, Parenteral; Metabolic Clearance Rate; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Random Allocation | 1986 |
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome | 1986 |
A randomized study on oral administration of morphine and methadone in the treatment of cancer pain.
Topics: Administration, Oral; Clinical Trials as Topic; Female; Humans; Male; Methadone; Morphine; Neoplasms; Pain, Intractable; Random Allocation | 1986 |
Comparison of intravenously administered methadone, morphine and heroin.
Topics: Adult; Double-Blind Method; Euphoria; Heroin; Humans; Injections, Intravenous; Male; Methadone; Morphine; Pupil; Surveys and Questionnaires | 1986 |
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Methadone; Middle Aged; Morphine; Pain; Postoperative Period; Time Factors | 1986 |
Effects of diamorphine, methadone, morphine, and pentazocine in patients with suspected acute myocardial infarction.
Topics: Acute Disease; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Heroin; Humans; Injections, Intravenous; Male; Methadone; Middle Aged; Morphine; Myocardial Infarction; Pain; Pentazocine; Respiration | 1969 |
Studies on the relationship between 5-hydroxytryptamine turnover in brain and tolerance and physical dependence in mice.
Topics: Animals; Aspirin; Brain; Cyclazocine; Drug Tolerance; Fenclonine; Humans; Levorphanol; Male; Methadone; Mice; Morphinans; Morphine; Morphine Dependence; Nalorphine; Pargyline; Pentazocine; Phenylalanine; Physostigmine; Placebos; Serotonin; Substance Withdrawal Syndrome | 1971 |
Methadone--a reevaluation.
Topics: Administration, Oral; Affect; Blood Pressure; Body Temperature; Dose-Response Relationship, Drug; Drug Tolerance; Electroencephalography; Humans; Injections, Subcutaneous; Male; Methadone; Morphine; Pituitary Function Tests; Pupil; Respiration; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders | 1973 |
Levomethadyl in maintenance treatment of opiate dependence.
Topics: Adult; Alcohols; Amphetamine; Barbiturates; Benzene Derivatives; Heroin; Humans; Injections, Intravenous; Male; Methadone; Methylamines; Morphine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1972 |
Post-operative pain relief: comparison of methadone and morphine when used concurrently with nitrous-oxide analgesia.
Topics: Humans; Methadone; Morphine; Nitrous Oxide; Pain; Postoperative Care | 1966 |
Comparison of four narcotic analgesics for extradural analgesia.
Topics: Adult; Aged; Analgesics, Opioid; Epidural Space; Female; Fentanyl; Hemodynamics; Humans; Injections; Male; Meperidine; Methadone; Middle Aged; Morphine; Pain, Postoperative; Respiration; Time Factors | 1982 |
Postoperative analgesia for Caesarean section using epidural methadone.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Bupivacaine; Cesarean Section; Double-Blind Method; Epidural Space; Female; Humans; Injections; Methadone; Morphine; Pain, Postoperative; Pregnancy; Prospective Studies; Retrospective Studies | 1984 |
Plasma levels and analgesia following deltoid and gluteal injections of methadone and morphine.
Topics: Adult; Analgesics; Biological Availability; Female; Humans; Injections, Intramuscular; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Postoperative | 1983 |
Methadone and morphine in depression [proceedings].
Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Methadone; Middle Aged; Morphine | 1981 |
Morphinelike arousal by methadone during sleep.
Topics: Adult; Arousal; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Morphine; Muscle Contraction; Opioid-Related Disorders; Random Allocation; Sleep; Sleep Initiation and Maintenance Disorders; Time Factors | 1981 |
A comparison of intraoperative morphine sulfate and methadone hydrochloride on postoperative visual analogue scale pain scores and narcotic requirements.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Intraoperative Care; Male; Methadone; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative | 1995 |
Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Cesarean Section; Double-Blind Method; Female; Heroin; Humans; Hypoxia; Incidence; Methadone; Morphine; Nausea; Oxygen; Pain Measurement; Pain, Postoperative; Pregnancy; Prochlorperazine; Pruritus; Time Factors | 1993 |
Ventilatory effects of morphine, pethidine and methadone in children.
Topics: Child; Child, Preschool; Depression, Chemical; Female; Humans; Male; Meperidine; Methadone; Morphine; Oxygen; Pain, Postoperative; Respiration; Tidal Volume; Time Factors | 1993 |
Comments on Ripamonti et al., Pain, 70 (1997) 109-115.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Pain, Intractable | 1997 |
Overnight hospitalization after radical prostatectomy: the impact of two clinical pathways on patient satisfaction, length of hospitalization, and morbidity.
Topics: Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, Epidural; Humans; Length of Stay; Male; Methadone; Middle Aged; Morphine; Patient Satisfaction; Prostatectomy; Treatment Outcome | 1998 |
Substitution with buprenorphine in methadone- and morphine sulfate-dependent patients. Preliminary results.
Topics: Adult; Buprenorphine; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Morphine; Narcotics; Opioid-Related Disorders | 1998 |
Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home.
Topics: Adult; Aged; Analgesics, Opioid; Female; Home Care Services; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable; Prospective Studies | 1998 |
Methadone titration in opioid-resistant cancer pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Administration Schedule; Drug Resistance; Drug Tolerance; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Pain Measurement; Therapeutic Equivalency | 1999 |
Comparison of methadone and slow-release morphine maintenance in pregnant addicts.
Topics: Adolescent; Adult; Delayed-Action Preparations; Female; Humans; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Pregnancy; Substance-Related Disorders | 1999 |
Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain.
Topics: Adult; Aged; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neuralgia; Pain | 1999 |
The Swiss heroin trials. Scientifically sound?
Topics: Adult; Drug Prescriptions; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Outcome and Process Assessment, Health Care; Research Design; Switzerland | 1999 |
Slow-release morphine was not more effective than methadone in reducing neonatal abstinence syndrome.
Topics: Adult; Delayed-Action Preparations; Female; Humans; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Pregnancy | 2000 |
Patterns of opiate use in a heroin maintenance programme.
Topics: Adult; Age Factors; Anti-Anxiety Agents; Clorazepate Dipotassium; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Morphine; Narcotics; Recurrence; Risk Factors | 2000 |
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Prospective Studies | 2001 |
Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine.
Topics: Acute Disease; Adult; Analgesics, Opioid; Cold Temperature; Drug Interactions; Drug Tolerance; Electric Stimulation; Female; Humans; Hyperalgesia; Injections, Intravenous; Male; Methadone; Morphine; Nociceptors; Pain Threshold | 2001 |
[Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases].
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Pregnancy; Pregnancy Complications; Prenatal Care; Prognosis; Prospective Studies; Substance-Related Disorders | 2001 |
Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain.
Topics: Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Hydromorphone; Levorphanol; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Patient Satisfaction; Prospective Studies | 2002 |
Postoperative pain relief after hepatic resection in cirrhotic patients: the efficacy of a single small dose of ketamine plus morphine epidurally.
Topics: Acetaminophen; Adult; Aged; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Carcinoma, Hepatocellular; Female; Humans; Ketamine; Liver; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Methadone; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Prospective Studies | 2003 |
Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Male; Methadone; Middle Aged; Morphine; Narcotic Antagonists; Opioid-Related Disorders | 2003 |
Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence.
Topics: Adult; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; Opioid-Related Disorders; Patient Satisfaction; Treatment Outcome | 2004 |
Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre.
Topics: Administration, Oral; Adult; Humans; Methadone; Middle Aged; Morphine; Narcotics; Opioid-Related Disorders; Opium; Substance Withdrawal Syndrome | 2004 |
Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops.
Topics: Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opium; Pregnancy; Prenatal Exposure Delayed Effects | 2005 |
The effect of intra-articular methadone on postoperative pain following anterior cruciate ligament reconstruction.
Topics: Adult; Analgesics, Opioid; Anterior Cruciate Ligament; Arthroscopy; Female; Humans; Injections, Intra-Articular; Knee Joint; Male; Methadone; Morphine; Pain Measurement; Pain, Postoperative; Prospective Studies | 2005 |
Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Humans; Methadone; Morphine; Opioid-Related Disorders; Pregnancy; Substance Withdrawal Syndrome | 2005 |
Driving capacity of patients treated with methadone and slow-release oral morphine.
Topics: Adult; Analgesics, Opioid; Austria; Automobile Driving; Humans; Methadone; Morphine; Opioid-Related Disorders; Psychomotor Performance | 2005 |
Comparative study of the effectiveness of slow-release morphine and methadone for opioid maintenance therapy.
Topics: Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Methadone; Middle Aged; Morphine; Narcotic Antagonists; Opioid-Related Disorders; Time Factors; Treatment Outcome | 2005 |
Opioid addicts at admission vs. slow-release oral morphine, methadone, and sublingual buprenorphine maintenance treatment participants.
Topics: Adult; Austria; Buprenorphine; Delayed-Action Preparations; Female; Humans; Male; Methadone; Morphine; Opioid-Related Disorders; Quality of Life; Substance Abuse Treatment Centers | 2006 |
Methadone maintenance patients are cross-tolerant to the antinociceptive effects of very high plasma morphine concentrations.
Topics: Adult; Analgesics; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Drug Tolerance; Female; Humans; Injections, Intravenous; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Pain Threshold; Placebo Effect; Treatment Outcome | 2006 |
Analgesic effects of subarachnoidally administered hyperbaric opioids in horses.
Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; Cross-Over Studies; Female; Horse Diseases; Horses; Injections, Spinal; Male; Methadone; Morphine; Pain | 2006 |
Mast cell mediator tryptase levels after inhalation or intravenous administration of high doses pharmaceutically prepared heroin.
Topics: Administration, Inhalation; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Heroin; Humans; Injections, Intravenous; Male; Methadone; Middle Aged; Morphine; Tryptases | 2006 |
Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study.
Topics: Aged; Analgesics, Opioid; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Long QT Syndrome; Male; Methadone; Middle Aged; Morphine; Prospective Studies; Risk Assessment; Risk Factors | 2006 |
Hair analysis underestimates heroin use in prisoners.
Topics: Adolescent; Adult; Catchment Area, Health; Female; Follow-Up Studies; Hair; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; New South Wales; Prisoners; Prisons; Surveys and Questionnaires; Treatment Outcome | 2006 |
Management of neonatal abstinence syndrome in neonates born to opioid maintained women.
Topics: Adult; Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Patient Selection; Phenobarbital; Pregnancy; Pregnancy Complications | 2007 |
Methadone in the treatment of pain and terminal delirum in advanced cancer patients.
Topics: Aged; Analgesics, Opioid; Delirium; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Neuropsychological Tests; Oxycodone; Pain; Pain Measurement; Palliative Care; Treatment Outcome | 2005 |
Long term methadone for chronic pain: a pilot study of pharmacokinetic aspects.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Pain, Intractable; Pilot Projects; Time; Treatment Outcome | 2007 |
Assessing the trade-offs between crossover and parallel group designs in sleep research.
Topics: Adult; Computer Graphics; Cross-Over Studies; Data Collection; Data Interpretation, Statistical; Female; Humans; Male; Mathematical Computing; Methadone; Morphine; Narcotics; Polysomnography; Research Design; Sleep | 2006 |
The effect of opioids on sleep architecture.
Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; Opioid-Related Disorders; Pain; Polysomnography; Sleep Apnea, Obstructive; Sleep Stages; Sleep, REM; Wakefulness | 2007 |
Quality of life in patients receiving opioid maintenance therapy. A comparative study of slow-release morphine versus methadone treatment.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Prospective Studies; Quality of Life | 2008 |
Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Aged; Analgesia; Analgesics, Opioid; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable; Patient Satisfaction; Prospective Studies; Quality of Life; Treatment Outcome | 2008 |
The role of methadone in opioid rotation-a Polish experience.
Topics: Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Poland; Severity of Illness Index; Treatment Outcome; Young Adult | 2009 |
Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs.
Topics: Acepromazine; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Body Temperature; Butorphanol; Cross-Over Studies; Dog Diseases; Dogs; Dopamine Antagonists; Drug Therapy, Combination; Hypnotics and Sedatives; Male; Methadone; Morphine; Tramadol; Vomiting | 2009 |
Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Humans; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Prospective Studies; Young Adult | 2010 |
Comparison of the cardio-respiratory effects of methadone and morphine in conscious dogs.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Cardiovascular System; Dogs; Electrocardiography; Female; Hemodynamics; Infusions, Intravenous; Male; Methadone; Morphine; Respiratory System | 2009 |
A double-blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow-release oral morphine versus methadone in opioid-dependent in-patients willing to undergo detoxification.
Topics: Adult; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome | 2009 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; Length of Stay; Logistic Models; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2010 |
How to switch from morphine or oxycodone to methadone in cancer patients? a randomised clinical phase II trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Substitution; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Oxycodone; Pain; Patient Dropouts; Prospective Studies | 2011 |
Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women.
Topics: Adult; Austria; Birth Weight; Buprenorphine; Double-Blind Method; Female; Gestational Age; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, Third; Prospective Studies; Time Factors; Young Adult | 2011 |
Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Morphine Derivatives; Neoplasms; Oxycodone; Pain; Palliative Care; Patient Dropouts | 2012 |
Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Cross-Sectional Studies; Female; Genetic Association Studies; Heroin Dependence; Humans; Hypnotics and Sedatives; Libido; Male; Methadone; Morphine; Opiate Substitution Treatment; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; Sexual Dysfunctions, Psychological; Sleep Initiation and Maintenance Disorders; Substance Abuse Detection; Substance Abuse Treatment Centers; Taiwan | 2012 |
Feasibility of double-blind clinical trials with oral diacetylmorphine: a randomized controlled phase II study in an inpatient setting.
Topics: Administration, Oral; Adult; Behavior, Addictive; Delayed-Action Preparations; Double-Blind Method; Feasibility Studies; Female; Heroin; Heroin Dependence; Humans; Inpatients; Male; Methadone; Morphine; Opiate Substitution Treatment; Physicians; Pilot Projects; Psychiatric Status Rating Scales | 2012 |
Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment.
Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Analgesics, Opioid; Central Nervous System Stimulants; Dextromethorphan; Double-Blind Method; Female; Heroin Dependence; Humans; Inflammation; Interleukin-8; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Secondary Prevention; Substance Abuse Detection; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication.
Topics: Adolescent; Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Length of Stay; Linear Models; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Risk Factors; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Smoking; Young Adult | 2012 |
Neonatal neurobehavior effects following buprenorphine versus methadone exposure.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant Behavior; Infant, Newborn; Linear Models; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Severity of Illness Index; Young Adult | 2012 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Educational Status; Ethnicity; Female; Humans; Linear Models; Methadone; Morphine; Narcotics; Patient Dropouts; Pregnancy; Pregnancy Complications; Socioeconomic Factors; Substance Withdrawal Syndrome | 2013 |
Bioavailability of morphine, methadone, hydromorphone, and oxymorphone following buccal administration in cats.
Topics: Administration, Buccal; Analgesics, Opioid; Animals; Biological Availability; Cats; Female; Hydromorphone; Methadone; Morphine; Oxymorphone | 2014 |
Maintenance treatment for opioid dependence with slow-release oral morphine: a randomized cross-over, non-inferiority study versus methadone.
Topics: Administration, Oral; Adult; Codeine; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Maintenance Chemotherapy; Male; Medication Adherence; Methadone; Middle Aged; Morphine; Morphine Derivatives; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome | 2014 |
Methadone patient-controlled analgesia for postoperative pain: a randomized, controlled, double-blind study.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Arthroplasty, Replacement, Hip; Double-Blind Method; Female; Humans; Male; Methadone; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative | 2014 |
Cardiorespiratory, sedative and antinociceptive effects of dexmedetomidine alone or in combination with methadone, morphine or tramadol in dogs.
Topics: Analgesia; Analgesics; Animals; Blood Pressure; Body Temperature; Cross-Over Studies; Deep Sedation; Dexmedetomidine; Dogs; Drug Therapy, Combination; Female; Heart; Heart Rate; Male; Methadone; Morphine; Respiratory Physiological Phenomena; Respiratory Rate; Tramadol | 2014 |
Safety and tolerability of slow-release oral morphine versus methadone in the treatment of opioid dependence.
Topics: Administration, Oral; Adult; Cross-Over Studies; Delayed-Action Preparations; Europe; Female; Humans; International Cooperation; Male; Methadone; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome | 2014 |
Methadone versus morphine for treatment of neonatal abstinence syndrome: a prospective randomized clinical trial.
Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Double-Blind Method; Female; Gestational Age; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Prospective Studies; Treatment Outcome | 2015 |
Mental symptoms and drug use in maintenance treatment with slow-release oral morphine compared to methadone: results of a randomized crossover study.
Topics: Administration, Oral; Adult; Alcohol Drinking; Behavioral Symptoms; Cross-Over Studies; Delayed-Action Preparations; Female; Germany; Humans; Male; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Satisfaction; Substance-Related Disorders; Switzerland; Treatment Outcome; Young Adult | 2015 |
Self-reported cravings for heroin and cocaine during maintenance treatment with slow-release oral morphine compared with methadone: a randomized, crossover clinical trial.
Topics: Adult; Cocaine-Related Disorders; Cross-Over Studies; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; Opiate Substitution Treatment; Substance Withdrawal Syndrome; Surveys and Questionnaires; Treatment Outcome; Young Adult | 2015 |
A placebo-controlled trial of dextromethorphan as an adjunct in opioid-dependent patients undergoing methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Dextromethorphan; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Humans; Interleukin-6; Interleukin-8; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Retention, Psychology; Time Factors; Transforming Growth Factor beta1; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs.
Topics: Acepromazine; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Dogs; Female; Hysterectomy; Isoflurane; Methadone; Morphine; Ovariectomy; Premedication; Pulmonary Alveoli | 2016 |
Sedative and cardiopulmonary effects of xylazine alone or in combination with methadone, morphine or tramadol in sheep.
Topics: Animals; Cardiovascular System; Cross-Over Studies; Drug Interactions; Female; Hypnotics and Sedatives; Methadone; Morphine; Prospective Studies; Respiratory System; Sheep; Tramadol; Xylazine | 2016 |
Postoperative pain control in cats: clinical trials with pre-emptive lidocaine epidural co-administered with morphine or methadone.
Topics: Analgesics, Opioid; Anesthesia, General; Anesthetics, Local; Animals; Cats; Drug Administration Schedule; Drug Therapy, Combination; Female; Hysterectomy; Injections, Epidural; Lidocaine; Methadone; Morphine; Ovariectomy; Pain Measurement; Pain, Postoperative; Treatment Outcome | 2016 |
Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Ibogaine; Male; Methadone; Morphine; Nausea; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome | 2016 |
Behavioral and cardiopulmonary effects of dexmedetomidine alone and in combination with butorphanol, methadone, morphine or tramadol in conscious sheep.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Butorphanol; Deep Sedation; Dexmedetomidine; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Male; Methadone; Morphine; Respiratory Rate; Sheep; Tramadol | 2016 |
Comparison of medetomidine-morphine and medetomidine-methadone for sedation, isoflurane requirement and postoperative analgesia in dogs undergoing laparoscopy.
Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Combined; Animals; Cross-Over Studies; Dogs; Female; Isoflurane; Laparoscopy; Male; Medetomidine; Methadone; Morphine; Preanesthetic Medication; Propofol | 2017 |
Effect of morphine, methadone, hydromorphone or oxymorphone on the thermal threshold, following intravenous or buccal administration to cats.
Topics: Administration, Buccal; Administration, Intravenous; Analgesics, Opioid; Animals; Cats; Cross-Over Studies; Female; Hydromorphone; Methadone; Morphine; Oxymorphone; Pain Threshold | 2016 |
[Effects of morphine, butorphanol and levomethadone in different doses on thermal nociceptive thresholds in horses].
Topics: Analgesics; Animals; Butorphanol; Horse Diseases; Horses; Hot Temperature; Methadone; Morphine; Pain; Pain Measurement | 2017 |
Comparison of Safety and Efficacy of Methadone vs Morphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Clinical Trial.
Topics: Analgesics, Opioid; Double-Blind Method; Female; Humans; Infant, Newborn; Intention to Treat Analysis; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Treatment Outcome | 2018 |
The effect of methadone on postoperative quality of recovery in patients undergoing laparoscopic cholecystectomy: A prospective, randomized, double blinded, controlled clinical trial.
Topics: Adult; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Intravenous; Cholecystectomy, Laparoscopic; Female; Humans; Male; Methadone; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Prospective Studies; Remifentanil; Treatment Outcome; Young Adult | 2019 |
A preoperative single dose of methadone for moderate-to-severely painful surgery reduces postoperative morphine consumption.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia; Double-Blind Method; Female; Fentanyl; Humans; Length of Stay; Male; Methadone; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Preoperative Care | 2019 |
Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial.
Topics: Analgesics, Opioid; Female; Humans; Methadone; Morphine; Neoplasms; Pain Measurement; Pain, Postoperative | 2020 |
Neurodevelopmental Outcomes of Neonates Randomized to Morphine or Methadone for Treatment of Neonatal Abstinence Syndrome.
Topics: Female; Humans; Infant; Infant, Newborn; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Nervous System; Phenobarbital | 2020 |
Slow release oral morphine versus methadone for opioid use disorder in the fentanyl era (pRESTO): Protocol for a non-inferiority randomized clinical trial.
Topics: Adult; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Overdose; Equivalence Trials as Topic; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Satisfaction; Quality of Life; Young Adult | 2020 |
Methadone for postoperative analgesia: contribution of N-methyl-D-aspartate receptor antagonism: A randomised controlled trial.
Topics: Analgesia; Analgesics, Opioid; Double-Blind Method; Humans; Methadone; Morphine; Pain, Postoperative; Prospective Studies; Receptors, N-Methyl-D-Aspartate | 2020 |
Intra-operative methadone effect on quality of recovery compared with morphine following laparoscopic gastroplasty: a randomised controlled trial.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia Recovery Period; Double-Blind Method; Female; Gastroplasty; Humans; Intraoperative Period; Laparoscopy; Male; Methadone; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Postoperative Nausea and Vomiting; Treatment Outcome | 2021 |
Neonatal Abstinence Syndrome Severity Index Predicts 18-Month Neurodevelopmental Outcome in Neonates Randomized to Morphine or Methadone.
Topics: Analgesics, Opioid; Cluster Analysis; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Severity of Illness Index | 2020 |
Efficacy of methadone for the management of postoperative pain in laparoscopic cholecystectomy: A randomized clinical trial.
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Intravenous; Cholecystectomy, Laparoscopic; Double-Blind Method; Humans; Methadone; Middle Aged; Morphine; Pain Management; Pain Measurement; Pain, Postoperative; Treatment Outcome | 2021 |
A Randomized Controlled Trial Evaluating the Analgesic Effect of the Combination of Methadone With Morphine for Cancer Related Pain.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms | 2021 |
Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study.
Topics: Analgesics, Opioid; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Pilot Projects | 2022 |
Pragmatic, randomized, blinded trial to shorten pharmacologic treatment of newborns with neonatal opioid withdrawal syndrome (NOWS).
Topics: Analgesics, Opioid; Family; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Research Design | 2023 |
Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes.
Topics: Adult; Buprenorphine; Cocaine; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Maternal Behavior; Maternal-Fetal Exchange; Meconium; Methadone; Narcotic Antagonists; Neonatal Abstinence Syndrome; Nicotine; Opiate Alkaloids; Opioid-Related Disorders; Pregnancy; Smoking | 2008 |
Maternal methadone dose, placental methadone concentrations, and neonatal outcomes.
Topics: Analgesics, Opioid; Apgar Score; Birth Weight; Body Size; Cephalometry; Cocaine; Female; Gestational Age; Humans; Infant, Newborn; Maternal Exposure; Meconium; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Placenta; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimesters; Pyrrolidines; Tissue Distribution | 2011 |
Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meconium; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Placenta; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pyrrolidines; Umbilical Cord | 2011 |
986 other study(ies) available for methadone and morphine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
Topics: Calcium; Cell Degranulation; Cell Line; Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mast Cells; Molecular Docking Simulation; Molecular Probes; Molecular Structure; Nerve Tissue Proteins; Pyrazoles; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Structure-Activity Relationship | 2017 |
Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect.
Topics: Analgesics, Opioid; Animals; Body Temperature; Corpus Striatum; Cyclazocine; Haloperidol; Homovanillic Acid; Male; Methadone; Mice; Morphine; Pain; Pentazocine; Phenylacetates; Piperidines; Thebaine; Time Factors | 1976 |
Schedule-induced narcotic ingestion.
Topics: Analgesics, Opioid; Animals; Benzimidazoles; Conditioning, Operant; Diethylamines; Feeding Behavior; Food; Humans; Methadone; Morphine; Narcotics; Rats; Reinforcement Schedule; Reinforcement, Psychology; Self Mutilation; Time Factors; Water Deprivation | 1975 |
Effect of blockade of 5-hydroxytryptamine re-uptake on drug-induced antinociception in the rat.
Topics: Analgesics; Animals; Brain; Depression, Chemical; Male; Meperidine; Methadone; Morphine; Phenyl Ethers; Propylamines; Rats; Reaction Time; Serotonin | 1976 |
Interactions between narcotic analgesics and benzodiazepine derivatives on behavior in the mouse.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzodiazepines; Brain; Brain Chemistry; Dextroamphetamine; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Male; Methadone; Methods; Mice; Morphine; Motor Activity; Naloxone; Oxazepam; Reaction Time | 1976 |
Behavioral effects of narcotic analgesics administered alone or in combination with narcotic antagonists.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Drug Interactions; Electroshock; Haplorhini; Macaca fascicularis; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Time Factors | 1976 |
Effects of narcotic analgesics on serotonin metabolism in brain of rats and mice.
Topics: Analgesics, Opioid; Animals; Atropine; Brain; Drug Interactions; Fenclonine; Hydroxyindoleacetic Acid; Male; Meperidine; Methadone; Mice; Mice, Inbred ICR; Morphine; Naloxone; Pargyline; Probenecid; Rats; Serotonin | 1976 |
Characterization of (+/-)-methadone uptake by rat lung.
Topics: Animals; Extracellular Space; Glucose; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetates; Lung; Male; Methadone; Morphine; Naloxone; Oxygen; Rats; Sodium; Spectrometry, Fluorescence; Stereoisomerism; Time Factors | 1977 |
The effect of 6-hydroxydopamine on the antinociceptive action of analgesics in mice.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Female; Hydroxydopamines; Injections, Intraventricular; Levorphanol; Meperidine; Methadone; Mice; Morphine; Pentazocine; Reaction Time; Time Factors | 1977 |
Analgesic drugs in the management of pain.
Topics: Analgesics; Anti-Anxiety Agents; Aspirin; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Hypnotics and Sedatives; Ibuprofen; Indomethacin; Methadone; Morphine; Oxycodone; Pain; Pain, Intractable; Pentazocine; Pyrazoles | 1977 |
Electric shock titration: effects of morphine, metadone, pentazocine, naloriphine, naloxone, diazepam and amphetamine.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Dextroamphetamine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Haplorhini; Male; Methadone; Morphine; Naloxone; Narcotic Antagonists; Pentazocine; Saimiri | 1977 |
Thin-layer detection of pentazocine, tripelennamine, phencyclidine and propoxyphene alone or in combination with opiates in drug abuse urine screening programs.
Topics: Analgesics, Opioid; Chromatography, Thin Layer; Codeine; Dextropropoxyphene; Histamine H1 Antagonists; Humans; Methadone; Methods; Morphine; Pentazocine; Phencyclidine; Quinine; Substance-Related Disorders; Tripelennamine | 1978 |
Some considerations regarding the characterization and interpretation of neuropeptide-induced behavioral changes.
Topics: Animals; Behavior, Animal; Benzimidazoles; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Haloperidol; Humans; Injections, Intravenous; Injections, Intraventricular; Methadone; Mice; Morphine; Motor Activity; Naloxone; Peptides; Rats; Time Factors | 1978 |
Comparison of opiate- and opioid-peptide-induced immobility.
Topics: Amygdala; Animals; Benzimidazoles; Brain; Caudate Nucleus; Endorphins; Enkephalins; Globus Pallidus; Injections; Injections, Intraventricular; Injections, Subcutaneous; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1979 |
Immunologic effects of morphine administration in rabbits.
Topics: Animals; Antibody Formation; Binding, Competitive; Carbon Radioisotopes; Carrier Proteins; Chemical Fractionation; Codeine; Cyclophosphamide; Drug Implants; Electrophoresis, Polyacrylamide Gel; Female; gamma-Globulins; Hemagglutination Tests; Hemocyanins; Heroin; Immunodiffusion; Levorphanol; Methadone; Morphine; Naloxone; Rabbits; Skin Tests | 1975 |
Effect of morphine, hydromorphone, methadone, mescaline, trypan blue, vitamin A, sodium salicylate, and caffeine on the serum interferon level in response to viral infection.
Topics: Animals; Caffeine; Hydromorphone; Interferons; Male; Mescaline; Methadone; Mice; Morphine; Salicylates; Trypan Blue; Vesicular stomatitis Indiana virus; Virus Diseases; Vitamin A | 1975 |
[Strong opiate analgesics for cancer pain].
Topics: Humans; Methadone; Morphine; Narcotics; Neoplasms; Palliative Care | 1979 |
Behavioral supersensitivity to apomorphine following chronic narcotic treatment in the guinea pig.
Topics: Animals; Apomorphine; Behavior, Animal; Guinea Pigs; Haloperidol; Humans; Male; Methadone; Morphine; Stereotyped Behavior; Time Factors | 1978 |
Analgetic actions of intrathecal opiates in cat and primate.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Electroshock; Escape Reaction; Female; Haplorhini; Injections, Spinal; Methadone; Morphine; Nociceptors; Reaction Time; Skin | 1978 |
Drug metabolism by the fetal stump-tailed monkey (Macaca arctoides). Hepatic microsomal N-demethylation and glucuronidation as measured by radiometric assays.
Topics: Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Gestational Age; Glucuronidase; Haplorhini; Liver; Macaca; Meperidine; Methadone; Microsomes, Liver; Morphine; Organ Size; Oxidoreductases, N-Demethylating; Proteins | 1979 |
Decrease in serum prolactin by naloxone: evidence against antidopamine and antipsychotic effects.
Topics: Animals; Haloperidol; Haplorhini; Humans; Macaca; Male; Methadone; Morphine; Naloxone; Opioid-Related Disorders; Prolactin; Psychotic Disorders; Receptors, Dopamine | 1979 |
Effects of chronic treatment with morphine, methadone, and LAAM on the response to phencyclidine in rats.
Topics: Animals; Behavior, Animal; Drug Synergism; Humans; Male; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Phencyclidine; Rats | 1979 |
Dual action of morphine and related drugs on compulsive gnawing of rats.
Topics: Animals; Apomorphine; Behavior, Animal; Compulsive Behavior; Female; Fenclonine; Humans; Meperidine; Methadone; Morphine; Naloxone; Rats; Serotonin; Stereotyped Behavior; Thalamic Nuclei | 1976 |
Immunologic effects of morphine in rodents, rabbits, monkeys, and cats.
Topics: Animals; Antibody Formation; Antigen-Antibody Reactions; Blood; Cats; Codeine; Cross Reactions; Female; Guinea Pigs; Haplorhini; Haptens; Hemagglutination Tests; Immunodiffusion; Methadone; Morphine; Rabbits; Rats; Stereoisomerism | 1976 |
Role of 5-hydroxytryptamine in morphine-, pethidine-, and methadone-induced hypothermia in rats at low ambient and room temperature.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Cold Temperature; Depression, Chemical; Drug Interactions; Fenclonine; Male; Meperidine; Methadone; Morphine; Naloxone; Rats; Serotonin; Temperature; Time Factors | 1977 |
[Pharmacological analysis of the pendular movements appearing during calcium blocking of peristalsis in the isolated guinea pig ileum].
Topics: Animals; Atropine; Calcium; Gastrointestinal Motility; Guinea Pigs; Hexamethonium Compounds; Ileum; Methadone; Morphine; Muscle Contraction; Muscle, Smooth; Neostigmine; Peristalsis; Tetraethylammonium Compounds | 1977 |
Changes in brain cyclic AMP metabolism and acetylcholine and dopamine during narcotic dependence and withdrawal.
Topics: Acetylcholine; Acetylcholinesterase; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Dopamine; Humans; Hypothalamus; Male; Mesencephalon; Methadone; Morphine; Naloxone; Protein Kinases; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Thalamus | 1975 |
Effect of methadone on the male reproductive system.
Topics: Animals; Cyclic AMP; Male; Methadone; Mice; Morphine; Organ Size; Prostate; Seminal Vesicles; Testis | 1975 |
Human sleep during chronic morphine intoxication.
Topics: Adult; Alpha Rhythm; Arousal; Delta Rhythm; Drug Tolerance; Humans; Male; Methadone; Morphine; Morphine Dependence; Sleep; Sleep Stages; Sleep, REM; Substance Withdrawal Syndrome | 1975 |
Studies on tolerance development to single doses of morphine in mice.
Topics: 5,6-Dihydroxytryptamine; Animals; Brain; Cyclic AMP; Cycloheximide; Drug Tolerance; Female; Humans; Hydroxydopamines; Male; Methadone; Mice; Morphine; Pain; Reaction Time; Substance-Related Disorders; Time Factors; Tryptophan | 1976 |
The effects of narcotic analgesics and narcotic antagonists on ganglionic transmission in the rat.
Topics: Animals; Ganglia, Autonomic; Levorphanol; Male; Meperidine; Methadone; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Stereoisomerism; Synaptic Transmission | 1976 |
The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists.
Topics: Allosteric Regulation; Dextropropoxyphene; Fentanyl; Methadone; Models, Biological; Models, Molecular; Molecular Conformation; Morphine; Nalorphine; Naloxone; Narcotics; Pentazocine; Phenazocine; Protein Conformation; Receptors, Opioid; Structure-Activity Relationship | 1976 |
Opioid peptides and opiates differ in receptor selectivity.
Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1977 |
Opiate properties of SKF 525A.
Topics: Analgesia; Animals; Injections, Intraventricular; Male; Methadone; Morphine; Naloxone; Narcotics; Proadifen; Rats; Reaction Time; Receptors, Opioid | 1978 |
Electroencephalographic and behavioral tolerance and cross-tolerance to morphine and methadone in the rat.
Topics: Animals; Behavior, Animal; Drug Tolerance; Electroencephalography; Electromyography; Female; Methadone; Morphine; Rats; Sleep; Sleep, REM; Wakefulness | 1978 |
An x-ray microanalysis study of differences in concentration of elements in brain cells due to opiates, cell type, and subcellular location.
Topics: Animals; Brain; Brain Chemistry; Calcium; Chlorides; Electron Probe Microanalysis; Ependyma; Female; Magnesium; Methadone; Microscopy, Electron, Scanning; Morphine; Naloxone; Neurons; Phosphorus; Potassium; Preoptic Area; Rats; Receptors, Opioid; Sodium; Subcellular Fractions; Sulfur | 1978 |
Opioid self-administration and REM sleep EEG power spectra.
Topics: Animals; Electroencephalography; Female; Methadone; Methadyl Acetate; Morphine; Narcotics; Rats; Self Administration; Sleep, REM | 1979 |
Etonitazine-induced rigidity and its antagonism by centrally acting muscle relaxants.
Topics: Analgesics, Opioid; Animals; Benzimidazoles; Benzyl Compounds; Catalepsy; Codeine; Cordotomy; Diethylamines; Fenclonine; Humans; Male; Methadone; Morphine; Muscle Relaxants, Central; Muscle Rigidity; Narcotic Antagonists; Rats; Time Factors | 1975 |
A comparison of narcotic analgesics with neuroleptics on behavioral measures of dopaminergic activity.
Topics: Aggression; Amphetamine; Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Brain; Catalepsy; Dexetimide; Dextromoramide; Dogs; Dopamine; Drug Combinations; Haloperidol; Humans; Meperidine; Methadone; Mice; Morphine; Phenoperidine; Pimozide; Rats; Receptors, Drug; Stereotyped Behavior; Substance Withdrawal Syndrome; Tranquilizing Agents; Vomiting | 1975 |
Opiate-specific displacement of steroid hormones from microsomes.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Corticosterone; In Vitro Techniques; Male; Methadone; Microsomes, Liver; Morphine; Narcotic Antagonists; Progesterone; Rats; Receptors, Cell Surface; Receptors, Drug; Testosterone | 1975 |
A study of the effect of d-amphetamine on the toxicity, analgesic potency and swimming impairment caused by potent analgesics in mice.
Topics: Analgesics, Opioid; Animals; Depression, Chemical; Dextroamphetamine; Drug Synergism; Lethal Dose 50; Male; Methadone; Mice; Morphine; Pentazocine; Physical Exertion; Reaction Time; Swimming; Temperature | 1975 |
Opiates, prolactin, and the dopamine receptor.
Topics: Apomorphine; Bromocriptine; Chlorpromazine; Cyproheptadine; Heroin Dependence; Humans; Kinetics; Levodopa; Methadone; Morphine; Prolactin; Receptors, Dopamine | 1978 |
Secretion of drugs by the parotid glands of rats and human beings.
Topics: Acetylcholine; Adult; Amobarbital; Animals; Barbiturates; Chlorpromazine; Codeine; Glutethimide; Humans; Male; Meprobamate; Methadone; Morphine; Narcotics; Parotid Gland; Pentobarbital; Phenobarbital; Pilocarpine; Rats; Saliva; Secobarbital; Tranquilizing Agents | 1977 |
Dual action of methadone on 5-HT synthesis and metabolism.
