methadone has been researched along with methadyl acetate in 286 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 220 (76.92) | 18.7374 |
| 1990's | 14 (4.90) | 18.2507 |
| 2000's | 47 (16.43) | 29.6817 |
| 2010's | 5 (1.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bloch, R; Deneau, GA; Misra, AL; Mulé, SJ; Vardy, J | 1 |
| Goldstein, MG; Sollod, RM | 1 |
| Serban, G | 1 |
| Braude, MC; Lambert, CS; Maickel, RP; Zabik, JE | 1 |
| Horng, JS; Smits, SE; Wong, DT | 1 |
| Baskerville, JC; Brands, B; Gowdey, CW; Hirst, M | 2 |
| Harris, LS; Martin, BR; Toro-Goyco, E | 1 |
| Bates, TR; Bloch, R; Misra, AL; Mulé, SJ | 1 |
| Casella, GA; Deneau, GA; Mule, SJ | 1 |
| Boldt, KG; Brine, GA; Carroll, FI; Moreland, CG | 1 |
| Misra, AL; Mulé, SJ | 3 |
| Greenstein, R; O'Brien, CP; Woody, GE | 1 |
| Ling, W | 1 |
| Blaine, JD | 1 |
| Charuvastra, VC | 1 |
| Klett, CJ | 1 |
| Levine, GL; Whysner, JA | 1 |
| Renault, PF | 1 |
| Downs, DA | 1 |
| Crowley, TJ; Egan, DJ; Hydinger-Macdonald, MJ; Jones, RH; Lingle, JR; Wagner, JE | 1 |
| Bedford, JA; Guinn, MM; Masten, LW; Wilson, MC | 1 |
| Barnes, TB; Masten, LW | 1 |
| Kraus, JL; Yaouanc, JJ | 1 |
| Howd, RA; Pryor, GT | 1 |
| Newmann, MC; Thomas, DB; Whysner, JA | 1 |
| Etherton, DS; Riley, AL; Shapiro, RM | 1 |
| Eikenburg, DC; Keedy, JD; Stickney, JL | 2 |
| Charuvastra, C; Ling, W; Thomas, DB; Whysner, JA | 1 |
| Bloch, R; Misra, AL; Mulé, SJ | 1 |
| Henderson, GL; Kuttab, SH; North-Root, H | 1 |
| Cooper, J | 1 |
| Khazan, N; Meltzer, LT; Moreton, JE; Young, GA | 1 |
| Khazan, N; Steinfels, GF; Young, GA | 6 |
| Inturrisi, CE; Kaiko, RF | 1 |
| Braude, MC; Downs, DA | 1 |
| Blaine, JD; Levine, GL; Renault, P; Whysner, JA | 1 |
| Dorus, W; Renault, PF; Senay, EC | 1 |
| Charuvastra, VC; Ouren, J; Panell, J | 1 |
| Braude, MC; Downs, DA; Thomas, DJ | 1 |
| Chiba, S; Khazan, N; Moreton, JE; Young, GA | 1 |
| Downs, DA; Harrigan, SE | 1 |
| Mcgivney, WT; McMillan, DE | 2 |
| Holtzman, SG | 1 |
| Eikenburg, DC; Stickney, JL | 2 |
| Chinn, DM; Crouch, DJ; Finkle, BS; Jennison, TA | 1 |
| Franklin, MR; Roberts, SM | 1 |
| Downs, DA; Wiley, JN | 1 |
| Keedy, JD; Stickney, JL | 2 |
| Desmond, DP | 1 |
| Goldstein, A; Judson, BA | 2 |
| Chiba, S; Khazan, N; Moreton, EJ | 1 |
| Masten, LW | 1 |
| Resnick, RB | 1 |
| Goldstein, A; Judson, BA; Trueblood, B | 1 |
| Catravas, JD; Davis, WM; Guinn, MM; Waters, IW | 1 |
| Stickney, JL | 4 |
| Henderson, GL; Lau, DH | 2 |
| Burnett, CJ; Masten, LW; Price, SR | 1 |
| Agner, TG; Balster, RL | 1 |
| Charuvastra, VC; Fu, TK; Jarvik, LF; Matsuyama, SS; Sanders, K; Yen, FS | 1 |
| Aigner, TG; Balster, RL; Ford, RD | 1 |
| Jindal, SP; Lutz, T; Vestergaard, P | 1 |
| Chen, RC; Ho, AK; Ho, CC | 1 |
| Gillis, RD; Klett, CJ; Ling, W | 2 |
| Field, FH; Smit, AL | 1 |
| Wood, W; Youatt, R | 1 |
| Charuvastra, VC; Klett, CJ; Ling, W | 1 |
| Charuvastra, C; Kaim, SC; Klett, CJ; Ling, W | 1 |
| Blaine, J; Renault, P | 1 |
| Whysner, JA | 1 |
| Archer, S; Wolven, A | 1 |
| Goldstein, A; Judson, B | 1 |
| Blachly, PH; Carlson, E; Irwin, S; Loewen, J; Marks, J; Reade, N | 1 |
| Blachly, P; Carter, CC; Irwin, S; Marks, J | 1 |
| Bottomly, DR; Cooler, PM; Irwin, S; Kinohi, RG | 1 |
| Blachly, PH; Jaffe, JH; Schuster, CR; Smith, BB | 1 |
| Jaffe, JH; Senay, EC | 1 |
| Dimenza, S; Jaffe, JH; Renault, PF; Schuster, CR; Senay, EC; Smith, B | 1 |
| Lehmann, WX | 1 |
| Curran, S; Karp, E; Savage, C | 1 |
| Dimenza, S; Jaffe, JH; Renault, PF; Senay, EC | 1 |
| Collier, WE; Daniels, SJ; Dimenza, S; Dorus, W; Renault, PF; Senay, EC | 1 |
| Charuvastra, VC; Kaim, SC; Klett, CJ; Ling, W | 1 |
| Archer, S | 2 |
| Inturrisi, CE | 1 |
| Brocco, MJ; Killam, KF; Robinson, CA | 1 |
| Henderson, GL; Lau, DH; Wilson, BK | 1 |
| Bhushan, RS; Davidson, PP; Kochhar, MM | 1 |
| Tse, FL; Welling, PG | 1 |
| Goldstein, A; Grevert, P; Masover, B | 1 |
| Crofford, MJ; Hui, FW; Smith, AA | 1 |
| Berkowitz, BA; Lee, CH | 1 |
| Henderson, GL; Skrumsager, BK | 1 |
| Hasegawa, AT; Roerig, DL; Wang, RI | 2 |
| Bellward, GD; Li, M; Lopaschuk, GD; Warren, P | 1 |
| Swanson, DA | 1 |
| Freedman, AM; Geyer, G; Kestenbaum, RS; Orlin, L; Resnick, RB; Schuyten-Resnick, E | 1 |
| Karp-Gelernter, E; Savage, C; Wurmser, L | 1 |
| Brine, GA; Carroll, FI; Chen, T; Kohl, DW; Welch, CD | 1 |
| Goldstein, A | 3 |
| Blachly, PH | 1 |
| Blachly, PH; David, NA; Irwin, S | 1 |
| Fraser, HF; Isbell, H | 2 |
| Henderson, GL | 1 |
| Chatterjie, N; Inturrisi, CE; Kaiki, RF | 1 |
| Inturrisi, C; Kaiki, RF | 1 |
| Fink, M; Freedman, AM; Levine, R; Zaks, A | 1 |
| Fink, M; Freedman, AM; Zaks, A | 1 |
| Spannagel, V; Thomson, CP; Wilson, BK | 1 |
| Everson, A; Segal, R; Sellers, EM; Thakur, R | 1 |
| Chen, RC; Ho, AK | 1 |
| Billings, RE; Blake, DA; McMahon, RE | 1 |
| Chatterjie, N; Inturrisi, CE; Kaiko, RF | 1 |
| Chatterjie, N; Inturrisi, CE | 1 |
| Henderson, GL; Rosenkranz, RP | 1 |
| McCarthy, DA; McLean, JR; Nuite, JA; Tessman, DK; Wax, J | 1 |
| Klett, CJ; Newmann, MC; Stillman, R | 1 |
| Hough, G; Murphy, BF; Plumb, M; Taintor, Z | 1 |
| Kauders, F; Schecter, A | 2 |
| Crawford, J; Parwatikar, S; Unverdi, C | 1 |
| Henderson, GL; Westkaemper, R | 1 |
| Inturrisi, CE; Mendelson, JH; Renault, P; Senay, EC | 1 |
| Fraser, AD | 1 |
| Schuster, CR; Snyder, M | 1 |
| Walton, RG | 1 |
| Gibson, A; Vernadakis, A | 1 |
| Dorozynsky, L; McGahan, P; McLellan, AT; Zangwell, BC | 1 |
| Fleischman, RW; Rosenkrantz, H | 1 |
| Pumphrey, E; Rawson, RA; Seecof, R; Tennant, FS | 1 |
| Crowley, TJ; Macdonald, MJ; Zerbe, G | 1 |
| Crowley, TJ; Macdonald, MJ; Wagner, JE; Zerbe, G | 1 |
| Kuttab, SH; Nowshad, F; Shargel, L | 1 |
| DePace, A; Mulé, SJ; Verebey, K | 1 |
| Amsterdam, EA; Henderson, GL; Mason, DT; Rendig, SV | 1 |
| Harris, GJ; Hasegawa, AT; Lynch, KL; Roerig, DL; Wang, RI | 1 |
| Tennant, FS | 1 |
| Jeziorski, K; Matsumoto, H | 1 |
| Toro-Goyco, E | 1 |
| Kuwahara, MD; Sparber, SB | 3 |
| Gardner, EL; Makman, MH; Walczak, SA | 1 |
| Caviness, B; Greene, DL; Hudson, RG; Lattin, DL; Raible, PK; Richardson, JB | 1 |
| Goldstein, A; Inturrisi, CE; Judson, BA | 1 |
| Geyer, G; Resnick, RB; Washton, AM | 1 |
| Dorus, W; Hargreaves, WA; Ling, W; Resnick, R; Senay, E; Tuason, VB | 1 |
| Hough, G; Resnick, RB; Washton, AM | 1 |
| Senay, EC | 1 |
| Dewey, WL | 1 |
| Braude, M; Brockman, H; Brusick, D; Hung, C; Jagannath, D; Matheson, D | 1 |
| Langley, AE; Smith, SG; Zeid, RL | 1 |
| Lichtblau, L; Messing, RB; Sparber, SB | 1 |
| Gibson, DA; Vernadakis, A | 1 |
| Moerschbaecher, JM; Thompson, DM; Winsauer, PJ | 1 |
| Benowitz, N; Hargreaves, WA; Sorensen, JL; Tyler, J; Weinberg, JA | 1 |
| Lichtblau, L; Mercurio, SD; Sparber, SB | 1 |
| Ellingboe, J; Goldstein, A; Judson, BA; Mendelson, JH | 1 |
| Fraenkel, HM; van Ree, JM | 1 |
| Freeman, RW; Harbison, RD; James, RC | 1 |
| Brocco, M; McMillan, DE | 1 |
| Karp-Gelernter, E; McCabe, OL; Savage, C | 1 |
| Bartolomeo, JG; Bates, TR; Bloch, R; Misra, AL; Mulé, SJ | 1 |
| Khazan, N; Lukas, SE; Moreton, JE | 3 |
| Jones, SE; McGillkiard, KL; Olsen, GD; Robertson, GE | 1 |
| Hargreaves, WA; Sorensen, JL; Weinberg, JA | 3 |
| Garwood, J; Perzel, J; Resnick, RB; Washton, AM | 1 |
| Lichtblau, L; Sparber, SB | 3 |
| Harris, LS; Man, M; Martin, BR; Woods, LA | 1 |
| Blaine, JD; Renault, PR; Thomas, DB; Whysner, JA | 1 |
| Finkle, BS; Lichtblau, L; Sparber, SB | 1 |
| Harbison, RD; James, RC | 1 |
| Kirlangitis, J; Langley, AE; Lehman, TM; Zeid, R | 1 |
