methadone and lofexidine

methadone has been researched along with lofexidine in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (24.24)	18.7374
1990's	6 (18.18)	18.2507
2000's	10 (30.30)	29.6817
2010's	9 (27.27)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Agren, H	1
Geyer, G; Resnick, RB; Washton, AM	1
Resnick, RB; Washton, AM	2
Garwood, J; Perzel, JF; Resnick, RB; Washton, AM	1
Annitto, WJ; Extein, I; Gold, MS; Pottash, AC; Sweeney, DR	2
Greenwood, J; Seivewright, NA	1
Bearn, J; Gossop, M; Strang, J	3
Brown, AS; Fleming, PM	1
Carnwath, T; Hardman, J	1
Bearn, J; Buntwal, N; Gossop, M; Strang, J	1
Ali, RL; Farrell, M; Gowing, LR; White, JM	1
Allen, S; Farrell, M; Gupta, J; Howells, C; Marsden, J; Stillwell, G	1
Bearn, J; Best, D; Beswick, T; Gossop, M; Rees, S; Strang, J	1
Epstein, DH; Preston, KL; Schmittner, J; Schroeder, JR	1
Bearn, J; de Wet, CJ; Glasper, A; Gossop, M; Reed, LJ	1
Cubells, JF; Tang, YL; Zhao, C; Zhao, D	1
Bearn, J; Best, D; Beswick, T; Gossop, M; McCambridge, J; Rees, S; Strang, J	1
Bleiberg, J; Epstein, DH; Krantz, MJ; Preston, KL; Schmittner, J; Schroeder, JR	1
Eid, NC; Epstein, DH; Krantz, MJ; Preston, KL; Schmittner, J; Schroeder, JR	1
Meader, N	1
Bramness, J; Gossop, M; Lobmaier, P; Waal, H	1
Day, E; Strang, J	1
Law, F; Melichar, J; O'Shea, J; Praveen, KT	1
Ali, R; Farrell, M; Gowing, L; White, JM	1
Ali, R; Gowing, L; Mbewe, D; White, JM	1
Coulton, S; Diaper, AM; Law, FD; Melichar, JK; Myles, JS; Nutt, DJ	1

Reviews

9 review(s) available for methadone and lofexidine

Article	Year
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327 Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome	1986
What is important in drug misuse treatment? Lancet (London, England), 1996, Feb-10, Volume: 347, Issue:8998 Topics: Buprenorphine; Clonidine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Substance-Related Disorders; United Kingdom	1996
Lofexidine for opiate detoxification: review of recent randomised and open controlled trials. The American journal on addictions, 1999,Fall, Volume: 8, Issue:4 Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome	1999
Alpha2-adrenergic agonists in opioid withdrawal. Addiction (Abingdon, England), 2002, Volume: 97, Issue:1 Topics: Adrenergic alpha-Agonists; Clonidine; Confidence Intervals; Controlled Clinical Trials as Topic; Humans; Methadone; Narcotics; Odds Ratio; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome	2002
Opiate addiction in China: current situation and treatments. Addiction (Abingdon, England), 2006, Volume: 101, Issue:5 Topics: Buprenorphine; China; Clonidine; Drugs, Chinese Herbal; HIV Infections; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Abuse, Intravenous; Substance Withdrawal Syndrome; Sympatholytics	2006
A comparison of methadone, buprenorphine and alpha(2) adrenergic agonists for opioid detoxification: a mixed treatment comparison meta-analysis. Drug and alcohol dependence, 2010, Apr-01, Volume: 108, Issue:1-2 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Buprenorphine; Clonidine; Data Interpretation, Statistical; Humans; Methadone; Narcotic Antagonists; Narcotics; Odds Ratio; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Treatment Outcome	2010
The pharmacological treatment of opioid addiction--a clinical perspective. European journal of clinical pharmacology, 2010, Volume: 66, Issue:6 Topics: Adrenergic Agonists; Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Social Support; Substance Withdrawal Syndrome	2010
Alpha₂-adrenergic agonists for the management of opioid withdrawal. The Cochrane database of systematic reviews, 2016, May-03, Issue:5 Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Clonidine; Controlled Clinical Trials as Topic; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	2016
Buprenorphine for managing opioid withdrawal. The Cochrane database of systematic reviews, 2017, 02-21, Volume: 2 Topics: Acute Disease; Buprenorphine; Clonidine; Female; Humans; Male; Methadone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome	2017

