Compounds > metformin

metformin and transforming growth factor beta

metformin has been researched along with transforming growth factor beta in 51 studies

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (3.92)29.6817
2010's30 (58.82)24.3611
2020's19 (37.25)2.80

Authors

AuthorsStudies
Choudhury, GG; Feliers, D; Foretz, M; Kasinath, BS; Lee, MJ; Mahimainathan, L; Mariappan, MM; Musi, N; Sataranatarajan, K; Viollet, B; Weinberg, JM1
Kanazawa, I; Sugimoto, T; Yamaguchi, T; Yamauchi, M; Yano, S1
Cufí, S; Joven, J; Martin-Castillo, B; Menendez, JA; Oliveras-Ferraros, C; Vazquez-Martin, A1
Ishibashi, Y; Matsui, T; Takeuchi, M; Yamagishi, S1
Chang, JW; Kim, JH; Kim, JS; Kim, SB; Lee, JH; Lee, SK; Park, JS1
Baines, DL; Baker, EH; Garnett, JP; Gill, S; Knight, GM; Lindsay, JA; Naik, S; Tregoning, JS1
Chung, RT; Fusco, DN; Goto, K; Jilg, N; Kato, N; Lin, W; Peng, LF; Schaefer, EA; Shao, RX; Zhang, L; Zhao, H1
Gao, Q; Shen, S; Wang, Y; Xia, Yj; Yi, L; Zhang, C; Zhang, X1
Han, B; Ma, Q; Qi, M; Shen, C; Wang, L; Xia, P; Yang, M; Zhang, J1
Chung, YM; Han, S; Kim, BH; Lee, H; Lee, HG; Park, CH; Shin, K; Ye, SK1
Chen, Z; Duan, Z; Fu, R; Gui, B; Jia, L; Li, M; Lu, J; Lv, Z; Shi, J; Tian, L; Yang, Y; Yao, G1
Choi, YK; Jang, SY; Jeon, JH; Jeong, WI; Jung, GS; Kang, YN; Kim, MK; Lee, IK; Park, KG; Park, SY; Shin, EC1
Chen, H; Han, R; He, Y; Huang, W; Li, K; Li, L; Lin, C; Lu, C; Sun, F; Wang, Y; Zhang, K1
Babykutty, S; Chen, I; Chin, SM; Deshpande, V; Fukumura, D; Hato, T; Incio, J; Jain, RK; Liu, H; Suboj, P; Vardam-Kaur, T1
Gan, X; Lu, L; Miao, N; Shen, Y; Xu, D; Xu, J; Xue, H; Zhang, W; Zhou, L1
Edgerton, SM; Fan, Z; Harrell, JC; Liu, B; Thor, AD; Wahdan-Alaswad, R1
Ebata, T; Ishiwata, T; Iwama, A; Iwasawa, S; Koide, S; Kurimoto, R; Sekine, I; Tada, Y; Takiguchi, Y; Tatsumi, K1
Araya, J; Fujita, Y; Hara, H; Hashimoto, M; Ito, S; Kadota, T; Kaneko, Y; Kobayashi, K; Kohrogi, H; Kojima, J; Kurita, Y; Kuwano, K; Minagawa, S; Morikawa, T; Nakayama, K; Numata, T; Odaka, M; Saito, N; Sato, N; Takasaka, N; Tsubouchi, K; Utsumi, H; Wakui, H; Yanagisawa, H; Yoshida, M1
Fushida, S; Harada, S; Hayashi, H; Kinoshita, J; Makino, I; Miyashita, T; Nakanuma, S; Nakayama, A; Ninomiya, I; Ohta, T; Okamoto, K; Oyama, K; Sakai, S; Tajima, H; Takamura, H; Tsukada, T1
Bajgelman, MC; Borin, TF; de Campos Zuccari, DA; de Carvalho Ferreira, L; Leonel, C; Moschetta, MG; Viloria-Petit, AM1
Ch'ang, HJ; Chang, TM; Chang, VH; Chen, SL; Peng, SL; Tsai, YC; Tsai, YL; Yu, WC1
Chen, N; Deng, X; Li, R; Li, Y; Luo, M; Luo, Y; Mu, L; Ren, M; Tan, X; Wan, Q; Wang, L; Wu, J1
