methadone has been researched along with enkephalin, leucine in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (61.54) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Segal, DS | 1 |
| Browne, RG; Derrington, DC; Segal, DS | 1 |
| Terenius, L | 1 |
| Berkowitz, DS; Burt, SK; Loew, GH | 1 |
| Way, EL | 1 |
| Downs, DA; Wiley, JN | 1 |
| Moody, SG; Peck, AW; Posner, J; Rutter, D; Telekes, A | 1 |
| LoPresti, D; Porreca, F; Ward, SJ | 1 |
| Blancquaert, JP; Lefebvre, RA; Willems, JL | 1 |
| Olley, JE; Tiong, GK | 1 |
| Corti, V; Fantozzi, R; Ledda, F; Mantelli, L | 1 |
| Cabib, S; Mele, A; Puglisi-Allegra, S | 1 |
| Browne, RG; Segal, DS | 1 |
| Neil, A | 1 |
| Clemens, JA; Shaar, CJ | 1 |
| Huidobro, F; Huidobro-Toro, JP | 1 |
| Krystal, JH; Redmond, DE | 1 |
| Nencini, P; Paroli, E | 1 |
| Domenici, MR; Longo, R; Sagratella, S | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F | 1 |
| Blake, AD; Bot, G; Freeman, JC; Reisine, T | 1 |
| Blake, AD; Bot, G; Li, S; Reisine, T | 1 |
| Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB | 1 |
| Kreek, MJ; Levran, O; Nielsen, DA; Proudnikov, D; Yuferov, V | 1 |
| Belkaï, E; Courtin, C; Crété, D; Marie-Claire, C; Noble, F | 1 |
| Saadat, M; Saify, K | 1 |
3 review(s) available for methadone and enkephalin, leucine
| Article | Year |
|---|---|
Structure-activity studies of narcotic agonists and antagonists from quantum chemical calculations.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Enkephalins; In Vitro Techniques; Methadone; Models, Molecular; Molecular Conformation; Nalorphine; Narcotic Antagonists; Narcotics; Oxymorphone; Piperidines; Quantum Theory; Receptors, Opioid; Structure-Activity Relationship; Thermodynamics | 1978 |
Multiple mechanisms of withdrawal from opioid drugs.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Benzodiazepines; Calcium; Calmodulin; Clonidine; Conditioning, Psychological; Cyclic GMP; Dopamine; Drug Tolerance; Enkephalins; Fear; gamma-Aminobutyric Acid; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Norepinephrine; Protein Conformation; Receptors, Opioid; Serotonin; Substance Withdrawal Syndrome | 1984 |
Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catechol O-Methyltransferase; Cocaine-Related Disorders; Enkephalins; Epigenesis, Genetic; Genetic Markers; Genetic Variation; Genome-Wide Association Study; Haplotypes; Humans; Methadone; Opioid-Related Disorders; Pharmacogenetics; Protein Precursors; Receptor, Melanocortin, Type 2; Receptor, Serotonin, 5-HT1B; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tryptophan Hydroxylase | 2010 |
1 trial(s) available for methadone and enkephalin, leucine
| Article | Year |
|---|---|
Analgesic, central, cardiovascular and endocrine effects of the enkephalin analogue Tyr-D.Arg-Gly-Phe(4NO2)-Pro-NH2 (443C81) in healthy volunteers.
Topics: Adult; Amino Acid Sequence; Analgesics; Analgesics, Opioid; Blood Pressure; Central Nervous System; Double-Blind Method; Endocrine Glands; Enkephalins; Heart Rate; Hemodynamics; Hormones; Humans; Male; Methadone; Molecular Sequence Data; Pain; Pain Measurement; Pupil; Random Allocation; Salivation | 1990 |
22 other study(ies) available for methadone and enkephalin, leucine
| Article | Year |
|---|---|
Some considerations regarding the characterization and interpretation of neuropeptide-induced behavioral changes.
Topics: Animals; Behavior, Animal; Benzimidazoles; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Haloperidol; Humans; Injections, Intravenous; Injections, Intraventricular; Methadone; Mice; Morphine; Motor Activity; Naloxone; Peptides; Rats; Time Factors | 1978 |
Comparison of opiate- and opioid-peptide-induced immobility.
Topics: Amygdala; Animals; Benzimidazoles; Brain; Caudate Nucleus; Endorphins; Enkephalins; Globus Pallidus; Injections; Injections, Intraventricular; Injections, Subcutaneous; Male; Methadone; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1979 |
Opioid peptides and opiates differ in receptor selectivity.
Topics: Animals; Brain; Dextrorphan; Endorphins; Enkephalins; Isomerism; Levorphanol; Methadone; Morphine; Naloxone; Naltrexone; Rats; Receptors, Opioid | 1977 |
Review and overview of four decades of opiate research.
