metformin and vitamin b 12

metformin has been researched along with vitamin b 12 in 122 studies

Research

Studies (122)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (9.02)	18.7374
1990's	4 (3.28)	18.2507
2000's	16 (13.11)	29.6817
2010's	55 (45.08)	24.3611
2020's	36 (29.51)	2.80

Authors

Authors	Studies
Caspary, WF; Deuticke, U; Emrich, D; Reimold, W; Willms, B; Zavada, I	1
Bury, J; Carpentier, JL; Lefebvre, P; Luyckx, A	1
Berger, W; Denes, A; Lauffenburger, T	1
Tomkin, GH	1
Asp, NG; Berchtold, P; Dahlqvist, A; Gustafson, A	1
Arbenz, U; Berchtold, P; Bolli, P; Keiser, G	1
Hadden, DR; Montgomery, DA; Tomkin, GH; Weaver, JA	1
Smith, OA; Stowers, JM	1
Adams, JF; Clark, JS; Ireland, JT; Kesson, CM; Watson, WS	1
Ditzel, J; Mourits-Andersen, T	1
Callaghan, TS; Hadden, DR; Tomkin, GH	1
DeFronzo, RA; Goodman, AM	1
Connolly, V; Kesson, CM	1
Bjerve, KS; Carlsen, SM; Følling, I; Grill, V; Refsum, H; Schneede, J	1
Aarsand, AK; Carlsen, SM	1
Bauman, WA; Herbert, V; Jayatilleke, E; Shaw, S; Spungen, AM	1
Buysschaert, M; Dramais, AS; Hermans, MP; Wallemacq, PE	1
Heine, RJ	1
Bets, D; Borger van der Burg, B; Donker, AJ; Kooy, A; Lehert, P; Ogterop, JC; Stehouwer, CD; Wulffelé, MG	1
Chattananon, A; Pongchaidecha, M; Srikusalanukul, V; Tanjariyaporn, S	1
Aslan, E; Bagis, T; Erkanli, S; Haydardedeoglu, B; Kilicdag, EB; Tarim, E; Zeyneloglu, HB	1
van der Meulen, J; Vrijsen, BE	1
Chan, JC; Chow, CC; Cockram, CS; Ma, RC; Tong, PC	1
Bouzid, C; Essais, O; Ibrahim, H; Machghoul, S; Ouertani, H; Ouni, Z; Zidi, B	1
Scarpello, JH; Varughese, GI	1
Carlsen, SM	1
Carlsen, SM; Kjøtrød, S; Romundstad, P; Vanky, E	1
Fitzgerald, MA	1
Ning, G; Zhang, YF	1
Kalathil, D; Musarrat, K; Varughese, GI	1
Buñuel Granados, JM; Esteban Jiménez, O; González Rubio, F; Navarro Pemán, C	1
Hidalgo, SF; Prieto de Paula, JM; Salado Valdivieso, I	1
Toth, C; Wile, DJ	1
Colao, A; Falbo, A; Giallauria, F; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F	1
Malnick, S; Shavit, Y; Stern, F; Tal, S	1
Kassam, R; Leung, S; Mattman, A; Meneilly, G; Nexo, E; Snyder, F	1
Bets, D; de Jager, J; Donker, AJ; Kooy, A; Lehert, P; Stehouwer, CD; van der Kolk, J; Verburg, J; Wulffelé, MG	1
Butler, CC; Vidal-Alaball, J	1
Alfarouk, KO; Bashir, AH	1
Aghamohammadi, V; Aliasgharzadeh, A; Gargari, BP	1
Izquierdo Pradas, L; Mariño Suárez, JE; Milán Vegas, A	1
Garn, JV; Oakley, GP; Qi, YP; Reinstatler, L; Williamson, RS	1
Gidwani, HV; Kumthekar, AA; Kumthekar, AB	1
Calvo Romero, JM; Ramiro Lozano, JM	1
Black, KK; Chung, AH; Pierce, SA	1
Cacciapuoti, F	1
Baghurst, PA; Coat, S; Gatford, KL; Hague, WM; Houda, CM; Lu, ZX; Owens, JA; Rowan, JA; Sikaris, K	1
Foutouhi, SH; Green, R; Greibe, E; Miller, JW; Nexo, E	1
Fang, D; He, X; Huang, Z; Li, Y; Wan, X; Xu, L	1
Bor, MV; Greibe, E; Lauszus, FF; Nexo, E; Trolle, B	1
Ames, D; Boundy, K; Brodaty, H; Bush, AI; Carne, RP; Ellis, KA; Faux, NG; Kotowicz, MA; Mander, AG; Martins, R; Moore, EM; Rowe, C; Szoeke, C; Watters, DA; Woodward, M	1
Aizawa, T; Funase, Y; Ouchi, K; Sato, Y; Yamauchi, K	1
Bilo, HJ; de Groot-Kamphuis, DM; Groenier, KH; Houweling, ST; Kleefstra, N; van Dijk, PR	1
Beulens, JW; Hart, HE; Kooijman-Buiting, AM; Kuijs, R; Rutten, GE	1
Li, J; Li, S; Liu, Q; Quan, H	1
Brouwer-Brolsma, EM; de Groot, LC; de Jonge, R; Dhonukshe-Rutten, RA; Enneman, AW; Ham, AC; Lips, P; Oliai Araghi, S; Sohl, E; Stricker, BH; Swart, KM; Uitterlinden, AG; van der Cammen, TJ; van der Velde, N; van der Zwaluw, NL; van Dijk, SC; van Meurs, JB; van Schoor, NM; van Wijngaarden, JP; Witkamp, RF; Zillikens, MC	1
Ahn, YB; Han, KD; Kim, HS; Ko, SH; Park, YM; Song, KH	1
Ahn, YB; Kang, D; Ko, SH; Lim, TS; Park, YM; Yun, JS	1
Beulens, JW; Biemans, E; Cuellar Renteria, VG; Hart, HE; Kooijman-Buiting, AM; Rutten, GE	1
Hai, F; Nader, ND; Niafar, M; Porhomayon, J	1
Annibale, B; Galli, G; Purchiaroni, F	1
Alibrandi, A; Cucinotta, D; Forte, F; Gambadoro, N; Giandalia, A; Perdichizzi, G; Romeo, EL; Russo, GT; Scarcella, C; Zingale, R	1
Aroda, VR; Bray, GA; Crandall, JP; Edelstein, SL; Goldberg, RB; Knowler, WC; Marcovina, SM; Orchard, TJ; Schade, DS; Temprosa, MG; White, NH	1
Blumberg, G; Carmeli, E; Fogelman, Y; Golan-Cohen, A; Kitai, E; Rapoport, M	1
Cruz, G; Maeshiro, K	1
Barnes, KD; Beatty, SJ; Grever, GM; Lehman, A; Matthews, DE	1
Haeusler, S; Krebs, J; Langdana, F; Parry-Strong, A; Weatherall, M	1
Cashion, WT; Garn, JV; Judd, SE; Kancherla, V; Oakley, GP; Odewole, O; Williamson, RS; Zakai, NA	1
Fleischer, J; Hansen, CS; Jensen, JS; Jørgensen, ME; Ridderstråle, M; Vistisen, D	1
Behera, J; Jeremic, N; Majumder, A; Tyagi, SC	1
Bernstein, V; Brien, W; Chalchal, HI; Chen, BE; Gelmon, KA; Goodwin, PJ; Hershman, DL; Hobday, TJ; Lemieux, J; Liebman, MF; Ligibel, JA; Lohmann, AE; Mayer, IA; Mukherjee, SD; Parulekar, WR; Pritchard, KI; Rastogi, P; Shepherd, LE; Stambolic, V; Thompson, AM; Whelan, TJ	1
Camarero-Shelly, M	1
Elizondo-Plazas, A; González-González, JG; González-Velázquez, C; Montes-Villarreal, J; Rodríguez-Gutiérrez, R; Rodríguez-Velver, KV; Salcido-Montenegro, A	1
Kooy, A; Lehert, P; Out, M; Schalkwijk, CA; Stehouwer, CDA	1
Crandall, JP	1
Hersberger, KE; Metaxas, C; Rudofsky, G; Walter, PN; Zurwerra, C	1
Obeid, R; Ströhle, A	1
Miller, JW	1
Abdelhay, O; Abuhaimed, SN; Al-Asmari, AK; AlHarbi, NG; Alharbi, TJ; Alkhashan, HI; AlRasheed, AN; Bin Rsheed, AM; Mohammed, N; Tourkmani, AM	1
Cai, X; Ji, L; Wu, H; Yang, W	1
Almeida, J; Faria-Costa, G; Leitão, MJ; Mendonça, FM; Pires Da Rosa, G	1
Casey, MC; Cunningham, C; Gallagher, AM; Hoey, L; Hughes, CF; Laird, E; McCann, A; McCarroll, K; McNulty, H; Molloy, AM; O'Kane, M; Porter, KM; Strain, S; Tracey, F; Ward, M	1
Ashor, AW; Khalaf, KM; Khudhair, MS	1
Ahn, CW; Fang, S; Kim, J; Lee, HS; Park, JS	1
Hirota, Y; Ogawa, W; Okada, Y; Sakaguchi, K; Sugawara, K	1
