methadone and ketoconazole

methadone has been researched along with ketoconazole in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (42.86)	29.6817
2010's	8 (57.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Nagashima, R; Nishikawa, T; Tobita, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Glen, RC; Lowe, R; Mitchell, JB	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Feingold, A; Gonsai, K; Kosten, TR; Oliveto, A; Sevarino, KA	1
DeVane, CL; Wang, JS	1
Dilmaghanian, S; Filler, SG; Gal, J; Gerber, JG; Sanchez, A	1
Aman, AM; Kukanich, B; Lascelles, BD; Mealey, KL; Papich, MG	1
Haining, RL; Yu, AM	1
Elliot, DJ; Janchawee, B; Miners, JO; Raungrut, P; Somogyi, AA; Uchaipichat, V	1
Kukanich, B; Kukanich, KS; Rodriguez, JR	1
KuKanich, B; KuKanich, K	1
Shen, L; Tu, F; Wang, J; Wang, R; Xia, G; Xu, J; Ye, C; Yi, Y; Yu, C; Zheng, Z	1

Reviews

1 review(s) available for methadone and ketoconazole

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

2 trial(s) available for methadone and ketoconazole

Article	Year
Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug and alcohol dependence, 2002, Apr-01, Volume: 66, Issue:2 Topics: Analysis of Variance; Antifungal Agents; Chi-Square Distribution; Cocaine-Related Disorders; Double-Blind Method; Humans; Ketoconazole; Methadone; Narcotics; Opioid-Related Disorders; Proportional Hazards Models	2002
The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs. Veterinary anaesthesia and analgesia, 2011, Volume: 38, Issue:3 Topics: Administration, Oral; Analgesics, Opioid; Animals; Area Under Curve; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Therapy, Combination; Female; Fluoxetine; Ketoconazole; Male; Methadone; Prospective Studies; Trimethoprim	2011

Article

Year

Ketoconazole increases cocaine and opioid use in methadone maintained patients.

Drug and alcohol dependence, 2002, Apr-01, Volume: 66, Issue:2

Topics: Analysis of Variance; Antifungal Agents; Chi-Square Distribution; Cocaine-Related Disorders; Double-Blind Method; Humans; Ketoconazole; Methadone; Narcotics; Opioid-Related Disorders; Proportional Hazards Models

2002

The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs.

Veterinary anaesthesia and analgesia, 2011, Volume: 38, Issue:3

Topics: Administration, Oral; Analgesics, Opioid; Animals; Area Under Curve; Chloramphenicol; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Therapy, Combination; Female; Fluoxetine; Ketoconazole; Male; Methadone; Prospective Studies; Trimethoprim

2011

Other Studies

11 other study(ies) available for methadone and ketoconazole

Article	Year
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:6 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Methadone; Microsomes, Liver; Paroxetine; Pyrrolidines; Recombinant Proteins; Stereoisomerism; Trimethoprim	2003
Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates. Chirality, 2004, Volume: 16, Issue:2 Topics: Antifungal Agents; Candida; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Inhibitory Concentration 50; Ketoconazole; Methadone; Molecular Structure; Stereoisomerism; Testosterone	2004
The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs. Journal of veterinary pharmacology and therapeutics, 2005, Volume: 28, Issue:5 Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dogs; Enzyme Inhibitors; Female; Gastric Acid; Injections, Intravenous; Ketoconazole; Male; Methadone; Omeprazole; Proton Pump Inhibitors	2005
Expression, purification, and characterization of mouse CYP2d22. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Amino Acid Sequence; Animals; Baculoviridae; Cell Line; Cloning, Molecular; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dealkylation; Dextromethorphan; Enzyme Inhibitors; Fluoxetine; Insecta; Ketoconazole; Kinetics; Methadone; Mice; Molecular Sequence Data; Molecular Weight; Quinidine; Sequence Homology, Amino Acid; Substrate Specificity	2006
In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:2 Topics: Analgesics, Opioid; Animals; Cattle; Codeine; Dextropropoxyphene; Drug Interactions; Fluconazole; Glucuronosyltransferase; Humans; In Vitro Techniques; Ketoconazole; Methadone; Microsomes, Liver; Models, Biological; Serum Albumin, Bovine	2010
Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs. Veterinary anaesthesia and analgesia, 2015, Volume: 42, Issue:6 Topics: Administration, Oral; Analgesics, Opioid; Animals; Chloramphenicol; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Interactions; Female; Fluoxetine; Ketoconazole; Male; Medetomidine; Methadone; Trimethoprim	2015
Inhibitory effect of isavuconazole, ketoconazole, and voriconazole on the pharmacokinetics of methadone in vivo and in vitro. Drug testing and analysis, 2019, Volume: 11, Issue:4 Topics: Analgesics, Opioid; Animals; Antifungal Agents; Ketoconazole; Male; Methadone; Nitriles; Pyridines; Rats, Sprague-Dawley; Triazoles; Voriconazole	2019