methadone has been researched along with 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in 113 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.88) | 18.7374 |
| 1990's | 11 (9.73) | 18.2507 |
| 2000's | 53 (46.90) | 29.6817 |
| 2010's | 43 (38.05) | 24.3611 |
| 2020's | 5 (4.42) | 2.80 |
| Authors | Studies |
|---|---|
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Baugh, LD; Liu, RH; Walia, AS | 1 |
| Abbott, FS; Kang, GI | 1 |
| de Vos, JW; Geerlings, PJ; Ufkes, JG; van den Brink, W; van Wilgenburg, H | 1 |
| Foltz, RL; Gygi, SP; Nagasawa, PR; Rollins, DE; Wilkins, DG | 1 |
| Alburges, ME; Foltz, RL; Huang, W; Moody, DE | 1 |
| Lanz, M; Thormann, W | 1 |
| Cirimele, V; Eser, HP; Kintz, P; Mangin, P; Moeller, M; Tracqui, A | 1 |
| Blaschke, G; Frost, M; Köhler, H | 1 |
| Aymard, N; Chikhi-Chorfi, N; Claude, JR; Galons, H; Laqueille, X; Massicot, F; Pham-Huy, C; Sadeg, N; Warnet, JM | 1 |
| Caslavska, J; Lanz, M; Portmann, R; Siegenthaler, P; Thormann, W | 1 |
| Cooper, GA; Oliver, JS | 1 |
| Chikhi-Chorfi, N; Claude, JR; Galons, H; Lowenstein, W; Manuel, N; Pham-Huy, C; Warnet, JM | 1 |
| Bermejo, AM; Fernández, P; Lucas, AC; Strano-Rossi, S; Tabernero, MJ | 1 |
| Bermejo, A; dos Santos Lucas, AC; Fernández, P; Tabernero, MJ | 1 |
| Boulton, DW; Devane, CL | 1 |
| Bochner, F; Foster, DJ; Somogyi, AA | 1 |
| Bochner, F; Dyer, KR; Foster, DJ; Somogyi, AA; White, JM | 1 |
| Pragst, F; Sporkert, F | 1 |
| Girod, C; Staub, C | 1 |
| Arnaud, P; Boulton, DW; DeVane, CL | 1 |
| Dale, O; Hoffer, C; Kharasch, ED; Sheffels, P | 1 |
| DeVane, CL; Wang, JS | 1 |
| Dawson, M; Doble, P; Kelly, T | 3 |
| Prost, F; Thormann, W | 1 |
| Astley, P; Cottee, H; Fahey, T; Law, F | 1 |
| Davoudzadeh, D; Epstein, DH; Huestis, MA; Preston, KL | 1 |
| Gal, J; Gerber, JG; Rhodes, RJ | 1 |
| DeVane, CL; Donovan, JL; Markowitz, JS; Ruan, Y; Taylor, RM; Wang, JS | 1 |
| Bézie, Y; Billaud, E; Boutouyrie, P; Illier, C; Lillo, A; Prognon, P; Talon, V | 1 |
| Dale, O; Kharasch, ED; Sheffels, P | 1 |
| Kharasch, ED; Sheffels, P; Whittington, D | 1 |
| Kovar, KA; Trkulja, S | 1 |
| Choo, RE; Huestis, MA; Jones, HE; Murphy, CM | 1 |
| Epstein, DH; Medrano, JG; Moolchan, ET; Preston, KL; Rodriguez-Rosas, ME; Wainer, IW | 1 |
| Eichhorst, JC; Etter, ML; Fern, B; George, S; Graybiel, K; Kapur, B; Lehotay, DC; Selby, P; Wildenboer, W | 1 |
| Eichhorst, J; Etter, ML; George, S; Graybiel, K; Lehotay, DC | 1 |
| Bermejo, AM; Fernández, P; Morales, L; Tabernero, MJ; Vázquez, C | 1 |
| Baldwin, D; Cooper, G; Hand, C; Reid, C; Spiehler, V; Wilson, L | 1 |
| Eskola, T; Gunnar, T; Lillsunde, P | 1 |
| Bermejo, AM; López, P; López-Rivadulla, M; Quintela, O | 1 |
| Ahmed, MS; Deshmukh, SV; Hankins, GD; Hieronymus, TL; Nanovskaya, TN; Vargas, R | 1 |
| Marchi, I; Rudaz, S; Selman, M; Veuthey, JL | 1 |
| De Giovanni, N; Fucci, N; Scarlata, S | 1 |
| Bernard, JP; Karinen, R; Khiabani, HZ; Mørland, J; Opdal, MS | 1 |
| Choo, RE; Huestis, MA; Jansson, LM; Scheidweiler, K | 1 |
| Bomsien, S; Skopp, G | 1 |
| Huestis, MA; Jansson, LM; Shakleya, DM | 1 |
| De Giovanni, N; Fucci, N | 2 |
| Brawand, M; Crettol, S; Digon, P; Eap, CB; Golay, KP | 1 |
| Bermejo, AM; Carro, AM; Fernández, P; Lago, M; Lorenzo, RA; Tabernero, MJ | 1 |
| Martins, LF; Wennig, R; Yegles, M | 1 |
| Ahmed, MS; Chang, Y; Greenwald, MK; Lamm, L; Lin, SN; Moody, DE | 1 |
| Cheng, PS; Chien, CS; Lee, CH; Liu, C | 1 |
| De Fazio, S; De Sarro, G; De Siena, A; Gallelli, L; Scordo, MG | 1 |
| Buchard, A; Johansen, SS; Linnet, K; Morling, N; Munkholm, J | 1 |
| Atta-Politou, J; Calokerinos, AC; Maravelias, CP; Nikolaou, PD; Papoutsis, II; Pistos, CM; Spiliopoulou, CA | 1 |
| Johansen, SS; Linnet, K | 1 |
| Danielson, TJ; Mozayani, A; Sanchez, LA | 1 |
| Jacob, S; Jickells, S; Smith, N; Wolff, K | 1 |
| Fang, WB; Lin, SN; Moody, DE; Omiecinski, CJ; Strom, SC; Weyant, DM | 1 |
| Larson, ME; Richards, TM | 1 |
