methadone and clozapine

methadone has been researched along with clozapine in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19904 (17.39)18.7374
1990's1 (4.35)18.2507
2000's9 (39.13)29.6817
2010's8 (34.78)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Nagashima, R; Nishikawa, T; Tobita, M1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Glen, RC; Lowe, R; Mitchell, JB1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Carlson, KR; Eibergen, RD2
Nightingale, SL1
Algeri, S; Consolo, S; Ladinsky, H; Ponzio, F; Samanin, R1
Kandel, M; Klein, H; Unglaub, W; Wodarz, N; Zenner, D1
Gibert-Rahola, J; Mico, JA; Rojas-Corrales, MO1
Bomsien, S; Skopp, G1
Ansermot, N; Bochud, M; Crettol, S; Eap, CB; Jaquenoud Sirot, E; Oneda, B1
Flanagan, RJ; Handley, S; Patel, MX1
Masiran, R; Mohamad Isa, MF; Pang, NTP; Suarn Singh, V1
Andrade, G; Câmara-Pestana, L; Simões do Couto, F1

Reviews

3 review(s) available for methadone and clozapine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Antipsychotic-related fatal poisoning, England and Wales, 1993-2013: impact of the withdrawal of thioridazine.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:6

    Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Drug Recalls; England; Heroin; Humans; Methadone; Morphine; Olanzapine; Poisoning; Quetiapine Fumarate; Thioridazine; Wales

2016
[Recommendations about the Use of Psychotropic Medications during the COVID-19 Pandemic].
    Acta medica portuguesa, 2020, Oct-01, Volume: 33, Issue:10

    Topics: Antiviral Agents; Benzodiazepines; Betacoronavirus; Bipolar Disorder; Body Temperature Regulation; Buprenorphine; Clozapine; Coronavirus Infections; COVID-19; Delayed-Action Preparations; Drug Interactions; Hospitalization; Humans; Lithium Compounds; Mental Disorders; Methadone; Narcotic Antagonists; Pandemics; Pneumonia, Viral; Psychotropic Drugs; SARS-CoV-2; Schizophrenia; Smoking Cessation Agents; Valproic Acid

2020

Trials

1 trial(s) available for methadone and clozapine

ArticleYear
The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.
    Pharmacogenetics and genomics, 2009, Volume: 19, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Clozapine; Cohort Studies; Cytochrome P-450 CYP3A; Female; Gene Frequency; Genotype; Humans; Male; Methadone; Midazolam; Middle Aged; Pharmacogenetics; Phenotype

2009

Other Studies

19 other study(ies) available for methadone and clozapine

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5

    Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine

2012
MICE models: superior to the HERG model in predicting Torsade de Pointes.
    Scientific reports, 2013, Volume: 3

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes

2013
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2

    Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior

1976
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors

1976
From the Food and Drug Administration.
    JAMA, 1990, Jan-12, Volume: 263, Issue:2

    Topics: Clozapine; Dibenzazepines; Humans; Methadone; Schizophrenia; Tryptophan; United States; United States Food and Drug Administration

1990
Long-term effects of haloperidol, Clozapine, and methadone on rat striatal cholinergic and dopaminergic dynamics.
    Advances in biochemical psychopharmacology, 1980, Volume: 24

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Tolerance; Haloperidol; Homovanillic Acid; Male; Methadone; Neurons; Parasympathetic Nervous System; Rats

1980
[Neuroleptic therapy of comorbid narcotic dependent patients in ambulatory methadone maintenance].
    Psychiatrische Praxis, 2003, Volume: 30 Suppl 2

    Topics: Adult; Ambulatory Care; Antipsychotic Agents; Clozapine; Comorbidity; Drug Therapy, Combination; Female; Follow-Up Studies; Heroin Dependence; Hospitals, Psychiatric; Humans; Methadone; Outpatient Clinics, Hospital; Patient Readmission; Schizophrenia; Secondary Prevention; Treatment Outcome

2003
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
    Psychopharmacology, 2007, Volume: 190, Issue:2

    Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Indophenol; Levorphanol; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Stereotyped Behavior; Tics; Tourette Syndrome; Tramadol; Triazoles

2007
An in vitro approach to potential methadone metabolic-inhibition interactions.
    European journal of clinical pharmacology, 2007, Volume: 63, Issue:9

    Topics: Algorithms; Amitriptyline; Analgesics, Opioid; Atomoxetine Hydrochloride; Chromatography, Liquid; Citalopram; Clozapine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Isoenzymes; Kinetics; Methadone; Methylation; N-Methyl-3,4-methylenedioxyamphetamine; Oxidoreductases, N-Demethylating; Propylamines; Psychotropic Drugs; Pyridines; Pyrrolidines; Tandem Mass Spectrometry; Zolpidem

2007
Directly observed therapy for clozapine with concomitant methadone prescription: a method for improving adherence and outcome.
    BMJ case reports, 2017, Jul-27, Volume: 2017

    Topics: Adult; Antipsychotic Agents; Clozapine; Directly Observed Therapy; Drug Administration Schedule; Heroin Dependence; Humans; Male; Medication Adherence; Methadone; Opiate Substitution Treatment; Schizophrenia; Social Environment; Treatment Outcome

2017