Alvarez, CA; Higbea, AM; Runeberg, HA; Weideman, RA	1
Babaliche, P; Chafekar, ND; Cherulil, SJ	1
Basu, DA; Bhattacharyya, A; Das, SL	1
Al Mahrezi, AM; Al-Gahhafi, M; Al-Hamdi, A; Al-Mamari, A; Al-Roshdi, S; Jaju, S	1
Anadol-Schmitz, E; Bobrov, P; Burkart, V; Kahl, S; Kanti, G; Karusheva, Y; Markgraf, DF; Roden, M; Sarabhai, T; Strassburger, K; Szendroedi, J; Trenkamp, S; Zaharia, OP; Ziegler, D	1
Gautham, K; Gopaldatta, KS; Nishchitha, K; Ramdas, B; Shivaprasad, C	1
Gökışık, MT; Uyar, S	1
Almdal, T; Carstensen, B; Gluud, C; Hansen, CS; Hedetoft, C; Hemmingsen, B; Jørgensen, ME; Krarup, T; Lund, SS; Lundby-Christiansen, L; Madsbad, S; Sneppen, SB; Tarnow, L; Thorsteinsson, B; Wiinberg, N	1
Allen, LL; Kancherla, V; Khakharia, A; Phillips, LS; Rhee, MK; Serra, MC; Vaughan, CP; Wilson, PWF	1
D'Agostino, S; Dolci, M; Favia, G; Limongelli, L	1
El-Sherif, M; Esmael, A; Hashem, MM; Nassar, AK	1
Alam, MS; Chanda, PK; Kamrul-Hasan, AB; Selim, S	1
Berberoglu, M; Dogan, O; Eminoglu, FT; Kontbay, T; Kose, E; Siklar, Z; Taş, Ö; Tumer, L	1
Abuzaid, O; Al-Sheikh, R; Albannawi, M; Alhajjmohammed, D; Alkubaish, Z; Althani, R; Altheeb, L; Altuwajiry, H; Ayoub, H; Khattab, R; Mutwalli, H; Purayidathil, T	1
Bell, DSH	2
Huang, X; Li, BQ; Qiu, ZQ; Xu, N; Zeng, XJ; Zhang, XM	1
Huang, M; Jia, S; Wang, P; Wei, J; Wei, Y	1
Lauren, BC; Pratama, S; Wisnu, W	1
Bilen, A; Bilen, H; Capoglu, I; Ciftel, E; Ciftel, S; Dayanan, R; Kasalı, K; Mercantepe, F; Yanıkoglu, ND	1
Belakhdar, K; Kraroubi, A; Matmour, D; Sakouhi, M	1
Al-Fawaeir, S; Al-Odat, I	1
Qin, S; Wang, Y; Wu, L; Yao, L; Zhu, S	1
Androulakis, J; Bogdanos, DP; Gkouskou, KK; Goulis, DG; Grammatikopoulou, MG; Paschalidou, EG; Roilides, E; Sergentanis, TN; Tsiroukidou, K; Tzimos, C; Vamvakis, A; Vassilakou, T	1
Abu Dahoud, W; Blum, A; Hajouj, T; Horrany, N; Moallem, Y; Zreik, M	1
Chen, H; Hu, Y; Qin, X; Wang, M; Wang, S; Wu, J; Wu, T; Wu, Y; Yang, R; Yu, H	1
Sultana, R; Wee, AKH	1
Facharztmagazine, R	1
Mohammed Ismail, S	1
Dinesh, D; Lee, JS; Palacios, N; Scott, TM; Tucker, KL	1
Bi, Y; Chen, S; Gao, L; Ji, L; Lei, M; Liu, F; Liu, X; Lu, Y; Ran, X; Shen, X; Su, Q; Wang, Y; Zhao, D	1
Chen, M; Huang, W; Kang, Z; Li, Q; Liu, T; Shu, Y; Zhang, W; Zhou, H	1
Ghdhban Al-Ziaydi, A; Hussein Abed, H; Mousa Ali, A	1
Genc, AC; Genc, FT; Kaya, T; Nalbant, A	1

Reviews

10 review(s) available for metformin and vitamin b 12

Article	Year
Mecobalamin. Expert opinion on investigational drugs, 2008, Volume: 17, Issue:6 Topics: Aged; Alprostadil; Animals; Cobamides; Coenzymes; Diabetic Neuropathies; Drug Administration Routes; Drug Therapy, Combination; Female; Folic Acid; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Kidney Failure, Chronic; Male; Metformin; Methionine; Methyltransferases; Peripheral Nervous System Diseases; Randomized Controlled Trials as Topic; Renal Dialysis; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6	2008
Vitamin B12 status in metformin treated patients: systematic review. PloS one, 2014, Volume: 9, Issue:6 Topics: Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic; Treatment Outcome; Vitamin B 12	2014
The role of metformin on vitamin B12 deficiency: a meta-analysis review. Internal and emergency medicine, 2015, Volume: 10, Issue:1 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency	2015
Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy. Journal of cellular biochemistry, 2017, Volume: 118, Issue:8 Topics: Animals; DNA Methylation; Epigenesis, Genetic; Folic Acid; Histones; Homocysteine; Humans; Hyperhomocysteinemia; Metformin; Muscle, Skeletal; Muscular Diseases; Oxidative Stress; RNA Interference; Thiazolidinediones; Vitamin B 12; Vitamin B 6	2017
Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications. Advances in nutrition (Bethesda, Md.), 2018, 07-01, Volume: 9, Issue:4 Topics: Histamine H2 Antagonists; Homocysteine; Humans; Metformin; Methylmalonic Acid; Nutritional Status; Proton Pump Inhibitors; Risk Factors; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency	2018
Associations between metformin use and vitamin B Journal of diabetes, 2019, Volume: 11, Issue:9 Topics: Anemia; Case-Control Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous System Diseases; Prognosis; Vitamin B 12; Vitamin B Complex	2019
Metformin-Induced Vitamin B12 Deficiency among Type 2 Diabetes Mellitus' Patients: A Systematic Review. Current diabetes reviews, 2023, Volume: 19, Issue:4 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2023
Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes. Diabetes, obesity & metabolism, 2022, Volume: 24, Issue:8 Topics: Aged; Calcium; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous System Diseases; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency	2022
Is metformin a possible treatment for diabetic neuropathy? Journal of diabetes, 2022, Volume: 14, Issue:10 Topics: Adenosine Monophosphate; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Hypoglycemic Agents; Metformin; Neuroprotective Agents; Pain; Protein Kinases; Vitamin B 12	2022
The efficacy of vitamin B Diabetes & metabolic syndrome, 2022, Volume: 16, Issue:10 Topics: Diabetes Mellitus, Type 2; Dietary Supplements; Homocysteine; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins	2022

Trials

18 trial(s) available for metformin and vitamin b 12

Article	Year
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fasting; Female; Folic Acid; Glucose Tolerance Test; Glyburide; Glycated Hemoglobin; Humans; Insulin; Lactates; Lactic Acid; Male; Metformin; Middle Aged; Obesity; Treatment Failure; Vitamin B 12	1995
Metformin increases total serum homocysteine levels in non-diabetic male patients with coronary heart disease. Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:6 Topics: Adult; Coronary Disease; Cysteine; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Methylmalonic Acid; Middle Aged; Vitamin B 12	1997