Boehm, M; Hallenbeck, J; Hollander, MC; Ishii, H; Latour, LL; Lin, PC; Merchant, AS; Min, Y; Munasinghe, J; Ray-Choudhury, A; Xiao, Z; Yang, D; Yang, L1
Chen, X; Jiang, K; Shao, J; Shen, Z; Wu, P; Xu, A; Yang, X; Zheng, G1
Du, C; Liu, Y; Luo, F; Wang, Y; Zhang, N; Zhao, M1
Hu, L; Wang, Y; Wu, Z1
Byeon, HJ; Cho, J; Choi, WH; Han, SY; Kang, JW; Kim, CS; Kim, JM; Kim, JY; Lee, EJ; Lee, WJ; Lee, YS; Oh, SH; Yoo, BR; Yoo, H1
Admasu, TD; Barardo, D; Cazenave-Gassiot, A; Chaithanya Batchu, K; Gruber, J; Lam, VYM; Ng, LF; Tolwinski, NS; Wenk, MR; Xiao, L1
Shen, X; Xie, Y; Yan, S; Ye, J; Zheng, L1
Chenhong, L; Dan, L; Jianfei, C; Jianlong, G; Yan, S; Yong, C1
Culig, Z1
Jang, H; Kim, A; Kim, H; Kim, MJ; Kim, YH; Lee, SB; Lee, SJ; Myung, JK; Park, EH; Park, JH; Park, S; Shim, S1
Evans, R; Fissell, WH; Harris, R; Humes, HD; Love, H; Roy, S; Wilson, M; Zent, R1
Abdallah, HI; Ali, EMT; El-Sayed, SM1
Barathidasan, R; Malarvizhi, R; Mani, S; Sekar, V; Vasanthi, HR1
An, G; Jing, X; Lei, J; Li, W; Luo, M; Meng, D; Ning, Q; Shao, S; Zhang, L; Zhao, L; Zhao, X1
Ahn, HM; Jeon, HB; Lee, JH; Lee, WJ; Roh, H; Roh, TS; Yun, CO1
Chen, K; Hua, F; Jin, Z; Kc, R; Liu, J; Nicolas, YSM; Song, Z; Sun, J; Wang, H; Wu, T; Zhang, M1
Hua, Z; Wei, P1
Dong, X; Jin, X1
Liu, J; Shu, G; Xiao, J; Xiao, Q; Yin, G1
Baeri, A; Balaguer, T; Bellusci, S; Camuzard, O; Cegarra-Escolano, M; Diazzi, S; Fassy, J; Levraut, M; Mari, B; Ploumellec, MA; Rezzonico, R; Vassaux, G1
Allwood, BW; Chiyaka, TL; Kleyhans, L; Moodley, S; Naidoo, CC; Segal, LN; Singh, S; Theron, G1
Mandape, SN; Olokpa, E; Pratap, S; Stewart, MV1
Blanco-Acevedo, C; Castaño, JP; Doval-Rosa, C; Fuentes-Fayos, AC; G-García, ME; Gahete, MD; Jiménez-Vacas, JM; López, M; Luque, RM; Martín-Colom, J; Montero-Hidalgo, AJ; Ortega-Salas, RM; Peralbo-Santaella, E; Pérez-Gómez, JM; Sánchez-Sánchez, R; Solivera, J; Tena-Sempere, M; Toledano-Delgado, Á; Torres, E1
Bae, HB; Bom, JS; Choi, JI; Jeong, S; Kim, J; Yin, M1
Ali, HS; El-Adl, MA; El-Shafei, RA; Nomier, Y1
Chen, H; Chen, Q; Chu, L; Liu, Y; Ou, X; Yang, J; Zhou, Z; Zou, Q1
Dolcet, X; Egea, J; Encinas, M; Matias-Guiu, X; Navaridas, R; Nicholson-Sabaté, N; Perramon-Güell, A; Ruiz-Mitjana, A; Vidal-Sabanés, M; Yeramian, A1
Morshed, N; Reza, MS; Reza, R; Samdani, MN1
Alcalde-Estévez, E; Castillo, C; Castro, A; Costa, IG; Fernández, L; Herrero, JI; Jansen, J; Kramann, R; Lamas, S; Miguel, V; Nagai, J; Ranz, I; Reimer, KC; Rey-Serra, C; Rodríguez González-Moro, JM; Sancho, D; Sevilla, L; Sirera, B; Tituaña, J1