| Burklund, KE; Lichtblau, L; Sparber, SB | 1 |
| Khazan, N; Steinfels, GF; Wolf, DL; Young, GA | 1 |
| Kirlangitis, J; Langley, AE; Lehman, T | 1 |
| Bellward, GD; Gontovnick, LS | 1 |
| Campos-Flor, S; Inturrisi, CE; Kiang, CH | 1 |
| Czertko, G; Freedman, RR | 1 |
| Blakis, M; Carter, WE; Holmes, ED; Klett, CJ; Ling, W | 1 |
| Falek, A; Hollingsworth, F | 1 |
| Gillis, RD; Klett, JC; Ling, W | 1 |
| McGilliard, KL; Olsen, GD | 1 |
| Kacian, J; Marcovici, M; McLellan, AT; O'Brien, CP | 1 |
| Charuvastra, VC; Ling, W; Ouren, J; Panell, J | 1 |
| Charuvastra, VC; Jarvik, L; Matsuyama, SS; Ouren, J; Schwartz, J | 1 |
| Wodak, A | 1 |
| Yang, G | 1 |
| Miguel, N; Patricio, LD | 1 |
| Kreek, MJ | 2 |
| Brandt, MR; Cabansag, SR; France, CP | 1 |
| Jasinski, DR; Vaupel, DB | 1 |
| Alburges, ME; Collins, JM; Moody, DE; Parker, RJ; Strong, JM | 1 |
| Chalmers, T; Glanz, M; Klawansky, S; McAullife, W | 1 |
| Gygi, SP; Nagasawa, PR; Rollins, DE; Valdez, AS; Wilkins, DG | 1 |
| Wartenberg, AA | 1 |
| Bigelow, GE; Buchhalter, AR; Eissenberg, T; Stitzer, ML; Walsh, SL | 1 |
| Armendariz, GA; Cheever, ML; Moody, DE | 1 |
| Fiellin, DA; O'Connor, PG | 1 |
| Bigelow, GE; Chutuape, MA; Johnson, RE; Stitzer, ML; Strain, EC; Walsh, SL | 1 |
| O'Connor, PG | 1 |
| Kharasch, ED; Oda, Y | 1 |
| Stimmel, B | 1 |
| Camí, J; Farré, M; Mas, A; Moreno, V; Torrens, M | 1 |
| Cone, EJ; Preston, KL | 1 |
| Ali, RL; Danz, C; Kneebone, J; La Vincente, SF; Newcombe, DA; White, JM | 1 |
| Ali, RL; Gowing, LR; White, JM | 1 |
| Clark, N; Dunlop, A; Gijsbers, A; Ling, W; Lintzeris, N; Ritter, A; Whelan, G | 1 |
| Appel, P; Borg, L; Ho, A; Joseph, H; Kreek, MJ; Moody, D; Wells, A | 1 |
| Kreek, MJ; Vocci, FJ | 1 |
| Beardsley, PM; May, EL; Newman, JL; Vann, RE | 1 |
| Ebert, SN; Katchman, AN; Kilborn, MJ; Kornick, CA; Manfredi, PL; McGroary, KA; Woosley, RL | 1 |
| Compton, M; Ling, W; Rawson, RA | 1 |
| Kleber, HD | 1 |
| Colker, AC | 1 |
| EDDY, NB; LEIMBACH, DG | 1 |
| Ishøy, T; Iversen, C | 1 |
| Bammer, G; Clark, N; Kutin, JJ; Lintzeris, N; Panjari, M; Ritter, AJ | 1 |
| Dietze, P; Lenné, MG; Redman, JR; Rumbold, GR; Triggs, TJ | 1 |
| Horst, DA; Humphreys, K; Minkel, JD; Oliva, EM; Trafton, JA | 1 |
| Krantz, MJ; Mehler, PS | 1 |
| BEECHER, HK; KEATS, AS | 1 |
| Digiusto, E; Mattick, RP; O'Brien, S; Ritter, A; Shakeshaft, A | 1 |
| Caplehorn, J | 1 |
| Cunningham-Rathner, J; Ling, W; Rawson, R | 1 |
| Bochner, F; Newcombe, DA; Somogyi, AA; White, JM | 1 |
| Anglin, MD; Annon, J; Longshore, D; Rawson, RA | 1 |
| Beilenson, P; Bishai, D; Cornelius, L; Havens, JR; Huettner, S; Latkin, CA; Lloyd, JJ; Rapp, C; Ricketts, EP; Strathdee, SA | 1 |
| Bigelow, GE; Johnson, RE; Marsch, LA; Mudric, T; Stephens, MA; Strain, EC | 1 |
| Humphreys, K; McKellar, JD; Trafton, JA; Villafranca, SW | 1 |
| Foster, DJ; Morrish, GA; Somogyi, AA | 1 |
| Clark, NC; Dietze, P; Lenné, MG; Redman, JR | 1 |
| Angrist, B; Baker, SA; Elkashef, A; Leiderman, D; Majewska, D; Montgomery, A; O'leary, S; Reid, MS; Robinson, J; Rotrosen, J; Schwartz, M; Stone, J | 1 |
| Fairbairn, N; Kerr, T; Maas, B; Montaner, J; Wood, E | 1 |
| Bigelow, GE; Brooner, RK; Johnson, RE; Lott, DC; Strain, EC | 1 |
| Humphreys, K; Oliva, EM; Tracy, SW; Trafton, JA | 1 |
| Arnsten, JH; Gourevitch, MN; Kunins, HV; Whitley, SD | 1 |
| Brawand, M; Crettol, S; Digon, P; Eap, CB; Golay, KP | 1 |
| Anglin, MD; Annon, J; Conner, BT; Longshore, D | 2 |
| Bigelow, GE; Haigney, MC; Johnson, RE; Nuzzo, PA; Wedam, EF | 1 |
| Chopra, MP; Feldman, Z; Mancino, MJ; Oliveto, A | 1 |
| Anglin, MD; Annon, JJ; Conner, BT; Longshore, D | 1 |
| Finkbeiner, T; Gastpar, M; Heinrich, C; Heitkamp, R; Poehlke, T; Scherbaum, N; Wolstein, J | 1 |
| Breuckmann, F; Conrads, H; Erbel, R; Gastpar, M; Scherbaum, N; Wieneke, H; Wolstein, J | 1 |
| Amato, L; Davoli, M; Minozzi, S | 1 |
| Cohen, J | 1 |
| Choo, RE; Dams, R; Gray, TR; Huestis, MA; Jones, HE | 1 |
| Gordon, MS; Gryczynski, J; Kelly, SM; Kinlock, TW; O'Grady, KE; Schwartz, RP | 1 |
| Amato, L; Bellisario, C; Davoli, M; Minozzi, S | 1 |
| Bochner, F; Newcombe, DAL; Somogyi, AA; White, JM | 1 |
24 review(s) available for methadone and methadyl acetate
| Article | Year |
|---|---|
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors | 1976 |
Introduction. Roc: 3x/week LAAM: alternative to methadone.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinical; Female; Government; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Research Design; Research Support as Topic; Substance Withdrawal Syndrome; United States | 1976 |
Toxicology of LAAM.
Topics: Animals; Behavior, Animal; Body Weight; Dogs; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Drug Tolerance; Eating; Female; Fetal Death; Lactation; Lethal Dose 50; Liver; Male; Methadone; Methadyl Acetate; Organ Size; Pregnancy; Rabbits; Rats; Reproduction; Teratogens | 1976 |
Pharmacology of LAAM.
Topics: Analgesics; Animals; Behavior, Animal; Dogs; Drug Evaluation, Preclinical; Female; Haplorhini; Humans; Kinetics; Male; Methadone; Methadyl Acetate; Mice; Morphine; Nalorphine; Rabbits; Rats; Stereoisomerism; Substance-Related Disorders; Time Factors | 1976 |
Disposition of narcotics and narcotic antagonists.
Topics: Animals; Biotransformation; Chickens; Dogs; Guinea Pigs; Haplorhini; Humans; Male; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Narcotics; Pupil; Rabbits; Rats; Time Factors | 1976 |
Clinical toxicology of drugs used in the treatment of opiate dependency.
Topics: Buprenorphine; Clonidine; Humans; Methadone; Methadyl Acetate; Naltrexone; Opioid-Related Disorders | 1990 |
[Treatment of opiate withdrawal syndromes (historical review)].
Topics: Antipsychotic Agents; Clonidine; Drug Evaluation; History, 19th Century; History, 20th Century; Humans; Methadone; Methadyl Acetate; Morphine; Narcotic Antagonists; Phenothiazines; Substance Withdrawal Syndrome | 1984 |
Clinical status of methadyl acetate (LAAM).
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Humans; Kinetics; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders | 1981 |
Managing illicit drug use. A practical guide.
Topics: Buprenorphine; Counseling; Disulfiram; Humans; Methadone; Methadyl Acetate; Naltrexone; Psychotherapy; Self-Help Groups; Substance Abuse Treatment Centers; Substance-Related Disorders | 1994 |
Biological correlates of methadone maintenance pharmacotherapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Chromatography, Gas; Cocaine; Heroin Dependence; Humans; Illicit Drugs; Infant, Newborn; Methadone; Methadyl Acetate; Morphine Dependence; Narcotics; Opioid-Related Disorders; Substance Abuse, Intravenous; Time Factors | 1994 |
Methadone vs. L-alpha-acetylmethadol (LAAM) in the treatment of opiate addiction. A meta-analysis of the randomized, controlled trials.
Topics: Adult; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome | 1997 |
Treatment considerations in the opioid dependent patient.
Topics: Analgesics, Opioid; Buprenorphine; Drug and Narcotic Control; Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders; Treatment Outcome | 1999 |
Pharmacologic treatment of heroin-dependent patients.
Topics: Analgesics, Opioid; Buprenorphine; Counseling; Heroin Dependence; Humans; Mental Disorders; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Physician's Role; Substance Withdrawal Syndrome | 2000 |
Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine.