| Cirimele, V; Evans, J; Kintz, P; Villain, M | 1 |
| Bjergum, MW; Langman, LJ; Snozek, CL | 1 |
| Buchard, A; Fregerslev, M; Johansen, SS; Linnet, K; Morling, N; Munkholm, J | 1 |
| Bies, R; Desta, Z; Flockhart, DA; Kamden, LK; Lu, WJ | 1 |
| Choo, RE; Dams, R; Gray, TR; Huestis, MA; Jones, HE | 1 |
| Bourel, B; De Boeck, G; Gosselin, M; Ramirez Fernandez, Mdel M; Samyn, N; Wille, SM | 1 |
| Chen, BS; Chen, CT; Hsu, TI; Huang, MH; Kang, YF; Shen, AY; Wang, TS; Wu, HM; Wu, SN | 1 |
| de Castro, A; Gray, TR; Huestis, MA; Johnson, RE; Jones, HE; Shakleya, DM | 2 |
| Bourel, B; Di Fazio, V; Fernandez, Mdel M; Gosselin, M; Rasmont, P; Samyn, N; Wille, SM | 1 |
| Chuchracki, M; Florek, E; Foryś, D; Kobus, A; Kulza, M; Piekoszewski, W; Seńczuk-Przybyłowska, M | 1 |
| Galceran, MT; Huerta-Fontela, M; Rosa Boleda, M; Ventura, F | 1 |
| Atayee, RS; Best, BM; Leimanis, E; Pesce, AJ | 1 |
| Chen, ACh; Chen, CH; Chen, YT; Fang, CP; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Kuo, HW; Lin, L; Liu, CT; Liu, ML; Liu, SC; Liu, YL; Shih, YH; Su, LW; Tan, HK; Tian, JN; Tsou, HH; Wu, CS; Yang, YH; Yang, YT | 1 |
| Holm, KM; Linnet, K | 2 |
| Becter, ML; Ewald, MB; George, M; Kitzmiller, JP; O'Donell, KA; Salhanick, S | 1 |
| Bogdan, C; Kiss, B; Loghin, F; Pop, A | 1 |
| Barbera, N; Busardò, FP; Indorato, F; Romano, G | 1 |
| Chen, BG; Chen, TJ; Hsu, YC; Huang, MH; Huang, SP; Jones, AW; Lin, DL; Liu, HC; Liu, RH; Wang, YS; Yang, SC | 1 |
| Jantos, R; Skopp, G | 1 |
| Aroni, K; Bacci, M; Carletti, P; De Giovanni, N; Fucci, N; Gambelunghe, C; Lazzarini, A; Rossi, R | 1 |
| Johansen, SS; Linnet, K; Nielsen, MK | 1 |
| Chang, YS; Ho, IK; Hsu, YT; Kuo, HW; Liu, SW; Liu, YL; Tsou, HH; Wang, SC; Wu, SL | 1 |
| Chatterton, C; Cirimele, V; Duez, M; Etter, M; Klinger, N; Turner, K | 1 |
| Goldstein, A; Poklis, A; Poklis, JL; Wolf, CE | 1 |
| Favretto, D; Ferrara, SD; Miolo, G; Monaldi, A; Tucci, M | 1 |
| Ihenetu, K; Na, S; Rosano, TG; Swift, TA; Wood, M | 1 |
| Dementieva, Y; Kraner, JC; Primerano, DA; Rankin, GO; Richards-Waugh, LL | 1 |
| Cela, R; Cores, M; González-Mariño, I; Quintana, JB; Rodríguez, I | 1 |
| Bouquié, R; Dailly, E; Grall-Bronnec, M; Jolliet, P; Mostefa Daho, AB; Renaud, C | 1 |
| Anderson, JL; Carlquist, JF; Fang, WB; Huntinghouse, JA; Johnson, EG; Knight, S; Moody, DE; Rollo, JS; Webster, LR | 1 |
| Gaulier, JM; Kintz, P; Mathiaux, F; Villéger, P | 1 |
| Barceló, D; Bleda, MJ; López de Alda, M; Mastroianni, N | 1 |
| Bruno, R; Hall, W; Lai, FY; Mueller, JF; O'Brien, J; Prichard, J; Thai, PK; van Dyken, E | 1 |
| Della Vedova, CB; Guinan, TM; Kobus, H; Neldner, D; Stockham, P; Voelcker, NH | 1 |
| ElSohly, MA; Godfrey, M; Gul, SW; Gul, W; Stamper, B | 1 |
| Chen, SH; Chiang, YC; Ho, IK; Ho, WJ; Huang, CL; Lane, HY; Ma, WL; Wang, RY; Yang, HT | 1 |
| Ameline, A; Eibel, A; Farrugia, A; Kintz, P; Raul, JS | 1 |
| Brockbals, L; Ebert, LC; Gascho, D; Kraemer, T; Staeheli, SN; Steuer, AE | 1 |
| Benzon, B; Ključević, N; Ključević, Ž; Sutlović, D; Veršić Bratinčević, M | 1 |
| Araújo, ARTS; Barroso, M; Gallardo, E; Prata, M; Restolho, J; Ribeiro, A; Rosado, T; Vaz, C | 1 |
| Braun, C; Gittel, C; Larenza Menzies, MP; Sandbaumhüter, FA; Theurillat, R; Thormann, W | 1 |
| Evrard, CA; Haas, DM; Haneline, LS; Jones, DR; Masters, AR; Metzger, IF; Quinney, SK; Thomas, AE | 1 |
| Calhoun, E; Din, A; Ravishankar, DA; Sethi, R | 1 |
| Andresen-Streichert, H; Beike, J; Dahm, P; Feld, K; Kieliba, T; Klee, A; Rothschild, MA | 1 |
| Aruldhas, BW; Gao, H; Heathman, MA; Ly, RC; Masters, AR; Overholser, BR; Packiasabapathy, S; Quinney, SK; Sadhasivam, S | 1 |
| Buratti, E; Cerioni, A; Cingolani, M; Cippitelli, M; Froldi, R; Mietti, G; Scendoni, R | 1 |
6 trial(s) available for methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
| Article | Year |
|---|---|
A single dose of methadone inhibits cytochrome P-4503A activity in healthy volunteers as assessed by the urinary cortisol ratio.
