methadone has been researched along with fluconazole in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Chang, TK; Ensom, MH; Kiang, TK | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Collins, JM; Jamis-Dow, C; Klecker, RW; Trapnell, CB | 1 |
| Brown, LS; Cobb, MN; Desai, J; Rainey, PM; Zannikos, PN | 1 |
| Pereira, J; Tarumi, Y; Watanabe, S | 1 |
| Antonini-Canterin, F; Brieda, M; Cassin, M; Dametto, E; Di Gennaro, G; Hrovatin, E; Lestuzzi, C; Meneguzzo, N; Nicolosi, GL; Piazza, R; Viel, E; Zardo, F | 1 |
| Elliot, DJ; Janchawee, B; Miners, JO; Raungrut, P; Somogyi, AA; Uchaipichat, V | 1 |
| KuKanich, B; KuKanich, K; Locuson, CW; Rankin, D | 1 |
| Joo, H; KuKanich, B; KuKanich, K; Locuson, CW; Rankin, DC | 1 |
| Berke, K; Cho, P; Comroe, A; Crauer, B; Fitzgerald, AH; Gonzalez, SE; Jensen, G; Klocke, EE; Komp, M; KuKanich, B; KuKanich, K; Mason, D; Orchard, R; Rankin, DC; Upchurch, DA | 1 |
| Cho, P; Fitzgerald, AH; Komp, MS; KuKanich, B; KuKanich, K; Locuson, CW; Rankin, DC | 1 |
| Acton, EK; Bilker, WB; Brensinger, CM; Dawwas, GK; Hennessy, S; Leonard, CE; Li, L; Miano, TA; Neuman, M; Nguyen, TPP; Soprano, SE; Wang, L; Woody, G; Yu, E | 1 |
| Berke, KA; Bieberly, ZD; Comroe, AJ; Fitzgerald, AH; Jugan, MC; Klocke, EE; Klutzke, JB; KuKanich, B; KuKanich, KS; Mason, DE; Orchard, RJ; Upchurch, DA; Woodruff, K | 1 |
2 review(s) available for methadone and fluconazole
| Article | Year |
|---|---|
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
4 trial(s) available for methadone and fluconazole
| Article | Year |
|---|---|
The effect of fluconazole on the clinical pharmacokinetics of methadone.
Topics: Adult; Antifungal Agents; Area Under Curve; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Female; Fluconazole; Humans; Male; Methadone; Narcotics; Time Factors | 1998 |
The effect of fluconazole on oral methadone in dogs.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Antifungal Agents; Cross-Over Studies; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluconazole; Male; Methadone | 2019 |
Pharmacokinetics and pharmacodynamics of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Fluconazole; Methadone; Naltrexone; Opioid-Related Disorders | 2020 |
Long-acting injectable methadone (methadone-fluconazole) provides safe and effective postoperative analgesia in a randomized clinical trial for dogs undergoing soft tissue surgery.
Topics: Analgesia; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fluconazole; Hysterectomy; Methadone; Ovariectomy; Pain, Postoperative | 2022 |
14 other study(ies) available for methadone and fluconazole
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Glucuronidation of 3'-azido-3'-deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid.
Topics: Anti-HIV Agents; Anticonvulsants; Antifungal Agents; Atovaquone; Drug Interactions; Fluconazole; Glucuronates; Humans; In Vitro Techniques; Methadone; Microsomes, Liver; Naphthoquinones; Narcotics; Valproic Acid; Zidovudine | 1998 |
Methadone and fluconazole: respiratory depression by drug interaction.
Topics: Analgesics, Opioid; Antifungal Agents; Drug Interactions; Fluconazole; Humans; Male; Methadone; Middle Aged; Respiratory Insufficiency | 2002 |
[Long QT and torsade de pointes in a patient with acquired human immunodeficiency virus infection in multitherapy with drugs affecting cytochrome P450].
Topics: Acquired Immunodeficiency Syndrome; Analgesics, Opioid; Antifungal Agents; Antiretroviral Therapy, Highly Active; Cytochrome P-450 Enzyme System; Drug Combinations; Electrocardiography; Fluconazole; Humans; Long QT Syndrome; Male; Methadone; Opioid-Related Disorders; Torsades de Pointes; Treatment Outcome | 2004 |
In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans.
Topics: Analgesics, Opioid; Animals; Cattle; Codeine; Dextropropoxyphene; Drug Interactions; Fluconazole; Glucuronosyltransferase; Humans; In Vitro Techniques; Ketoconazole; Methadone; Microsomes, Liver; Models, Biological; Serum Albumin, Bovine | 2010 |
Perioperative analgesia associated with oral administration of a novel methadone-fluconazole-naltrexone formulation in dogs undergoing routine ovariohysterectomy.
Topics: Administration, Oral; Analgesia; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fluconazole; Humans; Hysterectomy; Methadone; Naltrexone; Ovariectomy; Pain, Postoperative | 2020 |
Multiple-dose pharmacokinetics and opioid effects of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Fluconazole; Humans; Methadone; Naltrexone; Opioid-Related Disorders | 2021 |
Identifying Clinically Relevant Drug-Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection.
Topics: Baclofen; Bayes Theorem; Benzodiazepines; Buprenorphine; Clonidine; Drug Interactions; Fluconazole; Humans; Methadone; Methocarbamol; Opiate Overdose; Opiate Substitution Treatment; Opioid-Related Disorders; Quetiapine Fumarate; Simvastatin | 2022 |