Topics: Adrenocorticotropic Hormone; beta-Endorphin; Corticotropin-Releasing Hormone; Heroin Dependence; Humans; Hypothalamo-Hypophyseal System; Methadone; Methadyl Acetate; Pituitary-Adrenal System; Pro-Opiomelanocortin | 2000 |
Retention rate and illicit opioid use during methadone maintenance interventions: a meta-analysis.
Topics: Buprenorphine; Humans; Methadone; Methadyl Acetate; Narcotics; Opioid-Related Disorders; Patient Dropouts; Randomized Controlled Trials as Topic; Substance Abuse Detection; Treatment Outcome | 2002 |
Toxicologic aspects of heroin substitution treatment.
Topics: Buprenorphine; Hair; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Narcotics; Saliva; Sweat | 2002 |
LAAM maintenance vs methadone maintenance for heroin dependence.
Topics: Clinical Trials as Topic; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Narcotics | 2002 |
History and current status of opioid maintenance treatments: blending conference session.
Topics: Buprenorphine; Clinical Trials as Topic; History, 20th Century; Humans; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders | 2002 |
Pharmacologic treatments for heroin and cocaine dependence.
Topics: Buprenorphine; Clonidine; Cocaine-Related Disorders; Comorbidity; Heroin Dependence; Humans; Mental Disorders; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Narcotics | 2003 |
Behavioral health issue brief: pharmacotherapy treatment of alcoholism and drug addiction: overview and bibliography: year end report-2002.
Topics: Alcohol Deterrents; Alcoholism; Analgesics, Opioid; Buprenorphine; Drug Therapy; Humans; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Substance-Related Disorders; United States | 2002 |
Treating opioid dependence. Growing implications for primary care.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Europe; Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders; Prevalence; Primary Health Care; Substance Withdrawal Syndrome; United States | 2004 |
Pharmacokinetic interactions between HIV antiretroviral therapy and drugs used to treat opioid dependence.
Topics: Animals; Anti-HIV Agents; Buprenorphine; Drug Interactions; Humans; Methadone; Methadyl Acetate; Narcotic Antagonists; Narcotics; Opioid-Related Disorders | 2006 |
Maintenance treatments for opiate dependent adolescent.
Topics: Adolescent; Buprenorphine; Humans; Methadone; Methadyl Acetate; Naloxone; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Young Adult | 2009 |
Maintenance treatments for opiate -dependent adolescents.
Topics: Adolescent; Buprenorphine; Humans; Maintenance Chemotherapy; Methadone; Methadyl Acetate; Naloxone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic | 2014 |
56 trial(s) available for methadone and methadyl acetate
| Article | Year |
|---|---|
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Heroin; Heroin Dependence; Humans; Kinetics; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Patient Dropouts; Substance Withdrawal Syndrome; Time Factors | 1976 |
Multimodality treatment of narcotic addiction: an overview.
Topics: Ambulatory Care; Behavior Therapy; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Humans; Methadone; Methadyl Acetate; Narcotic Antagonists; Narcotics; Psychoses, Substance-Induced; Psychotherapy; Substance-Related Disorders; Therapeutic Community | 1978 |
Early clinical studies of levo-alpha acetylmethadol (LAAM): an opiate for use in the medical treatment of chronic heroin dependence.
Topics: Arousal; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Emotions; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Pain, Intractable; Substance Withdrawal Syndrome | 1978 |
A U.S. Veterans Administration cooperative study on methadyl acetate.
Topics: Adolescent; Adult; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Patient Compliance; United States; United States Department of Veterans Affairs | 1978 |
Every-other-day acetylmethadol disturbs circadian cycles of human motility.
Topics: Adult; Circadian Rhythm; Drug Administration Schedule; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Motor Activity; Time Factors | 1979 |
The phase III clinical evaluation of LAAM: I. Comparative epidemiology of mortality in LAAM and methadone.
Topics: Clinical Trials as Topic; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Mortality | 1979 |
On the relative efficacy of LAAM and methadone.
Topics: Clinical Trials as Topic; Double-Blind Method; Heroin Dependence; Humans; Methadone; Methadyl Acetate | 1979 |
Methadyl acetate and methadone. An open comparison.
Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Morphine; Substance Withdrawal Syndrome | 1977 |
Methadyl acetate versus methadone: the experience of one hospital.
Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Morphine; Patient Dropouts | 1977 |
Acceptability of methadyl acetate (LAAM) as compared with methadone in a treatment program for heroin addicts.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Middle Aged; Surveys and Questionnaires | 1978 |
Chromosomes in patients receiving methadone and methadyl acetate.
Topics: Adult; Chromosome Aberrations; Double-Blind Method; Heroin Dependence; Humans; Leukocytes; Male; Methadone; Methadyl Acetate; Middle Aged; Time Factors | 1978 |
A cooperative clinical study of methadyl acetate. I. Three-times-a-week regimen.
Topics: Adult; Blood Pressure; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Compliance; Patient Dropouts; Research Design; Time Factors | 1978 |
Current status of the evaluation of LAAM as a maintenance drug for heroin addicts.
Topics: Adolescent; Adult; Blood Cells; Body Weight; Bone Marrow; Clinical Trials as Topic; Drug Evaluation; Heroin Dependence; Hospitals, Veterans; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Patient Dropouts; Pulse; Research Design; Time Factors | 1975 |
Methadyl acetate and methadone as maintenance treatments for heroin addicts. A veterans administration cooperative study.
Topics: Adolescent; Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Patient Acceptance of Health Care | 1976 |
Introduction. Roc: 3x/week LAAM: alternative to methadone.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinical; Female; Government; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Research Design; Research Support as Topic; Substance Withdrawal Syndrome; United States | 1976 |
Summary of SAODAP Phase II cooperative study of LAAM vs. methadone.
Topics: Adult; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts | 1976 |
Phase III clinical study of levo-alpha-acetylmethadol.
Topics: Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Emotions; Female; Follow-Up Studies; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Pregnancy; Research Design; Self Administration; Substance Withdrawal Syndrome | 1976 |
Can the community be protected against the hazards of take-home methadone? 1974 [proceedings].
Topics: Administration, Oral; Clinical Trials as Topic; Humans; Male; Methadone; Methadyl Acetate; Social Problems; Substance-Related Disorders | 1976 |
The behavioral, cognitive and physiologic effects of long-term methadone and methadyl treatment. 1973 [proceedings].
Topics: Behavior; Clinical Trials as Topic; Cognition; Drug Administration Schedule; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts | 1976 |
Preliminary observations with acute and chronic methadone and 1-alpha-acetylmethadol administration in humans.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Tolerance; Female; Humans; Male; Methadone; Methadyl Acetate; Morphine; Substance-Related Disorders; Time Factors | 1976 |
Acute time-dose-response effects of cyclazocine, methadone, and methadyl in man. 1975 [proceedings].
Topics: Adult; Clinical Trials as Topic; Cyclazocine; Dose-Response Relationship, Drug; Humans; Male; Methadone; Methadyl Acetate; Time Factors | 1976 |
Comparison of acetylmethadol and methadone in the treatment of long-term heroin users: a pilot study. 1973 [proceedings].
Topics: Clinical Trials as Topic; Drug Evaluation; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Pilot Projects | 1976 |
Methadone and 1-methadyl acetate: use in management of narcotic addicts. 1971 [proceedings].
Topics: Clinical Trials as Topic; Drug Evaluation; Humans; Male; Methadone; Methadyl Acetate; Narcotics; Substance-Related Disorders | 1976 |
Methadyl acetate vs methadione: a double-blind study in heroin users. 1972 [proceedings].
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged | 1976 |
The use of 1-alpha-acetyl-methadol (LAAM) as compared to methadone in the maintenance and detoxification of young heroin addicts. 1973 [proceedings].
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate | 1976 |
A methadone/1-alpha-acetylmethadol (LAAM) maintenance study [proceedings].
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts | 1976 |
A 48-week study of methadone, methadyl acetate, and minimal services. 1974 [proceedings].
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Health Services; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged | 1976 |
Three times a week LAAM equals seven times a week methadone: a preliminary report of a control study. 1974 [proceedings].
Topics: Adult; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate | 1976 |
Summary of Veterans Administration Phase II cooperative study for LAAM and methadone.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Heroin Dependence; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Middle Aged; Morphine; Patient Dropouts; Self Administration; United States; United States Department of Veterans Affairs | 1976 |
How effective is LAAM treatment? Clinical comparison with methadone.
Topics: Alcohol Drinking; Alcoholic Intoxication; Clinical Trials as Topic; Follow-Up Studies; Humans; Male; Methadone; Methadyl Acetate; Substance-Related Disorders | 1986 |
Methadyl acetate (LAAM) in the treatment of heroin addicts. II. Double-blind comparison of gradual and abrupt detoxification.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Naltrexone; Outcome and Process Assessment, Health Care; Placebos; Substance Withdrawal Syndrome | 1983 |
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects.
Topics: Adult; Ambulatory Care; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1983 |
Alternative induction and crossover schedules for methadyl acetate.
Topics: Adolescent; Adult; Attitude to Health; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts; Placebos; Random Allocation; Substance Withdrawal Syndrome | 1984 |
Evaluation of clinic attendance schedules for LAAM and methadone: a controlled study.
Topics: Adult; Clinical Trials as Topic; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Patient Compliance; Patient Dropouts; Random Allocation | 1982 |
Clinical status of methadyl acetate (LAAM).
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Humans; Kinetics; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders | 1981 |
Withdrawal from heroin in three or six weeks. Comparison of methadyl acetate and methadone.
Topics: Adult; Ambulatory Care; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Substance Withdrawal Syndrome | 1982 |
A comparison of thrice weekly LAAM and daily methadone in employed heroin addicts.
Topics: Adult; Attitude; Employment; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Methadyl Acetate; Patient Compliance; Random Allocation | 1981 |
Restabilization with methadone after methadyl acetate maintenance.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged | 1980 |
A cooperative clinical study of methadyl acetate. II. Friday-only regimen.
Topics: Adult; Drug Administration Schedule; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Outcome and Process Assessment, Health Care; Substance Withdrawal Syndrome | 1980 |
Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions.
Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Pupil; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Surveys and Questionnaires; Time Factors | 1999 |
A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine-Related Disorders; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Opioid-Related Disorders; Treatment Outcome | 2000 |
Relationship between LAAM-methadone preference and treatment outcomes.
Topics: Adult; Chi-Square Distribution; Cross-Over Studies; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Patient Satisfaction; Statistics, Nonparametric; Treatment Outcome | 2002 |
A randomized trial comparing levo-alpha acetylmethadol with methadone maintenance for patients in primary care settings in Australia.
Topics: Adult; Australia; Family Practice; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Outcome Assessment, Health Care; Treatment Outcome | 2003 |
The effects of the opioid pharmacotherapies methadone, LAAM and buprenorphine, alone and in combination with alcohol, on simulated driving.