Topics: Analysis of Variance; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Humans; Hydrocortisone; Methadone; Narcotics; Oxidoreductases, N-Demethylating; Pyrrolidines | 2001 |
Disposition of nasal, intravenous, and oral methadone in healthy volunteers.
Topics: Administration, Intranasal; Administration, Oral; Adult; Cross-Over Studies; Female; Humans; Injections, Intravenous; Male; Methadone; Pupil; Pyrrolidines | 2002 |
Bioavailabilities of rectal and oral methadone in healthy subjects.
Topics: Administration, Oral; Administration, Rectal; Adult; Analgesics, Opioid; Biological Availability; Chromatography, High Pressure Liquid; Dark Adaptation; Female; Humans; Male; Methadone; Pupil; Pyrrolidines | 2004 |
An enantiomer-selective liquid chromatography-tandem mass spectrometry method for methadone and EDDP validated for use in human plasma, urine, and liver microsomes.
Topics: Chromatography, Liquid; Female; Humans; Male; Methadone; Microsomes; Placenta; Pyrrolidines; Stereoisomerism; Tandem Mass Spectrometry | 2008 |
Maternal methadone dose, placental methadone concentrations, and neonatal outcomes.
Topics: Analgesics, Opioid; Apgar Score; Birth Weight; Body Size; Cephalometry; Cocaine; Female; Gestational Age; Humans; Infant, Newborn; Maternal Exposure; Meconium; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Placenta; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimesters; Pyrrolidines; Tissue Distribution | 2011 |
Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Meconium; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Placenta; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pyrrolidines; Umbilical Cord | 2011 |
107 other study(ies) available for methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
| Article | Year |
|---|---|
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Simultaneous gas chromatography/mass spectrometry assay of methadone and 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in urine.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methadone; Pyrrolidines; Reference Standards; Reproducibility of Results | 1991 |
Analysis of methadone and metabolites in biological fluids with gas chromatography--mass spectrometry.
Topics: Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Humans; Methadone; Pyrrolidines; Saliva | 1982 |
Pharmacokinetics of methadone and its primary metabolite in 20 opiate addicts.
Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Female; Humans; Male; Methadone; Pyrrolidines; Reproducibility of Results; Substance-Related Disorders | 1995 |
Quantitative analysis of methadone and two major metabolites in hair by positive chemical ionization ion trap mass spectrometry.
Topics: Animals; Calibration; Deuterium; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Hair; Heroin; Humans; Isotope Labeling; Male; Methadone; Narcotics; Pyrrolidines; Rats; Reference Standards; Sodium Hydroxide; Substance-Related Disorders | 1996 |
Determination of methadone and its N-demethylation metabolites in biological specimens by GC-PICI-MS.
Topics: Ammonia; Centrifugation; Gas Chromatography-Mass Spectrometry; Humans; Methadone; Methane; Methanol; Microsomes, Liver; Narcotics; Pyrrolidines; Reference Standards; Reproducibility of Results | 1996 |
Characterization of the stereoselective metabolism of methadone and its primary metabolite via cyclodextrin capillary electrophoretic determination of their urinary enantiomers.
Topics: Cyclodextrins; Electrophoresis, Capillary; Humans; Methadone; Pyrrolidines; Stereoisomerism | 1996 |
Enantioselective separation of methadone and its main metabolite in human hair by liquid chromatography/ion spray-mass spectrometry.
Topics: Chromatography, Liquid; Hair; Humans; Methadone; Orosomucoid; Pyrrolidines; Spectrometry, Mass, Secondary Ion; Stereoisomerism | 1997 |
Enantioselective determination of methadone and its main metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in serum, urine and hair by capillary electrophoresis.
Topics: Electrophoresis, Capillary; Hair; Humans; Illicit Drugs; Methadone; Molecular Conformation; Pyrrolidines | 1997 |
Enantioselective high-performance liquid chromatography determination of methadone enantiomers and its major metabolite in human biological fluids using a new derivatized cyclodextrin-bonded phase.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Cyclodextrins; Humans; Methadone; Opioid-Related Disorders; Pyrrolidines; Reproducibility of Results; Stereoisomerism | 1997 |
Screening for urinary methadone by capillary electrophoretic immunoassays and confirmation by capillary electrophoresis-mass spectrometry.
Topics: Electrophoresis, Capillary; Humans; Immunoassay; Mass Spectrometry; Methadone; Pyrrolidines | 1998 |
Improved solid-phase extraction of methadone and its two major metabolites from whole blood.
Topics: Chemistry Techniques, Analytical; Deuterium; Gas Chromatography-Mass Spectrometry; Humans; Methadone; Narcotics; Pyrrolidines; Reference Standards | 1998 |
Rapid determination of methadone and its major metabolite in biological fluids by gas-liquid chromatography with thermionic detection for maintenance treatment of opiate addicts.