Topics: Animals; Drug Tolerance; Endorphins; Enkephalins; History, 20th Century; Humans; Ions; Lipid Metabolism; Methadone; Morphine Derivatives; Nalorphine; Narcotics; Receptors, Opioid; Substance-Related Disorders | 1979 |
Naloxone-precipitated jumping in mice pretreated with acute injections of opioids.
Topics: Animals; Behavior, Animal; Cyclazocine; Dose-Response Relationship, Drug; Enkephalins; Heroin; Male; Methadone; Methadyl Acetate; Mice; Morphine; Naloxone; Narcotics; Pentazocine | 1979 |
Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Methadone; Mice; Morphine; Morphine Derivatives; Naltrexone; Receptors, Opioid; Vas Deferens | 1990 |
Antiaversive properties of opioids in the conditioned taste aversion test in the rat.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Fentanyl; Male; Methadone; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Taste | 1987 |
Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain.
Topics: Animals; Brain; Buprenorphine; Dose-Response Relationship, Drug; Enkephalins; Female; Methadone; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1988 |
Inhibition of the cardiac response to sympathetic nerve stimulation by opioid peptides and its potentiation by morphine and methadone.
Topics: Animals; beta-Endorphin; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Guinea Pigs; Heart; In Vitro Techniques; Male; Methadone; Morphine; Myocardial Contraction; Norepinephrine; Sympathetic Nervous System | 1984 |
Involvement of endogenous opioid systems in social behavior of individually-housed mice.
Topics: Aggression; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Methadone; Mice; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Receptors, Opioid; Social Behavior; Social Isolation | 1984 |
Behavioral activating effects of opiates and opioid peptides.
Topics: Animals; Benzimidazoles; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Exploratory Behavior; Male; Methadone; Mice; Morphine; Motor Activity; Naloxone; Narcotics; Rats | 1980 |
Affinities of some common opioid analgesics towards four binding sites in mouse brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding Sites; Brain; Codeine; Cyclazocine; Dextropropoxyphene; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Methionine; Ethylketocyclazocine; In Vitro Techniques; Membranes; Methadone; Mice; Models, Biological; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1984 |
The effects of opiate agonists on growth hormone and prolactin release in rats.
Topics: Animals; Apomorphine; Enkephalins; Growth Hormone; Male; Methadone; Morphine; Naloxone; Naltrexone; Parasympathomimetics; Prolactin; Rats; Receptors, Cholinergic; Receptors, Dopamine; Receptors, Opioid; Secretory Rate | 1980 |
Central effects of morphine, levorphanol, (-)-methadone and the opioid-like peptides beta-endorphin and D-alanine2- methionine enkephalinamide on urine volume outflow and electrolytes.
Topics: Animals; beta-Endorphin; Brain; Diuresis; Electrolytes; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Levorphanol; Male; Methadone; Morphine; Naloxone; Narcotics; Rats; Vasopressins | 1981 |
The lipolytic activity of met-enkephalin, leu-enkephalin, morphine, methadone and naloxone in human adipose tissue.
Topics: Adipose Tissue; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Fatty Acids, Nonesterified; Female; Humans; Lipolysis; Male; Methadone; Naloxone | 1981 |
Selective opposite modulation of dentate granule cells excitability by mu and kappa opioids in rat hippocampal slices.
Topics: Animals; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Methadone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 1996 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone; Morphine; Naloxone; Phenylalanine; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Substance Withdrawal Syndrome | 1996 |
Differential opioid agonist regulation of the mouse mu opioid receptor.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1997 |
Opioid regulation of the mouse delta-opioid receptor expressed in human embryonic kidney 293 cells.
Topics: Adenylyl Cyclases; Animals; Antibodies, Monoclonal; Cell Line; Colforsin; Cyclic AMP; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; GTP-Binding Proteins; Humans; Methadone; Mice; Morphine; Point Mutation; Radioligand Assay; Receptors, Opioid, delta; Signal Transduction; Structure-Activity Relationship | 1997 |
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors | 1998 |
Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Enkephalins; Male; Methadone; Morphine; Neostriatum; Nociceptin Receptor; Nucleus Accumbens; Pro-Opiomelanocortin; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Thalamus; Transcription, Genetic | 2013 |
Expression levels of OPRM1 and PDYN in human SH-SY5Y cells treated with morphine and methadone.
Topics: Analgesics, Opioid; Cell Line; Dose-Response Relationship, Drug; Enkephalins; Humans; Methadone; Morphine; Protein Precursors; Receptors, Opioid, mu; RNA, Messenger | 2016 |