Topics: Adult; Automobile Driving; Buprenorphine; Drug Combinations; Ethanol; Female; Humans; Male; Methadone; Methadyl Acetate; Narcotics; Opioid-Related Disorders; Victoria | 2003 |
Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2004 |
Levo-alpha-acetylmethadol (LAAM) versus methadone: treatment retention and opiate use.
Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Multivariate Analysis; Narcotic Antagonists; Narcotics; Patient Compliance | 2005 |
Facilitating entry into drug treatment among injection drug users referred from a needle exchange program: Results from a community-based behavioral intervention trial.
Topics: Adult; Baltimore; Behavior Therapy; Case Management; Community Mental Health Services; Female; Health Services Accessibility; HIV Seroprevalence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Motivation; Narcotics; Needle-Exchange Programs; Opioid-Related Disorders; Patient Acceptance of Health Care; Referral and Consultation; Substance Abuse, Intravenous; Transportation; Urban Population | 2006 |
Predictors of outcome in LAAM, buprenorphine, and methadone treatment for opioid dependence.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Double-Blind Method; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders; Prospective Studies; Receptors, Opioid, mu; Regression Analysis; Treatment Outcome | 2005 |
A placebo controlled, double-blind study of mecamylamine treatment for cocaine dependence in patients enrolled in an opiate replacement program.
Topics: Administration, Cutaneous; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Drug Evaluation, Preclinical; Female; Humans; Male; Mecamylamine; Methadone; Methadyl Acetate; Narcotics; New York City; Nicotinic Antagonists; Treatment Outcome; Urban Population | 2005 |
HIV risk behaviors during pharmacologic treatment for opioid dependence: a comparison of levomethadyl acetate [corrected] buprenorphine, and methadone.
Topics: Adult; Buprenorphine; Double-Blind Method; Drug Administration Schedule; Female; HIV Infections; Humans; Male; Methadone; Methadyl Acetate; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Risk-Taking | 2006 |
Levo-alpha-acetylmethadol (LAAM) versus methadone maintenance: 1-year treatment retention, outcomes and status.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heroin Dependence; Humans; Los Angeles; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Patient Compliance; Treatment Outcome | 2007 |
Effect of religiosity and spirituality on drug treatment outcomes.
Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Religion and Medicine; Spirituality; Treatment Outcome | 2009 |
Longitudinal effects of LAAM and methadone maintenance on heroin addict behavior.
Topics: Adult; Aged; Crime; Heroin Dependence; HIV Infections; Humans; Longitudinal Studies; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Risk-Taking; Treatment Outcome; Young Adult | 2009 |
A randomized, open-label trial comparing methadone and Levo-Alpha-Acetylmethadol (LAAM) in maintenance treatment of opioid addiction.
Topics: Adult; Analgesics, Opioid; Europe; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders; Pain Measurement; Severity of Illness Index; Sex Factors; Spirometry; Survival Analysis; Young Adult | 2009 |
Levo-alpha-acetylmethadol (LAAM) induced QTc-prolongation - results from a controlled clinical trial.
Topics: Adult; Electrocardiography; Female; Heart Rate; Heroin Dependence; Humans; Long QT Syndrome; Male; Methadone; Methadyl Acetate; Narcotics | 2009 |
Impaired psychomotor function and plasma methadone and levo-alpha-acetylmethadol (LAAM) concentrations in opioid-substitution patients.
Topics: Adult; Drug Tolerance; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opiate Substitution Treatment; Opioid-Related Disorders; Psychomotor Performance; Time Factors; Young Adult | 2017 |
209 other study(ies) available for methadone and methadyl acetate
| Article | Year |
|---|---|
Pharmacokinetics and metabolism of (-)-alpha-[2-3H]acetylmethadol (LAAM) in the monkey: evidence for a new metabolite.
Topics: Animals; Feces; Female; Haplorhini; Kinetics; Macaca mulatta; Methadone; Methadyl Acetate; Time Factors | 1976 |
New approach to the rehabilitation of the hard core drug addict (heroin methadone addicts) a pilot community study.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Community Mental Health Services; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Pilot Projects; Substance-Related Disorders | 1978 |
Behavioral effects of psychotherapeutic agents in rats chronically dosed with alpha-acetylmethadol.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Drug Interactions; Exploratory Behavior; Male; Methadone; Methadyl Acetate; Motor Activity; Postural Balance; Psychotropic Drugs; Rats; Time Factors | 1978 |
Recent developments in chemotherapy of narcotic addiction, 3-4 November 1977, Washington, D.C.: proceedings.
Topics: Animals; Congresses as Topic; Endorphins; Humans; Methadone; Methadyl Acetate; Narcotic Antagonists; New York; Receptors, Opioid; Societies, Scientific; Substance-Related Disorders | 1978 |
The binding of the optical isomers of methadone, alpha-methadol, alpha-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain.
Topics: Animals; Brain; Dealkylation; Hydromorphone; In Vitro Techniques; Isomerism; Methadone; Methadyl Acetate; Naloxone; Rats; Receptors, Drug | 1976 |
Dependence in rats after one injection of heroin-, LAAM- or hydromorphone-zinc tannate.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Heroin; Heroin Dependence; Humans; Hydromorphone; Methadone; Methadyl Acetate; Naloxone; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1979 |
The binding of LAAM and its metabolites to blood constituents.
Topics: Alpha-Globulins; Blood Proteins; Chromatography, Gel; Dialysis; Erythrocytes; Humans; Methadone; Methadyl Acetate; Molecular Weight; Protein Binding; Serum Albumin | 1979 |
Physiological disposition and biotransformation of l-alpha-[2-3H]acetylmethadol (LAAM) in acutely and chronically treated monkeys.
Topics: Animals; Behavior, Animal; Biotransformation; Blood Proteins; Feces; Female; Haplorhini; Macaca mulatta; Male; Methadone; Methadyl Acetate; Time Factors | 1978 |
The effect of ethanol on the metabolism of chronically-administered l-alpha-acetylmethadol (LAAM) in the rhesus monkey.
Topics: Animals; Behavior, Animal; Drug Interactions; Ethanol; Feces; Haplorhini; Macaca mulatta; Methadone; Methadyl Acetate; Time Factors | 1978 |
Carbon-13 nuclear magnetic resonance study of the alpha- and beta- isomers of methadol and acetylmethadol hydrochlorides.
Topics: Isomerism; Magnetic Resonance Spectroscopy; Methadone; Methadyl Acetate; Molecular Conformation; Solvents | 1978 |
Pharmacology of l-alpha-acetylmethadol (LAAM) in subhuman primates.
Topics: Administration, Oral; Animals; Behavior, Animal; Blood Proteins; Central Nervous System; Dealkylation; Haplorhini; Injections, Intravenous; Kinetics; Methadone; Methadyl Acetate; Protein Binding; Time Factors; Tissue Distribution | 1978 |
Levo-alpha-acetylmethadol: new drug for old habits.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Research | 1978 |
The SAODAP cooperative studies of LAAM: unblinded comparison with methadone.
Topics: Drug Administration Schedule; Government Agencies; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Substance Withdrawal Syndrome; United States; United States Food and Drug Administration | 1978 |
Phase III clinical study of LAAM: report of current status and analysis of early terminations.
Topics: Adolescent; Adult; Drug Administration Schedule; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts; United States | 1978 |
The future of LAAM.
Topics: Forecasting; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Personality; Psychotherapy; Social Adjustment | 1978 |
Interactions of acetylmethadol or methadone with other drugs in rhesus monkeys.
Topics: Animals; Cocaine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Haplorhini; Macaca mulatta; Male; Methadone; Methadyl Acetate; Reinforcement Schedule; Time Factors | 1979 |
Clinical experiences with repeated oral administration of l-alpha-acetylmethadol (LAAM) in the rhesus monkey.
Topics: Animals; Antipyrine; Body Temperature; Half-Life; Haplorhini; Heart Rate; Macaca mulatta; Male; Methadone; Methadyl Acetate; Respiration; Time Factors | 1978 |
Additional metabolic correlates of 1-alpha-acetylmethadol (LAAM)-induced cellular tolerance and physical dependence: the role of the hepatic microsomal electron transport system.
Topics: Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Tolerance; Electron Transport; Enzyme Induction; Humans; Methadone; Methadyl Acetate; Mice; Mice, Inbred ICR; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Opioid-Related Disorders; Proteins | 1979 |
Inhibition of the cytochrome P-450 multifunctional oxidase by N-propargyl analogs of SKF-525 A and acetylmethadol.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme Inhibitors; Female; Flavins; Flavoproteins; Fluorometry; Kinetics; Male; Methadone; Methadyl Acetate; Mixed Function Oxygenases; Oxidoreductases; Proadifen; Rabbits; Rats; Time Factors | 1979 |
Effects of chronic treatment with morphine, methadone, and LAAM on the response to phencyclidine in rats.
Topics: Animals; Behavior, Animal; Drug Synergism; Humans; Male; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Phencyclidine; Rats | 1979 |
The effect of l-alpha acetyl methadol in morphine-dependent rats.
Topics: Animals; Body Weight; Female; Humans; Injections, Intraperitoneal; Methadone; Methadyl Acetate; Morphine Dependence; Rats | 1979 |
General cardiovascular pharmacology of 1-alpha-acetylmethadol (LAAM).
Topics: Animals; Blood Pressure; Cats; Guinea Pigs; Heart Rate; Methadone; Methadyl Acetate; Myocardial Contraction; Rabbits; Rats | 1979 |
Estimation of 1-alpha(2-3H)acetylmethadol in biological materials and its separation from some metabolites and congeners on glass fibre sheets.
Topics: Chromatography, Gas; Chromatography, Thin Layer; Gels; Methadone; Methadyl Acetate; Methods; Silicon Dioxide; Solvents; Tritium | 1975 |
Extraction method and thin-layer chromatographic system for the determination of alpha-l-acetylmethadol and metabolites in biological fluids.
Topics: Animals; Bile Acids and Salts; Chromatography, Thin Layer; Gels; Haplorhini; Methadone; Methadyl Acetate; Silicon Dioxide; Tissue Extracts | 1976 |
The use of LAAM in treatment.
Topics: Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Individuality; Methadone; Methadyl Acetate; Psychology; United States; United States Substance Abuse and Mental Health Services Administration | 1976 |
1-alpha-acetylmethadol (LAAM), methadone and morphine abstinence in dependent rats: EEG and behavioral correlates.
Topics: Animals; Behavior, Animal; Electroencephalography; Electromyography; Female; Humans; Methadone; Methadyl Acetate; Morphine Dependence; Rats; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders | 1977 |
Transitional patterns of self-administration following substitution of methadone or l-alpha-acetylmethadol (LAAM) for morphine in dependent rats.
