methadone has been researched along with dextromethorphan in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.00) | 18.7374 |
| 1990's | 6 (21.43) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bastos, ML; Jukofsky, D; Mulé, SJ | 1 |
| Pert, CB; Snyder, SH | 1 |
| Catlin, D; Cleeland, R; Grunberg, E | 1 |
| Horng, JS; Wong, DT | 1 |
| Terenius, L | 1 |
| Chait, LD; Griffiths, RR | 1 |
| Carter, FE; Chau, TT; Harris, LS | 1 |
| Bochner, F; Kerry, NL; Mikus, G; Somogyi, AA | 1 |
| Brödemann, R; Krug, M; Matthies, R; Wagner, M | 1 |
| Bardou, LG; Berthou, F; Dréano, Y; Iribarne, C; Ménez, JF | 1 |
| Elliott, KJ; Gorman, AL; Inturrisi, CE | 1 |
| Bisaga, A; Gianelli, P; Popik, P | 1 |
| Mikedi, K; Statheropoulos, M; Tzamtzis, N | 1 |
| Bulka, A; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Bead, V; Caruso, FS; Childress, AR; Cornish, JW; Ehrman, RN; Esmonde, CA; Herman, BH; Martz, K; O'Brien, CP; Poole, S; Robbins, SJ | 1 |
| Gonsai, K; Kosten, TR; Oliveto, A; Poling, J | 1 |
| Lotrich, FE; Pollock, BG; Rosen, J | 1 |
| Haining, RL; Yu, AM | 1 |
| Compton, PA; Ling, W; Torrington, MA | 1 |
| Iqbal, MZ; Lagundoye, O; Lennard, MS; Rostami-Hodjegan, A; Seivewright, N; Shiran, MR; Tucker, GT | 1 |
| Chang, YH; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Lee, IH; Lee, SY; Lu, RB; Tao, PL; Yang, YK; Yeh, TL | 1 |
| Barbera, N; Busardò, FP; Indorato, F; Romano, G | 1 |
| Ihenetu, K; Na, S; Rosano, TG; Swift, TA; Wood, M | 1 |
| Chang, YH; Chen, KC; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Huang, SY; Lee, IH; Lee, SY; Lu, RB; Tzeng, NS; Wang, LJ; Wang, TY; Yang, YK | 1 |
| Chiang, YC; Ho, IK; Hsu, KY; Hung, TW; Liao, CW; Lo, WJ; Tao, PL; Ye, LC | 1 |
| Akhtar, S; Desai, A; Goldwater, R; Han, D; Howieson, C; Kowalski, D; Lademacher, C; Pearlman, H; Rammelsberg, D; Townsend, R; Yamazaki, T | 1 |
1 review(s) available for methadone and dextromethorphan
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
8 trial(s) available for methadone and dextromethorphan
| Article | Year |
|---|---|
Effects of methadone on human cigarette smoking and subjective ratings.
Topics: Dextromethorphan; Dose-Response Relationship, Drug; Humans; Male; Methadone; Narcotics; Pupil; Smoking; Substance-Related Disorders | 1984 |
Opiate withdrawal with dextromethorphan.
Topics: Adult; Aged; Dextromethorphan; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Patient Satisfaction; Substance Withdrawal Syndrome; Treatment Outcome | 1997 |
A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone-maintained male inpatients.
Topics: Adult; Analysis of Variance; Dextromethorphan; Double-Blind Method; Humans; Inpatients; Male; Methadone; Middle Aged; Opioid-Related Disorders | 2002 |
Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure.
Topics: Adult; Analysis of Variance; Blood Pressure; Dextromethorphan; Discrimination Learning; Dose-Response Relationship, Drug; Female; Humans; Isradipine; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders | 2004 |
Lack of effect of chronic dextromethorphan on experimental pain tolerance in methadone-maintained patients.
Topics: Adolescent; Adult; Analgesics, Opioid; Dextromethorphan; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Humans; Hyperalgesia; Male; Methadone; Middle Aged; Pain Threshold; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Young Adult | 2008 |
Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment.
Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Analgesics, Opioid; Central Nervous System Stimulants; Dextromethorphan; Double-Blind Method; Female; Heroin Dependence; Humans; Inflammation; Interleukin-8; Male; Methadone; Middle Aged; Morphine; Opiate Substitution Treatment; Secondary Prevention; Substance Abuse Detection; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
A placebo-controlled trial of dextromethorphan as an adjunct in opioid-dependent patients undergoing methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Dextromethorphan; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Humans; Interleukin-6; Interleukin-8; Male; Methadone; Middle Aged; Morphine; Opioid-Related Disorders; Retention, Psychology; Time Factors; Transforming Growth Factor beta1; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects.
Topics: Adult; Area Under Curve; Bupropion; Caffeine; Carbamates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Methadone; Middle Aged; Nitriles; Piperidines; Pyridines; Triazoles; Young Adult | 2017 |
19 other study(ies) available for methadone and dextromethorphan
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Evaluation of immunoassay methods for detection, in urine, of drugs subject to abuse.