Topics: Artifacts; Chromatography, Gas; Humans; Methadone; Opioid-Related Disorders; Pyrrolidines; Reproducibility of Results; Saliva | 1998 |
Use of solid-phase microextraction (SPME) for the determination of methadone and EDDP in human hair by GC-MS.
Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Methadone; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection | 2000 |
Solid-phase microextraction in the determination of methadone in human saliva by gas chromatography-mass spectrometry.
Topics: Dimethylpolysiloxanes; Gas Chromatography-Mass Spectrometry; Humans; Methadone; Pyrrolidines; Reproducibility of Results; Saliva; Silicones; Substance Abuse Detection | 2000 |
Development and application of a chiral high performance liquid chromatography assay for pharmacokinetic studies of methadone.
Topics: Administration, Oral; Blood Proteins; Chromatography, High Pressure Liquid; Erythrocytes; Female; Humans; Methadone; Protein Binding; Pyrrolidines; Stereoisomerism | 2000 |
Stereoselective quantification of methadone and its major oxidative metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, in human urine using high-performance liquid chromatography.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Male; Methadone; Middle Aged; Pyrrolidines; Quality Control; Reference Standards; Stereoisomerism | 2000 |
Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.
Topics: Adult; Area Under Curve; Female; Humans; Individuality; Kidney; Linear Models; Male; Methadone; Middle Aged; Narcotics; Orosomucoid; Protein Binding; Pyrrolidines; Stereoisomerism; Substance-Related Disorders; Substrate Specificity | 2000 |
Determination of methadone and its metabolites EDDP and EMDP in human hair by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
Topics: Adsorption; Calibration; Gas Chromatography-Mass Spectrometry; Hair; Humans; Methadone; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity; Temperature | 2000 |
Methadone and EDDP in hair from human subjects following a maintenance program: results of a pilot study.
Topics: Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; Methadone; Narcotics; Pilot Projects; Pyrrolidines; Reproducibility of Results | 2001 |
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Methadone; Microsomes, Liver; Paroxetine; Pyrrolidines; Recombinant Proteins; Stereoisomerism; Trimethoprim | 2003 |
Chiral separation of methadone, 2-ethylidene- 1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP) by capillary electrophoresis using cyclodextrin derivatives.
Topics: Electrophoresis, Capillary; Hydrocarbons; Methadone; Pyrrolidines; Stereoisomerism | 2003 |
Capillary electrophoresis to assess drug metabolism induced in vitro using single CYP450 enzymes (Supersomes): application to the chiral metabolism of mephenytoin and methadone.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Humans; Mephenytoin; Methadone; Microsomes, Liver; Pharmaceutical Preparations; Pyrrolidines; Stereoisomerism | 2003 |
Sudden death in an adult taking methadone: lessons for general practice.
Topics: Adult; Benzodiazepines; Death, Sudden; Drug Overdose; Drug Synergism; Family Practice; Fatal Outcome; Heroin Dependence; Humans; Male; Methadone; Narcotics; Pyrrolidines | 2003 |
Methadone and metabolite urine concentrations in patients maintained on methadone.
Topics: Drug Monitoring; Female; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Male; Methadone; Narcotics; Patient Compliance; Pyrrolidines; Reproducibility of Results | 2003 |
Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Methadone; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Pyrrolidines; Recombinant Proteins; Stereoisomerism | 2004 |
Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice.
Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Male; Methadone; Mice; Mice, Knockout; Narcotics; Pyrrolidines; Tissue Distribution | 2004 |
Compliance with methadone-based substitutive treatment: a proposed model based on immunoassay urinary sample screening.
Topics: Adult; Cross-Sectional Studies; Enzyme Multiplied Immunoassay Technique; Female; Humans; Hydrogen-Ion Concentration; Male; Methadone; Opioid-Related Disorders; Patient Compliance; Pyrrolidines; Sensitivity and Specificity; Sex Factors; Substance Abuse Detection | 2004 |
Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.
Topics: Automation; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Pyrrolidines; Sensitivity and Specificity | 2004 |
Definite peak identification of (R)-and (S)-methadone and (R)- and (S)-EDDP using established HPLC and CE methods.
Topics: Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Indicators and Reagents; Methadone; Pyrrolidines; Stereoisomerism | 2004 |
Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography-mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Hair; Humans; Mass Spectrometry; Methadone; Pyrrolidines; Stereoisomerism | 2005 |
Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, 2-ethyl-5-methyl-3,3-diphenylpyraline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry.
Topics: Atmospheric Pressure; Humans; Mass Spectrometry; Meconium; Methadone; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection.
Topics: Calibration; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Pyrrolidines; Reference Standards; Stereoisomerism | 2005 |
Free and bound enantiomers of methadone and its metabolite, EDDP in methadone maintenance treatment: relationship to dosage?
Topics: Blood Proteins; Dose-Response Relationship, Drug; Humans; Methadone; Molecular Weight; Protein Binding; Pyrrolidines; Stereoisomerism; Substance Withdrawal Syndrome; Substance-Related Disorders | 2005 |
Determination of free and protein-bound methadone and its major metabolite EDDP: enantiomeric separation and quantitation by LC/MS/MS.
Topics: Chromatography, Liquid; Humans; Linear Models; Mass Spectrometry; Methadone; Molecular Structure; Protein Binding; Pyrrolidines; Sensitivity and Specificity; Stereoisomerism | 2005 |
HPLC-DAD determination of opioids, cocaine and their metabolites in plasma.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Cocaine; Codeine; Dopamine Uptake Inhibitors; Female; Forensic Medicine; Humans; Male; Methadone; Morphine; Morphine Derivatives; Pyrrolidines | 2006 |
Comparison of Cozart microplate ELISA and GC-MS detection of methadone and metabolites in human hair.