Topics: Animals; Electroencephalography; Electromyography; Humans; Male; Methadone; Methadyl Acetate; Morphine Dependence; Rats; Self Administration; Sleep, REM; Time Factors | 1978 |
Spontaneous vs. naloxone-induced abstinence in dependent rats self-administering L-alpha-acetylmethadol (LAAM) or morphine.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine Dependence; Naloxone; Rats; Self Administration; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1979 |
Pharmacodynamic profiles of 1-alpha-acetylmethadol (LAAM) and its N-demethylated metabolites, nor-LAAM and dinor-LAAM, during self-administration in the dependent rat.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Dealkylation; Dose-Response Relationship, Drug; Electroencephalography; Humans; Methadone; Methadyl Acetate; Rats; Self Administration; Sleep, REM; Substance-Related Disorders; Time Factors | 1979 |
Opioid self-administration and REM sleep EEG power spectra.
Topics: Animals; Electroencephalography; Female; Methadone; Methadyl Acetate; Morphine; Narcotics; Rats; Self Administration; Sleep, REM | 1979 |
Disposition of acetylmethadol in relation to pharmacologic action.
Topics: Adult; Biotransformation; Chromatography, Gas; Half-Life; Humans; Hydrogen-Ion Concentration; Kidney; Male; Methadone; Methadyl Acetate; Pupil; Substance-Related Disorders | 1975 |
Time-action and behavioral effects of amphetamine, ethanol, and acetylmethadol.
Topics: Animals; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Ethanol; Macaca mulatta; Male; Methadone; Methadyl Acetate; Time Factors | 1977 |
Clinical use of LAAM.
Topics: Adolescent; Adult; Drug Administration Schedule; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate | 1978 |
Chronic effects of acetylmethadol and methadone in rhesus monkeys.
Topics: Animals; Behavior, Animal; Blood; Blood Chemical Analysis; Cholesterol; Drug Administration Schedule; Enzymes; Haplorhini; Hematocrit; Hemoglobins; Liver; Liver Function Tests; Macaca mulatta; Methadone; Methadyl Acetate; Serum Albumin | 1977 |
Head-shake distributions during self-maintained dependence on morphine, methadone, and l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Animals; Behavior, Animal; Female; Humans; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Rats; Self Administration; Substance-Related Disorders | 1977 |
Self-administration of heroin, acetylmethadol, morphine, and methadone in rhesus monkeys.
Topics: Animals; Behavior, Animal; Haplorhini; Heroin; Injections, Intravenous; Macaca mulatta; Methadone; Methadyl Acetate; Morphine; Narcotics; Respiration; Self Administration | 1978 |
Severe toxicity and lethality in some monkeys following chronic administration of levo-alpha-acetylmethadol (LAAM).
Topics: Animals; Female; Haplorhini; Macaca mulatta; Male; Methadone; Methadyl Acetate; Nalorphine | 1977 |
The effects of acetylmethadol on motor activity and schedule-controlled responding.
Topics: Animals; Conditioning, Operant; Male; Methadone; Methadyl Acetate; Motor Activity; Rats; Reinforcement Schedule | 1979 |
Discriminative stimulus properties of levo-alpha-acetylmethadol and its metabolites.
Topics: Animals; Discrimination, Psychological; Male; Methadone; Methadyl Acetate; Morphine; Rats; Time Factors | 1979 |
Anti-cholinesterase activity of 1-alpha-acetylmethadol: relationship to bradycardia.
Topics: Acetylcholinesterase; Animals; Bethanechol Compounds; Bradycardia; Butyrylcholinesterase; Cholinesterase Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Methadone; Methadyl Acetate; Morphine; Myocardium; Physostigmine | 1979 |
The quantitative analysis of 1-alpha-acetylmethadol and its principal metabolites in biological specimens by gas chromatography-chemical ionization-multiple ion monitoring mass spectrometry.
Topics: Bile; Brain Chemistry; Chromatography, Gas; Feces; Humans; Liver; Mass Spectrometry; Methadone; Methadyl Acetate | 1979 |
Modification of hepatic microsomal oxidative drug metabolism in rats by the opiate maintenance drugs acetylmethadol, propoxyphene, and methadone.
Topics: Animals; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Male; Methadone; Methadyl Acetate; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship | 1979 |
Naloxone-precipitated jumping in mice pretreated with acute injections of opioids.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Enkephalins; Heroin; Male; Methadone; Methadyl Acetate; Mice; Morphine; Naloxone; Narcotics; Pentazocine | 1979 |
Cardiac effects of 1-alpha-acetylmethadol (LAAM) in different species.
Topics: Animals; Calcium; Depression, Chemical; Drug Interactions; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Methadone; Methadyl Acetate; Myocardial Contraction; Pregnancy; Rabbits; Rats; Species Specificity | 1979 |
Cardiac effects of 1-alpha-acetylmethadol. V. Possible involvement of the autonomic nervous system.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Heart; Heart Rate; Hydroxydopamines; Methadone; Methadyl Acetate; Myocardial Contraction; Sympathetic Nervous System; Vagotomy | 1979 |
Effectiveness of psychotherapeutic counseling in methadone maintenance.
Topics: Counseling; Double-Blind Method; Humans; Methadone; Methadyl Acetate; Narcotics; Opioid-Related Disorders; Psychotherapy; Psychotherapy, Group | 1979 |
Levo-alpha-acetylmethadol (LAAM) in the treatment of heroin addicts. I. Dosage schedule for induction and stabilization.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged | 1979 |
Effects observed during subchronic administration of l-alpha-acetylmethadol (LAAM) to guinea pigs.
Topics: Animals; Body Weight; Eating; Electroencephalography; Female; Guinea Pigs; Heart Rate; Male; Methadone; Methadyl Acetate | 1979 |
Tolerance and cross tolerance to toxic effects of morphine, methadone and 1-alpha-acetylmethadol (LAAM) in naive and morphine dependent rats.
Topics: Animals; Cross Reactions; Drug Tolerance; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Substance-Related Disorders | 1978 |
Development of cellular tolerance to lethality and analgesia concurrent with physical dependence following repeated oral administration of LAAM.
Topics: Administration, Oral; Animals; Drug Tolerance; Humans; Injections, Intraventricular; Lethal Dose 50; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred ICR; Morphine; Naloxone; Nociceptors; Opioid-Related Disorders | 1979 |
Problems of methadone diversion and implications for control.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Time Factors | 1977 |
LAAM--a long-acting methadone.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate | 1978 |
Effect of 1-alpha-acetylmethadol (LAAM) on various physiological parameters in the conscious dog.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Male; Methadone; Methadyl Acetate; Respiration | 1978 |
Effect of autonomic blocking agents on chronotropic actions of 1-alpha-acetylmethadol.
Topics: Animals; Atropine; Autonomic Agents; Dogs; Drug Interactions; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Methacholine Compounds; Methadone; Methadyl Acetate; Physostigmine; Propranolol | 1978 |
Uptake, metabolism and efflux of l-alpha-acetylmethadol (LAAM) by rat lung tissue.
Topics: Animals; Biological Transport, Active; In Vitro Techniques; Kinetics; Lung; Male; Methadone; Methadyl Acetate; Rats | 1978 |
Microsomal enzyme induction following repeated oral administration of LAAM.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Body Weight; Dogs; Enzyme Induction; Male; Methadone; Methadyl Acetate; Methyltransferases; Mice; Mice, Inbred ICR; Microsomes, Liver; Organ Size; Pentobarbital; Sleep; Time Factors | 1978 |
Behavioral effects of chronic oral administration of levo-alpha-acetylmethadol in the rat.
Topics: Administration, Oral; Animals; Behavior, Animal; Body Weight; Drinking Behavior; Methadone; Methadyl Acetate; Rats; Time Factors | 1978 |
Cardiac effects of 1-alpha-acetylmethadol. IV. Mechanism of inotropic effects.
Topics: Animals; Calcium; Depression, Chemical; Dopamine; Guinea Pigs; In Vitro Techniques; Methadone; Methadyl Acetate; Myocardial Contraction; Propranolol; Stimulation, Chemical | 1978 |
levo-Alpha-acetylmethadol and metabolites: some effects on schedule-controlled behavior in the rat.
Topics: Animals; Behavior, Animal; Male; Methadone; Methadyl Acetate; Morphine; Rats; Reinforcement Schedule; Time Factors | 1978 |
Mass fragmentographic determination of methadyl acetate in urine using stable isotope labeled analog as internal standard.
Topics: Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Isotope Labeling; Methadone; Methadyl Acetate; Rabbits | 1978 |
Interaction toxicity between ethanol and narcotics in mice with reference to alpha-1-acetylmethadol (LAAM).
Topics: Animals; Brain; Dextrorphan; Drug Interactions; Ethanol; Lethal Dose 50; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Morphine; Narcotics | 1978 |
[OH]- negative chemical ionization mass spectrometry. Reactions of [OH]- with methadone, l-alpha-acetylmethadol and their metabolites.
Topics: Anions; Free Radicals; Humans; Hydroxides; Mass Spectrometry; Methadone; Methadyl Acetate | 1978 |
A computer feedback system for clinical research.
Topics: Computers; Demography; Feedback; Filing; Heroin Dependence; Humans; Information Systems; Medical History Taking; Methadone; Methadyl Acetate; Socioeconomic Factors; Surveys and Questionnaires | 1979 |
LAAM bibliography: preclinical.
Topics: Animals; Bibliographies as Topic; Drug Evaluation, Preclinical; Methadone; Methadyl Acetate | 1976 |
LAAM bibliography: clinical.
Topics: Bibliographies as Topic; Drug Evaluation; Humans; Methadone; Methadyl Acetate | 1976 |
1-alpha-acetylmethadol(LAAM) pharmacokinetics and metabolism: current status.
Topics: Administration, Oral; Animals; Behavior; Brain; Female; Haplorhini; Humans; Injections, Intramuscular; Injections, Subcutaneous; Kinetics; Methadone; Methadyl Acetate; Muscle Contraction; Rats; Species Specificity; Time Factors | 1975 |
Evaluation of narcotic and narcotic antagonist interactions in primates.
Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration | 1976 |
Plasma l-alpha-Acetylmethadol (LAAM) after acute and chronic administration.
Topics: Adult; Chromatography, Gas; Half-Life; Heroin Dependence; Humans; Kinetics; Male; Methadone; Methadyl Acetate; Middle Aged; Time Factors | 1977 |
Metabolism and probable active metabolite of alpha-l-acetylmethadol in rat.
Topics: Animals; Chromatography, Gas; Dealkylation; Liver; Male; Methadone; Methadyl Acetate; Oxidation-Reduction; Rats | 1977 |
Simultaneous determination of acetylmethadol and its major metabolites by gas-liquid chromatography.
Topics: Alkalies; Chromatography, Gas; Chromatography, Liquid; Hydrolysis; Methadone; Methadyl Acetate | 1977 |
Cardiac effects of 1-alpha-acetylmethadol. I. Chronotropic effects in vitro.
Topics: Animals; Drug Interactions; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Methacholine Compounds; Methadone; Methadyl Acetate; Morphine; Naloxone; Norepinephrine | 1977 |
Inotropic effects of 1-alpha-acetylmethadol (LAAM).