Trials

12 trial(s) available for methadone and lofexidine

Article	Year
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory. Acta psychiatrica Scandinavica. Supplementum, 1986, Volume: 327 Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Clonidine; Dextropropoxyphene; Drug Therapy, Combination; Heroin Dependence; Humans; Locus Coeruleus; Methadone; Morphine; Naltrexone; Narcotics; Norepinephrine; Rats; Substance Withdrawal Syndrome	1986
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:9 Topics: Adult; Ambulatory Care; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Humans; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Substance Withdrawal Syndrome	1983
Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal. Drug and alcohol dependence, 1996, Dec-02, Volume: 43, Issue:1-2 Topics: Adolescent; Adult; Blood Pressure; Clonidine; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Neurologic Examination; Substance Abuse Detection; Substance Withdrawal Syndrome	1996
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification. Drug and alcohol dependence, 1998, May-01, Volume: 50, Issue:3 Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypotension; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Severity of Illness Index; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Treatment Outcome	1998
Randomised double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal. Drug and alcohol dependence, 1998, May-01, Volume: 50, Issue:3 Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Care; Blood Pressure; Chi-Square Distribution; Clonidine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Severity of Illness Index; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome	1998
Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification. Drug and alcohol dependence, 2000, May-01, Volume: 59, Issue:2 Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Neurologic Examination; Opioid-Related Disorders; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome	2000
Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone. Drug and alcohol dependence, 2002, Jul-01, Volume: 67, Issue:2 Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Prisons; Substance Withdrawal Syndrome	2002
In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone. Drug and alcohol dependence, 2007, Apr-17, Volume: 88, Issue:1 Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Clonidine; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Methadone; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Treatment Outcome	2007
Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study. Pharmacotherapy, 2007, Volume: 27, Issue:8 Topics: Adolescent; Adult; Blood Pressure; Clonidine; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Narcotic Antagonists; Narcotics; Pilot Projects; Prospective Studies; Substance Withdrawal Syndrome	2007
Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study. Pharmacotherapy, 2009, Volume: 29, Issue:5 Topics: Adult; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Pilot Projects; Risk Factors; Sex Characteristics	2009
Outpatient versus inpatient opioid detoxification: a randomized controlled trial. Journal of substance abuse treatment, 2011, Volume: 40, Issue:1 Topics: Analgesics, Opioid; Clonidine; Female; Heroin; Heroin Dependence; Humans; Inpatients; Male; Methadone; Narcotics; Opioid-Related Disorders; Outcome Assessment, Health Care; Outpatients; Substance Withdrawal Syndrome; Substance-Related Disorders; Treatment Outcome	2011
Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals. Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:8 Topics: Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Clonidine; Craving; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult	2017

Other Studies

13 other study(ies) available for methadone and lofexidine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Recent advances in opiate detoxification: clonidine and lofexidine. NIDA research monograph, 1983, Volume: 43 Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1983
Opiate detoxification using lofexidine. NIDA research monograph, 1982, Volume: 41 Topics: Antihypertensive Agents; Clonidine; Humans; Male; Methadone; Opioid-Related Disorders	1982
Lofexidine blocks acute opiate withdrawal. NIDA research monograph, 1982, Volume: 41 Topics: Antihypertensive Agents; Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome	1982
Lofexidine in abrupt methadone withdrawal. Psychopharmacology bulletin, 1982, Volume: 18, Issue:4 Topics: Clonidine; Humans; Male; Methadone; Substance Withdrawal Syndrome	1982
Opiate detoxification with lofexidine. Drug and alcohol dependence, 1981, Volume: 8, Issue:4 Topics: Clonidine; Humans; Methadone; Norepinephrine; Substance Withdrawal Syndrome; Time Factors	1981
A naturalistic study of home detoxification from opiates using lofexidine. Journal of psychopharmacology (Oxford, England), 1998, Volume: 12, Issue:1 Topics: Adult; Clonidine; Female; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Treatment Outcome	1998
Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments. Addiction biology, 2003, Volume: 8, Issue:1 Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Sleep Wake Disorders; Substance Withdrawal Syndrome; Time Factors	2003
QT interval increased after single dose of lofexidine. BMJ (Clinical research ed.), 2004, Nov-06, Volume: 329, Issue:7474 Topics: Adult; Clonidine; Female; Humans; Long QT Syndrome; Methadone; Narcotic Antagonists	2004
Induction of patients with moderately severe methadone dependence onto buprenorphine. Addiction biology, 2005, Volume: 10, Issue:2 Topics: Adult; Buprenorphine; Clonidine; Drug Administration Schedule; Female; Humans; Male; Methadone; Narcotic Antagonists; Opioid-Related Disorders; Severity of Illness Index; Surveys and Questionnaires	2005
Opioid dependence. American family physician, 2012, Sep-15, Volume: 86, Issue:6 Topics: Buprenorphine; Clonidine; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Prognosis; Risk Factors; Substance Withdrawal Syndrome; Time Factors	2012
Management of opioid withdrawal symptoms. The Medical letter on drugs and therapeutics, 2018, 08-27, Volume: 60, Issue:1554 Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	2018
Expanded table: Some drugs for management of opioid withdrawal symptoms. The Medical letter on drugs and therapeutics, 2018, 08-27, Volume: 60, Issue:1554 Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome	2018