Topics: 5-Hydroxytryptophan; Animals; Brain; Dihydroxyphenylalanine; Hydroxyindoleacetic Acid; Male; Methadone; Morphine; Naloxone; Probenecid; Rats; Serotonin; Tryptophan; Tyrosine | 1979 |
Specific conductivity of urine and sensitivity of enzyme immunoassay methods of analysis for drugs of abuse.
Topics: Amphetamine; Dextropropoxyphene; Diazepam; Electric Conductivity; Female; Humans; Immunoenzyme Techniques; Male; Methadone; Morphine; Sodium Chloride; Substance-Related Disorders; Urine | 1977 |
Assessment of the EMIT-(TM) technique as a screening test for opiates and methadone for a methadone maintenance clinic and its calibration by Bayesian statistics.
Topics: Chromatography, Thin Layer; Humans; Immunoenzyme Techniques; Mass Screening; Methadone; Morphine; Statistics as Topic | 1978 |
Hepatic extraction of long- and short-acting narcotics in the isolated perfused rabbit liver.
Topics: Animals; Biotransformation; Heroin; Liver; Liver Circulation; Meperidine; Methadone; Morphine; Narcotics; Rabbits; Time Factors | 1978 |
Effects of morphine, methadone, nalorphine and naloxone on responding under schedules of electric shock titration.
Topics: Analgesics; Animals; Avoidance Learning; Electroshock; Escape Reaction; Haplorhini; Male; Methadone; Morphine; Nalorphine; Naloxone; Punishment; Saimiri | 1977 |
Head-shake distributions during self-maintained dependence on morphine, methadone, and l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Animals; Behavior, Animal; Female; Humans; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Rats; Self Administration; Substance-Related Disorders | 1977 |
Effects of methadone and morphine maintenance on drug-seeking behavior in the dog.
Topics: Animals; Behavior, Animal; Dogs; Haplorhini; Humans; Methadone; Morphine; Papio; Rats; Self Administration; Substance Withdrawal Syndrome | 1977 |
Self-administration of heroin, acetylmethadol, morphine, and methadone in rhesus monkeys.
Topics: Animals; Behavior, Animal; Haplorhini; Heroin; Injections, Intravenous; Macaca mulatta; Methadone; Methadyl Acetate; Morphine; Narcotics; Respiration; Self Administration | 1978 |
Effects of medial raphe and raphe magnus lesions on the analgesic activity of morphine and methadone.
Topics: Analgesics; Animals; Brain Chemistry; Brain Stem; Male; Methadone; Morphine; Raphe Nuclei; Rats; Reaction Time; Serotonin; Time Factors | 1978 |
The effect of opiates on endogenous phosphorylation of proteins in the synaptic plasma membranes of rat striatum.
Topics: Animals; Corpus Striatum; Drug Tolerance; Illicit Drugs; Male; Methadone; Morphine; Naloxone; Narcotics; Nerve Tissue Proteins; Phenytoin; Phosphorylation; Protein Kinases; Rats; Synaptic Membranes | 1979 |
Analysis and differentiation of mechanism of tolerance to methadone in methadone-fed rats.
Topics: Analgesia; Animals; Drug Tolerance; Male; Methadone; Morphine; Phenobarbital; Rats; Tissue Distribution | 1979 |
Improved method for morphine extraction from biological samples.
Topics: Animals; Brain Chemistry; Chromatography, Thin Layer; Male; Methadone; Methods; Mice; Morphine; Naloxone | 1979 |
Effect of narcotics on monoamine oxidase activity of mouse brain.
Topics: Animals; Brain; Kinetics; Levorphanol; Male; Methadone; Mice; Monoamine Oxidase; Morphine; Narcotics | 1979 |
Discriminative stimulus properties of levo-alpha-acetylmethadol and its metabolites.
Topics: Animals; Discrimination, Psychological; Male; Methadone; Methadyl Acetate; Morphine; Rats; Time Factors | 1979 |
Anti-cholinesterase activity of 1-alpha-acetylmethadol: relationship to bradycardia.
Topics: Acetylcholinesterase; Animals; Bethanechol Compounds; Bradycardia; Butyrylcholinesterase; Cholinesterase Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Methadone; Methadyl Acetate; Morphine; Myocardium; Physostigmine | 1979 |
Naloxone-precipitated jumping in mice pretreated with acute injections of opioids.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Enkephalins; Heroin; Male; Methadone; Methadyl Acetate; Mice; Morphine; Naloxone; Narcotics; Pentazocine | 1979 |
Effect of methadone and morphine on serotonin uptake in rat periaqueductal gray slices.
Topics: Animals; Brain; Cerebral Aqueduct; In Vitro Techniques; Male; Methadone; Morphine; Naloxone; Rats; Serotonin | 1979 |
Drug-induced cues in studying mechanisms of drug action.
Topics: Animals; Cues; Drug Interactions; Electric Stimulation; Lysergic Acid Diethylamide; Male; Methadone; Methoxydimethyltryptamines; Morphine; Prejudice; Psychotropic Drugs; Raphe Nuclei; Rats; Receptors, Drug | 1979 |
Behavioral effects in offspring of male mice injected with opioids prior to mating.
Topics: Animals; Avoidance Learning; Behavior, Animal; Electroshock; Fathers; Male; Methadone; Mice; Morphine; Narcotics; Swimming; Time Factors | 1979 |
Analysis of reinforcement during intragastric self-administration of morphine and methadone in the rat.
Topics: Animals; Humans; Intubation; Male; Methadone; Morphine; Morphine Dependence; Rats; Reinforcement, Psychology; Self Administration | 1977 |
Tolerance and cross tolerance to toxic effects of morphine, methadone and 1-alpha-acetylmethadol (LAAM) in naive and morphine dependent rats.
Topics: Animals; Cross Reactions; Drug Tolerance; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Substance-Related Disorders | 1978 |
Antidiuretic effect of morphine in the rat: tolerance and physical dependence.
Topics: Animals; Diuresis; Drug Implants; Drug Tolerance; Humans; Injections, Intraperitoneal; Methadone; Morphine; Morphine Dependence; Naloxone; Rats; Sodium Chloride; Time Factors; Water | 1978 |
Tolerance, dependence and lethality in morphine-dependent mice after repeated oral administration of methadone.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Implants; Humans; Male; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome | 1978 |
Time course of dopaminergic hypersensitivity following chronic narcotic treatment.
Topics: Animals; Apomorphine; Dopamine; Guinea Pigs; Humans; Male; Methadone; Morphine; Narcotics; Stereotyped Behavior; Time Factors | 1979 |
Development of cellular tolerance to lethality and analgesia concurrent with physical dependence following repeated oral administration of LAAM.
Topics: Administration, Oral; Animals; Drug Tolerance; Humans; Injections, Intraventricular; Lethal Dose 50; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred ICR; Morphine; Naloxone; Nociceptors; Opioid-Related Disorders | 1979 |
Dose-time motility effects of morphine and methadone in naive or morphinized rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Methadone; Morphine; Morphine Dependence; Motor Activity; Rats; Time Factors | 1979 |
Comparing the effects of anileridine, alphaprodine and fentanyl on schedule-controlled responding by pigeons.
Topics: Alphaprodine; Animals; Behavior, Animal; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Fentanyl; Isonipecotic Acids; Male; Methadone; Morphine; Naloxone; Reinforcement Schedule | 1978 |
[Morphine intoxication and abstinence].
Topics: Dextropropoxyphene; Drug Tolerance; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome | 1977 |
Morphine and methadone-induced antinociception in rats permanently depleted of brain dopamine.
Topics: Analgesics; Animals; Brain; Dopamine; Female; Hydroxydopamines; Methadone; Morphine; Norepinephrine; Pregnancy; Rats | 1977 |
Pharmacologic activity of beta-endorphin in man.
Topics: Analgesics; Dose-Response Relationship, Drug; Endorphins; Heroin Dependence; Humans; Methadone; Morphine; Pain, Intractable; Substance Withdrawal Syndrome | 1977 |
Laboratory detection of morphine.
Topics: Amphetamines; Barbiturates; Humans; Indicators and Reagents; Methadone; Morphine | 1978 |
Midbrain raphe mediation of the narcotic blockade of ovulation.
Topics: Animals; Brain Stem; Female; Luteinizing Hormone; Mesencephalon; Methadone; Morphine; Naltrexone; Ovulation; Raphe Nuclei; Rats | 1978 |
Determination of drugs of abuse in body fluids by radioimmunoassay.
Topics: Amphetamines; Barbiturates; Body Fluids; Cocaine; Humans; Lysergic Acid Diethylamide; Methadone; Methaqualone; Morphine; Radioimmunoassay; Substance-Related Disorders | 1978 |
A comparative study on the behavioral response of offspring of female rats chronically treated with methadone and morphine.
Topics: Animals; Avoidance Learning; Behavior, Animal; Female; Male; Methadone; Morphine; Motor Activity; Pregnancy; Rats; Sex Factors; Time Factors | 1978 |
levo-Alpha-acetylmethadol and metabolites: some effects on schedule-controlled behavior in the rat.
Topics: Animals; Behavior, Animal; Male; Methadone; Methadyl Acetate; Morphine; Rats; Reinforcement Schedule; Time Factors | 1978 |
Shattering myths about hospice care.
Topics: Hospices; Humans; Methadone; Morphine; Pain; Terminal Care | 1978 |
Enhancement of morphine analgesia and brain levels by methamphetamine in mice.
Topics: Analgesia; Animals; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Male; Methadone; Methamphetamine; Mice; Morphine | 1978 |
Interaction toxicity between ethanol and narcotics in mice with reference to alpha-1-acetylmethadol (LAAM).
Topics: Animals; Brain; Dextrorphan; Drug Interactions; Ethanol; Lethal Dose 50; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Morphine; Narcotics | 1978 |
Cardiopulmonary effects of narcotic agonists and a partial agonist in horses.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Carotid Arteries; Heart Rate; Horses; Meperidine; Methadone; Morphine; Narcotics; Oxymorphone; Pentazocine; Respiration | 1978 |
Effects of preexposure to morphine and pentobarbital on disposition of methadone in isolated rat livers.
Topics: Animals; Bile; In Vitro Techniques; Liver; Male; Methadone; Morphine; Pentobarbital; Rats; Time Factors | 1978 |
Comparative validity of random-interval and fixed-interval urinalysis schedules.
Topics: Appointments and Schedules; Diagnostic Errors; Heroin Dependence; Humans; Methadone; Morphine; Quinine; Time Factors; Urine | 1978 |
Effects of d1-methadone and morphine on developing chick embryo.
Topics: Animals; Brain; Chick Embryo; Liver; Methadone; Morphine; Proteins | 1978 |
Effects of morphine and methadone on the nuclear uptake of estradiol by the brain.
Topics: Animals; Autoradiography; Brain; Cell Nucleus; Estradiol; Female; Methadone; Morphine; Rats | 1978 |
Drug use and employment patterns before and during treatment.
Topics: Amphetamines; Barbiturates; Codeine; Demography; Employment; Humans; Methadone; Morphine; Outcome and Process Assessment, Health Care; Substance-Related Disorders | 1978 |
Interference by NaCl with the EMIT method of analysis for drugs of abuse.
Topics: Chromatography, Thin Layer; False Negative Reactions; Humans; Immunoenzyme Techniques; Methadone; Morphine; Sodium Chloride; Substance-Related Disorders | 1976 |
Immunosuppression of rosette-forming cells.
Topics: Amphetamine; Animals; Body Weight; Caffeine; Erythrocytes; Humans; Immunity; Immunologic Techniques; Immunosuppression Therapy; Leukocytes; Male; Methadone; Mice; Morphine; Organ Size; Pentobarbital; Phenobarbital; Sheep; Spleen; Substance-Related Disorders | 1976 |
Comparison of immunogenicity of opiates bound to protein at different sites on the molecule: N-carboxy morphine-BSA.
Topics: Animals; Antibody Specificity; Binding Sites; Carrier Proteins; Codeine; Haptens; Heroin; Immune Sera; Immunologic Techniques; Levorphanol; Methadone; Morphine; Morphine Derivatives; Naloxone; Protein Binding; Rabbits; Rats; Serum Albumin, Bovine; Structure-Activity Relationship | 1976 |
Methadone maintenance.
Topics: Adult; Deception; Evaluation Studies as Topic; Female; Health Expenditures; Heroin Dependence; Humans; Male; Methadone; Morphine; Patient Compliance; Research; Socioeconomic Factors; United States; United States Food and Drug Administration | 1975 |
Characteristics of behavior controlled by scheduled injections of drugs.
Topics: Animals; Barbiturates; Behavior, Animal; Cocaine; Drug Administration Schedule; Environment; Food; Haplorhini; Humans; Macaca mulatta; Methadone; Methohexital; Morphine; Pharmaceutical Preparations; Reinforcement Schedule; Saimiri; Substance-Related Disorders; Time Factors | 1975 |
Drugs as reinforcers in monkey and man.
Topics: Animals; Codeine; Disease Models, Animal; Drug Therapy; Haplorhini; Heroin Dependence; Humans; Legislation, Drug; Methadone; Morphine; Pentazocine; Reinforcement Schedule; Reinforcement, Psychology; Substance-Related Disorders; United States | 1975 |
Evaluation of narcotic and narcotic antagonist interactions in primates.
Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration | 1976 |
Drug abuse proficiency testing.
Topics: Barbiturates; Cocaine; Dextroamphetamine; False Negative Reactions; Humans; Illicit Drugs; Laboratories; Methadone; Methamphetamine; Morphine; Pharmaceutical Preparations; Substance-Related Disorders; United States | 1977 |
Meperidine effects on schedule-controlled responding.
Topics: Animals; Columbidae; Conditioning, Operant; Cyclazocine; Drug Interactions; Drug Tolerance; Male; Meperidine; Methadone; Morphine; Naloxone; Reaction Time; Reinforcement Schedule | 1977 |
Cardiac effects of 1-alpha-acetylmethadol. I. Chronotropic effects in vitro.
Topics: Animals; Drug Interactions; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Methacholine Compounds; Methadone; Methadyl Acetate; Morphine; Naloxone; Norepinephrine | 1977 |
Binding of codeine, morphine, and methadone to human serum proteins.
Topics: Binding, Competitive; Blood Proteins; Codeine; Dialysis; Humans; Methadone; Morphine; Protein Binding; Serum Albumin | 1977 |
The discriminative stimulus properties of morphine in female rats chronically depleted of dopamine.
Topics: Animals; Brain Chemistry; Discrimination Learning; Discrimination, Psychological; Dopamine; Dose-Response Relationship, Drug; Female; Generalization, Stimulus; Haloperidol; Methadone; Morphine; Norepinephrine; Rats; Stimulation, Chemical; Time Factors | 1977 |
Toxic interactions of stimulants, narcotics and narcotic antagonists.
Topics: Animals; Cocaine; Cyclazocine; Dextroamphetamine; Drug Synergism; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats | 1977 |
The effects of morphine-like drugs and chlorpromazine on the synthesis of glycerolipids by homogenates of rat liver.
Topics: Animals; Chlorpromazine; Glycerides; Glycerophosphates; Liver; Methadone; Morphine; Morphine Derivatives; Rats | 1977 |
Calcium antagonist activity of methadone, l-acetylmethadol and l-pentazocine in the rat aortic strip.
Topics: Animals; Aorta, Thoracic; Calcium; Drug Interactions; In Vitro Techniques; Male; Methadone; Methadyl Acetate; Morphine; Muscle Contraction; Muscle, Smooth; Pentazocine; Rats; Stereoisomerism | 1977 |
Barbital-induced changes in sensitivity to the behavioral effects of narcotics.
Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Conditioning, Operant; Drug Interactions; Drug Tolerance; Male; Methadone; Morphine; Rats; Reinforcement Schedule | 1977 |
Quantum chemical studies of methadone.
Topics: Chemical Phenomena; Chemistry; Methadone; Models, Molecular; Molecular Conformation; Morphine; Quantum Theory | 1976 |
A dose-response comparison between methadone and morphine self-administration.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Humans; Male; Methadone; Morphine; Morphine Dependence; Rats | 1976 |
Effects of acute and chronic methadone treatment of the uptake of 3H-5-hydroxytryptamine in rat hypothalamus slices.
Topics: Animals; Dextrorphan; Female; Heroin; Humans; Hypothalamus; In Vitro Techniques; Levorphanol; Methadone; Morphine; Naloxone; Rats; Serotonin; Substance Withdrawal Syndrome; Time Factors | 1976 |
Alteration by methadone of catecholamine uptake and release in isolated rat adrenomedullary storage vesicles.
Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Biological Transport; Catecholamines; Cell-Free System; Kinetics; Male; Methadone; Morphine; Organoids; Rats; Reserpine; Temperature | 1976 |
Morphine: ability to block neuronal activity evoked by a nociceptive stimulus.
Topics: Action Potentials; Animals; Brain Stem; Chlorpromazine; Levorphanol; Male; Methadone; Morphine; Naloxone; Oxymorphone; Pain; Pentobarbital; Rats; Reticular Formation | 1976 |
Long-acting narcotic antagonist complexes.
Topics: Animals; Brain; Diprenorphine; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Reaction Time; Time Factors | 1976 |
Blockade of the specific lethal effects of narcotic analgesics in the mouse.
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Methadone; Mice; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Oxazepam; Trimethadione | 1976 |
[Letter: Use of naloxone (Narcan) in poisoning by morphine, methadone and dextro propoxyphene].
Topics: Dextropropoxyphene; Humans; Methadone; Morphine; Naloxone; Poisoning; Suicide, Attempted | 1976 |
Alterations in brain endogenous histamine levels in rats after chronic morphine treatment and morphine withdrawal.
Topics: Animals; Body Weight; Brain; Brain Stem; Cerebral Cortex; Histamine; Humans; Male; Methadone; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Time Factors | 1976 |
Fallibility of urine drug screens in monitoring methadone programs.
Topics: Amphetamine; Cocaine; Heroin Dependence; Humans; Laboratories; Licensure; Methadone; Morphine; Pharmaceutical Preparations; Secobarbital; Substance-Related Disorders; United States | 1976 |
Psychopathology and mood during heroin use: acute vs chronic effects.
Topics: Acute Disease; Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emotions; Euphoria; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Psychopathology | 1976 |
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1976 |
Microsomal enzyme induction by methadone and its implications on tolerance to methodone lethality.
Topics: Animals; Biotransformation; Drug Tolerance; Enzyme Induction; Lethal Dose 50; Liver; Methadone; Mice; Microsomes, Liver; Morphine; Organ Size; Oxidoreductases, N-Demethylating; Phenobarbital; Proteins | 1975 |
Increased neonatal mortality in offspring of male rats treated with methadone or morphine before mating.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Male; Methadone; Morphine; Mortality; Rats; Spermatozoa; Time Factors | 1975 |
Experience in the identification of abuse drugs in urines collected under Treatment Alternatives to Street Crime.
Topics: Amphetamine; Barbiturates; Charcoal; Chromatography, Gas; Chromatography, Thin Layer; Cocaine; Crime; Electronic Data Processing; Forensic Medicine; Humans; Mass Screening; Methadone; Methamphetamine; Morphine; Pharmaceutical Preparations; Spectrometry, Fluorescence; Substance-Related Disorders | 1975 |
Effects of narcotic antagonists on fluid intake in the rat.
Topics: Amphetamine; Animals; Cyclazocine; Feeding Behavior; Male; Methadone; Methyltyrosines; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Pentazocine; Rats | 1975 |
Accumulation of methadone by the choroid plexus in vitro.
Topics: Animals; Antimetabolites; Biological Transport; Calcium; Choroid Plexus; In Vitro Techniques; Magnesium; Male; Methadone; Morphine; Narcotic Antagonists; Phosphates; Rabbits; Time Factors; Verapamil | 1975 |
Simultaneous detection of a wide variety of commonly abused drugs in a urine screening program using thin-layer identification techniques.
Topics: 1-Propanol; Ammonia; Ammonium Chloride; Amphetamine; Barbiturates; Chloroform; Chromatography, Thin Layer; Codeine; Humans; Hypnotics and Sedatives; Indicators and Reagents; Ion Exchange Resins; Methadone; Methamphetamine; Methylphenidate; Morphine; Opium; Phenmetrazine; Substance-Related Disorders | 1975 |
Guidelines for the management of hospitalized narcotics addicts.
Topics: Analgesia; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Heroin; Hospitalization; Humans; Legislation, Drug; Male; Methadone; Morphine; Physician-Patient Relations; Pregnancy; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1975 |
Mechanism of development of tolerance to injected morphine by guinea pig ileum.
Topics: Acetylcholine; Animals; Drug Tolerance; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Methadone; Morphine; Muscle Contraction; Naloxone; Norepinephrine; Receptors, Drug; Serotonin; Time Factors | 1975 |
[Effect of analgesics on artificial bimolecular phospholipid membranes].
Topics: Analgesics; Dextromoramide; Dose-Response Relationship, Drug; Fentanyl; Membranes, Artificial; Methadone; Morphine; Phospholipids; Piperidines | 1975 |
Ligand-exchange chromatography of alkaloids.
Topics: Alkaloids; Atropine; Chromatography, Ion Exchange; Cinchona; Cinchona Alkaloids; Cocaine; Codeine; Copper; Hydrolysis; Ion Exchange Resins; Methadone; Methods; Morphine; Noscapine; Papaverine; Plants, Medicinal; Quinine; Strychnine | 1975 |
Effect of loperamide, haloperidol and methadone in rats trained to discriminate morphine from saline.
Topics: Animals; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Haloperidol; Male; Methadone; Morphine; Piperidines; Rats; Reinforcement Schedule; Sodium Chloride | 1975 |
Rapid screening of street drugs by high pressure liquid chromatography: the screening of cocaine, heroin, methadone and morphine by reverse phase HPLC.
Topics: Chromatography, High Pressure Liquid; Cocaine; Heroin; Methadone; Morphine | 1975 |
Blockade by narcotic drugs of naloxone-precipitated jumping in morphine-dependent mice.
Topics: Administration, Oral; Animals; Apomorphine; Behavior, Animal; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Injections, Intraperitoneal; Male; Meperidine; Methadone; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Narcotics; Pentazocine; Substance Withdrawal Syndrome | 1975 |
Investigations on drug produced and subjectively experienced discriminative stimuli. 2. Loperamide, an antidiarrheal devoid of narcotic cue producing actions.
Topics: Administration, Oral; Animals; Antidiarrheals; Codeine; Conditioning, Operant; Diphenoxylate; Discrimination Learning; Dose-Response Relationship, Drug; Fentanyl; Humans; Methadone; Morphine; Narcotics; Rats; Substance-Related Disorders; Time Factors | 1975 |
The offset of morphine tolerance in rats and mice.
Topics: Analgesics; Animals; Behavior, Animal; Drug Tolerance; Humans; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Rats; Time Factors | 1975 |
Renal toxicity of l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Animals; Hematuria; Kidney Diseases; Kidney Tubules; Methadone; Methadyl Acetate; Morphine; Naloxone; Nephrosis; Phenobarbital; Rats; Time Factors | 1975 |
Screening for drug abuse: use of NaCl to increase drug recovery from papers coated with ion-exchange resin.
Topics: Amphetamine; Chlorpromazine; Chromatography, Paper; Humans; Ion Exchange Resins; Methadone; Morphine; Morphine Derivatives; Paper; Pentobarbital; Sodium Chloride; Substance-Related Disorders | 1975 |
Binding of d-tubocurarine di (methyl-14C) ether iodide and other amines to cartilage, chondroitin sulfate and human plasma proteins.
Topics: Amines; Animals; Blood Proteins; Cartilage; Cattle; Chondroitin; Chondroitin Sulfates; Humans; In Vitro Techniques; Methadone; Morphine; Nasal Septum; Protein Binding; Tubocurarine | 1975 |
Schedule-induced oral narcotic self-administration: acute and chronic effects.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Male; Methadone; Morphine; Narcotics; Rats; Reinforcement Schedule; Time Factors | 1975 |
Duration of antinociceptive action of morphine, methadone and alpha-l-acetylmethadol subcutaneously in rats.
Topics: Analgesia; Animals; Injections, Subcutaneous; Male; Methadone; Methadyl Acetate; Morphine; Rats; Reaction Time; Time Factors; Vocalization, Animal | 1975 |
The toxicology of twelve cases of death involving methadone: examination of postmortem specimens.
Topics: Adolescent; Adult; Amobarbital; Autopsy; Diazepam; Ethanol; Female; Humans; Male; Methadone; Methaqualone; Morphine; Poisoning; Salicylates; Secobarbital | 1975 |
Clinical experience with naltrexone.
Topics: Administration, Oral; Adult; Female; Heroin Dependence; Hospitalization; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Naltrexone; Outpatient Clinics, Hospital; Patient Dropouts; Placebos; Time Factors | 1975 |
Long-acting narcotic antagonist complexes.
Topics: Aluminum; Animals; Brain; Buffers; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diprenorphine; Drug Stability; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Reaction Time; Zinc | 1975 |
Effects of narcotic agonists and antagonists on schedule-induced water and morphine ingestion.
Topics: Animals; Cyclazocine; Drinking Behavior; Humans; Methadone; Morphine; Morphine Dependence; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Reinforcement Schedule | 1975 |
Effects of morphine and methadone on serum testosterone and luteinizing hormone levels and on the secondary sex organs of the male rat.
Topics: Age Factors; Animals; Castration; Epididymis; Follicle Stimulating Hormone; Genitalia, Male; Hypophysectomy; Luteinizing Hormone; Male; Methadone; Morphine; Organ Size; Prostate; Rats; Seminal Vesicles; Testosterone | 1976 |
Heroin addiction. Sequential treatment employing pharmacologic supports.
Topics: Heroin Dependence; Humans; Methadone; Morphine; Naltrexone; Prognosis; Recurrence | 1976 |
Direct use of ion-exchange papers in hemagglutination-inhibition tests for drug abuse.
Topics: Aspirin; Chlorpromazine; Chromatography, Ion Exchange; Chromatography, Paper; Codeine; Hemagglutination Inhibition Tests; Humans; Methadone; Morphine; Nicotine; Phenobarbital; Substance-Related Disorders | 1976 |
Agonist and antagonist activity of kappa opioids in the squirrel monkey: I. Antinociception and urine output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Benzomorphans; Drug Interactions; Ethylketocyclazocine; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri; Urination | 1992 |
Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells.
Topics: Binding Sites; Calcium; Cell Death; Cell Division; Cell Membrane; Cyclic AMP; Cycloheximide; Dactinomycin; Growth Inhibitors; Humans; Methadone; Morphine; Naltrexone; Nicotine; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Stereoisomerism; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1992 |
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP) on ganglionic transmission.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Action Potentials; Animals; Electric Stimulation; Ganglia, Sympathetic; In Vitro Techniques; Male; Meperidine; Methadone; Morphine; Naloxone; Rats; Rats, Inbred Strains; Synaptic Transmission | 1992 |
Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Analgesics; Animals; Brain; Female; Gonadal Steroid Hormones; Male; Methadone; Mice; Morphine; Naltrexone; Narcotics; Orchiectomy; Ovariectomy; Reaction Time; Receptors, Opioid; Sex Characteristics; Up-Regulation | 1992 |
Sub-chronic exposure to opiates in the rat: effects on brain levels of substance P and calcitonin gene-related peptide during dependence and withdrawal.
Topics: Animals; Brain Chemistry; Calcitonin Gene-Related Peptide; Female; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Radioimmunoassay; Rats; Substance P; Substance Withdrawal Syndrome | 1992 |
[Significance of drug determination in pilocarpine sweat for detection of past drug abuse].
Topics: Adult; Cocaine; Female; Humans; Illicit Drugs; Male; Methadone; Morphine; Pilocarpine; Psychotropic Drugs; Substance Abuse Detection; Sweat; Time Factors | 1992 |
Immunological consequences of zidovudine treatment in control and morphine or methadone treated mice.
Topics: Animals; Cytotoxicity, Immunologic; Drug Interactions; Immune System; Killer Cells, Natural; Lymphocyte Activation; Male; Methadone; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Morphine; Neutrophils; Phagocytosis; T-Lymphocyte Subsets; Zidovudine | 1992 |
Morphine and methadone dependence in the rat: withdrawal and brain met-enkephalin levels.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Drinking; Enkephalin, Methionine; Female; Methadone; Morphine; Morphine Dependence; Naloxone; Radioimmunoassay; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1992 |
Morphine dispensing to long term problematic injectors.
Topics: Cause of Death; Drug Therapy, Combination; Follow-Up Studies; Humans; Methadone; Morphine; Netherlands; Opioid-Related Disorders; Substance Abuse, Intravenous | 1992 |
The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine.
Topics: Animals; Brain; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Methadone; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Seizures | 1991 |
Onset of tolerance to discriminative stimulus effects of morphine.
Topics: Animals; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Male; Methadone; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1991 |
Methadone dose and urine morphine.
Topics: Adult; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Product Surveillance, Postmarketing; Substance Abuse Detection; Substance Abuse Treatment Centers | 1991 |
Histamine release induced by opioid analgesics: a comparative study using porcine mast cells.
Topics: Analgesics, Opioid; Animals; Histamine Release; Hydromorphone; Kidney; Liver; Lung; Mast Cells; Meperidine; Methadone; Morphine; Myocardium; Oxycodone; Swine | 1991 |
[The analgesic action of d-phenylalanine in combination with morphine or methadone].
Topics: Action Potentials; Analgesics; Animals; Drug Interactions; Male; Methadone; Mice; Morphine; Pain Measurement; Phenylalanine; Rats; Rats, Inbred Strains | 1991 |
Differential cross-tolerance to mu and kappa opioid agonists in morphine-tolerant rats responding under a schedule of food presentation.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Chlorpromazine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Ethylketocyclazocine; Fentanyl; Food; Male; Methadone; Morphine; Naloxone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 1991 |
Acute and chronic morphine administration: effects of mixed-action opioids in rats and squirrel monkeys responding under a schedule of food presentation.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Tolerance; Male; Methadone; Morphine; Nalorphine; Naloxone; Rats; Receptors, Opioid; Saimiri; Species Specificity | 1991 |
Treatment of severe cancer pain by continuous infusion of subcutaneous opioids.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Pain Measurement | 1991 |
The effect of prenatal methadone exposure of development and nociception during the early postnatal period of the rat.
Topics: Animals; Female; Methadone; Morphine; Nociceptors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reaction Time; Self Administration | 1990 |
Differential cross-tolerance to opioids in squirrel monkeys responding under a shock titration schedule.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Cyclazocine; Drug Tolerance; Electroshock; Ethylketocyclazocine; Male; Methadone; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri | 1990 |
Codeine O-demethylation: rat strain differences and the effects of inhibitors.
Topics: Animals; Codeine; Drug Interactions; Female; Kinetics; Methadone; Microsomes, Liver; Morphine; Oxidoreductases, O-Demethylating; Phenotype; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1991 |
Performance of techniques used to detect drugs of abuse in urine: study based on external quality assessment.
Topics: Amphetamine; Chromatography, Gas; Chromatography, Thin Layer; Cocaine; False Positive Reactions; Humans; Immunoassay; Methadone; Morphine; Quality Control | 1991 |
Tolerance to morphine-like stimulus effects of mu opioid agonists.
Topics: Animals; Buprenorphine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Male; Methadone; Morphine; Rats; Rats, Inbred Strains | 1991 |
Intrathecal methadone: a dose-response study and comparison with intrathecal morphine 0.5 mg.
Topics: Aged; Analgesia; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Methadone; Middle Aged; Morphine; Pain Measurement; Time Factors | 1990 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Discriminative stimulus properties of U50,488 and morphine: effects of training dose on stimulus substitution patterns produced by mu and kappa opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Morphine; Naloxone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1990 |
The Amsterdam morphine-dispensing experiment.
Topics: Adult; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Methadone; Morphine; Netherlands; Substance Abuse Treatment Centers; Substance-Related Disorders | 1990 |
Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Fentanyl; Levorphanol; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Time Factors | 1990 |
Central neurogenic hyperventilation: pharmacologic intervention with morphine sulfate and correlative analysis of respiratory, sleep, and ocular motor dysfunction.
Topics: Adult; Astrocytoma; Brain Neoplasms; Drug Therapy, Combination; Eye Movements; Female; Humans; Hyperventilation; Methadone; Morphine; Pons; Respiration; Saccades; Sleep | 1990 |
Does intravenous methadone provide longer lasting analgesia than intravenous morphine?
Topics: Analgesia; Humans; Injections, Intravenous; Methadone; Morphine; Time Factors | 1990 |
Blockade of high K+ contractures and Ca(+)+-dependent slow action potentials in frog skeletal muscle by opioid drugs.
Topics: Action Potentials; Animals; Calcium; Dextrorphan; Endorphins; In Vitro Techniques; Levorphanol; Methadone; Morphine; Muscle Contraction; Muscles; Narcotics; Potassium; Rana pipiens | 1990 |
Epidural and intrathecal opiates: cerebrospinal fluid and plasma profiles in patients with chronic cancer pain.
Topics: Adult; Aged; beta-Endorphin; Drug Evaluation; Endorphins; Epidural Space; Female; Half-Life; Humans; Injections, Spinal; Kinetics; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable; Palliative Care | 1985 |
I.v. infusion of opioids for cancer pain: clinical review and guidelines for use.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Administration Schedule; Drug Evaluation; Humans; Hydromorphone; Infant; Infusions, Parenteral; Levorphanol; Methadone; Middle Aged; Morphine; Narcotics; Neoplasms; Oxymorphone; Pain, Intractable; Palliative Care; Retrospective Studies | 1986 |
Exceptionally high narcotic analgesic requirements in a terminally ill cancer patient.
Topics: Adult; Analgesics, Opioid; Combined Modality Therapy; Drug Tolerance; Female; Humans; Hydromorphone; Methadone; Morphine; Neoplasms; Pain | 1986 |
Unusual opioid withdrawal syndrome. A case-report.
Topics: Aged; Colonic Neoplasms; Coma; Humans; Male; Methadone; Morphine; Neoplasm Recurrence, Local; Opium; Palliative Care; Receptors, Opioid; Substance Withdrawal Syndrome | 1987 |
Sublingual absorption of selected opioid analgesics.
Topics: Administration, Sublingual; Adult; Analgesics, Opioid; Analysis of Variance; Biological Availability; Buprenorphine; Fentanyl; Heroin; Humans; Hydromorphone; Levorphanol; Methadone; Morphine; Mouth; Naloxone; Oxycodone; Time Factors | 1988 |
Suppression of human peripheral blood mononuclear cell function by methadone and morphine.
Topics: Adult; Cells, Cultured; HIV Seropositivity; Humans; In Vitro Techniques; Interferon-gamma; Leukocytes, Mononuclear; Methadone; Middle Aged; Morphine; Naloxone; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Intrathecal opioids, potency and lipophilicity.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Endorphins; Injections, Spinal; Membrane Lipids; Meperidine; Methadone; Morphine; Morphine Derivatives; Nociceptors; Rats; Receptors, Opioid; Receptors, Opioid, mu; Solubility; Spinal Cord | 1989 |
Differences in efficacies between morphine and methadone demonstrated in the guinea pig ileum: a possible explanation for previous observations on incomplete opioid cross-tolerance.
Topics: Alkylation; Animals; Drug Tolerance; Electric Stimulation; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Methadone; Morphine; Muscle, Smooth; Receptors, Opioid | 1989 |
A new analysis of whole-body calorimetry data.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Temperature Regulation; Brain; Calorimetry; Methadone; Morphine; Oxygen Consumption; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Effects of mixed-action opioids on food-maintained behavior of morphine-pretreated and morphine-tolerant rats.
Topics: Animals; Appetitive Behavior; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Methadone; Morphine; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 1989 |
New differences between the Wistar rat and Octodon degus, a putative laboratory animal resistant to morphine.
Topics: Adrenal Glands; Animals; Catecholamines; Drug Resistance; Electroencephalography; Ethanol; Female; Hemodynamics; In Vitro Techniques; Intestine, Small; Male; Methadone; Morphine; Naloxone; Rats; Rats, Inbred Strains; Respiration; Rodentia | 1989 |
Fatal intoxications in the age group 15-34 years in Denmark in 1984 and 1985. A forensic study with special reference to drug addicts.
Topics: Adolescent; Adult; Analgesics, Opioid; Barbiturates; Cause of Death; Cross-Sectional Studies; Denmark; Dextropropoxyphene; Drug Overdose; Heroin; Humans; Incidence; Meperidine; Methadone; Morphine; Substance-Related Disorders | 1989 |
Antiaversive properties of opioids in the conditioned taste aversion test in the rat.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fentanyl; Male; Methadone; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste | 1987 |
Evaluation of the effects of opioid agonists and antagonists under a delayed matching-to-sample procedure in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Columbidae; Cyclazocine; Discrimination Learning; Endorphins; Ethylketocyclazocine; Female; Methadone; Morphine; Naloxone; Phencyclidine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1987 |
Orally administered kappa as well as mu opiate agonists delay gastrointestinal transit time in the guinea pig.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animals; Etorphine; Gastrointestinal Motility; Guinea Pigs; Male; Methadone; Morphine; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Topics: Animals; Benzomorphans; Caudate Nucleus; Dopamine; Male; Methadone; Morphine; Motor Activity; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Septal Nuclei | 1988 |
Analeptic effect of opiate receptor agonists in rabbits.