Topics: Animals; Drug Interactions; Guinea Pigs; In Vitro Techniques; Methadone; Methadyl Acetate; Myocardial Contraction; Norepinephrine; Ouabain | 1977 |
Failure of methadone and levomethadyl acetate (levo-alpha-acetylmethadol, LAAM) maintenance to affect memory.
Topics: Adult; Amphetamines; Barbiturates; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Male; Memory; Methadone; Methadyl Acetate; Opium; Psychological Tests; Research Design; Time Factors | 1977 |
Inhibition of growth in young mice treated with d,1-methadone.
Topics: Animals; Animals, Newborn; Appetite Depressants; Body Weight; Depression, Chemical; Drug Tolerance; Female; Growth; Levallorphan; Methadone; Methadyl Acetate; Mice; Nalorphine; Naloxone; Reaction Time; Stereoisomerism; Time Factors | 1977 |
Calcium antagonist activity of methadone, l-acetylmethadol and l-pentazocine in the rat aortic strip.
Topics: Animals; Aorta, Thoracic; Calcium; Drug Interactions; In Vitro Techniques; Male; Methadone; Methadyl Acetate; Morphine; Muscle Contraction; Muscle, Smooth; Pentazocine; Rats; Stereoisomerism | 1977 |
Brain levels of l-alpha--acetylmethadol (LAAM) and metabolites in the rat: correlation with pharmacological effects.
Topics: Analgesics; Animals; Body Temperature; Brain; Female; Male; Methadone; Methadyl Acetate; Rats; Time Factors | 1977 |
Effect of alteration of metabolism on the analgesic activity, toxicity, distribution and excretion of l-alpha-acetylmethadol in the rat.
Topics: Analgesics; Animals; Bile; Feces; Lethal Dose 50; Liver; Male; Methadone; Methadyl Acetate; Phenobarbital; Rats; Tissue Distribution | 1977 |
The effect of alpha-1-acetylmethadol hydrochloride on rat hepatic aryl hydrocarbon hydroxylase and epoxide hydrase.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Female; In Vitro Techniques; Male; Methadone; Methadyl Acetate; Microsomes, Liver; Motor Activity; Rats; Stimulation, Chemical | 1977 |
Pharmacotherapy of opiate addiction.
Topics: Adolescent; Adult; Cyclazocine; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Naltrexone; Opium; Substance-Related Disorders; United States | 1976 |
l-Alpha-acetylmethadol (LAAM): prognostic considerations.
Topics: Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; MMPI; Psychopathology; Social Adjustment | 1976 |
Therapeutic effects of methadone and 1-alpha-acetylmethadol.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate | 1976 |
Synthesis of (-)-alpha-acetylmethadol metabolites and related compounds.
Topics: Methadone; Methadyl Acetate; Methods | 1976 |
The chemistry of LAAM.
Topics: Chemical Phenomena; Chemistry; Chromatography, Gas; Drug Stability; Methadone; Methadyl Acetate; Stereoisomerism | 1976 |
A clinical experience with LAAM.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Self Administration; Substance Withdrawal Syndrome; Time Factors | 1976 |
1-Alpha-acetylmethoadol in the treatment of opiate addiction: progress report. 1971 [proceedings].
Topics: Drug Evaluation; Female; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts; Substance-Related Disorders | 1976 |
1-Alpha-acetylmethadol (LAM): comparison of laboratory findings, electroencephalograms, and Cornell Medical Index of patients stabilized on LAM with those on methadone. 1972 [proceedings].
Topics: Adult; Blood Glucose; Cornell Medical Index; Electroencephalography; Female; Humans; Male; Methadone; Methadyl Acetate; Substance-Related Disorders | 1976 |
Actions and addiction liabilities of alpha-acetylmethadols in man. 1952 [proceedings].
Topics: Adult; Drug Administration Schedule; Humans; Male; Methadone; Methadyl Acetate; Miotics; Morphine Dependence; Substance Withdrawal Syndrome; Substance-Related Disorders | 1976 |
LAAM and LAAM metabolites: plasma levels in patients. Summary progress report. 1975 [proceedings].
Topics: Humans; Methadone; Methadyl Acetate; Substance-Related Disorders; Time Factors | 1976 |
Pharmacodynamics of LAAM in man: plasma levels of LAAM and its metabolites following acute and chronic administration in man (fourth and sixth quarter progress reports). 1974-5 [proceedings].
Topics: Drug Administration Schedule; Humans; Kinetics; Male; Methadone; Methadyl Acetate; Substance-Related Disorders | 1976 |
Simultaneous determination of acetyl-methadol and its active biotransformation products in human biofluids. 1975 [proceedings].
Topics: Biotransformation; Body Fluids; Humans; Methadone; Methadyl Acetate | 1976 |
Disposition of acetylmethadol in relation to pharmacological activity. 1975 [proceedings].
Topics: Adult; Half-Life; Humans; Male; Methadone; Methadyl Acetate; Pupil; Substance-Related Disorders; Time Factors | 1976 |
Levomethadyl acetate: prolonged duration of opioid effects, including cross tolerance to heroin, in man. 1973 [proceedings].
Topics: Adult; Drug Tolerance; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Substance Withdrawal Syndrome; Time Factors | 1976 |
Levomethadyl in maintenance treatment of opiate dependence. 1972 [proceedings].
Topics: Drug Administration Schedule; Drug Evaluation; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate | 1976 |
Comparative study on the derivatization of l-alpha-acetyl-methadol metabolites for electron capture gas-liquid chromatography.
Topics: Chromatography, Gas; Chromatography, Liquid; Humans; Indicators and Reagents; Methadone; Methadyl Acetate; Methods | 1976 |
The use of l-alpha-acetylmethadol in treatment of heroin addiction: an open study.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged | 1976 |
Failure of acetylmethadol in treatment of narcotic addicts due to nonpharmacologic factors.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Patient Dropouts | 1976 |
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorphanol; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1976 |
1-Acetylmethadol (LAM) treatment of opiate dependence: plasma and urine levels of two pharmacologically active metabolites, 1974.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate | 1976 |
Simultaneous determination of acetylmethadol and its active riotransformation products in human biofluids.
Topics: Biotransformation; Chromatography, Gas; Humans; Mass Spectrometry; Methadone; Methadyl Acetate; Methods; Spectrum Analysis; Time Factors | 1975 |
Synthesis of alpha-1-noracetylmethadol. A facile N-demethylation of alpha-1-acetylmethadol.
Topics: Animals; Dealkylation; Methadone; Methadyl Acetate; Mice; Pain; Reaction Time | 1975 |
Renal toxicity of l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Animals; Hematuria; Kidney Diseases; Kidney Tubules; Methadone; Methadyl Acetate; Morphine; Naloxone; Nephrosis; Phenobarbital; Rats; Time Factors | 1975 |
Duration of antinociceptive action of morphine, methadone and alpha-l-acetylmethadol subcutaneously in rats.
Topics: Analgesia; Animals; Injections, Subcutaneous; Male; Methadone; Methadyl Acetate; Morphine; Rats; Reaction Time; Time Factors; Vocalization, Animal | 1975 |
On the role of chemotherapy in the treatment of heroin addiction.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Motivation; Naloxone; Naltrexone; Substance-Related Disorders | 1975 |
Implementing a national study of a new maintenance drug.
Topics: Administration, Oral; Attitude of Health Personnel; Drug Evaluation; Drug Evaluation, Preclinical; Heroin Dependence; Humans; Informed Consent; Methadone; Methadyl Acetate; Patient Compliance; Research Design; United States; United States Food and Drug Administration | 1975 |
l-alpha-acetylmethadol and methadone in Buffalo: safety and efficacy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Attitude of Health Personnel; Drug Evaluation; Heroin Dependence; Hostility; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; New York; Patient Compliance; Patient Dropouts; Substance Withdrawal Syndrome | 1975 |
Methadone and l-alpha-acetylmethadol in a treatment program in Brooklyn.
Topics: Adult; Aged; Consumer Behavior; Drug Evaluation; Employment; Ethnicity; Heroin Dependence; Hostility; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; New York City; Patient Dropouts; Reward; United States; United States Food and Drug Administration | 1975 |
LAAM (l-alpha-acetylmethadol) study in St. Louis.
Topics: Adolescent; Adult; Age Factors; Blood Pressure; Brain; Drug Evaluation; Evoked Potentials; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Missouri; Patient Compliance; Patient Dropouts; Research; Substance Withdrawal Syndrome; Time Factors; Visual Perception | 1975 |
Patient deaths in a narcotic antagonist (naltrexone) and l-alpha-acetylmethadol program.
Topics: Adult; Heroin Dependence; Homicide; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Naltrexone; Psychotropic Drugs; Substance-Related Disorders; Suicide | 1975 |
Stereotypy following acute administration of l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Amphetamine; Animals; Apomorphine; Behavior; Drug Interactions; Haloperidol; Humans; Male; Methadone; Methadyl Acetate; Methyltyrosines; Naloxone; Rats; Stereotyped Behavior | 1975 |
Effects of acetylmethadol on plasma testosterone.
Topics: Adult; Biotransformation; Depression, Chemical; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Testosterone; Time Factors | 1976 |
NIDA's Medication Development Program--1989.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cocaine; Drug and Narcotic Control; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Methadyl Acetate; Naltrexone; Pregnancy; Psychotropic Drugs; Research Support as Topic; Risk Factors; Substance Abuse, Intravenous; Substance-Related Disorders | 1989 |
Divided dose for methadone maintenance patients.
Topics: Adrenergic alpha-Agonists; Drug Administration Schedule; Drug Therapy, Combination; Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders | 1988 |
Neurotoxicity of opiates during brain development: in vivo and in vitro studies.
Topics: Abnormalities, Drug-Induced; Animals; Binding Sites; Brain; Cells, Cultured; Chick Embryo; Etorphine; In Vitro Techniques; Methadone; Methadyl Acetate; Neurons; Receptors, Opioid; Tritium | 1985 |
In vivo carcinogenesis assay of L-alpha-acetylmethadol.HCl in rodents.
Topics: Animals; Carcinogenicity Tests; Eating; Female; Lethal Dose 50; Male; Methadone; Methadyl Acetate; Mice; Mice, Inbred Strains; Neoplasms; Rats; Rats, Inbred F344 | 1988 |
Clinical experiences with 959 opioid-dependent patients treated with levo-alpha-acetylmethadol (LAAM).
Topics: Adolescent; Adult; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders | 1986 |
Variability in simian motor and social behavior with alternating-day acetylmethadol.
Topics: Animals; Circadian Rhythm; Humans; Macaca radiata; Male; Methadone; Methadyl Acetate; Motor Activity; Social Behavior; Substance Withdrawal Syndrome; Time Factors | 1985 |
Acetylmethadol versus methadone: human mood and motility.
Topics: Adult; Emotions; Humans; Interpersonal Relations; Male; Methadone; Methadyl Acetate; Motor Activity; Sexual Behavior | 1985 |
Effect of phenobarbital pretreatment on the plasma and urinary levels of (-)-alpha-acetylmethadol and its metabolites.