Topics: Enzyme-Linked Immunosorbent Assay; False Negative Reactions; False Positive Reactions; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Hair; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity; Substance Abuse Detection | 2005 |
Fast gas chromatography/mass spectrometric assay for the validated quantitative determination of methadone and the primary metabolite EDDP in whole blood.
Topics: Gas Chromatography-Mass Spectrometry; Methadone; Molecular Structure; Pyrrolidines; Reference Standards; Time Factors | 2006 |
Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and alprazolam in human plasma by liquid chromatography-electrospray ionization mass spectrometry.
Topics: Alprazolam; Calibration; Chromatography, Liquid; Humans; Methadone; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2006 |
Methadone metabolism by early gestational age placentas.
Topics: Aromatase; Female; Gestational Age; Humans; In Vitro Techniques; Methadone; Microsomes; Narcotics; Placenta; Pregnancy; Pyrrolidines | 2006 |
Evaluation of the influence of protein precipitation prior to on-line SPE-LC-API/MS procedures using multivariate data analysis.
Topics: Alanine; Blood Proteins; Chemical Precipitation; Cholecalciferol; Chromatography, Liquid; Flunitrazepam; Fluoxetine; Mass Spectrometry; Methadone; Multivariate Analysis; Online Systems; Pyrrolidines; Solid Phase Extraction | 2007 |
Sweat testing in addicts under methadone treatment: an Italian experience.
Topics: Aged; Aged, 80 and over; Caffeine; Central Nervous System Stimulants; Cocaine; Cotinine; Dopamine Uptake Inhibitors; Female; Forensic Toxicology; Ganglionic Stimulants; Gas Chromatography-Mass Spectrometry; Hair; Heroin Dependence; Humans; Italy; Male; Methadone; Middle Aged; Narcotics; Nicotine; Pyrrolidines; Sweat | 2008 |
Relationship between methadone and EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) in urine samples from Norwegian prisons.
Topics: Adult; Biomarkers; Drug Monitoring; Humans; Hydrogen-Ion Concentration; Methadone; Middle Aged; Narcotics; Norway; Prisons; Pyrrolidines | 2007 |
A validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric method for the quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-Ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in
Topics: Chromatography, Liquid; Female; Humans; Lactation; Methadone; Milk, Human; Narcotics; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2007 |
An in vitro approach to potential methadone metabolic-inhibition interactions.
Topics: Algorithms; Amitriptyline; Analgesics, Opioid; Atomoxetine Hydrochloride; Chromatography, Liquid; Citalopram; Clozapine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Isoenzymes; Kinetics; Methadone; Methylation; N-Methyl-3,4-methylenedioxyamphetamine; Oxidoreductases, N-Demethylating; Propylamines; Psychotropic Drugs; Pyridines; Pyrrolidines; Tandem Mass Spectrometry; Zolpidem | 2007 |
Validation of a LC-APCI-MS/MS method for quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyraline (EMDP) in infant plasma following protein precipitation.
Topics: Blood Proteins; Chemical Precipitation; Chromatography, Liquid; Humans; Infant; Methadone; Pyrrolidines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2007 |
Methadone in hair and sweat from patients in long-term maintenance therapy.
Topics: Adult; Drug Monitoring; Female; Gas Chromatography-Mass Spectrometry; Hair; Heroin Dependence; Humans; Male; Methadone; Narcotics; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity; Sweat | 2007 |
In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Methadone; Methadyl Acetate; Pyrrolidines; Stereoisomerism; Swine | 2007 |
Microwave-assisted extraction and HPLC-DAD determination of drugs of abuse in human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Cocaine; Codeine; Forensic Medicine; Humans; Illicit Drugs; Methadone; Microwaves; Morphine; Pyrrolidines; Reproducibility of Results; Solvents; Spectrophotometry, Atomic; Substance Abuse Detection | 2007 |
A fast CE method for the achiral separation of methadone and its major metabolites, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline.
Topics: Calibration; Coated Materials, Biocompatible; Dextran Sulfate; Electrophoresis, Capillary; Forensic Toxicology; Hydrogen-Ion Concentration; Methadone; Phosphates; Polyethylenes; Pyrrolidines; Quaternary Ammonium Compounds; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2007 |
Simultaneous enantioselective quantification of methadone and of 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine in oral fluid using capillary electrophoresis.
Topics: Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Methadone; Pyrrolidines; Reproducibility of Results; Saliva; Sensitivity and Specificity; Stereoisomerism | 2008 |
Simultaneous determination of ketamine, tramadol, methadone, and their metabolites in urine by gas chromatography-mass spectrometry.
Topics: Analgesics; Gas Chromatography-Mass Spectrometry; Humans; Ketamine; Methadone; Narcotics; Pyrrolidines; Tramadol | 2008 |
Role of CYP3A5 in abnormal clearance of methadone.
Topics: Adult; Alleles; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Humans; Male; Methadone; Polymorphism, Single Nucleotide; Pyrrolidines; Substance Abuse Detection | 2008 |
Dominance of pre-analytical over analytical variation for measurement of methadone and its main metabolite in postmortem femoral blood.
Topics: Chromatography, Liquid; Femoral Vein; Forensic Toxicology; Humans; Methadone; Models, Statistical; Narcotics; Pyrrolidines; Tandem Mass Spectrometry | 2008 |
Development and validation of an EI-GC-MS method for the determination of methadone and its major metabolites (EDDP and EMDP) in human breast milk.
Topics: Adult; Calibration; Female; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Infant, Newborn; Linear Models; Methadone; Milk, Human; Narcotics; Pyrrolidines; Quality Control; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization | 2008 |
Chiral analysis of methadone and its main metabolite EDDP in postmortem blood by liquid chromatography-mass spectrometry.
