Compounds > methadone

methadone and enkephalin, ala(2)-mephe(4)-gly(5)-

methadone has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's7 (63.64)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Domenici, MR; Longo, R; Sagratella, S1
Blake, AD; Bot, G; Freeman, JC; Reisine, T1
Cheung, P; Li, JG; Liu-Chen, LY; Raffa, RB; Tzeng, TB1
Borgland, SL; Christie, MJ; Connor, M; Furness, JB; Osborne, PB1
Bailey, CP; Couch, D; Griffiths, K; Henderson, G; Johnson, E; Kelly, E1
Brockmöller, J; Geisslinger, G; Lötsch, J; Oertel, BG; Schmidt, H; Skarke, C; Wieting, J1
Allen, JW; Horais, KA; Tozier, NA; Yaksh, TL1
He, L; Whistler, JL1
D'Addario, C; Hansen, M; Johansson, B; Langel, U; Ming, Y; Rigler, R; Schulz, R; Terenius, L; Vukojević, V1
Arttamangkul, S; Low, MJ; Pintar, J; Quillinan, N; von Zastrow, M; Williams, JT1
Ingram, SL; Lamberts, JT; Li, MH; Neubig, RR; Smith, CE; Traynor, JR1

Other Studies

11 other study(ies) available for methadone and enkephalin, ala(2)-mephe(4)-gly(5)-

ArticleYear
Selective opposite modulation of dentate granule cells excitability by mu and kappa opioids in rat hippocampal slices.
    Neuroscience letters, 1996, Feb-16, Volume: 205, Issue:1

    Topics: Animals; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Methadone; Narcotics; Pyrrolidines; Rats; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors

1996
Differential opioid agonist regulation of the mouse mu opioid receptor.
    The Journal of biological chemistry, 1997, Jan-10, Volume: 272, Issue:2

    Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Buprenorphine; Colforsin; Cyclic AMP; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Levorphanol; Methadone; Mice; Morphine; Pertussis Toxin; Receptors, Opioid, mu; Virulence Factors, Bordetella

1997
Apparent thermodynamic parameters of ligand binding to the cloned rat mu-opioid receptor.
    European journal of pharmacology, 1998, Aug-07, Volume: 354, Issue:2-3

    Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Ligands; Methadone; Morphine; Naltrexone; Narcotic Antagonists; Pentazocine; Peptide Fragments; Peptides; Radioligand Assay; Rats; Receptors, Opioid, mu; Somatostatin; Sufentanil; Thermodynamics; Time Factors

1998
Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.
    The Journal of biological chemistry, 2003, May-23, Volume: 278, Issue:21

    Topics: Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Methadone; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Pentazocine; Pituitary Neoplasms; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured

2003
Mu-opioid receptor desensitization in mature rat neurons: lack of interaction between DAMGO and morphine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Nov-19, Volume: 23, Issue:33

    Topics: Analgesics, Opioid; Animals; Cells, Cultured; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guinea Pigs; Humans; In Vitro Techniques; Kidney; Locus Coeruleus; Male; Methadone; Morphine; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Opioid, mu; Transfection

2003
Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.
    Clinical pharmacology and therapeutics, 2006, Volume: 79, Issue:1

    Topics: Adult; Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Central Nervous System; Cytochrome P-450 Enzyme System; DNA; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Genotype; Humans; Male; Methadone; Middle Aged; Models, Statistical; Narcotics; Phenotype; Polymorphism, Genetic; Pupil; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; Stereoisomerism; Tissue Distribution

2006
Opiate pharmacology of intrathecal granulomas.
    Anesthesiology, 2006, Volume: 105, Issue:3

    Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Granuloma; Injections, Spinal; Male; Maximum Tolerated Dose; Methadone; Morphine; Spinal Cord

2006
The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain.
    Pharmacology, 2007, Volume: 79, Issue:4

    Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Methadone; Morphine; Morphine Dependence; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu

2007
Mu-opioid receptor activation in live cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:10

    Topics: Animals; Cell Membrane; Endocytosis; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Green Fluorescent Proteins; Humans; Membrane Lipids; Methadone; Models, Biological; Morphine; PC12 Cells; Rats; Receptors, Opioid, mu

2008
Differential activation and trafficking of micro-opioid receptors in brain slices.
    Molecular pharmacology, 2008, Volume: 74, Issue:4

    Topics: Analgesics, Opioid; Animals; Brain; Chelating Agents; Egtazic Acid; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fluorescent Antibody Technique, Direct; Locus Coeruleus; Methadone; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neurons; Oxycodone; Oxymorphone; Protein Transport; Radioligand Assay; Receptors, Opioid, mu; Recombinant Fusion Proteins; Time Factors

2008
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Mar-06, Volume: 33, Issue:10

    Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord

2013