Topics: Animals; Biotransformation; Chromatography, Thin Layer; Injections, Intraperitoneal; Male; Methadone; Methadyl Acetate; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Quantitation of l-alpha-acetylmethadol and its metabolites in human serum by capillary gas-liquid chromatography and nitrogen detection.
Topics: Chromatography, Gas; Drug Stability; Humans; Methadone; Methadyl Acetate; Time Factors | 1985 |
Comparative cardiac contractile actions of six narcotic analgesics: morphine, meperidine, pentazocine, fentanyl, methadone and l-alpha-acetylmethadol (LAAM).
Topics: Analgesics, Opioid; Animals; Cats; Depression, Chemical; Drug Interactions; Fentanyl; Meperidine; Methadone; Methadyl Acetate; Morphine; Myocardial Contraction; Naloxone; Pentazocine; Stimulation, Chemical | 1980 |
Occurrence of corneal opacities in rats after acute administration of l-alpha-acetylmethadol.
Topics: Analgesics, Opioid; Animals; Cornea; Corneal Opacity; Dose-Response Relationship, Drug; Male; Methadone; Methadyl Acetate; Morphine; Pupil; Rats | 1980 |
(-)-alpha-Acetylmethadol for treatment of chronic pain patients who abuse opioids.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders; Pain | 1983 |
Zinc tannate salts of heroin, LAAM and hydromorphone attenuate opiate withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Codeine; Delayed-Action Preparations; Heroin; Humans; Hydromorphone; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Rats; Substance Withdrawal Syndrome; Zinc | 1980 |
Binding of 1-alpha-acetylmethadol and its metabolites to blood constituents.
Topics: Alpha-Globulins; Blood Proteins; Dialysis; Erythrocytes; Humans; Methadone; Methadyl Acetate; Molecular Weight; Narcotics; Protein Binding; Time Factors | 1980 |
Continuous exposure of the chick embryo to l-alpha-noracetylmethadol does not alter brain protein or nucleic acid content.
Topics: Animals; Brain; Chick Embryo; DNA; Methadone; Methadyl Acetate; Nerve Tissue Proteins; Organ Size; RNA | 1981 |
Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Cebus; Female; Macaca mulatta; Male; Methadone; Methadyl Acetate; Receptors, Opioid | 1981 |
Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists.
Topics: Animals; Chemical Phenomena; Chemistry; Methadone; Methadyl Acetate; Mice; Narcotic Antagonists; Narcotics; Receptors, Opioid | 1981 |
Addressing the diversion of take-home methadone: LAAM as the sole treatment choice for patients seeking maintenance therapy.
Topics: Ambulatory Care; Female; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Sex Factors | 1983 |
Methadone maintenance: an update.
Topics: Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders | 1983 |
Various factors which affect the rate of development of tolerance and physical dependence to abused drugs.
Topics: Animals; Body Weight; Drug Tolerance; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Reaction Time; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors | 1984 |
Genetic screening of compounds used in drug abuse treatment. III. LAAM.
Topics: Animals; Bone Marrow Cells; DNA Repair; Drug Evaluation, Preclinical; Escherichia coli; Humans; In Vitro Techniques; Lymphoma; Methadone; Methadyl Acetate; Mice; Mutagens; Neoplasms, Experimental; Neurospora crassa; Salmonella typhimurium; Substance-Related Disorders | 1981 |
Dopaminergic and cholinergic muscarinic receptor effects of L-alphacetylmethadol (LAAM) and its metabolites.
Topics: Animals; Atropine; Kinetics; Male; Methadone; Methadyl Acetate; Myocardium; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Muscarinic; Spiperone | 1984 |
Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate.
Topics: Animals; Dose-Response Relationship, Drug; Escape Reaction; Female; Humans; Male; Methadone; Methadyl Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reaction Time; Substance Withdrawal Syndrome | 1984 |
Episodes of heroin use during maintenance treatment with stable dosage of (-)-alpha-acetylmethadol (methadyl acetate, LAAM).
Topics: Family; Heroin; Heroin Dependence; Humans; Life Style; Methadone; Methadyl Acetate; Recurrence | 1983 |
Effects of N-LAAM on [3H]etorphine binding in neuronal-enriched cell cultures.
Topics: Animals; Binding Sites; Brain; Cells, Cultured; Chick Embryo; Etorphine; Guanosine Triphosphate; Magnesium; Methadone; Methadyl Acetate; Morphinans; Narcotics; Neurons; Sodium; Tritium | 1983 |
Effects of heroin, methadone, LAAM and cyclazocine on acquisition and performance of response sequences in monkeys.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Erythrocebus patas; Female; Heroin; Methadone; Methadyl Acetate; Narcotics; Serial Learning | 1983 |
(--)-alpha-Acetylmethadol effects on alcohol and diazepam use, sexual function and cardiac function.
Topics: Adult; Alcohol Drinking; Blood Pressure; Diazepam; Electrocardiography; Heart; Heart Rate; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Sexual Behavior; Substance-Related Disorders | 1983 |
Opiate withdrawal increases ornithine decarboxylase activity which is otherwise unaltered in brains of dependent chicken fetuses.
Topics: Animals; Brain; Carboxy-Lyases; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Ornithine Decarboxylase; Substance Withdrawal Syndrome | 1983 |
Separation of hepatic N-demethylase-inducing and opioid dependence-producing doses of levo-alpha-acetylmethadol in the pregnant rat.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Embryo Implantation; Ethylmorphine-N-Demethylase; Female; Fetal Resorption; Humans; Methadone; Methadyl Acetate; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Substance-Related Disorders | 1983 |
Plasma testosterone and luteinizing hormone levels during levo-alpha-acetylmethadol maintenance and withdrawal.
Topics: Adult; Humans; Luteinizing Hormone; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Pituitary Gland; Radioimmunoassay; Substance Withdrawal Syndrome; Testosterone | 1984 |
[Pharmacotherapeutic aspects of aid to heroin addicts].
Topics: Heroin Dependence; Humans; Inactivation, Metabolic; Methadone; Methadyl Acetate | 1984 |
L-alpha-acetylmethadol-induced tissue alterations in mice.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Glutathione; Kidney; Liver; Male; Methadone; Methadyl Acetate; Methylcholanthrene; Mice; Mice, Inbred ICR; Necrosis; Phenobarbital; Time Factors | 1984 |
Modification of drug effects by l-alpha-acetylmethadol.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Methadone; Methadyl Acetate; Morphine; Pentobarbital; Phencyclidine; Rats; Rats, Inbred Strains | 1984 |
Pharmacokinetics and metabolism of l-alpha-[O,O'-3H2]-acetyl normethadol (nor-LAAM), the active metabolite of LAAM, in acutely and chronically treated rhesus monkeys.
Topics: Administration, Oral; Animals; Behavior, Animal; Biological Availability; Biotransformation; Haplorhini; Injections, Intravenous; Kinetics; Macaca mulatta; Methadone; Methadyl Acetate; Time Factors | 1980 |
Effects of levo-alpha-acetylmethadol (LAAM) on morphine self-administration in the rat.
Topics: Animals; Electroencephalography; Female; Methadone; Methadyl Acetate; Morphine; Rats; Self Administration; Sleep, REM | 1981 |
Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM).
Topics: Animals; Animals, Newborn; Carbon Dioxide; Chloral Hydrate; Dogs; Female; Humans; Methadone; Methadyl Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Respiration; Sleep; Substance Withdrawal Syndrome; Time Factors | 1982 |
Withdrawal from heroin in three or six weeks: comparison of LAAM versus methadone.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Time Factors | 1982 |
LAAM instead of take-home methadone.
Topics: Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders | 1982 |
Postnatal abstinence or acute toxicity can account for morbidity in developmental studies with opiates.
Topics: Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Male; Methadone; Methadyl Acetate; Naloxone; Pregnancy; Rats; Rats, Inbred Strains | 1983 |
Isotope dilution technique for the estimation of l-alpha-[2-3H]-acetylmethadol and its metabolites in biological samples.
Topics: Animals; Biotransformation; Chromatography, Gas; Chromatography, Thin Layer; Female; Liver; Methadone; Methadyl Acetate; Pregnancy; Radioisotope Dilution Technique; Rats; Scintillation Counting | 1980 |
Cumulation of active metabolites of levo-alpha-acetylmethadol in the rat fetus and neonate.
Topics: Animals; Animals, Newborn; Brain; Female; Fetus; Maternal-Fetal Exchange; Methadone; Methadyl Acetate; Pregnancy; Rats; Rats, Inbred Strains | 1982 |
Heroin addict responses to six weeks of detoxification with LAAM.
Topics: Adult; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts; Social Adjustment; Substance Withdrawal Syndrome | 1982 |
Hepatic glutathione and hepatotoxicity: effects of cytochrome P-450 complexing compounds SKF 525-A, L-alpha acetylmethadol (LAAM), norLAAM, and piperonyl butoxide.
Topics: Alanine Transaminase; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; Liver; Male; Mesocricetus; Methadone; Methadyl Acetate; Mice; Mixed Function Oxygenases; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains | 1982 |
Cardiac and autonomic nervous system effects of L-alphacetylmethadol (LAAM).
Topics: Animals; Atropine; Autonomic Nervous System; Blood Pressure; Calcium; Drug Interactions; Electric Stimulation; Guinea Pigs; Heart; In Vitro Techniques; Male; Methadone; Methadyl Acetate; Naltrexone; Norepinephrine | 1982 |
Narcotic abstinence in dependent rats: EEG and behavioral correlates.
Topics: Animals; Behavior, Animal; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Sleep, REM; Substance Withdrawal Syndrome | 1980 |
A method for determining cumulative behavioral toxicity after chronic oral administration of l-alpha-acetylmethadol to female rats.
Topics: Administration, Oral; Animals; Behavior, Animal; Drug Tolerance; Female; Fetus; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; Substance-Related Disorders | 1980 |
Opiate withdrawal in utero increases neonatal morbidity in the rat.
Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; Methadyl Acetate; Naloxone; Opioid-Related Disorders; Pregnancy; Pregnancy, Animal; Rats; Substance Withdrawal Syndrome | 1981 |
Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
Topics: Animals; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1981 |
Morphine challenges in levo-alpha-acetylmethadol (LAAM) post-addict rats.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders; Wakefulness | 1981 |
Stereotypy and striatal dopamine receptor changes with 1-alpha-acetylmethadol (LAAM).
Topics: Animals; Corpus Striatum; Humans; Male; Methadone; Methadyl Acetate; Mice; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Time Factors | 1981 |
Relapse to morphine self-administration in morphine, methadone, and levo-alpha-acetylmethadol (LAAM) post-addict rats.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine Dependence; Rats; Self Administration; Sleep, REM; Substance-Related Disorders | 1981 |
Outcome of pregnancy in rats chronically exposed to 1-alpha-acetylmethadol (LAAM).