Topics: Animals; Arousal; Brain; Central Nervous System Stimulants; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Enkephalin, Methionine; Ethylketocyclazocine; Etorphine; Male; Meperidine; Methadone; Morphine; Naltrexone; Narcotics; Phenazocine; Rabbits; Receptors, Opioid; Reflex | 1985 |
5-HT-uptake inhibition potentiates antinociception induced by morphine, pethidine, methadone and ketobemidone in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Brain; Citalopram; Drug Synergism; Male; Meperidine; Methadone; Morphine; Propylamines; Rats; Rats, Inbred Strains; Reaction Time; Serotonin; Serotonin Antagonists; Synaptosomes | 1985 |
Differential cross-tolerance among morphine, methadone, and ethylketocyclazocine--EEG and behavior.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Cyclazocine; Drug Tolerance; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Morphine; Rats; Rats, Inbred Strains | 1986 |
Hallucination during sustained-release morphine and methadone administration.
Topics: Delayed-Action Preparations; Hallucinations; Humans; Male; Methadone; Middle Aged; Morphine | 1987 |
Prescribing for drug addicts.
Topics: Drug Prescriptions; Heroin; Humans; Methadone; Morphine; Substance-Related Disorders | 1987 |
Enhancement of opioid cataleptic response by cortical frontal deafferentation or intrastriatal injection of NMDA-receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Catalepsy; Cerebral Cortex; Cerebral Ventricles; Corpus Striatum; Female; Kinetics; Methadone; Morphine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Valine | 1988 |
Narcotic usage in renal failure.
Topics: Analgesics, Opioid; Codeine; Humans; Kidney Failure, Chronic; Methadone; Morphine | 1988 |
Plasma arginine vasopressin response to intravenous methadone and naloxone in conscious dogs.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Dogs; Female; Heart Rate; Injections, Intravenous; Male; Methadone; Morphine; Naloxone | 1989 |
High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications.
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Cats; Drug Tolerance; Fentanyl; Hyperesthesia; Methadone; Morphine; Morphine Derivatives; Naltrexone; Rats; Receptors, Drug; Stimulation, Chemical; Strychnine; Sufentanil; Sulfates; Touch | 1986 |
Crisis in drug testing. Results of CDC blind study.
Topics: Amphetamines; Barbiturates; Centers for Disease Control and Prevention, U.S.; Cocaine; Codeine; Diagnostic Errors; Humans; Illicit Drugs; Laboratories; Methadone; Morphine; Pharmaceutical Preparations; Quality Control; Research Design; United States | 1985 |
Opioid activity of lefetamine.
Topics: Anesthetics, Local; Animals; Binding, Competitive; Brain; Cyclazocine; Enkephalin, Methionine; Ethylketocyclazocine; Lethal Dose 50; Male; Methadone; Mice; Morphine; Naloxone; Phenethylamines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid | 1985 |
Maternal-fetal transfer of abused substances: pharmacokinetic and pharmacodynamic data.
Topics: Amphetamine; Animals; Cocaine; Dronabinol; Female; Fetus; Humans; Kinetics; Lysergic Acid Diethylamide; Maternal-Fetal Exchange; Meperidine; Methadone; Morphine; Nicotine; Phencyclidine; Pregnancy; Substance-Related Disorders | 1985 |
Opioid-hallucinogen interactions.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hallucinogens; Liver; Lysergic Acid Diethylamide; Male; Methadone; Morphine; N,N-Dimethyltryptamine; Naloxone; Narcotics; Rats; Receptors, Opioid; Receptors, Opioid, mu; Stereoisomerism | 1986 |
Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Biological Assay; Buprenorphine; Butorphanol; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Etorphine; Fentanyl; Methadone; Mice; Morphine; Muscle Contraction; Nalbuphine; Nalorphine; Naltrexone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Methadone vs morphine: comparison of their effect on phagocytic functions.
Topics: Animals; Candidiasis; Macrophages; Male; Methadone; Mice; Mononuclear Phagocyte System; Morphine; Neutrophils; Phagocytosis; Propionibacterium acnes; Pulmonary Alveoli; Superoxides | 1987 |
Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Indicators and Reagents; Methadone; Mice; Morphine; N-Methylaspartate; Naloxone; Narcotics; Neurons; Stereoisomerism | 1988 |
Endocrine consequences of perinatal methadone exposure.
Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Disease Models, Animal; Hypothalamo-Hypophyseal System; Methadone; Morphine; Prolactin; Rats; Substance-Related Disorders | 1987 |
Combined use of detomidine with opiates in the horse.
Topics: Animals; Behavior, Animal; Blood Pressure; Butorphanol; Heart Rate; Horses; Hypnotics and Sedatives; Imidazoles; Meperidine; Methadone; Morphine; Narcotics; Pulmonary Gas Exchange | 1988 |
Mechanisms of the contractile responses to morphine of the mouse colon in vitro.
Topics: Animals; Colon; In Vitro Techniques; Methadone; Mice; Morphine; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Neostigmine; Serotonin Antagonists | 1988 |
[3-step pharmacologic treatment of pain in cancer. Preliminary experience in Chile].
Topics: Acetaminophen; Adult; Analgesics; Chile; Codeine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Pain Measurement | 1988 |
Comparison of the discriminative stimulus properties of U50,488 and morphine in pigeons.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Columbidae; Cyclazocine; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Female; Fentanyl; Methadone; Morphine; Naloxone; Phenazocine; Phencyclidine; Pyrrolidines; Time Factors | 1987 |
Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment.
Topics: Alprazolam; Analgesia; Animals; Ataxia; Cocaine; Drug Implants; Kinetics; Male; Methadone; Mice; Morphine; Naloxone; Narcotics | 1988 |
Effects of opiates on the growth of neuron-enriched cultures from chick embryonic brain.
Topics: Animals; Brain; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; Dendrites; Methadone; Morphine; Narcotics | 1986 |
Mechanism for the opioid-induced twitch potentiations of frog's skeletal muscle.
Topics: Animals; Calcium; Dextrorphan; Etorphine; In Vitro Techniques; Meperidine; Methadone; Morphine; Muscle Contraction; Muscles; Narcotics; Rana pipiens; Stimulation, Chemical | 1986 |
Evaluation of the effects of opioid agonists and antagonists under a fixed-consecutive-number schedule in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Male; Methadone; Morphine; Naloxone; Narcotics; Phenazocine; Pyrrolidines; Rats; Reinforcement Schedule | 1987 |
Changing the route of administration in children.
Topics: Administration, Oral; Child; Female; Humans; Injections, Intravenous; Methadone; Morphine; Pain, Intractable; Patient Discharge | 1986 |
The availability of narcotics and attitudes towards their use.
Topics: Adrenal Gland Neoplasms; Child, Preschool; Female; Humans; Methadone; Morphine; Neuroblastoma; Pain | 1986 |
Aspects of abstinence after morphine ingestion.
Topics: Animals; Body Weight; Diarrhea; Dose-Response Relationship, Drug; Drinking; Male; Methadone; Methods; Morphine; Morphine Dependence; Motor Activity; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Time Factors | 1987 |
Morphine discrimination in the pigeon using a color tracking procedure.
Topics: Animals; Cocaine; Color; Columbidae; Cues; Cyclazocine; Dextroamphetamine; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Response; Male; Meperidine; Methadone; Morphine; Narcotics; Pentobarbital; Phencyclidine; Psychomotor Performance | 1986 |
[Epidural analgesia with morphine and methadone].
Topics: Anesthesia, Epidural; Animals; Humans; Methadone; Morphine | 1986 |
The action of intrathecal morphine and methadone on the lower urinary tract in the dog.
Topics: Animals; Compliance; Dogs; Female; Injections, Spinal; Methadone; Morphine; Muscle, Smooth; Pressure; Time Factors; Urethra; Urinary Bladder; Urodynamics | 1986 |
A chronic sheep preparation for the study of drug pharmacokinetics in spinal and ventricular CSF.
Topics: Animals; Cerebral Ventricles; Female; Infusions, Intravenous; Kinetics; Methadone; Models, Biological; Morphine; Pharmaceutical Preparations; Sheep; Spinal Cord; Subarachnoid Space; Sucrose | 1986 |
CSF distribution of morphine, methadone and sucrose after intrathecal injection.
Topics: Animals; Cisterna Magna; Dose-Response Relationship, Drug; Female; Injections, Spinal; Kinetics; Methadone; Morphine; Sheep; Sucrose | 1985 |
Managing intractable pain with methadone (nursing grand rounds).
Topics: Adenocarcinoma; Female; Humans; Methadone; Middle Aged; Morphine; Pain, Intractable; Patient Care Planning | 1985 |
Displacement of the surface membrane bound calcium of the skeletal muscle fibers of the frog: effects of lanthanum and opioids.
Topics: Animals; Binding Sites; Calcium; Cell Membrane; In Vitro Techniques; Lanthanum; Meperidine; Methadone; Morphine; Muscles; Narcotics; Rana pipiens | 1985 |
The graded and quantal nature of opioid analgesia in the rat tailflick assay.
Topics: Animals; Dose-Response Relationship, Drug; Kinetics; Male; Methadone; Morphine; Pain; Rats; Reaction Time | 1985 |
Opiate-induced rhabdomyolysis.
Topics: Acute Kidney Injury; Adult; Aspartate Aminotransferases; Codeine; Creatine Kinase; Creatinine; Cyclizine; Drug Combinations; Female; Humans; Hypocalcemia; Male; Methadone; Middle Aged; Morphine; Myoglobin; Narcotics; Phosphates; Rhabdomyolysis; Suicide, Attempted | 1985 |
Effects of acute and chronic morphine treatment on methadone analgesia and metabolism.
Topics: Analgesics; Animals; Brain; Drug Implants; Drug Synergism; Liver; Male; Methadone; Morphine; Rats; Rats, Inbred Strains; Tissue Distribution | 1985 |
Opiate self-administration in adult offspring of methadone-treated female rats.
Topics: Animals; Body Weight; Drinking; Female; Methadone; Morphine; Narcotics; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Self Administration; Time Factors | 1985 |
Cross-sensitization to the excitatory effect of morphine in post-dependent rats.
Topics: Animals; Male; Meperidine; Methadone; Morphine; Morphine Dependence; Motor Activity; Pentazocine; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Urinary function during epidural analgesia with methadone and morphine in post-cesarean section patients.
Topics: Adult; Anesthesia, Epidural; Cesarean Section; Female; Humans; Methadone; Morphine; Pain, Postoperative; Postoperative Complications; Pregnancy; Urination; Urination Disorders | 1985 |
Pharmacokinetics of morphine and its surrogates. VII: High-performance liquid chromatographic analyses and pharmacokinetics of methadone and its derived metabolites in dogs.
Topics: Animals; Bile; Biotransformation; Body Fluids; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dogs; Hydrogen-Ion Concentration; Hydrolysis; Injections, Intravenous; Kinetics; Male; Methadone; Morphine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1985 |
-Globulin binding of morphine in heroin addicts.
Topics: Ammonium Sulfate; Animals; Antibody Formation; Centrifugation, Density Gradient; Chemical Precipitation; Chemistry Techniques, Analytical; Dialysis; Electrophoresis, Starch Gel; gamma-Globulins; Heroin; Humans; Immunodiffusion; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Methadone; Morphine; Protein Binding; Rabbits; Substance-Related Disorders; Sucrose; Tritium | 1972 |
Sensitivity of thin-layer chromatography for detection of 16 opioids, cocaine and quinine.
Topics: Alphaprodine; Chromatography, Thin Layer; Cocaine; Codeine; Cyclazocine; Dextropropoxyphene; Humans; Hydromorphone; Levallorphan; Levorphanol; Meperidine; Methadone; Methods; Morphinans; Morphine; Nalorphine; Naloxone; Oxymorphone; Pentazocine; Quinine | 1972 |
Rapid methods of screening micro-quantities of abused drugs from urine samples for microcrystal tests.
Topics: Acids; Alkalies; Alkaloids; Chromatography, Thin Layer; Codeine; Crystallization; Crystallography; Heroin Dependence; Humans; Hydromorphone; Indicators and Reagents; Meperidine; Methadone; Methods; Morphine; Nicotine; Quinine; Substance-Related Disorders | 1973 |
Stereospecific uptake of narcotic analgesics by a subcellular fraction of the guinea-pig ileum. A preliminary communication.
Topics: Analgesics; Animals; Codeine; Dextromoramide; Female; Guinea Pigs; Hydromorphone; Ileum; In Vitro Techniques; Intestinal Absorption; Levorphanol; Male; Methadone; Morphine; Muscle, Smooth; Nalorphine; Naloxone; Narcotics; Subcellular Fractions; Tritium | 1973 |
Evaluation of immunoassay methods for detection, in urine, of drugs subject to abuse.
Topics: Amphetamine; Apomorphine; Barbiturates; Chromatography, Thin Layer; Cocaine; Codeine; Cross Reactions; Cyclazocine; Dextromethorphan; Dextropropoxyphene; Evaluation Studies as Topic; Hemagglutination Inhibition Tests; Heroin; Humans; Hydromorphone; Levorphanol; Methadone; Methods; Microchemistry; Morphine; Nalorphine; Radioimmunoassay; Spectrometry, Fluorescence; Substance-Related Disorders; Time Factors; Tritium | 1974 |
Contribution of 'receptor' affinity to analgesic potency.
Topics: 1-Propanol; Analgesics; Animals; Binding, Competitive; Brain; Cyclopropanes; Fentanyl; Guinea Pigs; Hydromorphone; In Vitro Techniques; Injections, Intravenous; Levorphanol; Meperidine; Methadone; Morphinans; Morphine; Pentanols; Receptors, Drug | 1974 |
[Analgesia in myocardial infarct].
Topics: Analgesics; Diazepam; Heart; Hemodynamics; Heroin; Humans; Hydromorphone; Meperidine; Methadone; Morphine; Myocardial Infarction; Nitrogen Oxides; Pain; Pentazocine; Respiration | 1974 |
Inspiratory versus expiratory efforts in pigeons: a search for selective drug influence.
Topics: Anesthesia; Animals; Atropine; Barbiturates; Benzoates; Chloralose; Chlorpromazine; Codeine; Columbidae; Ethanol; Methadone; Methylphenidate; Morphine; Nalorphine; Nikethamide; Noscapine; Pregnanediones; Respiration; Trachea; Urethane | 1973 |
Antagonism of acute lethality of narcotic analgesics in aggregated and isolated mice by the central cholinomimetic action of pilocarpine.
Topics: Analgesics, Opioid; Animals; Atropine; Atropine Derivatives; Crowding; Depression, Chemical; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Levorphanol; Male; Meperidine; Methadone; Mice; Morphine; Motor Activity; Parasympathomimetics; Pentazocine; Pilocarpine; Social Isolation; Stimulation, Chemical; Time Factors | 1974 |
[Ionization constants of several narcotic analgesics and their pain relieving activity].
Topics: Analgesics, Opioid; Benzilates; Chemical Phenomena; Chemistry, Physical; Codeine; Dextromoramide; Dimethylamines; Kinetics; Levorphanol; Meperidine; Methadone; Morphine; Muscle Relaxants, Central; Phenylacetates; Structure-Activity Relationship | 1973 |
Changing patterns of drug abuse in New York City.
Topics: Adolescent; Adult; Amitriptyline; Amphetamines; Antipsychotic Agents; Barbiturates; Codeine; Dextropropoxyphene; Female; Glutethimide; Heroin Dependence; Humans; Male; Methadone; Morphine; New York City; Phenothiazines; Phenytoin; Quinine; Substance-Related Disorders | 1974 |
Narcotic blockade.
Topics: Drug Tolerance; Follow-Up Studies; Heroin; Humans; Hydromorphone; Injections, Intravenous; Methadone; Morphine; Rehabilitation; Substance Withdrawal Syndrome; Substance-Related Disorders | 1966 |
Narcotic blockade--a medical technique for stopping heroin use by addicts.
Topics: Euphoria; Heroin; Humans; Hydromorphone; Methadone; Morphine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1966 |
Urine screening techniques employed in the detection of users of narcotics and their correlation with the nalorphine test.
Topics: Amphetamine; California; Cocaine; Codeine; Humans; Hydromorphone; Meperidine; Methadone; Morphine; Nalorphine; Pupil; Substance-Related Disorders | 1966 |
Tolerance to the lenticular effects of opiates.
Topics: Animals; Dactinomycin; Drug Tolerance; Epinephrine; Female; Lens, Crystalline; Levorphanol; Methadone; Mice; Morphine; Puromycin; Reserpine | 1967 |
Heroin and cocaine addiction.
Topics: Adolescent; Adult; Amphetamine; Barbiturates; Cannabis; Cocaine; Dextroamphetamine; Ethanol; Female; Follow-Up Studies; Heroin; Hospitalization; Hospitals, Psychiatric; Humans; Injections, Intravenous; Male; Methadone; Morphine; Substance Withdrawal Syndrome; Substance-Related Disorders; United Kingdom; United States | 1965 |
Interactions of narcotics and their antagonists with human serum esterase. II: nature of the antagonism.
Topics: Drug Antagonism; Enzymes; Esterases; Humans; Hydromorphone; Levorphanol; Methadone; Models, Theoretical; Morphine; Nalorphine; Narcotic Antagonists; Procaine; Spectrophotometry | 1966 |
Interactions of narcotics and their antagonists with human serum esterase. I: sites of action and nature of the inhibitory effect.
Topics: Drug Antagonism; Drug Synergism; Enzymes; Esterases; Humans; Hydromorphone; Levorphanol; Methadone; Morphine; Nalorphine; Narcotic Antagonists; Procaine; Spectrophotometry | 1966 |
A method of identifying narcotic analgesics in human urine after therapeutic doses.
Topics: Alkaloids; Analgesics; Carbon Isotopes; Chromatography, Thin Layer; Codeine; Humans; Hydromorphone; Ion Exchange; Levorphanol; Meperidine; Methadone; Methods; Morphine; Narcotics; Pentazocine | 1970 |
[Permeation of active morphine-like substances at their sites of antinociceptive action in the brain as a function of their lipid-solubility following intravenous and intraventricular application].
Topics: Animals; Brain; Carbon Isotopes; Chromatography, Thin Layer; Codeine; Dental Pulp Test; Fentanyl; Hydromorphone; Ketones; Kinetics; Levorphanol; Lipids; Methadone; Morphinans; Morphine; Piperidines; Rabbits; Solubility; Tritium | 1970 |
Application of enzyme kinetics to a problem in pharmacology: receptor affinities and efficacies in the action of morphine and related drugs on human serum esterase.
Topics: Esterases; Hydromorphone; Kinetics; Levorphanol; Mathematics; Metabolism; Methadone; Morphine; Nalorphine | 1970 |
Effects of opioid narcotic drugs on energy reserves of skeletal muscle. I. Glycogen.
Topics: Animals; Calcium; Carbon Radioisotopes; Diaphragm; Drug Tolerance; Energy Metabolism; Epinephrine; Glucose; Glycogen; Glycogen Synthase; In Vitro Techniques; Male; Meperidine; Methadone; Morphinans; Morphine; Muscles; Narcotics; Phosphoglucomutase; Phosphorylases; Propranolol; Rats; Time Factors | 1974 |
[Behavioral changes and relationships and electrocorticograms induced in the rabbit by prolonged administration of morphine analgesics].
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Methadone; Morphine; Rabbits | 1966 |
Suppression of craving and other signs of dependence in morphine-addicted monkeys by administration of alpha-methyl-para-tyrosine.
Topics: Animals; Female; Fenclonine; Haloperidol; Haplorhini; Humans; Hypothalamus; Injections, Intravenous; Macaca; Methadone; Methyltyrosines; Morphine; Nalorphine; Septal Nuclei; Substance Withdrawal Syndrome; Substance-Related Disorders; Thioridazine; Trifluoperazine | 1972 |
5-hydroxytryptamine in platelets and brain of rabbits treated chronically with imipramine, morphine or methadone.
Topics: Animals; Blood Platelets; Brain Chemistry; Hydroxyindoleacetic Acid; Imipramine; Male; Methadone; Morphine; Rabbits; Serotonin; Time Factors | 1973 |
Proceedings: A simple model for the assessment of analgetic tolerance in the rat.
Topics: Analgesics; Animals; Drug Tolerance; Methadone; Models, Biological; Morphine; Pressure; Rats; Time Factors | 1974 |
Compulsive gnawing in rats after implantation of drugs into the ventral thalamus. A contribution to the mechanism of morphine action.
Topics: Amphetamine; Animals; Apomorphine; Brain; Chlorpromazine; Compulsive Behavior; Corpus Striatum; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Fenclonine; Haloperidol; Humans; Meperidine; Methadone; Methyldopa; Methyltyrosines; Morphine; Nalorphine; Phenoxybenzamine; Phentolamine; Pimozide; Rats; Thalamus | 1974 |
Hyposensitivity to drugs induced by morphine and some related substances in the cat.
Topics: Angiotensin II; Animals; Blood Pressure; Cats; Epinephrine; Female; Meperidine; Methadone; Morphine; Muscle, Smooth; Nalorphine; Nictitating Membrane; Norepinephrine; Tachyphylaxis; Uterus; Venous Pressure | 1970 |
Liquid-solid extraction of lyophilized biological materials for forensic analysis. II. Application to bile samples for the detection of drugs.
Topics: Bile; Chromatography, Thin Layer; Fluorometry; Forensic Medicine; Freeze Drying; Gels; Humans; Hydrogen-Ion Concentration; Methadone; Methods; Morphine; Silicon Dioxide | 1972 |
Spin immunoassay of opiate narcotics in urine and saliva.
Topics: Animals; Antibody Formation; Chromatography, Thin Layer; Electron Spin Resonance Spectroscopy; Free Radicals; Goats; Haptens; Humans; Immunoassay; Methadone; Methods; Morphine; Opium; Rabbits; Saliva; Structure-Activity Relationship; Substance-Related Disorders | 1972 |
Interferon inhibition by narcotic analgesics.
Topics: Animals; Body Temperature; Depression, Chemical; Diverticulum, Colon; Dose-Response Relationship, Drug; Endotoxins; Interferon Inducers; Interferons; L Cells; Male; Methadone; Mice; Morphine; Poly I-C; Vesicular stomatitis Indiana virus | 1973 |
Homogenous immunochemical drug assays.
Topics: Amphetamine; Antigen-Antibody Reactions; Barbiturates; Binding Sites, Antibody; Cocaine; Electron Spin Resonance Spectroscopy; Glucuronates; Heroin; Humans; Immunoassay; Methadone; Methods; Morphine; Muramidase; Pharmaceutical Preparations; Spectrophotometry; Substance-Related Disorders | 1973 |
Immunological assays for drugs in biological samples.
Topics: Amphetamine; Antibody Specificity; Antigen-Antibody Reactions; Barbiturates; Binding Sites, Antibody; Cross Reactions; Electron Spin Resonance Spectroscopy; Hemagglutination Inhibition Tests; Humans; Immunoassay; Iodine Isotopes; Methadone; Methods; Morphine; Muramidase; Pharmaceutical Preparations; Radioimmunoassay; Spectrophotometry; Substance-Related Disorders | 1973 |
Experiences with ESR as a tool for surveying narcotic addiction.
Topics: Animals; Antibodies; Antigen-Antibody Reactions; Chromatography, Thin Layer; Cocaine; Codeine; Electron Spin Resonance Spectroscopy; Evaluation Studies as Topic; Glucuronates; Heroin; Humans; Mass Screening; Methadone; Methods; Morphine; Rabbits; Saliva; Spin Labels; Substance-Related Disorders; Time Factors | 1973 |
Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.
Topics: Adenosine Triphosphate; Animals; Brain; Cyclic AMP; Heroin; In Vitro Techniques; Methadone; Morphinans; Morphine; Naloxone; Prostaglandin Antagonists; Rats; Tritium | 1974 |
Effects of acute and chronic adminstration of narcotic analgesics on growth hormone and corticotrophin (ACTH) secretion in rats.
Topics: Adrenocorticotropic Hormone; Animals; Dose-Response Relationship, Drug; Growth Hormone; Male; Methadone; Morphine; Nalorphine; Naloxone; Rats | 1973 |
[On the inhibitory effect of kinins on isolated intestinal sections].
Topics: Anesthetics, Local; Animals; Atropine; Bradykinin; Caffeine; Duodenum; Ganglionic Blockers; Guanethidine; Ileum; Jejunum; Kallidin; Meperidine; Methadone; Morphine; Phenylbutazone; Rabbits | 1966 |
Structural requirement for antitussive activity in some novel 16-substituted derivatives of 6,14-endoethenotetrahydrothebaine.
Topics: Analgesia; Animals; Antitussive Agents; Cats; Codeine; Cough; Guinea Pigs; Methadone; Morphinans; Morphine; Rats | 1968 |
Screening method for detection of drugs of abuse in human urine.
Topics: Alkaloids; Amphetamine; Analgesics; Barbiturates; Chlorpheniramine; Chromatography; Chromatography, Thin Layer; Codeine; Dextropropoxyphene; Histamine H1 Antagonists; Hot Temperature; Humans; Indicators and Reagents; Isonipecotic Acids; Meperidine; Methadone; Methods; Morphinans; Morphine; Pentazocine; Phenacetin; Phenothiazines; Quinidine; Substance-Related Disorders; Ultraviolet Rays | 1971 |
Liquid-solid extraction of lyophilized biological material for forensic analysis. I. Application to urine samples for detection of drugs of abuse.
Topics: Acetates; Antidepressive Agents; Barbiturates; Chromatography, Thin Layer; Forensic Medicine; Freeze Drying; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Meperidine; Methadone; Methods; Morphine; Substance-Related Disorders | 1971 |
The action of choline on the superior cervical ganglion of the cat.
Topics: Animals; Atropine; Autonomic Fibers, Postganglionic; Autonomic Fibers, Preganglionic; Cats; Choline; Cocaine; Denervation; Dimethylphenylpiperazinium Iodide; Drug Synergism; Electric Stimulation; Female; Ganglia, Autonomic; Ganglionic Blockers; Ganglionic Stimulants; Hexamethonium Compounds; Male; Methadone; Morphine; Nicotine; Nictitating Membrane; Sensory Receptor Cells | 1972 |
Effects of narcotic analgesics on contractions of the chick isolated, innervated oesophagus.
Topics: Acetylcholine; Analgesics; Animals; Chickens; Cyclazocine; Dextropropoxyphene; Electric Stimulation; Esophagus; Heroin; In Vitro Techniques; Meperidine; Methadone; Morphinans; Morphine; Muscle Contraction; Nalorphine; Pentazocine; Phenazocine; Serotonin; Tachyphylaxis; Time Factors | 1972 |
A single-dose suppression test in morphine-dependent mice.
Topics: Aminopyrine; Analgesics; Animals; Behavior, Animal; Humans; Isonipecotic Acids; Levorphanol; Male; Methadone; Mice; Morphinans; Morphine; Morphine Dependence; Motor Activity; Nalorphine; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome | 1974 |
Letter: A rapid assay of affinity for the narcotic receptor in rat brain: application to methadone analogues.
Topics: Alcohols; Analgesia; Animals; Brain; Culture Media; Dextromoramide; Isomerism; Methadone; Methods; Morphine; Rats; Receptors, Drug; Synaptic Membranes | 1974 |
The increased efficacy of narcotic antagonists induced by various narcotic analgesics.
Topics: Analgesics; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Synergism; Levorphanol; Male; Methadone; Mice; Morphinans; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Reaction Time; Time Factors | 1974 |
Methadone maintenance treatment. A report on over three years experience.
Topics: Adolescent; Adult; Aged; Community Mental Health Services; Female; Health Facilities; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Minnesota; Morphine; Substance-Related Disorders | 1974 |
Blood and tissue concentrations of drugs associated with fatalities.
Topics: Adolescent; Adult; Age Factors; Autopsy; Barbiturates; Brain Chemistry; Bronchopneumonia; Child; Chloroquine; Dextropropoxyphene; Drug Interactions; Female; Glutethimide; Humans; Kidney; Liver; Male; Meprobamate; Methadone; Morphine; Salicylates; Sex Factors; Substance-Related Disorders | 1974 |
Optimization of extraction and separation of narcotics from urine.
Topics: Chromatography, Gas; Chromatography, Thin Layer; Cocaine; Codeine; Diphenhydramine; Evaluation Studies as Topic; Glucosidases; Humans; Indicators and Reagents; Meperidine; Methadone; Methaqualone; Methods; Morphine; Nalorphine; Narcotics; Nicotine; Pentazocine; Phenmetrazine; Time Factors | 1974 |
Radioimmunoassay: its application to drugs of abuse.
Topics: Amphetamine; Animals; Antibody Formation; Antigen-Antibody Complex; Antigen-Antibody Reactions; Barbiturates; Body Fluids; Cocaine; Dronabinol; Humans; Lysergic Acid Diethylamide; Methadone; Morphine; Pentobarbital; Radioimmunoassay; Radioisotopes; Substance-Related Disorders | 1974 |
Transport and interaction of drugs in leukocytes.
Topics: Amines; Amphetamine; Animals; Biological Transport, Active; Codeine; Drug Interactions; Fluorides; In Vitro Techniques; Kinetics; Leukocytes; Male; Methadone; Morphine; Naloxone; Pentazocine; Rats; Temperature; Time Factors | 1974 |
Postpartum weight alteration in hamster offspring from females injected during pregnancy with either heroin, methadone, a composite drug mixture, or mescaline.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Cricetinae; Drug Combinations; Female; Heroin; Isoproterenol; Mescaline; Methadone; Morphine; Pregnancy; Trypan Blue; Vitamin A | 1974 |
Effect of acutely administered analgesic drugs on rat brain serotonin turnover.
Topics: Analgesics; Animals; Brain; Brain Chemistry; Clomipramine; Dopamine; Hydroxyindoleacetic Acid; Kinetics; Male; Meperidine; Methadone; Morphine; Naloxone; Nialamide; Norepinephrine; Pargyline; Pentazocine; Rats; Serotonin; Stimulation, Chemical; Tranylcypromine; Tryptophan | 1974 |
Chromatographic detection of narcotic antagonists in human urine.
Topics: Analgesics; Chromatography; Chromatography, Gas; Chromatography, Thin Layer; Cyclazocine; Humans; Hydrogen-Ion Concentration; Methadone; Morphine; Naloxone; Narcotic Antagonists; Solvents; Temperature | 1974 |
The effects of acutely administered analgesics on the turnover of noradrenaline and dopamine in various regions of the rat brain.
Topics: Analgesics; Animals; Brain; Corpus Striatum; Dopamine; Hypothalamus; Male; Medulla Oblongata; Methadone; Morphine; Norepinephrine; Pentazocine; Pons; Rats; Serotonin | 1974 |
Induction of physical dependence on morphine, codeine and meperidine in the rat by continuous infusion.
Topics: Animals; Behavior, Animal; Body Weight; Codeine; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Injections, Intraperitoneal; Male; Meperidine; Methadone; Morphine; Morphine Dependence; Nalorphine; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Vocalization, Animal | 1974 |
Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate.
Topics: Acetamides; Analgesics; Animals; Azides; Binding Sites; Binding, Competitive; Brain; Ethylmaleimide; Fluorides; In Vitro Techniques; Levorphanol; Male; Mercuribenzoates; Methadone; Morphinans; Morphine; Nalorphine; Naloxone; Pentanols; Phospholipases; Pronase; Prostaglandins; Rats; Receptors, Drug; Tritium; Trypsin | 1973 |
Modification of precipitated morphine and methadone abstinence in mice by acetylcholine antagonists.
Topics: Acetylcholine; Animals; Atropine; Drug Combinations; Humans; Mecamylamine; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1973 |
Urinalysis of 39,350 samples for drugs subject to abuse in a methadone maintenance treatment programme.
Topics: Barbiturates; Codeine; Humans; Mass Screening; Methadone; Morphine; Phenethylamines; Quinine; Substance-Related Disorders; United States | 1973 |
Correlates and extent of drug abuse on a methadone maintenance program.
Topics: Administration, Oral; Adult; California; Heroin Dependence; Humans; Male; Methadone; Morphine; Psychotherapy; Substance-Related Disorders; Time Factors | 1974 |
Negative direct Coombs' tests in narcotic addicts receiving maintenance doses of methadone.
Topics: Antibodies, Anti-Idiotypic; Chromatography, Gas; Chromatography, Thin Layer; Coombs Test; Fluorometry; Humans; Methadone; Morphine; Quinine; Substance-Related Disorders | 1972 |
Studies on physical dependence inducible by hours exposure of mice to morphine.
Topics: Analgesia; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Humans; Infusions, Parenteral; Injections; Male; Meperidine; Methadone; Mice; Morphine; Morphine Dependence; Motor Activity; Naloxone; Pentazocine; Substance Withdrawal Syndrome; Time Factors | 1972 |
Starch and talc emboli in drug addicts' lungs.
Topics: Acetaminophen; Adult; Alcohols; Amobarbital; Animals; Barbiturates; Female; Foreign-Body Reaction; Humans; Inflammation; Injections, Intravenous; Methadone; Morphine; Pentobarbital; Pulmonary Alveoli; Pulmonary Embolism; Rats; Secobarbital; Starch; Substance-Related Disorders; Talc; Time Factors | 1972 |
Hyperimmunoglobulinemia associated with narcotic addiction. Effects of methadone maintenance treatment.
Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Protein Disorders; Female; Hepatitis; Humans; Immunodiffusion; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Liver Cirrhosis; Male; Methadone; Middle Aged; Morphine; Serum Albumin; Substance-Related Disorders | 1973 |
Stability of certain drugs of abuse in urine specimens.
Topics: Amphetamine; Azides; Cocaine; Codeine; Drug Stability; Humans; Methadone; Morphine; Pharmaceutical Preparations; Phenobarbital; Secobarbital; Substance-Related Disorders; Temperature | 1972 |
Effects of acutely administered analgesic drugs on rat brain 5-hydroxytryptamine turnover.
Topics: Analgesics; Animals; Brain; Brain Chemistry; Hydroxyindoleacetic Acid; Male; Meperidine; Methadone; Morphine; Pargyline; Pentazocine; Probenecid; Rats; Serotonin | 1972 |
Effects of some narcotics and antagonists on synaptosomal 3 H-norepinephrine uptake.
Topics: Animals; Brain; Codeine; In Vitro Techniques; Methadone; Morphine; Nalorphine; Naloxone; Narcotics; Nerve Endings; Nerve Tissue Proteins; Norepinephrine; Pentobarbital; Pentylenetetrazole; Protein Binding; Rabbits; Synaptic Vesicles; Synaptosomes; Thebaine | 1972 |
The thin-layer chromatography of drugs. A laboratory experiment.
Topics: Alkaloids; Barbiturates; Chromatography, Thin Layer; Drug Combinations; Humans; Indicators and Reagents; Methadone; Methods; Morphine; Quinine; Substance-Related Disorders | 1972 |
What's happening in hard-drug rehabilitation?
Topics: Behavior; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Narcotic Antagonists; Psychotherapy; Reinforcement, Psychology; Substance-Related Disorders; Therapeutic Community; United States | 1973 |
Opiate receptor: demonstration in nervous tissue.
Topics: Analgesics; Animals; Atropine; Binding, Competitive; Brain; Carbachol; Codeine; Colchicine; Dextromethorphan; Dextropropoxyphene; Guinea Pigs; Histamine; Intestinal Mucosa; Levallorphan; Methadone; Mice; Morphine; Nalorphine; Naloxone; Phenazocine; Phenobarbital; Rats; Receptors, Drug; Serotonin; Tritium | 1973 |
Simple gas-liquid chromatographic method for confirming the presence of alkaloids in urine.
Topics: 1-Propanol; Chloroform; Chromatography, Gas; Cocaine; Codeine; Methadone; Methods; Morphine; Solubility | 1973 |
Analgesics and other drugs for relief of pain.
Topics: Analgesics; Aspirin; Azepines; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Indomethacin; Methadone; Morphine; Narcotics; Pain; Pentazocine; Pyrazoles; Salicylates; Substance-Related Disorders | 1973 |
Acute effects of narcotic analgesics on behavioral arousal in the rat.
Topics: Analgesics; Animals; Arousal; Dose-Response Relationship, Drug; Levorphanol; Locomotion; Male; Meperidine; Methadone; Methyltyrosines; Morphine; Narcotics; Pentazocine; Rats; Time Factors | 1973 |
Analysis for drugs of abuse: the validity of reported results in relation to performance testing.
Topics: Amphetamine; Barbiturates; Clinical Laboratory Techniques; Evaluation Studies as Topic; False Negative Reactions; False Positive Reactions; Humans; Laboratories; Licensure; Methadone; Morphine; Narcotics; New York; Phenothiazines; Quinine; Substance-Related Disorders; Urine | 1973 |
In vitro inhibitory effects of narcotic analgesics and other psychotropic drugs on the active uptake of norepinephrine in mouse brain tissue.
Topics: Animals; Atropine; Benztropine; Brain; Chlorpromazine; Cocaine; Codeine; Desipramine; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Levorphanol; Lipids; Meperidine; Methadone; Mice; Morphine; Naloxone; Narcotics; Norepinephrine; Solubility; Synaptosomes; Tritium | 1973 |
Separation of morphine alkaloids, heroin, methadone and other drugs by ion-exchange chromatography.