Reviews

3 review(s) available for metformin and transforming growth factor beta

ArticleYear
Epithelial mesenchymal transition and resistance in endocrine-related cancers.
    Biochimica et biophysica acta. Molecular cell research, 2019, Volume: 1866, Issue:9

    Topics: Benzopyrans; Breast Neoplasms; Cadherins; Cell Plasticity; Cytokines; Disease Progression; Epidermal Growth Factor; Epithelial-Mesenchymal Transition; Female; Humans; Inflammation; Male; MAP Kinase Kinase 5; Metformin; MicroRNAs; Prostatic Neoplasms; Proto-Oncogene Proteins c-fos; Receptor, ErbB-2; Signal Transduction; Transforming Growth Factor beta

2019
Immunologic and imaging signatures in post tuberculosis lung disease.
    Tuberculosis (Edinburgh, Scotland), 2022, Volume: 136

    Topics: Biomarkers; Collagen; Complex Mixtures; Cytokines; Doxycycline; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Diseases; Metformin; Mycobacterium tuberculosis; Peptide Hydrolases; Transforming Growth Factor beta; Tuberculosis

2022
The effects of metformin on anti-Müllerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis.
    Journal of ovarian research, 2023, Jun-28, Volume: 16, Issue:1

    Topics: Anti-Mullerian Hormone; Databases, Factual; Female; Humans; Metformin; Polycystic Ovary Syndrome; PubMed; Transforming Growth Factor beta

2023

Other Studies

48 other study(ies) available for metformin and transforming growth factor beta

ArticleYear
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose; Hypertrophy; Intracellular Signaling Peptides and Proteins; Kidney; Metformin; Multienzyme Complexes; Phosphoproteins; Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Transforming Growth Factor beta

2007
Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression.
    Biochemical and biophysical research communications, 2008, Oct-24, Volume: 375, Issue:3

    Topics: Adenylate Kinase; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcification, Physiologic; Cell Differentiation; Metformin; Mice; Nitric Oxide Synthase Type III; Osteoblasts; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta

2008
Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.
    Cell cycle (Georgetown, Tex.), 2010, Nov-15, Volume: 9, Issue:22

    Topics: Animals; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cellular Senescence; Dogs; Epithelial-Mesenchymal Transition; Female; Fibrosis; Humans; Hypoglycemic Agents; Metformin; Neoplastic Stem Cells; Signal Transduction; Transforming Growth Factor beta

2010
Metformin inhibits advanced glycation end products (AGEs)-induced renal tubular cell injury by suppressing reactive oxygen species generation via reducing receptor for AGEs (RAGE) expression.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2012, Volume: 44, Issue:12

    Topics: AMP-Activated Protein Kinases; Apoptosis; Cells, Cultured; Chemokine CCL2; Diabetic Nephropathies; DNA Fragmentation; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Intercellular Adhesion Molecule-1; Kidney Tubules, Proximal; Metformin; Molecular Targeted Therapy; Osmolar Concentration; Protein Kinase Inhibitors; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Transforming Growth Factor beta; Up-Regulation

2012
AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition.
    American journal of physiology. Renal physiology, 2013, Mar-15, Volume: 304, Issue:6

    Topics: Albumins; Aldosterone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Cell Line; Epithelial-Mesenchymal Transition; Glucose; Heme Oxygenase-1; Humans; Metformin; NADPH Oxidase 4; NADPH Oxidases; Nephrosclerosis; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Ribonucleosides; Thioredoxins; Transforming Growth Factor beta

2013
Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose.
    Thorax, 2013, Volume: 68, Issue:9