Topics: Animals; Animals, Newborn; Birth Weight; Body Weight; Female; Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders; Pregnancy; Pregnancy, Animal; Rats; Time Factors | 1981 |
Differential electroencephalographic and behavioral cross tolerance to morphine and methadone in the l-alpha-acetylmethadol (LAAM)-maintained rat.
Topics: Animals; Behavior, Animal; Drug Tolerance; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Rats; Rats, Inbred Strains | 1982 |
Sex and age dependence of the "selective" induction of rat hepatic microsomal epoxide hydratase following trans-stilbene oxide, l-alpha-acetylmethadol, or phenobarbital treatment.
Topics: Age Factors; Animals; Benzopyrene Hydroxylase; Enzyme Induction; Epoxide Hydrolases; Female; Male; Methadone; Methadyl Acetate; Microsomes, Liver; Phenobarbital; Rats; Sex Factors; Stilbenes | 1980 |
Determination of acetylmethadol and metabolites by use of high-performance liquid chromatography.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Rats; Sheep | 1981 |
l-alpha-Acetylmethadol (LAAM) attenuates sympathetic function by a peripheral mechanism.
Topics: Animals; Blood Pressure; Cats; Heart Rate; Methadone; Methadyl Acetate; Nictitating Membrane; Peripheral Nerves; Sympathetic Nervous System | 1981 |
Heroin and chromosome damage.
Topics: Adult; Chromosome Aberrations; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate | 1980 |
Enterohepatic circulation of l-alpha-acetylmethadol in the rat.
Topics: Animals; Bile; Enterohepatic Circulation; Male; Methadone; Methadyl Acetate; Rats; Time Factors; Tissue Distribution | 1980 |
Comparative study of the electroencephalographic and behavioral effects of l-alpha-acetylmethadol (LAAM), two of its metabolites and morphine and methadone in the rat.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electrocardiography; Female; Methadone; Methadyl Acetate; Morphine; Rats | 1980 |
Stereospecific radioimmunoassay of alpha-l-acetylmethadol (LAAM).
Topics: Animals; Dogs; Female; Hypothermia; Methadone; Methadyl Acetate; Rabbits; Radioimmunoassay | 1980 |
A clinical, controlled study of l-alpha-acetylmethadol in the treatment of narcotic addiction.
Topics: Adult; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Outcome and Process Assessment, Health Care | 1981 |
Follow-up study of subjects on methadyl acetate and methadone.
Topics: Alcohol Drinking; California; Double-Blind Method; Employment; Follow-Up Studies; Heroin Dependence; Humans; Interpersonal Relations; Methadone; Methadyl Acetate; Social Adjustment | 1980 |
Immunoglobulin levels in heroin addicts after treatment with methadone and methadyl acetate.
Topics: Adult; Heroin Dependence; Humans; Immunoglobulins; Methadone; Methadyl Acetate; Middle Aged | 1980 |
The effects of levo-alpha-acetylmethadol and its metabolites on schedule-controlled behavior in the pigeon.
Topics: Animals; Behavior, Animal; Columbidae; Drug Tolerance; Methadone; Methadyl Acetate; Naloxone; Structure-Activity Relationship | 1981 |
[Current status and prospectives of combating addiction of heroin].
Topics: Buprenorphine; Clonidine; Heroin Dependence; Humans; Methadone; Methadyl Acetate | 1995 |
[Role of LAAM, methadone and naltrexone in the care of opiate dependence. Experience in Portugal].
Topics: Drug Administration Schedule; Female; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Naltrexone; Narcotics; Patient Compliance; Portugal; Substance-Related Disorders; Time Factors | 1994 |
Position statement on methadone maintenance treatment.
Topics: Buprenorphine; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Practice Guidelines as Topic; Psychiatry; Societies, Medical; United States | 1994 |
Discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), buprenorphine and methadone in morphine-treated rhesus monkeys.
Topics: Animals; Buprenorphine; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Naltrexone; Narcotic Antagonists; Narcotics | 1997 |
l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog.
Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Methadone; Methadyl Acetate; Morphine; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1997 |
The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dimethylamines; DNA, Complementary; Enzyme Inhibitors; Humans; Isoenzymes; Methadone; Methadyl Acetate; Microsomes, Liver; Mixed Function Oxygenases; Substrate Specificity | 1997 |
Incorporation of drugs for the treatment of substance abuse into pigmented and nonpigmented hair.
Topics: Animals; Area Under Curve; Buprenorphine; Chromatography, Liquid; Hair; Male; Mass Spectrometry; Methadone; Methadyl Acetate; Narcotics; Patient Compliance; Rats; Substance-Related Disorders | 1998 |
Detection of methadone, LAAM, and their metabolites by methadone immunoassays.
Topics: Cross Reactions; Dose-Response Relationship, Drug; Fluorescence Polarization Immunoassay; Humans; Immunoenzyme Techniques; Immunosorbent Techniques; In Vitro Techniques; Methadone; Methadyl Acetate; Radioimmunoassay; Urine | 1999 |
Treating opioid dependence--new data and new opportunities.
Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders | 2000 |
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
Topics: Algorithms; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Humans; Intestinal Mucosa; Intestines; Isoenzymes; Kinetics; Methadone; Methadyl Acetate; Microsomes; Mixed Function Oxygenases; Narcotics | 2001 |
Maintenance therapy for opioid addiction with methadone, LAAM and buprenorphine: the Emperor's New Clothes Phenomenon.
Topics: Buprenorphine; Electrocardiography; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Time Factors | 2001 |
Which substitution pharmacotherapy is most effective in treating opioid dependence?
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Methadyl Acetate; Opioid-Related Disorders | 2002 |
The use of levo-alpha-acetylmethadol (LAAM) in methadone patients who have not achieved heroin abstinence.
Topics: Adrenocorticotropic Hormone; Adult; Biological Availability; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Heroin Dependence; Humans; Hydrocortisone; Male; Metabolic Clearance Rate; Methadone; Methadyl Acetate; Narcotics; Patient Acceptance of Health Care; Pilot Projects; Prolactin; Substance Abuse Detection | 2002 |
Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Heroin; Male; Methadone; Methadyl Acetate; Rats; Reaction Time; Stereoisomerism | 2002 |
Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents.
Topics: Cation Transport Proteins; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Methadone; Methadyl Acetate; Narcotics; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Voltage-Gated; Trans-Activators; Transcriptional Regulator ERG; Transfection | 2002 |
Clinical treatment of opioid addiction and dependence.
Topics: Administration, Oral; Administration, Sublingual; Buprenorphine; Humans; Inactivation, Metabolic; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders | 2003 |
Synthetic analgesics: III. Methadols, isomethadols, and their acyl derivatives.
Topics: Analgesics; Methadone; Methadyl Acetate | 1954 |
[Substitutions therapy of opiate addiction in Denmark].
Topics: Benzodiazepines; Buprenorphine; Denmark; Humans; Methadone; Methadyl Acetate; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Surveys and Questionnaires | 2003 |
Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Comorbidity; Cross-Sectional Studies; Female; Health Services; Health Services Needs and Demand; Humans; Hypnotics and Sedatives; Illicit Drugs; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Opioid-Related Disorders; Pain; Pain Measurement; Statistics as Topic; Substance-Related Disorders; United States; Utilization Review; Veterans | 2004 |
Analgesic activity and toxic effects of acetylmethadol isomers in man.
Topics: Analgesics; Humans; Isomerism; Male; Methadone; Methadyl Acetate | 1952 |
Actions and addiction liabilities of alpha-acetyl-methadols in man.
Topics: Behavior, Addictive; Methadone; Methadyl Acetate | 1952 |
Serious adverse events in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD).
Topics: Adult; Analgesics, Opioid; Australia; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Methadyl Acetate; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders | 2004 |
Comments on Ritter et al.'s report of a comparative trial of LAAM and methadone maintenance.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Narcotics; Patient Compliance | 2004 |
Diffusion of substance abuse treatment: will buprenorphine be a success?
Topics: Buprenorphine; Heroin Dependence; Humans; Methadone; Methadyl Acetate; Narcotic Antagonists; Narcotics; Substance-Related Disorders | 2004 |
Predictors of retention in methadone programs: a signal detection analysis.
Topics: Adult; California; Combined Modality Therapy; Comorbidity; Counseling; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Health Services Research; Heroin Dependence; HIV Infections; Humans; Illicit Drugs; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Patient Dropouts; Patient Satisfaction; Risk-Taking; Socioeconomic Factors; Substance-Related Disorders; Veterans | 2006 |
Differential in vitro inhibition of M3G and M6G formation from morphine by (R)- and (S)-methadone and structurally related opioids.
Topics: Alamethicin; Analgesics, Opioid; Dextropropoxyphene; Humans; Ionophores; Methadone; Methadyl Acetate; Microsomes, Liver; Morphine Derivatives | 2006 |
Effect of opioid substitution therapy on alcohol metabolism.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Female; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders | 2006 |
Different components of opioid-substitution treatment predict outcomes of patients with and without a parent with substance-use problems.
Topics: Adult; Alcoholism; Child; Child of Impaired Parents; Cocaine-Related Disorders; Combined Modality Therapy; Counseling; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Guideline Adherence; Heroin Dependence; Hospitals, Veterans; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Narcotics; Opioid-Related Disorders; Patient Dropouts; Substance Abuse Detection; Treatment Outcome; United States; Veterans | 2007 |
Colocating buprenorphine with methadone maintenance and outpatient chemical dependency services.
Topics: Adult; Ambulatory Care; Buprenorphine; Counseling; Delivery of Health Care, Integrated; Female; Health Services Accessibility; Humans; Male; Methadone; Methadyl Acetate; Middle Aged; Naloxone; Narcotics; New York City; Opioid-Related Disorders; Outcome Assessment, Health Care; Patient Care Team; Patient Dropouts; Social Work; Substance Abuse Detection | 2007 |
In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Methadone; Methadyl Acetate; Pyrrolidines; Stereoisomerism; Swine | 2007 |
QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome | 2007 |
Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: a retrospective analysis.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Methadyl Acetate; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Retrospective Studies; Sex Characteristics; Substance Withdrawal Syndrome | 2008 |
No opiate substitutes for the masses of IDUs.
Topics: Female; Harm Reduction; HIV Infections; Humans; Male; Methadone; Methadyl Acetate; Narcotics; Needle-Exchange Programs; Opioid-Related Disorders; Russia; Substance Abuse, Intravenous; Ukraine | 2010 |
Methadone disposition in oral fluid during pharmacotherapy for opioid-dependence.
Topics: Chromatography, Liquid; Female; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Methadone; Methadyl Acetate; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pyrrolidines; Saliva | 2011 |
Opioid agonist maintenance for probationers: patient-level predictors of treatment retention, drug use, and crime.
Topics: Adult; Analgesics, Opioid; Baltimore; Crime; Female; Heroin Dependence; Humans; Longitudinal Studies; Male; Methadone; Methadyl Acetate; Middle Aged; Opioid-Related Disorders; Patient Compliance; Prisoners; Proportional Hazards Models; Treatment Outcome; Young Adult | 2012 |