Topics: Autopsy; Calibration; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Methadone; Narcotics; Pharmaceutical Preparations; Pyrrolidines; Quality Control; Reproducibility of Results; Stereoisomerism | 2008 |
Methadone and methadone metabolites in postmortem specimens.
Topics: Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Forensic Toxicology; Humans; Liver; Methadone; Narcotics; Pyrrolidines; Tandem Mass Spectrometry | 2008 |
Stability of methadone and its main metabolite in oral fluid.
Topics: Drug Stability; Drug Storage; Gas Chromatography-Mass Spectrometry; Heroin Dependence; Humans; Methadone; Narcotics; Pyrrolidines; Reproducibility of Results; Saliva; Solid Phase Microextraction; Temperature; Time Factors | 2008 |
Drug testing by chemical analysis of fingerprint deposits from methadone-maintained opioid dependent patients using UPLC-MS/MS.
Topics: Chromatography, Liquid; Dermatoglyphics; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pyrrolidines; Substance Abuse Detection; Tandem Mass Spectrometry | 2008 |
Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes.
Topics: Adult; Aged; Analgesics, Opioid; Antibiotics, Antitubercular; Biotransformation; Buprenorphine; Cells, Cultured; Chromatography, Liquid; Dealkylation; Drug Interactions; Female; Glucuronides; Hepatocytes; HIV Protease Inhibitors; Humans; Intestinal Mucosa; Kinetics; Male; Methadone; Microsomes, Liver; Middle Aged; Nelfinavir; Pyrrolidines; Rifampin; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2009 |
Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance.
Topics: Analgesics, Opioid; Chronic Disease; Creatinine; Female; Follow-Up Studies; Humans; Male; Methadone; Monitoring, Physiologic; Pain; Pyrrolidines; Retrospective Studies; Substance-Related Disorders; Wisconsin | 2009 |
Interpretation of hair findings in children after methadone poisoning.
Topics: Child, Preschool; Chromatography, Liquid; Drug Overdose; Forensic Toxicology; Hair; Humans; Infant; Male; Mass Spectrometry; Methadone; Narcotics; Pyrrolidines | 2010 |
Gas chromatography-mass spectrometry method for the determination of methadone and 2-ethylidene-1,5-dimethyl-3, 3-diphenylpyrrolidine (EDDP).
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methadone; Pyrrolidines; Reproducibility of Results; Solid Phase Extraction | 2010 |
Postmortem blood concentrations of R- and S-enantiomers of methadone and EDDP in drug users: influence of co-medication and p-glycoprotein genotype.
Topics: Adult; Analgesics; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepines; Female; Forensic Genetics; Forensic Toxicology; Genotype; Humans; Male; Methadone; Middle Aged; Narcotics; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Postmortem Changes; Pyrrolidines; Stereoisomerism; Substance-Related Disorders | 2010 |
Methadone: a substrate and mechanism-based inhibitor of CYP19 (aromatase).
Topics: Analgesics, Opioid; Androgens; Aromatase; Aromatase Inhibitors; Estradiol; Estrogens; Humans; Kinetics; Methadone; Microsomes; Pyrrolidines; Recombinant Proteins; Testosterone | 2010 |
Methadone disposition in oral fluid during pharmacotherapy for opioid-dependence.
Topics: Chromatography, Liquid; Female; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Methadone; Methadyl Acetate; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Pregnancy; Pyrrolidines; Saliva | 2011 |
Quantification of methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in third instar larvae of Lucilia sericata (Diptera: Calliphoridae) using liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Diptera; Forensic Medicine; Humans; Larva; Methadone; Narcotics; Pyrrolidines; Sensitivity and Specificity; Substance Abuse Detection; Tandem Mass Spectrometry | 2010 |
Inhibitory action of methadone and its metabolites on erg-mediated K+ current in GH₃ pituitary tumor cells.
Topics: Animals; Cell Line, Tumor; Ether-A-Go-Go Potassium Channels; Methadone; Naloxone; Narcotics; Neurons; Pituitary Neoplasms; Prolactin; Pyrrolidines; Rats; Risperidone | 2011 |
Methadone determination in puparia and its effect on the development of Lucilia sericata (Diptera, Calliphoridae).
Topics: Animals; Chromatography, Liquid; Diptera; Female; Forensic Toxicology; Larva; Male; Mass Spectrometry; Methadone; Narcotics; Pupa; Pyrrolidines | 2011 |
[Develop rapid and inexpensive method for the determination of methadone and its major metabolites for monitoring therapy].
Topics: Drug Monitoring; Humans; Methadone; Opioid-Related Disorders; Pyrrolidines; Reproducibility of Results | 2010 |
Evaluation of the presence of drugs of abuse in tap waters.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cocaine; Cotinine; Drinking Water; Environmental Monitoring; Illicit Drugs; Methadone; Nicotine; Pyrrolidines; Spectrometry, Mass, Electrospray Ionization | 2011 |
Evaluating the relationship of methadone concentrations and EDDP formation in chronic pain patients.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Chronic Pain; Humans; Hydrogen-Ion Concentration; Methadone; Pyrrolidines; Reference Values; Tandem Mass Spectrometry | 2012 |
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
Topics: Adult; Amitriptyline; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Heroin Dependence; Humans; Linkage Disequilibrium; Male; Methadone; Middle Aged; Morphine; Polymorphism, Single Nucleotide; Pyrrolidines; Substance Withdrawal Syndrome; Taiwan | 2012 |
Chiral analysis of methadone and its main metabolite, EDDP, in postmortem brain and blood by automated SPE and liquid chromatography-mass spectrometry.