    Topics: Animals; Bacterial Load; Blood Glucose; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokine CXCL9; Epithelial Cells; Granulocyte-Macrophage Colony-Stimulating Factor; Hyperglycemia; Interleukin-1alpha; Interleukin-6; Metformin; Mice; Mice, Inbred C57BL; Permeability; Pseudomonas aeruginosa; Receptors, Leptin; Respiratory System; Staphylococcus aureus; Transforming Growth Factor beta

2013
The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling.
    Journal of hepatology, 2013, Volume: 59, Issue:5

    Topics: Biopsy; Cell Line; Gene Expression Regulation; Hepacivirus; Hepatitis C; Humans; Liver; Metformin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta; Virus Replication

2013
Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats.
    Human reproduction (Oxford, England), 2013, Volume: 28, Issue:11

    Topics: Animals; Dehydroepiandrosterone; Female; Fibrosis; Hypoglycemic Agents; Hypolipidemic Agents; Metformin; Ovarian Diseases; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Simvastatin; Transforming Growth Factor beta; Uterine Diseases

2013
Metformin inhibits epithelial-mesenchymal transition in prostate cancer cells: involvement of the tumor suppressor miR30a and its target gene SOX4.
    Biochemical and biophysical research communications, 2014, Sep-26, Volume: 452, Issue:3

    Topics: Antigens, CD; beta Catenin; Cadherins; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoglycemic Agents; Luciferases; Male; Metformin; MicroRNAs; Prostate; Prostatectomy; Prostatic Neoplasms; RNA, Messenger; Signal Transduction; SOXC Transcription Factors; Transforming Growth Factor beta

2014
Metformin enhances the anti-adipogenic effects of atorvastatin via modulation of STAT3 and TGF-β/Smad3 signaling.
    Biochemical and biophysical research communications, 2015, Jan-02, Volume: 456, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Atorvastatin; Cell Differentiation; Cell Survival; Cyclin D1; Heptanoic Acids; Homeostasis; Hypoglycemic Agents; Kruppel-Like Transcription Factors; Metformin; Mice; Pyrroles; Signal Transduction; Smad3 Protein; Smad7 Protein; STAT3 Transcription Factor; Transforming Growth Factor beta; Tumor Suppressor Protein p53

2015
Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts.
    Life sciences, 2015, Apr-15, Volume: 127

    Topics: Animals; Collagen Type I; Connective Tissue Growth Factor; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Fibroblasts; Hypoglycemic Agents; Kidney; Metformin; Mice; Mice, Inbred BALB C; Phosphorylation; Primary Cell Culture; RNA, Small Interfering; Smad3 Protein; Transforming Growth Factor beta

2015
Small heterodimer partner attenuates profibrogenic features of hepatitis C virus-infected cells.
    Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:10

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cell Line, Tumor; Gluconeogenesis; Hepacivirus; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Metformin; Receptors, Cytoplasmic and Nuclear; Ribonucleotides; Signal Transduction; Transforming Growth Factor beta

2015
Metformin attenuates gefitinib-induced exacerbation of pulmonary fibrosis by inhibition of TGF-β signaling pathway.
    Oncotarget, 2015, Dec-22, Volume: 6, Issue:41

    Topics: Animals; Antineoplastic Agents; Bleomycin; Blotting, Western; Epithelial-Mesenchymal Transition; Flow Cytometry; Gefitinib; Humans; Immunohistochemistry; Lung Diseases, Interstitial; Male; Metformin; Pulmonary Fibrosis; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta

2015
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Interleukin-1beta; Macrophages; Male; Metformin; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms; Pancreatic Stellate Cells; Prognosis; STAT3 Transcription Factor; Transforming Growth Factor beta

2015
Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts.
    International journal of molecular sciences, 2016, Jan-22, Volume: 17, Issue:2

    Topics: Angiotensin II; Animals; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Gene Expression Regulation; Kidney Diseases; MAP Kinase Signaling System; Metformin; Mice; Transforming Growth Factor beta; Ureteral Obstruction

2016
Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer.
    Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:8