Topics: Amphetamine; Apomorphine; Barbiturates; Chromatography, Thin Layer; Cocaine; Codeine; Cross Reactions; Cyclazocine; Dextromethorphan; Dextropropoxyphene; Evaluation Studies as Topic; Hemagglutination Inhibition Tests; Heroin; Humans; Hydromorphone; Levorphanol; Methadone; Methods; Microchemistry; Morphine; Nalorphine; Radioimmunoassay; Spectrometry, Fluorescence; Substance-Related Disorders; Time Factors; Tritium | 1974 |
Opiate receptor: demonstration in nervous tissue.
Topics: Analgesics; Animals; Atropine; Binding, Competitive; Brain; Carbachol; Codeine; Colchicine; Dextromethorphan; Dextropropoxyphene; Guinea Pigs; Histamine; Intestinal Mucosa; Levallorphan; Methadone; Mice; Morphine; Nalorphine; Naloxone; Phenazocine; Phenobarbital; Rats; Receptors, Drug; Serotonin; Tritium | 1973 |
A sensitive, rapid radioimmunoassay for morphine and immunologically related substances in urine and serum.
Topics: Animals; Antibody Specificity; Chromatography, Thin Layer; Cross Reactions; Dextromethorphan; Female; Goats; Heroin Dependence; Humans; Immune Sera; Male; Methadone; Methods; Morphine; Radioimmunoassay; Tritium | 1973 |
Stereospecific interaction of opiate narcotics in binding of 3H-dihydromorphine to membranes of rat brain.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Membrane; Corpus Striatum; Dextromethorphan; Kinetics; Levorphanol; Male; Methadone; Morphine; Naloxone; Protein Binding; Rats; Receptors, Drug; Synaptosomes; Tritium | 1973 |
Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain.
Topics: Acetylcholine; Animals; Binding, Competitive; Brain Stem; Cerebral Cortex; Chloromercuribenzoates; Codeine; Dextromethorphan; Ethylmaleimide; Female; Heroin; In Vitro Techniques; Levorphanol; Methadone; Morphinans; Morphine; Nalorphine; Naloxone; Physostigmine; Rats; Receptors, Drug; Structure-Activity Relationship; Subcellular Fractions; Synaptic Membranes; Tritium | 1973 |
Antitussive effect of the optical isomers of mu, kappa and sigma opiate agonists/antagonists in the cat.
Topics: Animals; Antitussive Agents; Blood Pressure; Cats; Codeine; Cyclazocine; Dextromethorphan; Female; Heart Rate; Male; Methadone; Morphine; Narcotics; Phenazocine; Stereoisomerism | 1983 |
The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.
Topics: Autoantibodies; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextropropoxyphene; Dextrorphan; Humans; In Vitro Techniques; Methadone; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Perhexiline; Phenotype; Quinidine | 1994 |
Non-opioid antitussives and methadone differentially influence hippocampal long-term potentiation in freely moving rats.
Topics: Animals; Codeine; Dextromethorphan; Drug Synergism; Electric Stimulation; Evoked Potentials; Hippocampus; Male; Methadone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
Interaction of methadone with substrates of human hepatic cytochrome P450 3A4.
Topics: Binding, Competitive; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Diazepam; Fluvoxamine; Humans; Methadone; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Rifampin | 1997 |
The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord.
Topics: Animals; Binding Sites; Binding, Competitive; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isomerism; Male; Methadone; Pipecolic Acids; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Membranes | 1997 |
Short column gas chromatography-mass spectrometry and principal component analysis for the identification of coeluted substances in doping control analysis.
Topics: Cocaine; Dextromethorphan; Dextropropoxyphene; Factor Analysis, Statistical; Gas Chromatography-Mass Spectrometry; Methadone; Narcotics; Software; Substance Abuse Detection; Time Factors | 1998 |
Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan.
Topics: Analgesics, Opioid; Animals; Catalepsy; Central Nervous System; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Methadone; Morphine; Neurons; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 2002 |
Dextromethorphan-induced delirium and possible methadone interaction.
Topics: Aged; Analgesics, Opioid; Antitussive Agents; Cough; Delirium; Depressive Disorder; Dextromethorphan; Drug Interactions; Female; Humans; Methadone; Pain; Selective Serotonin Reuptake Inhibitors; Sertraline | 2005 |
Expression, purification, and characterization of mouse CYP2d22.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Cell Line; Cloning, Molecular; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dealkylation; Dextromethorphan; Enzyme Inhibitors; Fluoxetine; Insecta; Ketoconazole; Kinetics; Methadone; Mice; Molecular Sequence Data; Molecular Weight; Quinidine; Sequence Homology, Amino Acid; Substrate Specificity | 2006 |
Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Dextrorphan; Female; Humans; Isomerism; Male; Methadone; Midazolam; Middle Aged; Narcotics; Opioid-Related Disorders; Saliva; Young Adult | 2009 |
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body | 2013 |
Multi-drug and metabolite quantification in postmortem blood by liquid chromatography-high-resolution mass spectrometry: comparison with nominal mass technology.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Chromatography, Liquid; Citalopram; Cocaine; Codeine; Dextromethorphan; Diphenhydramine; Evaluation Studies as Topic; Forensic Pathology; Humans; Hydrocodone; Hydromorphone; Meperidine; Methadone; Morphine; Oxycodone; Oxymorphone; Pyrrolidines; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry | 2014 |
Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring.
Topics: Animals; Antitussive Agents; Dextromethorphan; Female; Male; Methadone; Morphine Dependence; Narcotics; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2015 |