Compounds > metformin

metformin and wortmannin

metformin has been researched along with wortmannin in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Hamann, A; Yuan, L; Ziegler, R1
Holman, GD; Yang, J1
Garabadu, D; Krishnamurthy, S1

Other Studies

5 other study(ies) available for metformin and wortmannin

ArticleYear
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes.
    Chinese medical journal, 2002, Volume: 115, Issue:12

    Topics: Androstadienes; Cells, Cultured; Gene Expression; Hepatocytes; Humans; Hypoglycemic Agents; Metformin; Phosphatidylinositol 3-Kinases; Phosphoenolpyruvate Carboxykinase (GTP); RNA, Messenger; Tumor Cells, Cultured; Wortmannin

2002
Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis.
    Endocrinology, 2006, Volume: 147, Issue:6

    Topics: AMP-Activated Protein Kinases; Androstadienes; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Endocytosis; Exocytosis; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Male; Metformin; Multienzyme Complexes; Myocytes, Cardiac; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Wortmannin

2006
Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABA
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Androstadienes; Animals; Bicuculline; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Receptors, GABA-A; Signal Transduction; Wortmannin

2017