    Topics: Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Claudins; Disease-Free Survival; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knock-In Techniques; Humans; Mesenchymal Stem Cells; Metformin; Neoplasm Invasiveness; Prognosis; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Triple Negative Breast Neoplasms; Up-Regulation

2016
Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.
    International journal of oncology, 2016, Volume: 48, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; B7-H1 Antigen; Cell Line, Tumor; Cell Survival; Cisplatin; Dimethyl Sulfoxide; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Fibroblast Growth Factor 2; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lung Neoplasms; Metformin; Mutation; Purines; Quinazolines; Transforming Growth Factor beta

2016
Metformin attenuates lung fibrosis development via NOX4 suppression.
    Respiratory research, 2016, 08-30, Volume: 17, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Bleomycin; Cell Differentiation; Cells, Cultured; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Idiopathic Pulmonary Fibrosis; Lung; Metformin; Mice, Inbred C57BL; Myofibroblasts; NADPH Oxidase 4; Phosphorylation; Reactive Oxygen Species; RNA Interference; Smad Proteins; Time Factors; Transfection; Transforming Growth Factor beta

2016
Metformin inhibits the radiation-induced invasive phenotype of esophageal squamous cell carcinoma.
    International journal of oncology, 2016, Volume: 49, Issue:5

    Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Adhesion; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Hypoglycemic Agents; Metformin; Neoplasm Invasiveness; Phenotype; Phosphorylation; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Tumor Cells, Cultured; X-Rays

2016
Inhibition of Epithelial-Mesenchymal Transition and Metastasis by Combined TGFbeta Knockdown and Metformin Treatment in a Canine Mammary Cancer Xenograft Model.
    Journal of mammary gland biology and neoplasia, 2017, Volume: 22, Issue:1

    Topics: Animals; Cadherins; Cell Line, Tumor; Cell Movement; Dogs; Epithelial-Mesenchymal Transition; Mammary Neoplasms, Animal; Metformin; Neoplasm Invasiveness; Transforming Growth Factor beta

2017
Krüpple-like factor 10 regulates radio-sensitivity of pancreatic cancer via UV radiation resistance-associated gene.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017, Volume: 122, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Line, Tumor; DNA Repair; Early Growth Response Transcription Factors; Humans; Kruppel-Like Transcription Factors; Metformin; Mice; Pancreatic Neoplasms; Radiation Tolerance; Transforming Growth Factor beta

2017
MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway.
    Scientific reports, 2017, 02-23, Volume: 7

    Topics: 3' Untranslated Regions; Angiogenesis Inhibitors; Cell Movement; Cell Proliferation; Computational Biology; Gene Expression Regulation; Genes, Reporter; Human Umbilical Vein Endothelial Cells; Humans; Luciferases; Metformin; MicroRNAs; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta

2017
Attenuation of Myeloid-Specific TGFβ Signaling Induces Inflammatory Cerebrovascular Disease and Stroke.
    Circulation research, 2017, Dec-08, Volume: 121, Issue:12

    Topics: Animals; Cell Line; Immunosuppressive Agents; Inflammation; Metformin; Methotrexate; Mice; Mice, Inbred C57BL; Myeloid Cells; NF-kappa B; Penetrance; Signal Transduction; Stroke; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2017
Synergistic Chemopreventive and Therapeutic Effects of Co-drug UA-Met: Implication in Tumor Metastasis.
    Journal of agricultural and food chemistry, 2017, Dec-20, Volume: 65, Issue:50

    Topics: Animals; Cadherins; Cell Line, Tumor; Drug Synergism; Female; Humans; Metformin; Mice; Neoplasm Metastasis; Neoplasms; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Triterpenes; Ursolic Acid; Vimentin; Xenograft Model Antitumor Assays

2017
Aspirin and metformin exhibit antitumor activity in murine breast cancer.
    Oncology reports, 2018, Volume: 39, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aspirin; Breast Neoplasms; Cell Proliferation; Female; Humans; Hypoglycemic Agents; Metformin; Mice; Mice, Inbred BALB C; Mice, Nude; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2018
The regulatory effects of metformin on the [SNAIL/miR-34]:[ZEB/miR-200] system in the epithelial-mesenchymal transition(EMT) for colorectal cancer(CRC).
    European journal of pharmacology, 2018, Sep-05, Volume: 834