Folate administration reduces circulating homocysteine levels in NIDDM patients on long-term metformin treatment. Journal of internal medicine, 1998, Volume: 244, Issue:2 Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dipeptides; Double-Blind Method; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Prospective Studies; Risk Factors; Time Factors; Treatment Outcome; Vitamin B 12	1998
Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes care, 2000, Volume: 23, Issue:9 Topics: Adult; Calcium Carbonate; Calcium, Dietary; Dietary Supplements; Ethnicity; Humans; Hypoglycemic Agents; Intestinal Absorption; Male; Metformin; Middle Aged; Vitamin B 12	2000
Side effects. Calcium supplements help metformin users absorb vitamin B12. TreatmentUpdate, 2000, Volume: 12, Issue:7 Topics: Calcium; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Intestinal Absorption; Metformin; Vitamin B 12	2000
Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. Journal of internal medicine, 2003, Volume: 254, Issue:5 Topics: Adult; Aged; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Homocystine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Vitamin B 12	2003
Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study. Human reproduction (Oxford, England), 2005, Volume: 20, Issue:4 Topics: Adult; Anovulation; Blood Glucose; Body Weight; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Insulin Resistance; Lipids; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Rosiglitazone; Testosterone; Thiazolidinediones; Vitamin B 12	2005
Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome. Acta obstetricia et gynecologica Scandinavica, 2007, Volume: 86, Issue:2 Topics: Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Metformin; Methylenetetrahydrofolate Reductase (NADPH2); Polycystic Ovary Syndrome; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Prospective Studies; Testosterone; Vitamin B 12	2007
Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients. Clinical biochemistry, 2010, Volume: 43, Issue:9 Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Down-Regulation; Female; Humans; Hypoglycemic Agents; Male; Metformin; Time Factors; Transcobalamins; Vitamin B 12	2010
Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ (Clinical research ed.), 2010, May-20, Volume: 340 Topics: Aged; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Long-Term Care; Male; Metformin; Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency	2010
Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus. Journal of the American College of Nutrition, 2011, Volume: 30, Issue:3 Topics: Administration, Oral; Aged; Antioxidants; Diabetes Mellitus, Type 2; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Folic Acid; Homocysteine; Humans; Male; Malondialdehyde; Metformin; Middle Aged; Oxidative Stress; Vitamin B 12	2011
Vitamin B12 and homocysteine status during pregnancy in the metformin in gestational diabetes trial: responses to maternal metformin compared with insulin treatment. Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:7 Topics: Adult; Biomarkers; Cohort Studies; Diabetes, Gestational; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Insulin; Metformin; Nutritional Status; Postpartum Period; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Pregnancy Trimester, Third; South Australia; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency	2013
Metformin lowers serum cobalamin without changing other markers of cobalamin status: a study on women with polycystic ovary syndrome. Nutrients, 2013, Jul-05, Volume: 5, Issue:7 Topics: Adolescent; Adult; Biomarkers; Body Mass Index; Cohort Studies; Cross-Over Studies; Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Polycystic Ovary Syndrome; Vitamin B 12; Young Adult	2013
Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:4 Topics: Adult; Aged; Anemia; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	2016
Vitamin B12 screening in metformin-treated diabetics in primary care: were elderly patients less likely to be tested? Aging clinical and experimental research, 2017, Volume: 29, Issue:2 Topics: Age Factors; Aged; Comorbidity; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Healthcare Disparities; Humans; Hypoglycemic Agents; Israel; Male; Metformin; Primary Health Care; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency	2017
Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: a randomised trial. The New Zealand medical journal, 2016, Jun-10, Volume: 129, Issue:1436 Topics: Administration, Sublingual; Aged; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Humans; Hypoglycemic Agents; Injections, Intramuscular; Male; Metformin; Middle Aged; New Zealand; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex	2016
Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32. Breast cancer research and treatment, 2017, Volume: 164, Issue:2 Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Female; Homocysteine; Humans; Metformin; Methylmalonic Acid; Middle Aged; Treatment Outcome; Vitamin B 12	2017
Metformin may adversely affect orthostatic blood pressure recovery in patients with type 2 diabetes: substudy from the placebo-controlled Copenhagen Insulin and Metformin Therapy (CIMT) trial. Cardiovascular diabetology, 2020, 09-26, Volume: 19, Issue:1 Topics: Aged; Autonomic Nervous System Diseases; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Hypotension, Orthostatic; Insulin; Male; Metformin; Middle Aged; Peripheral Nervous System Diseases; Risk Factors; Standing Position; Vitamin B 12	2020

Other Studies