Topics: Acetaminophen; Aspirin; Autoanalysis; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Heroin; Methadone; Methods; Morphine; Opium; Phenacetin; Solvents | 1973 |
Agonistic properties of narcotic analgesics and antagonists on the electroencephalogram and behavior in the rat and their reversal by naloxone.
Topics: Analgesics; Animals; Behavior, Animal; Codeine; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Female; Meperidine; Methadone; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Sleep; Time Factors | 1973 |
Separation and quantitation of mixtures of the most commonly abused drugs.
Topics: Amobarbital; Cannabis; Chromatography, Thin Layer; Dextroamphetamine; Ephedrine; Humans; Indicators and Reagents; Lysergic Acid Diethylamide; Methadone; Methamphetamine; Methods; Morphine; Opium; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Secobarbital; Solvents; Spectrophotometry, Ultraviolet; Substance-Related Disorders | 1973 |
A sensitive, rapid radioimmunoassay for morphine and immunologically related substances in urine and serum.
Topics: Animals; Antibody Specificity; Chromatography, Thin Layer; Cross Reactions; Dextromethorphan; Female; Goats; Heroin Dependence; Humans; Immune Sera; Male; Methadone; Methods; Morphine; Radioimmunoassay; Tritium | 1973 |
The effect of narcotic analgesics on the homovanillic acid content of rat nucleus caudatus.
Topics: Analgesics; Animals; Behavior, Animal; Catalepsy; Caudate Nucleus; Codeine; Cyclazocine; Homovanillic Acid; Humans; Male; Methadone; Morphine; Muscle Tonus; Narcotics; Pentazocine; Phenylacetates; Rats; Structure-Activity Relationship | 1973 |
Some behavioral and EEG effects of a new analgesic agent (viminol) in comparison with morphine in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzyl Compounds; Butylamines; Conditioning, Operant; Dose-Response Relationship, Drug; Electroencephalography; Ethanolamines; Humans; Lethal Dose 50; Locomotion; Male; Meperidine; Meprobamate; Methadone; Morphine; Pyrroles; Rats; Substance-Related Disorders; Time Factors | 1973 |
The effect of narcotic analgesics on the uptake of 5-hydroxytryptamine and (-)-metaraminol by blood platelets.
Topics: Alphaprodine; Animals; Blood Platelets; Cyclazocine; Dextropropoxyphene; Humans; In Vitro Techniques; Isonipecotic Acids; Metaraminol; Methadone; Morphine; Nalorphine; Narcotics; Pentazocine; Rabbits; Serotonin; Serotonin Antagonists; Spectrometry, Fluorescence; Tritium | 1973 |
The effect of heroin and multiple drug abuse on the electrocardiogram.
Topics: Adolescent; Adult; Alcoholism; Barbiturates; Bradycardia; Cocaine; Death, Sudden; Electrocardiography; Female; Heart; Heart Rate; Heroin; Humans; Male; Methadone; Middle Aged; Morphine; Quinine; Substance-Related Disorders | 1973 |
Plasma testosterone in narcotic addiction.
Topics: Adult; Alcoholism; Aspartate Aminotransferases; Ejaculation; Heroin Dependence; Humans; Libido; Male; Methadone; Morphine; New York City; Prospective Studies; Quinine; Sexual Behavior; Testosterone; Time Factors | 1973 |
The action of hordenine on the superior cervical ganglion of the cat.
Topics: Adrenal Glands; Adrenalectomy; Animals; Atropine; Cats; Cocaine; Dimethylamines; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epinephrine; Female; Ganglia, Spinal; Hexamethonium Compounds; In Vitro Techniques; Male; Methadone; Morphine; Muscle Contraction; Nicotine; Nictitating Membrane; Phenethylamines; Propranolol; Receptors, Adrenergic; Receptors, Cholinergic; Time Factors | 1973 |
Stereospecific interaction of opiate narcotics in binding of 3H-dihydromorphine to membranes of rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Corpus Striatum; Dextromethorphan; Kinetics; Levorphanol; Male; Methadone; Morphine; Naloxone; Protein Binding; Rats; Receptors, Drug; Synaptosomes; Tritium | 1973 |
Application of high-speed liquid chromatography to the analysis of morphine, heroin, 6-(O-acetyl)morphine and methadone.
Topics: Autoanalysis; Chromatography, Ion Exchange; Heroin; Mass Spectrometry; Methadone; Methods; Morphine; Spectrophotometry, Ultraviolet | 1973 |
[Social conditions and use of drugs in a group of young addicts in Oslo].
Topics: Administration, Oral; Adolescent; Adult; Alcoholism; Amphetamine; Cannabis; Educational Status; Family; Female; Humans; Injections, Intravenous; Lysergic Acid Diethylamide; Male; Meperidine; Methadone; Morphine; Narcotics; Norway; Opium; Phenmetrazine; Social Problems; Socioeconomic Factors; Substance-Related Disorders; Time Factors; Unemployment | 1973 |
Interactions of narcotics and their antagonists with human serum esterase. IV. Drug-receptor interaction at the acceleratory site.
Topics: Alkylation; Esterases; Humans; Kinetics; Methadone; Models, Biological; Molecular Conformation; Morphinans; Morphine; Narcotic Antagonists; Narcotics; Piperidines; Receptors, Drug | 1973 |
Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats.
Topics: Animals; Codeine; Dextropropoxyphene; Meperidine; Mesencephalon; Methadone; Morphine; Rats; Serotonin | 1973 |
[Ionization constants of several narcotic analgesics and their pain relieving action].
Topics: Analgesics; Codeine; Dextromoramide; Dimethylamines; Diphenylacetic Acids; Ethers, Cyclic; Hydrogen-Ion Concentration; Ions; Kinetics; Levorphanol; Mathematics; Meperidine; Methadone; Morphinans; Morphine; Narcotics; Piperidines | 1973 |
Pathology and toxicology of drug addiction: a combined approach.
Topics: Adolescent; Adult; Bronchopneumonia; Female; Heroin Dependence; Humans; Kidney; Liver; Lung; Lymph Nodes; Male; Methadone; Middle Aged; Morphine; Spleen; Substance-Related Disorders; Tattooing | 1973 |
Contemporary trends in drug abuse in London as reflected by toxicological investigation of autopsy specimens.
Topics: Adult; Amphetamine; Autopsy; Barbiturates; Blood Chemical Analysis; Chromatography, Thin Layer; Female; Forensic Medicine; Humans; Kidney; Liver; London; Lung; Male; Methadone; Morphine; Social Problems; Spectrophotometry; Spleen; Substance-Related Disorders | 1973 |
Effects of narcotic analgesics and their antagonists on the rabbit isolated heart and its adrenergic nerves.
Topics: Animals; Autonomic Nervous System; Drug Interactions; Electric Stimulation; Female; Fentanyl; Heart; Heart Rate; In Vitro Techniques; Levallorphan; Male; Meperidine; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Norepinephrine; Perfusion; Rabbits; Secretory Rate; Sympathetic Nervous System | 1973 |
Cellular transport of CNS drugs in leukocytes.
Topics: Acetamides; Anaerobiosis; Animals; Azides; Biological Transport, Active; Brain; Carbon Radioisotopes; Cell Membrane; Dinitrophenols; Fluorides; Gelatin; Glycolysis; In Vitro Techniques; Kinetics; Leukocytes; Male; Methadone; Morphine; Narcotic Antagonists; Ouabain; Pentazocine; Rats; Temperature; Tritium | 1973 |
The interaction of 14C-morphine with sera from immunized rabbits and from patients addicted to heroin.
Topics: Adolescent; Adult; Animals; Antibodies; Antigen-Antibody Complex; Binding Sites, Antibody; Carbon Radioisotopes; Cattle; Dialysis; Female; Half-Life; Heroin Dependence; Humans; Kinetics; Male; Methadone; Middle Aged; Morphine; Rabbits; Radioimmunoassay | 1973 |
Insoluble salts and salt complexes of cyclazocine and naloxone.
Topics: Analgesics; Animals; Benzoates; Biopharmaceutics; Chemical Phenomena; Chemistry; Cyclazocine; Dosage Forms; Humans; Hydrogen-Ion Concentration; Methadone; Mice; Molecular Weight; Morphine; Naloxone; Salicylates; Salts; Spectrophotometry, Ultraviolet; Substance-Related Disorders; Suspensions; Tail; Tannins; Time Factors; Zinc | 1973 |
Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain.
Topics: Acetylcholine; Animals; Binding, Competitive; Brain Stem; Cerebral Cortex; Chloromercuribenzoates; Codeine; Dextromethorphan; Ethylmaleimide; Female; Heroin; In Vitro Techniques; Levorphanol; Methadone; Morphinans; Morphine; Nalorphine; Naloxone; Physostigmine; Rats; Receptors, Drug; Structure-Activity Relationship; Subcellular Fractions; Synaptic Membranes; Tritium | 1973 |
Anti-nociceptive activity of some thiophthalanes with morphine-like properties.
Topics: Analgesia; Analgesics; Animals; Bridged-Ring Compounds; Depression, Chemical; Dextropropoxyphene; Dimethylamines; Electric Stimulation; Ketones; Male; Meperidine; Methadone; Mice; Morphine; Pain; Piperidines; Thiophenes | 1973 |
Stereospecific interaction between narcotic analgesics and a synaptic plasm a membrane fraction of rat cerebral cortex.
Topics: Animals; Brain; Brain Chemistry; Cerebral Cortex; Methadone; Morphine; Rats; Receptors, Drug; Synaptic Membranes; Tritium | 1973 |
Physiologic implications of methadone treatment.
Topics: Adult; Alcoholism; Drug Tolerance; Electrocardiography; Female; Heroin Dependence; Hospitalization; Humans; Liver Diseases; Male; Methadone; Morphine; Morphine Dependence; Prospective Studies; Retrospective Studies; Substance Withdrawal Syndrome; United States | 1973 |
Studies on the use of XAD-2 resin for detection of abused drugs in urine.
Topics: Amobarbital; Amphetamine; Aspirin; Caffeine; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cocaine; Codeine; Evaluation Studies as Topic; Glucuronates; Humans; Hydrolysis; Meperidine; Meprobamate; Mescaline; Methadone; Methods; Microchemistry; Morphine; Nalorphine; Naloxone; Pentobarbital; Secobarbital; Substance-Related Disorders | 1974 |
Use of fluorescamine ("Fluram") to detect amphetamine in urine by thin-layer chromatography.
Topics: Amphetamine; Benzofurans; Chromatography, Ion Exchange; Chromatography, Thin Layer; Drug Stability; Evaluation Studies as Topic; Fluorescence; Glutethimide; Humans; Indicators and Reagents; Methadone; Methamphetamine; Methods; Microchemistry; Morphine; Pentobarbital; Phenobarbital; Phenothiazines; Quinine; Spiro Compounds; Substance-Related Disorders; Time Factors | 1974 |
Drug associations as a measure of habit strength for specific drugs.
Topics: Adult; Amphetamine; Association; Barbiturates; Cannabis; Culture; Ethanol; Heroin; Heroin Dependence; Humans; Male; Methadone; Morphine; Personality Inventory; Verbal Behavior; Word Association Tests | 1974 |
Thiazine dye antagonism of opioid lethality in mice.
Topics: Animals; Codeine; Dextropropoxyphene; Drug Synergism; Hexobarbital; Lethal Dose 50; Levorphanol; Male; Meperidine; Methadone; Methylene Blue; Mice; Morphinans; Morphine; Sleep; Thiazines; Time Factors; Tolonium Chloride | 1974 |
Evaluation of a latex agglutination-inhibition slide pregnancy test (Pregnosis).
Topics: Abortion, Spontaneous; Adolescent; Adult; Antidepressive Agents; Chorionic Gonadotropin; Codeine; Contraceptives, Oral; Diagnostic Errors; False Negative Reactions; False Positive Reactions; Female; Humans; Latex Fixation Tests; Male; Methadone; Morphine; Phenothiazines; Pregnancy; Pregnancy Complications; Pregnancy Tests, Immunologic; Pregnancy, Ectopic; Proteinuria | 1974 |
Methadone inhibition of 3H-5-hydroxytryptamine uptake by synaptosomes.
Topics: Animals; Brain; Centrifugation, Density Gradient; Cold Temperature; Dinitrophenols; Dose-Response Relationship, Drug; Hydroxyindoleacetic Acid; Imipramine; In Vitro Techniques; Kinetics; Male; Methadone; Monoamine Oxidase Inhibitors; Morphine; Naloxone; Ouabain; Potassium Chloride; Rabbits; Serotonin; Serotonin Antagonists; Sucrose; Synaptosomes; Tritium | 1974 |
Evaluation of deaths from drug overdose. A clinicopathologic study.
Topics: Accidents; Adolescent; Adult; Aged; Barbiturates; Child; Chloroquine; Dextropropoxyphene; Female; Glutethimide; Humans; Male; Meprobamate; Methadone; Middle Aged; Morphine; Poisoning; Pulmonary Edema; Salicylates; Suicide | 1974 |
A review of some GLD-FID derivitization techniques found useful in forensic toxicology.
Topics: Acetylation; Amphetamine; Bromides; Chromatography, Gas; Forensic Medicine; Formaldehyde; Glycols; Humans; Methadone; Methylation; Morphine; Oxidation-Reduction; Phenytoin; Toxicology | 1974 |
Chemical evaluation of 'drug cocktails' in autopsy specimens.
Topics: Adult; Amphetamine; Autopsy; Barbiturates; Body Fluids; Forensic Medicine; Hallucinogens; Humans; Hypnotics and Sedatives; Levallorphan; Male; Meperidine; Methadone; Methaqualone; Morphinans; Morphine; Pharmaceutical Preparations; Poisoning; Substance-Related Disorders; Tissue Extracts | 1974 |
The inhibition of the uptake of monoamines by blood platelets by phenothiazines and other drugs.
Topics: Animals; Antidepressive Agents; Atropine; Biogenic Amines; Blood Platelets; Carbon Radioisotopes; Cell Membrane; Cocaine; Depression, Chemical; Dibenzazepines; Dopamine; Hemolysis; In Vitro Techniques; Metaraminol; Methadone; Methylation; Morphine; Phenothiazines; Serotonin; Structure-Activity Relationship; Surface Tension; Tritium | 1974 |
Determination of the presence of morphine in urine.
Topics: Chromatography, Gas; Chromatography, Ion Exchange; Chromatography, Thin Layer; Evaluation Studies as Topic; Heroin Dependence; Humans; Methadone; Methods; Microchemistry; Morphine; Radioimmunoassay; Spectrometry, Fluorescence | 1974 |
Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline lambda-type Bence-Jones dimer.
Topics: Amino Acid Sequence; Amino Acids; Amyloidosis; Bence Jones Protein; Binding Sites; Caffeine; Chemical Phenomena; Chemistry; Colchicine; Dansyl Compounds; Fluorine; Humans; Immunoglobulin Fragments; Immunoglobulins; Iodine; Macromolecular Substances; Methadone; Models, Structural; Morphine; Nitrobenzenes; Phenanthrolines; Protein Binding; Protein Conformation; Uracil; Vitamin K; X-Ray Diffraction | 1974 |
Reciprocal (push-pull) effects of morphine on single units in the ventromedian and lateral hypothalamus and influences on other nuclei: with a comment on methadone effects during withdrawal from morphine.
Topics: Amygdala; Animals; Cerebral Cortex; Depression, Chemical; Drug Interactions; Electrophysiology; Humans; Hypothalamus; Methadone; Morphine; Morphine Dependence; Nalorphine; Naloxone; Neurons; Rats; Substance Withdrawal Syndrome; Time Factors | 1974 |
Methadone increases mouse brain 5-hydroxyindoleacetic acid.
Topics: Animals; Brain; Hydroxyindoleacetic Acid; Methadone; Mice; Morphine; Pargyline; Probenecid; Serotonin; Stimulation, Chemical | 1971 |
Confirmed identification of biotransformed drugs of abuse in urine.
Topics: Amphetamine; Analgesics; Barbiturates; Biotransformation; Caffeine; Cannabis; Chromatography, Gas; Chromatography, Thin Layer; Codeine; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Reagents; Methadone; Morphine; Nicotine; Pharmaceutical Preparations; Procaine; Skin; Spectrum Analysis; Substance-Related Disorders; Tranquilizing Agents | 1972 |
Mini thin-layer chromatography in the detection of narcotics in urine from subjects on a methadone maintenance program.
Topics: Chromatography, Thin Layer; Codeine; Colorimetry; Humans; Meperidine; Methadone; Methods; Morphine; Narcotics; Substance-Related Disorders | 1972 |
U.S. Army heroin abuse identification program in Vietnam: implications for a methadone program.
Topics: Chromatography, Gas; Chromatography, Thin Layer; False Positive Reactions; Heroin; Humans; Methadone; Military Medicine; Morphine; Morphine Dependence; Substance-Related Disorders; United States; Vietnam | 1972 |
Automated fluorometric method for the determination of morphine in urine.
Topics: Autoanalysis; Fluorometry; Humans; Methadone; Methods; Morphine | 1972 |
Simplified multiple sample urinalysis in support of a methadone clinic.
Topics: Amphetamine; Barbiturates; Chromatography, Thin Layer; Humans; Methadone; Morphine; Narcotics; Substance-Related Disorders | 1972 |
Relative degree of tolerance to morphine sulfate and methadone hydrochloride in the rat and the interaction of dexamethasone.
Topics: Analgesia; Animals; Body Weight; Dexamethasone; Drug Synergism; Drug Tolerance; Male; Methadone; Morphine; Prednisolone; Rats; Reaction Time; Triamcinolone Acetonide | 1972 |
Resumption of morphine self-administration by ex-addict rats: an attempt to modify tendencies to relapse.
Topics: Animals; Disease Models, Animal; Drinking Behavior; Humans; Male; Methadone; Morphine; Morphine Dependence; Quinine; Rats; Recurrence; Reinforcement, Psychology; Substance Withdrawal Syndrome; Taste | 1972 |
Morphine catalepsy in the rat: relation to striatal dopamine metabolism.
Topics: Animals; Apomorphine; Brain Chemistry; Catalepsy; Chlorpromazine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains | 1972 |
Treatment of morphine-type dependence by withdrawal methods.
Topics: Barbiturates; Female; Heroin; Hospitalization; Humans; Male; Meperidine; Methadone; Morphine; Pregnancy; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Tranquilizing Agents | 1972 |
Oral methadone maintenance techniques in the management of morphine-type dependence.
Topics: Female; Heroin; Hospitalization; Humans; Male; Methadone; Morphine; Pregnancy; Substance-Related Disorders | 1972 |
Human chromosomes and opiates.
Topics: Adult; Cells, Cultured; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Female; Heroin; Humans; In Vitro Techniques; Leukocytes; Male; Methadone; Middle Aged; Mitosis; Morphine; Morphine Dependence; Quinine; Substance-Related Disorders | 1972 |
Modifications of the XAD-2 resin column method for the extraction of drugs of abuse from human urine.
Topics: Amphetamine; Carbon Isotopes; Humans; Ion Exchange Resins; Methadone; Morphine; Phenobarbital; Tritium | 1972 |
Eosinophilia and drug abuse.
Topics: Amphetamine; Barbiturates; Cannabis; Cocaine; Codeine; Eosinophilia; Heroin; Humans; Lysergic Acid Diethylamide; Male; Mescaline; Methadone; Morphine; Substance-Related Disorders | 1972 |
Blood-brain barrier: penetration of morphine, codeine, heroin, and methadone after carotid injection.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Carbon Isotopes; Carotid Arteries; Codeine; Heroin; Injections, Intravenous; Mannitol; Methadone; Morphine; Rats; Time Factors; Tritium | 1972 |
Clinical implications of urine surveillance in a methadone maintenance program.
Topics: Adolescent; Adult; Amphetamine; Barbiturates; Evaluation Studies as Topic; Female; Humans; Male; Methadone; Morphine; Narcotics; Outpatient Clinics, Hospital; Probability; Seasons; Substance-Related Disorders | 1972 |
Detection of morphine by hemagglutination-inhibition.
Topics: Absorption; Antigens; Hemagglutination Inhibition Tests; Hemagglutination Tests; Humans; Immune Sera; Methadone; Morphine; Radioimmunoassay | 1971 |
Action of picric acid on the effects of some drugs acting on the central nervous system, with special reference to opioids.
Topics: Amphetamine; Analgesia; Analgesics; Animals; Benzimidazoles; Drug Synergism; Female; Male; Meperidine; Methadone; Mice; Microsomes, Liver; Morphine; Pentazocine; Pentylenetetrazole; Picrates; Seizures; Sleep; Sodium Salicylate | 1971 |
An implanted reservoir of morphine solution for rapid induction of physical dependence in rats.
Topics: Animals; Body Weight; Codeine; Cyclazocine; Defecation; Female; Humans; Injections, Subcutaneous; Methadone; Methods; Morphine; Nalorphine; Pentazocine; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1971 |
Detection of drugs in urine for methadone treatment programs.
Topics: Amphetamine; Analgesics; Barbiturates; Chromatography, Gas; Chromatography, Thin Layer; Drug and Narcotic Control; Humans; Mass Screening; Methadone; Methods; Morphine; Narcotics; Quinine; Substance-Related Disorders | 1971 |
Development of behavioral tolerance to morphine and methadone using the schedule-controlled behavior of the pigeon.
Topics: Animals; Appetitive Behavior; Behavior, Animal; Columbidae; Drug Tolerance; Humans; Male; Methadone; Morphine; Reinforcement Schedule; Substance Withdrawal Syndrome | 1971 |
The biochemical pharmacology of tolerance to opioid analgesics.
Topics: Animals; Brain; Dactinomycin; Drug Tolerance; Methadone; Morphine; Nalorphine; Protein Biosynthesis; Rats | 1971 |
Gas chromatographic detection of methadone and morphine in the urine of drug addicts.
Topics: Chromatography, Gas; Chromatography, Thin Layer; Humans; Methadone; Morphine; Substance-Related Disorders | 1971 |
The action of arecoline on the superior cervical ganglion of the cat.
Topics: Animals; Atropine; Cats; Cocaine; Dimethylphenylpiperazinium Iodide; Drug Antagonism; Female; Ganglia, Autonomic; Ganglionic Stimulants; Male; Methadone; Morphine; Nicotine; Nicotinic Acids; Nictitating Membrane; Parasympathomimetics; Piperazines; Receptors, Drug; Stimulation, Chemical; Sympathetic Nervous System | 1971 |
Effects of narcotic analgesics and antagonists on the in vivo release of acetylcholine from the cerebral cortex of the cat.
Topics: Acetylcholine; Analgesia; Analgesics; Animals; Bridged-Ring Compounds; Cats; Cerebral Cortex; Chlorpromazine; Codeine; Dextropropoxyphene; Female; Furans; Ketones; Levallorphan; Male; Meperidine; Methadone; Morphine; Nalorphine; Narcotic Antagonists; Pentazocine; Phenanthrenes | 1971 |
[Pharmacotherapy of morphine addiction].
Topics: Bridged-Ring Compounds; Humans; Methadone; Morphine; Morphine Dependence; Substance Withdrawal Syndrome | 1971 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: American Medical Association; Female; Health Education; Heroin; Humans; Legislation, Drug; Methadone; Morphinans; Morphine; Morphine Dependence; Pain; Personality; Pregnancy; Pregnancy Complications; Socioeconomic Factors; Substance Withdrawal Syndrome; United States | 1971 |
Methadone treatment of heroin addicts. Early results provide more questions than answers.
Topics: Follow-Up Studies; Heroin; Humans; Methadone; Morphine; Quinine; Substance-Related Disorders; Time Factors | 1971 |
Determination of drugs in biologic specimens.
Topics: Analgesics; Antidepressive Agents; Barbiturates; Body Fluids; Chromatography, Gas; Chromatography, Thin Layer; Drug and Narcotic Control; Hallucinogens; Humans; Hypnotics and Sedatives; Mass Screening; Methadone; Morphine; Pharmaceutical Preparations; Spectrophotometry; Substance-Related Disorders; Tissue Extracts; Toxicology; Tranquilizing Agents; Ultraviolet Rays | 1970 |
Absence of major medical complications among chronic opiate addicts.
Topics: Age Factors; Aged; Codeine; Heroin; Humans; Injections; Male; Methadone; Middle Aged; Morphine; Opium; Patient Readmission; Phenytoin; Substance-Related Disorders; Time Factors | 1970 |
Factors influencing the incidence of reversible lens opacities in solitary and aggregated mice.
Topics: Animals; Blepharoptosis; Body Temperature; Carbon Dioxide; Cataract; Crowding; Environment; Female; Lactates; Male; Methadone; Mice; Morphine; Movement; Physical Exertion; Social Isolation | 1969 |
[Principles and risks of drug treatment of pain].
Topics: Aminopyrine; Analgesics; Antidepressive Agents; Antipyrine; Aspirin; Codeine; Dibenzazepines; Humans; Imipramine; Levallorphan; Levorphanol; Methadone; Morphine; Pain; Phenacetin; Phenylbutazone; Pyrazoles; Salicylamides; Salicylates; Sulfonic Acids | 1969 |
Studies of drugs given before anaesthesia. XIX. The opiates.
Topics: Analgesics; Diazepam; Female; Fentanyl; Heroin; Humans; Levorphanol; Male; Meperidine; Methadone; Morphine; Papaverine; Phenazocine; Preanesthetic Medication; Vomiting | 1970 |
Drug action on tail shock-induced vocalization in mice and its relevance to analgesia.
Topics: Analgesia; Animals; Cerebral Cortex; Chlorpromazine; Codeine; Cyclazocine; Electric Stimulation; Hydroxyzine; Levallorphan; Male; Methadone; Methotrimeprazine; Mice; Morphinans; Morphine; Nalorphine; Narcotic Antagonists; Narcotics; Pentazocine; Tail; Tranquilizing Agents; Vocalization, Animal | 1970 |
Oxygen, carbon dioxide, and pH responses in arterial blood of dogs given analgesic, neuroleptanalgesic, and ataractic agents.
Topics: Analgesics; Animals; Arteries; Atropine; Carbon Dioxide; Dogs; Hydrogen-Ion Concentration; Meperidine; Methadone; Morphine; Narcotics; Neuroleptanalgesia; Oxygen; Pentazocine; Respiration; Respiratory Function Tests; Tranquilizing Agents | 1970 |
The "staircase maze" and the "simple staircase" in the analysis of the psychopharmacological action of CNS depressants.
Topics: Analgesics; Animals; Barbiturates; Behavior, Animal; Central Nervous System; Chlorpromazine; Hydroxyzine; Hypnotics and Sedatives; Meperidine; Methadone; Morphine; Paraldehyde; Pentobarbital; Phenobarbital; Rats; Reserpine; Tranquilizing Agents | 1970 |
Quantitative studies on the antagonism by naloxone of some narcotic and narcotic-antagonist analgesics.
Topics: Animals; Bridged-Ring Compounds; Cyclazocine; Furans; Ketones; Levorphanol; Male; Methadone; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pentazocine; Phenanthrenes; Quinones; Receptors, Drug; Spasm | 1970 |
Studies on the receptors involved in the action of the various agents in the phenylbenzoquinone analgesic assay in mice.
Topics: Analgesics; Animals; Aspirin; Atropine; Cyclazocine; Drug Tolerance; Levorphanol; Male; Methadone; Mice; Morphine; Nalorphine; Pentazocine; Physostigmine; Quinones; Receptors, Drug; Spasm | 1970 |
[Deaths in drug addicts. Forensic chemical studies and toxicological considerations].
Topics: Adolescent; Adult; Barbiturates; Blood Chemical Analysis; Central Nervous System; Denmark; Dextropropoxyphene; Drug Synergism; Forensic Medicine; Humans; Liver; Male; Methadone; Morphine; Parasympatholytics; Substance-Related Disorders; Tranquilizing Agents; Urine | 1970 |
Antagonism of the behavioral effects of morphine and methadone by narcotic antagonists in the pigeon.
Topics: Animals; Behavior, Animal; Chlorpromazine; Columbidae; Cyclazocine; Dextroamphetamine; Drug Synergism; Male; Methadone; Morphinans; Morphine; Nalorphine; Narcotic Antagonists; Pentazocine | 1970 |
The effects of morphine-like compounds on the light responses of the brine shrimp Artemia salina.
Topics: Animals; Decapoda; Levorphanol; Light; Methadone; Methods; Morphinans; Morphine; Nalorphine; Pentobarbital; Time Factors | 1970 |
Influence of morphine, methadone and methadone isomers on some effects of smooth muscle stimulants.
Topics: Acetylcholine; Animals; Barium; Bradykinin; Capillary Permeability; Depression, Chemical; Female; Guinea Pigs; Ileum; Isomerism; Methadone; Morphine; Muscle Contraction; Muscle, Smooth; Rats; Serotonin Antagonists; Stereoisomerism; Structure-Activity Relationship; Substance P; Uterus | 1970 |
[Acute tolerance to continuous subcutaneous infusion of morphine].
Topics: Analgesia; Animals; Drug Tolerance; Heart Rate; Injections, Subcutaneous; Male; Meperidine; Methadone; Mice; Morphine | 1970 |
The necessity of elution and identification of drugs indicated by thin-layer chromatography.
Topics: Benzamides; Chlorpromazine; Chromatography, Thin Layer; Dextropropoxyphene; Humans; Indicators and Reagents; Methadone; Methods; Morphine; Narcotics; Nicotine; Pharmaceutical Preparations; Procaine; Quinine | 1971 |
Pharmacology of narcotics and antagonists as related to drug abuse.
Topics: Codeine; Heroin; Humans; Levallorphan; Meperidine; Methadone; Morphine; Morphine Dependence; Nalorphine; Narcotic Antagonists; Stereoisomerism; Substance-Related Disorders | 1971 |
Effects of narcotic analgesics upon the locomotor activity and brain catecholamine content of the mouse.
Topics: Animals; Brain; Brain Chemistry; Catecholamines; Dextroamphetamine; Drug Tolerance; Levorphanol; Locomotion; Male; Methadone; Mice; Morphinans; Morphine; Motor Activity; Narcotics; Thebaine | 1971 |
[Method of measuring analgesic activity in the rat].
Topics: Analgesics; Animals; Electric Stimulation; Methadone; Morphine; Rats | 1967 |
[The effects of spasmolytics on the mechanical and electrical activity of isolated rat uterus].
Topics: Acetylcholine; Action Potentials; Animals; Depression, Chemical; Female; In Vitro Techniques; Meperidine; Methadone; Morphine; Muscle Contraction; Muscles; Papaverine; Rats; Scopolamine; Stimulation, Chemical; Uterus | 1967 |
Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.
Topics: Analgesia; Animals; Brain; Codeine; Dextropropoxyphene; Electroshock; Male; Methadone; Morphine; Pain; Phenylalanine; Rats; Serotonin; Serotonin Antagonists | 1968 |
The addiction cycle to narcotics in the rat and its relation to catecholamines.
Topics: Adrenal Glands; Animals; Body Weight; Brain; Drug Tolerance; Epinephrine; Female; Growth; Humans; Levorphanol; Methadone; Monoamine Oxidase Inhibitors; Morphine; Morphine Dependence; Norepinephrine; Organ Size; Rats; Stimulation, Chemical; Substance Withdrawal Syndrome; Substance-Related Disorders; Thebaine; Time Factors | 1968 |
[On characterization of the bradykinin effect on smooth muscle].
Topics: Animals; Bradykinin; Bronchi; Codeine; Fentanyl; Guinea Pigs; Ileum; Levallorphan; Methadone; Morphine; Muscle, Smooth; Nalorphine; Piperidines; Thebaine | 1968 |
The antidiuretic effect of narcotic analgesics in the mouse.
Topics: Animals; Biological Assay; Diuresis; Drug Antagonism; Fentanyl; Levorphanol; Methadone; Mice; Morphine; Nalorphine; Water | 1968 |
[Addiction treatment center at Ulleråker. 1. Drug addiction control].
Topics: Amphetamine; Barbiturates; Dextromoramide; Female; Hospitals, Psychiatric; Humans; Male; Methadone; Morphinans; Morphine; Narcotics; Phenmetrazine; Substance-Related Disorders | 1969 |
Thin-layer chromatographic detection of barbiturates, narcotics, and amphetamines in urine of patients receiving psychotropic drugs.
Topics: Amphetamine; Barbiturates; Chlorpromazine; Chromatography, Thin Layer; Cocaine; Codeine; Humans; Imipramine; Ion Exchange Resins; Meperidine; Methadone; Morphine; Narcotics; Quinine; Thioridazine; Trifluoperazine | 1969 |
The specific assay of basic drugs in urine by CM-cellulose chromatography using continuous drug-dye complex extraction as a detection system.
Topics: Amphetamine; Buffers; Cellulose; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Coloring Agents; Cyclizine; Ephedrine; Guanethidine; Guanidines; Hydrogen-Ion Concentration; Meperidine; Methadone; Morphine; Spectrophotometry; Strychnine | 1969 |
Agonist and antagonist interactions of opioids on acetic acid-induced abdominal stretching in mice.
Topics: Acetates; Analgesia; Animals; Behavior, Animal; Drug Antagonism; Drug Synergism; Drug Tolerance; Male; Methadone; Mice; Morphinans; Morphine; Muscles; Nalorphine; Narcotic Antagonists; Narcotics; Pentazocine; Reserpine; Tetrabenazine | 1969 |
The responses of the terminal bile duct to morphine and morphine-like drugs.
Topics: Ampulla of Vater; Animals; Bile Ducts; Cats; Cattle; Dextromoramide; Dogs; In Vitro Techniques; Levorphanol; Meperidine; Methadone; Morphine; Tachyphylaxis | 1965 |
The analgesic effect of opiate-opiate antagonist combinations in the rat.
Topics: Analgesics; Animals; Levallorphan; Meperidine; Methadone; Morphine; Nalorphine; Narcotic Antagonists; Phenazocine; Rats; Sensory Receptor Cells | 1965 |
Release of intestinal 5-hydroxytryptamine by morphine and related agents.
Topics: Acetylcholine; Animals; Apomorphine; Calcium; Cocaine; Dogs; Female; Guinea Pigs; Ileum; Injections, Intravenous; Intestinal Mucosa; Intestines; Levorphanol; Male; Meperidine; Methadone; Morphine; Nalorphine; Nicotine; Rats; Reserpine; Serotonin; Tachyphylaxis; Uterus | 1967 |
Oxygen consumption in the new-born rat and the effects of maternally administered analgesics.
Topics: Analgesics; Animals; Animals, Newborn; Female; Maternal-Fetal Exchange; Meperidine; Methadone; Morphine; Oxygen Consumption; Pregnancy; Rats | 1967 |
Responses of isolated dog small intestine to analgesic agents.
Topics: Analgesics; Animals; Cyclazocine; Dogs; Gastrointestinal Motility; In Vitro Techniques; Intestinal Secretions; Intestine, Small; Methadone; Morphine; Muscle Contraction; Muscle, Smooth; Pentazocine; Serotonin | 1967 |
Antagonistic action of tolazoline upon the analgesic effect of some morphine analogues.
Topics: Analgesia; Animals; Drug Antagonism; Meperidine; Methadone; Morphine; Phenazocine; Rats; Tolazoline | 1967 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: Amphetamine; Barbiturates; Cannabis; Drug and Narcotic Control; Female; Heroin; Humans; Legislation, Drug; Male; Methadone; Morphine; Nalorphine; Pregnancy; Substance Withdrawal Syndrome; Substance-Related Disorders; United States | 1967 |
New, simple method for the informative investigation of sedatives.
Topics: Amphetamine; Animals; Chlordiazepoxide; Chlorpromazine; Diazepam; Escape Reaction; Glutethimide; Haloperidol; Hypnotics and Sedatives; Imipramine; Male; Meprobamate; Methadone; Methods; Mice; Morphine; Nialamide; Pentobarbital; Phenobarbital; Reserpine; Tubocurarine; Urethane | 1967 |
Inhibition of the cardiac response to sympathetic nerve stimulation by opioid peptides and its potentiation by morphine and methadone.
Topics: Animals; beta-Endorphin; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Guinea Pigs; Heart; In Vitro Techniques; Male; Methadone; Morphine; Myocardial Contraction; Norepinephrine; Sympathetic Nervous System | 1984 |
Involvement of endogenous opioid systems in social behavior of individually-housed mice.
Topics: Aggression; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Methadone; Mice; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Receptors, Opioid; Social Behavior; Social Isolation | 1984 |
Differential neuropharmacological effects of mu, kappa and sigma opioid agonists on cortical EEG power spectra in the rat. Stereospecificity and naloxone antagonism.
Topics: Animals; Cerebral Cortex; Cyclazocine; Electroencephalography; Ethylketocyclazocine; Female; Methadone; Molecular Conformation; Morphine; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma | 1984 |
Studies on action mechanisms of morphine and 1-methadone in mice.
Topics: Animals; Brain; Drug Tolerance; In Vitro Techniques; Male; Methadone; Mice; Morphine; Nociceptors; Receptors, Opioid | 1984 |
Behavioral activating effects of opiates and opioid peptides.
Topics: Animals; Benzimidazoles; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Exploratory Behavior; Male; Methadone; Mice; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1980 |
[Pain-relieving agents. 2].