    Topics: Cell Movement; Cell Proliferation; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; HCT116 Cells; Humans; Metformin; MicroRNAs; Neoplasm Invasiveness; Snail Family Transcription Factors; Transforming Growth Factor beta; Zinc Finger E-box-Binding Homeobox 1

2018
Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 48, Issue:3

    Topics: Animals; Cells, Cultured; Class Ia Phosphatidylinositol 3-Kinase; Down-Regulation; Fibroblasts; Fibrosis; Forkhead Box Protein O3; Metformin; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Oxidative Stress; Radiation Injuries, Experimental; Radiation, Ionizing; RNA Interference; RNA, Small Interfering; Skin; STAT3 Transcription Factor; Transforming Growth Factor beta; Tumor Suppressor Protein p53

2018
Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.
    Developmental cell, 2018, 10-08, Volume: 47, Issue:1

    Topics: Aging; Allantoin; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Drosophila melanogaster; Drug Synergism; Ficusin; Gene Expression Regulation; Gene Regulatory Networks; Insulin-Like Growth Factor I; Lipid Metabolism; Lipids; Longevity; Metformin; Rifampin; Signal Transduction; Sirolimus; Sterol Regulatory Element Binding Protein 1; Transcriptome; Transforming Growth Factor beta

2018
Metformin alleviates hyperglycemia-induced apoptosis and differentiation suppression in osteoblasts through inhibiting the TLR4 signaling pathway.
    Life sciences, 2019, Jan-01, Volume: 216

    Topics: Animals; Apoptosis; Bone Density; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Line; Diabetes Mellitus, Experimental; Down-Regulation; Hyperglycemia; Hypoglycemic Agents; Male; Metformin; Mice; NF-kappa B; Osteoblasts; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Toll-Like Receptor 4; Transforming Growth Factor beta; Up-Regulation

2019
[Efficacy and safety of metformin for Behcet's disease and its effect on Treg/Th17 balance: a single-blinded, before-after study].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019, 02-28, Volume: 39, Issue:2

    Topics: Behcet Syndrome; Controlled Before-After Studies; Forkhead Transcription Factors; Humans; Immunosuppressive Agents; Interleukin-17; Interleukins; Metformin; Neoplasm Recurrence, Local; Nuclear Receptor Subfamily 1, Group F, Member 3; Recurrence; RNA, Messenger; Single-Blind Method; T-Lymphocytes, Regulatory; Th17 Cells; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2019
Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer.
    Cancer science, 2019, Volume: 110, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemoradiotherapy; Colon; Colonic Neoplasms; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Fluorouracil; Humans; Male; Metformin; Mice; Mice, Nude; Neoplasm Recurrence, Local; Phenformin; Rectal Neoplasms; Signal Transduction; Smad Proteins; STAT3 Transcription Factor; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2019
Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate
    Tissue engineering. Part A, 2020, Volume: 26, Issue:19-20

    Topics: Cells, Cultured; Humans; Kidney Tubules; Metformin; Receptor, Transforming Growth Factor-beta Type I; Transforming Growth Factor beta

2020
Histomorphological, VEGF and TGF-β immunoexpression changes in the diabetic rats' ovary and the potential amelioration following treatment with metformin and insulin.
    Journal of molecular histology, 2020, Volume: 51, Issue:3

    Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Female; Hypoglycemic Agents; Immunohistochemistry; Insulin; Metformin; Ovary; Rats; Transforming Growth Factor beta; Up-Regulation; Vascular Endothelial Growth Factor A

2020
Positive interaction of mangiferin with selected oral hypoglycemic drugs: a therapeutic strategy to alleviate diabetic nephropathy in experimental rats.
    Molecular biology reports, 2020, Volume: 47, Issue:6

    Topics: Animals; Antioxidants; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination; Gliclazide; Hypoglycemic Agents; Kidney; Kidney Function Tests; Male; Metformin; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Xanthones