94 other study(ies) available for metformin and vitamin b 12

Article	Year
Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides. Diabetologia, 1977, Volume: 13, Issue:3 Topics: Biguanides; Buformin; Carbon Dioxide; Cholic Acids; Diabetes Mellitus; Doxycycline; Feces; Female; Glycocholic Acid; Humans; Male; Metformin; Middle Aged; Phenformin; Vitamin B 12	1977
Vitamin B 12 and folic acid serum levels in diabetics under various therapeutic regimens. Diabete & metabolisme, 1976, Volume: 2, Issue:4 Topics: Diabetes Mellitus; Female; Folic Acid; Humans; Insulin; Iron; L-Lactate Dehydrogenase; Male; Metformin; Sulfonylurea Compounds; Vitamin B 12	1976
The effect of metformin on the absorption of vitamin B 12 . Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1972, Volume: 4, Issue:4 Topics: Adult; Aged; Cobalt Isotopes; Diabetes Mellitus; Female; Humans; Intestinal Absorption; Male; Metformin; Middle Aged; Schilling Test; Time Factors; Vitamin B 12; Whole-Body Counting	1972
Malabsorption of vitamin B12 in diabetic patients treated with phenformin: a comparison with metformin. British medical journal, 1973, Sep-29, Volume: 3, Issue:5882 Topics: Cobalt Isotopes; Diabetes Mellitus; Female; Folic Acid; Hemoglobinometry; Humans; Intestinal Absorption; Male; Metformin; Middle Aged; Phenformin; Schilling Test; Time Factors; Vitamin B 12	1973
Effects of a biguanide (Metformin) on vitamin B 12 and folic acid absorption and intestinal enzyme activities. Scandinavian journal of gastroenterology, 1971, Volume: 6, Issue:8 Topics: Adult; Biopsy; Enzyme Activation; Female; Folic Acid; Galactosidases; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Maltose; Metformin; Middle Aged; Sucrase; Trehalase; Vitamin B 12	1971
[Disturbance of intestinal absorption following metformin therapy (observations on the mode of action of biguanides]. Diabetologia, 1969, Volume: 5, Issue:6 Topics: Body Weight; Diabetes Mellitus; Humans; Intestinal Absorption; Lipids; Metformin; Obesity; Vitamin B 12; Xylose	1969
Vitamin-B12 status of patients on long-term metformin therapy. British medical journal, 1971, Jun-19, Volume: 2, Issue:5763 Topics: Aged; Cobalt Isotopes; Diabetes Mellitus; Dietary Fats; Folic Acid; Hemoglobinometry; Humans; Ileum; Intestinal Absorption; Intrinsic Factor; Lipid Metabolism; Malabsorption Syndromes; Metformin; Middle Aged; Radiography; Vitamin B 12	1971
Vitamin B 12 and metformin. British medical journal, 1971, Jul-24, Volume: 3, Issue:5768 Topics: Acidosis; Diabetes Mellitus; Folic Acid; Humans; Intestinal Absorption; Lactates; Metformin; Phenformin; Vitamin B 12; Vitamin B 12 Deficiency	1971
Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia, 1983, Volume: 24, Issue:1 Topics: Adult; Aged; Biguanides; Diabetes Mellitus; Female; Humans; Intrinsic Factor; Malabsorption Syndromes; Male; Metformin; Middle Aged; Phenformin; Vitamin B 12	1983
[Megaloblastic anemia caused by malabsorption of vitamin B12 during long-term metformin therapy]. Ugeskrift for laeger, 1983, Jan-03, Volume: 145, Issue:1 Topics: Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Diabetes Mellitus; Female; Humans; Malabsorption Syndromes; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	1983
Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment. British medical journal, 1980, May-17, Volume: 280, Issue:6225 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Diabetes Mellitus; Female; Humans; Intestinal Absorption; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	1980
Metformin treatment in NIDDM patients with mild renal impairment. Postgraduate medical journal, 1996, Volume: 72, Issue:848 Topics: Aged; Case-Control Studies; Creatinine; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lactates; Male; Metformin; Middle Aged; Renal Insufficiency; Vitamin B 12	1996
Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance. Diabetes care, 2000, Volume: 23, Issue:12 Topics: Aged; Cohort Studies; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Female; Folic Acid; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Logistic Models; Male; Metabolic Clearance Rate; Metformin; Middle Aged; Vitamin B 12	2000
[Does the vitamin B12 deficiency caused by metformin disappear again after stopping this drug?]. Nederlands tijdschrift voor geneeskunde, 2002, Nov-16, Volume: 146, Issue:46 Topics: Calcium, Dietary; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	2002
Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a cross-sectional study in patients with type 2 diabetes mellitus. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2004, Volume: 87, Issue:7 Topics: Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Vitamin B 12	2004
[Diagnosis of vitamin B12 deficiency revised]. Nederlands tijdschrift voor geneeskunde, 2006, Feb-25, Volume: 150, Issue:8 Topics: Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2006
To: Holstein A, Stumvoll M (2005) Contraindications can damage your health--is metformin a case in point? Diabetologia 48:2454-2459. Diabetologia, 2006, Volume: 49, Issue:5 Topics: Contraindications; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Risk Factors; Vitamin B 12	2006
[Factors influencing homocysteineamia in type 2 diabetic patients]. La Tunisie medicale, 2006, Volume: 84, Issue:5 Topics: Diabetes Mellitus, Type 2; Female; Folic Acid; Glycated Hemoglobin; Homocysteine; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Obesity; Prospective Studies; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency	2006
Metformin and vitamin B12 deficiency: the role of H2 receptor antagonists and proton pump inhibitors. Age and ageing, 2007, Volume: 36, Issue:1 Topics: Aged; Aged, 80 and over; Diabetes Mellitus; Famotidine; Gastritis; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; Metformin; Proton Pump Inhibitors; Vitamin B 12; Vitamin B 12 Deficiency	2007