Topics: Autopsy; Brain; Chromatography, Liquid; Humans; Methadone; Orosomucoid; Pyrrolidines; Reproducibility of Results; Solid Phase Extraction; Tandem Mass Spectrometry | 2012 |
Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
Topics: Cytochrome P-450 CYP3A; Drug Overdose; Humans; Infant, Newborn; Intensive Care Units; Male; Methadone; Phenobarbital; Pyrrolidines | 2012 |
A rapid UPLC-MS/MS method for simultaneous determination of flunitrazepam, 7-aminoflunitrazepam, methadone and EDDP in human, rat and rabbit plasma.
Topics: Animals; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Female; Flunitrazepam; Humans; Male; Methadone; Pyrrolidines; Rabbits; Rats; Reproducibility of Results; Tandem Mass Spectrometry; Time Factors; Toxicity Tests | 2012 |
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Citalopram; Codeine; Dextromethorphan; Drug Contamination; Drug Overdose; Drug Users; Female; Forensic Pathology; Forensic Toxicology; Gastrointestinal Contents; Humans; Illicit Drugs; Kidney; Lidocaine; Liver; Lung; Male; Methadone; Morphine; Morphine Derivatives; Narcotics; Pyrrolidines; Selective Serotonin Reuptake Inhibitors; Substance-Related Disorders; Vitreous Body | 2013 |
Methadone concentrations in blood, plasma, and oral fluid determined by isotope-dilution gas chromatography-mass spectrometry.
Topics: Analgesics, Opioid; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Methadone; Pyrrolidines; Saliva | 2013 |
Postmortem blood and tissue concentrations of R- and S-enantiomers of methadone and its metabolite EDDP.
Topics: Adult; Chromatography, Liquid; Female; Forensic Toxicology; Humans; Male; Mass Spectrometry; Methadone; Narcotics; Postmortem Changes; Pyrrolidines; Stereoisomerism; Tissue Distribution; Young Adult | 2013 |
Sweat testing to monitor drug exposure.
Topics: Adult; Cocaine; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Italy; Male; Methadone; Patch Tests; Pyrrolidines; Substance Abuse Detection; Sweat | 2013 |
Evaluation of metabolite/drug ratios in blood and urine as a tool for confirmation of a reduced tolerance in methadone-related deaths in Denmark.
Topics: Adult; Aged; Cause of Death; Denmark; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Pyrrolidines; Stereoisomerism; Young Adult | 2013 |
Hepatitis C virus infection influences the S-methadone metabolite plasma concentration.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cell Line, Transformed; Cytochrome P-450 CYP2B6; Demography; Dose-Response Relationship, Drug; Female; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Humans; Male; Methadone; Multivariate Analysis; Pyrrolidines; Regression Analysis | 2013 |
Interpretation of pharmaceutical drug concentrations in young children's head hair.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child of Impaired Parents; Child, Preschool; Chromatography, Liquid; Female; Forensic Toxicology; Hair; Humans; Infant; Methadone; Narcotics; Nortriptyline; Pyrrolidines; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol | 2014 |
Evaluation of an enzyme immunoassay for the detection of methadone metabolite EDDP [2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine] in urine.
Topics: Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Ions; Mass Spectrometry; Methadone; Pyrrolidines | 2014 |
A study on photodegradation of methadone, EDDP, and other drugs of abuse in hair exposed to controlled UVB radiation.
Topics: Analgesics, Opioid; Cocaine; Hair; Humans; Methadone; Morphine; Morphine Derivatives; Photolysis; Pyrrolidines; Substance Abuse Detection; Ultraviolet Rays | 2014 |
Multi-drug and metabolite quantification in postmortem blood by liquid chromatography-high-resolution mass spectrometry: comparison with nominal mass technology.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Chromatography, Liquid; Citalopram; Cocaine; Codeine; Dextromethorphan; Diphenhydramine; Evaluation Studies as Topic; Forensic Pathology; Humans; Hydrocodone; Hydromorphone; Meperidine; Methadone; Morphine; Oxycodone; Oxymorphone; Pyrrolidines; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry | 2014 |
Fatal methadone toxicity: potential role of CYP3A4 genetic polymorphism.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Child; Child, Preschool; Cohort Studies; Cytochrome P-450 CYP3A; Female; Genotyping Techniques; Humans; Infant; Male; Methadone; Middle Aged; Polymorphism, Single Nucleotide; Pyrrolidines; Young Adult | 2014 |
Distribution of enantiomers of methadone and its main metabolite EDDP in human tissues and blood of postmortem cases.
Topics: Adult; Aged; Body Mass Index; Brain Chemistry; Female; Forensic Toxicology; Humans; Male; Methadone; Middle Aged; Muscle, Skeletal; Narcotics; Postmortem Changes; Pyrrolidines; Young Adult | 2015 |
Transformation of methadone and its main human metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), during water chlorination.
Topics: Analgesics, Opioid; Animals; Chlorine; Chromatography, Liquid; Cyprinidae; Daphnia; Fresh Water; Halogenation; Humans; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Methadone; Molecular Structure; Pyrrolidines; Rivers; Toxicity Tests; Waste Disposal, Fluid; Water; Water Pollutants, Chemical | 2015 |
Chiral on-line solid phase extraction coupled to liquid chromatography-tandem mass spectrometry assay for quantification of (R) and (S) enantiomers of methadone and its main metabolite in plasma.
Topics: Chromatography, Liquid; Humans; Methadone; Narcotics; Pyrrolidines; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry | 2015 |
A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study.
Topics: Adult; Alleles; Arrhythmias, Cardiac; Cytochrome P-450 CYP2C19; Electrocardiography; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methadone; Pharmacogenetics; Pilot Projects; Polymorphism, Single Nucleotide; Pyrrolidines; Time Factors; Young Adult | 2015 |
Testing for Drugs in Exhaled Breath Collected With ExaBreath in a Drug Dependence Population: Comparison With Data Obtained in Urine After Liquid Chromatographic-Tandem Mass Spectrometric Analyses.