Topics: Analgesics; Analgesics, Opioid; Drug Tolerance; Humans; Meperidine; Methadone; Morphine; Morphine Derivatives; Substance-Related Disorders | 1980 |
The effects of opiates on androgen binding in the forebrain of the rat.
Topics: Animals; Autoradiography; Centrifugation, Density Gradient; Cytosol; Diencephalon; Dihydrotestosterone; Female; Hydroxyapatites; Limbic System; Luteinizing Hormone; Methadone; Morphine; Rats; Receptors, Androgen; Receptors, Estrogen; Receptors, Steroid | 1980 |
Morphine and methadone binding to human serum proteins.
Topics: Blood Proteins; Humans; Kinetics; Methadone; Morphine; Protein Binding | 1980 |
Comparative cardiac contractile actions of six narcotic analgesics: morphine, meperidine, pentazocine, fentanyl, methadone and l-alpha-acetylmethadol (LAAM).
Topics: Analgesics, Opioid; Animals; Cats; Depression, Chemical; Drug Interactions; Fentanyl; Meperidine; Methadone; Methadyl Acetate; Morphine; Myocardial Contraction; Naloxone; Pentazocine; Stimulation, Chemical | 1980 |
Occurrence of corneal opacities in rats after acute administration of l-alpha-acetylmethadol.
Topics: Analgesics, Opioid; Animals; Cornea; Corneal Opacity; Dose-Response Relationship, Drug; Male; Methadone; Methadyl Acetate; Morphine; Pupil; Rats | 1980 |
Pharmaceutics: choice of a strong analgesic for cancer patients.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain, Intractable | 1982 |
Differential analgesic cross-tolerance to morphine between lipophilic and hydrophilic narcotic agonists.
Topics: Analgesics, Opioid; Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Injections, Intraventricular; Injections, Subcutaneous; Male; Methadone; Mice; Morphine; Morphine Derivatives; Narcotics; Receptors, Opioid | 1984 |
Strong analgesics in severe pain.
Topics: Analgesics, Opioid; Chronic Disease; Cocaine; Fentanyl; Half-Life; Heroin; Humans; Injections, Intramuscular; Methadone; Morphine; Pain, Intractable; Pain, Postoperative | 1984 |
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesthesia, Conduction; Animals; Burns; Cyclooxygenase Inhibitors; Fentanyl; Half-Life; Humans; Methadone; Models, Chemical; Morphine; Narcotics; Nerve Block; Pain; Pain Management; Propranolol | 1984 |
Analgesic effect of opiates in offspring of opiate-treated female rats.
Topics: Analgesics, Opioid; Animals; Female; Male; Methadone; Morphine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reaction Time; Sex Factors | 1984 |
Opiates and thermoregulation in mice. I. Agonists.
Topics: Animals; Benzimidazoles; Body Temperature Regulation; Codeine; Dose-Response Relationship, Drug; Etorphine; Fentanyl; Hydromorphone; Isonipecotic Acids; Levorphanol; Male; Meperidine; Methadone; Mice; Morphine; Narcotics; Oxymorphone | 1980 |
Clinical effects of parenteral narcotics in hospitalized medical patients.
Topics: Codeine; Drug Utilization; Female; Humans; Hydromorphone; Injections; Male; Methadone; Morphine; Narcotics; Opium | 1980 |
Interaction of opiates with dopamine receptors: receptor binding and behavioral assays.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butaclamol; Dibenzocycloheptenes; Haloperidol; Kinetics; Male; Methadone; Morphine; Naloxone; Rats; Receptors, Dopamine; Spiperone | 1982 |
Methadone and intravenous morphine requirements. Treatment of pain due to advanced cancer.
Topics: Adolescent; Adult; Aged; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable; Palliative Care | 1983 |
The effects of opiate agonists on growth hormone and prolactin release in rats.
Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate | 1980 |
Opioid mechanisms in regulation of cerebral monoamines in vivo.
Topics: Animals; Biogenic Amines; Brain; Dopamine; Drug Tolerance; Male; Methadone; Morphine; Rats; Receptors, Opioid; Serotonin | 1980 |
Buprenorphrine: demonstration of physical dependence liability.
Topics: Animals; Buprenorphine; Drug Tolerance; Humans; Male; Methadone; Morphinans; Morphine; Naloxone; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
Central effects of morphine, levorphanol, (-)-methadone and the opioid-like peptides beta-endorphin and D-alanine2- methionine enkephalinamide on urine volume outflow and electrolytes.
Topics: Animals; beta-Endorphin; Brain; Diuresis; Electrolytes; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Levorphanol; Male; Methadone; Morphine; Naloxone; Narcotics; Rats; Vasopressins | 1981 |
A comparison of antinociception induced by foot shock and morphine.
Topics: Animals; Cyclazocine; Electroshock; Foot; Male; Methadone; Morphine; Naloxone; Nociceptors; Pain; Pentazocine; Perception; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord; Time Factors | 1983 |
Relationship of duration of analgesia to opioid pharmacokinetic variables.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Fentanyl; Half-Life; Male; Metabolic Clearance Rate; Methadone; Morphine; Narcotics; Nociceptors; Rats; Receptors, Opioid | 1983 |
Differential behavioral effects induced by intrathecal microinjection of opiates: comparison of convulsive and cataleptic effects produced by morphine, methadone, and D-Ala2-methionine-enkephalinamide.
Topics: Animals; Arousal; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Enkephalin, Methionine; Evoked Potentials; Injections, Spinal; Male; Methadone; Morphine; Motor Activity; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures; Spinal Cord | 1984 |
Cataleptic effects of opiates following intrathecal administration.
Topics: Animals; Arousal; Dose-Response Relationship, Drug; Enkephalin, Methionine; Hindlimb; Injections, Spinal; Male; Methadone; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Spinal Cord | 1984 |
Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites.
Topics: Animals; Cerebral Cortex; Drug Tolerance; Electroencephalography; Enkephalin, Methionine; Evoked Potentials; Injections, Intraventricular; Male; Methadone; Morphine; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Seizures | 1984 |
Effects of opioids on accuracy of a fixed-ratio discrimination in monkeys and rats.
Topics: Animals; Buprenorphine; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Erythrocebus patas; Ethylketocyclazocine; Isomerism; Macaca mulatta; Male; Methadone; Morphinans; Morphine; Phenazocine; Rats | 1984 |
Initial opiate use and treatment outcome in methadone detoxification patients.
Topics: Humans; Hypnotics and Sedatives; Male; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Socioeconomic Factors | 1983 |
No evidence for a protracted change in endogenous opioid activity following chronic opiate treatment in mice: parallel recovery of cross tolerance to stress and morphine antinociception.
Topics: Animals; Drug Tolerance; Endorphins; Female; Humans; Methadone; Mice; Morphine; Nociceptors; Reaction Time; Stress, Psychological | 1984 |
Phenomenology and theoretical basis of tolerance and dependence.
Topics: Adaptation, Psychological; Behavior; Chemoreceptor Cells; Drug Tolerance; Hemodynamics; Humans; Male; Methadone; Morphine; Respiration; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Various factors which affect the rate of development of tolerance and physical dependence to abused drugs.
Topics: Animals; Body Weight; Drug Tolerance; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Reaction Time; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1984 |
Evidence of serotonin-dopamine involvement in the inhibition of d-amphetamine stereotypy and appearance of stereotyped movements found respectively after acute and long-term treatment with morphine and methadone in rats.
Topics: Animals; Brain; Dextroamphetamine; Dopamine; Fenclonine; Fenfluramine; Haloperidol; Humans; Male; Methadone; Methylphenidate; Morphine; Piperazines; Rats; Serotonin; Stereotyped Behavior | 1981 |
Feline analgesia following central administration of opioids.
Topics: Analgesia; Animals; Cats; Etorphine; Injections, Subcutaneous; Male; Methadone; Microinjections; Morphine; Narcotics; Periaqueductal Gray; Reaction Time | 1984 |
Characterization of stress-induced potentiation of opioid effects in the rat.
Topics: Analgesia; Animals; Body Temperature; Hypophysectomy; Male; Methadone; Morphine; Narcotics; Rats; Rats, Inbred Strains; Stress, Physiological | 1984 |
Methadone induced physical dependence in the rat.
Topics: Animals; Behavior, Animal; Body Weight; Escape Reaction; Humans; Male; Methadone; Morphine; Motor Activity; Naloxone; Rats; Rats, Inbred Strains; Self Stimulation; Substance-Related Disorders; Tremor | 1984 |
Differential effects of opiate peptides and alkaloids on anterior pituitary hormone secretion.
Topics: Adult; Alkaloids; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Drug Antagonism; Growth Hormone; Humans; Male; Methadone; Morphine; Nalorphine; Narcotics; Pentazocine; Pituitary Hormones, Anterior; Prolactin; Thyrotropin | 1983 |
Endocrine effects of methadone in rats; acute effects in adults.
Topics: Aging; Animals; Corticosterone; Dose-Response Relationship, Drug; Female; Growth Hormone; Hormones; Male; Methadone; Morphine; Naloxone; Prolactin; Rats; Rats, Inbred Strains; Sex Factors; Thyrotropin | 1983 |
Effects of opiates on fetal behavioral activity in utero.
Topics: Animals; Blood Pressure; Female; Fetal Heart; Fetus; Heart Rate; Maternal-Fetal Exchange; Methadone; Morphine; Pregnancy; Sheep | 1983 |
Overall evaluation of treatment modalities for heroin addiction in a toxicology unit.
Topics: Clonidine; Heroin Dependence; Hospital Units; Humans; Methadone; Morphine; Naloxone; Narcotics; Outcome and Process Assessment, Health Care; Patient Dropouts; Substance Withdrawal Syndrome | 1983 |
Withdrawal tolerance and unidirectional non-cross-tolerance in narcotic pellet-implanted mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Etorphine; Heroin; Humans; Male; Methadone; Mice; Morphine; Narcotics; Opioid-Related Disorders; Solubility; Substance Withdrawal Syndrome | 1983 |
Substance abuse research in monkey social groups.
Topics: Animals; Humans; Macaca nemestrina; Macaca radiata; Male; Methadone; Methamphetamine; Morphine; Motor Activity; Pentobarbital; Sexual Behavior, Animal; Social Behavior; Substance-Related Disorders | 1983 |
A novel form of dependency of hepatic extraction ratio of opioids in vivo upon the portal vein concentration of drug: comparison of morphine, diamorphine, fentanyl, methadone and buprenorphine in the chronically cannulated cow.
Topics: Animals; Buprenorphine; Cattle; Female; Fentanyl; Heroin; Kinetics; Liver; Liver Circulation; Methadone; Morphinans; Morphine; Narcotics | 1984 |
Modification of drug effects by l-alpha-acetylmethadol.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Methadone; Methadyl Acetate; Morphine; Pentobarbital; Phencyclidine; Rats; Rats, Inbred Strains | 1984 |
Comparative study of postmortem barbiturates, methadone, and morphine in vitreous humor, blood, and tissue.
Topics: Autopsy; Barbiturates; Blood Chemical Analysis; Humans; Methadone; Morphine; Radioimmunoassay; Tissue Distribution; Vitreous Body | 1984 |
Annual report: biological evaluation of compounds for their dependence liability. IV. Drug testing program of the Committee on Problems of Drug, Dependence, Inc. (1980).
Topics: Analgesics; Animals; Benzomorphans; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Drug Evaluation; Guinea Pigs; Humans; Meperidine; Methadone; Morphinans; Morphine; National Institutes of Health (U.S.); Rats; Research Support as Topic; Spectrophotometry, Infrared; Substance-Related Disorders; United States | 1981 |
Effects of levo-alpha-acetylmethadol (LAAM) on morphine self-administration in the rat.
Topics: Animals; Electroencephalography; Female; Methadone; Methadyl Acetate; Morphine; Rats; Self Administration; Sleep, REM | 1981 |
Effects of selected opioid agonists and antagonists on DMT- and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat.
Topics: Animals; Conditioning, Operant; Drug Interactions; Drug Synergism; Lysergic Acid Diethylamide; Male; Methadone; Morphine; N,N-Dimethyltryptamine; Naloxone; Naltrexone; Narcotics; Rats; Reinforcement, Psychology; Tryptamines | 1981 |
Direct relationship of brain concentration of methadone with analgesia in chronic morphine-implanted and acute naloxone-treated rats.
Topics: Analgesia; Animals; Brain; Methadone; Morphine; Naloxone; Rats | 1982 |
Cimetidine potentiation of narcotic action.
Topics: Adenocarcinoma; Aged; Cimetidine; Drug Synergism; Guanidines; Humans; Lung Neoplasms; Male; Methadone; Morphine; Narcotics; Pain | 1983 |
Attenuation of the behavioral effects of meperidine and normeperidine by daily administration of diazepam.
Topics: Animals; Columbidae; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Male; Meperidine; Methadone; Morphine; Pentobarbital | 1983 |
Antitussive effect of the optical isomers of mu, kappa and sigma opiate agonists/antagonists in the cat.
Topics: Animals; Antitussive Agents; Blood Pressure; Cats; Codeine; Cyclazocine; Dextromethorphan; Female; Heart Rate; Male; Methadone; Morphine; Narcotics; Phenazocine; Stereoisomerism | 1983 |
Behavioral effects of the optical isomers of methadone in the rat during acute and chronic administration.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Isomerism; Male; Methadone; Morphine; Motor Activity; Optical Rotation; Rats | 1983 |
The effect of morphine, methadone, and naloxone on taurine transport in human blood platelets.
Topics: Biological Transport, Active; Blood Platelets; Humans; Kinetics; Methadone; Morphine; Naloxone; Sodium; Spectrophotometry; Taurine | 1983 |
[Morphine and methadone in severe cancer pain--new pharmacokinetic bases for optimal therapy].
Topics: Chronic Disease; Humans; Kinetics; Methadone; Morphine; Neoplasms; Pain | 1983 |
Effect of morphine and morphine-like drugs on carbachol-induced fighting in cats.
Topics: Aggression; Agonistic Behavior; Animals; Carbachol; Cats; Female; Humans; Injections, Intraventricular; Male; Meperidine; Methadone; Morphine | 1982 |
Clinical evaluation of combined treatment with methadone and psychotropic drugs in cancer patients.
Topics: Adult; Aged; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable; Psychotropic Drugs; Time Factors | 1982 |
Metabolic studies with an isolated, perfused rat brain preparation.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain; Dimethyl Sulfoxide; Energy Metabolism; Ethanol; Insulin; Methadone; Morphine; Perfusion; Rats | 1982 |
Effects of parenteral morphine and oral methadone on self-stimulation in the rat.
Topics: Administration, Oral; Animals; Electric Stimulation; Injections, Intraperitoneal; Male; Methadone; Morphine; Rats; Rats, Inbred Strains; Self Stimulation | 1982 |
The effects of morphine on calcium-regulated phosphorylation of synaptosomal cytosolic proteins from rat striatum.
Topics: Animals; Calcium; Corpus Striatum; Cytosol; In Vitro Techniques; Levorphanol; Male; Methadone; Morphine; Naloxone; Nerve Tissue Proteins; Phosphorylation; Rats; Stereoisomerism; Synaptosomes | 1982 |
Oral methadone for relief of chronic pain from cancer.
Topics: Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain, Intractable | 1982 |
A comparison of morphine and methadone disposition in the maternal-fetal unit.
Topics: Animals; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Metabolic Clearance Rate; Methadone; Morphine; Placenta; Pregnancy; Protein Binding; Sheep | 1982 |
The antinociceptive effects of epidural opiates in the cat: studies of the pharmacology and the effects of lipophilicity in spinal analgesia.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Epidural Space; Female; Fentanyl; Lipids; Male; Meperidine; Methadone; Morphine; Naloxone; Narcotics; Nociceptors; Pain; Reflex; Skin; Time Factors | 1982 |
Morphine- and methadone-tolerant mice differ in cross-tolerance to other opiates. Heterogeneity in opioid mechanisms indicated.
Topics: Analgesia; Animals; Body Weight; Drug Tolerance; Male; Methadone; Mice; Morphine; Narcotics; Reaction Time | 1982 |
Motility response of rats to chronic constant-dose treatment with narcotics.
Topics: Animals; Male; Meperidine; Methadone; Morphine; Motor Activity; Narcotics; Pentazocine; Rats; Rats, Inbred Strains; Time Factors | 1982 |
The role of calmodulin in opioid-induced changes in the phosphorylation of rat striatal synaptic membrane proteins.
Topics: Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Corpus Striatum; Etorphine; Kinetics; Male; Membrane Proteins; Methadone; Morphinans; Morphine; Phosphorylation; Protein Kinases; Rats; Synaptic Membranes; Synaptosomes | 1982 |
Tolerance to methadone lethality and microsomal enzyme induction in mice tolerant to and dependent on morphine.
Topics: Animals; Body Weight; Drug Tolerance; Enzyme Induction; Humans; Inactivation, Metabolic; Lethal Dose 50; Liver; Male; Methadone; Mice; Microsomes, Liver; Morphine; Morphine Dependence; Oxidoreductases, N-Demethylating; Proadifen | 1980 |
Narcotic abstinence in dependent rats: EEG and behavioral correlates.
Topics: Animals; Behavior, Animal; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Sleep, REM; Substance Withdrawal Syndrome | 1980 |
A method for determining cumulative behavioral toxicity after chronic oral administration of l-alpha-acetylmethadol to female rats.
Topics: Administration, Oral; Animals; Behavior, Animal; Drug Tolerance; Female; Fetus; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Substance-Related Disorders | 1980 |
Morphine challenges in levo-alpha-acetylmethadol (LAAM) post-addict rats.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Wakefulness | 1981 |
Differential electroencephalographic and behavioral cross tolerance to morphine and methadone in the l-alpha-acetylmethadol (LAAM)-maintained rat.
Topics: Animals; Behavior, Animal; Drug Tolerance; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Rats, Inbred Strains | 1982 |
Reducing drug use among methadone maintenance clients: contingent reinforcement for morphine-free urines.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Morphine; Reinforcement, Psychology; Substance-Related Disorders | 1980 |
Effects of pentazocine and nalorphine of motility in chronically morphine treated rats: a potential substitution test to detect the narcotic character of a drug.
Topics: Animals; Drug Evaluation, Preclinical; Male; Methadone; Morphine; Motor Activity; Nalorphine; Narcotics; Pentazocine; Rats; Time Factors | 1981 |
Inhibition by morphine and morphine-like drugs of nicotine-induced emesis in cats.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Emetics; Female; Injections, Intraventricular; Male; Meperidine; Methadone; Morphine; Nicotine; Vomiting | 1981 |
Protein concentration effects on binding of 14C-codeine, 14C-morphine, and 3H-methadone to human serum albumin.
Topics: Carbon Radioisotopes; Codeine; Humans; Methadone; Morphine; Protein Binding; Serum Albumin; Tritium | 1980 |
Effects of morphine and methadone on the isolated perfused rat brain.
Topics: Animals; Brain; Electroencephalography; Glucose; In Vitro Techniques; Lactates; Male; Methadone; Morphine; Rats | 1980 |
Comparative study of the electroencephalographic and behavioral effects of l-alpha-acetylmethadol (LAAM), two of its metabolites and morphine and methadone in the rat.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electrocardiography; Female; Methadone; Methadyl Acetate; Morphine; Rats | 1980 |
Effects of drugs on behavior in rats maintained on morphine, methadone or pentobarbital.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Drug Administration Schedule; Drug Interactions; Male; Methadone; Morphine; Pentobarbital; Rats | 1980 |
From IM morphine to PO methadone.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Morphine; Substance Withdrawal Syndrome | 1980 |
Dantrolene treatment of opioid-induced myoclonus.
Topics: Aged; Analgesics, Opioid; Dantrolene; Humans; Male; Methadone; Middle Aged; Morphine; Muscle Relaxants, Central; Myoclonus; Pain; Palliative Care | 1995 |
Successful use of methadone in nociceptive cancer pain unresponsive to morphine.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain Measurement; Pain, Intractable; Palliative Care | 1994 |
Activation of xenobiotics into free radicals by prostaglandin-H-synthase and by rat liver microsomes.
Topics: Animals; Cocaine; Free Radicals; Histamine Release; Malondialdehyde; Mast Cells; Methadone; Microsomes, Liver; Morphine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Xenobiotics | 1995 |
The 'glibenclamide-shift' of centrally-acting antinociceptive agents in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glyburide; Male; Methadone; Mice; Mice, Inbred ICR; Morphine; Potassium Channels | 1995 |
The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine.
Topics: Animals; Binding, Competitive; Cattle; Methadone; Morphine; Protein Binding; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reproducibility of Results; Stereoisomerism | 1995 |
Opioids induce while nicotine suppresses apoptosis in human lung cancer cells.
Topics: Apoptosis; DNA Damage; DNA, Neoplasm; Drug Synergism; Hexamethonium; Humans; Lung Neoplasms; Methadone; Morphine; Nicotine; Receptors, Cholinergic; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
[Value and limitations of substitution treatments in the care of drug addicts].
Topics: Acquired Immunodeficiency Syndrome; Adult; Buprenorphine; France; HIV Infections; HIV Seropositivity; Humans; Mental Disorders; Methadone; Morphine; Paris; Substance-Related Disorders; Time Factors | 1994 |
[How to treat a patient with AIDS and drug dependence unwilling and/or unable to withdraw? Give substitution drugs at the hospital? Should substitution be continued after discharge? Is substitution a useful adjuvant to programs designed to prevent opportu
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Buprenorphine; Emergencies; Heroin Dependence; HIV Infections; Hospitalization; Humans; Methadone; Morphine; Outpatients; Patient Care Team; Substance-Related Disorders | 1994 |
Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists.
Topics: Adult; Aged; Analgesics, Opioid; Child; Delayed-Action Preparations; Female; Humans; Hyperalgesia; Male; Meperidine; Methadone; Middle Aged; Morphine; Myoclonus; Narcotics; Neoplasms; Pain; Sufentanil | 1994 |
Methadone in pain uncontrolled by morphine.
Topics: Adult; Female; Humans; Methadone; Morphine; Pain | 1993 |
[Diversified prescription of narcotics to heroin addicts. Basis, design, research plan].
Topics: Clinical Trials as Topic; Cocaine; Drug Prescriptions; Female; Heroin; Humans; Male; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Pilot Projects; Program Evaluation; Research Design | 1994 |
Deaths among drug addicts in Denmark in 1987-1991.
Topics: Adolescent; Adult; Alcoholism; Amphetamine; Analgesics, Opioid; Barbiturates; Cannabis; Cause of Death; Denmark; Dextropropoxyphene; Female; Heroin; Humans; Male; Meperidine; Methadone; Morphine; Substance-Related Disorders; Suicide; Survival Rate | 1994 |
Effect of morphine and methadone acute treatment on immunological activity in mice: pharmacokinetic and pharmacodynamic correlates.
Topics: Animals; Cytotoxicity, Immunologic; Immunity; Killer Cells, Natural; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Neutrophils; Respiratory Burst | 1994 |
The effects of exercise on the oral consumption of morphine and methadone in rats.
Topics: Administration, Oral; Animals; beta-Endorphin; Body Weight; Brain Chemistry; Drinking; Male; Methadone; Morphine; Physical Exertion; Rats | 1994 |
Simultaneous determination of drugs of abuse (opiates, cocaine and amphetamine) in human hair by GC/MS and its application to a methadone treatment program.
Topics: Adult; Amphetamine; Calibration; Cocaine; Codeine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Illicit Drugs; Male; Methadone; Morphine; Morphine Derivatives; Reproducibility of Results; Substance Abuse Detection; Substance-Related Disorders | 1993 |
CSF neuropeptides in cancer pain: effects of spinal opioid therapy.
Topics: Aged; Bupivacaine; Female; Humans; Injections, Epidural; Injections, Spinal; Male; Methadone; Middle Aged; Morphine; Neoplasms; Neuropeptides; Pain | 1993 |
Macrophage functions in drugs of abuse-treated mice.
Topics: Animals; Cell Division; Cells, Cultured; Cocaine; Interleukin-1; Leukemia L1210; Macrophages, Peritoneal; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Legal opioid consumption in Denmark 1981-1993.
Topics: Analgesia; Analgesics, Opioid; Buprenorphine; Denmark; Humans; Legislation, Drug; Meperidine; Methadone; Morphine | 1995 |
Free radical mediated release of histamine from rat mast cells induced by drugs of abuse.
Topics: Animals; Cocaine; Cyclic N-Oxides; Dose-Response Relationship, Drug; Fluorometry; Free Radical Scavengers; Free Radicals; Glutathione; Histamine Release; Illicit Drugs; L-Lactate Dehydrogenase; Malondialdehyde; Mast Cells; Methadone; Morphine; Narcotics; Peritoneal Cavity; Pleura; Rats; Rats, Wistar; Spectrophotometry; Vitamin E | 1996 |
Influence of plasma-protein binding on analgesic effect of methadone in rats with spontaneous withdrawal.
Topics: Analgesics, Opioid; Animals; Male; Methadone; Morphine; Narcotics; Orosomucoid; Pain Measurement; Protein Binding; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1996 |
Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hydromorphone; Injections, Subcutaneous; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Retrospective Studies | 1996 |
Fatal poisonings in young drug addicts in the Nordic countries: a comparison between 1984-1985 and 1991.
Topics: Adolescent; Adult; Age Distribution; Finland; Heroin; Humans; Iceland; Methadone; Morphine; Narcotics; Scandinavian and Nordic Countries; Substance-Related Disorders | 1996 |
Changes in opioid receptor density on murine splenocytes induced by in vivo treatment with morphine and methadone.
Topics: Analgesics, Opioid; Animals; Lymphocytes; Macrophages; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Receptors, Opioid; Spleen | 1996 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
[Initial results with withdrawal treatments of male and female participants in the diversified Janus opiate prescription project in Basel].
Topics: Adult; Female; Heroin; Humans; Injections, Intravenous; Male; Methadone; Morphine; Substance Abuse Treatment Centers; Substance-Related Disorders; Treatment Outcome | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
[Pregnancy and drug dependence].
Topics: Administration, Oral; Adult; Austria; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Patient Care Team; Pregnancy; Pregnancy Complications | 1996 |
International opioid consumption.
Topics: Analgesics, Opioid; Denmark; Drug Utilization; Humans; Meperidine; Methadone; Morphine; Pain | 1997 |
Pharmacologic treatment of cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Therapeutic Equivalency | 1997 |
Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Hydromorphone; Injections, Intravenous; Male; Methadone; Morphine; Pain; Palliative Care; Peritoneal Neoplasms; Retreatment; Stomach Neoplasms | 1997 |
Modulation of immunoreactive protein kinase C-alpha and beta isoforms and G proteins by acute and chronic treatments with morphine and other opiate drugs in rat brain.
Topics: Animals; Brain; Dose-Response Relationship, Drug; GTP-Binding Proteins; Immunohistochemistry; Male; Methadone; Morphine; Narcotics; Protein Kinase C; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
[Pupillary diameter and pupillary reactions in heroin dependent patients and in patients participating in a methadone and morphine replacement program].
Topics: Adult; Delayed-Action Preparations; Female; Heroin Dependence; Humans; Male; Methadone; Morphine; Narcotics; Pupil Disorders; Reflex, Pupillary; Signal Processing, Computer-Assisted | 1997 |
Discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), buprenorphine and methadone in morphine-treated rhesus monkeys.
Topics: Animals; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
Effect of acute and chronic tramadol on [3H]-5-HT uptake in rat cortical synaptosomes.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cerebral Cortex; Male; Methadone; Morphine; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin; Synaptosomes; Tramadol | 1997 |
Atypical urinary opiate excretion pattern.
Topics: Adult; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Reference Standards; Twins | 1997 |
[Pain, anesthesia and drug addiction].
Topics: Anesthesia; Comprehensive Health Care; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Narcotics; Pain; Physician-Patient Relations; Substance Abuse Treatment Centers; Substance-Related Disorders | 1997 |
l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog.
Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1997 |
[Changes in the pattern of opioid analgesic consumption in Spain].
Topics: Administration, Oral; Administration, Rectal; Analgesics, Opioid; Buprenorphine; Codeine; Databases as Topic; Dextropropoxyphene; Drug Prescriptions; Humans; Injections, Intravenous; Linear Models; Meperidine; Methadone; Morphine; Pentazocine; Spain; Tilidine; Tramadol | 1997 |
Intravenous high-dose methadone administered by patient controlled analgesia and continuous infusion for the treatment of cancer pain refractory to high-dose morphine.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Treatment Outcome | 1997 |
Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts.
Topics: Adolescent; Adult; Animals; beta-Adrenergic Receptor Kinases; Brain; Cyclic AMP-Dependent Protein Kinases; Female; G-Protein-Coupled Receptor Kinase 2; Humans; Male; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1998 |
Use of methadone in the morphine-tolerant burned paediatric patient.
Topics: Analgesics, Opioid; Burns; Child; Conscious Sedation; Critical Care; Drug Tolerance; Female; Humans; Infant; Methadone; Morphine; Respiration, Artificial | 1998 |
Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Retrospective Studies | 1998 |
Opioid responsive central pain of cerebrovascular origin: a case report.
Topics: Analgesics, Opioid; Cerebrovascular Disorders; Humans; Male; Methadone; Middle Aged; Morphine; Pain, Intractable; Palliative Care | 1997 |
Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals.
Topics: Animals; Biotransformation; Cell Separation; Cocaine; Dopamine Uptake Inhibitors; Enzyme Induction; Free Radical Scavengers; Free Radicals; Histamine Release; Illicit Drugs; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Malondialdehyde; Mast Cells; Methadone; Microsomes, Liver; Morphine; Narcotics; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar | 1998 |
Opioid receptor agonists and antagonists alter GBR12909-induced turning in the rat.
Topics: Animals; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1998 |
A method for the confirmation and identification of drugs of misuse in urine using solid phase extraction and gas-liquid chromatography with mass spectrometry.
Topics: Codeine; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Methadone; Morphine; Morphine Derivatives; Sensitivity and Specificity; Substance Abuse Detection | 1998 |
Methadone analgesia in morphine-insensitive CXBK mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Drug Resistance; Male; Methadone; Mice; Morphine | 1998 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Aspirin; Constipation; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Tolerance; Half-Life; Humans; Injections, Intramuscular; Injections, Intravenous; Ketorolac; Levorphanol; Meperidine; Methadone; Morphine; Narcotic Antagonists; Narcotics; Pain; Tolmetin; Tramadol | 1998 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
Comment on Manfredi et al.,Pain, 70 (1997) 199-101.
Topics: Analgesics, Opioid; Humans; Hydromorphone; Injections, Intravenous; Methadone; Morphine; Neoplasms; Palliative Care; Retreatment | 1998 |
Effects of prolonged exposure to morphine and methadone on in vivo parameters of immune function in rats.
Topics: Animals; Immunity; Immunoglobulins; Listeria monocytogenes; Male; Methadone; Morphine; Narcotics; Rats; Rats, Wistar; Trichinella spiralis | 1998 |
Methadone in cancer pain management: individualize dose and titrate to effect.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain Management | 1998 |
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Prospective Studies; Therapeutic Equivalency; Time Factors | 1998 |
The mu opioid irreversible antagonist beta-funaltrexamine differentiates the discriminative stimulus effects of opioids with high and low efficacy at the mu opioid receptor.
Topics: Animals; Buprenorphine; Butorphanol; Columbidae; Discrimination Learning; Female; Fentanyl; Levallorphan; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 1998 |
Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats.
Topics: Analgesics, Opioid; Animals; Brain; Male; Methadone; Morphine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1999 |
Opioid substitution to reduce adverse effects in cancer pain management.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical Audit; Methadone; Middle Aged; Morphine; Nausea; Neoplasms; Oxycodone; Pain; Pain Measurement; Prospective Studies; Sleep Stages; Sufentanil; Vomiting | 1999 |
Opioids accelerate fetal rat lung maturation in vitro.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Heroin; In Vitro Techniques; Lung; Methadone; Morphine; Narcotics; Rats; Rats, Sprague-Dawley | 1999 |
Effect of electrolyte and solvent composition on capillary electrophoretic separation of some pharmaceuticals in non-aqueous media.
Topics: Acetates; Acetonitriles; Ammonium Chloride; Bromides; Dextromoramide; Dose-Response Relationship, Drug; Electrolytes; Electrophoresis, Capillary; Ephedrine; Hydrogen-Ion Concentration; Levorphanol; Lithium Compounds; Methadone; Methanol; Morphine; Potassium Acetate; Quaternary Ammonium Compounds; Sodium Acetate; Time Factors; Viscosity | 1999 |
Harm reduction in Bern: from outreach to heroin maintenance.
Topics: Drug and Narcotic Control; Drug Prescriptions; Health Policy; Heroin; Humans; Methadone; Morphine; Narcotics; Substance Abuse, Intravenous; Substance-Related Disorders; Switzerland | 1995 |
d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Hyperalgesia; Injections, Spinal; Male; Methadone; Mice; Morphine; N-Methylaspartate; Pain Measurement; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1999 |
The difference between methadone and morphine in regulation of delta-opioid receptors underlies the antagonistic effect of methadone on morphine-mediated cellular actions.
Topics: Adenylyl Cyclases; Alkaloids; Analgesics, Opioid; Animals; Benzophenanthridines; Colforsin; Cyclic AMP; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Hybrid Cells; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Phenanthridines; Protein Kinase C; Rats; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 1999 |
Nalorphine's ability to substitute for morphine in a drug discrimination procedure is a function of training dose.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Female; Generalization, Response; Methadone; Morphine; Nalorphine; Narcotic Antagonists; Narcotics; Rats; Rats, Long-Evans | 1999 |
Methadone-induced desensitization of the delta-opioid receptor is mediated by uncoupling of receptor from G protein.
Topics: Animals; CHO Cells; Cricetinae; Cyclic AMP; Down-Regulation; Drug Interactions; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Methadone; Morphine; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 1999 |
Drug abuse-related mortality: a study of teenage addicts over a 20-year period.
Topics: Adolescent; Adult; Age Distribution; Behavior, Addictive; England; Female; Heroin; Humans; Longitudinal Studies; Male; Methadone; Morphine; Mortality; Narcotics; Sex Distribution; Substance-Related Disorders; Suicide; Wales | 1999 |
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Patient Satisfaction; Prospective Studies | 1999 |
Reduction in constipation and laxative requirements following opioid rotation to methadone: a report of four cases.
Topics: Analgesics, Opioid; Cathartics; Constipation; Female; Humans; Methadone; Middle Aged; Morphine | 1999 |
The dual modulation of GIRK1/GIRK2 channels by opioid receptor ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextropropoxyphene; DNA, Recombinant; Dose-Response Relationship, Drug; Electric Stimulation; Female; GTP-Binding Proteins; Ligands; Membrane Potentials; Methadone; Mice; Microinjections; Morphine; Naloxone; Oocytes; Patch-Clamp Techniques; Plasmids; Potassium Channels; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Complementary; Xenopus laevis | 1999 |
Opioid consumption in Spain--the significance of a regulatory measure.
Topics: Analgesics, Opioid; Drug and Narcotic Control; Drug Utilization; Fentanyl; Humans; Meperidine; Methadone; Morphine; Regression Analysis; Spain; Tilidine | 1999 |
Discriminative stimulus effects of two doses of fentanyl in rats: pharmacological selectivity and effect of training dose on agonist and antagonist effects of mu opioids.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Fentanyl; Male; Methadone; Morphine; Nalbuphine; Nalorphine; Naltrexone; Narcotic Antagonists; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2000 |
Effects of opioid receptor agonists on cAMP second messenger system.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Buprenorphine; Cyclic AMP; Etorphine; Glioma; Humans; Hybrid Cells; Methadone; Morphine; Neuroblastoma; Opioid-Related Disorders; Receptors, Opioid; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Effects of low-pH treatment on cAMP second messenger system regulated by different opioid agonists.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Buprenorphine; Cyclic AMP; Etorphine; Glioma; Humans; Hybrid Cells; Hydrogen-Ion Concentration; Methadone; Morphine; Neuroblastoma; Opioid-Related Disorders; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Morphine and methadone have different effects on calcium channel currents in neuroblastoma cells.
Topics: Animals; Calcium Channels; Membrane Potentials; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Neurons; Patch-Clamp Techniques; Tumor Cells, Cultured | 2000 |
The merits of methadone.
Topics: Adult; Analgesics, Opioid; Child; Child, Preschool; Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain | 2000 |
Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism.
Topics: Animals; Benzamides; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Response; Methadone; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Piperazines; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Modified liquid junction interface for nonaqueous capillary electrophoresis-mass spectrometry.
Topics: Codeine; Electrophoresis, Capillary; Equipment Design; Indicators and Reagents; Levorphanol; Methadone; Morphine; Pentazocine; Pharmaceutical Preparations; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2000 |
[Fatal intoxications among drug addicts in Denmark in 1997].
Topics: Adolescent; Adult; Analgesics, Opioid; Cause of Death; Denmark; Drug Overdose; Female; Forensic Medicine; Heroin; Humans; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Substance-Related Disorders | 2000 |
Comparison of [(3)H]Glyburide binding with opiate analgesia, tolerance, and dependence in ICR and Swiss-Webster mice.