2020
Metformin suppresses HIF-1α expression in cancer-associated fibroblasts to prevent tumor-stromal cross talk in breast cancer.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:8

    Topics: Adenylate Kinase; Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Line, Tumor; Chemokine CXCL12; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-8; MCF-7 Cells; Metformin; Neoplasm Invasiveness; Prolyl Hydroxylases; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment; Up-Regulation

2020
Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids.
    Annals of plastic surgery, 2021, 04-01, Volume: 86, Issue:4

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta; Transforming Growth Factor beta1

2021
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
    Journal of cellular and molecular medicine, 2021, Volume: 25, Issue:7

    Topics: Animals; Failed Back Surgery Syndrome; Fibrosis; HMGB1 Protein; Humans; Male; Metformin; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Signal Transduction; Smad3 Protein; Toll-Like Receptor 4; Transforming Growth Factor beta

2021
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
    Annals of plastic surgery, 2022, 09-01, Volume: 89, Issue:3

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta; Transforming Growth Factor beta1

2022
Letter to the Editor: Comment on Jeon HB, et al. Metformin Inhibits Transforming Growth Factor β-Induced Fibrogenic Response of Human Dermal Fibroblasts and Suppresses Fibrosis in Keloid Spheroids ( Ann Plast Surg . 2021;86:406-411).
    Annals of plastic surgery, 2022, 09-01, Volume: 89, Issue:3

    Topics: Cells, Cultured; Fibroblasts; Fibrosis; Humans; Keloid; Metformin; Transforming Growth Factor beta; Transforming Growth Factor beta1

2022
Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction.
    Cell death & disease, 2022, 03-02, Volume: 13, Issue:3

    Topics: Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Metformin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Transforming Growth Factor beta

2022
A role for metformin in the treatment of Dupuytren disease?
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 150

    Topics: Cells, Cultured; Dupuytren Contracture; Fibroblasts; Fibrosis; Humans; Metformin; Neoplasm Recurrence, Local; Transforming Growth Factor beta

2022
Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells.
    BMC cancer, 2022, Sep-29, Volume: 22, Issue:1

    Topics: Androgens; Castration; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glucose; Humans; Insulins; Male; Metformin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; RNA, Messenger; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Wnt Signaling Pathway

2022
Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence.
    EBioMedicine, 2023, Volume: 90

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Mice; Proto-Oncogene Proteins c-akt; Retrospective Studies; Simvastatin; Transforming Growth Factor beta

2023
AMPK reduces macrophage endotoxin tolerance through inhibition of TGF-β1 production and its signaling pathway.
    International immunopharmacology, 2023, Volume: 118

    Topics: AMP-Activated Protein Kinases; Animals; Endotoxin Tolerance; Interleukin-6; Lipopolysaccharides; Macrophages; Metformin; Mice; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2023
Ameliorative effect of Arabic gum Acacia and mori extracts in streptozotocin-induced diabetic rats: implications of Cas-3 and TGF-β.
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:7

    Topics: Acacia; Animals; Antioxidants; Blood Glucose; Caspase 3; Diabetes Mellitus, Experimental; Gum Arabic; Hypoglycemic Agents; Metformin; Oxidative Stress; Plant Extracts; Rats; Streptozocin; Transforming Growth Factor beta

2023
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 168

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Diabetes Mellitus, Type 2; Endometrial Neoplasms; Female; Humans; Metformin; Mice; Transforming Growth Factor beta

2023
Pharmacophore mapping approach to find anti-cancer phytochemicals with metformin-like activities against transforming growth factor (TGF)-beta receptor I kinase: An in silico study.
    PloS one, 2023, Volume: 18, Issue:11

    Topics: Diabetes Mellitus, Type 2; Humans; Ligands; Metformin; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Pharmacophore; Transforming Growth Factor beta

2023
Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney.
    Redox biology, 2023, Volume: 68

    Topics: AMP-Activated Protein Kinases; Animals; COVID-19; Fatty Acids; Fibrosis; Humans; Inflammation; Kidney; Lung; Metformin; Respiratory Distress Syndrome; Transforming Growth Factor beta

2023