Topics: Adult; Breath Tests; Chromatography, Liquid; Female; Humans; Limit of Detection; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Pyrrolidines; Substance Abuse Detection; Substance-Related Disorders; Tandem Mass Spectrometry | 2016 |
Occurrence of drugs of abuse in surface water from four Spanish river basins: Spatial and temporal variations and environmental risk assessment.
Topics: Cocaine; Environmental Monitoring; Ephedrine; Geography; Illicit Drugs; Methadone; N-Methyl-3,4-methylenedioxyamphetamine; Pyrrolidines; Risk Assessment; Rivers; Spain; Spatio-Temporal Analysis; Water; Water Pollutants, Chemical | 2016 |
Refining the excretion factors of methadone and codeine for wastewater analysis - Combining data from pharmacokinetic and wastewater studies.
Topics: Analgesics, Opioid; Codeine; Humans; Methadone; Pyrrolidines; Wastewater; Water Pollutants, Chemical | 2016 |
Porous silicon mass spectrometry as an alternative confirmatory assay for compliance testing of methadone.
Topics: Adolescent; Adult; Chromatography, Liquid; Humans; Mass Spectrometry; Methadone; Middle Aged; Narcotics; Porosity; Pyrrolidines; Reproducibility of Results; Saliva; Silicon; Substance Abuse Detection; Water; Young Adult | 2017 |
LC-MS-MS Method for the Analysis of Miscellaneous Drugs in Wastewater During Football Games III.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Residues; Fentanyl; Football; Humans; Illicit Drugs; Limit of Detection; Meperidine; Methadone; Mississippi; Phencyclidine; Pyrrolidines; Reproducibility of Results; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol; Wastewater | 2016 |
Reduced dosing and liability in methadone maintenance treatment by targeting oestrogen signal for morphine addiction.
Topics: Adult; Animals; Cytochrome P-450 CYP2B6; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Humans; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine Dependence; Opiate Substitution Treatment; Ovariectomy; Polymorphism, Single Nucleotide; Pyrrolidines; Response Elements; Sex Factors; Signal Transduction; Tamoxifen | 2017 |
High risk of misinterpreting hair analysis results for children tested for methadone.
Topics: Child, Preschool; Chromatography, Liquid; Environmental Exposure; Female; Forensic Toxicology; Hair; Humans; Infant; Limit of Detection; Male; Mass Spectrometry; Methadone; Narcotics; Pyrrolidines; Substance Abuse Detection | 2017 |
Time-Dependent Postmortem Redistribution of Opioids in Blood and Alternative Matrices.
Topics: Analgesics, Opioid; Autopsy; Biotransformation; Chromatography, High Pressure Liquid; Fentanyl; Forensic Toxicology; Humans; Image-Guided Biopsy; Methadone; Opioid-Related Disorders; Postmortem Changes; Predictive Value of Tests; Pyrrolidines; Reproducibility of Results; Substance Abuse Detection; Tandem Mass Spectrometry; Tissue Distribution; Tomography, X-Ray Computed | 2018 |
Liver damage indices as a tool for modifying methadone maintenance treatment: a cross-sectional study.
Topics: Adult; Analgesics, Opioid; Aspartate Aminotransferases; Cross-Sectional Studies; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Opioid-Related Disorders; Platelet Count; Pyrrolidines | 2018 |
Determination of methadone and EDDP in oral fluid using the dried saliva spots sampling approach and gas chromatography-tandem mass spectrometry.
Topics: Analgesics, Opioid; Drug Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Limit of Detection; Methadone; Pyrrolidines; Saliva; Tandem Mass Spectrometry | 2019 |
Enantioselective capillary electrophoresis for pharmacokinetic analysis of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine in equines anesthetized with ketamine and isoflurane.
Topics: Animals; Drug Interactions; Electrophoresis, Capillary; Horses; Isoflurane; Ketamine; Methadone; Pyrrolidines; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2019 |
Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Anticonvulsants; Dried Blood Spot Testing; Female; Humans; Infant, Newborn; Labor, Obstetric; Methadone; Morphine; Neonatal Abstinence Syndrome; Phenobarbital; Pregnancy; Pyrrolidines | 2021 |
Urine toxicology screen negative for Methadone metabolite but positive for Methadone in a patient on Methadone maintenance therapy (MMT).
Topics: Humans; Male; Methadone; Middle Aged; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Pyrrolidines | 2020 |
Evidence for the transfer of methadone and EDDP by sweat to children's hair.
Topics: Adult; Child; Chromatography, Liquid; Female; Gas Chromatography-Mass Spectrometry; Germany; Hair Analysis; Humans; Male; Methadone; Middle Aged; Pyrrolidines; Sweat; Tandem Mass Spectrometry | 2021 |
Pharmacokinetic modeling of R and S-Methadone and their metabolites to study the effects of various covariates in post-operative children.
Topics: Adolescent; Analgesics, Opioid; Biological Variation, Individual; Biological Variation, Population; Child; Female; Humans; Intraoperative Care; Male; Methadone; Orthopedic Procedures; Pain Management; Pain, Postoperative; Pharmacogenomic Variants; Postoperative Care; Pyrrolidines; Stereoisomerism | 2021 |
Detection of Three Opioids (Morphine, Codeine and Methadone) and Their Metabolites (6-Monoacetylmorphine and 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) in Larvae of
Topics: Analgesics, Opioid; Animals; Chromatography, High Pressure Liquid; Codeine; Diptera; Humans; Larva; Methadone; Morphine; Morphine Derivatives | 2023 |