Topics: Analgesics, Opioid; Animals; ATP-Binding Cassette Transporters; Drug Tolerance; Glyburide; Male; Methadone; Mice; Morphine; Motor Activity; Opioid-Related Disorders; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Species Specificity; Sulfonylurea Receptors; Time Factors | 2000 |
[Opioids. Pharmacology, clinic, prospectives for an extensive use].
Topics: Analgesics, Opioid; Codeine; Drug Tolerance; Fentanyl; Humans; Hydromorphone; Methadone; Morphine; Oxycodone; Receptors, Opioid; Tramadol | 2000 |
Trends in licit opioid use in Australia, 1984-1998: comparative analysis of international and jurisdictional data.
Topics: Australia; Developed Countries; Drug Utilization; Humans; Meperidine; Methadone; Morphine; Narcotics; Opioid-Related Disorders; Practice Patterns, Physicians' | 2000 |
Morphine and alternative opioids in cancer pain: the EAPC recommendations.
Topics: Administration, Oral; Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Administration Schedule; Fentanyl; Humans; Hydromorphone; Infusions, Intravenous; Injections, Spinal; Injections, Subcutaneous; Methadone; Morphine; Neoplasms; Oxycodone; Pain; Palliative Care | 2001 |
Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia.
Topics: Analgesics, Opioid; Animals; Buprenorphine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heroin; Heterotrimeric GTP-Binding Proteins; Lateral Ventricles; Male; Methadone; Mice; Morphine; Pain Measurement; Receptors, Opioid, mu | 2001 |
Methadone in treatment of tenesmus not responding to morphine escalation.
Topics: Aged; Analgesics, Opioid; Anus Diseases; Defecation; Humans; Male; Methadone; Morphine; Pain; Rectal Neoplasms; Sensation Disorders | 2001 |
Determination of opiates in serum, saliva and hair addicted persons.
Topics: Adult; Codeine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Hydrogen-Ion Concentration; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Opioid-Related Disorders; Saliva | 2001 |
Drug related deaths in the Strathclyde region of Scotland, 1995-1998.
Topics: Adolescent; Adult; Cause of Death; Diazepam; Female; Humans; Incidence; Male; Methadone; Middle Aged; Morphine; Prisoners; Scotland; Substance-Related Disorders; Temazepam | 2001 |
Detection of opiate use in a methadone maintenance treatment population with the CEDIA 6-acetylmorphine and CEDIA DAU opiate assays.
Topics: Adolescent; Adult; Cocaine-Related Disorders; Codeine; False Positive Reactions; Female; Gas Chromatography-Mass Spectrometry; Heroin Dependence; Humans; Immunoenzyme Techniques; Male; Methadone; Middle Aged; Morphine; Morphine Derivatives; Narcotics; Sensitivity and Specificity; Substance Abuse Detection; Workplace | 2001 |
Opioid therapy for chronic painful conditions.
Topics: Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Karnofsky Performance Status; Low Back Pain; Methadone; Morphine; Opioid-Related Disorders; Oxycodone; Pain; Patient Selection; Practice Guidelines as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Time Factors | 2001 |
Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.
Topics: Analgesics, Opioid; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Drug Tolerance; Endocytosis; Humans; Methadone; Morphine; Mutation; Narcotics; Protein Transport; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2001 |
Methadone enhances human immunodeficiency virus infection of human immune cells.
Topics: Adult; Drug Interactions; Fetus; HIV Infections; Humans; Immunosuppressive Agents; Macrophages; Methadone; Microglia; Middle Aged; Monocytes; Morphine; Naltrexone; Narcotics; Receptors, CCR5 | 2002 |
HIV and hepatitis virus infections among injecting drug users in a medically controlled heroin prescription programme.
Topics: Adult; Drug Prescriptions; Female; Health Policy; Hepatitis B; Hepatitis C; Heroin; HIV Infections; Humans; Incidence; Male; Methadone; Morphine; Prevalence; Public Health Practice; Substance Abuse, Intravenous; Switzerland | 2001 |
Patient-controlled analgesia with intravenous L-methadone in a child with cancer pain refractory to high-dose morphine.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Child; Humans; Infusions, Intravenous; Male; Methadone; Morphine; Neoplasms; Pain, Intractable; Treatment Failure | 2002 |
Reduced tolerance to the anti-hyperalgesic effect of methadone in comparison to morphine in a rat model of mononeuropathy.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male; Methadone; Mononeuropathies; Morphine; Rats; Rats, Sprague-Dawley | 2002 |
Neurologic complications including paralysis after a medication error involving implanted intrathecal catheters.
Topics: Adult; Aged; Analgesics, Opioid; Catheters, Indwelling; Cluster Analysis; Cohort Studies; Disease Outbreaks; Drug Compounding; Drug Contamination; Epidural Abscess; Ethanol; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Medication Errors; Methadone; Methanol; Middle Aged; Morphine; Pain; Paralysis; Pharmacy; Risk Factors; Tennessee | 2002 |
Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis.
Topics: Adenocarcinoma; Adult; Analgesics, Opioid; Fibrosis; Half-Life; Humans; Lung Neoplasms; Male; Metabolic Clearance Rate; Methadone; Morphine; Opioid-Related Disorders; Pain | 2001 |
[Opioid treatment of pain in angina pectoris].
Topics: Aged; Analgesics, Opioid; Angina, Unstable; Humans; Male; Methadone; Morphine; Substance Withdrawal Syndrome | 2002 |
Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan.
Topics: Analgesics, Opioid; Animals; Catalepsy; Central Nervous System; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Methadone; Morphine; Neurons; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 2002 |
Successful use of oral methadone after failure of intravenous morphine and ketamine.
Topics: Acute Disease; Administration, Oral; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Drug Tolerance; Humans; Ketamine; Male; Methadone; Morphine; Opioid-Related Disorders; Pain; Substance Abuse, Intravenous | 2002 |
Synergy between mu opioid ligands: evidence for functional interactions among mu opioid receptor subtypes.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Gastrointestinal Transit; Ligands; Male; Methadone; Mice; Morphine; Pain Measurement; Receptors, Opioid, mu | 2002 |
Methadone, morphine and PTSD.
Topics: Adult; Analgesics, Opioid; Female; Humans; Methadone; Morphine; Stress Disorders, Post-Traumatic; Substance-Related Disorders | 2002 |
Flunitrazepam variably alters morphine, buprenorphine, and methadone lethality in the rat.
Topics: Animals; Anti-Anxiety Agents; Buprenorphine; Drug Interactions; Flunitrazepam; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Male; Methadone; Morphine; Narcotics; Rats; Rats, Sprague-Dawley | 2002 |
[Clinial study of "qingjunyin" detoxification for the treatment of heroin addicts].
Topics: Adolescent; Adult; Clonidine; Drug Combinations; Drug Evaluation; Drugs, Chinese Herbal; Female; Heroin Dependence; Humans; Male; Methadone; Morphine; Phytotherapy | 1997 |
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Substance-Related Disorders | 2003 |
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Pentazocine; Pituitary Neoplasms; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured | 2003 |
Use of irreversible antagonists to determine the relative efficacy of mu-opioids in a pigeon drug discrimination procedure: comparison of beta-funaltrexamine and clocinnamox.
Topics: Animals; Cinnamates; Columbidae; Female; Fentanyl; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Reaction Time; Receptors, Opioid, mu; Sufentanil | 2003 |
Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial.
Topics: Analgesics, Opioid; Herpes Zoster; Humans; Methadone; Morphine; Neuralgia; Neurotransmitter Uptake Inhibitors; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Reproducibility of Results | 2003 |
[Electrodermal activity in heroin addicts and patients with methadone and morphine substitution].
Topics: Adult; Arousal; Austria; Delayed-Action Preparations; Female; Galvanic Skin Response; Habituation, Psychophysiologic; Heroin Dependence; Humans; Male; Methadone; Morphine; Reaction Time; Reference Values; Rehabilitation Centers; Sympathetic Nervous System | 2003 |
Opioid plasma concentration during switching from morphine to methadone: preliminary data.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable; Prospective Studies; Time Factors; Treatment Outcome | 2003 |
An ad libitum schedule for conversion of morphine to methadone in advanced cancer patients: an open uncontrolled prospective study in a Chinese population.
Topics: Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; China; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Prospective Studies | 2003 |
Methadone and its role in drug-related fatalities in Cologne 1989-2000.
Topics: Benzodiazepines; Cause of Death; Drug Overdose; Ethanol; Female; Germany; Heroin; Humans; Illicit Drugs; Male; Methadone; Morphine; Narcotics; Substance-Related Disorders | 2003 |
Strabismus in infants of opiate-dependent mothers.
Topics: Australia; Codeine; Cross-Sectional Studies; Female; Heroin; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal Exchange; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Neonatal Screening; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Prevalence; Severity of Illness Index; Strabismus | 2003 |
Methadone substitution: medicolegal problems in Germany.
Topics: Adolescent; Adult; Amphetamines; Antidepressive Agents; Automobile Driving; Benzodiazepines; Cannabinoids; Cocaine; Drug and Narcotic Control; Ethanol; Female; Forensic Medicine; Germany; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; Practice Patterns, Physicians'; Substance-Related Disorders | 2003 |
Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.
Topics: Animals; Dendrites; Endocytosis; Genetic Vectors; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Membrane Proteins; Methadone; Morphine; Mutation; Neurons; Nucleus Accumbens; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Proteins; Simplexvirus | 2003 |
Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice.
Topics: Animals; Area Under Curve; Behavior, Animal; Cell Membrane; Dose-Response Relationship, Drug; Drug Administration Schedule; Etorphine; Female; Fentanyl; Male; Methadone; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotics; Pain Measurement; Posterior Horn Cells; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Time; Up-Regulation | 2003 |
Psychoactive drugs and quality of life.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amphetamines; Cocaine; Cohort Studies; Data Collection; Hallucinogens; Heroin; Humans; Marijuana Abuse; Methadone; Middle Aged; Morphine; Psychotropic Drugs; Quality of Life; Stimulants, Historical; Substance-Related Disorders; Surveys and Questionnaires | 2003 |
Action of analgesic drugs morphine, meperidine, methadone on rotatory nystagmus in the rabbit.
Topics: Analgesics; Animals; Meperidine; Methadone; Morphine; Nystagmus, Pathologic; Rabbits | 1953 |
[Microscopical detection of morphine-like compounds].
Topics: Analgesics; Meperidine; Methadone; Morphine | 1953 |
Analgesics and enzymes of the cytochrome chain.
Topics: Analgesics; Brain; Cytochromes; Meperidine; Methadone; Morphine; Myocardium; Oxidoreductases | 1953 |
[Experiences with polamidon C].
Topics: Methadone; Morphine | 1953 |
N-Allylnormorphine: effects of single doses and precipitation of acute abstinence syndromes during addiction to morphine; methadone or heroin in man (post addicts).
Topics: Behavior, Addictive; Heroin; Humans; Male; Methadone; Morphine; Nalorphine; Substance-Related Disorders; Syndrome | 1953 |
Effects of hydergine (CCK No. 179) on the modification of tolerance to morphine and l-isomethadone hyperglycemia in rabbits.
Topics: Animals; Drug Tolerance; Ergoloid Mesylates; Ergot Alkaloids; Hyperglycemia; Methadone; Morphine; Rabbits | 1953 |
[Effect of drugs on the metabolism of pyruvate in fetuses and young animals. II. Morphine and synthetic morphine simulants].
Topics: Animals; Central Nervous System; Fetus; Liver; Meperidine; Methadone; Morphine; Pyruvates; Pyruvic Acid | 1953 |
The depression of respiration by the opiates and its antagonism by nalorphine.
Topics: Analgesics, Opioid; Depression; Depressive Disorder; Humans; Meperidine; Methadone; Morphine; Nalorphine; Respiration | 1953 |
RAPID diagnosis of addiction to morphine.
Topics: Behavior, Addictive; Methadone; Morphine; Morphine Dependence; Nalorphine; Substance-Related Disorders | 1954 |
Lower limb reflexes of a "chronic spinal" man in cycles of morphine and methadone addition.
Topics: Behavior, Addictive; Humans; Lower Extremity; Male; Methadone; Morphine; Morphine Dependence; Reflex; Substance-Related Disorders | 1954 |
[The effect of morphine, pethidine and methadon on peristaltic activity of intestines].
Topics: Intestines; Meperidine; Methadone; Morphine; Peristalsis | 1954 |
Effect of adrenaline on the analgesic response of mice to morphine and related drugs.
Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Animals; Epinephrine; Meperidine; Methadone; Mice; Morphine; Pain Management | 1955 |
Synthetic substances with morphine-like effect; relationship between chemical structure and analgesic action.
Topics: Analgesics; Methadone; Morphine | 1955 |
The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.
Topics: Acetylcholine; Codeine; Drug Tolerance; Guinea Pigs; Heroin; Ileum; Intestines; Meperidine; Methadone; Morphine; Nalorphine | 1957 |
[Action of various synthetic analgesics in comparison with morphine & its derivatives].
Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Ephedrine; Meperidine; Methadone; Morphine; Pain Management | 1957 |
[Effects of polamidone on stimulation of the respiration center, as compared with morphine].
Topics: Cell Respiration; Humans; Methadone; Morphine; Respiration | 1957 |
[Comparative analgesic effects of promedol, phenadone, tecodine, and morphine].
Topics: Analgesics; Humans; Methadone; Morphine; Promedol | 1956 |
A new series of potent analgesics: dextro 2:2-diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine and related basic amides. II. Comparative analgesic activity, acute toxicity and tolerance development in rats for R875, morphine, pethidine and methadone.
Topics: Amides; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Biphenyl Compounds; Drug Tolerance; Meperidine; Methadone; Morphine; Rats | 1958 |
A study of the selective antagonism by N-allylnormorphine against meperidine, methadone, and morphine.
Topics: Meperidine; Methadone; Morphine; Nalorphine | 1958 |
[Nil nocere; Hazards of medical treatment of accident injuries caused by alcohol (with barbiturates, morphine and polamidone)].
Topics: Accidents; Barbiturates; Ethanol; Humans; Methadone; Morphine | 1958 |
Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Antipyretics; Cell Respiration; Codeine; Dextromoramide; Gastrointestinal Tract; Guinea Pigs; Meperidine; Methadone; Morphine; Nalorphine; Pain; Pain Threshold; Rats; Respiration; Respiratory Rate | 1959 |
Effect of ephedrine on morphine and methadone hyperglycaemia.
Topics: Ephedrine; Hyperglycemia; Methadone; Morphine | 1959 |
[Semiquantitative determination of physical dependence in morphine and methadon therapy].
Topics: Depression; Depressive Disorder; Humans; Methadone; Morphine; Morphine Dependence; Substance-Related Disorders | 1959 |
Multiple toe-pinch method for testing analgesic drugs.
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Aspirin; Chlorpromazine; Codeine; Guinea Pigs; Humans; Lysergic Acid Diethylamide; Male; Meperidine; Methadone; Morphine; Nalorphine; Phencyclidine; Phthalic Acids; Rats; Toes | 1961 |
[The antagonism of "Lethidron" (N-alyl-morphine) against morphine and methadone in intraduodenal application].
Topics: Methadone; Morphine; Nalorphine | 1960 |
[The effect of various pharmacological agents (amphetamine, cocaine, caffeine, hexobarbital, meprobamate, morphine, dextromoramide, 1-methadone, pethidine and CT 3570) on the time of exhaustion and behavior of animals swimming at 20 degrees C].
Topics: Amphetamine; Amphetamines; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Behavior; Caffeine; Central Nervous System Stimulants; Cocaine; Dextromoramide; Hexobarbital; Hypnotics and Sedatives; Meperidine; Meprobamate; Methadone; Morphine; Physical Exertion; Swimming; Tomography, X-Ray Computed | 1960 |
[Lorfan, a new morphine antagonist in poisonings in children].
Topics: Child; Humans; Infant; Levallorphan; Methadone; Morphine; Musculoskeletal Physiological Phenomena; Poisoning | 1960 |
Cross-cellular adaptation to methadone and meperidine in cerebral cortical slices from morphinized rats.
Topics: Animals; Cerebral Cortex; Meperidine; Methadone; Morphine; Rats | 1962 |
Management of the narcotic withdrawal syndrome in the neonate.
Topics: Barbiturates; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Morphine; Narcotics; Pregnancy; Substance Withdrawal Syndrome; Substance-Related Disorders; Tranquilizing Agents | 1963 |
[Behavior modifiers inthe study of bile ducts. (Combined action of morphine substances and cholecystokinin)].
Topics: Ampulla of Vater; Bile Ducts; Cholecystokinin; Codeine; Dextromoramide; Hydromorphone; Meperidine; Methadone; Morphine; Opium | 1963 |
The biological disposition of morphine and its surrogates.
Topics: Codeine; Heroin; Humans; Methadone; Morphine; Nalorphine; Narcotic Antagonists | 1962 |
GANGLIONIC ACTIONS OF MUSCARINIC SUBSTANCES.
Topics: Animals; Atropine; Autonomic Nervous System; Cats; Cholinergic Agents; Cocaine; Ganglia; Ganglia, Autonomic; Ganglionic Blockers; Hexamethonium Compounds; Methadone; Morphine; Nicotine; Nictitating Membrane; Parasympathomimetics; Pharmacology; Research | 1963 |
[THE INHIBITION OF MORPHINE, LEVORPHAN, METHADONE AND PETHIDINE ANALGESIA IN MICE BY "SPECIFIC" AND "NONSPECIFIC" ANTAGONISTS].
Topics: Analgesia; Animals; Atropine; Levorphanol; Meperidine; Mephenesin; Meprobamate; Methadone; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pain Management; Peptides; Phenobarbital; Research; Reserpine; Tissue Extracts | 1963 |
AN ATTEMPT TO DEMONSTRATE CEILING EFFICACY OF ANALGESICS IN RATS.
Topics: Aminopyrine; Amphetamine; Amphetamines; Analgesics; Aspirin; Barbiturates; Chlordiazepoxide; Chlorpromazine; Codeine; Dextropropoxyphene; Diphenhydramine; Meperidine; Meprobamate; Methadone; Morphine; Pharmacology; Phenobarbital; Rats; Rectum; Research; Toxicology | 1964 |
ELEVATION OF PLASMA HISTAMINE LEVELS IN THE DOG FOLLOWING ADMINISTRATION OF MUSCLE RELAXANTS, OPIATES AND MACROMOLECULAR POLYMERS.
Topics: Acacia; Analgesics, Opioid; Blood Chemical Analysis; Codeine; Dextrans; Diatrizoate; Dogs; Histamine; Meperidine; Mesylates; Methadone; Morphine; Muscle Relaxants, Central; Niacin; Nicotinic Acids; Pharmacology; Povidone; Research; Starch; Succinylcholine; Tubocurarine | 1964 |
ANALGESICS FOR THE RELIEF OF PAIN. I. NARCOTIC ANALGESICS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Codeine; Humans; Hydromorphone; Meperidine; Methadone; Morphine; Narcotics; Oxymorphone; Pain; Phenazocine; Piperidines | 1964 |
USE OF DRUGS IN THE TREATMENT OF RHEUMATOID ARTHRITIS.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Aspirin; Chloroquine; Codeine; Humans; Hydroxychloroquine; Methadone; Morphine; Oxyphenbutazone; Phenylbutazone; Toxicology | 1964 |
[RE-ANESTHESIA].
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, General; Anesthesiology; Atropa belladonna; Atropine; Barbiturates; Chlorpromazine; Dihydroergotoxine; Ergot Alkaloids; Humans; Meperidine; Methadone; Morphine; Procainamide; Promazine; Promethazine; Reserpine; Scopolamine | 1964 |
STATISTICS AS APPLIED TO PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING.
Topics: Arsphenamine; Atropine; Biological Assay; Biometry; Cocaine; Digoxin; Epinephrine; Ergonovine; Ergot Alkaloids; Hexamethonium Compounds; Histamine; Insulin; Meperidine; Methadone; Morphine; Pharmacology; Promethazine; Research; Riboflavin; Statistics as Topic; Strophanthins; Toxicology; Tubocurarine | 1963 |
STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS. I. ABSOLUTE CONFIGURATION OF CERTAIN ANALGESIC (-)-N-(2-(PHENALKYLMETHYLAMINO)PROPYL)PROPIONANILIDES.
Topics: Analgesics; Analgesics, Non-Narcotic; Anilides; Antipyretics; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Meperidine; Methadone; Morphine; Pharmacology; Pharmacy; Research | 1964 |
QUANTITATIVE STUDIES OF THE ANTAGONISM BY NALORPHINE OF SOME OF THE ACTIONS OF MORPHINE-LIKE ANALGESIC DRUGS.
Topics: Analgesics; Animals; Body Temperature; Dextromoramide; Lens, Crystalline; Levorphanol; Meperidine; Methadone; Mice; Morphine; Nalorphine; Narcotic Antagonists; Pharmacology; Research; Skin | 1964 |
A RAPID SCREENING TEST FOR POTENTIAL ADDICTION LIABILITY OF NEW ANALGESIC AGENTS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Behavior, Addictive; Codeine; Dextropropoxyphene; Heroin; Hydromorphone; Meperidine; Methadone; Mice; Morphine; Phenazocine; Research; Substance-Related Disorders; Toxicology | 1964 |
THE ACTION OF MORPHINE-LIKE DRUGS ON IMPULSE TRANSMISSION IN MAMMALIAN NERVE FIBRES.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Cats; Conditioning, Psychological; Hypogastric Plexus; Lagomorpha; Mammals; Meperidine; Methadone; Morphine; Nalorphine; Nerve Fibers; Neural Conduction; Nictitating Membrane; Pharmacology; Rabbits; Research; Sympathetic Nervous System | 1964 |
THE IMPORTANCE OF STERIC CONFIGUA. ION IN CERTAIN MORPHINNE-MIMETIC ACTIONS OF SYNTHETIC ANALGETICS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone; Mice; Morphine; Nalorphine; Pain; Pharmacology; Proadifen; Research; Seizures; Toxicology | 1964 |
THE INHIBITION OF AUTONOMIC NEURO-EFFECTOR TRANSMISSION BY MORPHINE-LIKE DRUGS AND ITS USE AS A SCREENING TEST FOR NARCOTIC ANALGESIC DRUGS .
Topics: Alkaloids; Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Autonomic Agents; Cats; Guinea Pigs; Levallorphan; Levorphanol; Methadone; Morphine; Narcotics; Neuromuscular Junction; Nictitating Membrane; Opium; Pharmacology; Phenothiazines; Research | 1964 |
GAS CHROMATOGRAPHY OF HIGH-BOILING AMINES. II. DETERMINATION OF AMINES IN LOW CONCENTRATION.
Topics: Amines; Chemistry, Pharmaceutical; Chromatography; Chromatography, Gas; Cocaine; Codeine; Ephedrine; Lidocaine; Methadone; Morphine; Pharmacy; Promazine; Research; Scopolamine | 1964 |
[CONTROLLABLE APNEA IN ANESTHESIA BY MEANS OF CENTRAL DEPRESSION DUE TO ANALGESICS].
Topics: Analgesics; Anesthesia; Apnea; Central Nervous System Agents; Depression; Dextromoramide; Humans; Meperidine; Methadone; Morphine; Nalorphine | 1964 |
FLUOROMETRIC IDENTIFICATION OF SUB-MICROGRAM AMOUNTS OF MORPHINE AND RELATED COMPOUNDS ON THIN-LAYER CHROMATOGRAPHS.
Topics: Chemistry, Pharmaceutical; Chromatography; Fluorescence; Fluorometry; Meperidine; Methadone; Morphine; Nalorphine; Research | 1964 |
CARDIOVASCULAR ACTIONS OF NARCOTIC ANALGESICS.
Topics: Cardiovascular Diseases; Drug Therapy; Humans; Meperidine; Methadone; Morphine; Narcotics; Pharmacology; Toxicology | 1965 |
RELATIVE POTENCY OF CODEINE, METHADONE AND DIHYDROMORPHINONE TO MORPHINE IN SELF-MAINTAINED ADDICT RATS.
Topics: Codeine; Hydromorphone; Methadone; Morphine; Morphine Dependence; Periodicity; Pharmacology; Rats; Research | 1965 |
A METHOD FOR THE THIN-LAYER CHROMATOGRAPHY OF ANALGESIC DRUGS AND RELATED COMPOUNDS IN NON-AQUEOUS SYSTEMS.
Topics: Ammonia; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Azepines; Chromatography; Chromatography, Thin Layer; Cocaine; Codeine; Dextropropoxyphene; Isonipecotic Acids; Meperidine; Methadone; Morphine; Research | 1965 |
EFFECT OF CENTRAL DEPRESSANT AGENTS ON CEREBRAL GLUCOSE 6-PHOSPHATE DEHYDROGENASE ACTIVITY OF RATS.
Topics: Adrenal Glands; Brain; Chloroform; Erythrocytes; Ethanol; Glucose; Glucosephosphate Dehydrogenase; Kidney; Liver; Meperidine; Methadone; Morphine; NADP; Nalorphine; Pentobarbital; Pharmacology; Phosphates; Rats; Research; Spleen; Sulfhydryl Compounds | 1965 |
[ON THE MORPHINE-LIKE PROPERTIES OF A NEW ANTITUSSIVE (ISOAMINIL; PERACON, MULLATUSS)].
Topics: Acetonitriles; Antitussive Agents; Codeine; Cyanides; Electron Transport Complex IV; Methadone; Mice; Morphine; Nalorphine; Pharmacology; Rats; Research; Respiration; Toxicology | 1964 |
Rat tissue levels of carbon-14 labeled analgetics as related to pharmacological activity.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Central Nervous System; Codeine; Methadone; Morphine; Rats | 1955 |
[Analgetic effect of morphine, dolsin and mecodin in various ways of application; a pharmacological study].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Meperidine; Methadone; Morphine; Pain; Pain Management | 1955 |
[Action of various pharmacological agents on the exhaustion time and behavior of mice swimming at 20 degrees C. II. Analgesics (morphine, dextromoramide, methadone, pethidine and 3570 CT). Influence of repetition of the test].
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Dextromoramide; Fatigue; Leadership; Meperidine; Methadone; Mice; Morphine; Physical Exertion; Swimming; Tomography, X-Ray Computed | 1962 |
[Action of Phenampromid on the central nervous system, with special reference to comparison with methadone and morphine].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Central Nervous System; Methadone; Morphine; Propionates | 1961 |
Antinociceptive interactions of ketamine with morphine or methadone in mononeuropathic rats.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Injections, Subcutaneous; Ketamine; Male; Methadone; Mononeuropathies; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, mu | 2003 |
Methadone for the treatment of pain #75.
Topics: Administration, Oral; Analgesia; Analgesics, Opioid; Drug Administration Schedule; Half-Life; Humans; Methadone; Morphine | 2003 |
Mu-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Humans; In Vitro Techniques; Kidney; Locus Coeruleus; Male; Methadone; Morphine; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Opioid, mu; Transfection | 2003 |
Dosage regimes in the prescription of heroin and other narcotics to chronic opioid addicts in Switzerland--Swiss national cohort study.
Topics: Administration, Oral; Adult; Ambulatory Care; Clinical Trials as Topic; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Prescriptions; Drug Utilization; Female; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Male; Methadone; Morphine; Narcotics; Outcome and Process Assessment, Health Care; Substance Abuse Detection; Substance Abuse, Intravenous; Switzerland | 2004 |
The action of morphine, pethidine, and amidone upon the intestinal motility of conscious dogs.
Topics: Animals; Consciousness; Dogs; Gastrointestinal Motility; Humans; Intestines; Meperidine; Methadone; Morphine | 1950 |
METHADONE Army develops perfect substitute for morphine.
Topics: Methadone; Military Medicine; Military Personnel; Morphine; Naval Medicine | 1951 |
[Use of polamidon in morphine withdrawal].
Topics: Humans; Methadone; Morphine | 1950 |
The effects of morphine methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation.
Topics: Animals; Meperidine; Methadone; Morphine; Reflex | 1951 |
[Determination of polamidon and dolantin in the urine, and their separation from morphine].
Topics: Body Fluids; Meperidine; Methadone; Morphine; Rare Diseases; Retinal Degeneration; Retinal Detachment; Urine | 1951 |
The effect of methadone isomers, morphine, and pentobarbital on the blood glucose of dogs.
Topics: Animals; Barbital; Blood Glucose; Dogs; Methadone; Morphine; Pentobarbital | 1951 |
[Effect of morphine, dolantin and polamidon on the small intestine of man].
Topics: Intestine, Small; Intestines; Meperidine; Methadone; Morphine | 1951 |
A comparison of heat and pressure analgesiometric methods in rats.
Topics: Animals; Hot Temperature; Methadone; Morphine; Pain; Pressure; Rats | 1951 |
Use of n-allylnormorphine in treatment of methadone poisoning in man; report of two cases.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Hypnotics and Sedatives; Male; Methadone; Morphine; Nalorphine | 1952 |
SUBSTITUTE for morphine.
Topics: Humans; Methadone; Morphine | 1952 |
Reactions of dogs without neocortex during cycles of addiction to morphine and methadone.
Topics: Animals; Behavior, Addictive; Dogs; Humans; Methadone; Morphine; Neocortex; Substance-Related Disorders | 1952 |
Functional inhibition by methadone of N-methyl-D-aspartate receptors expressed in Xenopus oocytes: stereospecific and subunit effects.
Topics: Animals; Binding, Competitive; Electrophysiology; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Kinetics; Methadone; Morphine; Narcotics; Oocytes; Rats; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship; Xenopus laevis | 2004 |
Switching to methadone: 'ad libitum' or fixed dose ratio?
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain; Patient Satisfaction | 2004 |
Withdrawal symptoms during chronic transdermal fentanyl administration managed with oral methadone.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Substance Withdrawal Syndrome | 2004 |
Modulation of the discriminative stimulus effects of mu opioid agonists in rats: I. Effects of dopamine D2/3 antagonists.
Topics: Animals; Benzazepines; Brain; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Flupenthixol; Heroin; Methadone; Morphine; Motivation; Nalbuphine; Naphthalenes; Piperazines; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, Opioid, mu; Salicylamides | 2004 |
Modulation of the discriminative stimulus effects of mu opioid agonists in rats: II. Effects of dopamine D2/3 agonists.
Topics: Animals; Appetitive Behavior; Brain; Discrimination Learning; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Heroin; Male; Methadone; Morphine; Motivation; Nalbuphine; Quinolines; Quinpirole; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Opioid, mu; Tetrahydronaphthalenes | 2004 |
Comparison of the antinociceptive effect of morphine, methadone, buprenorphine and codeine in two substrains of Sprague-Dawley rats.
Topics: Analgesics; Animals; Buprenorphine; Codeine; Injections, Subcutaneous; Male; Methadone; Morphine; Morphine Derivatives; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors | 2004 |
"Opioid creep" is real and may be the cause of "fluid creep".
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Body Surface Area; Burns; Female; Fentanyl; Fluid Therapy; Humans; Hypnotics and Sedatives; Male; Meperidine; Methadone; Middle Aged; Morphine; Narcotics; Retrospective Studies | 2004 |
Antidepressant-like effect of tramadol and its enantiomers in reserpinized mice: comparative study with desipramine, fluvoxamine, venlafaxine and opiates.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Blepharoptosis; Body Temperature; Cyclohexanols; Desipramine; Fluvoxamine; Levorphanol; Male; Methadone; Mice; Morphine; Narcotics; Reserpine; Stereoisomerism; Time Factors; Tramadol; Venlafaxine Hydrochloride | 2004 |
[Polamidon as a spasmolytic and analgesic].
Topics: Analgesics; Humans; Methadone; Morphine; Pain; Parasympatholytics; Spasm | 1950 |
[Polamidon addiction].
Topics: Behavior, Addictive; Humans; Methadone; Morphine; Pharmaceutical Preparations | 1950 |
Effects of methadone and morphine of the electroencephalogram of the dog.
Topics: Animals; Central Nervous System; Central Nervous System Depressants; Dogs; Electroencephalography; Methadone; Morphine; Nervous System | 1950 |
[Polamidon addiction].
Topics: Behavior, Addictive; Humans; Methadone; Morphine; Pharmaceutical Preparations | 1950 |
A comparison of the actions of meperidine, Nu-1196, methadone, morphine, Nu-2206, and metopon upon the intestine and uterus.
Topics: Female; Humans; Intestines; Meperidine; Methadone; Morphinans; Morphine; Uterus | 1950 |
[Abuse of polamidon].
Topics: Humans; Mental Disorders; Methadone; Morphine; Pharmaceutical Preparations; Substance-Related Disorders | 1950 |
Intravenous ketamine infusion as an adjuvant to morphine in a 2-year-old with severe cancer pain from metastatic neuroblastoma.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Child, Preschool; Codeine; Drug Therapy, Combination; Dyspnea; Fatal Outcome; Female; Hallucinations; Humans; Infusions, Intravenous; Ketamine; Methadone; Morphine; Neuroblastoma; Pain, Intractable; Palliative Care; Quality of Life | 2004 |
Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Cell Line, Tumor; Electron Transport Complex IV; Fentanyl; Free Radicals; Glioma; Humans; Membrane Potentials; Methadone; Microscopy, Fluorescence; Mitochondria; Morphine; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Signal Transduction; Spectrophotometry; Time Factors | 2004 |
Opioid poisoning deaths in New Zealand (2001-2002).
Topics: Adolescent; Adult; Aged; Dextropropoxyphene; Drug and Narcotic Control; Drug Prescriptions; Female; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; New Zealand; Poisoning; Suicide | 2005 |
Profound morphine tolerance following high-dose methadone therapy.
Topics: Analgesics; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Methadone; Middle Aged; Morphine; Pain | 2004 |
Opioid poisoning deaths in New Zealand.
Topics: Humans; Methadone; Morphine; Narcotics; New Zealand; Opioid-Related Disorders | 2005 |
Opioid rotation from methadone: fraught with difficulties.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Liver Neoplasms; Male; Methadone; Morphine; Pain; Treatment Outcome | 2005 |
An opiate cocktail that reduces morphine tolerance and dependence.
Topics: Analysis of Variance; Animals; Biotin; Blotting, Western; Cyclic AMP; Drug Combinations; Drug Tolerance; Endocytosis; Immunohistochemistry; Luciferases; Methadone; Morphine; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Substance-Related Disorders | 2005 |
Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Animal; Male; Methadone; Morphine; Motor Activity; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Rotarod Performance Test; Sciatic Neuropathy; Spinal Cord Injuries; Time Factors | 2005 |
Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat.
Topics: Animals; Ethanol; Heroin; Heroin Dependence; Male; Methadone; Microsomes, Liver; Morphine; Morphine Derivatives; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2005 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidinones; Reaction Time; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2005 |
Simplified methadone conversion.
Topics: Administration, Oral; Algorithms; Analgesics, Opioid; Humans; Methadone; Morphine; Palliative Care; United States | 2005 |
Morphine tolerance as a function of ratio schedule: response requirement or unit price?
Topics: Animals; Behavior, Animal; Cocaine; Columbidae; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Female; Methadone; Morphine; Narcotics; Reinforcement Schedule; Reinforcement, Psychology | 2005 |
Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Interactions; Female; Heroin; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Plethysmography, Whole Body; Quaternary Ammonium Compounds; Respiration; Respiratory Insufficiency; Substance Withdrawal Syndrome | 2006 |
A retrospective study of length of hospital stay in infants treated for neonatal abstinence syndrome with methadone versus oral morphine preparations.
Topics: Administration, Oral; Female; Hospitalization; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Retrospective Studies | 2005 |
Opiate maintenance alternatives: new studies.
Topics: Buprenorphine; Humans; Methadone; Morphine; Narcotic Antagonists; Narcotics; Opioid-Related Disorders | 2005 |
HPLC-DAD determination of opioids, cocaine and their metabolites in plasma.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Cocaine; Codeine; Dopamine Uptake Inhibitors; Female; Forensic Medicine; Humans; Male; Methadone; Morphine; Morphine Derivatives; Pyrrolidines | 2006 |
Management of neonatal abstinence syndrome in neonatal intensive care units: a national survey.
Topics: Humans; Hypnotics and Sedatives; Infant, Newborn; Injections, Intravenous; Intensive Care Units, Neonatal; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Psychomotor Performance; Surveys and Questionnaires; Treatment Outcome | 2006 |
Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; Female; Follow-Up Studies; Humans; Male; Methadone; Middle Aged; Morphine; Pain; Patient Satisfaction; Prospective Studies | 2006 |
The effect of FDA approval of a generic competitor to OxyContin (oxycodone HCl controlled-release) tablets on the abuse of oxycodone.
Topics: Analgesics, Opioid; Catchment Area, Health; Delayed-Action Preparations; Drug Approval; Drug Prescriptions; Drugs, Generic; Humans; Hydrocodone; Methadone; Morphine; Oxycodone; Poison Control Centers; Population Surveillance; Prevalence; Substance-Related Disorders; United States; United States Food and Drug Administration | 2006 |
Prescription drug dependence and evolving beliefs about chronic pain management.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Prescriptions; Drug Tolerance; Drug Utilization; Female; Humans; Hyperalgesia; Methadone; Morphine; Pain; Physician-Patient Relations; Receptors, Opioid; Substance-Related Disorders | 2006 |
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat.
Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Methadone; Morphine; Neuralgia; Oxycodone; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Spinal Nerves | 2006 |
Anesthesia and pain management for pediatric patients with dystrophic epidermolysis bullosa.