[Metformin and vitamin B 12 deficiency]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Mar-15, Volume: 127, Issue:6 Topics: Humans; Hypoglycemic Agents; Intestinal Absorption; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2007
Drug-induced vitamin B12 deficiency. The Nurse practitioner, 2007, Volume: 32, Issue:9 Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2007
Metformin, B12 and homocysteine levels: the plausible cause or effect? Journal of the Formosan Medical Association = Taiwan yi zhi, 2008, Volume: 107, Issue:6 Topics: Homocysteine; Humans; Hyperhomocysteinemia; Metformin; Venous Thrombosis; Vitamin B 12; Vitamin B 12 Deficiency	2008
[Vitamin B12 deficiency secondary to metformin therapy]. Medicina clinica, 2010, Jul-17, Volume: 135, Issue:6 Topics: Aged; Anemia; Diabetes Mellitus, Type 2; Drug Synergism; Female; Folic Acid; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Intestinal Absorption; Male; Metformin; Middle Aged; Proton Pump Inhibitors; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency	2010
[Metformin and vitamin B12 deficiency]. Medicina clinica, 2010, Jul-17, Volume: 135, Issue:6 Topics: Aged; Anemia; Female; Folic Acid; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Intestinal Absorption; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2010
Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabetes care, 2010, Volume: 33, Issue:1 Topics: Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Neuropathies; Electrophysiology; Female; Homocysteine; Humans; Hypoglycemic Agents; Immunoassay; Male; Mass Spectrometry; Metformin; Methylmalonic Acid; Middle Aged; Peripheral Nervous System Diseases; Prospective Studies; Vitamin B 12	2010
Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome. Diabetes care, 2010, Volume: 33, Issue:2 Topics: Adult; Body Mass Index; Brachial Artery; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Exercise; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Leisure Activities; Metformin; Placebos; Polycystic Ovary Syndrome; Tunica Intima; Tunica Media; Vasodilation; Vitamin B 12; Waist-Hip Ratio	2010
Association between vitamin B12 levels and mortality in hospitalized older adults. Journal of the American Geriatrics Society, 2010, Volume: 58, Issue:3 Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Hospital Mortality; Humans; Hypoglycemic Agents; Israel; Linear Models; Male; Metformin; Multivariate Analysis; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency	2010
Reduced serum vitamin B-12 in patients taking metformin. BMJ (Clinical research ed.), 2010, May-20, Volume: 340 Topics: Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hypoglycemic Agents; Metformin; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency	2010
Diabetes drug interferes with vitamin B12. Harvard heart letter : from Harvard Medical School, 2010, Volume: 20, Issue:9 Topics: Diabetes Mellitus, Type 2; Folic Acid; Health Knowledge, Attitudes, Practice; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2010
Diabetes mellitus type 2 through oncology lens. Medical hypotheses, 2011, Volume: 76, Issue:5 Topics: Diabetes Complications; Diabetes Mellitus, Type 2; Disease Progression; Female; Humans; Insulin; Ischemia; Male; Metformin; Models, Biological; Models, Theoretical; Polycystic Ovary Syndrome; Prostatic Neoplasms; Vitamin B 12	2011
[Vitamin B12 deficiency in diabetic patients taking metformin]. Medicina clinica, 2012, Apr-28, Volume: 138, Issue:11 Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Retrospective Studies; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex	2012
Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabetes care, 2012, Volume: 35, Issue:2 Topics: Aged; Dietary Supplements; Female; Humans; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	2012
Metformin associated B12 deficiency. The Journal of the Association of Physicians of India, 2012, Volume: 60 Topics: Diabetes Mellitus, Type 2; Humans; Hydroxocobalamin; Hypoglycemic Agents; Malabsorption Syndromes; Male; Metformin; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex	2012
Vitamin B(12) in type 2 diabetic patients treated with metformin. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2012, Volume: 59, Issue:8 Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metformin; Vitamin B 12	2012
Evaluation of vitamin B12 monitoring in a veteran population on long-term, high-dose metformin therapy. The Annals of pharmacotherapy, 2012, Volume: 46, Issue:11 Topics: Anemia; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Monitoring; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Veterans; Vitamin B 12; Vitamin B 12 Deficiency	2012
Lowering homocysteine levels may prevent cardiovascular impairments? Possible therapeutic behaviors. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2012, Volume: 23, Issue:8 Topics: Acetylcysteine; Aspirin; Blood Vessels; Cardiovascular Diseases; Clopidogrel; Diuretics; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Platelet Aggregation Inhibitors; S-Adenosylmethionine; Ticlopidine; Vitamin B 12; Vitamin B 6	2012
Metformin increases liver accumulation of vitamin B12 - an experimental study in rats. Biochimie, 2013, Volume: 95, Issue:5 Topics: Animals; Female; Liver; Metformin; Rats; Rats, Sprague-Dawley; Vitamin B 12	2013
Adverse effect of metformin therapy on serum vitamin B12 and folate: short-term treatment causes disadvantages? Medical hypotheses, 2013, Volume: 81, Issue:2 Topics: Folic Acid; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12	2013
Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes care, 2013, Volume: 36, Issue:10 Topics: Aged; Aged, 80 and over; Calcium; Cognition Disorders; Diabetes Mellitus; Female; Humans; Logistic Models; Male; Metformin; Middle Aged; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency	2013
Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. Endocrine journal, 2013, Volume: 60, Issue:12 Topics: Aged; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Retinopathy; Dietary Supplements; Dose-Response Relationship, Drug; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Japan; Male; Metformin; Middle Aged; Prevalence; Risk Factors; Severity of Illness Index; Stroke; Vitamin B 12; Vitamin B 12 Deficiency	2013
Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin. The Netherlands journal of medicine, 2013, Volume: 71, Issue:7 Topics: Aged; Anemia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Erythrocyte Indices; Female; Hemoglobins; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency	2013
Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta diabetologica, 2015, Volume: 52, Issue:1 Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Time Factors; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency	2015
Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study. Drugs & aging, 2014, Volume: 31, Issue:8 Topics: Aged; Diuretics; Female; Folic Acid; Health Services for the Aged; Homocysteine; Humans; Male; Metformin; Netherlands; Osteoporosis; Population Surveillance; Vitamin B 12; Vitamin B 12 Deficiency	2014
Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. Journal of Korean medical science, 2014, Volume: 29, Issue:7 Topics: Aged; Area Under Curve; Diabetes Mellitus, Type 2; Female; Folic Acid; Humans; Hypoglycemic Agents; Immunoassay; Male; Metformin; Middle Aged; Odds Ratio; Patients; Prevalence; ROC Curve; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency	2014
Higher prevalence of metformin-induced vitamin B12 deficiency in sulfonylurea combination compared with insulin combination in patients with type 2 diabetes: a cross-sectional study. PloS one, 2014, Volume: 9, Issue:10 Topics: Adult; Aged; Diabetes Mellitus, Type 2; Drug Combinations; Female; Folic Acid; Humans; Insulin; Male; Metformin; Middle Aged; Sulfonylurea Compounds; Vitamin B 12; Vitamin B 12 Deficiency	2014
Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin. Acta diabetologica, 2015, Volume: 52, Issue:2 Topics: Adult; Aged; Cognition; Depressive Disorder; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Male; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2015
Metformin plus proton pump inhibitors therapy: the cobalamin deficiency challenge. European review for medical and pharmacological sciences, 2015, Volume: 19, Issue:13 Topics: Aged; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Injections, Intramuscular; Male; Metformin; Proton Pump Inhibitors; Vitamin B 12; Vitamin B 12 Deficiency	2015
Diabetic neuropathy is not associated with homocysteine, folate, vitamin B12 levels, and MTHFR C677T mutation in type 2 diabetic outpatients taking metformin. Journal of endocrinological investigation, 2016, Volume: 39, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Folic Acid; Follow-Up Studies; Genotype; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Outpatients; Prognosis; Vitamin B 12	2016
The importance of ruling out risk factors for vitamin B12 deficiency induced by metformin in older patients Nutricion hospitalaria, 2016, 02-16, Volume: 33, Issue:1 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins	2016
Comparison of 2 Population Health Management Approaches to Increase Vitamin B12 Monitoring in Patients Taking Metformin. The Annals of pharmacotherapy, 2016, Volume: 50, Issue:10 Topics: Appointments and Schedules; Drug Monitoring; Electronic Health Records; Female; Humans; Hypoglycemic Agents; Interprofessional Relations; Male; Metformin; Pharmacists; Physicians; Professional Role; Quality of Health Care; Random Allocation; Vitamin B 12	2016
Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003-2007. PloS one, 2016, Volume: 11, Issue:8 Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins	2016
Vitamin B12 deficiency is associated with cardiovascular autonomic neuropathy in patients with type 2 diabetes. Journal of diabetes and its complications, 2017, Volume: 31, Issue:1 Topics: Antihypertensive Agents; Autonomic Nervous System Diseases; Cardiovascular Diseases; Cohort Studies; Cross-Sectional Studies; Denmark; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Cardiomyopathies; Diabetic Neuropathies; Female; Heart Rate; Humans; Hypertension; Hypoglycemic Agents; Male; Mass Screening; Metformin; Middle Aged; Prevalence; Proton Pump Inhibitors; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency	2017
[Vitamin B Semergen, 2018, Volume: 44, Issue:3 Topics: Adult; Age Factors; Aged; Dementia; Female; Humans; Longitudinal Studies; Male; Mass Screening; Metformin; Middle Aged; Prevalence; Primary Health Care; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Urban Health Services; Vitamin B 12; Vitamin B 12 Deficiency	2018
Metformin Use and Vitamin B12 Deficiency: Untangling the Association. The American journal of the medical sciences, 2017, Volume: 354, Issue:2 Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult	2017
Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial. Journal of diabetes and its complications, 2018, Volume: 32, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Methylmalonic Acid; Middle Aged; Randomized Controlled Trials as Topic; Retrospective Studies; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency	2018
Metformin and vitamin B12-What's missing from this picture? Journal of diabetes and its complications, 2018, Volume: 32, Issue:2 Topics: Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2018