Topics: Adolescent; Anesthesia, General; Child; Child, Preschool; Conscious Sedation; Epidermolysis Bullosa Dystrophica; Female; Humans; Hydromorphone; Infant; Male; Methadone; Morphine; Pain; Perioperative Care; Postoperative Complications; Preoperative Care; Retrospective Studies | 2006 |
Opiate pharmacology of intrathecal granulomas.
Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Granuloma; Injections, Spinal; Male; Maximum Tolerated Dose; Methadone; Morphine; Spinal Cord | 2006 |
Changes to the daily pattern of methadone-related deaths in England and Wales, 1993-2003.
Topics: Death Certificates; Drug Overdose; England; Heroin; Holidays; Humans; Methadone; Morphine; Narcotics; Periodicity; Risk Assessment; Substance Abuse Treatment Centers; Substance-Related Disorders; Time Factors; Wales | 2006 |
Trends and geographic variation of opiate medication use in state Medicaid fee-for-service programs, 1996 to 2002.
Topics: Analgesics, Opioid; Data Interpretation, Statistical; Drug Prescriptions; Drug Utilization; Fee-for-Service Plans; Humans; Hydrocodone; Medicaid; Methadone; Models, Theoretical; Morphine; Oxycodone; Pain; Practice Patterns, Physicians'; United States | 2006 |
Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cats; Female; Hot Temperature; Injections, Subcutaneous; Male; Methadone; Morphine; Pain; Pain Measurement; Pressure | 2006 |
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Indophenol; Levorphanol; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Stereotyped Behavior; Tics; Tourette Syndrome; Tramadol; Triazoles | 2007 |
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroin; Hydromorphone; Infusions, Intravenous; Injections, Spinal; Male; Methadone; Morphine; Neuralgia; Pain; Rats; Rats, Inbred F344; Self Administration | 2007 |
Characterization of the antinociceptive and pronociceptive effects of methadone in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Male; Methadone; Morphine; Nociceptors; Rats; Rats, Sprague-Dawley; Sex Factors; Time Factors | 2007 |
Medicating "Margaret".
Topics: Advance Directives; Alzheimer Disease; Analgesics, Opioid; Antipsychotic Agents; Electroconvulsive Therapy; Female; Fentanyl; Hospice Care; Humans; Lorazepam; Methadone; Middle Aged; Morphine; Oxycodone; Pain; Palliative Care; Psychomotor Agitation; Right to Die | 2006 |
Blockade of morphine-induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments.
Topics: Amisulpride; Animals; Behavior, Animal; Buprenorphine; Disulfides; Male; Methadone; Mice; Morphine; Motor Activity; Opioid-Related Disorders; Phenylalanine; Sulpiride | 2007 |
The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Methadone; Morphine; Morphine Dependence; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2007 |
Development and validation of the Cozart DDS oral fluid collection device.
Topics: Amphetamines; Automobile Driving; Cocaine; Dopamine Uptake Inhibitors; Dronabinol; Forensic Toxicology; Hallucinogens; Humans; Hypnotics and Sedatives; Methadone; Morphine; Narcotics; Saliva; Substance Abuse Detection; Temazepam | 2007 |
Prescribing patterns and purchasing costs of long-acting opioids over nine years at an academic oncology hospital.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Costs; Drug Utilization; Fentanyl; Humans; Methadone; Morphine; Oxycodone; Time Factors | 2007 |
Microwave-assisted extraction and HPLC-DAD determination of drugs of abuse in human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Cocaine; Codeine; Forensic Medicine; Humans; Illicit Drugs; Methadone; Microwaves; Morphine; Pyrrolidines; Reproducibility of Results; Solvents; Spectrophotometry, Atomic; Substance Abuse Detection | 2007 |
NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats.
Topics: Animals; Behavior, Animal; Buprenorphine; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Memantine; Methadone; Morphine; Motor Activity; Narcotics; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2008 |
Hospital morphine preparation for abstinence syndrome in newborns exposed to buprenorphine or methadone.
Topics: Buprenorphine; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Female; Humans; Infant, Newborn; Methadone; Morphine; Narcotic Antagonists; Narcotics; Neonatal Abstinence Syndrome; Pharmaceutical Solutions; Pregnancy; Prospective Studies | 2008 |
Buprenorphine + naloxone: new combination. Opiate dependence: no proof of reduced risk of self-administered injection.
Topics: Administration, Sublingual; Analgesics, Opioid; Buprenorphine; Drug Therapy, Combination; Finland; France; Heroin Dependence; Humans; Methadone; Morphine; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Patient Compliance; Patient Dropouts; Randomized Controlled Trials as Topic; Self Administration; Treatment Outcome | 2007 |
Levorphanol revisited.
Topics: Analgesics, Opioid; Levorphanol; Methadone; Morphine | 2007 |
A comparison of certain actions of demerol and methadone.
Topics: Humans; Meperidine; Methadone; Morphine; Narcotics | 1949 |
Hindlimb reflexes of chronic spinal dots during cycles of addiction to morphine and methadon.
Topics: Animals; Behavior, Addictive; Hindlimb; Methadone; Morphine; Reflex | 1948 |
Inhibition of succinic oxidase system by meperidine, methadon, morphine, and codeine.
Topics: Codeine; Coloring Agents; Meperidine; Methadone; Morphine; Oxidoreductases; Peroxidase; Peroxidases; Succinate Dehydrogenase | 1949 |
Comparative investigations in to the analgesic effects of morphine and d, 1-6-dimethylamino-4,4-diphenyl-3-heptanone hydrochloride.
Topics: Analgesics; Biphenyl Compounds; Diphenhydramine; Humans; Ketones; Methadone; Morphine | 1949 |
The addiction liability of methadon (amidone, dolophine, 10820) and its use in the treatment of the morphine abstinence syndrome.
Topics: Behavior, Addictive; Humans; Industry; Methadone; Morphine; Morphine Dependence; Occupations; Syndrome | 1949 |
Prescribing methadone for pain management in end-of-life care.
Topics: Drug Interactions; Humans; Methadone; Morphine; Pain; Palliative Care; Terminal Care | 2005 |
OCCURRENCE IN RODENTS OF REVERSIBLE DRUG-INDUCED OPACITIES OF THE LENS.
Topics: Analgesics, Opioid; Animals; Cataract; Chickens; Guinea Pigs; Humans; Injections, Subcutaneous; Lens Capsule, Crystalline; Lens, Crystalline; Meperidine; Methadone; Mice; Morphine; Pupil; Rats; Recovery of Function | 1961 |
Methadone: does it really have low efficacy at micro-opioid receptors?
Topics: Animals; Animals, Newborn; Cell Line, Transformed; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Locus Coeruleus; Membrane Potentials; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Protein Binding; Rats; Receptors, Opioid, mu; Transfection | 2008 |
Chronic exposure of human macrophages in vitro to morphine and methadone induces a putative tolerant/dependent state.
Topics: Adolescent; Adult; Analysis of Variance; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; Macrophages; Male; Methadone; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Substance Withdrawal Syndrome; Time Factors | 2008 |
Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Methadone; Morphine; Motor Activity; Narcotics; Neostriatum; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2008 |
Neonatal abstinence syndrome.
Topics: Female; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal Exchange; Methadone; Morphine; Mothers; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Retrospective Studies; Scotland; Time Factors; Treatment Outcome | 2008 |
Mu-opioid receptor activation in live cells.
Topics: Animals; Cell Membrane; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Green Fluorescent Proteins; Humans; Membrane Lipids; Methadone; Models, Biological; Morphine; PC12 Cells; Rats; Receptors, Opioid, mu | 2008 |
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Catheters, Indwelling; Chemokine CX3CL1; Cytokines; Hyperalgesia; Injections, Spinal; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Methadone; Morphine; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor, Type I; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Time Factors | 2008 |
Differential activation and trafficking of micro-opioid receptors in brain slices.
Topics: Analgesics, Opioid; Animals; Brain; Chelating Agents; Egtazic Acid; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fluorescent Antibody Technique, Direct; Locus Coeruleus; Methadone; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neurons; Oxycodone; Oxymorphone; Protein Transport; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Time Factors | 2008 |
Nails of newborns in monitoring drug exposure during pregnancy.
Topics: Caffeine; Central Nervous System Stimulants; Cocaine; Cotinine; Dopamine Uptake Inhibitors; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Morphine; Nails; Narcotics; Nicotine; Nicotinic Agonists; Pregnancy; Smoking | 2008 |
Management of acute pain in methadone maintenance therapy in-patients.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Australia; Dose-Response Relationship, Drug; Female; Humans; Inpatients; Male; Methadone; Morphine; Pain; Pain Measurement; Retrospective Studies; Substance Abuse Treatment Centers | 2008 |
The underrecognized toll of prescription opioid abuse on young children.
Topics: Adverse Drug Reaction Reporting Systems; Analgesics, Opioid; Buprenorphine; Child, Preschool; Female; Humans; Hydrocodone; Hydromorphone; Infant; Infant, Newborn; Male; Methadone; Morphine; Oxycodone; Poisoning; Prescription Drugs; United States | 2009 |
So much for harm reduction techniques reducing drug deaths.
Topics: Adult; Harm Reduction; Heroin Dependence; Humans; Methadone; Morphine; Narcotics | 2008 |
Influence of amidone, morphine and strychine on the Straub-tail-test of white mice.
Topics: Animals; Methadone; Mice; Morphine; Morphine Derivatives | 1948 |
Analgesic effects in human subjects of morphine, meperidina and methadon.
Topics: Analgesics; Humans; Meperidine; Methadone; Morphine; Morphine Derivatives | 1948 |
An electroencephalographic analysis of the action of amidone, morphine and strychnine on the central nervous system.
Topics: Central Nervous System; Central Nervous System Depressants; Electroencephalography; Humans; Methadone; Morphine; Strychnine | 1948 |
Pharmacology of methadone and related compounds.
Topics: Humans; Methadone; Morphine; Morphine Derivatives | 1948 |
Observations on the comparative pharmacologic actions of 6-dimethylamino-4,4-diphenyl-3-heptanone (amidone) and morphine.
Topics: Biphenyl Compounds; Ketones; Methadone; Morphine | 1948 |
Acute vascular tolerance to morphine, isonipecaine (demerol) and methadon (amidone) in the dog.
Topics: Animals; Blood Vessels; Dogs; Drug Tolerance; Immune Tolerance; Meperidine; Methadone; Morphine | 1948 |
Physical dependence liability of drugs of the methadon series and of 6-methyldihydromorphine.
Topics: Behavior, Addictive; Methadone; Morphine; Morphine Derivatives; Substance-Related Disorders | 1948 |
Electroencephalographic analysis of action of amidone, morphine and strychnine on the central nervous system.
Topics: Central Nervous System; Central Nervous System Depressants; Electroencephalography; Humans; Methadone; Morphine; Morphine Derivatives; Strychnine | 1948 |
A comparison of side actions and analgesic effects of morphine, amidone, (4-4-diphenyl-6-dimethylamino-heptanone-3) and its isomers in man.
Topics: Analgesics; Biphenyl Compounds; Diphenhydramine; Isomerism; Ketones; Methadone; Morphine; Morphine Derivatives | 1948 |
[Analgesics and palliative care].
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pain; Palliative Care; Patient Care Team; Terminal Care | 2008 |
Slow-release oral morphine for maintenance treatment of opioid addicts intolerant to methadone or with inadequate withdrawal suppression.
Topics: Adult; Delayed-Action Preparations; Female; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; Opioid-Related Disorders; Prospective Studies; Quality of Life; Substance Withdrawal Syndrome; Treatment Outcome | 2008 |
European pain management discussion forum.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Europe; Herpes Zoster; Humans; Methadone; Morphine; Neuralgia, Postherpetic; Opioid-Related Disorders; Pain; Pain, Postoperative | 2008 |
Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Tolerance; Female; Humans; Hyperalgesia; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Pain; Pain Measurement; Pain Threshold | 2009 |
Direct subunit-dependent multimodal 5-hydroxytryptamine3 receptor antagonism by methadone.
Topics: Cell Line; Dose-Response Relationship, Drug; Humans; Methadone; Morphine; Protein Subunits; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Stereoisomerism | 2009 |
Morphine-methadone opioid rotation in cancer patients: analysis of dose ratio predicting factors.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain, Intractable; Palliative Care; Predictive Value of Tests | 2009 |
Management of neonatal abstinence syndrome: a national survey and review of practice.
Topics: Anticonvulsants; Breast Feeding; Drug Administration Schedule; Health Care Surveys; Humans; Infant Care; Infant, Newborn; Ireland; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Patient Discharge; Professional Practice; United Kingdom | 2009 |
Methadone antinociception is dependent on peripheral opioid receptors.
Topics: Analgesics, Opioid; Animals; Drug Administration Routes; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Species Specificity | 2009 |
Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit.
Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Pain; Palliative Care; Prospective Studies; Treatment Outcome | 2009 |
Generation and utilization of anti-drug monoclonal antibodies for screening of 36 drug users by dot-ELISA.
Topics: Antibodies, Monoclonal; Barbital; Enzyme-Linked Immunosorbent Assay; Humans; Methadone; Methamphetamine; Morphine; Phencyclidine; Substance Abuse Detection | 2009 |
Route of administration influences substitution patterns in rats trained to discriminate methadone vs. vehicle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Choice Behavior; Conditioning, Operant; Discrimination, Psychological; Heroin; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2009 |
Methadone is substantially less effective than morphine in modifying locomotor and brain Fos responses to subsequent methadone challenge in rats.
Topics: Animals; Brain Chemistry; Male; Methadone; Morphine; Motor Activity; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2009 |
Simultaneous quantification of methadone, cocaine, opiates, and metabolites in human placenta by liquid chromatography-mass spectrometry.
Topics: Adult; Analgesics, Opioid; Chromatography, High Pressure Liquid; Cocaine; Female; Humans; Methadone; Morphine; Morphine Derivatives; Placenta; Pregnancy; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Young Adult | 2009 |
Challenging small human hepatocytes with opiates: further characterization of a novel prototype bioartificial liver.
Topics: Blotting, Western; Cell Count; Cell Culture Techniques; Cell Extracts; Cell Survival; Cells, Cultured; Hepatocytes; Humans; Liver, Artificial; Methadone; Morphine; Opiate Alkaloids | 2010 |
Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats.
Topics: Animals; Blood Gas Analysis; Buprenorphine; Catheterization; Fentanyl; Lactic Acid; Male; Methadone; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiratory Insufficiency; Respiratory Mechanics | 2009 |
Treatment of neonatal abstinence syndrome with clonidine and chloral hydrate.
Topics: Blood Pressure; Chloral Hydrate; Clonidine; Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Retrospective Studies; Treatment Outcome | 2010 |
Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Methadone; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Time Factors | 2009 |
Determinants of successful chronic hepatitis C case finding among patients receiving opioid maintenance treatment in a primary care setting.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Family Practice; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Male; Methadone; Morphine; Narcotics; Polymerase Chain Reaction; Regression Analysis; Retrospective Studies; Substance Abuse, Intravenous; Switzerland | 2009 |
Gas chromatography-mass spectrometry assay for the simultaneous quantification of drugs of abuse in human placenta at 12th week of gestation.
Topics: Abortion, Induced; Amphetamines; Cocaine; Cotinine; Dronabinol; Female; Forensic Toxicology; Ganglionic Stimulants; Gas Chromatography-Mass Spectrometry; Hallucinogens; Humans; Maternal Exposure; Maternal-Fetal Exchange; Methadone; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Nicotine; Placenta; Pregnancy; Pregnancy Trimester, First; Specimen Handling; Substance Abuse Detection | 2010 |
A reduction in blood morphine concentrations amongst heroin overdose fatalities associated with a sustained reduction in street heroin purity.
Topics: Adult; Australia; Benzodiazepines; Central Nervous System Depressants; Drug Contamination; Drug Overdose; Ethanol; Female; Forensic Toxicology; Heroin; Humans; Illicit Drugs; Male; Methadone; Morphine; Narcotics | 2010 |
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Topics: Analgesics, Opioid; Animals; Gliosis; Hyperalgesia; Immunity, Innate; Inflammation; Inflammation Mediators; Injections, Spinal; Interleukin-1; Isomerism; Lymphocyte Antigen 96; Male; Methadone; Microglia; Morphine; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Toll-Like Receptor 4 | 2010 |
A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size.
Topics: Administration, Oral; Analgesia; Analgesics, Opioid; Animals; Brain; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genotype; Heroin; Japan; Methadone; Morphine; Polymorphism, Genetic; Rats; Rats, Wistar; Receptors, Opioid | 2010 |
Acute vascular tolerance to morphine, demerol, and 1,1-diphenyl-1-(dimethylamino-isopropyl) butanone-2 (amidone) in the dog.
Topics: Animals; Biphenyl Compounds; Butanones; Dogs; Drug Tolerance; Humans; Meperidine; Methadone; Morphine | 1947 |
Comparative toxicology of intentional and accidental heroin overdose.
Topics: Accidents; Adult; Body Mass Index; Central Nervous System Depressants; Cocaine; Drug Overdose; Ethanol; Female; Forensic Toxicology; Heroin; Humans; Liver; Lymphocytes; Male; Methadone; Morphine; Narcotics; Sex Distribution; Suicide | 2010 |
Topical methadone and meperidine analgesic synergy in the mouse.
Topics: Administration, Cutaneous; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Lidocaine; Male; Meperidine; Methadone; Mice; Mice, Inbred Strains; Morphine; Pain Measurement | 2010 |
Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.
Topics: Analgesics; Animals; Buprenorphine; Disease Models, Animal; Drug Tolerance; Female; Heroin Dependence; Humans; Male; Methadone; Morphine; Morphine Dependence; Pain Measurement; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2010 |
Gender and NAS: does sex matter?
Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Retrospective Studies; Risk Factors; Sex Characteristics | 2010 |
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestins; beta-Arrestins; Drug Tolerance; Fentanyl; Hot Temperature; Male; Methadone; Mice; Mice, Knockout; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, mu | 2011 |
A hybrid liquid chromatography-mass spectrometry strategy in a forensic laboratory for opioid, cocaine and amphetamine classes in human urine using a hybrid linear ion trap-triple quadrupole mass spectrometer.
Topics: Amphetamines; Calibration; Chromatography, Liquid; Cocaine; Humans; Linear Models; Mass Spectrometry; Methadone; Morphine; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection | 2010 |
CYP2B6 and OPRM1 gene variations predict methadone-related deaths.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Cause of Death; Cytochrome P-450 CYP2B6; Drug Synergism; Gene Frequency; Genetic Carrier Screening; Genetic Predisposition to Disease; Genetic Testing; Genetic Variation; Genotype; Heroin Dependence; Humans; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Oxidoreductases, N-Demethylating; Receptors, Opioid, mu; Risk Factors | 2011 |
Diverse behavioral, monoaminergic and Fos protein responses to opioids in Warsaw high-alcohol preferring and Warsaw low-alcohol preferring rats.
Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Disease Models, Animal; Dopamine; Male; Methadone; Morphine; Motor Activity; Opioid-Related Disorders; Proto-Oncogene Proteins c-fos; Rats; Serotonin | 2011 |
Oral fluid is a viable alternative for monitoring drug abuse: detection of drugs in oral fluid by liquid chromatography-tandem mass spectrometry and comparison to the results from urine samples from patients treated with Methadone or Buprenorphine.
Topics: Benzodiazepines; Buprenorphine; Chromatography, Liquid; Drug Monitoring; Humans; Illicit Drugs; Methadone; Morphine; Morphine Derivatives; Saliva; Substance Abuse Detection; Tandem Mass Spectrometry | 2011 |
Oral fluid results compared to self reports of recent cocaine and heroin use by methadone maintenance patients.
Topics: Cocaine; Cocaine-Related Disorders; Codeine; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Morphine Derivatives; Narcotics; Opiate Substitution Treatment; Saliva; Self Report; Substance Abuse Detection | 2012 |
Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses.
Topics: Administration, Oral; Analgesics, Opioid; Cooperative Behavior; Databases, Factual; Drug Utilization; Fentanyl; Humans; Methadone; Morphine; Norway; Pain; Pain Measurement; Therapeutic Equivalency; World Health Organization | 2011 |
Trends and pattern of drug abuse deaths in Maryland teenagers.
Topics: Adolescent; Age Distribution; Black People; Butanes; Cause of Death; Chlorofluorocarbons, Methane; Cocaine; Female; Forensic Pathology; Forensic Toxicology; Hepatitis B Antibodies; Heroin; HIV Antibodies; Humans; Male; Maryland; Methadone; Morphine; Myocarditis; N-Methyl-3,4-methylenedioxyamphetamine; Narcotics; Nitrous Oxide; Pneumonia; Propane; Retrospective Studies; Sex Distribution; Substance-Related Disorders; White People | 2011 |
Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.
Topics: Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Brain Chemistry; Endocytosis; G-Protein-Coupled Receptor Kinase 2; Male; Methadone; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Morphine; Narcotics; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2011 |
Clinical characteristics and risk behavior as a function of HIV status among heroin users enrolled in methadone treatment in northern Taiwan.
Topics: Adult; Dose-Response Relationship, Drug; Female; Hepatitis C; Heroin Dependence; HIV Seronegativity; HIV Seropositivity; Humans; Interviews as Topic; Male; Mental Disorders; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Quality of Life; Risk-Taking; Sexual Behavior; Socioeconomic Factors; Taiwan | 2011 |
Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.
Topics: Adult; Aged; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Drug Delivery Systems; Female; Humans; Male; Methadone; Middle Aged; Morphine; Pain; Prescription Drugs; Retrospective Studies; Sensitivity and Specificity; Survival Analysis; Treatment Outcome; United States; United States Department of Veterans Affairs | 2011 |
Drug screening of whole blood by ultra-performance liquid chromatography-tandem mass spectrometry.
Topics: Buprenorphine; Chromatography, Liquid; Cocaine; Codeine; Dronabinol; Ethylmorphine; Humans; Illicit Drugs; Methadone; Morphine; Oxycodone; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry | 2011 |
Drug overdose deaths--Florida, 2003-2009.
Topics: Alprazolam; Cause of Death; Cocaine; Drug Overdose; Florida; Humans; Illicit Drugs; Methadone; Morphine; Mortality; Oxycodone; Prescription Drugs | 2011 |
Drug-related death in Denmark in 2007.
Topics: Adolescent; Adult; Age Distribution; Amphetamines; Denmark; Female; Heroin; Humans; Male; Methadone; Middle Aged; Morphine; Narcotics; Prevalence; Risk Factors; Substance-Related Disorders; Young Adult | 2011 |
Inconsistencies in opioid equianalgesic ratios: clinical and research implications.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Delayed-Action Preparations; Drug Dosage Calculations; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Neoplasms; Oxycodone; Pain; Randomized Controlled Trials as Topic | 2008 |
Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Endocytosis; Gene Knock-In Techniques; Methadone; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Mutation; Naloxone; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Substance-Related Disorders | 2012 |
Is maternal opioid use hazardous to breast-fed infants?
Topics: Age Factors; Analgesics, Opioid; Breast Feeding; Buprenorphine; Codeine; Female; Humans; Hydrocodone; Infant; Infant, Newborn; Meperidine; Methadone; Milk, Human; Morphine; Oxycodone | 2012 |
Physical compatibility of binary and ternary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care.
Topics: Analgesics, Opioid; Drug Combinations; Drug Interactions; Humans; Infusions, Parenteral; Ketorolac; Methadone; Morphine; Palliative Care; Reference Standards; Reproducibility of Results | 2012 |
Stop and go strategy for opioid switching requires flexibility.
Topics: Analgesics, Opioid; Drug Substitution; Female; Humans; Male; Methadone; Morphine; Neoplasms; Oxycodone; Pain | 2012 |
A rooming-in program to mitigate the need to treat for opiate withdrawal in the newborn.
Topics: Adult; Breast Feeding; Heroin Dependence; Humans; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Rooming-in Care; Young Adult | 2012 |
Long-term methadone treatment reduces phosphorylation of CaMKII in rat brain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Learning; Male; Memory; Methadone; Mitogen-Activated Protein Kinase 1; Morphine; Phosphorylation; Rats; Rats, Wistar | 2012 |
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
Topics: Adult; Amitriptyline; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Heroin Dependence; Humans; Linkage Disequilibrium; Male; Methadone; Middle Aged; Morphine; Polymorphism, Single Nucleotide; Pyrrolidines; Substance Withdrawal Syndrome; Taiwan | 2012 |
(1) H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention.
Topics: Animals; Brain; Disease Models, Animal; Female; Macaca mulatta; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methadone; Morphine; Morphine Dependence; Narcotics; Substance Withdrawal Syndrome | 2012 |
Comparison of fatal poisonings by prescription opioids.
Topics: Accidents; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Central Nervous System Depressants; Codeine; Dextropropoxyphene; Drug Overdose; Ethanol; Fentanyl; Finland; Forensic Toxicology; Humans; Hypnotics and Sedatives; Methadone; Morphine; Opioid-Related Disorders; Oxycodone; Poisoning; Prescription Drug Misuse; Suicide; Tramadol; Young Adult | 2012 |
Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
Topics: Alprostadil; Biological Transport; Cadmium Chloride; Chloride Channels; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Lubiprostone; Methadone; Morphine; Naloxone; Patch-Clamp Techniques; Recombinant Proteins; Time Factors; Transfection | 2013 |
Unpredictable absorption of oral opioid medications in a quadriplegic patient with chronic enterocutaneous fistulas.
Topics: Administration, Oral; Analgesics, Opioid; Benzodiazepines; Biological Availability; Chronic Disease; Chronic Pain; Humans; Intestinal Fistula; Male; Methadone; Morphine; Oxycodone; Quadriplegia; Young Adult | 2012 |
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body | 2013 |
Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice.
Topics: Animals; Behavior, Animal; Buprenorphine; Drug Administration Schedule; Methadone; Mice; Morphine; Motor Activity; Narcotics | 2013 |
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord | 2013 |
The poor use of methadone in Italian hospices.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Data Collection; Home Care Services; Hospice Care; Hospices; Humans; Italy; Methadone; Morphine; Pain; Palliative Care; Practice Patterns, Physicians'; Terminally Ill | 2013 |
Development of sensitization to methamphetamine in offspring prenatally exposed to morphine, methadone and buprenorphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Central Nervous System Stimulants; Female; Male; Methadone; Methamphetamine; Models, Animal; Morphine; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reward; RNA, Messenger | 2014 |
Pharmacogenetics of opiates in clinical practice: the visible tip of the iceberg.
Topics: Analgesics, Opioid; Genetic Association Studies; Humans; Methadone; Morphine; Opioid Peptides; Pain Management; Pharmacogenetics; Receptors, Opioid; Receptors, Opioid, mu | 2013 |
Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Enkephalins; Male; Methadone; Morphine; Neostriatum; Nociceptin Receptor; Nucleus Accumbens; Pro-Opiomelanocortin; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Thalamus; Transcription, Genetic | 2013 |
Rotating to oral methadone in advanced cancer patients: a case series.
Topics: Adult; Aged; Analgesics, Opioid; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methadone; Morphine; Neuralgia; Pain, Intractable; Prostatic Neoplasms; Uterine Cervical Neoplasms | 2013 |
Dose ratios between high dose oral morphine or equivalents and oral methadone.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Hospice Care; Humans; Male; Medical Records; Methadone; Middle Aged; Morphine; New York; Pain Measurement; Pain, Intractable; Palliative Care; Retrospective Studies | 2013 |
Potential P-glycoprotein pharmacokinetic interaction of telaprevir with morphine or methadone.
Topics: Analgesics, Opioid; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Overdose; Humans; Methadone; Morphine; Oligopeptides | 2013 |
Methadone as an additional opioid for a cancer patient with severe neuropathic and bone pain not responsive to other opioids and adjuvant analgesics.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Drug Therapy, Combination; Humans; Lung Neoplasms; Methadone; Middle Aged; Morphine; Musculoskeletal Pain; Neuralgia; Palliative Care | 2013 |
Challenges of treating patients with chronic pain with dysphagia (CPD): physician and patient perspectives.
Topics: Analgesics, Opioid; Child; Chronic Pain; Data Collection; Deglutition Disorders; Fentanyl; Humans; Male; Medication Adherence; Methadone; Morphine; Palliative Care; Patient Medication Knowledge; Physicians; Treatment Outcome | 2014 |
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Breakthrough Pain; Constipation; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Nausea; Neoplasms; Pain Measurement; Retrospective Studies | 2014 |
Conditioned rewarding effects of morphine and methadone in mice pre-exposed to cocaine.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Motivation; Reward; Time Factors | 2013 |
[No opiates against cannabis hyperemesis syndrome].
Topics: Adult; Antiemetics; Dronabinol; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Germany; Humans; Infusions, Intravenous; Male; Marijuana Abuse; Methadone; Morphine; Opioid-Related Disorders; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Vomiting | 2014 |
What is your gut feeling about opioid rotation?
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Biological Availability; Delayed-Action Preparations; Drug Administration Schedule; Fentanyl; Humans; Hydromorphone; Intestinal Obstruction; Male; Methadone; Middle Aged; Morphine; Neoplasms; Pain; Pain Management; Quality of Life | 2015 |
A preliminary evaluation of the effects of opioids on innate and adaptive human in vitro immune function.
Topics: Adaptive Immunity; Adult; Analgesics, Opioid; Buprenorphine; Codeine; Fentanyl; Humans; Immunity, Innate; Interleukin-2; Interleukin-6; Leukocytes, Mononuclear; Methadone; Monocytes; Morphine; Neutrophils; Oxycodone; Phagocytosis; Respiratory Burst; Tramadol | 2014 |
Comprehensive automation of the solid phase extraction gas chromatographic mass spectrometric analysis (SPE-GC/MS) of opioids, cocaine, and metabolites from serum and other matrices.
Topics: Acetamides; Analgesics, Opioid; Automation; Cocaine; Codeine; Flunitrazepam; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Methadone; Morphine; Morphine Derivatives; Reproducibility of Results; Robotics; Solid Phase Extraction; Substance Abuse Detection; Trimethylsilyl Compounds | 2014 |
A study on photodegradation of methadone, EDDP, and other drugs of abuse in hair exposed to controlled UVB radiation.
Topics: Analgesics, Opioid; Cocaine; Hair; Humans; Methadone; Morphine; Morphine Derivatives; Photolysis; Pyrrolidines; Substance Abuse Detection; Ultraviolet Rays | 2014 |
Simultaneous determination of drugs of abuse and their main metabolites using pressurized liquid extraction and liquid chromatography-tandem mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Cocaine; Codeine; Methadone; Morphine; Reproducibility of Results; Sewage; Solvents; Spectrometry, Mass, Electrospray Ionization; Substance-Related Disorders; Tandem Mass Spectrometry; Temperature; Water Pollutants, Chemical | 2014 |
Assessment of CYP450 genetic variability effect on methadone dose and tolerance.
Topics: Adult; Alleles; Analgesics, Opioid; Biomarkers, Pharmacological; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Tolerance; Female; Heroin Dependence; Humans; International Normalized Ratio; Male; Methadone; Middle Aged; Morphine; Polymorphism, Single Nucleotide | 2014 |
Characteristics and quality of life of opioid-dependent pregnant women in Austria.
Topics: Administration, Oral; Adult; Austria; Buprenorphine; Delayed-Action Preparations; Female; Humans; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Pregnant Women; Quality of Life; Treatment Outcome | 2014 |
A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome.
Topics: Adult; Clinical Protocols; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intention to Treat Analysis; Length of Stay; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Phenobarbital; Treatment Outcome; Young Adult | 2014 |
Analysis of drugs of abuse in human plasma by dispersive liquid-liquid microextraction and high-performance liquid chromatography.
Topics: Analytic Sample Preparation Methods; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cocaine; Humans; Hydrogen-Ion Concentration; Illicit Drugs; Limit of Detection; Liquid Phase Microextraction; Methadone; Morphine; Morphine Derivatives; Opiate Substitution Treatment; Photometry; Reproducibility of Results; Solubility; Spectrophotometry, Ultraviolet; Substance Abuse Detection; Substance-Related Disorders; Ultrasonics | 2015 |
Multi-drug and metabolite quantification in postmortem blood by liquid chromatography-high-resolution mass spectrometry: comparison with nominal mass technology.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Chromatography, Liquid; Citalopram; Cocaine; Codeine; Dextromethorphan; Diphenhydramine; Evaluation Studies as Topic; Forensic Pathology; Humans; Hydrocodone; Hydromorphone; Meperidine; Methadone; Morphine; Oxycodone; Oxymorphone; Pyrrolidines; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry | 2014 |
Discriminative stimulus effects of the novel imidazoline I₂ receptor ligand CR4056 in rats.
Topics: Animals; Benzofurans; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Methadone; Morphine; Quinazolines; Rats | 2014 |
Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Behavior, Animal; Buprenorphine; Hyperalgesia; Ketamine; Male; Methadone; Methyl Ethers; Morphine; Nociception; Pain Threshold; Piperidines; Pulmonary Alveoli; Random Allocation; Rats, Wistar; Remifentanil; Sevoflurane | 2015 |
The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; California; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Methadone; Middle Aged; Morphine; Pain; Pain Management; Palliative Care; Retrospective Studies | 2015 |
Physiological and analgesic effects of continuous-rate infusion of morphine, butorphanol, tramadol or methadone in horses with lipopolysaccharide (LPS)-induced carpal synovitis.
Topics: Analgesia; Analgesics, Opioid; Animals; Butorphanol; Carpal Joints; Horse Diseases; Horses; Infusions, Intravenous; Lameness, Animal; Lipopolysaccharides; Methadone; Morphine; Synovitis; Tramadol | 2014 |
Comparing treatment-seeking codeine users and strong opioid users: Findings from a novel case series.
Topics: Adult; Codeine; Female; Humans; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Oxycodone; Patient Acceptance of Health Care; Retrospective Studies | 2015 |
Application of drug testing using exhaled breath for compliance monitoring of drug addicts in treatment.
Topics: Adolescent; Adult; Aged; Amphetamines; Breath Tests; Buprenorphine; Cocaine; Drug Users; Exhalation; Female; Humans; Male; Methadone; Methamphetamine; Middle Aged; Morphine; Morphine Derivatives; Patient Compliance; Substance Abuse Detection; Young Adult | 2015 |
Out-of-hospital mortality among patients receiving methadone for noncancer pain.
Topics: Adult; Aged; Cohort Studies; Death, Sudden; Delayed-Action Preparations; Female; Humans; Male; Methadone; Middle Aged; Morphine; Pain Management; Retrospective Studies | 2015 |
Opiate addiction therapies and HIV-1 Tat: interactive effects on glial [Ca²⁺]i, oxyradical and neuroinflammatory chemokine production and correlative neurotoxicity.
Topics: Buprenorphine; Calcium; Cell Survival; Cells, Cultured; Chemokines; Humans; Methadone; Morphine; Narcotic Antagonists; Narcotics; Neuroglia; Neurons; Reactive Oxygen Species; tat Gene Products, Human Immunodeficiency Virus | 2014 |
Quantification of morphine, morphine 6-glucuronide, buprenorphine, and the enantiomers of methadone by enantioselective mass spectrometric chromatography in whole blood.
Topics: Buprenorphine; Chromatography, Liquid; Forensic Toxicology; Humans; Mass Spectrometry; Methadone; Molecular Structure; Morphine; Morphine Derivatives; Narcotics; Solid Phase Extraction; Stereoisomerism; Substance-Related Disorders | 2015 |
Data triangulation in the context of opioids monitoring via wastewater analyses.
Topics: Adult; Analgesics, Opioid; Drug Residues; Female; Heroin; Humans; Illicit Drugs; Male; Methadone; Monte Carlo Method; Morphine; Needle-Exchange Programs; Opiate Substitution Treatment; Registries; Substance-Related Disorders; Switzerland; Wastewater | 2015 |
Does therapeutic use of tapentadol cause false-positive urine screens for methadone or opiates?
Topics: Adult; Aged, 80 and over; Analgesics, Opioid; Chromatography, Gas; Chromatography, Liquid; False Positive Reactions; Female; Humans; Hydrocodone; Immunoenzyme Techniques; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Oxycodone; Phenols; Predictive Value of Tests; Reproducibility of Results; Substance Abuse Detection; Tandem Mass Spectrometry; Tapentadol; Urinalysis | 2015 |
Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.
Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Infant; Infant, Newborn; Medicaid; Methadone; Middle Aged; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pain; Practice Patterns, Physicians'; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Prescriptions; Risk Factors; Smoking; United States | 2015 |
Chemokine IP-10 is correlated with cardiac responses and status of infection with HIV and HCV in methadone maintenance patients.
Topics: Adult; Chemokine CXCL10; Chemokines; Electrocardiography; Female; Hepatitis C; Heroin Dependence; HIV Infections; Humans; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Tachycardia; Tumor Necrosis Factor-alpha; Young Adult | 2015 |
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
Topics: Alternative Splicing; Analgesics, Opioid; Animals; Exons; Gene Targeting; Methadone; Mice; Mice, Knockout; Morphine; Naltrexone; Pain; Peptide Fragments; Protein Structure, Tertiary; Receptors, Opioid, mu; Recombinant Proteins | 2015 |
Opioid Overdose Deaths in the City and County of San Francisco: Prevalence, Distribution, and Disparities.