Impact of type 2 Diabetes and Metformin use on Vitamin B12 Associated Biomarkers - an Observational Study. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2018, Volume: 126, Issue:6 Topics: Aged; Biomarkers; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Metformin; Middle Aged; Switzerland; Vitamin B 12; Vitamin B 12 Deficiency	2018
[In process]. Medizinische Monatsschrift fur Pharmazeuten, 2016, Volume: 39, Issue:8 Topics: Diabetes Mellitus, Type 2; Humans; Intestinal Absorption; Metformin; Predictive Value of Tests; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency	2016
The association of metformin use with vitamin B12 deficiency and peripheral neuropathy in Saudi individuals with type 2 diabetes mellitus. PloS one, 2018, Volume: 13, Issue:10 Topics: Diabetes Mellitus, Type 2; Diet; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Peripheral Nervous System Diseases; Prevalence; Retrospective Studies; Risk Factors; Saudi Arabia; Vitamin B 12; Vitamin B 12 Deficiency	2018
Chronic diarrhea: an unusual clinical presentation of vitamin B Internal and emergency medicine, 2019, Volume: 14, Issue:3 Topics: Diabetes Mellitus, Type 1; Diarrhea; Humans; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	2019
Hyperglycemia and Metformin Use Are Associated With B Vitamin Deficiency and Cognitive Dysfunction in Older Adults. The Journal of clinical endocrinology and metabolism, 2019, 10-01, Volume: 104, Issue:10 Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Cohort Studies; Female; Folic Acid; Geriatric Assessment; Humans; Hyperglycemia; Independent Living; Male; Metformin; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6	2019
Vitamin B12 status and peripheral neuropathy in patients with type 2 diabetes mellitus. JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69(Suppl 3), Issue:8 Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Hypoglycemic Agents; Incidence; Iraq; Male; Metformin; Middle Aged; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency	2019
Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. Medicine, 2019, Volume: 98, Issue:46 Topics: Age Factors; Aged; Alcohol Drinking; Anemia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Folic Acid; Homocysteine; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Odds Ratio; Republic of Korea; Time Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins	2019
Relationship between metformin use and vitamin B Journal of diabetes investigation, 2020, Volume: 11, Issue:4 Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Erythrocyte Indices; Female; Hemoglobins; Homocysteine; Humans; Hypoglycemic Agents; Japan; Male; Metformin; Middle Aged; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency	2020
Evaluation of Vitamin B Journal of pharmacy practice, 2021, Volume: 34, Issue:5 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Retrospective Studies; Veterans; Vitamin B 12; Vitamins	2021
Prevalence of Vitamin B12 Defi ciency and Clinical Neuropathy with Metformin Use in Type 2 Diabetes Mellitus Patients. The Journal of the Association of Physicians of India, 2020, Volume: 68, Issue:1 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency	2020
Evaluation of Risk Factors of Peripheral Neuropathy in Type 2 Diabetes Mellitus Patients with Special Reference to Vitamin B12 Defi ciency. The Journal of the Association of Physicians of India, 2020, Volume: 68, Issue:1 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous System Diseases; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency	2020
Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman. Sultan Qaboos University medical journal, 2020, Volume: 20, Issue:1 Topics: Adult; Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Oman; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency	2020
Vitamin B12 and Folate Concentrations in Recent-onset Type 2 Diabetes and the Effect of Metformin Treatment. The Journal of clinical endocrinology and metabolism, 2020, 06-01, Volume: 105, Issue:6 Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Prognosis; Prospective Studies; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult	2020
Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus. Acta diabetologica, 2020, Volume: 57, Issue:9 Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Prevalence; Prospective Studies; Risk Assessment; Vitamin B 12; Vitamin B 12 Deficiency	2020
The role of Helicobacter pylori in vitamin-B Helicobacter, 2020, Volume: 25, Issue:5 Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	2020
Long-term metformin treatment and risk of peripheral neuropathy in older Veterans. Diabetes research and clinical practice, 2020, Volume: 170 Topics: Aged; Alcoholism; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Hypoglycemic Agents; Logistic Models; Male; Metformin; Middle Aged; Retrospective Studies; Risk Factors; Smoking; Time Factors; Veterans; Vitamin B 12; Vitamin B 12 Deficiency	2020
Oral manifestation of vitamin B12 associated with metformin and proton pump inhibitors: oral signs of drug related hypovitaminosis. Minerva dental and oral science, 2021, Volume: 70, Issue:2 Topics: Humans; Metformin; Pharmaceutical Preparations; Proton Pump Inhibitors; Vitamin B 12; Vitamin B 12 Deficiency	2021
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus. Scientific reports, 2021, 01-21, Volume: 11, Issue:1 Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Homocysteine; Humans; Male; Metformin; Methylmalonic Acid; Middle Aged; Peripheral Nervous System Diseases; Risk Factors; Vitamin B 12	2021