Topics: Adolescent; Adult; Aged; Black or African American; Cocaine; Drug Overdose; Female; Health Status Disparities; Humans; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Oxycodone; Poverty Areas; Prevalence; San Francisco; Socioeconomic Factors; Young Adult | 2015 |
Use of Very-Low-Dose Methadone and Haloperidol for Pain Control in Palliative Care Patients: Are the Sigma-1 Receptors Involved?
Topics: Analgesics, Opioid; Female; Haloperidol; Humans; Male; Methadone; Morphine; Pain; Pain Management; Palliative Care | 2015 |
Contrasting cardiovascular properties of the µ-opioid agonists morphine and methadone in the rat.
Topics: Animals; Arterial Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cardiovascular System; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Histamine H2 Antagonists; Mesenteric Arteries; Methadone; Morphine; Rats; Receptors, Opioid, mu | 2015 |
Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine.
Topics: Analgesics, Opioid; Animals; Brain; Buprenorphine; Central Nervous System Depressants; Corticosterone; Dose-Response Relationship, Drug; Drug Tolerance; Ethanol; Exploratory Behavior; Hot Temperature; Male; Methadone; Mice; Morphine; Motor Activity; Nociceptive Pain; Pain Threshold; Plethysmography; Respiration; Respiratory System Agents; Tidal Volume | 2016 |
Illicit Heroin and Methamphetamine Use among Methadone Maintenance Treatment Patients in Dehong Prefecture of Yunnan Province, China.
Topics: Adolescent; Adult; Aged; Amphetamine-Related Disorders; Analgesics, Opioid; China; Cross-Sectional Studies; Data Collection; Drug Users; Female; Heroin Dependence; Humans; Logistic Models; Male; Methadone; Methamphetamine; Middle Aged; Morphine; Multivariate Analysis; Opiate Substitution Treatment; Substance Abuse Detection; Young Adult | 2015 |
Implementation of a Neonatal Abstinence Syndrome Weaning Protocol: A Multicenter Cohort Study.
Topics: Adult; Analgesics, Opioid; Clinical Protocols; Cohort Studies; Female; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Retrospective Studies | 2015 |
Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment.
Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Endocytosis; Male; Methadone; Mice; Morphine; Pain Measurement; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2016 |
Sustained release oral morphine as an alternative to methadone for the treatment of opioid-use disorder post Torsades de Pointes cardiac arrest.
Topics: Administration, Oral; Delayed-Action Preparations; Electrocardiography; Heart Arrest; Humans; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Torsades de Pointes | 2015 |
Neonatal abstinence syndrome: use of clonazepam?
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Male; Methadone; Morphine; Neonatal Abstinence Syndrome | 2015 |
Reply to 'Methadone versus morphine for treatment of neonatal abstinence syndrome: a prospective randomized clinical trial'.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Male; Methadone; Morphine; Neonatal Abstinence Syndrome | 2015 |
Fatal poisoning among patients with drug addiction.
Topics: Adolescent; Adult; Age Distribution; Analgesics, Opioid; Cause of Death; Denmark; Female; Forensic Medicine; Humans; Male; Methadone; Middle Aged; Morphine; Sex Distribution; Substance-Related Disorders; Young Adult | 2015 |
Long-Acting Opioids for Treating Neonatal Abstinence Syndrome: A High Price for a Short Stay?
Topics: Analgesics, Opioid; Half-Life; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Ondansetron; Serotonin Antagonists | 2015 |
Understanding Heroin Overdose: A Study of the Acute Respiratory Depressant Effects of Injected Pharmaceutical Heroin.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Capnography; Drug Overdose; Electromyography; Female; Heroin; Heroin Dependence; Humans; Hypoventilation; Injections, Intramuscular; Male; Methadone; Middle Aged; Morphine; Oximetry; Pulmonary Disease, Chronic Obstructive | 2015 |
Retrospective chart review comparing morphine and methadone in neonates treated for neonatal abstinence syndrome.
Topics: Administration, Oral; Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Retrospective Studies; Treatment Outcome | 2015 |
Neonatal withdrawal syndrome and perinatal asphyxia. How to manage the patient? Case Report.
Topics: Asphyxia Neonatorum; Disease Management; Humans; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opiate Substitution Treatment | 2015 |
Impact of blended treatment literacy and psychoeducation on methadone maintenance treatment outcomes in Yunnan, China.
Topics: Adult; China; Combined Modality Therapy; Female; Heroin Dependence; Humans; Male; Medication Adherence; Methadone; Middle Aged; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Patient Education as Topic; Peer Group; Physicians; Treatment Outcome; Young Adult | 2016 |
Expression levels of OPRM1 and PDYN in human SH-SY5Y cells treated with morphine and methadone.
Topics: Analgesics, Opioid; Cell Line; Dose-Response Relationship, Drug; Enkephalins; Humans; Methadone; Morphine; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger | 2016 |
The ABCB1, rs9282564, AG and TT Genotypes and the COMT, rs4680, AA Genotype are Less Frequent in Deceased Patients with Opioid Addiction than in Living Patients with Opioid Addiction.
Topics: Adolescent; Adult; Aged; ATP Binding Cassette Transporter, Subfamily B; Catechol O-Methyltransferase; Cohort Studies; Death, Sudden; Denmark; Female; Genetic Association Studies; Heterozygote; Homozygote; Humans; Male; Methadone; Middle Aged; Morphine; Morphine Dependence; Narcotics; Polymorphism, Single Nucleotide; Young Adult | 2016 |
The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland.
Topics: Animals; Arginine Vasopressin; Circadian Rhythm; In Situ Hybridization; Male; Methadone; Morphine; Narcotics; Period Circadian Proteins; Rats, Wistar; Substance Withdrawal Syndrome; Suprachiasmatic Nucleus | 2016 |
NICE calls for safer use of controlled drugs.
Topics: Analgesics, Opioid; Benzodiazepines; Controlled Substances; Diazepam; Drug Storage; Humans; Methadone; Morphine; Patient Education as Topic | 2016 |
Effect of breastfeeding on neonatal abstinence syndrome.
Topics: Breast Feeding; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome | 2016 |
Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain.
Topics: Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Cardiovascular Diseases; Cause of Death; Chronic Pain; Drug Overdose; Drug Prescriptions; Female; Fentanyl; Humans; Male; Methadone; Middle Aged; Morphine; Oxycodone; Propensity Score; Proportional Hazards Models; Retrospective Studies; Risk | 2016 |
Popliteal Vein Blood Sampling and the Postmortem Redistribution of Diazepam, Methadone, and Morphine.
Topics: Diazepam; Forensic Toxicology; Humans; Methadone; Morphine; Popliteal Vein; Postmortem Changes | 2016 |
Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS).
Topics: Amides; Analgesics; Anesthetics; Baclofen; Bupivacaine; Caffeine; Chromatography, High Pressure Liquid; Clonidine; Dexamethasone; Ephedrine; Fentanyl; Heparin; Hydromorphone; Ketamine; Mass Spectrometry; Methadone; Midazolam; Morphine; Oxytocin; Parenteral Nutrition Solutions; Phenylephrine; Ropivacaine; Succinylcholine | 2016 |
Evaluation of the vaginal flora in pregnant women receiving opioid maintenance therapy: a matched case-control study.
Topics: Adult; Analgesics, Opioid; Asymptomatic Infections; Austria; Birth Weight; Buprenorphine; Candidiasis, Vulvovaginal; Case-Control Studies; Female; Gestational Age; Humans; Infant, Newborn; Maintenance Chemotherapy; Methadone; Morphine; Opioid-Related Disorders; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; Trichomonas Vaginitis; Vagina; Vaginosis, Bacterial; Young Adult | 2016 |
Neonatal Abstinence Syndrome: Twelve Years of Experience at a Regional Referral Center.
Topics: Buprenorphine; Diseases in Twins; Female; Hospitalization; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Pregnancy; Referral and Consultation; Retrospective Studies; Substance Abuse Treatment Centers; Treatment Outcome | 2017 |
Growth hormone is protective against acute methadone-induced toxicity by modulating the NMDA receptor complex.
Topics: Animals; Caspase 3; Caspase 7; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Human Growth Hormone; L-Lactate Dehydrogenase; Methadone; Mitochondria; Morphine; Naloxone; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger | 2016 |
Postmortem Concentration and Redistribution of Diazepam, Methadone, and Morphine with Subclavian and Femoral Vein Dissection/Clamping.
Topics: Constriction; Diazepam; Femoral Vein; Humans; Methadone; Morphine; Postmortem Changes | 2016 |
The relationship between gestational age and the severity of neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Length of Stay; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Ohio; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Premature Birth; Retrospective Studies; Severity of Illness Index; Term Birth; Time Factors; Young Adult | 2017 |
Site-, Technique-, and Time-Related Aspects of the Postmortem Redistribution of Diazepam, Methadone, Morphine, and their Metabolites: Interest of Popliteal Vein Blood Sampling.
Topics: Adult; Blood Specimen Collection; Chromatography, Liquid; Diazepam; Female; Femoral Vein; Forensic Toxicology; Humans; Male; Methadone; Middle Aged; Morphine; Morphine Derivatives; Nordazepam; Oxazepam; Popliteal Vein; Postmortem Changes; Subclavian Vein; Young Adult | 2017 |
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.
Topics: Adult; Alleles; Analgesics, Opioid; Black or African American; Dose-Response Relationship, Drug; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Pain; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; United States; White People | 2017 |
Evaluation of an Automated Reader and Color Interpretation-Based Immunoassays for Multiplexed Drug-of-Abuse Testing in Urine.
Topics: Amphetamine; Automation; Buprenorphine; China; Cocaine; Dronabinol; Gas Chromatography-Mass Spectrometry; Illicit Drugs; Immunoassay; Mass Spectrometry; Methadone; Methamphetamine; Morphine; Sensitivity and Specificity; Substance Abuse Detection | 2017 |
Commentary on Gibson et al. (2017): Gestational age and the severity of neonatal abstinence syndrome.
Topics: Buprenorphine; Gestational Age; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy Complications | 2017 |
Comparison Between Urinalysis Results and Self-Reported Heroin Use Among Patients Undergoing Methadone Maintenance Treatment in China.
Topics: Adult; China; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Reproducibility of Results; Self Efficacy; Self Report; Substance Abuse Detection; Young Adult | 2017 |
Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome.
Topics: ADAM10 Protein; Adult; Amyloid Precursor Protein Secretases; Antigens, CD; Cadherins; Female; Heroin; Heroin Dependence; HIV Infections; Humans; Interleukin-7; Male; Membrane Proteins; Methadone; Morphine; Pharmacogenetics; Polymorphism, Single Nucleotide; Treatment Outcome; Vitamin D | 2017 |
Sex Differences in Regional Brain Glucose Metabolism Following Opioid Withdrawal and Replacement.
Topics: Analgesics, Opioid; Animals; Brain; Brain Mapping; Buprenorphine; Cross-Sectional Studies; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Glucose; Longitudinal Studies; Male; Methadone; Morphine; Morphine Dependence; Positron-Emission Tomography; Radiopharmaceuticals; Rats, Sprague-Dawley; Sex Characteristics; Treatment Outcome | 2017 |
An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome.
Topics: Female; Hospital Costs; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Pregnancy; Prenatal Exposure Delayed Effects; Quality Indicators, Health Care; Quality of Health Care | 2017 |
Chemical stability of morphine and methadone, and of methadone in combination with acepromazine, medetomidine or xylazine, during prolonged storage in syringes.
Topics: Acepromazine; Animals; Drug Stability; Drug Storage; Medetomidine; Methadone; Morphine; Syringes; Xylazine | 2017 |
The Effect of Morphine Dosing on Length of Stay in Neonatal Abstinence Syndrome - An Alternative Viewpoint.
Topics: Hospitals, Community; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome | 2017 |
Comparison of Neonatal Abstinence Syndrome Treatment with Sublingual Buprenorphine versus Conventional Opioids.
Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Retrospective Studies; Time Factors | 2018 |
Interpretation of Urine Drug Screens: Metabolites and Impurities.
Topics: Analgesics, Opioid; Codeine; False Positive Reactions; Female; Humans; Hydromorphone; Immunoassay; Mass Spectrometry; Methadone; Middle Aged; Morphine; Substance Abuse Detection | 2017 |
Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine.
Topics: Adult; Chemokine CXCL10; Claudins; Female; Humans; Male; Methadone; Morphine; Mutation, Missense; Opiate Substitution Treatment; Substance Abuse Detection | 2017 |
APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amphetamine-Related Disorders; Amyloid beta-Peptides; Biomarkers; Cells, Cultured; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Interferon-gamma; Lymphocytes; Male; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Peptide Fragments; Polymorphism, Single Nucleotide; Promoter Regions, Genetic | 2018 |
Patterns of regional variation of opioid prescribing in primary care in England: a retrospective observational study.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Pain; Crime; Databases, Factual; Education; Employment; England; Health Status; Housing; Humans; Income; Methadone; Morphine; Oxycodone; Practice Patterns, Physicians'; Primary Health Care; Residence Characteristics; Retrospective Studies; Socioeconomic Factors; Tramadol | 2018 |
Disulfiram attenuates morphine or methadone withdrawal syndrome in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disulfiram; Male; Methadone; Mice; Mice, Inbred C57BL; Models, Animal; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2018 |
Effects of dexmedetomidine combined with commonly administered opioids on clinical variables in dogs.
Topics: Analgesics, Opioid; Animals; Butorphanol; Dexmedetomidine; Dogs; Drug Combinations; Female; Heart Rate; Male; Methadone; Morphine; Respiratory Rate; Tramadol | 2018 |
Buprenorphine Maintenance Subjects Are Hyperalgesic and Have No Antinociceptive Response to a Very High Morphine Dose.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Tolerance; Female; Humans; Hyperalgesia; Injections, Intravenous; Male; Methadone; Morphine; Opiate Substitution Treatment; Pain Measurement; Pain Threshold; Young Adult | 2019 |
The effect of standardizing treatment when managing neonatal abstinence syndrome
Topics: Adolescent; Adult; Analgesics, Opioid; Clinical Protocols; Comorbidity; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Reference Standards; Treatment Outcome; Young Adult | 2019 |
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment.
Topics: Animals; Anxiety; Depression; Exercise Test; Male; Maze Learning; Methadone; Morphine; Morphine Dependence; Opiate Substitution Treatment; Physical Conditioning, Animal; Rats; Self Administration; Severity of Illness Index; Substance Withdrawal Syndrome | 2018 |
Effects of treadmill exercise on methadone withdrawal-induced locomotor sensitization and the ventral pallidum and ventral tegmental area BDNF levels in morphine withdrawn rats receiving methadone maintenance treatment.
Topics: Analgesics, Opioid; Animals; Basal Forebrain; Brain-Derived Neurotrophic Factor; Exercise Test; Locomotion; Male; Methadone; Morphine; Morphine Dependence; Opiate Substitution Treatment; Rats; Rats, Sprague-Dawley; Rats, Wistar; Treatment Outcome; Ventral Tegmental Area | 2018 |
Profile, risk practices and needs of people who inject morphine sulfate: Results from the ANRS-AERLI study.
Topics: Adult; Buprenorphine; Female; France; Humans; Longitudinal Studies; Male; Methadone; Morphine; Narcotics; Needs Assessment; Opiate Substitution Treatment; Substance Abuse, Intravenous | 2018 |
In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway.
Topics: AMP-Activated Protein Kinase Kinases; Analgesics, Opioid; Animals; Cell Line, Tumor; Cyclic AMP; Drug Tolerance; Eukaryotic Initiation Factors; Glioblastoma; Humans; Metformin; Methadone; Morphine; Opioid-Related Disorders; Phosphorylation; Protein Kinases; Pyrazoles; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
One size does not fit all-evolution of opioid agonist treatments in a naturalistic setting over 23 years.
Topics: Adult; Age Factors; Analgesics, Opioid; Buprenorphine; Employment; Family Relations; Female; Friends; Heroin; Housing; Humans; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Social Integration; Social Participation; Substance Abuse, Intravenous; Switzerland | 2019 |
Morphine vs Methadone Treatment for Infants with Neonatal Abstinence Syndrome.
Topics: Cohort Studies; Databases, Factual; Female; Follow-Up Studies; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Length of Stay; Male; Methadone; Morphine; Multivariate Analysis; Neonatal Abstinence Syndrome; Propensity Score; Retrospective Studies; Risk Assessment; Treatment Outcome; United States | 2018 |
Long-acting Opioid Use and the Risk of Serious Infections: A Retrospective Cohort Study.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Female; Fentanyl; Hospitalization; Humans; Immunosuppressive Agents; Infections; Male; Medicaid; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Retrospective Studies; Risk Factors; Tennessee; United States | 2019 |
Evaluation of an on-site test device for the heroin metabolite 6-acetylmorphine in urine.
Topics: Buprenorphine; Codeine; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Methadone; Morphine; Morphine Derivatives; Reagent Strips; Sensitivity and Specificity; Substance Abuse Detection | 2019 |
Morphine, but not methadone, inhibits microsomal prostaglandin E synthase-1 and prostaglandin-endoperoxide synthase 2 in lipopolysaccharide-stimulated horse synoviocytes.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Horses; Inflammation; Lipopolysaccharides; Male; Methadone; Microsomes; Morphine; Prostaglandin-E Synthases; Synoviocytes | 2019 |
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Anesthesia; Buprenorphine; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Fluoresceins; Humans; Immunosuppression Therapy; K562 Cells; Killer Cells, Natural; Loperamide; Methadone; Morphinans; Morphine; Naloxone; Naltrexone; Succinimides; Toll-Like Receptor 4; Tramadol | 2019 |
Role of agonist efficacy in exposure-induced enhancement of mu opioid reward in rats.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Dose-Response Relationship, Drug; Fentanyl; Male; Methadone; Morphine; Nalbuphine; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Reward; Self Stimulation | 2019 |
Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids.
Topics: Analgesics, Opioid; Animals; Cell Line; Humans; Male; Methadone; Morphine; Protein Multimerization; Rats; Rats, Sprague-Dawley; Receptor, Galanin, Type 1; Receptors, Opioid, mu | 2019 |
Morphine infusor pump switch to oral methadone.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; Drug Substitution; Fatal Outcome; Female; Humans; Infusion Pumps; Infusions, Subcutaneous; Male; Methadone; Middle Aged; Morphine; Palliative Care; Spain | 2020 |
Current Status of Adverse Events Related with Opioid Analgesics in Japan: Assessment Based on Japanese Adverse Drug Event Report Database.
Topics: Adverse Drug Reaction Reporting Systems; Analgesics, Opioid; Databases, Factual; Fentanyl; Humans; Japan; Methadone; Morphine; Oxycodone; Tapentadol | 2019 |
Concomitant Heroin and Cocaine Use among Opioid-Dependent Patients during Methadone, Buprenorphine or Morphine Opioid Agonist Therapy.
Topics: Adult; Analgesics, Opioid; Behavior, Addictive; Buprenorphine; Cocaine; Cross-Sectional Studies; Delayed-Action Preparations; Female; Heroin; Humans; Male; Methadone; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Switzerland | 2019 |
Placental trophoblast transfer of opioids following exposures to individual or mixtures of opioids
Topics: Analgesics, Opioid; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Heroin; Humans; Maternal-Fetal Exchange; Methadone; Morphine; Naloxone; Oxycodone; Placenta; Pregnancy; Trophoblasts | 2019 |
Opioid-galanin receptor heteromers differentiate the dopaminergic effects of morphine and methadone.
Topics: Analgesics, Opioid; Animals; Dopamine Agents; Galanin; Methadone; Morphine; Rats; Receptors, Galanin; Receptors, Opioid; Receptors, Opioid, mu | 2019 |
Morphine vs methadone in the treatment of neonatal abstinence syndrome.
Topics: Humans; Infant, Newborn; Methadone; Morphine; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders | 2019 |
Interventions for the Treatment of Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Pregnancy; Pregnancy Complications; Treatment Outcome | 2019 |
Opioid receptor-mediated changes in the NMDA receptor in developing rat and chicken.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cerebellum; Chickens; Female; Methadone; Morphine; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2019 |
Risk assessment of using off-label morphine sulfate in a population-based retrospective cohort of opioid-dependent patients.
Topics: Analgesics, Opioid; Buprenorphine; Delivery of Health Care; Humans; Male; Methadone; Morphine; Off-Label Use; Opiate Substitution Treatment; Opioid-Related Disorders; Retrospective Studies; Risk Assessment | 2020 |
Management of Newborns with Prenatal Opioid Exposure: One Institution's Journey.
Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Outpatients; Parents; Pregnancy; Quality Improvement | 2019 |
Correlation between interleukin-6 levels and methadone maintenance therapy outcomes.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Transforming Growth Factor beta1; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2019 |
The place of methadone in the Game of the Goose for postoperative pain.
Topics: Analgesics, Opioid; Animals; Geese; Humans; Methadone; Morphine; Pain, Postoperative | 2019 |
Comparison of pre-pulse inhibition, tactile discrimination learning and barrel cortical neural response in adult male rats following chronic exposure to morphine, methadone and buprenorphine.
Topics: Animals; Auditory Perception; Buprenorphine; Cerebral Cortex; Discrimination Learning; Male; Methadone; Morphine; Neurons; Prepulse Inhibition; Rats; Stereotyped Behavior; Touch Perception | 2019 |
Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids.
Topics: Adolescent; Adult; Analgesics, Opioid; Australia; Chronic Pain; Drug Overdose; Drug Prescriptions; Female; Fentanyl; Heroin; Humans; Male; Methadone; Middle Aged; Morphine; Naloxone; Opioid-Related Disorders; Tramadol; Young Adult | 2019 |
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze Learning; Methadone; Morphine; Narcotics; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Seizures; Sex Factors; Tramadol | 2020 |
Neonatal Abstinence Syndrome.
Topics: History, 19th Century; History, 20th Century; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; United States | 2020 |
Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Anticonvulsants; Dried Blood Spot Testing; Female; Humans; Infant, Newborn; Labor, Obstetric; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Pyrrolidines | 2021 |
Emerging therapies for the treatment of neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy | 2022 |
The impact of the prescription opioid epidemic on young children: Trends and mortality.
Topics: Analgesics, Opioid; Buprenorphine; Child, Preschool; Epidemics; Female; Fentanyl; Humans; Infant; Male; Methadone; Morphine; Opioid Epidemic; Oxycodone; Poison Control Centers; Prescription Drugs | 2020 |
Enriched Environment Ameliorates Cognitive Deficits and Locomotor Sensitization in Morphine-Withdrawn Rats Receiving Methadone Maintenance Treatment.
Topics: Animals; Cognitive Dysfunction; Locomotion; Male; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Rats; Rats, Wistar; Recognition, Psychology; Spatial Learning; Substance Withdrawal Syndrome | 2020 |
Methadone rotation for cancer pain: an observational study.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Neuralgia | 2022 |
Postmortem metabolomics: Correlating time-dependent concentration changes of xenobiotic and endogenous compounds.
Topics: Adult; Aged; Autopsy; Chromatography, Liquid; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Male; Metabolomics; Methadone; Middle Aged; Morphine; Postmortem Changes; Reproducibility of Results; Time Factors; Xenobiotics; Young Adult | 2020 |
Clonidine versus phenobarbital as adjunctive therapy for neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Clonidine; Humans; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Prospective Studies | 2020 |
Switching opioid-dependent patients in substitution treatment from racemic methadone, levomethadone and buprenorphine to slow-release oral morphine: Analysis of the switching process in routine care.
Topics: Administration, Oral; Adult; Buprenorphine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Substitution; Female; Humans; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Treatment Outcome; Young Adult | 2020 |
Effects of polysubstance exposure on neonatal outcomes for infants with intrauterine opioid exposure.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregnancy; Retrospective Studies | 2020 |
Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse.
Topics: Analgesics, Opioid; Ascorbic Acid; Dehydroascorbic Acid; Enkephalin, Methionine; Glutathione; Humans; Hydromorphone; Methadone; Morphine; Naloxone; Peptides; Receptors, Adrenergic, beta-2; Receptors, Dopamine D1; Receptors, Histamine H1; Receptors, Opioid; Receptors, Opioid, mu | 2020 |
Revealing the Kinetic Advantage of a Competitive Small-Molecule Immunoassay by Direct Detection.
Topics: Antibodies; Binding, Competitive; Cocaine; Immunoassay; Kinetics; Methadone; Morphine; Small Molecule Libraries | 2020 |
Lithium reverses the effect of opioids on eNOS/nitric oxide pathway in human umbilical vein endothelial cells.
Topics: Analgesics, Opioid; Cell Survival; Cyclic AMP; Drug Tolerance; Glycogen Synthase Kinase 3 beta; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Lithium Chloride; Methadone; Morphine; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Signal Transduction | 2020 |
Orchestrated Testing of Formula Type to Reduce Length of Stay in Neonatal Abstinence Syndrome.
Topics: Energy Intake; Female; Humans; Infant Formula; Infant, Newborn; Lactose; Length of Stay; Methadone; Morphine; Neonatal Abstinence Syndrome; Ohio; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Quality Improvement; Weight Gain | 2020 |
Aspiration in lethal drug abuse-a consequence of opioid intoxication.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Austria; Autopsy; Cause of Death; Female; Forensic Toxicology; Heroin; Humans; Male; Methadone; Middle Aged; Morphine; Respiratory Aspiration of Gastric Contents; Retrospective Studies; Substance-Related Disorders; Young Adult | 2020 |
Model-Based Approach to Improve Clinical Outcomes in Neonates With Opioid Withdrawal Syndrome Using Real-World Data.
Topics: Analgesics, Opioid; Electronic Health Records; Female; Hospitalization; Humans; Infant, Newborn; Length of Stay; Longitudinal Studies; Male; Methadone; Morphine; Retrospective Studies; Substance Withdrawal Syndrome | 2021 |
Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent.
Topics: Analgesics, Opioid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Glioblastoma; Humans; Methadone; Morphine; Naloxone; Oxycodone; Receptors, Opioid, mu; Tumor Cells, Cultured | 2021 |
Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome?
Topics: Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Phenobarbital; Pregnancy; Retrospective Studies | 2022 |
The effects of morphine, methadone, and fentanyl on mitochondria: A live cell imaging study.
Topics: Animals; Cell Line, Tumor; Fentanyl; Methadone; Mice; Mitochondria; Morphine; Narcotics; Rats; Time-Lapse Imaging | 2021 |
Is it time to replace morphine with methadone for the treatment of pain in the neonatal intensive care unit?
Topics: Analgesics, Opioid; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Methadone; Morphine; Pain Management | 2021 |
Substitution treatment for opioid dependence with slow-release oral morphine: Retention rate, health status, and substance use after switching to morphine.
Topics: Adult; Analgesics, Opioid; Delayed-Action Preparations; Germany; Health Status; Humans; Male; Methadone; Morphine; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Prospective Studies; Treatment Outcome | 2021 |
Dental Plaque Concentrations of Methadone, Morphine and Their Metabolites in Opioid Replacement Therapy and in Postmortem Cases.
Topics: Dental Plaque; Humans; Methadone; Morphine; Opiate Substitution Treatment; Pyrrolidines; Substance-Related Disorders | 2022 |
Hydromorphone and codeine concentrations in oral fluid specimens from patients receiving substitution therapy with Substitol™ (morphine sulfate).
Topics: Adult; Aged; Aged, 80 and over; Buprenorphine; Codeine; Female; Humans; Hydromorphone; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Saliva; Substance Abuse Detection | 2021 |
Uptake of slow-release oral morphine as opioid agonist treatment among hospitalised patients with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders | 2022 |
Buprenorphine Increases HIV-1 Infection In Vitro but Does Not Reactivate HIV-1 from Latency.
Topics: Buprenorphine; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Methadone; Morphine; Nociceptin Receptor; Receptors, Opioid; Virus Activation; Virus Latency; Virus Replication | 2021 |
Declines and regional variation in opioid distribution by U.S. hospitals.
Topics: Analgesics, Opioid; Buprenorphine; Codeine; Hospitals; Humans; Hydromorphone; Meperidine; Methadone; Morphine; Oxymorphone; United States | 2022 |
Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers.
Topics: Analgesics, Opioid; Animals; Apoptosis; Biomarkers; Cell Line; Cyclic AMP; Glial Cell Line-Derived Neurotrophic Factor; Inflammation; Male; Methadone; Mice; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxidative Stress; Oxidoreductases; Proto-Oncogene Proteins c-bcl-2; Sertoli Cells; Substance Withdrawal Syndrome | 2021 |
Effect of Methadone Maintenance on Expression of BDNF and CREB Genes in Brain VTA of Male Morphine Treated Rats.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Male; Methadone; Morphine; Rats; Rats, Wistar | 2021 |
Opioid Weaning Protocol Using Morphine Compared With Nonprotocolized Methadone Associated With Decreased Dose and Duration of Opioid After Norwood Procedure.
Topics: Analgesics, Opioid; Child; Humans; Infant, Newborn; Methadone; Morphine; Norwood Procedures; Substance Withdrawal Syndrome | 2022 |
Morphine to methadone, and beyond.
Topics: Humans; Methadone; Morphine | 2022 |
Intraoperative Methadone Use in Pediatric Burn Patients.
Topics: Adult; Analgesics, Opioid; Burns; Child; Humans; Methadone; Morphine; Pain; Retrospective Studies | 2022 |
Neonatal Opioid Withdrawal Syndrome: A Comparison of As-Needed Pharmacotherapy.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Pregnancy; Retrospective Studies | 2022 |
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neuroblastoma | 2022 |
Simultaneous electrochemical determination of morphine and methadone by using CMK-5 mesoporous carbon and multivariate calibration.
Topics: Calibration; Carbon; Electrochemical Techniques; Electrodes; Limit of Detection; Methadone; Morphine | 2022 |
REL-1017 (esmethadone; D-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats.
Topics: Animals; Ketamine; Methadone; Morphine; Oxycodone; Rats; Rats, Sprague-Dawley; Substance-Related Disorders | 2022 |
Common opioids and stimulants in autopsy and DUID cases: A comparison of measured concentrations.
Topics: Amphetamine; Analgesics, Opioid; Autopsy; Central Nervous System Stimulants; Cocaine; Coma; Heroin; Humans; Methadone; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Substance Abuse Detection; Substance-Related Disorders | 2022 |
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Morphine; Neonatal Abstinence Syndrome; Oxycodone; Pain; Pregnancy; Prescriptions; Substance Withdrawal Syndrome; Tramadol; United States | 2022 |
Combined effects of quetiapine and opioids: A study of autopsy cases, drug users and sedation in rats.
Topics: Analgesics, Opioid; Animals; Autopsy; Drug Users; Humans; Hypnotics and Sedatives; Methadone; Morphine; Quetiapine Fumarate; Rats | 2022 |
Opioid replacement therapy with methadone or buprenorphine effects on male mice reproduction.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Chromatin; Male; Methadone; Mice; Morphine; Morphine Dependence; Opiate Substitution Treatment; Opioid-Related Disorders; Reproduction; Semen; Semen Analysis | 2023 |
Commentary on Nikoo et al.: Challenges in protocol development to optimize outcomes of opium tincture maintenance treatment.
Topics: Humans; Methadone; Morphine; Opium; Research Design | 2023 |
Letter-to-the-editor, concerning the article entitled "Common opioids and stimulants in autopsy and DUID cases: A comparison of measured concentrations."
Topics: Amphetamine; Analgesics, Opioid; Autopsy; Central Nervous System Stimulants; Cocaine; Methadone; Morphine; Substance Abuse Detection | 2023 |
Single-Center Retrospective Comparison of Opioid-Based and Multimodal Analgesic Regimens in Adult Cardiac Surgery.
Topics: Adult; Analgesics; Analgesics, Opioid; Cardiac Surgical Procedures; Dexmedetomidine; Humans; Methadone; Morphine; Opioid-Related Disorders; Pain, Postoperative; Postoperative Nausea and Vomiting; Retrospective Studies | 2023 |
Validation of an HPLC-HR-MS Method for the Determination and Quantification of Six Drugs (Morphine, Codeine, Methadone, Alprazolam, Clonazepam and Quetiapine) in Nails.
Topics: Alprazolam; Benzodiazepines; Chromatography, High Pressure Liquid; Clonazepam; Codeine; Humans; Methadone; Morphine; Nails; Quetiapine Fumarate | 2023 |
Rescue Analgesia for Opioid-Dependent Individuals on Opioid Agonist Treatment during Hospitalization: Adherence to Guideline Treatment.
Topics: Adult; Analgesics; Analgesics, Opioid; Female; Hospitalization; Humans; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Opioid-Related Disorders; Pain; Pain Management | 2023 |
Detection of Three Opioids (Morphine, Codeine and Methadone) and Their Metabolites (6-Monoacetylmorphine and 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) in Larvae of
Topics: Analgesics, Opioid; Animals; Chromatography, High Pressure Liquid; Codeine; Diptera; Humans; Larva; Methadone; Morphine; Morphine Derivatives | 2023 |
Assessing the impact of the slow-release oral morphine drug shortages in Ontario, Canada: A population-based time series analysis.
Topics: Administration, Oral; Analgesics, Opioid; Delayed-Action Preparations; Female; Humans; Male; Methadone; Morphine; Ontario; Opiate Substitution Treatment; Opioid-Related Disorders; Pain; Retrospective Studies; Time Factors | 2023 |
Comparison of oral versus intravenous methadone on postoperative pain and opioid use after adult spinal deformity surgery: A retrospective, non-inferiority analysis.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Humans; Long QT Syndrome; Methadone; Morphine; Opioid-Related Disorders; Pain, Postoperative; Retrospective Studies | 2023 |
Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.
Topics: Analgesics, Opioid; Animals; HEK293 Cells; Humans; Male; Methadone; Mice; Morphine; Oxycodone; Respiratory Insufficiency | 2023 |
Shift in hospital opioid use during the COVID-19 pandemic in Brazil: a time-series analysis of one million prescriptions.
Topics: Adult; Analgesics, Opioid; Brazil; COVID-19; Fentanyl; Humans; Methadone; Morphine; Opioid-Related Disorders; Pandemics; Prescriptions; Remifentanil; Sufentanil; Tramadol | 2023 |
Distribution of morphine and methadone to the brain in a developmental chicken embryo model.
Topics: Analgesics, Opioid; Animals; Brain; Chick Embryo; Chickens; Chromatography, Liquid; Drug Tolerance; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Pregnancy; Receptors, Opioid, mu; Tandem Mass Spectrometry | 2023 |
A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.
Topics: Adult; Cocaine; Dronabinol; Female; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Immunoassay; Infant, Newborn; Meconium; Methadone; Narcotics; New York City; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Prevalence; Reproducibility of Results; Substance Abuse Detection; Substance-Related Disorders | 1994 |
Neonatal hair analysis contribution to establishing a gestational drug exposure profile and predicting a withdrawal syndrome.
Topics: Cannabinoids; Cocaine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Infant, Newborn; Meconium; Methadone; Narcotics; Neonatal Abstinence Syndrome; Pregnancy; Substance Abuse Detection | 2003 |
Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, 2-ethyl-5-methyl-3,3-diphenylpyraline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry.
Topics: Atmospheric Pressure; Humans; Mass Spectrometry; Meconium; Methadone; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Comparison of drugs of abuse detection in meconium by EMIT II and ELISA.
Topics: Amphetamines; Analgesics, Opioid; Barbiturates; Benzodiazepines; Cannabinoids; Chromatography, Liquid; Cocaine; Dextropropoxyphene; Enzyme Multiplied Immunoassay Technique; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Female; Fetus; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Infant, Newborn; Maternal-Fetal Exchange; Meconium; Methadone; Phencyclidine Abuse; Pregnancy; Sensitivity and Specificity; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry | 2009 |
Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disorders; Female; Gestational Age; Humans; Infant, Newborn; Length of Stay; Meconium; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opiate Substitution Treatment; Opioid-Related Disorders; Predictive Value of Tests; Pregnancy; Pregnancy Complications; Premature Birth; Prenatal Exposure Delayed Effects; Prospective Studies; Substance Abuse Detection; Young Adult | 2010 |
Alternative matrices for cocaine, heroin, and methadone in utero drug exposure detection.
Topics: Chromatography, Liquid; Cocaine; Drug Monitoring; Female; Hair; Heroin; Humans; Maternal-Fetal Exchange; Meconium; Methadone; Placenta; Pregnancy; Substance Abuse Detection; Tandem Mass Spectrometry; Umbilical Cord; Uterus | 2013 |
Rates of fetal polydrug exposures in methadone-maintained pregnancies from a high-risk population.
Topics: Adult; Cocaine; Female; Humans; Infant, Newborn; Meconium; Methadone; Opiate Substitution Treatment; Pregnancy | 2013 |
Bioanalysis for cocaine, opiates, methadone, and amphetamines exposure detection during pregnancy.
Topics: Amphetamines; Analgesics, Opioid; Anesthetics, Local; Central Nervous System Stimulants; Cocaine; Female; Hair; Humans; Infant, Newborn; Meconium; Methadone; Opiate Alkaloids; Pregnancy; Substance Abuse Detection; Tandem Mass Spectrometry; Umbilical Cord | 2017 |
Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords.
Topics: Analgesics, Opioid; Central Nervous System Stimulants; Chromatography, Liquid; Cocaine; Female; Humans; Meconium; Metabolomics; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Prospective Studies; Substance Abuse Detection; Tandem Mass Spectrometry; Umbilical Cord | 2020 |