Serum Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus on Metformin Compared to those Never on Metformin: A Cross-sectional Study from Bangladesh. Mymensingh medical journal : MMJ, 2021, Volume: 30, Issue:4 Topics: Adult; Bangladesh; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Infant; Metformin; Vitamin B 12	2021
Does Metformin Treatment in Pediatric Population Cause Vitamin B12 Deficiency? Klinische Padiatrie, 2022, Volume: 234, Issue:4 Topics: Adolescent; Child; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Male; Metabolic Syndrome; Metformin; Methylmalonic Acid; Prospective Studies; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency	2022
Safety update: metformin and vitamin B Drug and therapeutics bulletin, 2022, Volume: 60, Issue:9 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins	2022
[Peripheral neuropathy caused by vitamin B Zhonghua nei ke za zhi, 2022, Sep-01, Volume: 61, Issue:9 Topics: Glycogen Storage Disease Type I; Humans; Metformin; Peripheral Nervous System Diseases; Vitamin B 12; Vitamins	2022
Vitamin B12, folic acid, vitamin D, iron, ferritin, magnesium, and HbA1c levels in patients with diabetes mellitus and dental prosthesis. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:19 Topics: Case-Control Studies; Dental Prosthesis; Diabetes Mellitus; Ferritins; Folic Acid; Glycated Hemoglobin; Humans; Iron; Magnesium; Metformin; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin D; Vitamins	2022
[Cross-Sectional Study on Adverse Effects of Metformin Hydrochloride on 130 Patients Type 2 Diabetic Admitted to Medical Center and Diabetes Home of Sidi Bel-Abbès]. Annales pharmaceutiques francaises, 2023, Volume: 81, Issue:4 Topics: Acidosis, Lactic; Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hypersensitivity; Hypoglycemia; Hypoglycemic Agents; Metformin; Middle Aged; Muscle Cramp; Nuns; Vitamin B 12; Vitamin B 12 Deficiency	2023
Influence of metformin intake on serum vitamin B12 levels in patients with type 2 diabetes mellitus. PloS one, 2022, Volume: 17, Issue:12 Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Vitamin B 12; Vitamin B 12 Deficiency	2022
The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA. Communications biology, 2023, 01-24, Volume: 6, Issue:1 Topics: Animals; Caenorhabditis elegans; Diabetes Mellitus, Type 2; Escherichia coli; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2023
Serum Concentrations and Dietary Intake of Vitamin B International journal of molecular sciences, 2023, Feb-20, Volume: 24, Issue:4 Topics: Adolescent; Case-Control Studies; Child; Eating; Female; Humans; Male; Metformin; Vitamin B 12; Vitamins	2023
The Effect of Metformin on Vitamin B12 Deficiency and Stroke. The Israel Medical Association journal : IMAJ, 2023, Volume: 25, Issue:2 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Ischemic Stroke; Metformin; Prospective Studies; Stroke; Vitamin B 12; Vitamin B 12 Deficiency	2023
Metformin treatment and risk of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus in Beijing, China. Frontiers in endocrinology, 2023, Volume: 14 Topics: Beijing; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Metformin; Middle Aged; Vitamin B 12	2023
Determinants of vitamin B12 deficiency in patients with type-2 diabetes mellitus - A primary-care retrospective cohort study. BMC primary care, 2023, 04-20, Volume: 24, Issue:1 Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Folic Acid; Humans; Hypoglycemic Agents; Metformin; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency	2023
MMW Fortschritte der Medizin, 2023, Volume: 165, Issue:9 Topics: Humans; Metformin; Vitamin B 12	2023
Does Metformin in Different Doses Cause Vitamin B12 Deficiency? A cross-Sectional Study. Cellular and molecular biology (Noisy-le-Grand, France), 2023, Feb-28, Volume: 69, Issue:2 Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2023
Association between Acid-Lowering Agents, Metformin, and Vitamin B12 among Boston-Area Puerto Ricans. The Journal of nutrition, 2023, Volume: 153, Issue:8 Topics: Adult; Diabetes Mellitus, Type 2; Histamine; Histamine H2 Antagonists; Humans; Hypoglycemic Agents; Metformin; Proton Pump Inhibitors; Vitamin B 12; Vitamin B 12 Deficiency	2023
The effects of daily dose and treatment duration of metformin on the prevalence of vitamin B12 deficiency and peripheral neuropathy in Chinese patients with type 2 diabetes mellitus: A multicenter cross-sectional study. Journal of diabetes, 2023, Volume: 15, Issue:9 Topics: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Duration of Therapy; East Asian People; Humans; Hypoglycemic Agents; Metformin; Peripheral Nervous System Diseases; Prevalence; Vitamin B 12; Vitamin B 12 Deficiency	2023
Bacteroides ovatus accelerates metformin-induced vitamin B12 deficiency in type 2 diabetes patients by accumulating cobalamin. NPJ biofilms and microbiomes, 2023, 07-24, Volume: 9, Issue:1 Topics: Animals; Diabetes Mellitus, Type 2; Homocysteine; Humans; Metformin; Mice; Vitamin B 12; Vitamin B 12 Deficiency	2023
Evaluation level of serum vitamin B12 in Iraqi patients with diabetes mellitus type 2, who used the metformin drug as a hypoglycemic agent. Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:2 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Iraq; Metformin; Vitamin B 12; Vitamin B 12 Deficiency	2023
The Consequences of Lowering Vitamin B12 With Chronic Metformin Therapy. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2023, Volume: 29, Issue:11 Topics: Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12	2023
Effect of a combination of gliptin and metformin on serum vitamin B12, folic acid, and ferritin levels. Revista da Associacao Medica Brasileira (1992), 2023, Volume: 69, Issue:11 Topics: Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Ferritins; Folic Acid; Humans; Hypoglycemic Agents; Metformin; Vitamin B 12	2023